Rv0590A (-)

Current annotations:
- TUBERCULIST: Mce-family related protein
- NCBI: Mce-family related protein
- updated information (H37Rv4):
  - gene name: -
  - function:
  - reference:
Type: Not Target
Start: 688808
End: 689062
Operon:

Trans-membrane region:
Role: -
GO terms:
- No terms assigned.
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB
Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
Links to additional information on Rv0590A:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = 1.569 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

LLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPTGRCTPQ

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Non-Essential	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 2 non-insertions in a row out of 7 sites
Non-Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 2 non-insertions in a row out of 7 sites
Non-Essential	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.000000; 2 non-insertions in a row out of 7 sites
Too-Short	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: -1.000000; 2 non-insertions in a row out of 6 sites
Too-Short	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: -1.000000; 3 non-insertions in a row out of 6 sites
No-Data	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Too-Short	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: -1
Non-Essential	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Binds To:
- No bindings to other targets were found.
Bound By:

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- No bindings to other targets were found.

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Rv0818 (-)
Downregulates:
- Does not downregulate other genes.
Downregulated by:
- Rv0586 (mce2R)
- Rv2595 (vapB40)

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv0590A (-)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) authors,M. Alonso-Hearn,TM. Eckstein,S. Sommer,LE. Bermudez A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence. Innate Immun 2010
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Citation	Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). Y. Haile, DA. Caugant et al. FEMS Immunol. Med. Microbiol. 2002	kholia.trupti	IEP	12052567	Co-expression (Functional linkage)
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0591	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0592	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0593	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0594	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Citation	Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Tuberculosis (Edinb) 2010	kholia.trupti	IEP	19963438	Co-expression (Functional linkage)
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Citation	Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. authors,A. Kumar,M. Bose,V. Brahmachari Infect. Immun. 2003	kholia.trupti	IEP	14500535	Co-expression (Functional linkage)
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0590	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) AK. Das, D. Mitra et al. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 2003
Interaction	Operon Rv0589	kholia.trupti	IEP		Co-expression (Functional linkage) D. Mitra, B. Saha et al. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis performing homology modeling. Tuberculosis (Edinburgh, Scotland) null

Property

Value

Creator

Evidence

PMID

Comment

Interaction

Operon Rv0594

kholia.trupti

IEP

Co-expression (Functional linkage)
Y. Haile, DA. Caugant et al. Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol. Med. Microbiol. 2002

Interaction

Operon Rv0594

kholia.trupti

IEP

Co-expression (Functional linkage)
O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. Tuberculosis (Edinb) 2010

Interaction

Operon Rv0594

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0593

kholia.trupti

IEP

Interaction

Operon Rv0593

kholia.trupti

IEP

Interaction

Operon Rv0593

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0593

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,M. Alonso-Hearn,TM. Eckstein,S. Sommer,LE. Bermudez A Mycobacterium avium subsp. paratuberculosis LuxR regulates cell envelope and virulence. Innate Immun 2010

Interaction

Operon Rv0592

kholia.trupti

IEP

Interaction

Operon Rv0592

kholia.trupti

IEP

Interaction

Operon Rv0592

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0591

kholia.trupti

IEP

Interaction

Operon Rv0591

kholia.trupti

IEP

Interaction

Operon Rv0591

kholia.trupti

IEP

Interaction

Operon Rv0592

kholia.trupti

IEP

Interaction

Operon Rv0593

kholia.trupti

IEP

Interaction

Operon Rv0594

kholia.trupti

IEP

Interaction

Operon Rv0591

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0591

kholia.trupti

IEP

Interaction

Operon Rv0592

kholia.trupti

IEP

Interaction

Operon Rv0593

kholia.trupti

IEP

Interaction

Operon Rv0594

kholia.trupti

IEP

Citation

Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT). Y. Haile, DA. Caugant et al. FEMS Immunol. Med. Microbiol. 2002

kholia.trupti

IEP

12052567

Co-expression (Functional linkage)

Interaction

Operon Rv0590

kholia.trupti

IEP

Interaction

Operon Rv0589

kholia.trupti

IEP

Interaction

Operon Rv0589

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0591

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0592

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0593

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0594

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Citation

Mce2 operon mutant strain of Mycobacterium tuberculosis is attenuated in C57BL/6 mice. O. Marjanovic,T. Miyata,A. Goodridge,LV. Kendall,LW. Riley Tuberculosis (Edinb) 2010

kholia.trupti

IEP

19963438

Co-expression (Functional linkage)

Interaction

Operon Rv0590

kholia.trupti

IEP

Interaction

Operon Rv0589

kholia.trupti

IEP

Interaction

Operon Rv0590

kholia.trupti

IEP

Citation

Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. authors,A. Kumar,M. Bose,V. Brahmachari Infect. Immun. 2003

kholia.trupti

IEP

14500535

Co-expression (Functional linkage)

Interaction

Operon Rv0590

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0590

kholia.trupti

IEP

Interaction

Operon Rv0590

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0589

kholia.trupti

IEP

Interaction

Operon Rv0589

kholia.trupti

IEP

Interaction

Operon Rv0589

kholia.trupti

IEP

Co-expression (Functional linkage)
authors,A. Kumar,M. Bose,V. Brahmachari Analysis of expression profile of mammalian cell entry (mce) operons of Mycobacterium tuberculosis. Infect. Immun. 2003

Interaction

Operon Rv0589

kholia.trupti

IEP

Co-expression (Functional linkage)
AK. Das, D. Mitra et al. Predicted molecular structure of the mammalian cell entry protein Mce1A of Mycobacterium tuberculosis. Biochem. Biophys. Res. Commun. 2003

Interaction

Operon Rv0589

kholia.trupti

IEP

Co-expression (Functional linkage)
D. Mitra, B. Saha et al. Correlating sequential homology of Mce1A, Mce2A, Mce3A and Mce4A with their possible functions in mammalian cell entry of Mycobacterium tuberculosis performing homology modeling. Tuberculosis (Edinburgh, Scotland) null

Comments