TB Genome Annotation Portal

Rv2691 (ceoB)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: trk system potassium uptake protein TrkA
  • REFSEQ: TRK system potassium uptake protein CEOB
  • PATRIC: Trk system potassium uptake protein TrkA
  • TUBERCULIST: TRK system potassium uptake protein CeoB
  • NCBI: TRK system potassium uptake protein CeoB
  • updated information (H37Rv4):
    • gene name: ceoB
    • function:
    • reference:
• Type: Not Target
• Start: 3009344
• End: 3010027
• Operon:


• Trans-membrane region:
  
• Role: III.A.2 - Cations
• GO terms:
  • GO:0098655 - cation transmembrane transport (Uniprot)
  • GO:0071805 - potassium ion transmembrane transport (Uniprot)
  • GO:0015079 - potassium ion transmembrane transporter activity (Uniprot)
  • GO:0008324 - cation transmembrane transporter activity (Uniprot)
  • GO:0006813 - potassium ion transport (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  6VPB	40%	Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5)	A novel membrane-bound 6-phosphogluconate dehydrogenase from the acetic acid bacteria Gluconacetobacter diazotrophicus (Gd6PGD)
  3L4B	35%	Thermotoga maritima	Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima
  2G1U	35%	Thermotoga maritima	CRYSTAL STRUCTURE OF A PUTATIVE TRANSPORT PROTEIN (TM1088A) FROM THERMOTOGA MARITIMA AT 1.50 A RESOLUTION

• Links to additional information on ceoB:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -0.604 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MRVVVMGCGRVGASVADGLSRIGHEVAIIDRDSAAFNRLSPQFAGERVLGQGFDRDVLLRAGIQGADAFAAVSSGDNSNIISARLARETFGVPRVVARIY
DAKRAEVYERLGIPTITTVPWTTDRLLNALMQDTETAKWRDPTGTVAVAEVVLHEDWVGHRATDLEQATGARIAFLIRFGTGVLPEPKTVLQAGDKVYIA
AISGRAAEAAAIAALPPSEDFESGARR

Additional Information