TB Genome Annotation Portal

Rv2550c (vapB20)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: antitoxin
  • REFSEQ: hypothetical protein
  • PATRIC: DNA-binding protein CopG family
  • TUBERCULIST: Possible antitoxin VapB20
  • NCBI: Possible antitoxin VapB20
  • updated information (H37Rv4):
    • gene name: vapB20
    • function:
    • reference:
• Type: Not Target
• Start: 2870119
• End: 2870364
• Operon:


• Trans-membrane region:
  
• Role: VI - Unknowns
• GO terms:
  • GO:0097351 - toxin-antitoxin pair type II binding (Uniprot)
  • GO:0045927 - positive regulation of growth (Uniprot)
  • GO:0006355 - regulation of transcription, DNA-templated (Uniprot)
  • GO:0005515 - protein binding (Uniprot)
  • GO:0003677 - DNA binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
• Links to additional information on vapB20:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = 1.12 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKHE

Additional Information