gene wt1 wt2 wt3 ko1 ko2 ko3 DESeq2.baseMean DESeq2.log2FoldChange DESeq2.lfcSE DESeq2.stat DESeq2.pvalue DESeq2.padj annot funcat Rv0001 dnaA 100.3 114.9 71.2 85.1 177.2 183.7 307.341363137222 0.434933557072665 0.321609035814335 1.35236734245163 0.176257831203255 0.734764437650925 Chromosomal replication initiator protein DnaA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0002 dnaN 50.2 36.2 21.1 78.9 50 59.6 93.1486453588508 0.671976991100276 0.283589449540244 2.36954157564637 0.0178101525675375 0.276757764055105 DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0003 recF 84.8 63.7 66.3 106.9 100.5 86.2 159.127675971809 0.222639376786476 0.250509432974929 0.888746480092661 0.374139345030243 0.887356086865747 DNA replication and repair protein RecF (single-strand DNA binding protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0004 - 83.9 40.9 36 100 89.8 62.6 59.421868224126 0.485554829443442 0.313589322194607 1.548378069908 0.121531298001464 0.665646250765128 hypothetical protein V - Conserved hypotheticals Rv0005 gyrB 1184.4 859 880.7 739.2 951.7 828.7 3059.47669060533 -0.434007037316077 0.212120860541391 -2.04603656711731 0.0407527730898081 0.409898801332397 DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0006 gyrA 716.7 441.6 450.2 560.9 584.1 505.6 2221.25904073722 -0.159959407915829 0.178695104715632 -0.895152713726442 0.370705458298154 0.885048465556592 DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0007 - 250.7 156.6 101 254.9 192 213.4 280.532328122916 0.236868331716096 0.212548872959164 1.11441819671095 0.265099820436695 0.80816433845196 Possible conserved membrane protein V - Conserved hypotheticals Rv0008c - 29.1 6.1 12.3 10.2 32.7 6.8 9.9282438826608 -0.246407111019717 0.756114283002133 -0.32588606849399 0.744510556549537 NA Possible membrane protein VI - Unknowns Rv0009 ppiA 297.6 187.1 151.7 198.3 271.8 247.2 198.882783116501 -0.0108429652158035 0.241480220881663 -0.0449020842212872 0.964185355553611 0.998153412295216 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) II.A.6 - Protein translation and modification Rv0010c - 161.6 90.7 64.8 103.1 114.6 74.4 67.4979001159673 -0.271607305696778 0.30100311864626 -0.902340503707446 0.366876015723848 0.883373818299354 Probable conserved membrane protein VI - Unknowns Rv0011c - 299.2 170.6 148.7 195.9 325.7 260.6 104.885571354291 0.148494958484984 0.291072085592016 0.510165576966811 0.609935466159709 0.931582271037618 Probable conserved transmembrane protein VI - Unknowns Rv0012 - 80.1 70.7 46.3 57.5 64.5 61.1 81.0387277413117 -0.309777634393639 0.296465606630278 -1.04490243544494 0.296068064072242 0.837161771605085 Probable conserved membrane protein III.C - Cell division Rv0013 trpG 73.6 42.1 45.4 56.3 102.2 71.7 72.779519534222 0.294182186676149 0.329448709831607 0.892952917698527 0.371882386740444 0.885983360658111 Possible anthranilate synthase component II TrpG (glutamine amidotransferase) I.G.2 - Folic acid Rv0014c pknB 190.2 147.2 77.7 118.3 187.2 173.1 449.898406677606 0.06785625357312 0.253388256344527 0.267795574080817 0.788856677713074 0.963989543249515 Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0015c pknA 193.7 143.5 106 195 195.5 168.6 346.973241639953 0.150963614433334 0.19600770389735 0.770192249751544 0.441185860590514 0.901158530199572 Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0016c pbpA 243.9 162.2 132.3 177.5 224.9 182.4 445.420708487634 -0.0622611942787241 0.201354945142428 -0.309211150660759 0.757160912265764 0.959593750764785 Probable penicillin-binding protein PbpA II.C.3 - Murein sacculus and peptidoglycan Rv0017c rodA 139.7 78.3 61.5 97.2 116.5 124.6 231.33051698368 0.128613383731956 0.23666191309247 0.543447748103444 0.586821557915151 0.928941202821899 Probable cell division protein RodA II.C.3 - Murein sacculus and peptidoglycan Rv0018c pstP 232.2 158.3 113.4 209.6 185.9 149.4 430.256742331891 -0.058654198743467 0.183388273823492 -0.319836146120884 0.749092545053287 0.957707961696119 Phosphoserine/threonine phosphatase PstP I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0019c fhaB 429.3 312.1 185.9 370.8 370.9 311.5 245.277540743861 0.021831355821821 0.212092275174925 0.102933290728365 0.918015915842782 0.9932884147079 Conserved protein with FHA domain, FhaB V - Conserved hypotheticals Rv0020c fhaA 790.6 416.5 407.7 467.3 573.4 485 1333.40792964368 -0.236907635311762 0.188295990291594 -1.25816611891145 0.208331685318912 0.770341510876847 Conserved protein with FHA domain, FhaA V - Conserved hypotheticals Rv0021c - 22 11.4 1.7 13.3 22.5 17.4 20.4825559123244 0.495825165369604 0.576259947142851 0.860419274023729 0.389557965030353 NA hypothetical protein V - Conserved hypotheticals Rv0022c whiB5 3.4 4.1 0 6.9 0 0 1.19901267619054 0.299173014648451 1.99177972756905 0.150203865672229 0.880603776131908 NA Probable transcriptional regulatory protein WhiB-like WhiB5 V - Conserved hypotheticals Rv0023 - 99.9 64.4 39 72.5 76.4 64.3 84.4701080878009 -0.0840342617806389 0.279827900385344 -0.300306944607444 0.763943036538574 0.959593750764785 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0024 - 61.5 31.1 45.7 46.2 44.7 42.7 62.6037706389685 -0.282727601121588 0.329846982059722 -0.857147757897017 0.39136323020368 0.893826103932853 Putative secreted protein P60-related protein IV.A - Virulence Rv0025 - 113 86.4 46.9 107 67.8 78.9 47.5190919042958 -0.0991641735727484 0.351030162978644 -0.28249473700863 0.777564181577043 0.963013023606306 hypothetical protein V - Conserved hypotheticals Rv0026 - 55.8 29.5 25.5 47.9 43.1 34.3 83.2405461138885 0.0189481137233597 0.274114048947032 0.0691249273656205 0.944890179313855 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv0027 - 34.6 25.3 29.6 20.8 43.2 33.5 15.8088843550049 -0.161934192222087 0.581426249760225 -0.278512007823636 0.780619348641265 NA hypothetical protein V - Conserved hypotheticals Rv0028 - 22.4 16.6 9.3 14.8 3.1 10.8 5.17845243810465 -1.11256752535608 0.99199735491607 -1.12154283460787 0.262056869149807 NA hypothetical protein VI - Unknowns Rv0029 - 55.3 35.7 31.2 43 45.3 45 75.0856125056706 -0.072270285515595 0.292262930527424 -0.247278316771732 0.804692838520319 0.965592404376002 hypothetical protein V - Conserved hypotheticals Rv0030 - 63.8 48.2 44.2 66.7 74.4 39.4 29.2040904083003 0.0239058304951688 0.42162033951299 0.0566998985930855 0.954784254798376 0.998153412295216 hypothetical protein VI - Unknowns Rv0031 - 19.5 10.1 10.3 16.5 24.5 0 4.07368456999146 -0.171022971350937 1.03690971056016 -0.164935258691469 0.868994940014557 NA Possible remnant of a transposase V - Conserved hypotheticals Rv0032 bioF2 7.8 7.4 3.7 3 12.5 7.3 25.8504670565533 0.0838623708548375 0.535865496125652 0.156498918965988 0.875639771284893 NA Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) I.G.1 - Biotin Rv0033 acpA 3.9 0 1.7 7.1 6.2 9.4 1.34709491150871 1.6856675142384 1.83863995557741 0.916801306925275 0.359246767666805 NA Probable acyl carrier protein AcpA (ACP) I.H.1 - Synthesis of fatty and mycolic acids Rv0034 - 6.2 0 7.6 8 7.5 1 2.71852033300295 -0.125553187373219 1.31681933638093 -0.0953457956641813 0.924040168633417 NA hypothetical protein VI - Unknowns Rv0035 fadD34 8.4 5.3 3 6 8.7 5 15.502931095494 0.124623006338924 0.552573194507378 0.225532124210307 0.821565337515636 NA Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0036c - 81.3 47.7 40 95.5 66.9 47.7 75.9753221588864 0.159049103914626 0.296379432876579 0.536640152020464 0.591516203421458 0.928941202821899 hypothetical protein V - Conserved hypotheticals Rv0037c - 27.8 11.6 15.8 25.1 29.9 20.3 44.6245037231148 0.238260684750068 0.358847467011426 0.663960893285284 0.506715340903566 0.915911629458156 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0038 - 323.3 125 123.9 262.9 216.5 184.9 194.249646404321 0.0874766140488117 0.23783348364809 0.367806133547816 0.713017795230325 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv0039c - 61.6 20 16.7 76 22.1 19.3 17.5472318315582 0.144209565021919 0.613697617575543 0.234984723570591 0.814220590109407 NA Possible conserved transmembrane protein V - Conserved hypotheticals Rv0040c mtc28 161.6 84.8 56.4 108.7 160.5 110 165.231363579895 0.193543988344113 0.257249334973493 0.752359528408713 0.45183487808562 0.901158530199572 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) V - Conserved hypotheticals Rv0041 leuS 50.8 29.4 18.9 43.5 53.7 38.3 177.246555498636 0.306724402275162 0.234825333498939 1.30618105680896 0.191490993203973 0.741700010610815 Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv0042c - 169.4 113.5 86.8 142 159.1 110 129.703735728564 -0.0207371709997192 0.241583292515926 -0.0858385974615861 0.9315947233595 0.998010361628995 Possible transcriptional regulatory protein (probably MarR-family) V - Conserved hypotheticals Rv0043c - 78.6 51.9 42.1 52.4 76.8 65.5 72.0299598089527 -0.0347807772760795 0.310576743751839 -0.111987706664445 0.91083315391341 0.992834063067731 Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0044c - 43.2 20.3 11.5 27 50.4 27.7 36.3498187179951 0.352146061204607 0.420639733100394 0.837167850523908 0.402498225919339 0.893826103932853 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0045c - 42.4 26.2 17.1 48.6 33.7 41.8 48.9105619423929 0.405389035658847 0.342372763302406 1.18405749262473 0.236390305124252 0.78958848015113 Possible hydrolase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0046c ino1 192.2 197.3 89 166.2 204.4 139.3 292.395620586967 -0.092846616939492 0.250277557748994 -0.370974600258042 0.710656450051218 0.949890877982223 myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase) V - Conserved hypotheticals Rv0047c - 200.4 223.8 120 119.5 201.1 169.5 154.869577669238 -0.365757540203999 0.302926857603096 -1.20741205681811 0.227273494577872 0.780210909201606 hypothetical protein V - Conserved hypotheticals Rv0048c - 23.1 14.1 11.1 15 22.3 23.6 25.0414022314972 0.117357213598091 0.462409564589604 0.253794952754162 0.79965397292993 NA Possible membrane protein VI - Unknowns Rv0049 - 241.7 148.4 80.5 197.1 173.6 122.3 102.635107905837 -0.0626306691887037 0.272936403664603 -0.229469826478945 0.818503769952028 0.967203057682185 hypothetical protein VI - Unknowns Rv0050 ponA1 190.6 140 94.6 184.8 153.5 171.4 509.018259069926 0.0942321096501874 0.197494026797381 0.477139036447238 0.633263118941153 0.934189753061989 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) II.C.3 - Murein sacculus and peptidoglycan Rv0051 - 70.6 44.7 39.7 79.5 59 29 142.16724860225 -0.0680505924655285 0.273255618115235 -0.249036389205476 0.803332633428275 0.965592404376002 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0052 - 76.1 31.6 41.3 74.5 50.8 54.7 48.6356219473626 0.0853576447735837 0.349408552352279 0.244291801671543 0.807004832483736 0.965592404376002 hypothetical protein V - Conserved hypotheticals Rv0053 rpsF 75.8 29.8 29.2 89.1 94.1 70.1 28.6696343001536 0.734568925802502 0.423607166872373 1.73408049544123 0.0829038017194788 0.562041621739757 30S ribosomal protein S6 RpsF II.A.1 - Ribosomal protein synthesis and modification Rv0054 ssb 141.5 98.4 84.5 125.5 155.5 89 91.3965956063751 -0.0172448453164533 0.279019267924151 -0.0618052131121681 0.950717951963656 0.998153412295216 Single-strand binding protein Ssb (helix-destabilizing protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0055 rpsR1 145 99.8 62.9 92.5 128.6 87.9 41.1367829840845 -0.165124989656611 0.367202694610206 -0.449683491108078 0.652938676804167 0.939577115195416 30S ribosomal protein S18-1 RpsR1 II.A.1 - Ribosomal protein synthesis and modification Rv0056 rplI 164 101.5 58.2 169.2 138.1 139.9 91.7773338603559 0.323316282260882 0.27576427875061 1.17243713988524 0.241021595693515 0.78958848015113 50S ribosomal protein L9 RplI II.A.1 - Ribosomal protein synthesis and modification Rv0057 - 121 103.4 78.9 147.1 202.1 156.5 113.335582320956 0.534691920174831 0.279006702234156 1.91641245852973 0.0553126162655913 0.487244256658043 Hypothetical protein VI - Unknowns Rv0058 dnaB 150.7 93.3 71.1 172.7 157.4 125.2 530.740383485135 0.367129416443962 0.17452933914728 2.10353983025257 0.035418607359606 0.393445252838033 Probable replicative DNA helicase DnaB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0059 - 55.1 45 26.7 26.6 90.8 52.1 54.5214538253089 0.219615919836537 0.421428040459827 0.521123178222574 0.602280965421265 0.931398768888358 Hypothetical protein VI - Unknowns Rv0060 - 160.6 141.5 82.7 133.7 201.4 194.4 261.226194103439 0.290012472601827 0.263050884843255 1.1024957120925 0.270246221629541 0.812783093966197 hypothetical protein VI - Unknowns Rv0061c - 177.9 104.1 72.4 135.8 146 134.9 68.2627252715744 0.0461301038096235 0.29883199437723 0.154368021756704 0.877319566343286 0.980703859230131 Hypothetical protein ? Rv0062 celA1 27.3 11.7 13.9 21.8 18.5 10.7 30.8931705775403 -0.197758601364312 0.411346640382358 -0.480759004572129 0.6306877897556 0.93413540068838 Possible cellulase CelA1 (endoglucanase) (endo-1,4-beta-glucanase) (FI-cmcase) (carboxymethyl cellulase) II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv0063 - 37.6 26.4 21.5 36.4 33.8 30.9 71.4997813465533 0.0532766134644285 0.291360952755585 0.182854335697896 0.854912313539708 0.975712312098852 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0064 - 130.5 76.2 66.1 90.2 105 84.6 433.724718091325 -0.134821738742454 0.191693089618021 -0.703320808335387 0.48185584587994 0.907292899730371 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0064A vapB1 45.7 40 21.6 26.5 18.8 16.5 10.7268027906447 -0.938439837003784 0.665131767276041 -1.41090815861501 0.158271696200487 NA Possible antitoxin VapB1 ? Rv0065 vapC1 48.8 29 32.2 35.7 42 30.3 23.4886055628114 -0.247711925678263 0.458419183930431 -0.540361168034921 0.588947982243851 NA Possible toxin VapC1 V - Conserved hypotheticals Rv0066c icd2 110.1 67.5 65.5 71.2 81.7 60.1 275.489806968128 -0.387226097710284 0.209957879552016 -1.84430371718605 0.0651388900818746 0.514454587842348 Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) I.B.3 - TCA cycle Rv0067c - 42.6 36.6 18.6 18.8 20.2 25.2 24.7294054970062 -0.851145982310092 0.469066655504979 -1.8145523079098 0.0695927373129249 NA Possible transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0068 - 9.1 7.6 7 7.2 4.1 0 8.18749377453082 -1.07031348522124 0.796773331867578 -1.34330987548554 0.179171655697927 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0069c sdaA 51.4 38.4 25.4 30.3 40.4 35.4 82.0092587667563 -0.324174768907068 0.295260857954294 -1.09792666441838 0.272236513502534 0.813286748879977 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) I.C.2 - Gluconeogenesis Rv0070c glyA2 21.5 5.9 8.6 14.3 15.1 20.7 28.3639923219677 0.255811949547587 0.456659687361723 0.560180713619587 0.575356180697795 0.926330148899942 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) I.D.3 - Serine family Rv0071 - 21 14.6 14.8 34.1 36.5 38 29.5150152173326 0.880245481590607 0.422983046767056 2.08104199049701 0.0374300627713107 0.399823674443666 Possible maturase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0072 - 174.4 125.7 79.6 171 135.8 160.7 236.475677634386 0.144693675340768 0.223411696600368 0.647654879053141 0.517208193840933 0.915911629458156 Probable glutamine-transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv0073 - 215.8 180.4 117.6 279.2 192.2 174.5 306.786535742512 0.144860043560907 0.219167562086451 0.6609556732842 0.508640740877123 0.915911629458156 Probable glutamine-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv0074 - 112.3 80.1 64.8 128.6 95 86.7 186.819277999421 