from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv0002/dnaN

LFCtreatmentdescriptionclass of inhibitor

0.386

Amikacinug/mL Amikacintranslation

1.083

Cap5-10ug/mL Capreomycintranslation

2.592

Rox10-50 ug/mL Roxithromycintranslation

0.400

SM2-5 ug/mL Streptomycintranslation

1.055

Tet5-10 ug/mL Tetracyclinetranslation

0.492

Rif0.2-5ug/mL Rifampicintranscription

0.639

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.512

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.978

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.425

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.800

Clofazimine10-13 ug/mL Clofaziminerespiration

0.215

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.314

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.508

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.144

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.315

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.875

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.354

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.944

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.274

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.537

KCN5-20 ug/mL Potassium cyaniderespiration

-0.629

NaN30.2-2 mM Sodium aziderespiration

0.268

Nigericin50 uM Nigericinrespiration

0.231

TRC10-150 ug/mL Triclosanrespiration

-0.587

TRZ10-25 ug/mL Thioridazinerespiration

0.187

Valinomycin0.5-10 uM Valinomycinrespiration

0.294

ZnSO42 mM ZnSO4respiration

-1.277

menadione6-10 ug/mL Menadionerespiration

-0.618

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.448

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.103

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.004

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.253

NRP_1Non-replicating persistence stage 1dosRassociated

0.046

Amp0.2mg/mL AmpicillincellWall

0.115

Cephalexin20-100 ug/mL CephalexincellWall

0.643

Cerulenin0.32-5 ug/mL CerulenincellWall

0.250

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.544

EMB10-20 ug/mL EthambutolcellWall

0.228

Eta12-40 ug/mL EthionamidecellWall

0.741

INH0.2-0.4 ug/mL IsoniazidcellWall

0.212

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.523

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.335

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.366

BZA0.12 mg/mL BenzamidearomaticAmides

0.603

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.548

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.550

H2O24 mM hydrogen peroxideDNAdamaging

0.353

Levo10 ug/mL LevofloxacinDNAdamaging

0.312

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.267

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.294

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.643

UVUV-irradiationDNAdamaging

-1.555

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.067

Antimycin12.5-50 ug/mL Antimycin A?

-0.288

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.103

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.369

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.318

PA8240.2-2 ug/mL PA-824?

-0.805

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.037

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.112

Verapamil50 uM Verapamil?

-0.370

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.529

methoxatin10-20 ug/mL Methoxatin?