Rv3843c (-)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: hypothetical protein
- REFSEQ: transmembrane protein
- PATRIC: PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
- TUBERCULIST: Probable conserved transmembrane protein
- NCBI: Probable conserved transmembrane protein
- updated information (H37Rv4):
  - gene name: -
  - function:
  - reference:
Type: Not Target
Start: 4315568
End: 4316596
Operon:

Trans-membrane region:
Role: II.C.5 - Other membrane proteins
GO terms:
- GO:0016021 - integral component of membrane (Uniprot)
- GO:0016020 - membrane (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB
Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
Links to additional information on Rv3843c:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = -0.248 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

VIQVCSQCGTGWNVRERQRVWCPRCRGMLLAPLADMPAEARWRTPARPQVPTASDTRRTPPRLPPGFRWIAVRPGAAPPPRHGPRLRGPTPRYAGIPRWG
LTDHVDQAPVPASAKAGPSPAAVRTTLLVSLLVFSIAVVVFVVRYVLLVINRNTLLNSVVASASVWLGVLVSLAAIAAAGTTIVLLVRWLVARRAAAFMH
QGLPERRSARELWAGCLLPMVNLLWAPLYVIELALVEDRYTRLRRPIVVWWIVWIVSNAISMFAFATSWVTDAQGIANNTTMMVLAYLCAAAAVAAAARV
FEGFEQKPVERPAHRWVVVNTDGRSAPASSVAVELDGQEPAA

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Essential	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.999900; 17 non-insertions in a row out of 17 sites
Non-Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.001700; 6 non-insertions in a row out of 17 sites
Non-Essential	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.002600; 6 non-insertions in a row out of 17 sites
Non-Essential	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.001100; 6 non-insertions in a row out of 18 sites
Essential	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.999750; 12 non-insertions in a row out of 18 sites
Non-Essential	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Non-Essential	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: 0.94
Essential-Domain	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

RNA processing and modification

Energy production and conversion

Chromatin structure and dynamics

Amino acid transport and metabolism

Cell cycle control, cell division, chromosome partitioning

Carbohydrate transport and metabolism

Nucleotide transport and metabolism

Lipid transport and metabolism

Coenzyme transport and metabolism

Transcription

Translation, ribosomal structure and biogenesis

Cell wall/membrane/envelope biogenesis

Replication, recombination and repair

Posttranslational modification, protein turnover, chaperones

Cell motility

Secondary metabolites biosynthesis, transport and catabolism

Inorganic ion transport and metabolism

Function unknown

General function prediction only

Intracellular trafficking, secretion, and vesicular transport

Signal transduction mechanisms

Extracellular structures

Defense mechanisms

Nuclear structure

Cytoskeleton

BioCyc Co-regulated genes based on gene expression profiling (Systems Biology, Inferelator Network)

Differentially expressed as result of RNASeq in glycerol environment (Only top 20 genes shown sorted by log fold change with p_adj 0.05).

Conditionally essential as result of TNSeq (Only top 20 genes shown sorted by log fold change with p_adj 0.05).

BioCyc Transcription factor binding based on ChIP-Seq (Systems Biology)

Binds To:
- No bindings to other targets were found.
Bound By:
- No bindings from other targets were found.

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv0135c (-) (Direct binding)
- Rv0302 (-) (Direct binding)
- Rv2011c (-) (Direct binding)

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Not upregulated by other genes.
Downregulates:
- Does not downregulate other genes.
Downregulated by:
- Not downregulated by other genes.

