TB Genome Annotation Portal

Rv1005c (pabB)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: aminodeoxychorismate synthase component I
  • REFSEQ: aminodeoxychorismate synthase component I
  • PATRIC: Para-aminobenzoate synthase aminase component (EC 2.6.1.85)
  • TUBERCULIST: Probable para-aminobenzoate synthase component I PABD
  • NCBI: Probable para-aminobenzoate synthase component I PABD
  • updated information (H37Rv4):
    • gene name: pabB
    • function:
    • reference:
• Type: Not Target
• Start: 1122222
• End: 1123598
• Operon:


• Trans-membrane region:
  
• Role: I.G.2 - Folic acid
• GO terms:
  • GO:0046820 - 4-amino-4-deoxychorismate synthase activity (Uniprot)
  • GO:0046654 - tetrahydrofolate biosynthetic process (Uniprot)
  • GO:0040007 - growth (Uniprot)
  • GO:0009396 - folic acid-containing compound biosynthetic process (Uniprot)
  • GO:0009058 - biosynthetic process (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005737 - cytoplasm (Uniprot)
  • GO:0005618 - cell wall (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  1K0G	42%	Escherichia coli	THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM PHOSPHATE GROWN CRYSTALS
  1K0E	42%	Escherichia coli	THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM FORMATE GROWN CRYSTALS
  1I1Q	36%	Salmonella typhimurium	STRUCTURE OF THE COOPERATIVE ALLOSTERIC ANTHRANILATE SYNTHASE FROM SALMONELLA TYPHIMURIUM
  4GRH	36%	Stenotrophomonas maltophilia	Crystal structure of pabB of Stenotrophomonas maltophilia
  1QDL	35%	Sulfolobus solfataricus	THE CRYSTAL STRUCTURE OF ANTHRANILATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS

• Links to additional information on pabB:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -4.066 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

LNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAVLRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPD
ATGAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADWLASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLE
AIGAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDL
VRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVPLEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVAI
RTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTPARLASKVR

Additional Information