from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0019c/fhaB

LFCtreatmentdescriptionclass of inhibitor

0.510

Amikacinug/mL Amikacintranslation

-0.198

Cap5-10ug/mL Capreomycintranslation

0.254

Rox10-50 ug/mL Roxithromycintranslation

0.091

SM2-5 ug/mL Streptomycintranslation

0.440

Tet5-10 ug/mL Tetracyclinetranslation

0.383

Rif0.2-5ug/mL Rifampicintranscription

-0.124

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.194

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.613

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.450

CPZ10-50 ug/mL Chlorpromazinerespiration

1.231

Clofazimine10-13 ug/mL Clofaziminerespiration

0.103

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.194

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.366

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.662

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.691

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.393

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.942

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.455

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.260

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.100

KCN5-20 ug/mL Potassium cyaniderespiration

-1.057

NaN30.2-2 mM Sodium aziderespiration

0.053

Nigericin50 uM Nigericinrespiration

0.504

TRC10-150 ug/mL Triclosanrespiration

1.523

TRZ10-25 ug/mL Thioridazinerespiration

0.243

Valinomycin0.5-10 uM Valinomycinrespiration

-0.180

ZnSO42 mM ZnSO4respiration

-0.410

menadione6-10 ug/mL Menadionerespiration

-0.561

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.742

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.672

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.302

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.933

NRP_1Non-replicating persistence stage 1dosRassociated

-0.748

Amp0.2mg/mL AmpicillincellWall

0.188

Cephalexin20-100 ug/mL CephalexincellWall

-0.128

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.700

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.604

EMB10-20 ug/mL EthambutolcellWall

0.112

Eta12-40 ug/mL EthionamidecellWall

0.354

INH0.2-0.4 ug/mL IsoniazidcellWall

0.042

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.794

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.914

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.230

BZA0.12 mg/mL BenzamidearomaticAmides

-0.095

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.019

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.236

H2O24 mM hydrogen peroxideDNAdamaging

-0.429

Levo10 ug/mL LevofloxacinDNAdamaging

-0.185

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.016

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.107

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.338

UVUV-irradiationDNAdamaging

1.264

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.528

Antimycin12.5-50 ug/mL Antimycin A?

0.056

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.020

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.465

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.058

PA8240.2-2 ug/mL PA-824?

0.503

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.556

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.315

Verapamil50 uM Verapamil?

-0.573

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.177

methoxatin10-20 ug/mL Methoxatin?