Rv3287c (rsbW)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: hypothetical protein
- REFSEQ: anti-sigma factor rsbW (sigma negative effector)
- PATRIC: Serine-protein kinase RsbW (EC 2.7.11.1)
- TUBERCULIST: Anti-sigma factor RsbW (sigma negative effector)
- NCBI: Anti-sigma factor RsbW (sigma negative effector)
- updated information (H37Rv4):
  - gene name: rsbW
  - function:
  - reference:
Type: Not Target
Start: 3668951
End: 3669388
Operon:

Trans-membrane region:
Role: II.A.7 - RNA synthesis, RNA modification and DNA transcription
GO terms:
- GO:0045892 - negative regulation of transcription, DNA-templated (Uniprot)
- GO:0016989 - sigma factor antagonist activity (Uniprot)
- GO:0016787 - hydrolase activity (Uniprot)
- GO:0006355 - regulation of transcription, DNA-templated (Uniprot)
- GO:0006351 - transcription, DNA-templated (Uniprot)
- GO:0005524 - ATP binding (Uniprot)
- GO:0005515 - protein binding (Uniprot)
- GO:0000166 - nucleotide binding (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB
Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
Links to additional information on rsbW:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = 0.177 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

MADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFEDLDFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVA
PGSFSWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Non-Essential	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 3 sites
Non-Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 3 sites
Non-Essential	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 0 non-insertions in a row out of 3 sites
Non-Essential	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 3 sites
Non-Essential	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.000000; 1 non-insertions in a row out of 3 sites
Non-Essential	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Non-Essential	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: 2.59
Growth-Advantage	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv3286c (sigF)

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv3286c (sigF) (Direct binding)

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Rv3286c (sigF)
Downregulates:
- Does not downregulate other genes.
Downregulated by:
- Not downregulated by other genes.