0.0900995263170601 0.225954083726245 0.398751484510544 0.690076328149993 0.942913432418385 hypothetical protein V - Conserved hypotheticals Rv0075 - 91.6 74.1 39 110.6 120.6 114.9 170.630517086376 0.599913888967982 0.246221362980127 2.43648187836732 0.0148309125531699 0.266378598195246 Probable aminotransferase IV.H - Miscellaneous transferases Rv0076c - 8.9 0 11.5 12.6 16 7.3 5.38344631710329 0.279529032295298 0.967072982793838 0.289046470399524 0.772545816291384 NA Probable membrane protein II.C.5 - Other membrane proteins Rv0077c - 8.5 8.3 7.6 3.8 4.4 3.3 7.70318159573797 -1.43348753807572 0.805851181735052 -1.77884896190053 0.0752645275373557 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0078 - 6.2 2.8 1.4 5.3 0 4.7 2.488158959219 -0.203628347718525 1.3551503875107 -0.150262546205351 0.880557481237752 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0078A - 409.6 267.5 208.4 278.9 216.5 181.4 248.907777701609 -0.554247365251027 0.20734407314786 -2.67308033857223 0.00751582486685976 0.173743285221869 Hypothetical protein ? Rv0078B - 1015.4 608.1 528.9 925.5 695.3 834.9 254.477271270309 0.0180682023818625 0.216049728689458 0.0836298313886477 0.933350747993442 0.998010361628995 hypothetical protein ? Rv0079 - 1501.7 628.8 793.9 808.4 30.7 345.7 912.039252894961 -1.49088238352698 1.06782701482289 -1.39618342936777 0.16265926537034 0.719864844822977 hypothetical protein VI - Unknowns Rv0080 - 1085.4 375.9 604.6 622.3 25 227 362.869238188799 -1.44116011229733 1.06919851453191 -1.34788824779491 0.177694328538014 0.734764437650925 hypothetical protein VI - Unknowns Rv0081 - 353 154.8 158.7 184.1 25.6 57.9 84.9663383257424 -1.48726265883762 0.722349945124682 -2.05892264390068 0.0395016495008954 0.407692397460734 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0082 - 423.9 212.3 205.8 262.4 55 146.4 167.580640384838 -1.02316349639684 0.589714812447463 -1.73501406917431 0.0827383132488527 0.562041621739757 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0083 - 123.2 51.4 60.7 88.1 21.4 49.2 200.99377811629 -0.716049274507535 0.342820863852824 -2.08869806364802 0.0367349112807254 0.398982485820102 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0084 hycD 208.9 105.1 107.1 181.8 47.5 61.8 178.770452991043 -0.707751781998481 0.345420284864699 -2.04895836466497 0.0404661863775904 0.409898801332397 Possible formate hydrogenlyase HycD (FHL) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0085 hycP 150.4 64.7 59.1 141.4 45 28.2 82.3573564512986 -0.463767700396959 0.398347660315096 -1.16422850338851 0.244331421999165 0.78958848015113 Possible hydrogenase HycP I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0086 hycQ 139.6 84.3 69.3 109 45.5 52.7 195.422587784184 -0.6580954909971 0.274867512687219 -2.39422798483271 0.0166553924723096 0.276757764055105 Possible hydrogenase HycQ I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0087 hycE 111.6 79.4 53.8 70.8 33.3 50.8 159.656712978583 -0.815464294167232 0.270705992339117 -3.01236144468383 0.00259223742638399 0.0885201076713349 Possible formate hydrogenase HycE (FHL) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0088 - 312.6 240 184.7 209 150 132.7 226.021851942053 -0.775793182582959 0.22505648228927 -3.44710436549797 0.000566629646299535 0.0307313255228336 Possible polyketide cyclase/dehydrase VI - Unknowns Rv0089 - 44.6 40.5 20.7 26.1 18.1 27.1 28.2225811416768 -0.790013549805018 0.443126767781111 -1.78281613128652 0.0746162389746 0.54162997700187 Possible methyltransferase/methylase I.G.1 - Biotin Rv0090 - 7.1 6.7 3.2 4.5 0.6 0.9 4.25489085797067 -1.63074786385746 1.15998216851004 -1.40583873453168 0.159772017126814 NA Possible membrane protein VI - Unknowns Rv0091 mtn 5.6 8.5 4.2 6.9 4.8 3.7 6.64290161849764 -0.469119649881095 0.843958751186626 -0.555856135411241 0.578309206797964 NA Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase) V - Conserved hypotheticals Rv0092 ctpA 28.8 11.6 9.8 24.6 26.5 12.2 65.2239466874342 0.20816718102865 0.329949497432026 0.630906192156074 0.52810186284569 0.922751607774049 Cation transporter P-type ATPase a CtpA III.A.2 - Cations Rv0093c - 32.3 24.4 16.8 38.3 15.8 11.6 30.8260576012087 -0.288731005113492 0.456050985192975 -0.633111240821719 0.526661002213837 0.921428654655606 Probable conserved membrane protein VI - Unknowns Rv0094c - 10.5 8.9 9.1 7.3 9.7 7.8 13.7478800474923 -0.473363057583469 0.595891340425616 -0.79437814492382 0.426975323417599 NA hypothetical protein IV.B.2 - REP13E12 family Rv0095c - 19.9 4.2 15.7 21.9 25.1 0 8.9512153824402 0.0753599609687625 0.800694466190885 0.094118248783796 0.925015224294652 NA hypothetical protein IV.B.2 - REP13E12 family Rv0096 PPE1 3.9 3.8 1.9 1.6 3.2 4.2 6.80659174249968 -0.479903394249878 0.848489892862978 -0.565597066372335 0.571667722544354 NA PPE family protein PPE1 IV.C.2 - PPE family Rv0097 - 19.7 12.3 15.7 10 20.6 9.7 20.9128050288753 -0.500986636491378 0.516368562127052 -0.970211343672217 0.331941157550596 NA Possible oxidoreductase V - Conserved hypotheticals Rv0098 fcoT 20 16.4 5.8 10.4 47.7 25.1 17.6038236923621 0.818182946818395 0.61912582886507 1.32151318629077 0.186330308716115 NA Probable fatty acyl CoA thioesterase type III FcoT VI - Unknowns Rv0099 fadD10 22 18.3 10.7 22.6 21.3 19.7 48.7184755456583 0.161820991279317 0.338774960045801 0.477665147558248 0.632888554190175 0.93413540068838 Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0100 - 24.3 42.4 8.1 16.2 31.9 22 8.86077553232439 -0.312438752353343 0.76963690670597 -0.405956041908871 0.68477489941363 NA hypothetical protein VI - Unknowns Rv0101 nrp 19 14.6 8.8 18.8 18.1 15.8 190.445314356045 0.152525055500368 0.223716970448604 0.681776868310527 0.495380053120044 0.913636152872564 Probable peptide synthetase Nrp (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv0102 - 84 48.7 40 72.1 59.7 47.7 184.100570318033 -0.108110404299135 0.218067283318108 -0.495766272932503 0.620059323054383 0.931582271037618 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0103c ctpB 55.2 29 27.3 52.5 45.8 26.9 139.397115738805 0.00445492631767714 0.247783696322766 0.0179790937974955 0.985655531448931 0.999019127881181 Probable cation-transporter P-type ATPase B CtpB III.A.2 - Cations Rv0104 - 4.5 8 3.5 2.2 2.3 1.9 9.14766042728543 -1.62224047627682 0.784270214812185 -2.06847135800677 0.0385957212153928 NA hypothetical protein VI - Unknowns Rv0105c rpmB1 0.6 0 0 0 0 0 0.0224003920381287 -0.0353864558230091 4.03001480255116 -0.00878072601634317 0.992994084306394 NA 50S ribosomal protein L28-1 RpmB1 II.A.1 - Ribosomal protein synthesis and modification Rv0106 - 5.5 1 3.6 4.4 9.3 8 9.49892149148263 0.802204046467583 0.734980815901969 1.09146256488765 0.275069395484966 NA hypothetical protein V - Conserved hypotheticals Rv0107c ctpI 39.7 28.7 21.7 51.6 39.7 30.4 273.786559589095 0.252238164850143 0.210336487338889 1.19921259521532 0.230445290990826 0.784923331661854 Probable cation-transporter ATPase I CtpI III.A.2 - Cations Rv0108c - 720.4 485.1 264.5 665.9 832.3 621.8 196.609977150662 0.384042786875738 0.236739885800731 1.62221412575571 0.104757508161476 0.637015195243683 Hypothetical protein VI - Unknowns Rv0109 PE_PGRS1 8.4 3.4 4.3 7.3 7.2 1.8 11.6857025640854 -0.172577918388021 0.650337950867748 -0.265366519296236 0.790727125566299 NA PE-PGRS family protein PE_PGRS1 IV.C.1.b - PE_PGRS subfamily Rv0110 - 29.2 19.7 10.2 32.7 8.7 33.1 25.6684307561421 0.191037485353841 0.510149025180223 0.374473881012223 0.708051785288935 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0111 - 10.7 8.8 6.7 20.7 27 17.7 49.0042035946325 1.15654015598074 0.350726347648715 3.29755709468148 0.000975298437082552 0.0481727763744704 Possible transmembrane acyltransferase IV.H - Miscellaneous transferases Rv0112 gca 29.3 30.8 11.3 29.5 36.3 58.8 50.3384887179821 0.674445261730953 0.413124354964637 1.63254781187782 0.102564134970329 0.633241958321271 Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0113 gmhA 26.6 33.2 8.3 29 47 29.4 26.8066957543635 0.501523083576795 0.487227883090511 1.02933986535337 0.303319996304756 NA Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0114 gmhB 48 30.2 29.3 65.5 35.6 34.7 36.2860279539397 0.179712611647023 0.395705035040821 0.454158010975229 0.649715102247479 0.939577115195416 Possible D-alpha,beta-D-heptose-1,7-biphosphate phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate kinase) I.D.5 - Histidine Rv0115 hddA 24.7 30.3 8.7 26.7 29.5 7.3 38.3846172896666 -0.138241812175978 0.451440073868069 -0.306224059799305 0.759434054699505 0.959593750764785 Possible D-alpha-D-heptose-7-phosphate kinase HddA V - Conserved hypotheticals Rv0116c ldtA 46.6 26.6 18.4 24.8 47.4 44.7 41.0652816268539 0.145426022298455 0.403731390148944 0.360204893270261 0.718693915682515 0.949890877982223 Probable L,D-transpeptidase LdtA V - Conserved hypotheticals Rv0117 oxyS 15.9 7.3 4.2 16 22.1 9.3 17.1826406983768 0.647723071652076 0.54161022338615 1.19592105851051 0.231727366466574 NA Oxidative stress response regulatory protein OxyS I.J.1 - Repressors/activators Rv0118c oxcA 49.2 18.7 33 24.7 26.5 23.3 83.0934131896733 -0.660745600166222 0.319510061850485 -2.06799622002333 0.038640378544004 0.403318064349868 Probable oxalyl-CoA decarboxylase OxcA I.A.1 - Carbon compounds Rv0119 fadD7 10.2 11.4 5.4 9.5 7.1 14.6 24.8475923510374 0.00347810702794002 0.485027850389944 0.00717094291625472 0.994278464396634 NA Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0120c fusA2 38 23.2 22 22.1 16.6 16.5 80.3006618892233 -0.785487957613671 0.286795310234101 -2.7388451958036 0.00616553969547631 0.155035298160795 Probable elongation factor G FusA2 (EF-G) II.A.6 - Protein translation and modification Rv0121c - 45.7 25 22.2 25.9 18.2 11.8 17.0596781300633 -0.826739766056191 0.534566313864395 -1.54656166057241 0.121968980730947 NA hypothetical protein VI - Unknowns Rv0122 - 10.9 13.7 0 13.1 17.4 0 4.50425628812645 0.325843711560826 1.07892883357368 0.302006676827378 0.762646973099619 NA Hypothetical protein VI - Unknowns Rv0123 - 6.3 0.4 2.9 14 2.8 7.7 2.33050325022942 1.05197315373146 1.46988954650903 0.715681770939785 0.474187869265907 NA hypothetical protein VI - Unknowns Rv0124 PE_PGRS2 2.6 0 3.7 2.4 0 1.9 4.07565598502333 -1.03761798800019 1.20323685152084 -0.862355559247281 0.388491887801447 NA PE-PGRS family protein PE_PGRS2 IV.C.1.b - PE_PGRS subfamily Rv0125 pepA 85 43 34.1 69.8 69.3 53.1 98.0946177393099 0.0916065823839195 0.263403566475824 0.347780341813738 0.728005154131167 0.949890877982223 Probable serine protease PepA (serine proteinase) (MTB32A) II.B.3 - Proteins, peptides and glycopeptides Rv0126 treS 63.8 58.2 30.6 62.8 79.2 62.2 171.81659073065 0.252172460596242 0.253985513332733 0.992861589967471 0.320777410330498 0.849868688356633 Trehalose synthase TreS II.A.8 - Polysaccharides (cytoplasmic) Rv0127 mak 89.9 41.2 40.6 70.2 78.6 71.3 140.840079728098 0.194685339175876 0.247986039628253 0.785065721714503 0.432415036184132 0.901158530199572 Maltokinase Mak V - Conserved hypotheticals Rv0128 - 15.5 23.8 13.1 13.2 13.3 10.3 18.7005693056721 -0.713031022735758 0.546101255562856 -1.30567548686708 0.191662937526805 NA Probable conserved transmembrane protein VI - Unknowns Rv0129c fbpC 220.1 134.6 125.7 149.1 245.6 206.7 297.819725493098 0.142662344500078 0.24873609424175 0.573549025665018 0.566273014451867 0.92521033104044 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0130 htdZ 7.7 6 2.4 12 3.9 6.1 3.56684314818505 0.396149196324218 1.11759305022543 0.35446640997303 0.722989372920565 NA Probable 3-hydroxyl-thioester dehydratase V - Conserved hypotheticals Rv0131c fadE1 19.3 12.8 5.4 12 15.1 19 29.2486660423319 0.145729815934965 0.450136217519493 0.323746035673422 0.74613031479749 0.956095160416489 Probable acyl-CoA dehydrogenase FadE1 I.A.3 - Fatty acids Rv0132c fgd2 9.1 3.2 6.3 6.2 1.7 2.5 7.77907748679057 -1.05691568364843 0.831589081329857 -1.27095906785866 0.203743210836213 NA Putative F420-dependent glucose-6-phosphate dehydrogenase Fgd2 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0133 - 104.1 70.1 34.9 118.5 94.4 33.8 70.19634333807 0.125893968909046 0.346999322959168 0.362807534710551 0.716748662968902 0.949890877982223 GCN5-related N-acetyltransferase IV.D - Antibiotic production and resistance Rv0134 ephF 191.8 130.4 91.2 193.9 122.6 101.6 197.840075342262 -0.137718732389015 0.236782265607715 -0.581626043806753 0.560818596474455 0.92521033104044 Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv0135c - 97.6 61 41.2 67 70.5 74.8 65.5777880996396 -0.0894104938966071 0.307814254814938 -0.290468984129282 0.771457475487022 0.962399953173527 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0136 cyp138 21.3 5.2 17 13.6 10.7 9.1 27.4206897924886 -0.626173771613517 0.492657132526517 -1.27101330777915 0.203723914352653 0.764223090185471 Probable cytochrome P450 138 Cyp138 IV.F - Cytochrome P450 enzymes Rv0137c msrA 98.1 85 64.5 72.8 108.9 98.1 78.7287940529285 -0.0652619923271285 0.318712409816947 -0.204767653586542 0.837753660188639 0.971991033591349 Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0138 - 77.3 57.9 47.9 55.5 87.1 30.1 47.3630395090367 -0.30536784836368 0.371924915795614 -0.821047032330286 0.411619478874558 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0139 - 80.1 44 29.4 81.3 80.2 47.2 94.9719011690536 0.312698058310476 0.274957093182835 1.13726128935523 0.255429072233904 0.800346416224053 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0140 - 85 55.1 61.5 50.6 117.2 158.6 55.13771665418 0.46926386528653 0.431160220979524 1.08837467477969 0.276429736572302 0.818634530362941 hypothetical protein V - Conserved hypotheticals Rv0141c - 232.1 167.7 77.2 173.2 225.5 177.5 112.897657582354 0.126184051223744 0.280517347371408 0.449826195799133 0.652835767677383 0.939577115195416 hypothetical protein VI - Unknowns Rv0142 - 27.3 13 7.4 19.7 10.4 12.1 20.51330818954 -0.280884256584139 0.511012014681166 -0.549662725169761 0.582550727690837 NA hypothetical protein VI - Unknowns Rv0143c - 71.7 42.1 24.7 64.5 52.3 55.9 119.514082801699 0.183487949962584 0.259968481552709 0.705808445957254 0.480307268988726 0.907292899730371 Probable conserved transmembrane protein III.A.4 - Anions Rv0144 - 757 611.3 410.2 539.2 635.4 467.9 780.091064494667 -0.307211602950453 0.192041198884554 -1.5997171686849 0.109661341368233 0.645368660052197 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0145 - 771.9 517.1 362.9 685.9 580.2 467.9 856.414267108648 -0.0989032992230997 0.170583950478393 -0.579792524125108 0.562054539622454 0.92521033104044 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0146 - 171.1 109.7 87.6 155.6 90.7 120.8 183.367639032457 -0.168690579072004 0.242981621945307 -0.694252420086219 0.487523923833243 0.909299509995111 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0147 - 197.5 131.7 95.1 189.1 167.7 136.3 369.476661280832 0.0530736428328719 0.186858679995533 0.284030920234161 0.77638668509772 0.963013023606306 Probable aldehyde dehydrogenase (NAD+) dependent I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0148 - 267.2 164.1 198.3 184 255.7 197.7 298.706014878079 -0.20925471993335 0.244810046445893 -0.85476361354965 0.392682025692896 0.893826103932853 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0149 - 148.2 67.2 56 124.3 98 69.2 140.455880363325 -0.030242078342116 0.251848052191815 -0.120080652119091 0.904419258851247 0.991208909356546 Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0150c - 1.2 0 0 8.3 10.5 2.4 1.12319894336221 2.68481080831889 2.01787915038817 1.3305111992472 0.183349898915188 