| Property | Value | Creator | Evidence | PMID | Comment |
| Citation | Mycothiol biochemistry. GL. Newton & RC. Fahey Arch. Microbiol. 2002 | njamshidi | ISS | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISS | njamshidi | ISS | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton & RC. Fahey Mycothiol biochemistry. Arch. Microbiol. 2002 |
| Citation | A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. GL. Newton, Y. Av-Gay et al. Biochemistry 2000 | njamshidi | ISS | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISS | njamshidi | ISS | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton, Y. Av-Gay et al. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 2000 |
| Citation | Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. M. Steffek, GL. Newton et al. Biochemistry 2003 | njamshidi | ISS | 12420157|14556638|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - ISS | njamshidi | ISS | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
M. Steffek, GL. Newton et al. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry 2003 |
| Citation | Mycothiol biochemistry. GL. Newton & RC. Fahey Arch. Microbiol. 2002 | njamshidi | IDA | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDA | njamshidi | IDA | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton & RC. Fahey Mycothiol biochemistry. Arch. Microbiol. 2002 |
| Citation | A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. GL. Newton, Y. Av-Gay et al. Biochemistry 2000 | njamshidi | IDA | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDA | njamshidi | IDA | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
GL. Newton, Y. Av-Gay et al. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 2000 |
| Citation | Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. M. Steffek, GL. Newton et al. Biochemistry 2003 | njamshidi | IDA | 12420157|14556638|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction. |
| Term | TBRXN:MSHAMID conjugated glutathione amidase (Mtb) - IDA | njamshidi | IDA | 12420157|10978158 | See PMID: 12420157, 10978158 - bimane is just an example of a 'toxin' that conjugates with mycothiol. Has been used experimentally (actually monobromobimane used in the experiments but for simplicity [to avoid additional Br transport], just bimane used - also note that this will disrupt the charge balance for bmnmsh synthesis rxn: BMNMSH). Also PMID 14556638 - multiple drugs can bind mycothiol, and MCA appears to be able to hydrolyze the bonds for many of them. More detailed describes are out of the scope of the current reconstruction.
M. Steffek, GL. Newton et al. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry 2003 |
