TB Genome Annotation Portal

Rv1163 (narJ)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: nitrate reductase molybdenum cofactor assembly chaperone
  • REFSEQ: respiratory nitrate reductase subunit delta NarJ
  • PATRIC: Respiratory nitrate reductase delta chain (EC 1.7.99.4)
  • TUBERCULIST: Probable respiratory nitrate reductase (delta chain) NarJ
  • NCBI: Probable respiratory nitrate reductase (delta chain) NarJ
  • updated information (H37Rv4):
    • gene name: narJ
    • function:
    • reference:
• Type: Not Target
• Start: 1292798
• End: 1293403
• Operon:


• Trans-membrane region:
  
• Role: I.B.6.b - anaerobic
• GO terms:
  • GO:0051131 - chaperone-mediated protein complex assembly (Uniprot)
  • GO:0051082 - unfolded protein binding (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • MKH2[c] + 0.001 MOLYBDENUM[c] + NO3[c] -> 2 H[c] + MK[c] + NO2[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
• Links to additional information on narJ:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = 0.207 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

VWQSASLLLAYPDDGLAERLHMVDALRAHQTGPAAALLGRTVAELRALAPMAAAAQYVETFDMRRRSTMYLTYWTAGDTRNRGREMLAFATAYRDAGVKP
PRTEAPDYLPVVLEFAATVDPEAGRRLLTEHRVPIDVLRGALADAKSPYEYTVAAICETLPAATNQEVRRAQRLAQSGPPAEAVGLQPFTLTVPPKRAEG
A

Additional Information