from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0067c/-

LFCtreatmentdescriptionclass of inhibitor

0.932

Amikacinug/mL Amikacintranslation

0.433

Cap5-10ug/mL Capreomycintranslation

0.439

Rox10-50 ug/mL Roxithromycintranslation

-0.560

SM2-5 ug/mL Streptomycintranslation

0.804

Tet5-10 ug/mL Tetracyclinetranslation

0.394

Rif0.2-5ug/mL Rifampicintranscription

0.287

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.275

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.128

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.531

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.405

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.508

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.203

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.381

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.975

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.135

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.586

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.941

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.144

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.837

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.287

KCN5-20 ug/mL Potassium cyaniderespiration

-0.611

NaN30.2-2 mM Sodium aziderespiration

0.203

Nigericin50 uM Nigericinrespiration

0.432

TRC10-150 ug/mL Triclosanrespiration

-0.679

TRZ10-25 ug/mL Thioridazinerespiration

-0.423

Valinomycin0.5-10 uM Valinomycinrespiration

0.089

ZnSO42 mM ZnSO4respiration

-0.286

menadione6-10 ug/mL Menadionerespiration

-0.033

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.034

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.351

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.731

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.210

NRP_1Non-replicating persistence stage 1dosRassociated

-0.821

Amp0.2mg/mL AmpicillincellWall

-0.339

Cephalexin20-100 ug/mL CephalexincellWall

0.126

Cerulenin0.32-5 ug/mL CerulenincellWall

0.864

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.494

EMB10-20 ug/mL EthambutolcellWall

0.541

Eta12-40 ug/mL EthionamidecellWall

-0.226

INH0.2-0.4 ug/mL IsoniazidcellWall

0.077

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.600

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.380

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.340

BZA0.12 mg/mL BenzamidearomaticAmides

0.199

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.326

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.087

H2O24 mM hydrogen peroxideDNAdamaging

-0.263

Levo10 ug/mL LevofloxacinDNAdamaging

0.294

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.438

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.240

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.043

UVUV-irradiationDNAdamaging

-0.500

ARP41-4 ug/mL Antitubercular compound ARP4?

-1.012

Antimycin12.5-50 ug/mL Antimycin A?

-0.627

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.127

PA_110-50 ug/mL Antitubercular compound PA-1?

0.930

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.019

PA8240.2-2 ug/mL PA-824?

0.143

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.482

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.591

Verapamil50 uM Verapamil?

-0.572

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.789

methoxatin10-20 ug/mL Methoxatin?