TB Genome Annotation Portal

Rv0951 (sucC)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: succinyl-CoA ligase [ADP-forming] subunit beta
  • REFSEQ: succinyl-CoA synthetase subunit beta
  • PATRIC: Succinyl-CoA ligase [ADP-forming] beta chain (EC 6.2.1.5)
  • TUBERCULIST: Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta)
  • NCBI: Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta)
  • updated information (H37Rv4):
    • gene name: sucC
    • function:
    • reference:
• Type: Not Target
• Start: 1061964
• End: 1063127
• Operon:


• Trans-membrane region:
  
• Role: I.B.3 - TCA cycle
• GO terms:
  • GO:0046872 - metal ion binding (Uniprot)
  • GO:0040007 - growth (Uniprot)
  • GO:0016874 - ligase activity (Uniprot)
  • GO:0008152 - metabolic process (Uniprot)
  • GO:0006099 - tricarboxylic acid cycle (Uniprot)
  • GO:0005829 - cytosol (Uniprot)
  • GO:0005618 - cell wall (Uniprot)
  • GO:0005524 - ATP binding (Uniprot)
  • GO:0004775 - succinate-CoA ligase (ADP-forming) activity (Uniprot)
  • GO:0003824 - catalytic activity (Uniprot)
  • GO:0000166 - nucleotide binding (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • ADP[c] + PI[c] + SUCCOA[c] <=> ATP[c] + COA[c] + SUCC[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  3UFX	51%	Thermus aquaticus	Thermus aquaticus succinyl-CoA synthetase in complex with GDP-Mn2+
  2SCU	41%	Escherichia coli	A detailed description of the structure of Succinyl-COA synthetase from Escherichia coli
  2NUA	41%	Escherichia coli	C123aV Mutant of E. coli Succinyl-CoA Synthetase
  2NU9	41%	Escherichia coli	C123aT Mutant of E. coli Succinyl-CoA Synthetase Orthorhombic Crystal Form
  2NU8	41%	Escherichia coli	C123aT Mutant of E. coli Succinyl-CoA Synthetase
  2NU7	41%	Escherichia coli	C123aS Mutant of E. coli Succinyl-CoA Synthetase
  2NU6	41%	Escherichia coli	C123aA Mutant of E. coli Succinyl-CoA Synthetase
  1SCU	41%	Escherichia coli	THE CRYSTAL STRUCTURE OF SUCCINYL-COA SYNTHETASE FROM ESCHERICHIA COLI AT 2.5 ANGSTROMS RESOLUTION
  1JKJ	41%	Escherichia coli	E. coli SCS
  1CQJ	41%	Escherichia coli	CRYSTAL STRUCTURE OF DEPHOSPHORYLATED E. COLI SUCCINYL-COA SYNTHETASE

• Links to additional information on sucC:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -4.624 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEY
YLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHK
ILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLD
VVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA

Additional Information