from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0062/celA1

LFCtreatmentdescriptionclass of inhibitor

-0.028

Amikacinug/mL Amikacintranslation

0.034

Cap5-10ug/mL Capreomycintranslation

1.062

Rox10-50 ug/mL Roxithromycintranslation

0.662

SM2-5 ug/mL Streptomycintranslation

1.760

Tet5-10 ug/mL Tetracyclinetranslation

-0.110

Rif0.2-5ug/mL Rifampicintranscription

0.209

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.176

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.720

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.274

CPZ10-50 ug/mL Chlorpromazinerespiration

1.053

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.334

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.315

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.170

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.540

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.000

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.028

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.464

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.088

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.720

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.088

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.630

Nigericin50 uM Nigericinrespiration

0.115

TRC10-150 ug/mL Triclosanrespiration

0.725

TRZ10-25 ug/mL Thioridazinerespiration

-0.458

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.850

menadione6-10 ug/mL Menadionerespiration

0.117

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.675

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.057

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.024

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.095

NRP_1Non-replicating persistence stage 1dosRassociated

0.006

Amp0.2mg/mL AmpicillincellWall

-0.553

Cephalexin20-100 ug/mL CephalexincellWall

0.332

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.811

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.086

EMB10-20 ug/mL EthambutolcellWall

-0.814

Eta12-40 ug/mL EthionamidecellWall

0.606

INH0.2-0.4 ug/mL IsoniazidcellWall

0.062

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.260

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.473

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.359

BZA0.12 mg/mL BenzamidearomaticAmides

0.560

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.078

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.343

H2O24 mM hydrogen peroxideDNAdamaging

-0.186

Levo10 ug/mL LevofloxacinDNAdamaging

0.024

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.305

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.666

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.138

UVUV-irradiationDNAdamaging

-0.534

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.787

Antimycin12.5-50 ug/mL Antimycin A?

-1.127

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.308

PA_110-50 ug/mL Antitubercular compound PA-1?

1.126

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.400

PA8240.2-2 ug/mL PA-824?

-0.747

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.941

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.616

Verapamil50 uM Verapamil?

-0.733

mercaptoethanol2 mM 2-Mercaptoethanol?

0.221

methoxatin10-20 ug/mL Methoxatin?