from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0049/-

LFCtreatmentdescriptionclass of inhibitor

-1.807

Amikacinug/mL Amikacintranslation

-1.715

Cap5-10ug/mL Capreomycintranslation

-2.641

Rox10-50 ug/mL Roxithromycintranslation

-0.424

SM2-5 ug/mL Streptomycintranslation

-2.499

Tet5-10 ug/mL Tetracyclinetranslation

-1.287

Rif0.2-5ug/mL Rifampicintranscription

-0.482

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.549

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.398

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.630

CPZ10-50 ug/mL Chlorpromazinerespiration

0.337

Clofazimine10-13 ug/mL Clofaziminerespiration

0.070

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.321

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.759

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.053

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.142

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.048

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.672

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.577

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.117

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.358

KCN5-20 ug/mL Potassium cyaniderespiration

0.129

NaN30.2-2 mM Sodium aziderespiration

1.047

Nigericin50 uM Nigericinrespiration

1.804

TRC10-150 ug/mL Triclosanrespiration

0.487

TRZ10-25 ug/mL Thioridazinerespiration

-2.555

Valinomycin0.5-10 uM Valinomycinrespiration

-0.759

ZnSO42 mM ZnSO4respiration

-0.169

menadione6-10 ug/mL Menadionerespiration

0.023

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.172

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.376

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.506

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.182

NRP_1Non-replicating persistence stage 1dosRassociated

0.064

Amp0.2mg/mL AmpicillincellWall

0.144

Cephalexin20-100 ug/mL CephalexincellWall

-0.238

Cerulenin0.32-5 ug/mL CerulenincellWall

0.175

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.397

EMB10-20 ug/mL EthambutolcellWall

0.783

Eta12-40 ug/mL EthionamidecellWall

0.980

INH0.2-0.4 ug/mL IsoniazidcellWall

0.057

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.253

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.330

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.102

BZA0.12 mg/mL BenzamidearomaticAmides

0.166

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.139

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.942

H2O24 mM hydrogen peroxideDNAdamaging

0.284

Levo10 ug/mL LevofloxacinDNAdamaging

-0.594

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

2.072

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.616

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.019

UVUV-irradiationDNAdamaging

1.287

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.144

Antimycin12.5-50 ug/mL Antimycin A?

-0.045

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.101

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.141

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.369

PA8240.2-2 ug/mL PA-824?

0.713

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.448

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.121

Verapamil50 uM Verapamil?

-0.129

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.560

methoxatin10-20 ug/mL Methoxatin?