NA hypothetical protein V - Conserved hypotheticals Rv0151c PE1 25.1 16.3 16.3 15.1 24.6 33.9 63.2688419128161 0.141461532241034 0.377484484560876 0.374747938065837 0.707847936540935 0.949890877982223 PE family protein PE1 IV.C.1.a - PE subfamily Rv0152c PE2 18.8 9.8 9.8 10.8 20.5 6.5 31.6577536834031 -0.227240558878471 0.43151729075584 -0.526608235049955 0.598465672082445 0.930022694368295 PE family protein PE2 IV.C.1.a - PE subfamily Rv0153c ptbB 75.9 59.5 53.1 62 65.6 46.4 81.5614905317504 -0.322867173504821 0.291424033266343 -1.10789480842076 0.267907247966456 0.810756507522119 Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0154c fadE2 106.6 64 65.1 76.7 103 110.3 172.470066734406 0.0979333538755569 0.265457583721109 0.368922795509381 0.712185271658711 0.949890877982223 Probable acyl-CoA dehydrogenase FadE2 I.A.3 - Fatty acids Rv0155 pntAa 24.5 17.3 11.3 37.4 24.9 26.1 39.9202361900896 0.575455220999769 0.367589998696952 1.56548116934538 0.117470129324089 0.656813446599338 Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha) I.C.1 - General Rv0156 pntAb 78.6 44.1 23 79.1 119.8 52.6 33.2397162381305 0.662225428672003 0.421615032021106 1.57068742425401 0.116255271705205 0.653581466537801 Probable NAD(P) transhydrogenase (subunit alpha) PntAb [second part; integral membrane protein] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha) I.C.1 - General Rv0157 pntB 100 77.9 38.9 140.5 110.8 74.9 200.482938812394 0.438330881753041 0.243908708998398 1.79711041706149 0.0723180922859286 0.54162997700187 Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta) I.C.1 - General Rv0157A - 119.7 101 47.5 113.7 58.2 81.5 17.2852553375543 -0.194048922383495 0.538097289822756 -0.360620516128994 0.71838315029649 NA hypothetical protein ? Rv0158 - 64 30.1 25.8 52.7 56 38.6 43.8303129869539 0.138448214251631 0.352862193284863 0.392357744429318 0.6947939030888 0.943825877173016 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0159c PE3 3.2 1.2 1.5 1.4 1.5 0 2.87610602023045 -1.00571455727393 1.24981468739445 -0.804690941319143 0.420998048297765 NA PE family protein PE3 IV.C.1.a - PE subfamily Rv0160c PE4 2 1.1 3.6 0.4 0 0 3.0786377849753 -3.78984776353902 1.51908407683714 -2.49482423081532 0.012601953684245 NA PE family protein PE4 IV.C.1.a - PE subfamily Rv0161 - 9.2 2.7 5.7 10.1 6.2 2.9 12.489872870144 -0.0442739460501471 0.643392923897374 -0.0688132312397161 0.945138286048237 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0162c adhE1 14.2 7.5 3.7 11.1 15.7 5.5 16.0763046453208 0.198950612006417 0.565090887690379 0.352068342173347 0.724787009602571 NA Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0163 - 26 16.9 7.1 25.4 19.9 21.4 13.1573342340895 0.241165812025708 0.590851622748025 0.408166454555978 0.683151474171992 NA hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0164 TB18.5 122.4 98.7 75.8 73.1 118 110.6 79.1809410260438 -0.211836936922505 0.323230135770496 -0.655374958827837 0.512226369931653 0.915911629458156 Conserved protein TB18.5 V - Conserved hypotheticals Rv0165c mce1R 75.6 58.8 38.3 44.7 41.8 25.3 51.5151580891848 -0.779624890960131 0.338035165525283 -2.30634256571694 0.0210914984823599 0.299174793857474 Probable transcriptional regulatory protein Mce1R (probably GntR-family) I.J.1 - Repressors/activators Rv0166 fadD5 171.9 142.6 85.6 163 221 170.4 424.404655718879 0.297452525026317 0.22089258308485 1.346593538236 0.178111176419448 0.734764437650925 Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0167 yrbE1A 183.8 148.4 61 201.1 231.2 143.4 200.674494777603 0.413611495333761 0.256936850362432 1.60977880265258 0.107446154384829 0.643080319504058 Conserved integral membrane protein YrbE1A IV.A - Virulence Rv0168 yrbE1B 90.7 59.4 37.7 97.5 109.6 68.9 104.568979789544 0.414475235904009 0.261792976595681 1.5832175534034 0.113371886929039 0.649247700301701 Conserved integral membrane protein YrbE1B IV.A - Virulence Rv0169 mce1A 209.9 181.4 113.2 197.9 231.4 214.2 422.431292333903 0.168915421242456 0.218268268518355 0.773889042090655 0.438996410206505 0.901158530199572 Mce-family protein Mce1A IV.A - Virulence Rv0170 mce1B 226.1 187.1 133.8 191.5 253.8 221.9 342.451560953823 0.0929136923517918 0.228334645991964 0.406918941048753 0.684067523965586 0.942913432418385 Mce-family protein Mce1B IV.A - Virulence Rv0171 mce1C 294.2 258.8 165 210.6 308.1 242.2 621.571275073447 -0.109586989350655 0.226319486383191 -0.484213671133507 0.628234235533293 0.93413540068838 Mce-family protein Mce1C IV.A - Virulence Rv0172 mce1D 279.2 179.4 142.6 169.4 243 217.2 527.958186563368 -0.097005076036992 0.219254337399357 -0.442431731055353 0.658176821663944 0.939577115195416 Mce-family protein Mce1D IV.A - Virulence Rv0173 lprK 276.1 198.8 172.7 207 242.8 183.2 407.455222063602 -0.238533112442552 0.20238048200146 -1.17863694207839 0.238542774854861 0.78958848015113 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) II.C.1 - Lipoproteins(lppA-lpr0) Rv0174 mce1F 698.2 418.5 319.9 480.9 536 438.4 1190.32386549557 -0.132872046479941 0.169951937257113 -0.781821311509529 0.434319594610875 0.901158530199572 Mce-family protein Mce1F IV.A - Virulence Rv0175 - 682.5 404.6 292.4 620.5 472.4 444.7 492.91956521387 0.0103510616079073 0.186156412720647 0.0556041097732178 0.95565719044685 0.998153412295216 Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv0176 - 286.2 226.9 163 289.2 228 196.5 361.826502732972 -0.112711461066655 0.201833272175487 -0.558438456909407 0.576545018492906 0.926626101773025 Probable conserved Mce associated transmembrane protein V - Conserved hypotheticals Rv0177 - 542.1 390.2 320.8 451.6 550.9 455.6 405.434242878904 0.0220891958555811 0.205174930893486 0.107660306058777 0.91426515761455 0.9932884147079 Probable conserved Mce associated protein V - Conserved hypotheticals Rv0178 - 463 306.9 352.9 431.7 407.1 405.4 476.213002565947 -0.0811713404296026 0.219922652334095 -0.369090403230911 0.712060341859988 0.949890877982223 Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv0179c lprO 156.7 82 45.5 157.7 170.7 141.9 214.708372813073 0.621390745643696 0.240486464728472 2.58389072476614 0.00976927413715645 0.202977384797616 Possible lipoprotein LprO II.C.1 - Lipoproteins(lppA-lpr0) Rv0180c - 51.3 42.8 14.6 40.6 50 26.4 79.4894251140028 -0.0124610785120702 0.330164899794043 -0.0377419844442685 0.969893401082035 0.998153412295216 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0181c - 124.2 83.6 64.4 72.8 109.8 86.5 106.611581538075 -0.218058613289465 0.278672871834582 -0.78248956152037 0.433926917588511 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0182c sigG 96.9 71.3 54.6 101.1 99.4 53.2 139.887099007654 0.000943992860043964 0.250500491648851 0.00376842717485458 0.996993237255203 0.999833281786427 Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0183 - 109.6 83.9 43.8 108.8 115.6 75.9 118.105825349194 0.18545522021224 0.259992867825614 0.713308875598197 0.475654646478545 0.90542768727261 Possible lysophospholipase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0184 - 127.7 90.2 53.7 107.9 152.2 73.5 118.471700353298 0.138114091148784 0.274292532252371 0.503528441021164 0.61459278941835 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv0185 - 97.9 83.3 58.1 121.2 128.6 115.8 82.3120257075263 0.417273662527758 0.288507832804663 1.44631658167242 0.148088426999376 0.695223866622759 hypothetical protein V - Conserved hypotheticals Rv0186 bglS 79.1 54.7 33.5 99.7 80.1 62.3 221.695532059457 0.3866310201922 0.217094321643729 1.78093566549702 0.074922961310406 0.54162997700187 Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase) I.A.1 - Carbon compounds Rv0186A mymT 174.2 132.7 62 145.2 221.7 227.8 40.5221750269988 0.523064446225898 0.398483977008149 1.31263608176446 0.189305605224822 0.739746500217031 Metallothionein, MymT ? Rv0187 - 52.1 44.5 34.7 65.5 68.8 47.7 55.0062562206337 0.289351232913485 0.32922740270445 0.878879554182302 0.379466585570672 0.893490749801147 Probable O-methyltransferase IV.H - Miscellaneous transferases Rv0188 - 138.6 56.7 78.5 103.5 65.4 38.6 54.1769515376013 -0.558528374111999 0.366362548075335 -1.52452366391214 0.127377950132071 0.671582561030228 Probable conserved transmembrane protein IV.H - Miscellaneous transferases Rv0189c ilvD 190.4 101.3 74 171.6 150.6 129 367.883702820124 0.16937164952573 0.193595710652842 0.874872945038797 0.381643041422308 0.893490749801147 Probable dihydroxy-acid dehydratase IlvD (dad) I.D.7 - Branched amino acid family Rv0190 - 362 279.9 166.6 373.6 431.6 302.4 146.63831718037 0.288090822522017 0.242201273855695 1.18946865115856 0.23425529995498 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv0191 - 57.6 29.5 30.2 55.1 42.2 28.5 78.8577434384224 -0.0642293355529256 0.292866778487891 -0.219312466523346 0.826406651399539 0.967727711626973 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0192 - 151.3 114.8 69.3 137 151.8 150.2 227.184845008355 0.224986847233547 0.229948164049948 0.978424194701015 0.327864566659205 0.853347384539607 hypothetical protein V - Conserved hypotheticals Rv0192A - 117.3 69.3 48.5 116.1 78.4 55.9 37.9276756382561 -0.00933497266109676 0.379837843564779 -0.0245762048707102 0.980392999328616 0.998567088804884 Conserved secreted protein ? Rv0193c - 8.5 5.6 5.9 6.9 6.8 7.7 20.6727003658562 -0.170727539069786 0.488183618384002 -0.34971992635667 0.726548897810533 NA Hypothetical protein VI - Unknowns Rv0194 - 2.1 0.9 1.5 1.6 1 3.9 10.5886136130458 0.202183878578407 0.721517391311921 0.280220381397571 0.779308430724776 NA Probable transmembrane multidrug efflux pump II.C.5 - Other membrane proteins Rv0195 - 2.7 0 0 0.9 2.9 0 0.678048162909956 -0.148363373497529 2.49732067293795 -0.0594090198768858 0.952626328927819 NA Possible two component transcriptional regulatory protein (probably LuxR-family) I.J.1 - Repressors/activators Rv0196 - 16.8 14.1 9.2 13.1 13.9 18.6 13.2918356652541 -0.0634589265023003 0.596828451113822 -0.106326912505379 0.915322979526829 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0197 - 22.4 11.7 6.5 20.1 19 6.8 49.6701011431435 0.0824502454728778 0.372514020751534 0.221334609920285 0.824831903349972 0.967727711626973 Possible oxidoreductase V - Conserved hypotheticals Rv0198c zmp1 131.6 78.6 65.8 88.6 105.1 100 303.751697994771 -0.0790839348533456 0.213802375061653 -0.36989268632091 0.711462451047779 0.949890877982223 Probable zinc metalloprotease Zmp1 II.B.3 - Proteins, peptides and glycopeptides Rv0199 - 44.9 21.8 26.2 45.6 37.8 57.6 40.6311366217454 0.406300786862494 0.383173704478166 1.06035665316811 0.288982374467807 0.83054472942914 Probable conserved membrane protein V - Conserved hypotheticals Rv0200 - 101 63.8 53.8 98.4 84.4 81.8 88.3286013762209 0.102900486429392 0.269325851502912 0.382066874959008 0.702411761279757 0.947279830180307 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0201c - 122.5 88.5 39.7 101.2 105.5 51.2 66.3656654043023 -0.0803437325764953 0.325553247532885 -0.246791371873443 0.805069688246017 0.965592404376002 hypothetical protein V - Conserved hypotheticals Rv0202c mmpL11 151.9 87.4 64.5 115.3 109.9 77.2 461.790654529748 -0.158276434421525 0.184405264836134 -0.858307568182353 0.390722651505201 0.893826103932853 Probable conserved transmembrane transport protein MmpL11 II.C.4 - Conserved membrane proteins Rv0203 - 67.6 49.9 35.1 73 65.8 58.4 37.7282333564051 0.219686642190193 0.368415053610347 0.596302024136461 0.550973479087241 0.92521033104044 Possible exported protein VI - Unknowns Rv0204c - 39.9 16.7 21.9 38.4 31.7 13.7 52.3766614110989 -0.0674488495306615 0.356426471981314 -0.189236363830455 0.849907568307205 0.975474031954732 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0205 - 24.7 19.8 9.5 34.4 40.3 25.7 43.8010762326256 0.747495368563964 0.360536338058286 2.07328718261714 0.0381455608362757 0.401181069479615 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0206c mmpL3 310.1 203.1 157.8 275.4 308.1 259.6 1144.1746629138 0.162004868255221 0.173265505585558 0.935009352887171 0.349783479412318 0.865921346048147 Possible conserved transmembrane transport protein MmpL3 II.C.4 - Conserved membrane proteins Rv0207c - 173.4 103.4 77.7 136.9 129.4 71 132.012902069312 -0.221236822978182 0.248953694272378 -0.888666559557571 0.374182308140125 0.887356086865747 hypothetical protein V - Conserved hypotheticals Rv0208c - 85.1 51.7 38.6 46.4 53.9 28.2 63.4092063935067 -0.607623500075724 0.310209034610194 -1.95875500801986 0.0501414849614605 0.456221537511184 Hypothetical methlytransferase (methylase) V - Conserved hypotheticals Rv0209 - 16.8 11.2 4 19.9 6.6 2.6 15.7600492588959 -0.159406257265352 0.6508200985977 -0.244931368297967 0.806509572909088 NA Hypothetical protein VI - Unknowns Rv0210 - 18.4 8.2 5.4 20.4 9 9.7 26.0792570509502 0.211949016360402 0.470815297383626 0.450174447470646 0.652584659480134 NA Hypothetical protein VI - Unknowns Rv0211 pckA 480.4 279.4 231.7 374.4 317.8 259.4 939.324547294175 -0.223033871650902 0.165376245532479 -1.34864515113871 0.177450970763779 0.734764437650925 Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase) I.C.2 - Gluconeogenesis Rv0212c nadR 25 10.3 8.8 15.4 15.6 6 19.5006389425693 -0.386960840054332 0.51251413451528 -0.755024718333489 0.450234151035264 NA Possible transcriptional regulatory protein NadR (probably AsnC-family) I.J.1 - Repressors/activators Rv0213c - 7.5 5 4.3 5.6 11 10.3 15.1649542579857 0.50303173964651 0.583515339399643 0.862071149944507 0.388648366066618 NA Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0214 fadD4 6.6 3.2 2 5.4 5.3 6.4 11.8838339992653 0.306650970007499 0.623788603515118 0.491594377132713 0.623006119200445 NA Probable fatty-acid-CoA ligase FadD4 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0215c fadE3 28.4 17.3 22.5 23.6 23.9 10.2 36.486889943238 -0.450568792338113 0.404856203984367 -1.11291067767733 0.265746793710157 0.80816433845196 Probable acyl-CoA dehydrogenase FadE3 I.A.3 - Fatty acids Rv0216 - 15.5 15.3 1.1 21.3 8.6 8.4 17.5949755065267 0.231578676777854 0.653513815361255 0.354359267293897 0.723069656556446 NA Double hotdog hydratase V - Conserved hypotheticals Rv0217c lipW 18 6.9 5.9 5 11.9 3.1 11.1602645008444 -0.94740503367079 0.684291100228913 -1.38450585336249 0.166203617049279 NA Possible esterase LipW II.B.5 - Esterases and lipases Rv0218 - 7.9 0 0 5.8 4.1 6.4 7.63952770230687 1.00249506609641 0.969754761694661 1.03376142680087 0.301247708463598 NA Probable conserved transmembrane protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0219 - 6.3 0 2.2 5 1.7 10.3 3.04566576455044 0.709646154963919 1.33509557863563 0.531532098764889 0.595050103996452 NA Probable conserved transmembrane protein VI - Unknowns Rv0220 lipC 460.3 341.9 239.7 387.3 388.3 319.3 694.182502038732 -0.110834333790054 0.178354985829825 -0.62142548622557 0.534319707451291 0.923128239106977 Probable esterase LipC II.B.5 - Esterases and lipases Rv0221 - 172.3 146.9 87.2 119.7 137.4 137.8 306.327189568244 -0.222005481638985 0.230892548261567 -0.96150994612215 0.336295826946078 0.854144996193932 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv0222 echA1 140.6 76.2 56.2 130.9 104 101 125.048697623802 0.154632314372856 0.246333787802751 0.627734894803292 0.530177622084053 0.922751607774049 Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0223c - 22.9 10.2 10.5 17.2 20.6 18.2 37.6265138397279 0.161004552858426 0.379582464399985 0.424162251838819 0.671447488187531 0.940710721884994 Probable aldehyde dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0224c - 8.6 9.8 4.2 7.6 16.6 5.7 10.1476346207522 0.161362860232059 