TB Genome Annotation Portal

Rv2855 (mtr)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: mycothione reductase
  • REFSEQ: mycothione reductase
  • PATRIC: NADPH-dependent mycothiol reductase Mtr
  • TUBERCULIST: NADPH-dependent mycothiol reductase Mtr
  • NCBI: NADPH-dependent mycothiol reductase Mtr
  • updated information (H37Rv4):
    • gene name: mtr
    • function:
    • reference:
• Type: Not Target
• Start: 3165205
• End: 3166584
• Operon:


• Trans-membrane region:
  
• Role: I.G.10 - Thioredoxin, glutaredoxin and mycothiol
• GO terms:
  • GO:0070402 - NADPH binding (Uniprot)
  • GO:0055114 - oxidation-reduction process (Uniprot)
  • GO:0050660 - flavin adenine dinucleotide binding (Uniprot)
  • GO:0050627 - mycothione reductase activity (Uniprot)
  • GO:0045454 - cell redox homeostasis (Uniprot)
  • GO:0040007 - growth (Uniprot)
  • GO:0022900 - electron transport chain (Uniprot)
  • GO:0016668 - oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor (Uniprot)
  • GO:0016491 - oxidoreductase activity (Uniprot)
  • GO:0010126 - mycothiol metabolic process (Uniprot)
  • GO:0009055 - electron transfer activity (Uniprot)
  • GO:0005829 - cytosol (Uniprot)
  • GO:0005515 - protein binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • NADP[c] + MYCOTHIOL[c] <=> H[c] + NADPH[c] + MYCOTHIOL_S_CONJUGATE[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
• Links to additional information on mtr:
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = 2.077 (from Jeremy Rock's lab)

Amino Acid Sequence

METYDIAIIGTGSGNSILDERYASKRAAICEQGTFGGTCLNVGCIPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALSGEDYRR
CAPNIDVYRTHTRFGPVQADGRYLLRTDAGEEFTAEQVVIAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAHVFSALGVRVTL
VIRGSCLLRHCDDTICERFTRIASTKWELRTHRNVVDGQQRGSGVALRLDDGCTINADLLLVATGRVSNADLLDAEQAGVDVEDGRVIVDEYQRTSARGV
FALGDVSSPYLLKHVANHEARVVQHNLLCDWEDTQSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAYGWAMEDTSGIVKLITE
RGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAAEMARGQYWIHPALPEVVENALLGLR

Additional Information