from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0026/-

LFCtreatmentdescriptionclass of inhibitor

0.401

Amikacinug/mL Amikacintranslation

1.338

Cap5-10ug/mL Capreomycintranslation

2.331

Rox10-50 ug/mL Roxithromycintranslation

0.745

SM2-5 ug/mL Streptomycintranslation

1.293

Tet5-10 ug/mL Tetracyclinetranslation

0.122

Rif0.2-5ug/mL Rifampicintranscription

-0.386

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.893

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.893

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.851

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.823

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.139

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.681

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.731

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.518

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.594

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.767

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.403

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.459

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.823

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.231

KCN5-20 ug/mL Potassium cyaniderespiration

-1.341

NaN30.2-2 mM Sodium aziderespiration

1.723

Nigericin50 uM Nigericinrespiration

0.059

TRC10-150 ug/mL Triclosanrespiration

-0.836

TRZ10-25 ug/mL Thioridazinerespiration

1.070

Valinomycin0.5-10 uM Valinomycinrespiration

-1.262

ZnSO42 mM ZnSO4respiration

-0.201

menadione6-10 ug/mL Menadionerespiration

-0.813

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.374

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.665

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.530

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.959

NRP_1Non-replicating persistence stage 1dosRassociated

-0.159

Amp0.2mg/mL AmpicillincellWall

-0.082

Cephalexin20-100 ug/mL CephalexincellWall

0.604

Cerulenin0.32-5 ug/mL CerulenincellWall

0.050

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.051

EMB10-20 ug/mL EthambutolcellWall

0.221

Eta12-40 ug/mL EthionamidecellWall

-0.235

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.405

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.126

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.313

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.155

BZA0.12 mg/mL BenzamidearomaticAmides

0.329

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.342

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.054

H2O24 mM hydrogen peroxideDNAdamaging

0.094

Levo10 ug/mL LevofloxacinDNAdamaging

0.494

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.473

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.130

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.388

UVUV-irradiationDNAdamaging

-1.323

ARP41-4 ug/mL Antitubercular compound ARP4?

0.164

Antimycin12.5-50 ug/mL Antimycin A?

0.188

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.833

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.081

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.020

PA8240.2-2 ug/mL PA-824?

-0.797

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.482

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.283

Verapamil50 uM Verapamil?

-0.044

mercaptoethanol2 mM 2-Mercaptoethanol?

0.846

methoxatin10-20 ug/mL Methoxatin?