0.697132060701526 0.231466703840416 0.816952249602931 NA Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0225 - 76.8 60.1 32.4 80.9 75.1 79.9 123.997478229179 0.322438201008753 0.259437325327316 1.24283659108015 0.213928055691571 0.773070552038584 Possible conserved protein II.C.5 - Other membrane proteins Rv0226c - 16.8 11.9 5.2 28.8 21.5 13.2 42.2539162334772 0.804479860738183 0.377246283365211 2.13250572957764 0.0329652939768207 0.383117660251623 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0227c - 88.6 73.4 53.5 90.6 157.2 109.9 193.653653576586 0.531624751255609 0.267611803146503 1.98655195699486 0.0469720696955051 0.437457053123795 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0228 - 16 12.7 7.6 16.2 10.6 9.6 22.8777345175603 -0.177556898070348 0.467652420102961 -0.379677064498577 0.704185147384908 NA Probable integral membrane acyltransferase IV.H - Miscellaneous transferases Rv0229c - 597.3 380.8 257.6 335.1 609.9 439 474.413480501646 0.0230084616618569 0.242977296276283 0.0946938747548437 0.924557983353551 0.995376050215915 Possible conserved membrane protein with PIN domain V - Conserved hypotheticals Rv0230c php 163.3 82.6 66.4 104.5 125 83 159.909950553826 -0.158514598910754 0.236413773439329 -0.670496463064294 0.502541360400655 0.915911629458156 Probable phosphotriesterase Php (parathion hydrolase) (PTE) (aryldialkylphosphatase) (paraoxonase) (a-esterase) (aryltriphosphatase) (paraoxon hydrolase) V - Conserved hypotheticals Rv0231 fadE4 13.5 12.1 7.3 9.7 13.4 21.4 35.8355375329994 0.203456558871458 0.439468968366314 0.46296001200674 0.643393030262881 0.939577115195416 Probable acyl-CoA dehydrogenase FadE4 I.A.3 - Fatty acids Rv0232 - 331.6 170.5 128.1 197.3 224 160.6 218.858958377769 -0.253763187796174 0.219400209552063 -1.15662235835721 0.247426683425389 0.793939325700415 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv0233 nrdB 301.5 138.4 133.2 176.1 193.2 161.7 274.922977011291 -0.263334195322721 0.212361723891746 -1.24002664179237 0.21496554019066 0.773070552038584 Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0234c gabD1 61.9 39.9 20.2 44.6 45.7 42.4 102.251663094263 -0.0161207661649642 0.275863988004805 -0.0584373708274072 0.953400248004269 0.998153412295216 Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 I.A.1 - Carbon compounds Rv0235c - 22.5 23.3 7.3 19.3 27.3 17.9 44.4424136268602 0.141873080028333 0.391387519359784 0.362487491324209 0.716987769359834 0.949890877982223 Probable conserved transmembrane protein V - Conserved hypotheticals Rv0236c aftD 53.2 31.9 19.9 87.7 51.1 36.7 300.534461552814 0.592491595027493 0.249027000752828 2.37922632178978 0.0173490204605921 0.276757764055105 Possible arabinofuranosyltransferase AftD II.C.5 - Other membrane proteins Rv0236A - 433.1 253.9 127 428 527.9 323.9 92.9668059945517 0.528316024366531 0.291173333630673 1.81443821719145 0.0696102864718914 0.524637744908043 Small secreted protein ? Rv0237 lpqI 40 26.2 15.9 76.5 33.1 39.8 68.8864197790458 0.747020358824401 0.340950038186259 2.19099655421158 0.0284520418067353 0.359339193316574 Probable conserved lipoprotein LpqI II.C.1 - Lipoproteins(lppA-lpr0) Rv0238 - 400.4 294.4 252.9 276 344.3 264.8 306.800902491881 -0.309777928842164 0.216826555700306 -1.42868998606579 0.153093357278419 0.703415658192866 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv0239 vapB24 1065.9 741.8 505.3 828 1101.4 959.9 324.64455840934 0.160418353183831 0.221155738239393 0.725363738969252 0.468228912428451 0.902523464653028 Possible antitoxin VapB24 V - Conserved hypotheticals Rv0240 vapC24 96.7 37.3 21.4 68.2 58.5 40.7 34.8544638540192 0.0282966467181229 0.421536279074964 0.0671274291745854 0.946480257815056 0.998153412295216 Possible toxin VapC24 Contains PIN domain VI - Unknowns Rv0241c htdX 491.1 279.4 302.5 218 279.5 311.8 436.024205049265 -0.591095276683317 0.241532433564066 -2.44727081974492 0.0143942635802417 0.263608158955562 Probable 3-hydroxyacyl-thioester dehydratase HtdX VI - Unknowns Rv0242c fabG4 477.3 279.6 225.1 323.5 251.4 201.6 638.582185630558 -0.50009303504994 0.179271779838811 -2.78958035391622 0.00527763983462477 0.140727431742496 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv0243 fadA2 1188.2 676 575.3 813.7 681.1 493.9 1558.28244299417 -0.46651222402898 0.167641330635497 -2.78279957729111 0.00538920861467167 0.140727431742496 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) I.A.3 - Fatty acids Rv0244c fadE5 83.7 38.9 29 38.8 37 19.3 116.89380737794 -0.792922077442403 0.275725766898064 -2.8757634310454 0.00403051664651165 0.118600096215438 Probable acyl-CoA dehydrogenase FadE5 I.A.3 - Fatty acids Rv0245 - 105.1 61.5 39.3 104.7 97.9 114.5 66.9785178575116 0.476447449327011 0.311490933592641 1.52957084121779 0.126122991583663 0.671582561030228 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0246 - 22.1 12 4.6 13.5 11.9 7 23.2611448933945 -0.343852146206692 0.488604147289732 -0.703743814116246 0.481592329472753 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0247c - 517.8 415.7 332.1 399.6 690.7 585.1 597.853314220197 0.210250189356019 0.249192226939704 0.843726916919011 0.398822022671039 0.893826103932853 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0248c - 314.7 220.8 200.3 238.1 319.2 272.6 825.858771432905 -0.0243186866453512 0.209395612156733 -0.116137517853758 0.907543555034466 0.992210970746976 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0249c - 347.1 228 182.7 116 249.5 272.3 314.286616836268 -0.400783799313993 0.304978892822486 -1.31413618695006 0.188800378315002 0.739746500217031 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) II.C.5 - Other membrane proteins Rv0250c - 1130.3 903.6 559.8 627 811.9 731.1 379.779955147561 -0.432096650059681 0.224015664855666 -1.92886801169946 0.0537472498898509 0.482678224660154 hypothetical protein VI - Unknowns Rv0251c hsp 15.8 7.4 8.9 13.8 11.5 0 6.80045837415063 -0.367259227065579 0.834328951481065 -0.440185164872484 0.659803003466271 NA Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) III.B - Chaperones/Heat shock Rv0252 nirB 208 46.4 167.9 37.4 28.2 28 376.609309916266 -2.39848054727416 0.603765253982997 -3.97253821986534 7.1110821948294e-05 0.0052706368749394 Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB I.B.6.b - anaerobic Rv0253 nirD 98.4 14.4 73.8 18.2 8.3 3.9 21.1731714374169 -2.8876183748038 0.705806905910487 -4.09122998177354 4.29091345026957e-05 NA Probable nitrite reductase [NAD(P)H] small subunit NirD I.B.6.b - anaerobic Rv0254c cobU 23.9 18.1 3.2 29.7 19 21.4 14.9200709998906 0.569417544061433 0.602213442500726 0.945541072110404 0.344382712544474 NA Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase I.G.13 - Cobalamin Rv0255c cobQ1 23.5 6.5 13.5 30.4 25.9 16.7 44.2113224353173 0.542832745581797 0.38276074994107 1.41820378830737 0.156131276218968 0.70782226167295 Probable cobyric acid synthase CobQ1 I.G.13 - Cobalamin Rv0256c PPE2 15.5 7.4 7.4 13.7 19.5 13.6 33.1540843414141 0.440143805810928 0.401963840467402 1.09498358185435 0.273523829366493 0.813512808631955 PPE family protein PPE2 IV.C.2 - PPE family Rv0257 - 20.3 26.6 4.7 20.8 14.2 12.7 8.80969840570782 -0.253528792439166 0.762756597608455 -0.33238492231215 0.739598622242812 NA hypothetical protein ? Rv0258c - 12.6 3.8 1.1 18.3 12.8 12.4 6.17078628781212 1.34620700220523 0.943668252589062 1.42656807465098 0.153704431905015 NA hypothetical protein V - Conserved hypotheticals Rv0259c - 11 6.9 4.2 4.3 2.3 4.8 5.92330476109856 -1.14182624541661 0.89672590669906 -1.27332804470854 0.202901659001224 NA hypothetical protein V - Conserved hypotheticals Rv0260c - 12.6 4.5 7.1 1.7 1.6 4.4 9.25724032056969 -2.5216584860389 0.830155857905811 -3.03757235707539 0.0023849214027511 NA Possible transcriptional regulatory protein I.J.2 - Two component systems Rv0261c narK3 4.6 3.7 4.9 4.1 6.3 6 11.4739035392242 0.0711830693551858 0.660089758017211 0.10783846967874 0.914123826421618 NA Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator) III.A.4 - Anions Rv0262c aac 57.3 30.8 37.4 51.4 55.8 41.1 39.5931044851421 0.0348637728347081 0.368619905797235 0.0945791919709442 0.924649078135667 0.995376050215915 Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC) IV.D - Antibiotic production and resistance Rv0263c - 60.7 51.4 30.5 52.7 83.9 39 75.3425573555708 0.123439504374436 0.318884839032953 0.387097438526013 0.698684073846799 0.945942314371144 hypothetical protein V - Conserved hypotheticals Rv0264c - 35.2 30.2 15.6 41 47.5 25.2 31.872801395535 0.355817580466385 0.406856438753212 0.874553150877415 0.381817088309818 0.893490749801147 hypothetical protein V - Conserved hypotheticals Rv0265c - 103.8 79.9 47.1 95.2 59.2 64.4 118.396612261108 -0.223437224979445 0.266425651739078 -0.838647568359019 0.401667108858778 0.893826103932853 Probable periplasmic iron-transport lipoprotein III.A.2 - Cations Rv0266c oplA 13.7 9.5 7.7 14.8 11.9 12.5 67.5210308020292 0.164676729472938 0.298163603664322 0.552303257168617 0.580740599387965 0.928941202821899 Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE) V - Conserved hypotheticals Rv0267 narU 1.9 0 0 2.4 0 4.1 2.77679103833082 1.48380764372771 1.48306412665299 1.00050133845284 0.317067950222567 NA Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator) III.A.4 - Anions Rv0268c - 88.7 47.7 44.9 74.9 82.7 137.3 65.131166300615 0.528652686166959 0.355982610269381 1.48505199668859 0.137530050729041 0.682181933169668 Hypothetical protein VI - Unknowns Rv0269c - 24 12.6 5.4 18 10.6 14.2 25.6644569466808 -0.0729013128677765 0.466993850454436 -0.156107650661429 0.87594816794389 NA hypothetical protein V - Conserved hypotheticals Rv0270 fadD2 471.7 338.5 208.7 331.2 395.7 287.3 910.968528994288 -0.168182082591092 0.187580114647013 -0.896588014713478 0.369938795836122 0.885048465556592 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0271c fadE6 76.4 37.7 43.6 46.4 36.2 39.8 165.731803934597 -0.55516356929263 0.242176241257578 -2.29239485430017 0.0218828686893982 0.307248806065357 Probable acyl-CoA dehydrogenase FadE6 I.A.3 - Fatty acids Rv0272c - 68.6 49.9 44.6 49.9 54.9 51.9 98.4659212335327 -0.273057218553626 0.27546069428779 -0.991274705306401 0.321551460803043 0.849868688356633 hypothetical protein VI - Unknowns Rv0273c - 68.5 44.4 36.2 40.8 47.6 47.6 47.1056769511846 -0.344962911517636 0.348103628100209 -0.990977639044691 0.321696499171871 0.849868688356633 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0274 - 101.4 70.3 33.8 56.2 91.9 41 59.6296675748736 -0.259139948602749 0.348138441611288 -0.744358903324127 0.456659374649057 0.901158530199572 hypothetical protein VI - Unknowns Rv0275c - 297.7 154 102.5 230 261.8 187.4 232.052233417636 0.168659911184985 0.223757442718606 0.753762239753023 0.450992001472004 0.901158530199572 Possible transcriptional regulatory protein (possibly TetR-family) I.A.3 - Fatty acids Rv0276 - 223 123.7 86.5 152.4 118.9 81.5 188.948773626664 -0.427716128319519 0.232783172830108 -1.83740140285689 0.0661506598880068 0.514454587842348 hypothetical protein V - Conserved hypotheticals Rv0277c vapC25 272.8 152.3 144.3 138.3 239.8 204.4 132.669671061661 -0.167039976858519 0.286160558527916 -0.583728161972481 0.559403216951322 0.92521033104044 Possible toxin VapC25 Contains PIN domain V - Conserved hypotheticals Rv0278c PE_PGRS3 5.5 1.9 3 6.2 3 5.9 18.9881548017624 0.34597313090256 0.529622818936039 0.653244381723557 0.513598742235364 NA PE-PGRS family protein PE_PGRS3 IV.C.1.b - PE_PGRS subfamily Rv0279c PE_PGRS4 26 7.4 7.1 21.4 6.6 7.9 47.1159118968541 -0.214450243136105 0.443880276796963 -0.483126316590538 0.629006049294191 0.93413540068838 PE-PGRS family protein PE_PGRS4 IV.C.1.b - PE_PGRS subfamily Rv0280 PPE3 203.5 122.2 101 163.4 200.7 207.5 429.38925242074 0.267018393358904 0.217607343441054 1.22706517682954 0.219798094958822 0.773070552038584 PPE family protein PPE3 IV.C.2 - PPE family Rv0281 - 169.5 94.9 69.8 121.2 135.1 79.1 158.774759870894 -0.146629733619512 0.23519004546799 -0.62345212497299 0.532987453590104 0.923128239106977 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0282 eccA3 577.4 442.8 328.1 420 531.3 439.6 1406.88924218899 -0.142519390384932 0.192863192397508 -0.738966251741739 0.459927490483589 0.901158530199572 ESX conserved component EccA3 ESX-3 type VII secretion system protein V - Conserved hypotheticals Rv0283 eccB3 232.3 134.3 120.3 273.7 192.5 163.7 474.671561131049 0.195196464062034 0.194911888846711 1.00146001979154 0.316604459567968 0.847340730510678 ESX conserved component EccB3 ESX-3 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv0284 eccC3 222.2 152.3 129.6 236.4 272.2 215.1 1309.05093209278 0.330895746473924 0.177313523196123 1.86616192893492 0.0620187137453724 0.513474618974024 ESX conserved component EccC3 ESX-3 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv0285 PE5 229 147.1 117.8 338.6 190.5 146.3 93.587217456727 0.305560473122464 0.296664271507356 1.02998743856113 0.30301590230003 0.8432011929194 PE family protein PE5 IV.C.1.a - PE subfamily Rv0286 PPE4 219.7 136.6 134.4 261.1 183.4 208 471.712821084352 0.218004923717133 0.205171257949258 1.0625509922596 0.287985621716244 0.829758572569927 PPE family protein PPE4 IV.C.2 - PPE family Rv0287 esxG 510.5 322.6 285 562.8 605.4 591.7 225.178708729197 0.472612984574451 0.220793863426035 2.14051684789136 0.0323130207190563 0.383117660251623 ESAT-6 like protein EsxG (conserved protein TB9.8) V - Conserved hypotheticals Rv0288 esxH 1017.5 692.7 574.5 856.2 1166.9 835.5 400.427933228457 0.136673505235028 0.209385134604976 0.652737385072131 0.513925596531228 0.915911629458156 Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4) V - Conserved hypotheticals Rv0289 espG3 396.2 220.3 161.7 396.3 284 201.1 382.937250435681 0.0331340989015478 0.210832503358938 0.157158400026857 0.875120012790519 0.980389613357057 ESX-3 secretion-associated protein EspG3 V - Conserved hypotheticals Rv0290 eccD3 173.6 106.7 65.4 217.4 113.8 79.4 275.888391988534 0.0982574124281467 0.268113724745059 0.366476623013524 0.714009453262239 0.949890877982223 ESX conserved component EccD3 ESX-3 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv0291 mycP3 335.1 189.1 176.9 355.7 245.3 220.2 557.79182700741 0.049396770433887 0.193325192873177 0.255511295241752 0.798328220736144 0.965592404376002 Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) II.C.5 - Other membrane proteins Rv0292 eccE3 136.9 74.8 53.4 134 101.3 51 141.061380851339 -0.0257413635305518 0.272872585859683 -0.0943347366663962 0.924843257069741 0.995376050215915 ESX conserved component EccE3 ESX-3 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv0293c - 112.5 60.8 47.6 84.7 72.9 82.6 146.147878279234 -0.027242408368906 0.240822802448541 -0.113122213062557 0.909933664549655 0.992834063067731 hypothetical protein V - Conserved hypotheticals Rv0294 tam 4 6.3 1.4 4 2.1 0 3.14333864493639 -0.805541400554842 1.24207020791863 -0.648547397255995 0.516630965460831 NA Probable trans-aconitate methyltransferase Tam V - Conserved hypotheticals Rv0295c - 54.5 24.3 29.5 61.4 57.6 26 52.0334330591597 0.260961292134664 0.348360883026118 0.74911192630976 0.453789747308881 0.901158530199572 hypothetical protein VI - Unknowns Rv0296c - 12.7 15.3 5.4 13.7 14.9 9.2 25.6433214446038 0.0365382148284323 0.464763279338537 0.0786168280773697 0.937337402097369 NA Probable sulfatase I.C.5 - Sulphur metabolism Rv0297 PE_PGRS5 85.6 52.4 35.5 88.1 73 58.3 181.247657857748 0.193261059181449 0.222133992866661 0.870020192260516 0.384289369458853 0.893826103932853 PE-PGRS family protein