TB Genome Annotation Portal

Rv1319c (-)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: adenylate cyclase
  • REFSEQ: adenylate cyclase
  • PATRIC: Adenylate cyclase (EC 4.6.1.1)
  • TUBERCULIST: Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
  • NCBI: Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
  • updated information (H37Rv4):
    • gene name: -
    • function:
    • reference:
• Type: Not Target
• Start: 1480894
• End: 1482501
• Operon:


• Trans-membrane region:
  
• Role: IV.J - Cyclases
• GO terms:
  • GO:0035556 - intracellular signal transduction (Uniprot)
  • GO:0016849 - phosphorus-oxygen lyase activity (Uniprot)
  • GO:0016021 - integral component of membrane (Uniprot)
  • GO:0016020 - membrane (Uniprot)
  • GO:0009190 - cyclic nucleotide biosynthetic process (Uniprot)
  • GO:0007165 - signal transduction (Uniprot)
  • GO:0006171 - cAMP biosynthetic process (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005622 - intracellular (Uniprot)
  • GO:0005576 - extracellular region (Uniprot)
  • GO:0004871 - signal transducer activity (Uniprot)
  • GO:0004016 - adenylate cyclase activity (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • ATP[c] -> PPI[c] + cAMP[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  5O5L	35%	Mycobacterium intracellulare 1956	X-ray structure of a bacterial adenylyl cyclase soluble domain, solved at cryogenic temperature
  5O5K	35%	Mycobacterium intracellulare 1956	X-ray structure of a bacterial adenylyl cyclase soluble domain

• Links to additional information on Rv1319c:
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = 0.948 (from Jeremy Rock's lab)

Amino Acid Sequence

MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYAT
LALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVA
AKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR
GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDR
HHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASS
DTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT

Additional Information