from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0055/rpsR1

LFCtreatmentdescriptionclass of inhibitor

2.652

Amikacinug/mL Amikacintranslation

2.342

Cap5-10ug/mL Capreomycintranslation

2.807

Rox10-50 ug/mL Roxithromycintranslation

1.079

SM2-5 ug/mL Streptomycintranslation

2.540

Tet5-10 ug/mL Tetracyclinetranslation

-1.138

Rif0.2-5ug/mL Rifampicintranscription

-0.119

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.445

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.290

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.633

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.729

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.344

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.411

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.664

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.109

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.331

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.566

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.989

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.410

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.013

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.980

KCN5-20 ug/mL Potassium cyaniderespiration

-0.855

NaN30.2-2 mM Sodium aziderespiration

1.211

Nigericin50 uM Nigericinrespiration

-0.062

TRC10-150 ug/mL Triclosanrespiration

-0.766

TRZ10-25 ug/mL Thioridazinerespiration

-0.318

Valinomycin0.5-10 uM Valinomycinrespiration

0.560

ZnSO42 mM ZnSO4respiration

-0.048

menadione6-10 ug/mL Menadionerespiration

-0.579

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.412

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.083

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.510

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.146

NRP_1Non-replicating persistence stage 1dosRassociated

0.317

Amp0.2mg/mL AmpicillincellWall

0.332

Cephalexin20-100 ug/mL CephalexincellWall

0.552

Cerulenin0.32-5 ug/mL CerulenincellWall

0.348

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.023

EMB10-20 ug/mL EthambutolcellWall

0.613

Eta12-40 ug/mL EthionamidecellWall

1.013

INH0.2-0.4 ug/mL IsoniazidcellWall

0.237

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.042

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.025

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.227

BZA0.12 mg/mL BenzamidearomaticAmides

-0.309

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.419

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.731

H2O24 mM hydrogen peroxideDNAdamaging

1.696

Levo10 ug/mL LevofloxacinDNAdamaging

1.039

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.173

Novobiocin10 ug/mL NovobiocinDNAdamaging

2.597

Oflox5-10 ug/mL OfloxacinDNAdamaging

1.261

UVUV-irradiationDNAdamaging

-0.228

ARP41-4 ug/mL Antitubercular compound ARP4?

0.217

Antimycin12.5-50 ug/mL Antimycin A?

0.218

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.059

PA_110-50 ug/mL Antitubercular compound PA-1?

0.121

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.170

PA8240.2-2 ug/mL PA-824?

-1.555

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.099

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.106

Verapamil50 uM Verapamil?

0.141

mercaptoethanol2 mM 2-Mercaptoethanol?

0.246

methoxatin10-20 ug/mL Methoxatin?