PE_PGRS5 IV.C.1.b - PE_PGRS subfamily Rv0298 - 1207.3 637.8 501.4 940.8 1218.9 719.2 310.383971055885 0.146231194466264 0.214334524926123 0.682256834341864 0.495076562567146 0.913636152872564 Hypothetical protein VI - Unknowns Rv0299 - 766.5 468.8 346 623.6 627.2 372.3 255.276530630214 -0.124015742107538 0.209932181946431 -0.590741928930094 0.554693349663138 0.92521033104044 Hypothetical protein VI - Unknowns Rv0300 vapB2 864.6 525.9 337.9 828.5 699.7 504.5 216.834463039192 0.0953854218999452 0.21890886750244 0.435731192565244 0.663031771489373 0.939577115195416 Possible antitoxin VapB2 VI - Unknowns Rv0301 vapC2 630 431.5 378.6 520 483.9 431.5 330.984341932441 -0.197977695812602 0.198076719107873 -0.999500076052767 0.317552502256624 0.847340730510678 Possible toxin VapC2 V - Conserved hypotheticals Rv0302 - 140.8 84.6 68.3 137 108.4 107.3 107.951539338202 0.102697429910399 0.25357457235177 0.404998927762886 0.685478299103578 0.942913432418385 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv0303 - 52.5 43.8 38.5 44.8 63.4 38 69.2283093992948 -0.102860494084826 0.321802552136267 -0.319638528041474 0.749242364209223 0.957707961696119 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0304c PPE5 9.1 8.3 6.6 3.7 13.1 8.5 90.0241823547816 -0.160064126067534 0.395423276458095 -0.404791866329339 0.685630508021057 0.942913432418385 PPE family protein PPE5 IV.C.2 - PPE family Rv0305c PPE6 14.1 8.9 8.6 10.5 13.8 20.6 59.7739365092924 0.299522938129435 0.369010677333732 0.811691792480431 0.41696850504624 0.901158530199572 PPE family protein PPE6 IV.C.2 - PPE family Rv0306 - 2.6 2.6 1.6 0.8 0 0 1.00637263168587 -2.15444104490309 2.03027817374427 -1.06115559570334 0.288619195442543 NA Putative oxidoreductase I.G.13 - Cobalamin Rv0307c - 15 12.3 6.7 24.5 22.6 0 9.40347444581548 0.387994581845324 0.740057705167929 0.524276119464608 0.600086504045153 NA hypothetical protein VI - Unknowns Rv0308 - 91.8 57 40.1 98.7 65.5 54.1 75.5984065052328 0.0725613799791865 0.296403390700603 0.244806173801435 0.806606513351047 0.965592404376002 Probable conserved integral membrane protein V - Conserved hypotheticals Rv0309 - 239.8 98.9 103.4 261.2 212.5 167.7 183.408099290203 0.391503768208166 0.235338703126757 1.66357578675572 0.0961972339969857 0.606108312609709 Possible conserved exported protein VI - Unknowns Rv0310c - 19.1 21.1 6.8 4.4 5.6 0.6 7.47410206494875 -2.41122853550163 0.910184744787854 -2.64916386405009 0.00806911967928738 NA hypothetical protein V - Conserved hypotheticals Rv0311 - 22.7 9.5 7.5 24.9 31.4 16.1 34.2903669466016 0.693609527644065 0.40486968058476 1.71316737435679 0.0866817519390068 0.569906516107151 hypothetical protein VI - Unknowns Rv0312 - 35.9 27 15.6 53.1 45.4 35.3 102.520435170653 0.622715886003665 0.262797632582144 2.36956429129558 0.0178090585331081 0.276757764055105 Conserved hypothetical proline and threonine rich protein V - Conserved hypotheticals Rv0313 - 636 337.5 284.5 911.8 531.4 523.6 323.618620160802 0.491221605415952 0.222877506151574 2.20399812389269 0.027524476028171 0.352041830732016 hypothetical protein VI - Unknowns Rv0314c - 201.3 134.3 84.6 143.1 165.2 107 145.761884641813 -0.184089958412682 0.240129515107607 -0.766627785552259 0.443302850447183 0.901158530199572 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0315 - 70.9 50.8 27.4 129.4 104.5 101.8 110.932368785868 1.04040721298592 0.262184395860271 3.96822705474966 7.24093279998906e-05 0.0052706368749394 Possible beta-1,3-glucanase precursor II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv0316 - 37.8 45.1 17.3 62.2 64.1 50.8 44.4407182583181 0.701870662423477 0.376348687373324 1.86494781560709 0.0621887192177505 0.513474618974024 Possible muconolactone isomerase II.B.6 - Aromatic hydrocarbons Rv0317c glpQ2 144 122.5 57.1 121.8 117.9 85.7 132.045375844713 -0.145495147866684 0.262295893655954 -0.554698534691993 0.579100878624864 0.928575669725434 Possible glycerophosphoryl diester phosphodiesterase GlpQ2 (glycerophosphodiester phosphodiesterase) I.C.1 - General Rv0318c - 6 0 1.3 5.7 2.3 3.6 2.91980584382509 0.355899825964641 1.28624484480146 0.276696794862239 0.782012933153776 NA Probable conserved integral membrane protein ? Rv0319 pcp 39.7 27.7 18 48.9 34.9 25.4 33.536594340387 0.264445033680955 0.392966418122924 0.672945629665062 0.500981881493062 0.915911629458156 Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase) II.B.3 - Proteins, peptides and glycopeptides Rv0320 - 19.3 14.9 1.6 25.9 18.4 19.5 16.0428029054603 0.796464300042974 0.604154175733379 1.31831299365953 0.187398893014464 NA Possible conserved exported protein V - Conserved hypotheticals Rv0321 dcd 36.8 24.1 25.2 37.4 30.9 18.6 26.2955554343612 -0.14597386268178 0.43960417829928 -0.332057496010427 0.739845844108307 NA Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0322 udgA 6.1 3.3 1.2 4.8 1.6 2.1 5.88479735129468 -0.368253315455991 0.899721036084232 -0.409297216233493 0.682321558179435 NA Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH) I.C.3 - Sugar nucleotides Rv0323c - 31.7 9.9 17.7 27.1 16 21 21.3229720207775 -0.090901695126872 0.49783284846214 -0.182594811506869 0.855115955718801 NA hypothetical protein V - Conserved hypotheticals Rv0324 - 31.4 35.1 14.5 29.3 19.7 12.5 25.9918761856268 -0.486731889052594 0.470320046053233 -1.03489505313899 0.300717925129564 NA Possible transcriptional regulatory protein (possibly ArsR-family) I.J.1 - Repressors/activators Rv0325 - 21.5 13.1 10.7 15.9 14.4 0 3.67276763857289 -0.664387294921616 1.10006630389366 -0.603952045953986 0.545875524704618 NA Hypothetical protein VI - Unknowns Rv0326 - 16.3 13.3 7.9 15.9 15.4 16 9.60521310026206 0.205740579904116 0.675889815531632 0.304399585814571 0.760823483301549 NA Hypothetical protein VI - Unknowns Rv0327c cyp135A1 4.7 2.5 1.6 3.2 3.9 8.4 8.09309802049777 0.500513902461 0.780354554381741 0.641392940748 0.521267418268268 NA Possible cytochrome P450 135A1 Cyp135A1 IV.F - Cytochrome P450 enzymes Rv0328 - 60.7 40.8 14.5 48.6 55.4 28.8 37.8796339818136 0.106528880930554 0.402500743354484 0.264667538357149 0.791265586576045 0.964516371138273 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) I.J.1 - Repressors/activators Rv0329c - 4.2 8.3 5 3.7 8.9 0 5.0932689996123 -0.566089688475148 1.00109113807479 -0.565472679704068 0.57175230178101 NA hypothetical protein V - Conserved hypotheticals Rv0330c - 7.2 17.5 1.4 11.5 7.5 3.8 9.01680022890056 -0.261966198918964 0.840003895439673 -0.311863076279957 0.755144584825003 NA Hypothetical protein VI - Unknowns Rv0331 - 9.8 6.6 3.5 7.1 5.9 4.7 11.1119698031016 -0.275382035901702 0.635606075463758 -0.433258973650896 0.664826639603841 NA Possible dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0332 - 30.3 28.1 16.5 34.2 17.6 21.6 31.113422542236 -0.16609282915707 0.424842155327499 -0.390951856058243 0.695832822589983 0.944008157375819 hypothetical protein VI - Unknowns Rv0333 - 75.3 46.8 46.8 74.5 57.8 15.1 31.1020295655528 -0.353209391470935 0.445032906540944 -0.793670279836798 0.427387406479341 0.901158530199572 hypothetical protein VI - Unknowns Rv0334 rmlA 23.9 23.1 14.4 20.2 48.7 28.5 36.4775919070827 0.455912350829927 0.436808783223769 1.04373439440748 0.296608292181122 0.837161771605085 Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase) I.C.3 - Sugar nucleotides Rv0335c PE6 7.5 3.3 5.4 7.3 11 0 4.27421609157838 0.131527008388031 1.03307834518756 0.127315618414354 0.89869059919276 NA PE family protein PE6 IV.C.1.a - PE subfamily Rv0336 - 108.1 70 60.4 183.9 104.9 89.1 243.623191516848 0.476677840301925 0.241057058866406 1.9774481715804 0.0479909934614767 0.441006936592839 Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0337c aspC 189.1 98.9 113.8 131.2 169.1 104.1 278.606810071945 -0.190744324615332 0.226759226123544 -0.841175584676806 0.400249576234355 0.893826103932853 Probable aspartate aminotransferase AspC (transaminase A) (ASPAT) I.D.2 - Aspartate family Rv0338c - 277.9 159 136.5 231.5 240.1 197.5 872.831728074262 0.0589136737060099 0.168697342594051 0.349227040569205 0.7269188671957 0.949890877982223 Probable iron-sulfur-binding reductase V - Conserved hypotheticals Rv0339c - 32.3 20.9 12.5 33.2 37.2 25.9 104.964538447486 0.404872723891286 0.261926791084563 1.54574765801858 0.122165522519658 0.665646250765128 Possible transcriptional regulatory protein V - Conserved hypotheticals Rv0340 - 104.6 49.4 33.4 83.7 40.5 55.4 50.505294900387 -0.175120137156473 0.366135824958574 -0.478292822550995 0.632441804176502 0.93413540068838 hypothetical protein VI - Unknowns Rv0341 iniB 45.3 20.6 10.4 50.6 40.6 24.3 68.4556622744531 0.503142062297101 0.342080131202184 1.47083100245809 0.141336825936247 0.684654396741958 Isoniazid inductible gene protein IniB V - Conserved hypotheticals Rv0342 iniA 50.8 33.8 28.8 37.7 38.3 48.1 123.474395879254 -0.0664926991610321 0.268444504600212 -0.247696257593569 0.80436942766597 0.965592404376002 Isoniazid inductible gene protein IniA V - Conserved hypotheticals Rv0343 iniC 48.8 18.3 20.8 37.1 34.2 29.9 72.5571179571768 0.0435653647642789 0.302646770094945 0.143947892622848 0.885541616632877 0.982420376752145 Isoniazid inductible gene protein IniC V - Conserved hypotheticals Rv0344c lpqJ 12.4 11.5 6.2 3.6 7.2 4.1 6.41428423023106 -1.42750276754464 0.877039129965965 -1.62763862953302 0.103601533075852 NA Probable lipoprotein LpqJ II.C.1 - Lipoproteins(lppA-lpr0) Rv0345 - 24.9 0.1 17.4 35.4 41.1 15.5 13.5939485699718 0.806560304719822 0.669002637460532 1.20561603132305 0.227965574943071 NA hypothetical protein II.C.5 - Other membrane proteins Rv0346c ansP2 195.1 156.5 145.8 154.1 211.5 184.4 421.321946041172 -0.08205967898068 0.237049678985039 -0.346170808296513 0.729214351639979 0.949983374253025 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) III.A.1 - Amino acids Rv0347 - 34.4 23.5 11.6 19.5 23.6 40.3 40.0091521814119 0.102832491509606 0.422570852810826 0.243349702956539 0.807734503956129 0.965592404376002 Probable conserved membrane protein V - Conserved hypotheticals Rv0348 - 20.2 14.1 18 16.1 27.1 20 20.0597361034721 0.0092196225599943 0.518584546798346 0.0177784367407681 0.985815607030098 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0349 - 27.3 11.3 13.3 21.3 37 17.5 21.3018681564162 0.327786574152338 0.494161349796289 0.663318922630156 0.507126319965152 NA Hypothetical protein VI - Unknowns Rv0350 dnaK 385.1 178.4 301.7 189.6 225.3 142 739.685901611106 -0.877322821453612 0.251442687813994 -3.48915623309999 0.000484547856397544 0.0268051874159121 Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70) III.B - Chaperones/Heat shock Rv0351 grpE 414.8 196.9 622 238.5 281.1 255.6 419.992191455101 -1.0120486796884 0.631190602960349 -1.60339630365502 0.108847186599518 0.643080319504058 Probable GrpE protein (HSP-70 cofactor) III.B - Chaperones/Heat shock Rv0352 dnaJ1 395.1 133.8 203.4 231.5 174.7 139.1 401.469123151249 -0.581685454519259 0.245397455771075 -2.37038095073772 0.0177697655548771 0.276757764055105 Probable chaperone protein DnaJ1 III.B - Chaperones/Heat shock Rv0353 hspR 329.3 170.1 292.7 286.4 240.7 180.6 156.992318206879 -0.420342245098263 0.289863802846418 -1.45013706772135 0.147020300157469 0.695223866622759 Probable heat shock protein transcriptional repressor HspR (MerR family) III.B - Chaperones/Heat shock Rv0354c PPE7 20 2.4 14.2 3 22 20.9 9.23432897525551 -0.0716490280903323 0.863488353579314 -0.0829762530013685 0.933870421845418 NA PPE family protein PPE7 IV.C.2 - PPE family Rv0355c PPE8 33.9 27 27.1 13.6 33.7 30.7 462.030512489393 -0.379514832370587 0.504963239470036 -0.751569228621259 0.452310154126549 0.901158530199572 PPE family protein PPE8 IV.C.2 - PPE family Rv0356c - 38.1 17.1 13.9 42.7 27.2 21.1 25.6976562507927 0.294832278086122 0.451451506860534 0.653076296358899 0.513707092742201 NA hypothetical protein VI - Unknowns Rv0357c purA 44.3 17.5 21.3 30.2 45.3 40.6 67.8624325555255 0.313862210955877 0.334348792950593 0.938726915046037 0.347870970882884 0.862969601311263 Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase) I.F.1 - Purine ribonucleotide biosynthesis Rv0358 - 12.4 2.6 5.1 8.3 9.5 4.4 6.21929920927432 -0.105069310725127 0.863322887160556 -0.121703376903046 0.90313393873968 NA hypothetical protein VI - Unknowns Rv0359 - 5.9 0.7 5.2 11.7 6.1 3.6 6.04592765936608 0.626581413299878 0.922293359965642 0.679373223854956 0.496901411231289 NA Probable conserved integral membrane protein V - Conserved hypotheticals Rv0360c - 28.1 16.7 19.3 19.7 26.5 17.6 14.7679735268558 -0.288486495361926 0.563846255621421 -0.511640349626837 0.608902740570268 NA hypothetical protein VI - Unknowns Rv0361 - 158.1 139 125.1 140.6 173.7 146.2 200.976343706104 -0.113340434690321 0.254616580621393 -0.445141610234939 0.656217420010388 0.939577115195416 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0362 mgtE 36.4 30.2 18.8 28.5 29.5 21.7 60.6642499821216 -0.28603153764529 0.314870096468424 -0.908411249125953 0.363660984617773 0.882928450686174 Possible Mg2+ transport transmembrane protein MgtE III.A.2 - Cations Rv0363c fba 298.7 211.7 147.4 215.3 227.4 144.8 344.078899980306 -0.338602681743182 0.198788905118803 -1.70332786701965 0.0885067283484115 0.571985071522678 Probable fructose-bisphosphate aldolase Fba I.B.1 - Glycolysis Rv0364 - 152.8 87.7 85.3 125.5 157.5 168.5 142.370876584114 0.277754099909543 0.264374111292489 1.05061005614976 0.293437720555354 0.835029562814927 Possible conserved transmembrane protein V - Conserved hypotheticals Rv0365c - 45.6 24.5 19.1 39.3 56 16.1 57.6103002936766 0.165938854576533 0.357653213454698 0.463965786784555 0.64267225806714 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv0366c - 35.4 8.5 33 26.5 47 19.1 26.4879634052801 -0.0118441460168407 0.525048938403186 -0.0225581753443059 0.982002706570114 NA hypothetical protein V - Conserved hypotheticals Rv0367c - 86.1 86 46.7 107.7 88.3 65.5 49.8274966452887 0.119969531541247 0.348585730030292 0.34416076507441 0.730725386893533 0.951146550657653 Hypothetical protein VI - Unknowns Rv0368c - 1 2.1 0 3.2 1.6 4.6 3.52032231144762 1.56596410176275 1.20376000463927 1.30089394541067 0.193294758841646 NA hypothetical protein V - Conserved hypotheticals Rv0369c - 15 10 4.2 28.7 24.8 5.5 10.6820830750518 0.874209403552319 0.695492963945149 1.25696369175816 0.208766783346978 NA Possible membrane oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0370c - 7.5 7.7 1.2 8.6 8.2 18.9 11.9468850573751 1.09657730672915 0.70835891490319 1.54805323072558 0.121609481064593 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0371c - 2.2 0 0 0 0 1.7 0.246404312419416 -1.44807660097886 4.01837763931354 -0.360363492672189 0.71857532382433 NA hypothetical protein II.C.5 - Other membrane proteins Rv0372c - 1 0 0.7 1.2 0 6.2 1.29500471079769 1.88329328052679 2.02061744338687 0.93203851460873 0.35131662151939 NA hypothetical protein V - Conserved hypotheticals Rv0373c - 6.7 5 4.5 7.3 7.7 2.4 20.6642736090761 -0.0564880757212389 0.497404302647013 -0.113565715898775 0.90958206622217 NA Probable carbon monoxyde dehydrogenase (large chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0374c - 3.6 0 0.8 3.5 2.2 0.4 0.975578724967373 0.648124087086232 2.15364527217993 0.300942822598727 0.763458095322781 NA Probable carbon monoxyde dehydrogenase (small chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0375c - 2.9 0 1.9 5.1 4 2.9 3.26795454969129 1.08896882777108 1.16259782115964 0.93666856065916 0.348929073081158 NA Probable carbon monoxyde dehydrogenase (medium chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0376c - 6.7 1.5 0.9 9 1.4 2.5 