Rv2973c (recG)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: ATP-dependent DNA helicase recG
- REFSEQ: ATP-dependent DNA helicase RecG
- PATRIC: ATP-dependent DNA helicase RecG (EC 3.6.1.-)
- TUBERCULIST: Probable ATP-dependent DNA helicase RecG
- NCBI: Probable ATP-dependent DNA helicase RecG
- updated information (H37Rv4):
  - gene name: recG
  - function:
  - reference:
Type: Not Target
Start: 3327733
End: 3329946
Operon:

Trans-membrane region:
Role: II.A.5 - DNA replication, repair, recombination and restriction/modification
GO terms:
- GO:0032508 - DNA duplex unwinding (Uniprot)
- GO:0016787 - hydrolase activity (Uniprot)
- GO:0010501 - RNA secondary structure unwinding (Uniprot)
- GO:0006974 - cellular response to DNA damage stimulus (Uniprot)
- GO:0006310 - DNA recombination (Uniprot)
- GO:0006281 - DNA repair (Uniprot)
- GO:0005886 - plasma membrane (Uniprot)
- GO:0005737 - cytoplasm (Uniprot)
- GO:0005524 - ATP binding (Uniprot)
- GO:0004386 - helicase activity (Uniprot)
- GO:0004004 - ATP-dependent RNA helicase activity (Uniprot)
- GO:0004003 - ATP-dependent DNA helicase activity (Uniprot)
- GO:0003677 - DNA binding (Uniprot)
- GO:0003676 - nucleic acid binding (Uniprot)
- GO:0000166 - nucleotide binding (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB
Top 10 Homologs in PDB (as of Nov 2020):

PDB aa ident species PDB title

1GM5 35% THERMOTOGA MARITIMA Structure of RecG bound to three-way DNA junction
Links to additional information on recG:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = -0.515 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

PDB	aa ident	species	PDB title
1GM5	35%	THERMOTOGA MARITIMA	Structure of RecG bound to three-way DNA junction

Amino Acid Sequence

VASLSDRLDRVLGATAADALDEQFGMRTVDDLLRHYPRSYVEGAARVGIGDARPEAGEHITIVDVITDTYSFPMKKKPNRKCLRITVGGGRNKVTATFFN
ADYIMRDLTKHTKVMLSGEVGYYKGAMQLTHPAFLILDSPDGKNHGTRSLKSIADASKAISGELVVEEFERRFFPIYPASTKVQSWDIFKCVRQVLDVLD
RVDDPLPAELRAKHGLIPEDEALRAIHLAESQSLRERARERLTFDEAVGLQWALVARRHGELSESGPSAAWKSNGLAAELLRRLPFELTAGQREVLDVLS
DGLAANRPLNRLLQGEVGSGKTIVAVLAMLQMVDAGYQCALLAPTEVLAAQHLRSIRDVLGPLAMGGQLGGAENATRVALLTGSMTAGQKKQVRAEIASG
QVGIVIGTHALLQEAVDFHNLGMVVVDEQHRFGVEQRDQLRAKAPAGITPHLLVMTATPIPRTVALTVYGDLETSTLRELPLGRQPIATNVIFVKDKPAW
LDRAWRRIIEEAAAGRQAYVVAPRIDESDDTDVQGGVRPSATAEGLFSRLRSAELAELRLALMHGRLSADDKDAAMAAFRAGEVDVLVCTTVIEVGVDVP
NATVMLVMDADRFGISQLHQLRGRIGRGEHPSVCLLASWVPPDTPAGQRLRAVAGTMDGFALADLDLKERKEGDVLGRNQSGKAITLRLLSLAEHEEYIV
AARDFCIEAYKNPTDPALALMAARFTSTDRIEYLDKS

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Uncertain	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.560300; 8 non-insertions in a row out of 30 sites
Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.993150; 10 non-insertions in a row out of 30 sites
Uncertain	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.444550; 6 non-insertions in a row out of 30 sites
Uncertain	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.977500; 9 non-insertions in a row out of 30 sites
Uncertain	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.986150; 10 non-insertions in a row out of 30 sites
Non-Essential	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Non-Essential	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: 1.56
Non-Essential	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Binds To:
- No bindings to other targets were found.
Bound By:

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- No bindings to other targets were found.

