from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0047c/-

LFCtreatmentdescriptionclass of inhibitor

-0.121

Amikacinug/mL Amikacintranslation

1.299

Cap5-10ug/mL Capreomycintranslation

3.748

Rox10-50 ug/mL Roxithromycintranslation

-0.474

SM2-5 ug/mL Streptomycintranslation

0.806

Tet5-10 ug/mL Tetracyclinetranslation

-0.668

Rif0.2-5ug/mL Rifampicintranscription

-0.396

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.616

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.949

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.140

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.079

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.802

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.234

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.809

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.713

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.582

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.416

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.268

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.815

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.584

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.034

KCN5-20 ug/mL Potassium cyaniderespiration

-0.890

NaN30.2-2 mM Sodium aziderespiration

-0.070

Nigericin50 uM Nigericinrespiration

-0.875

TRC10-150 ug/mL Triclosanrespiration

-0.490

TRZ10-25 ug/mL Thioridazinerespiration

1.691

Valinomycin0.5-10 uM Valinomycinrespiration

-0.175

ZnSO42 mM ZnSO4respiration

-0.486

menadione6-10 ug/mL Menadionerespiration

0.089

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.522

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.675

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.384

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.610

NRP_1Non-replicating persistence stage 1dosRassociated

-0.042

Amp0.2mg/mL AmpicillincellWall

-0.377

Cephalexin20-100 ug/mL CephalexincellWall

-0.652

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.201

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.370

EMB10-20 ug/mL EthambutolcellWall

-0.339

Eta12-40 ug/mL EthionamidecellWall

0.044

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.379

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.269

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.388

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.549

BZA0.12 mg/mL BenzamidearomaticAmides

0.202

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.105

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.158

H2O24 mM hydrogen peroxideDNAdamaging

-0.415

Levo10 ug/mL LevofloxacinDNAdamaging

-0.351

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.207

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.402

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.026

UVUV-irradiationDNAdamaging

-1.113

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.393

Antimycin12.5-50 ug/mL Antimycin A?

-0.426

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.147

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.006

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.014

PA8240.2-2 ug/mL PA-824?

1.439

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.061

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.523

Verapamil50 uM Verapamil?

-0.225

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.130

methoxatin10-20 ug/mL Methoxatin?