5.15385002165484 0.523365464464283 1.05771787006276 0.494806298803698 0.62073685770809 NA hypothetical protein V - Conserved hypotheticals Rv0377 - 31.2 21.7 17.2 24.3 12.4 11.7 30.0340641197889 -0.688359776752026 0.433843804494454 -1.58665346749426 0.112591150678755 0.648445531184945 Probable transcriptional regulatory protein (probably LysR-family) I.J.1 - Repressors/activators Rv0378 - 2.2 3.5 0 0.4 0.4 1.2 0.0896015681525148 -0.706868028450054 4.02314057484366 -0.17570055415663 0.860529199923768 NA Conserved hypothetical glycine rich protein V - Conserved hypotheticals Rv0379 secE2 131.8 34.7 39 64.2 58 25.7 18.8039095150008 -0.592949003328907 0.541245956030769 -1.09552597432284 0.273286272511008 NA Possible protein transport protein SecE2 III.D - Protein and peptide secretion Rv0380c - 59.5 20.4 21.1 32.1 40.9 29.2 28.3017909654173 -0.161717499360987 0.439732877993198 -0.367763038549709 0.713049931421102 0.949890877982223 Possible RNA methyltransferase (RNA methylase) IV.H - Miscellaneous transferases Rv0381c - 58.4 24.8 26.8 46.9 37.2 44.8 56.7308558229397 0.0692359615689672 0.329635948500008 0.210037654825034 0.833638284172077 0.970064574682358 Hypothetical protein VI - Unknowns Rv0382c pyrE 273.4 154.7 119.8 233 153.6 164.3 156.030376926605 -0.135636644421686 0.239477915596822 -0.566384771153763 0.571132244897457 0.925455061151943 Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv0383c - 608.1 335.5 267.3 468.4 410.9 313.9 541.462582301566 -0.171333277787633 0.178301757155793 -0.960917494704943 0.336593653597753 0.854144996193932 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0384c clpB 39.2 21.6 18.3 39.8 34.6 31 123.13547677597 0.249055973555645 0.241490200797903 1.0313295228243 0.302386318286742 0.842296632810805 Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) III.B - Chaperones/Heat shock Rv0385 - 15.4 7.4 5.9 15.5 4.5 5.1 15.433866124164 -0.29316296084136 0.606458695199468 -0.483401364613853 0.628810779455966 NA Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0386 - 14.3 6.9 6 16.9 7.5 8.8 50.2660875306916 0.167344768884 0.366403141086595 0.456723073900858 0.647870103872069 0.939577115195416 Probable transcriptional regulatory protein (probably LuxR/UhpA-family) I.J.1 - Repressors/activators Rv0387c - 5.6 0 2.9 4.8 6.8 1.5 3.38099048271702 0.205231978733723 1.18849027024288 0.172682927132236 0.862900664353591 NA hypothetical protein V - Conserved hypotheticals Rv0388c PPE9 9.8 3.6 7.6 7.3 7.5 1 4.62615907090392 -0.58854733664294 1.01569287576137 -0.57945403643967 0.562282852003275 NA PPE family protein PPE9 IV.C.2 - PPE family Rv0389 purT 34.6 6.6 17.5 40.1 28.1 20.9 47.25417903307 0.413943882418085 0.400410907949602 1.03379771679493 0.301230739252275 0.842296632810805 Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase) I.F.1 - Purine ribonucleotide biosynthesis Rv0390 - 78 29.6 27.4 68.1 29.4 17.2 26.5105827194018 -0.316818085861163 0.489584708583521 -0.647115974634481 0.51755688720367 NA hypothetical protein VI - Unknowns Rv0391 metZ 42.8 25.2 16.5 49.1 30 23.2 58.3361325958242 0.159485921684124 0.333457609656018 0.478279448619101 0.632451321724618 0.93413540068838 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) I.D.2 - Aspartate family Rv0392c ndhA 44.3 33 26.8 36.2 27.5 30.9 75.8893606288119 -0.327662604853961 0.293273547693567 -1.11725932130888 0.2638834630782 0.80816433845196 Probable membrane NADH dehydrogenase NdhA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0393 - 1.1 0 0 1.4 0 0 0.663118299067444 0.347498702990572 2.6626980687259 0.130506236164001 0.896165920594963 NA Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0394c - 44.1 31.2 23.4 39.6 31.4 25.8 36.7372635079166 -0.202919735117416 0.375781918810207 -0.539993344437371 0.589201622355253 0.928941202821899 Possible secreted protein VI - Unknowns Rv0395 - 2.2 0 1.5 0 0.5 0 0.156802744266901 -1.09373598727695 4.02036243158163 -0.272049101515128 0.785584265026673 NA Hypothetical protein VI - Unknowns Rv0396 - 1.8 0 0 3.6 1.8 0 0.431932914286189 0.759689793091703 3.12457935471546 0.243133461131406 0.807902010556242 NA Hypothetical protein VI - Unknowns Rv0397 - 2.5 0 0 1.7 0 7.1 0.737103923551361 0.54269678062428 2.47006014132231 0.219709946144775 0.826097058030959 NA Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0397A - 111.7 34.9 25.1 114.2 124.7 86.1 30.3376219010294 0.796438306212004 0.449615829807107 1.77137514609681 0.0764983387644357 0.545639518948021 hypothetical protein ? Rv0398c - 37.7 22.1 16.7 21.1 17 9.6 20.1363855680435 -0.840569210999879 0.499415250472537 -1.68310681382787 0.0923544156706986 NA Possible secreted protein VI - Unknowns Rv0399c lpqK 54.7 34.1 40.4 33 22.6 30.9 73.5133539299251 -0.803184221415279 0.31874963826161 -2.51979649544284 0.0117422700536439 0.228726189918162 Possible conserved lipoprotein LpqK II.C.1 - Lipoproteins(lppA-lpr0) Rv0400c fadE7 90.8 55.6 48.3 65.1 55.9 38.1 111.587709796082 -0.464859064696389 0.255423602751367 -1.81995344082939 0.068766095527537 0.520912460856883 Acyl-CoA dehydrogenase FadE7 I.A.3 - Fatty acids Rv0401 - 13 4.4 4.1 24 7.6 22.8 6.7964984700535 1.24145641348154 0.867978681381174 1.43028445296153 0.152635395087919 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0402c mmpL1 20 17.3 11.9 14.4 30.3 27.3 94.4847719122029 0.344880997148425 0.342293601399862 1.00755899537117 0.313666222380965 0.846375455062714 Probable conserved transmembrane transport protein MmpL1 II.C.4 - Conserved membrane proteins Rv0403c mmpS1 12.7 9.3 8.6 17.7 17.5 6.8 7.1107397645816 0.295229162390295 0.787201896802947 0.375036142048572 0.707633587626979 NA Probable conserved membrane protein MmpS1 II.C.4 - Conserved membrane proteins Rv0404 fadD30 52.9 34.5 22.5 38.4 61.1 68.5 129.703207107998 0.45922571523031 0.301583580609839 1.5227145798246 0.127830128707636 0.671582561030228 Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv0405 pks6 61.7 53.3 39.6 64.4 72.7 82.3 427.503103073161 0.309984135653311 0.234471511385167 1.32205458062706 0.186149976597339 0.739746500217031 Probable membrane bound polyketide synthase Pks6 I.I - Polyketide and non-ribosomal peptide synthesis Rv0406c - 21.5 12.5 9.8 19.6 21.4 8 18.6766457545287 -0.0021969044391734 0.511892352864785 -0.00429173131202002 0.996575704359021 NA Beta lactamase like protein V - Conserved hypotheticals Rv0407 fgd1 56.7 37.8 32.1 47.7 50.8 36.8 70.3646082426501 -0.10398777642664 0.292919814351575 -0.355004241201073 0.722586413900484 0.949890877982223 F420-dependent glucose-6-phosphate dehydrogenase Fgd1 IV.G - Coenzyme F420-dependent enzymes Rv0408 pta 67.3 42.1 43.1 52.7 65.9 59.3 185.154931426233 0.0154219339715936 0.24391515733521 0.0632266323260895 0.949586037672797 0.998153412295216 Probable phosphate acetyltransferase Pta (phosphotransacetylase) I.A.1 - Carbon compounds Rv0409 ackA 85.2 57.4 42.6 86.4 49.3 36.4 108.719228845252 -0.261035257555979 0.287544944975812 -0.90780680417782 0.363980302862663 0.882928450686174 Probable acetate kinase AckA (acetokinase) I.B.6.c - Electron transport Rv0410c pknG 165.9 81.3 75.3 91.6 94.9 61.4 339.150595627111 -0.533987138622052 0.201423714255764 -2.65106390573259 0.00802386577925487 0.179410603799313 Serine/threonine-protein kinase PknG (protein kinase G) (STPK G) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0411c glnH 163.4 98.4 74.2 96.8 61.8 66 147.432221352185 -0.722603915295619 0.244309484082941 -2.957739925685 0.0030990347094179 0.0996736047238362 Probable glutamine-binding lipoprotein GlnH (GLNBP) III.A.1 - Amino acids Rv0412c - 239.7 189.1 90.5 120.9 148.2 103 314.113213070202 -0.632418640952516 0.233275446332335 -2.71103817780952 0.00670729029964935 0.161324912772436 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0413 mutT3 70.8 37.6 34.6 88.6 56.1 30.3 53.2054912470835 0.155351474266546 0.356574831253797 0.435677060325024 0.663071051649115 0.939577115195416 Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0414c thiE 15.3 5.2 4.8 7.2 8.3 4.2 7.1888354642445 -0.589645448640095 0.798183291307593 -0.738734392289936 0.460068297478754 NA Thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate synthase) I.G.8 - Thiamine Rv0415 thiO 36 13.3 12.6 28.7 38.3 17.9 37.7371253396967 0.276748502104679 0.396206996694823 0.69849473738053 0.484867847869095 0.908019273666837 Possible thiamine biosynthesis oxidoreductase ThiO V - Conserved hypotheticals Rv0416 thiS 14.9 12.5 7.6 12.2 4.3 0 2.295056897791 -1.20903314375519 1.46497255225998 -0.825294058847753 0.409204664002526 NA Possible protein ThiS V - Conserved hypotheticals Rv0417 thiG 15.4 1.3 5.6 14 9.1 3.7 8.6547309075292 0.113795809039582 0.786380930880354 0.144708250888265 0.884941224466887 NA Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein) I.G.8 - Thiamine Rv0418 lpqL 67.4 40.4 39.5 72.8 58.4 47.5 130.080670587449 0.102675166153248 0.244328375566953 0.420234309318328 0.674314293224481 0.941521118151901 Probable lipoprotein aminopeptidase LpqL II.C.1 - Lipoproteins(lppA-lpr0) Rv0419 lpqM 133.8 72 72 115.9 121.1 77 233.878981632108 -0.00777855734818798 0.214342968266812 -0.0362902380753881 0.971050933701425 0.998153412295216 Possible lipoprotein peptidase LpqM II.C.1 - Lipoproteins(lppA-lpr0) Rv0420c - 49.8 31.1 19.3 37.7 46.4 11.2 20.1227315621849 -0.220697356001293 0.513000607454522 -0.430208761538081 0.667043789186535 NA Possible transmembrane protein VI - Unknowns Rv0421c - 80.4 38.2 29.6 81.3 67.3 48.6 55.8837577368658 0.277551902018025 0.324776236757175 0.854594242452356 0.392775816116931 0.893826103932853 hypothetical protein VI - Unknowns Rv0422c thiD 115 49.7 41.8 110.8 75.6 49.5 89.8341236790548 0.0782762554972332 0.30005311715368 0.260874661925748 0.794189165275602 0.965360560531176 Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) I.G.8 - Thiamine Rv0423c thiC 240.2 176.1 116.3 193.1 204.4 162.1 479.233155230659 -0.101344094893545 0.188195949088623 -0.538503062283351 0.590229791546541 0.928941202821899 Probable thiamine biosynthesis protein ThiC I.G.7 - Pyridine nucleotide Rv0424c - 245.3 132.6 117 103.6 157.3 192.1 70.5073419354339 -0.329286970828036 0.342575217142729 -0.961210719136299 0.336446227822366 0.854144996193932 Hypothetical protein VI - Unknowns Rv0425c ctpH 109.2 60.7 55.6 131.8 96.3 83.3 651.115527558369 0.293455443277148 0.184510614822846 1.59045290461421 0.111732753281112 0.648445531184945 Possible metal cation transporting P-type ATPase CtpH III.A.2 - Cations Rv0426c - 156.7 122.7 125 233.4 140.7 156.8 112.373262139832 0.182644147387099 0.288217641190096 0.633702179481216 0.52627520231842 0.921428654655606 Possible transmembrane protein VI - Unknowns Rv0427c xthA 40.6 29 19.3 44.5 62.7 42.5 54.2117954158844 0.565431852489241 0.332866407197997 1.69867502476124 0.0893804317372681 0.576285021410917 Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0428c - 19.6 21.3 5 21.4 17.8 5.8 20.9097486155811 -0.0970672596400794 0.535195595129147 -0.181367822387731 0.856078874013507 NA GCN5-related N-acetyltransferase VI - Unknowns Rv0429c def 43.7 35.6 21.2 49.3 47.4 38.1 36.5354379644937 0.27576881897396 0.376479321601588 0.732493933002233 0.463867144434923 0.901158530199572 Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) II.A.6 - Protein translation and modification Rv0430 - 68.5 27.7 19.2 149.2 83.3 79.1 32.6542179785006 1.29979345045711 0.432458624995285 3.00559030467084 0.00265065874508639 0.0894112449866945 hypothetical protein VI - Unknowns Rv0431 - 97.1 68 59.4 75.7 64.1 80.5 59.3095923223042 -0.23880302982951 0.322493485604793 -0.74048946874591 0.459003048978024 0.901158530199572 Putative tuberculin related peptide II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0432 sodC 214.2 141.6 97.4 218.6 235.2 147.7 199.24119347063 0.246759866683113 0.219223482687765 1.12560873341551 0.260331169807151 0.80455420747104 Periplasmic superoxide dismutase [Cu-Zn] SodC III.F - Detoxification Rv0433 - 199.6 140.2 85.7 223 189.4 167.9 298.758721489675 0.294019297951456 0.202378219644071 1.45282085428243 0.146273500192593 0.693983707603282 hypothetical protein V - Conserved hypotheticals Rv0434 - 94.5 42.3 49.6 127.4 63.7 82.8 78.086416714147 0.390204492636486 0.317250159348362 1.22995838185857 0.218712690030509 0.773070552038584 hypothetical protein V - Conserved hypotheticals Rv0435c - 51.8 33.5 27.9 67.9 46.4 27.4 145.401385567983 0.156597942006907 0.264019700739565 0.593129761030137 0.553094314612545 0.92521033104044 Putative conserved ATPase III.C - Cell division Rv0436c pssA 84.5 56.3 29.1 73.3 78.9 89.4 93.0175308925106 0.367893084613849 0.292645952730423 1.25712684963302 0.20870770611933 0.770341510876847 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0437c psd 43.3 10.4 23.6 40.7 40.6 23.6 32.3031445600954 0.229333640421306 0.428633391782907 0.535034471923407 0.592626020448949 0.928941202821899 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0438c moeA2 21.8 13.9 19.7 28.2 22.4 25.2 43.3795959276196 0.219032340808571 0.380143550000585 0.576183236064991 0.564491335059793 0.92521033104044 Probable molybdopterin biosynthesis protein MoeA2 I.G.4 - Molybdopterin Rv0439c - 30.7 29.7 12.7 17.8 32.2 27 37.0377886790083 -0.121654973246937 0.419335483049487 -0.290113711251523 0.771729246615648 0.962399953173527 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0440 groEL2 326.8 163.1 173 279.7 336.4 168.4 617.083485150426 0.0576278448208583 0.21448293745997 0.268682653750085 0.788173901397659 0.963989543249515 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A) III.B - Chaperones/Heat shock Rv0441c - 55.4 32 20 55.7 42.4 26.4 25.0582902085202 0.0848453038918947 0.449992821562371 0.188548127495262 0.850446991699756 NA Hypothetical protein II.C.5 - Other membrane proteins Rv0442c PPE10 33 20.7 21.7 24.8 19 14.7 52.8010708419665 -0.552335804214811 0.337412541335877 -1.63697473137191 0.101635749473332 0.628913832311492 PPE family protein PPE10 IV.C.2 - PPE family Rv0443 - 169.7 97.2 85.4 101 141.1 111.3 96.6123621116924 -0.199852628560581 0.278506217367629 -0.717587673444197 0.473011560273987 0.904373078832156 hypothetical protein VI - Unknowns Rv0444c rskA 144.9 114.4 67 171.9 123.6 84.8 129.103674975731 0.0629645952719291 0.265006467999631 0.237596447163006 0.812194106371652 0.966073477417693 Anti-sigma factor RskA (regulator of sigma K) V - Conserved hypotheticals Rv0445c sigK 73.5 53.6 43.9 108.8 90.4 61.8 63.8347362539175 0.445148250931048 0.308996464664487 1.44062570882291 0.149690453311411 0.695223866622759 Alternative RNA polymerase sigma factor SigK II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0446c - 54.7 32.4 21.9 60.5 46.2 39.8 51.1314489665752 0.29144857811861 0.330068917423108 0.882993104573394 0.377239997102956 0.891834044433142 Possible conserved transmembrane protein V - Conserved hypotheticals Rv0447c ufaA1 27.5 15.6 11 20.1 21.8 21 38.9908626927906 0.0148442165339323 0.368731245341302 0.0402575499675714 0.967887796541877 0.998153412295216 Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) I.H.2 - Modification of fatty and mycolic acids Rv0448c - 5.3 2.6 5.4 7.1 16.3 0 5.7840390593213 0.658115975492539 0.941177321791515 0.699247591558864 0.484397313154908 NA hypothetical protein V - Conserved hypotheticals Rv0449c - 17.5 16.7 8.8 15.6 22.2 18.4 34.8149846348835 0.185047733361167 0.406516801698425 0.455203161561928 0.648963086210414 0.939577115195416 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0450c mmpL4 83 68.4 51.1 63.4 85.7 81.1 342.123725657149 -0.0114036493956846 0.236352213138463 -0.0482485407868976 0.961518165253413 0.998153412295216 Probable conserved transmembrane transport