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv3843c (-)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	Transcription Rv3676	ashwinigbhat	IEP		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	ashwinigbhat	IPI	16267303	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	ashwinigbhat	IPI		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	ashwinigbhat	IPI		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	ashwinigbhat	IPI	15049808	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	ashwinigbhat	IPI		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	ashwinigbhat	IPI		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	ashwinigbhat	IPI		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	ashwinigbhat	IPI	15049808	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	ashwinigbhat	IPI		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	ashwinigbhat	IPI		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	ashwinigbhat	IEP	16267303	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	ashwinigbhat	IEP		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	ashwinigbhat	IEP		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	ashwinigbhat	IEP	15049808	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	ashwinigbhat	IEP		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	ashwinigbhat	IEP	16267303	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	ashwinigbhat	IEP		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	ashwinigbhat	IEP		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	ashwinigbhat	IEP	15049808	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	ashwinigbhat	IEP		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	ashwinigbhat	IEP		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	ashwinigbhat	IPI	16267303	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	ashwinigbhat	IPI		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	priti.priety	IEP	15049808	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	priti.priety	IEP		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	priti.priety	IEP		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	priti.priety	IPI	16267303	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	priti.priety	IPI		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	priti.priety	IPI		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	priti.priety	IPI	15049808	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	priti.priety	IPI		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	priti.priety	IPI		Affinity purification (Physical interaction) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv2069	priti.priety	IPI		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	priti.priety	IPI		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	priti.priety	IPI	15049808	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	priti.priety	IPI		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	priti.priety	IPI		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	priti.priety	IEP	16267303	Affinity purification (Physical interaction)
Interaction	Transcription Rv2069	priti.priety	IEP		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	priti.priety	IEP		Affinity purification (Physical interaction) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	priti.priety	IEP	16267303	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	priti.priety	IEP		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Interaction	Transcription Rv3676	priti.priety	IEP		Co-expression (Functional linkage) G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005
Citation	Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004	priti.priety	IEP	15049808	Co-expression (Functional linkage)
Interaction	Transcription Rv2069	priti.priety	IEP		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Interaction	Transcription Rv3676	priti.priety	IEP		Co-expression (Functional linkage) R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004
Citation	Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005	priti.priety	IPI	16267303	Co-expression (Functional linkage)
Interaction	RegulatedBy Rv3676	yamir.moreno	TAS		Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balzsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008

Property

Value

Creator

Evidence

PMID

Comment

Interaction

Transcription Rv3676

ashwinigbhat

IEP

Affinity purification (Physical interaction)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

ashwinigbhat

IPI

16267303

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

ashwinigbhat

IPI

Affinity purification (Physical interaction)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Interaction

Transcription Rv3676

ashwinigbhat

IPI

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

ashwinigbhat

IPI

15049808

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

ashwinigbhat

IPI

Interaction

Transcription Rv3676

ashwinigbhat

IPI

Interaction

Transcription Rv3676

ashwinigbhat

IPI

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

ashwinigbhat

IPI

15049808

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

ashwinigbhat

IPI

Co-expression (Functional linkage)
R. Sun, PJ. Converse et al. Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. Mol. Microbiol. 2004

Interaction

Transcription Rv3676

ashwinigbhat

IPI

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

ashwinigbhat

IEP

16267303

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

ashwinigbhat

IEP

Interaction

Transcription Rv3676

ashwinigbhat

IEP

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

ashwinigbhat

IEP

15049808

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

ashwinigbhat

IEP

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

ashwinigbhat

IEP

16267303

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

ashwinigbhat

IEP

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Interaction

Transcription Rv3676

ashwinigbhat

IEP

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

ashwinigbhat

IEP

15049808

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

ashwinigbhat

IEP

Interaction

Transcription Rv3676

ashwinigbhat

IEP

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

ashwinigbhat

IPI

16267303

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

ashwinigbhat

IPI

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

priti.priety

IEP

15049808

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

priti.priety

IEP

Interaction

Transcription Rv3676

priti.priety

IEP

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

priti.priety

IPI

16267303

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

priti.priety

IPI

Interaction

Transcription Rv3676

priti.priety

IPI

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

priti.priety

IPI

15049808

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

priti.priety

IPI

Interaction

Transcription Rv3676

priti.priety

IPI

Interaction

Transcription Rv2069

priti.priety

IPI

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Interaction

Transcription Rv3676

priti.priety

IPI

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

priti.priety

IPI

15049808

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

priti.priety

IPI

Interaction

Transcription Rv3676

priti.priety

IPI

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

priti.priety

IEP

16267303

Affinity purification (Physical interaction)

Interaction

Transcription Rv2069

priti.priety

IEP

Interaction

Transcription Rv3676

priti.priety

IEP

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

priti.priety

IEP

16267303

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

priti.priety

IEP

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Interaction

Transcription Rv3676

priti.priety

IEP

Co-expression (Functional linkage)
G. Bai, LA. McCue et al. Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 2005

Citation

Mycobacterium tuberculosis ECF sigma factor sigC is required for lethality in mice and for the conditional expression of a defined gene set. R. Sun, PJ. Converse et al. Mol. Microbiol. 2004

priti.priety

IEP

15049808

Co-expression (Functional linkage)

Interaction

Transcription Rv2069

priti.priety

IEP

Interaction

Transcription Rv3676

priti.priety

IEP

Citation

Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. G. Bai, LA. McCue et al. J. Bacteriol. 2005

priti.priety

IPI

16267303

Co-expression (Functional linkage)

Interaction

RegulatedBy Rv3676

yamir.moreno

TAS

Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support.
G. Balzsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008

Comments