from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0018c/pstP

LFCtreatmentdescriptionclass of inhibitor

-2.773

Amikacinug/mL Amikacintranslation

-3.162

Cap5-10ug/mL Capreomycintranslation

-3.362

Rox10-50 ug/mL Roxithromycintranslation

-0.249

SM2-5 ug/mL Streptomycintranslation

-2.768

Tet5-10 ug/mL Tetracyclinetranslation

-0.118

Rif0.2-5ug/mL Rifampicintranscription

-0.148

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.176

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.889

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.457

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.003

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.440

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.557

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.035

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.660

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.539

Nigericin50 uM Nigericinrespiration

-0.682

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.759

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

1.378

menadione6-10 ug/mL Menadionerespiration

0.044

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.040

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.006

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.807

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.014

NRP_1Non-replicating persistence stage 1dosRassociated

0.273

Amp0.2mg/mL AmpicillincellWall

0.942

Cephalexin20-100 ug/mL CephalexincellWall

0.125

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.225

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.039

EMB10-20 ug/mL EthambutolcellWall

0.199

Eta12-40 ug/mL EthionamidecellWall

0.468

INH0.2-0.4 ug/mL IsoniazidcellWall

0.156

TLM0.1-0.2 mg/mL ThiolactomycincellWall

2.020

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.168

BZA0.12 mg/mL BenzamidearomaticAmides

0.028

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.199

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.038

H2O24 mM hydrogen peroxideDNAdamaging

-0.339

Levo10 ug/mL LevofloxacinDNAdamaging

0.363

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.520

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.183

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.015

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.011

Antimycin12.5-50 ug/mL Antimycin A?

-0.044

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.738

PA_110-50 ug/mL Antitubercular compound PA-1?

0.553

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.104

PA8240.2-2 ug/mL PA-824?

0.580

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.496

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.355

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

3.244

methoxatin10-20 ug/mL Methoxatin?