protein MmpL4 II.C.4 - Conserved membrane proteins Rv0451c mmpS4 120.5 114.8 77.8 45.8 115.4 85.8 65.3807361716636 -0.586208989966102 0.383153067868858 -1.52996031906169 0.126026551273351 0.671582561030228 Probable conserved membrane protein MmpS4 II.C.4 - Conserved membrane proteins Rv0452 - 4.6 4.9 4.5 10.8 8 8 7.50369239208805 0.790188672991584 0.778391099848622 1.0151563566763 0.310031300869972 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0453 PPE11 2.8 1.1 0.7 1.4 0 3.6 3.41125046744492 0.0212052350625307 1.23074721305282 0.0172295617147342 0.986253478848775 NA PPE family protein PPE11 IV.C.2 - PPE family Rv0454 - 3.7 0 0.3 3.4 0 0 0.469552233962478 0.0256115706168123 3.03394674378687 0.00844166782731487 0.993264603569283 NA hypothetical protein V - Conserved hypotheticals Rv0455c - 825.8 891.6 625 276.4 1108.6 1095.9 607.338111377941 -0.103674989982676 0.692166631135479 -0.14978328240499 0.880935599261055 0.980703859230131 hypothetical protein VI - Unknowns Rv0456c echA2 9.6 9.2 4.8 5.9 16.2 6.3 12.1360813619793 0.0593568891338058 0.653411357423397 0.0908415326110467 0.927618508210903 NA enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0456A mazF1 32 12.2 1.6 33.9 21.2 27.6 8.19735742042921 0.782751439903789 0.826068612239881 0.947562258516713 0.343352347376987 NA Possible toxin MazF1 ? Rv0456B mazE1 34.1 1 4.3 22.7 34.1 24.4 4.57160158924246 0.769767909572487 1.0628862113036 0.724224193884673 0.468928107578522 NA Possible antitoxin MazE1 ? Rv0457c - 17 6.8 9.8 10.9 13.7 12.6 38.0692675289702 -0.0618362523849921 0.390320288547231 -0.158424386841755 0.874122398510942 0.979668782123689 Probable peptidase II.B.3 - Proteins, peptides and glycopeptides Rv0458 - 79.5 53.5 41.1 43.9 54.8 42 128.841852430333 -0.501687706836705 0.249713974436331 -2.00904938527827 0.0445318966198793 0.424742158795125 Probable aldehyde dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0459 - 55.3 23.9 25.3 45.4 48.1 21.6 27.5914168588629 -0.0166107622227191 0.43240432715692 -0.038414884355889 0.969356893741745 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv0460 - 67.9 41.3 16.5 97.8 75.4 56.8 21.2988882912107 0.778710477994985 0.488278635798481 1.59480759734974 0.110755267607507 NA Conserved hydrophobic protein V - Conserved hypotheticals Rv0461 - 38.8 20 11.1 49.4 21.5 29.8 22.6955824610505 0.423499684778222 0.489423777811264 0.865302635421886 0.386872704718267 NA Probable transmembrane protein II.C.5 - Other membrane proteins Rv0462 lpdC 179.3 113.6 74.6 174.6 167.5 110 298.391190830049 0.146733073555346 0.203366242878599 0.721521288284503 0.470588847675732 0.902597484602108 Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) I.B.2 - Pyruvate dehydrogenase Rv0463 - 56 31.7 35.4 68.6 64.3 27 21.4298203946628 0.185588726315457 0.484806578910235 0.382809834661547 0.701860768950701 NA Probable conserved membrane protein V - Conserved hypotheticals Rv0464c - 158.8 119.9 63.1 124.2 178.4 186.2 126.399611077591 0.361812315719037 0.291355321455471 1.24182497821422 0.21430114469803 0.773070552038584 hypothetical protein V - Conserved hypotheticals Rv0465c - 59.8 32 31.4 31.8 75 33.7 99.3424071437967 -0.00699269577024779 0.329629222601885 -0.0212138223518287 0.983075088121844 0.998667985896356 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0466 - 97 56.2 45.4 146 102.2 75.5 107.277108873755 0.551431742131611 0.266346842324139 2.07035209173056 0.0384193847428177 0.402530371964521 hypothetical protein V - Conserved hypotheticals Rv0467 icl1 74.5 96.1 42.2 62.5 64.7 38.1 132.73792353565 -0.574303139092933 0.303737746780355 -1.8907861969103 0.0586528904833769 0.499013258722963 Isocitrate lyase Icl (isocitrase) (isocitratase) I.B.4 - Glyoxylate bypass Rv0468 fadB2 33.3 37.2 8.6 38 18.6 24.2 35.6090691600139 -0.0486822959489011 0.452403026900801 -0.107608245423114 0.914306456073606 0.9932884147079 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) I.A.3 - Fatty acids Rv0469 umaA 276.1 261.4 204.4 206.2 334.3 391.8 399.587499365588 0.124312326539816 0.289358534140012 0.429613479033126 0.667476830415619 0.940354944889996 Possible mycolic acid synthase UmaA I.H.2 - Modification of fatty and mycolic acids Rv0470c pcaA 401.6 290.8 217.5 303.7 347.1 320.9 438.526314947769 -0.085516983975879 0.202091352658439 -0.423160035552901 0.672178502722506 0.940710721884994 Mycolic acid synthase PcaA (cyclopropane synthase) I.H.2 - Modification of fatty and mycolic acids Rv0470A - 48.9 27.7 22.9 33.6 43.8 27.4 23.1749278367141 -0.0941164291405314 0.457070894606558 -0.205912103026262 0.836859571187605 NA Hypothetical protein ? Rv0471c - 105 48.7 55 55.1 56.8 43 47.2031879109955 -0.617580662280001 0.345752831856333 -1.78619119029115 0.0740683070179849 0.54162997700187 Hypothetical protein VI - Unknowns Rv0472c - 336.2 211.9 141.6 241.2 279.7 197.1 261.409201956428 -0.100808280332644 0.20878114077671 -0.48284188867642 0.629208005660781 0.93413540068838 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0473 - 87.3 56.9 53.1 89.2 70.5 63.7 154.435279209249 -0.00938825713600034 0.234692140659538 -0.0400024351459628 0.968091184882817 0.998153412295216 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0474 - 172.8 84.8 111.3 104.1 99.6 130.1 80.8841309227874 -0.366580280817711 0.312138909599383 -1.17441392131536 0.240229271826273 0.78958848015113 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0475 hbhA 465.9 252.9 226.4 571.8 429.6 294.6 350.107690224763 0.287747696403868 0.208726920215184 1.37858449742476 0.168022899026495 0.725041090026968 Iron-regulated heparin binding hemagglutinin HbhA (adhesin) II.C.5 - Other membrane proteins Rv0476 - 629.4 346.1 203.7 644.5 472.1 346.5 178.453657471483 0.19262308219039 0.248666720506099 0.774623487205503 0.438562174484467 0.901158530199572 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0477 - 255.3 186.8 109.7 163.2 183 83.4 115.377011313923 -0.525456195295131 0.273448972833999 -1.92158774578435 0.0546576517432947 0.485439307271885 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0478 deoC 124 51.6 60.6 119 51.9 49.7 79.7553798647028 -0.240751737954207 0.33956438978449 -0.709001724553637 0.478323406651583 0.907292899730371 Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase) I.F.4 - Salvage of nucleosides and nucleotides Rv0479c - 91 59.5 62.1 60.8 92.4 103.1 134.434441321317 0.0499571661423342 0.300481156045815 0.166257234895346 0.867954519201521 0.977876220223739 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0480c - 44.4 24.8 11.5 31.9 44.4 37.7 41.8823194612203 0.330492636887626 0.385302482197085 0.857748527865898 0.391031337379359 0.893826103932853 Possible amidohydrolase V - Conserved hypotheticals Rv0481c - 56.6 42.4 35.6 44 51.2 52.1 40.0549961838984 -0.0888511499658721 0.375944680209101 -0.236341022079241 0.813168057378265 0.966389401486634 Hypothetical protein VI - Unknowns Rv0482 murB 17.1 9.4 7.4 20.8 14.6 19.6 25.1282399645131 0.50952520093234 0.444271604358874 1.14687771159184 0.251432165543248 NA Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) II.C.3 - Murein sacculus and peptidoglycan Rv0483 lprQ 619.6 286 249.7 338.9 339 308.8 764.840819741028 -0.348173511651393 0.187204214896206 -1.85985936184415 0.0629054261611027 0.514454587842348 Probable conserved lipoprotein LprQ V - Conserved hypotheticals Rv0484c - 42.3 21.2 21.4 31.8 31.9 14.8 31.7873571033591 -0.290859570205394 0.407694326082005 -0.713425602462 0.475582435005016 0.90542768727261 Probable short-chain type oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0485 - 320.4 154.4 142.4 237.9 183.7 169.5 418.771428470511 -0.206594595400388 0.194906495995513 -1.05996772629448 0.289159282154831 0.83054472942914 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0486 mshA 275.5 159.4 139.2 212.7 139.9 119.1 401.964972088543 -0.45243226143572 0.205570601226903 -2.20086072004205 0.0277458854300721 0.352041830732016 Glycosyltransferase MshA V - Conserved hypotheticals Rv0487 - 185.2 96.2 85.1 198.5 132.5 143.7 121.576419245667 0.217913469770563 0.254263312122075 0.857038587092503 0.391423559508154 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv0488 - 13.9 3.6 4.5 5.9 10.4 0 5.43099598020733 -0.649355756855249 0.939552855634058 -0.691132758483322 0.489482115562183 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0489 gpm1 151.9 94.2 60.3 116.1 123 100.3 127.256601132607 -0.00448314803999774 0.245395174920988 -0.0182690961280768 0.985424181068007 0.999019127881181 Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) I.B.1 - Glycolysis Rv0490 senX3 350.2 229.3 234.5 297.1 271.5 231.8 540.820075333433 -0.237153101963037 0.194809868873858 -1.21735671469805 0.223468524434393 0.774556499980442 Putative two component sensor histidine kinase SenX3 I.J.2 - Two component systems Rv0491 regX3 150.2 93 102.6 190 104.1 123.7 139.927408161371 0.0689349491784383 0.272196883260065 0.253253998917305 0.80007194108766 0.965592404376002 Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) I.J.2 - Two component systems Rv0492c - 14.5 10.9 1.9 10 13.4 9 28.525924589485 0.149772024785892 0.488678623499518 0.30648368392574 0.75923640086009 0.959593750764785 Probable oxidoreductase GMC-type I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0492A - 4.2 4.8 6.9 6.3 0 0 1.81035879206799 -0.983919117985919 1.63223242742701 -0.602805765559339 0.546637910789464 NA Hypothetical protein ? Rv0493c - 7.9 8.9 6.4 7.4 3.7 2.9 9.49725236192779 -0.872267463130804 0.731126088655914 -1.19304655744724 0.232851139862959 NA hypothetical protein V - Conserved hypotheticals Rv0494 - 0.5 0 0 0.8 0 0 0.14158381662874 0.24793604593808 4.00122835019534 0.0619649828098352 0.950590718060154 NA Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0495c - 204.5 133 145.4 134.8 145.1 141.3 221.545476590501 -0.420179816408659 0.239156110200162 -1.75692695477021 0.0789302605272832 0.55131591065269 hypothetical protein V - Conserved hypotheticals Rv0496 - 108.6 51.3 46.6 121.2 100.5 75 128.23996363521 0.368637772141869 0.247625219195138 1.48869236073797 0.136568397567029 0.682181933169668 hypothetical protein V - Conserved hypotheticals Rv0497 - 98.5 73.3 44.1 94.6 75.2 69 111.788096638859 -0.0110666645157948 0.256980137791699 -0.0430642796400288 0.965650293587119 0.998153412295216 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0498 - 47.4 29.1 31.8 62.7 35.3 20.8 50.0432176236239 -0.0289981809620645 0.375117682066337 -0.0773042230436271 0.938381531459864 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv0499 - 35.5 33.9 21.1 61.1 25.3 22.8 45.6519632248769 0.136547894473614 0.400924952741274 0.340582180131182 0.733418146432487 0.951963675754228 hypothetical protein VI - Unknowns Rv0500 proC 89 67.2 47.3 83 70 50.3 96.0730480261192 -0.161888673174073 0.268065875435127 -0.603913768999109 0.545900974028693 0.92521033104044 Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase) I.D.1 - Glutamate family Rv0500A - 252 159.8 106.1 326.8 265 192 79.3601208203492 0.451032688182848 0.284281293322115 1.58657181734357 0.112609654596398 0.648445531184945 hypothetical protein ? Rv0500B - 496.5 313.1 176.7 520.2 499.8 221.8 57.9525460505221 0.215712778311324 0.334613379101125 0.64466274149227 0.519145766264214 0.915911629458156 hypothetical protein ? Rv0501 galE2 228.4 115.5 134.7 139.6 210.3 130.5 290.351691662184 -0.191807403763084 0.238800555296938 -0.803211715837846 0.421852374979612 0.901158530199572 Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.A.1 - Carbon compounds Rv0502 - 317.9 161.6 163.2 255.9 307.8 242.7 413.551774391613 0.158622359754677 0.201534679218407 0.787072281405101 0.431239554503512 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0503c cmaA2 191.1 186.8 114.6 144.4 206.4 258.1 275.30545671676 0.125414166856669 0.288857378888249 0.434173318816924 0.664162586637525 0.939759692320761 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) I.H.2 - Modification of fatty and mycolic acids Rv0504c - 63.9 52.6 43 57.5 92.4 103.3 55.7845188095872 0.441414944768381 0.371621287233378 1.18780855654044 0.234908842548235 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv0505c serB1 108.1 62.6 48.1 79.4 57.6 57.9 122.465257359061 -0.309588122781925 0.248414169641953 -1.24625790561039 0.21266972646399 0.773070552038584 Possible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase) I.D.3 - Serine family Rv0506 mmpS2 51 27.7 26 66.7 84.2 70.3 37.093082909816 0.908892407202681 0.381868449773534 2.38011914244735 0.0173070412976164 0.276757764055105 Probable conserved membrane protein MmpS2 II.C.4 - Conserved membrane proteins Rv0507 mmpL2 62.9 55.6 29.9 54.3 59.4 62.2 253.626127084283 0.0737894208686521 0.241644623672535 0.305363387553153 0.760089403415058 0.959593750764785 Probable conserved transmembrane transport protein MmpL2 II.C.4 - Conserved membrane proteins Rv0508 - 152.5 81.1 76.1 174.7 108.8 35.1 47.2979051743504 -0.0931956210183903 0.396251898761638 -0.235192869257268 0.814059040297852 0.966389401486634 hypothetical protein VI - Unknowns Rv0509 hemA 581.9 287.8 318.6 471 358.6 283 861.116976390564 -0.276988474392338 0.19341625003195 -1.43208481369369 0.152119550057278 0.700104285288568 Probable glutamyl-tRNA reductase HemA (GLUTR) I.G.12 - Heme and porphyrin Rv0510 hemC 1005.5 555.9 587.8 1202.7 595.8 596.5 1120.40623032148 -0.0507222193268233 0.231682003587858 -0.218930337882668 0.826704313471018 0.967727711626973 Probable porphobilinogen deaminase HemC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase) I.G.12 - Heme and porphyrin Rv0511 hemD 566.1 293.7 266.8 581.7 377.7 272.2 1046.20062395661 -0.0448930990626871 0.206588030819432 -0.217307357471865 0.827968823661101 0.968638603196576 Probable uroporphyrin-III C-methyltransferase HemD (uroporphyrinogen III methylase) (urogen III methylase) (SUMT) (urogen III methylase) (UROM) I.D.3 - Serine family Rv0512 hemB 540 342.6 255.4 480.8 369.9 295.9 598.446285139897 -0.156610300238233 0.181874216602326 -0.861091270461202 0.389187776705491 0.893826103932853 Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) I.G.12 - Heme and porphyrin Rv0513 - 451 281 186.2 524.7 280.6 309.3 291.269588742129 0.13453083473605 0.235504757190176 0.571244659093716 0.567833809376135 0.92521033104044 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0514 - 191.3 84.9 59.5 226.2 127.9 98.8 59.1614281084236 0.334303317720711 0.352842122445639 0.947458640718883 0.343405121961983 0.856500060727542 Possible transmembrane protein II.C.5 - Other membrane proteins Rv0515 - 132 86.7 86.2 221.4 144.2 140.7 324.573120850652 0.527436007959113 0.220525971384699 2.39171832980625 0.0167697066045595 0.276757764055105 Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0516c - 226.6 198.6 105.9 389.7 474 380.5 221.754667034905 1.06904253719586 0.238003224626774 4.49171450879409 7.0652091008638e-06 0.000888289471499512 Possible anti-anti-sigma factor V - Conserved hypotheticals Rv0517 - 21.1 9.8 8 23.7 29.5 20.1 37.178043939663 0.730135717710453 0.381757830952029 1.91256251611038 0.0558040821839018 0.489697086350399 Possible membrane acyltransferase IV.H - Miscellaneous transferases Rv0518 - 30 18.2 7.5 19.8 12.9 15 18.3894078624692 -0.329746246242401 0.523384937670929 -0.630026243609105 0.52867741407335 NA Possible exported protein VI - Unknowns Rv0519c - 29.5 33.6 10.4 47.5 36.7 30.9 44.0200580750723 0.531063017109973 0.389044204253244 1.36504544034868 0.17223876851092 0.729574936755292 Possible conserved membrane protein V - Conserved hypotheticals Rv0520 - 9.2 7.2 2.1 8.4 8.5 0 2.68872234304752 -0.264540691431863 1.26554012246014 -0.209033824164824 