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv3287c (rsbW)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	Regulatory Rv3687c	akankshajain.21	IPI		Yeast two-hybrid (Physical interaction) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Structural Analysis S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Structural Analysis S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Structural Analysis S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Structural Analysis P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Structural Analysis P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Citation	Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. J. DeMaio, Y. Zhang et al. Tuber. Lung Dis. 1997	vijayachitra	IDA	9666957	Structural Analysis
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Structural Analysis J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Structural Analysis J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Structural Analysis J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Structural Analysis J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Citation	The sigma factors of Mycobacterium tuberculosis. S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli FEMS Microbiol. Rev. 2006	vijayachitra	IDA	17064287	Structural Analysis
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Structural Analysis S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Citation	Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. BK. Parida, T. Douglas et al. Tuberculosis (Edinburgh, Scotland) null	vijayachitra	IDA	16263329	Structural Analysis
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Structural Analysis BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Structural Analysis BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Structural Analysis BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Structural Analysis BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Citation	Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. P. Sachdeva, A. Narayan et al. FEBS J. 2008	vijayachitra	IDA	19016841	Structural Analysis
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Structural Analysis P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Structural Analysis P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Spectrophotometric S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Spectrophotometric S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Spectrophotometric S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Citation	Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Mol. Microbiol. 2002	vijayachitra	IDA	12354223	Structural Analysis
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Structural Analysis authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Structural Analysis authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Structural Analysis authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Structural Analysis authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Spectrophotometric P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Citation	Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. J. DeMaio, Y. Zhang et al. Tuber. Lung Dis. 1997	vijayachitra	IDA	9666957	Spectrophotometric
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Spectrophotometric J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Spectrophotometric J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Spectrophotometric J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Spectrophotometric J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997
Citation	The sigma factors of Mycobacterium tuberculosis. S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli FEMS Microbiol. Rev. 2006	vijayachitra	IDA	17064287	Spectrophotometric
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Spectrophotometric S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006
Citation	Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. BK. Parida, T. Douglas et al. Tuberculosis (Edinburgh, Scotland) null	vijayachitra	IDA	16263329	Spectrophotometric
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Spectrophotometric BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Spectrophotometric BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Spectrophotometric BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Spectrophotometric BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Citation	Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. P. Sachdeva, A. Narayan et al. FEBS J. 2008	vijayachitra	IDA	19016841	Spectrophotometric
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Spectrophotometric P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Spectrophotometric P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Spectrophotometric P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	Regulatory Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Citation	Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Mol. Microbiol. 2002	vijayachitra	IDA	12354223	Spectrophotometric
Interaction	Inhibits Rv3286c	vijayachitra	IDA		Spectrophotometric authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	Inhibits Rv1365c	vijayachitra	IDA		Spectrophotometric authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	InhibitedBy Rv3286c	vijayachitra	IDA		Spectrophotometric authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	InhibitedBy Rv1365c	vijayachitra	IDA		Spectrophotometric authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	Transcription Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002
Interaction	Regulatory Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) EP. Williams, JH. Lee et al. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J. Bacteriol. 2007
Interaction	Transcription Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) EP. Williams, JH. Lee et al. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J. Bacteriol. 2007
Interaction	Regulatory Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007
Interaction	Transcription Rv3286c	hibeeluck	IDA		Co-expression (Functional linkage) S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007
Interaction	Signaling Rv2638	priya.bdu07	IPI		Yeast two-hybrid (Physical interaction) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Signaling Rv1904	kaveri.verma	IPI		yeast two-hybrid system(functional linkage) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv1364c	swetha.r	IDA		authors,MS. Li,SJ. Waddell,IM. Monahan,JA. Mangan,SL. Martin,MJ. Everett,PD. Butcher Increased transcription of a potential sigma factor regulatory gene Rv1364c in Mycobacterium bovis BCG while residing in macrophages indicates use of alternative promoters. FEMS Microbiol. Lett. 2004
Interaction	Regulatory Rv1365c	akankshajain.21	IPI		Yeast two-hybrid (Physical interaction) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv1365c	prabhakarsmail	IPI		Yeast two-hybrid (Physical interaction) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv1364c	swetha.r	IDA		P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008
Interaction	Regulatory Rv1364c	swetha.r	IDA		authors,RK. Jaiswal,G. Manjeera,B. Gopal Role of a PAS sensor domain in the Mycobacterium tuberculosis transcription regulator Rv1364c. Biochemical and biophysical research communications 2010
Interaction	Regulatory Rv0516c	yashabhasin	IPI		Yeast two-hybrid (Physical interaction) AE. Greenstein, JA. MacGurn et al. M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog. PLoS Pathog. 2007
Interaction	Regulatory Rv0516c	yashabhasin	IPI		Yeast two-hybrid (Physical interaction) BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null
Interaction	Regulatory Rv0516c	yashabhasin	IPI		Yeast two-hybrid (Physical interaction) S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007

Property

Value

Creator

Evidence

PMID

Comment

Interaction

Regulatory Rv3687c

akankshajain.21

IPI

Yeast two-hybrid (Physical interaction)
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Structural Analysis
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Structural Analysis
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Structural Analysis
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Structural Analysis
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Structural Analysis
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Citation

Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. J. DeMaio, Y. Zhang et al. Tuber. Lung Dis. 1997

vijayachitra

IDA

9666957

Structural Analysis

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Structural Analysis
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Structural Analysis
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Structural Analysis
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Structural Analysis
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Citation

The sigma factors of Mycobacterium tuberculosis. S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli FEMS Microbiol. Rev. 2006

vijayachitra

IDA

17064287

Structural Analysis

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Structural Analysis
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Citation

Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. BK. Parida, T. Douglas et al. Tuberculosis (Edinburgh, Scotland) null

vijayachitra

IDA

16263329

Structural Analysis

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Structural Analysis
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Structural Analysis
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Structural Analysis
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Structural Analysis
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Citation

Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. P. Sachdeva, A. Narayan et al. FEBS J. 2008

vijayachitra

IDA

19016841

Structural Analysis

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Structural Analysis
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Structural Analysis
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Spectrophotometric
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Spectrophotometric
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Spectrophotometric
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Citation

Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Mol. Microbiol. 2002

vijayachitra

IDA

12354223

Structural Analysis

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Structural Analysis
authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Spectrophotometric
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Citation

Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. J. DeMaio, Y. Zhang et al. Tuber. Lung Dis. 1997

vijayachitra

IDA

9666957

Spectrophotometric

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Spectrophotometric
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Spectrophotometric
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Spectrophotometric
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Spectrophotometric
J. DeMaio, Y. Zhang et al. Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons. Tuber. Lung Dis. 1997

