TB Genome Annotation Portal

Rv1621c (cydD)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: thiol reductant ABC exporter CydD subunit
  • REFSEQ: vytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
  • PATRIC: Transport ATP-binding protein CydD
  • TUBERCULIST: Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
  • NCBI: Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD
  • updated information (H37Rv4):
    • gene name: cydD
    • function:
    • reference:
• Type: Not Target
• Start: 1821690
• End: 1823273
• Operon:


• Trans-membrane region:
  
• Role: I.B.6.c - Electron transport
• GO terms:
  • GO:0055085 - transmembrane transport (Uniprot)
  • GO:0042883 - cysteine transport (Uniprot)
  • GO:0042626 - ATPase activity, coupled to transmembrane movement of substances (Uniprot)
  • GO:0034040 - lipid-transporting ATPase activity (Uniprot)
  • GO:0016887 - ATPase activity (Uniprot)
  • GO:0016021 - integral component of membrane (Uniprot)
  • GO:0016020 - membrane (Uniprot)
  • GO:0006869 - lipid transport (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005524 - ATP binding (Uniprot)
  • GO:0000166 - nucleotide binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  6TEJ	38%	Mycolicibacterium thermoresistibile	Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5
  4AYX	37%	HOMO SAPIENS	STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B)
  4AYT	37%	HOMO SAPIENS	STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
  3ZDQ	37%	HOMO SAPIENS	STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (NUCLEOTIDE-FREE FORM)
  4AYW	37%	HOMO SAPIENS	STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
  6S7P	36%	Homo sapiens	Nucleotide bound ABCB4
  6LR0	35%	Homo sapiens	structure of human bile salt exporter ABCB11
  5U1D	35%	Homo sapiens	Cryo-EM structure of the human TAP ATP-Binding Cassette Transporter
  6JB3	35%	Mesocricetus auratus	Structure of SUR1 subunit bound with repaglinide
  6JB1	35%	Mesocricetus auratus	Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution

• Links to additional information on cydD:
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -2.565 (from Jeremy Rock's lab)
  • BioCyc
  • Systems Biology

Amino Acid Sequence

VACGVGISGCAIGSAIVLASIVAGVIDPANPGMAGLRRWLGPLSILLVLWGLRASIQWLQARLAQRGASAVIADLSGQVLTAVTARRPSQLAAQRDAAAV
LITRGLDGLRPYFTGYLPTLLLAAILTPATVAVIGLYDLKSMAIVVITLPLIPIFMVLIGLATTNPSAAALAAMTAVQARLLDLIAGIPTLRALGRASGP
EQRIAELSADHRRSAMATLRIAFLSALVLELLATLGVALVAVGIGLRLVFGEMSLTAGLTVLLLAPEVYWPLRRVGVQFHAAADGRTAADKAFALLGESP
SPTPGRRTVTARGGVIRLERLSVRGRDGRAPYDLTADIEPGRVTVLTGRNGAGKSTTLQAIAGLTAPSSGRITVAGVDVTNLAPAAWWRQLSWLPQRPVL
VPGTVRHNLVLLGPVDDLERACAAAGFDAVLDELPRGLDTVLGRGGVGLSLGQRQRLGLARALGSPAAVLLLDEPTAHLDARTEQHVLGAIVERARAGAT
VLVVAHRQQVAAAGDRVVEVNSDGFRR

Additional Information