from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0020c/fhaA

LFCtreatmentdescriptionclass of inhibitor

0.931

Amikacinug/mL Amikacintranslation

1.953

Cap5-10ug/mL Capreomycintranslation

1.017

Rox10-50 ug/mL Roxithromycintranslation

0.481

SM2-5 ug/mL Streptomycintranslation

2.347

Tet5-10 ug/mL Tetracyclinetranslation

-1.260

Rif0.2-5ug/mL Rifampicintranscription

-1.276

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.413

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.123

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.206

CPZ10-50 ug/mL Chlorpromazinerespiration

0.006

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.434

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.129

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.069

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.744

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.573

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.371

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.057

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.156

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.499

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.842

KCN5-20 ug/mL Potassium cyaniderespiration

0.021

NaN30.2-2 mM Sodium aziderespiration

2.253

Nigericin50 uM Nigericinrespiration

0.356

TRC10-150 ug/mL Triclosanrespiration

0.154

TRZ10-25 ug/mL Thioridazinerespiration

0.542

Valinomycin0.5-10 uM Valinomycinrespiration

-0.032

ZnSO42 mM ZnSO4respiration

-0.447

menadione6-10 ug/mL Menadionerespiration

-0.546

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.467

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.574

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.274

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.701

NRP_1Non-replicating persistence stage 1dosRassociated

0.195

Amp0.2mg/mL AmpicillincellWall

-0.302

Cephalexin20-100 ug/mL CephalexincellWall

1.284

Cerulenin0.32-5 ug/mL CerulenincellWall

0.193

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.476

EMB10-20 ug/mL EthambutolcellWall

0.896

Eta12-40 ug/mL EthionamidecellWall

1.163

INH0.2-0.4 ug/mL IsoniazidcellWall

0.595

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.798

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.233

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.305

BZA0.12 mg/mL BenzamidearomaticAmides

0.453

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.133

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.560

H2O24 mM hydrogen peroxideDNAdamaging

-0.239

Levo10 ug/mL LevofloxacinDNAdamaging

0.443

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.268

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.260

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.168

UVUV-irradiationDNAdamaging

-1.825

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.324

Antimycin12.5-50 ug/mL Antimycin A?

0.045

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.321

PA_110-50 ug/mL Antitubercular compound PA-1?

0.330

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.091

PA8240.2-2 ug/mL PA-824?

1.237

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.293

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.642

Verapamil50 uM Verapamil?

-0.605

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.420

methoxatin10-20 ug/mL Methoxatin?