TB Genome Annotation Portal

Rv3462c (infA)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: translation initiation factor IF-1
  • REFSEQ: translation initiation factor IF-1
  • PATRIC: Translation initiation factor 1
  • TUBERCULIST: Probable translation initiation factor if-1 InfA
  • NCBI: Probable translation initiation factor if-1 InfA
  • updated information (H37Rv4):
    • gene name: infA
    • function:
    • reference:
• Type: Not Target
• Start: 3880432
• End: 3880653
• Operon:


• Trans-membrane region:
  
• Role: II.A.6 - Protein translation and modification
• GO terms:
  • GO:0043022 - ribosome binding (Uniprot)
  • GO:0040007 - growth (Uniprot)
  • GO:0019843 - rRNA binding (Uniprot)
  • GO:0006413 - translational initiation (Uniprot)
  • GO:0006412 - translation (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005829 - cytosol (Uniprot)
  • GO:0005737 - cytoplasm (Uniprot)
  • GO:0005618 - cell wall (Uniprot)
  • GO:0003743 - translation initiation factor activity (Uniprot)
  • GO:0003723 - RNA binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure: 3i4o
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  3I4O	100%	Mycobacterium tuberculosis	Crystal Structure of Translation Initiation Factor 1 from Mycobacterium tuberculosis
  2N3S	70%	Burkholderia thailandensis E264	NMR Assignments and structure of Translation initiation factor IF-1 from Burkholderia thailandensis E264.
  1AH9	70%	Escherichia coli	THE STRUCTURE OF THE TRANSLATIONAL INITIATION FACTOR IF1 FROM ESCHERICHIA COLI, NMR, 19 STRUCTURES
  2N8N	69%	Staphylococcus aureus subsp. aureus Mu50	Solution structure of translation initiation factor
  2N78	69%	Pseudomonas aeruginosa	NMR structure of IF1 from Pseudomonas aeruginosa
  4QL5	68%	Streptococcus pneumoniae	Crystal structure of translation initiation factor IF-1 from Streptococcus pneumoniae TIGR4
  6C00	67%	Peptoclostridium difficile	Solution structure of translation initiation factor 1 from Clostridium difficile
  5ME1	66%	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)	Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112
  5ME0	66%	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)	Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112
  5LMV	66%	Thermus thermophilus HB8	Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III)

• Links to additional information on infA:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -13.39 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK

Additional Information