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Rv0818 (-)
Downregulates:
- Does not downregulate other genes.
Downregulated by:

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv2973c (recG)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Citation	Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik J. Exp. Med. 2003	shahanup86	ISS	12953091	Structural Analysis
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Citation	Situational repair of replication forks: roles of RecG and RecA proteins. authors,ME. Robu,RB. Inman,MM. Cox J. Biol. Chem. 2004	shahanup86	ISS	14701860	Structural Analysis
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Citation	Characterisation of the catalytically active form of RecG helicase. authors,P. McGlynn,AA. Mahdi,RG. Lloyd Nucleic Acids Res. 2000	shahanup86	ISS	10871364	Structural Analysis
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Citation	Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Mol. Cell 2002	shahanup86	ISS	11864599	Structural Analysis
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Citation	Structural analysis of DNA replication fork reversal by RecG. authors,MR. Singleton,S. Scaife,DB. Wigley Cell 2001	shahanup86	ISS	11595187	Structural Analysis
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Citation	Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik J. Exp. Med. 2003	shahanup86	ISS	12953091	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Citation	Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. authors,GJ. Sharples,SM. Ingleston,RG. Lloyd J. Bacteriol. 1999	shahanup86	ISS	10482492	Structural Analysis
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Citation	Characterisation of the catalytically active form of RecG helicase. authors,P. McGlynn,AA. Mahdi,RG. Lloyd Nucleic Acids Res. 2000	shahanup86	ISS	10871364	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Citation	Situational repair of replication forks: roles of RecG and RecA proteins. authors,ME. Robu,RB. Inman,MM. Cox J. Biol. Chem. 2004	shahanup86	ISS	14701860	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Citation	Structural analysis of DNA replication fork reversal by RecG. authors,MR. Singleton,S. Scaife,DB. Wigley Cell 2001	shahanup86	ISS	11595187	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv1402	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Citation	Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Mol. Cell 2002	shahanup86	ISS	11864599	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Citation	Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. authors,GJ. Sharples,SM. Ingleston,RG. Lloyd J. Bacteriol. 1999	shahanup86	ISS	10482492	Spectrophotometric
Interaction	PhysicalInteraction Rv2593c	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2592c	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2594c	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2737c	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Other	TBPWY:Recombination repair	vmizrahi			Increased expression in Mtb from clinical lung samples
Other	TBPWY:Recombination repair	vmizrahi			Upregulated following infection of nave and activated mouse macrophages

Property

Value

Creator

Evidence

PMID

Comment

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Citation

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik J. Exp. Med. 2003

shahanup86

ISS

12953091

Structural Analysis

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Citation

Situational repair of replication forks: roles of RecG and RecA proteins. authors,ME. Robu,RB. Inman,MM. Cox J. Biol. Chem. 2004

shahanup86

ISS

14701860

Structural Analysis

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Citation

Characterisation of the catalytically active form of RecG helicase. authors,P. McGlynn,AA. Mahdi,RG. Lloyd Nucleic Acids Res. 2000

shahanup86

ISS

10871364

Structural Analysis

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Citation

Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Mol. Cell 2002

shahanup86

ISS

11864599

Structural Analysis

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Citation

Structural analysis of DNA replication fork reversal by RecG. authors,MR. Singleton,S. Scaife,DB. Wigley Cell 2001

shahanup86

ISS

11595187

Structural Analysis

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Citation

shahanup86

ISS

12953091

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Citation

Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. authors,GJ. Sharples,SM. Ingleston,RG. Lloyd J. Bacteriol. 1999

shahanup86

ISS

10482492

Structural Analysis

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Citation

Characterisation of the catalytically active form of RecG helicase. authors,P. McGlynn,AA. Mahdi,RG. Lloyd Nucleic Acids Res. 2000

shahanup86

ISS

10871364

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Citation

Situational repair of replication forks: roles of RecG and RecA proteins. authors,ME. Robu,RB. Inman,MM. Cox J. Biol. Chem. 2004

shahanup86

ISS

14701860

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Citation

Structural analysis of DNA replication fork reversal by RecG. authors,MR. Singleton,S. Scaife,DB. Wigley Cell 2001

shahanup86

ISS

11595187

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv1402

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Citation

Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Mol. Cell 2002

shahanup86

ISS

11864599

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Citation

Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. authors,GJ. Sharples,SM. Ingleston,RG. Lloyd J. Bacteriol. 1999

shahanup86

ISS

10482492

Spectrophotometric

Interaction

PhysicalInteraction Rv2593c

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2592c

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2594c

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2737c

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Other

TBPWY:Recombination repair

vmizrahi

Increased expression in Mtb from clinical lung samples

Other

TBPWY:Recombination repair

vmizrahi

Upregulated following infection of nave and activated mouse macrophages

Comments