Citation

The sigma factors of Mycobacterium tuberculosis. S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli FEMS Microbiol. Rev. 2006

vijayachitra

IDA

17064287

Spectrophotometric

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Spectrophotometric
S. Rodrigue,R. Provvedi,PE. Jacques,L. Gaudreau,R. Manganelli The sigma factors of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2006

Citation

Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. BK. Parida, T. Douglas et al. Tuberculosis (Edinburgh, Scotland) null

vijayachitra

IDA

16263329

Spectrophotometric

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Spectrophotometric
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Spectrophotometric
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Spectrophotometric
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Spectrophotometric
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Citation

Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. P. Sachdeva, A. Narayan et al. FEBS J. 2008

vijayachitra

IDA

19016841

Spectrophotometric

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Spectrophotometric
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Spectrophotometric
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Spectrophotometric
P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

Regulatory Rv3286c

hibeeluck

IDA

Co-expression (Functional linkage)
authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002

Citation

vijayachitra

IDA

12354223

Spectrophotometric

Interaction

Inhibits Rv3286c

vijayachitra

IDA

Spectrophotometric
authors,J. Beaucher,S. Rodrigue,PE. Jacques,I. Smith,R. Brzezinski,L. Gaudreau Novel Mycobacterium tuberculosis anti-sigma factor antagonists control sigmaF activity by distinct mechanisms. Mol. Microbiol. 2002

Interaction

Inhibits Rv1365c

vijayachitra

IDA

Interaction

InhibitedBy Rv3286c

vijayachitra

IDA

Interaction

InhibitedBy Rv1365c

vijayachitra

IDA

Interaction

Transcription Rv3286c

hibeeluck

IDA

Interaction

Regulatory Rv3286c

hibeeluck

IDA

Co-expression (Functional linkage)
EP. Williams, JH. Lee et al. Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1. J. Bacteriol. 2007

Interaction

Transcription Rv3286c

hibeeluck

IDA

Interaction

Regulatory Rv3286c

hibeeluck

IDA

Co-expression (Functional linkage)
S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007

Interaction

Transcription Rv3286c

hibeeluck

IDA

Co-expression (Functional linkage)
S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007

Interaction

Signaling Rv2638

priya.bdu07

IPI

Interaction

Signaling Rv1904

kaveri.verma

IPI

yeast two-hybrid system(functional linkage)
BK. Parida, T. Douglas et al. Interactions of anti-sigma factor antagonists of Mycobacterium tuberculosis in the yeast two-hybrid system. Tuberculosis (Edinburgh, Scotland) null

Interaction

Regulatory Rv1364c

swetha.r

IDA

authors,MS. Li,SJ. Waddell,IM. Monahan,JA. Mangan,SL. Martin,MJ. Everett,PD. Butcher Increased transcription of a potential sigma factor regulatory gene Rv1364c in Mycobacterium bovis BCG while residing in macrophages indicates use of alternative promoters. FEMS Microbiol. Lett. 2004

Interaction

Regulatory Rv1365c

akankshajain.21

IPI

Interaction

Regulatory Rv1365c

prabhakarsmail

IPI

Interaction

Regulatory Rv1364c

swetha.r

IDA

P. Sachdeva, A. Narayan et al. Loss of kinase activity in Mycobacterium tuberculosis multidomain protein Rv1364c. FEBS J. 2008

Interaction

Regulatory Rv1364c

swetha.r

IDA

authors,RK. Jaiswal,G. Manjeera,B. Gopal Role of a PAS sensor domain in the Mycobacterium tuberculosis transcription regulator Rv1364c. Biochemical and biophysical research communications 2010

Interaction

Regulatory Rv0516c

yashabhasin

IPI

Yeast two-hybrid (Physical interaction)
AE. Greenstein, JA. MacGurn et al. M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog. PLoS Pathog. 2007

Interaction

Regulatory Rv0516c

yashabhasin

IPI

Interaction

Regulatory Rv0516c

yashabhasin

IPI

Yeast two-hybrid (Physical interaction)
S. Dhandayuthapani Stress response of genes encoding putative stress signaling molecules of Mycobacterium tuberculosis. Front. Biosci. 2007

Comments