TB Genome Annotation Portal

Rv0707 (rpsC)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: 30S ribosomal protein S3
  • REFSEQ: 30S ribosomal protein S3
  • PATRIC: SSU ribosomal protein S3p (S3e)
  • TUBERCULIST: 30S ribosomal protein S3 RpsC
  • NCBI: 30S ribosomal protein S3 RpsC
  • updated information (H37Rv4):
    • gene name: rpsC
    • function:
    • reference:
• Type: Not Target
• Start: 804282
• End: 805106
• Operon:


• Trans-membrane region:
  
• Role: II.A.1 - Ribosomal protein synthesis and modification
• GO terms:
  • GO:0040007 - growth (Uniprot)
  • GO:0030529 - not-found (Uniprot)
  • GO:0022627 - cytosolic small ribosomal subunit (Uniprot)
  • GO:0019843 - rRNA binding (Uniprot)
  • GO:0015935 - small ribosomal subunit (Uniprot)
  • GO:0006412 - translation (Uniprot)
  • GO:0005886 - plasma membrane (Uniprot)
  • GO:0005840 - ribosome (Uniprot)
  • GO:0005618 - cell wall (Uniprot)
  • GO:0003735 - structural constituent of ribosome (Uniprot)
  • GO:0003723 - RNA binding (Uniprot)
  • GO:0003676 - nucleic acid binding (Uniprot)
  • GO:0002181 - cytoplasmic translation (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  5V93	100%	Mycobacterium tuberculosis	Cryo-EM structure of the 70S ribosome from Mycobacterium tuberculosis bound with Capreomycin
  6DZI	97%	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex
  6DZK	90%	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	Cryo-EM Structure of Mycobacterium smegmatis C(minus) 30S ribosomal subunit with MPY
  5ZEU	90%	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	M. smegmatis P/P state 30S ribosomal subunit
  5ZEP	90%	Mycobacterium smegmatis str. MC2 155	M. smegmatis hibernating state 70S ribosome structure
  5ZEB	90%	Mycobacterium smegmatis str. MC2 155	M. Smegmatis P/P state 70S ribosome structure
  5XYU	90%	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	Small subunit of Mycobacterium smegmatis ribosome
  5O61	90%	Mycobacterium smegmatis str. MC2 155	The complete structure of the Mycobacterium smegmatis 70S ribosome
  5O5J	90%	Mycobacterium smegmatis str. MC2 155	Structure of the 30S small ribosomal subunit from Mycobacterium smegmatis
  6WUA	56%	Enterococcus faecalis OG1RF	30S subunit (head) of 70S Ribosome Enterococcus faecalis MultiBody refinement

• Links to additional information on rpsC:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -14.65 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology
  • Photo of spot titer

Amino Acid Sequence

VGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSSGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQL
NILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKV
WIYKGDIVGGKRELAAAAPAGADRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES

Additional Information