0.834421833967631 NA Possible methyltransferase/methylase (fragment) IV.H - Miscellaneous transferases Rv0521 - 4 3.8 3.3 3.3 3.2 0 1.04313595252394 -1.08152524610899 2.00275270729243 -0.540019365431856 0.589183677402207 NA Possible methyltransferase/methylase (fragment) ? Rv0522 gabP 30.7 38.4 10.1 40.5 27 36.7 63.4115385904862 0.266033229189063 0.380524063200627 0.699123274758055 0.484474994230072 0.908019273666837 Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease) III.A.1 - Amino acids Rv0523c - 35.6 16.2 13 28.1 32.4 17.4 14.2529843703266 0.0845285242447842 0.566319634276874 0.149259391920461 0.881348956822466 NA hypothetical protein V - Conserved hypotheticals Rv0524 hemL 299.3 158.6 142.3 230.2 195.7 138.2 426.683082119671 -0.248652487538432 0.191165490245011 -1.30071848857104 0.193354831411313 0.744873904851938 Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) I.G.12 - Heme and porphyrin Rv0525 - 261 117.4 87.6 193.2 150.4 113.8 144.337855600385 -0.148999404599504 0.255014142098016 -0.584278986936478 0.559032627206915 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv0526 - 265.4 182.2 158.9 285.6 170.3 264.5 233.193708401107 0.0673230069575883 0.248163482183897 0.271284906083401 0.786171914538281 0.963989543249515 Possible thioredoxin protein (thiol-disulfide interchange protein) V - Conserved hypotheticals Rv0527 ccdA 164.4 80.5 74.3 214.4 99.9 68.4 140.461920632296 0.10909952086251 0.307486949449166 0.354810248233142 0.722731750289593 0.949890877982223 Possible cytochrome C-type biogenesis protein CcdA I.B.6.a - aerobic Rv0528 - 175 89.7 124.8 153.1 144.8 120.9 347.693162442012 -0.112561204490986 0.228747890378075 -0.492075377416357 0.622666057957874 0.931582271037618 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0529 ccsA 170.3 104.2 106.3 159 143.8 88.2 201.010292614253 -0.16337066176651 0.231015539301341 -0.707184729912937 0.4794516867195 0.907292899730371 Possible cytochrome C-type biogenesis protein CcsA I.B.6.a - aerobic Rv0530 - 144.4 79.6 52.6 117.4 122 88.4 191.077542618201 0.112156489113175 0.224924181395911 0.498641312895377 0.618032095431687 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv0530A - 187.8 174.8 94.8 212.7 159.7 173.9 42.8966061796119 0.103024314958807 0.364533342957665 0.28261972998934 0.777468354342206 0.963013023606306 hypothetical protein ? Rv0531 - 133.8 87.4 47.9 209.4 113.6 35.5 49.4783680146016 0.302549337424422 0.423178110141142 0.714945622597334 0.47464264456308 0.905192593210816 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0532 PE_PGRS6 14.3 6.4 6.8 23.6 2.7 16.4 32.4724221616395 0.510129280870651 0.526325021901727 0.969228631820395 0.332431128529881 0.853347384539607 PE-PGRS family protein PE_PGRS6 IV.C.1.b - PE_PGRS subfamily Rv0533c fabH 49.4 26.4 20.8 45.6 47.9 41.7 60.3634476702888 0.312955200733288 0.310098251036026 1.00921304679313 0.312872470888819 0.846061021823653 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) I.H.1 - Synthesis of fatty and mycolic acids Rv0534c menA 12.3 6.1 10.5 20.7 8.4 9.7 15.5853059039826 0.23713790140866 0.582812527115428 0.406885388312345 0.684092168185425 NA 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0535 pnp 20.8 10.1 5.4 12.8 7.2 11.4 13.2360780831057 -0.313497705512199 0.609407596607165 -0.514430255312826 0.606951210749307 NA Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv0536 galE3 12.3 9.5 5.4 21.6 18.5 13.7 21.1706623842721 0.882317831702935 0.475521935483392 1.85547241013396 0.0635287955323618 NA Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.A.1 - Carbon compounds Rv0537c - 66.8 41 25.7 72.9 61.3 50 118.164496902832 0.331584743886484 0.250215283165426 1.32519780443332 0.18510555339738 0.739746500217031 Probable integral membrane protein II.C.5 - Other membrane proteins Rv0538 - 33.1 23.3 25.1 26.3 31.2 14.9 68.7991507443309 -0.396997559011735 0.322652195887776 -1.23041951696438 0.218540048511961 0.773070552038584 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0539 - 31.8 16.6 21.2 30.4 29.8 43.5 29.4473860236393 0.359212107865705 0.43456362506689 0.826604177490496 0.408461448808912 0.901158530199572 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) IV.H - Miscellaneous transferases Rv0540 - 12.7 0.6 3.9 21.3 24.2 17.4 12.585394790464 1.5888583435764 0.680645938953033 2.33433897515113 0.0195779794381045 NA hypothetical protein V - Conserved hypotheticals Rv0541c - 81.2 54.8 37.4 114 110.2 63 161.134588590877 0.57247530224858 0.236391862040287 2.42172170102462 0.0154471753510136 0.27042333557534 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0542c menE 152.7 79.8 70.1 176.2 148.7 110.2 208.875071932443 0.366781179167112 0.215063649724712 1.70545408132245 0.0881097693231125 0.571985071522678 Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0543c - 265.1 155.4 123.5 320.1 223.5 138.1 96.079457934348 0.180005383072866 0.28432727484011 0.633092210988519 0.526673428420287 0.921428654655606 hypothetical protein V - Conserved hypotheticals Rv0544c - 166.7 130.7 82.4 138 151.4 123.7 58.8494261107944 -0.0476510873536743 0.316781545061099 -0.150422548587809 0.880431252465806 0.980703859230131 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0545c pitA 392.1 293.5 200.5 407.8 345.4 230.9 621.676822428917 -0.038804391853507 0.192139242922753 -0.20195974160837 0.83994819715398 0.973720332492836 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA III.A.4 - Anions Rv0546c - 81.7 82.7 31.4 88 71.8 71.7 43.2828009710735 0.131914550421013 0.375145085033027 0.351636088766563 0.725111196649909 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv0547c - 40.2 19.9 9 30.8 23.1 17 30.7362634822697 -0.07683646508665 0.436224296808894 -0.176139810754997 0.860184105375266 0.976194404037999 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0548c menB 120.9 71.8 63.1 85.2 103 51.4 123.545070688144 -0.276484464032783 0.256931592851785 -1.07610146718032 0.281881879578515 0.825259204787765 Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0549c vapC3 42.3 21.3 27.7 52.1 35.4 30.3 22.3761445899566 0.220031522575965 0.469995114915675 0.468157041622534 0.639672290053179 NA Possible toxin VapC3 V - Conserved hypotheticals Rv0550c vapB3 24.1 4 4.7 41.4 9.9 21.8 6.35810810166614 1.07870333425515 0.929668720340554 1.1603093775813 0.245922867856817 NA Possible antitoxin VapB3 VI - Unknowns Rv0551c fadD8 22 15.1 8.7 18.6 21.5 10.7 42.7803442768314 -0.0114611148464759 0.362856699295472 -0.0315857881878134 0.974802377119007 0.998153412295216 Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0552 - 29.1 13.2 17.3 23 19.6 14.7 49.3413825002124 -0.254564131342606 0.345209110168352 -0.737420084940574 0.4608669250231 0.901158530199572 hypothetical protein I.J.1 - Repressors/activators Rv0553 menC 13.8 4.1 8.9 16.6 13.2 11.7 16.6416875079585 0.428428104595684 0.548669807999277 0.780848696883733 0.43489148901908 NA Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0554 bpoC 51.5 28.9 22.7 53.8 46.7 47.6 51.7551469080421 0.360262394171173 0.327084452941454 1.10143539667309 0.270707207007403 0.812783093966197 Possible peroxidase BpoC (non-haem peroxidase) III.F - Detoxification Rv0555 menD 178 80.9 68.1 168.9 113 120.3 314.788106521578 0.172917185111663 0.219652897400992 0.787229247406605 0.431147678974545 0.901158530199572 Probable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0556 - 173.9 161 97.3 169.2 190.7 149.2 130.482795435719 0.042033550288108 0.259708357809941 0.161849047302778 0.871424728022711 0.977891032682394 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0557 mgtA 100.5 72 46.9 81.2 76.9 48.8 127.921266362168 -0.246963350899942 0.247735733295233 -0.996882232591089 0.318821676806778 0.849576838196095 Mannosyltransferase MgtA V - Conserved hypotheticals Rv0558 menH 216.1 139.3 88.9 196.2 158.2 137.1 172.593319619405 -0.000892131177436641 0.226042423229484 -0.00394674222958107 0.996850963484856 0.999833281786427 Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0559c - 916.9 702.8 393.3 447.5 1211.4 756.6 401.128401716251 0.116323493729628 0.302753759946824 0.384218163797731 0.70081675685535 0.947279830180307 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0560c - 42.6 31.7 34.9 41.9 29.3 30.4 42.0028838475992 -0.304891147018957 0.377328449796695 -0.80802586495461 0.41907569265882 0.901158530199572 Possible benzoquinone methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0561c - 23.7 14.1 11.4 25.2 15.6 12.7 32.5282975979154 0.0156362072283937 0.402758327785591 0.0388228030302024 0.969031664348162 0.998153412295216 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0562 grcC1 139.3 78.4 58.8 144.1 118.7 86.6 163.832909525122 0.188457819807022 0.229295916176957 0.82189784689223 0.411135038502923 0.901158530199572 Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0563 htpX 105.1 48.8 66.7 92.1 93 81.2 111.989121979414 0.068703284042602 0.270540930957766 0.253947836282589 0.79953585781687 0.965592404376002 Probable protease transmembrane protein heat shock protein HtpX III.B - Chaperones/Heat shock Rv0564c gpdA1 23.2 10.8 5.8 9.7 13.3 12.5 19.3207096836125 -0.347349814115179 0.521854777390668 -0.665606274320159 0.505662794928604 NA Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0565c - 14.7 9.3 9.5 10.8 18.6 6.8 26.4503726625313 -0.132014449453715 0.456310869291154 -0.289308141308994 0.772345582722184 NA Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0566c - 26.3 11.4 13.3 21.2 39.2 28.3 17.6963748532837 0.566956681374866 0.537959502252767 1.05390215992221 0.291927713924263 NA hypothetical protein V - Conserved hypotheticals Rv0567 - 64.1 27.8 25.5 50.7 46.4 88.9 81.8353756578155 0.522141035014708 0.348333053298844 1.49897068357377 0.133881237608308 0.680441181456551 Probable methyltransferase/methylase IV.H - Miscellaneous transferases Rv0568 cyp135B1 249.2 122.4 148.4 205 139.4 125.2 375.741854567989 -0.337009603105547 0.221785528275582 -1.51952927553863 0.12862932480487 0.671582561030228 Possible cytochrome P450 135B1 Cyp135B1 IV.F - Cytochrome P450 enzymes Rv0569 - 613.3 294.1 686.5 174.4 88.6 99.7 154.824756320394 -2.42572469771794 0.36975619630828 -6.5603354911611 5.36868533724531e-11 1.85622295535256e-08 hypothetical protein V - Conserved hypotheticals Rv0570 nrdZ 185.8 63.3 147.7 49 21.9 21.8 289.390942434765 -2.35059753966831 0.54187974502987 -4.33785828170924 1.43877874249814e-05 0.0014213078577678 Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0571c - 61 11.3 35.9 29.2 7.2 15.8 56.7685594302852 -1.22628089515885 0.771978877511864 -1.58849021764848 0.112175531355959 0.648445531184945 hypothetical protein V - Conserved hypotheticals Rv0572c - 84.4 45.4 64.8 18 6.4 15 22.9101304864273 -2.49514097983157 0.552621001971478 -4.51510342699634 6.32858716029043e-06 NA Hypothetical protein VI - Unknowns Rv0573c pncB2 18.5 5.1 13.5 5.4 4 4.2 19.0853214454557 -1.69823419220292 0.579304840275472 -2.93150354379117 0.00337325517588598 NA Nicotinic acid phosphoribosyltransferase PncB2 V - Conserved hypotheticals Rv0574c - 87.9 38.1 62.6 19.1 11.9 8.8 73.2058268534315 -2.43921929935175 0.373425713118776 -6.53200680526222 6.48942063173693e-11 1.99441527415382e-08 hypothetical protein V - Conserved hypotheticals Rv0575c - 19.9 8.9 6.9 10 6.3 2.4 15.7216636313753 -1.04131679660503 0.592627222276337 -1.75711941244486 0.0788974575371336 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0576 - 74.7 42.8 34.7 62.8 69.2 39.8 110.604970378318 0.00747415443396524 0.256138618996986 0.0291801152955119 0.976720940175732 0.998153412295216 Probable transcriptional regulatory protein (possibly ArsR-family) I.J.1 - Repressors/activators Rv0577 TB27.3 101 62.5 46.6 83.4 67.8 62.3 87.5266219298255 -0.133584272941467 0.269837357542968 -0.495054777284481 0.620561454604873 0.931582271037618 Conserved protein TB27.3 V - Conserved hypotheticals Rv0578c PE_PGRS7 136.2 75.9 85.3 158.5 74.9 91.1 652.580549398224 -0.0800011076119366 0.243240515993269 -0.328897130008351 0.742233443670082 0.955781054558401 PE-PGRS family protein PE_PGRS7 IV.C.1.b - PE_PGRS subfamily Rv0579 - 101.2 72.2 32.7 68.6 62.6 57.6 78.1538215366509 -0.275208394275565 0.301812837991111 -0.911851186011083 0.361847060952371 0.882600503169541 hypothetical protein V - Conserved hypotheticals Rv0580c - 70.5 57.3 27.6 65.3 56.2 40.2 40.4211346234324 -0.0991216258948054 0.370745280607305 -0.267357754985951 0.789193722494427 0.963989543249515 hypothetical protein VI - Unknowns Rv0581 vapB26 109.8 64.9 15.6 87.9 74.9 61 21.804051360038 0.131032576302535 0.512917549526729 0.255465184264876 0.798363830595891 NA Possible antitoxin VapB26 V - Conserved hypotheticals Rv0582 vapC26 37.2 38 20.9 29.8 26.9 45.9 22.0267546434649 -0.152047478895933 0.503433886256686 -0.302020748000282 0.762636246455662 NA Possible toxin VapC26 Contains PIN domain VI - Unknowns Rv0583c lpqN 9 11 9.4 5.8 13.2 1.6 9.17549016192384 -0.832177123072046 0.776639537890778 -1.07151011823593 0.283940123615638 NA Probable conserved lipoprotein LpqN II.C.1 - Lipoproteins(lppA-lpr0) Rv0584 - 11.7 9.3 7 9.9 12.7 9.8 42.4579396133356 0.0211221494136044 0.363349602454594 0.0581317531955851 0.953643681758698 0.998153412295216 Possible conserved exported protein VI - Unknowns Rv0585c - 7.2 2.9 3.6 9.5 8.1 5.9 22.4174060863262 0.614366850101575 0.46747126472735 1.31423447056131 0.18876731169217 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0586 mce2R 100.2 51 55.7 122.7 116.1 58.6 94.1133804321338 0.342607358164446 0.285095012230577 1.2017304528897 0.229467978436122 0.784559243948471 Probable transcriptional regulatory protein Mce2R (GntR-family) I.J.1 - Repressors/activators Rv0587 yrbE2A 95.9 67.4 52.3 113.4 116.7 83.7 111.508593541514 0.367651729684899 0.25164693436737 1.46098235056652 0.144020285060907 0.690135194188255 Conserved hypothetical integral membrane protein YrbE2A IV.A - Virulence Rv0588 yrbE2B 67.7 66.4 38.3 64 73.3 46.8 84.7904491014588 -0.0937077543608141 0.296853037535872 -0.315670525518845 0.752252600818737 0.959593750764785 Conserved hypothetical integral membrane protein YrbE2B IV.A - Virulence Rv0589 mce2A 64.5 69.3 45 59.2 62.4 69.7 123.414206904398 -0.124760016032497 0.28865013289052 -0.432218806841208 0.665582391777906 0.940245605545295 Mce-family protein Mce2A IV.A - Virulence Rv0590 mce2B 62.5 85.1 27.2 46.1 65.5 77.6 82.1425190527617 -0.0844073385395707 0.376394361978777 -0.224252398723045 0.82256091324149 0.967727711626973 Mce-family protein Mce2B IV.A - Virulence Rv0590A - 35.1 40.9 8.2 33.5 44.2 20.7 11.9351288915058 0.114790994859388 0.653873117729022 0.175555458309819 0.860643197887332 NA Mce-family related protein ? Rv0591 mce2C 10.1 9.7 2.7 7.8 6 15.7 19.6719680195177 0.198636001015637 0.565230146270418 0.351424994449262 0.725269533831509 NA Mce-family protein Mce2C IV.A - Virulence Rv0592 mce2D 6.8 3.7 3.7 10 9.7 9.3 16.6526101023883 0.863313472473821 0.527472945382291 1.63669716149731 0.101693762373171 NA Mce-family protein Mce2D IV.A - Virulence Rv0593 lprL 12.2 3 8.1 10.5 9.2 16.4 18.8534903527097 0.364436045688895 0.548974536482649 0.663848724248458 0.506787137052629 NA Possible Mce-family lipoprotein LprL (Mce-family lipoprotein Mce2E) II.C.1 - Lipoproteins(lppA-lpr0) Rv0594 mce2F 14.4 12.7 7.2 13.8 23.2 11 33.5324825498035 0.30721453161997 0.414626264433379 0.740943249313461 0.458727850649867 0.901158530199572 Mce-family protein Mce2F IV.A - Virulence Rv0595c vapC4 37.7 28.6 19.5 27.1 105 35.4 25.4413284959919 0.819245575453101 0.532237126179638 1.53924920896366 0.123743468371113 NA Possible toxin VapC4 V - Conserved hypotheticals Rv0596c vapB4 38.5 22.1 30.9 21.2 46.7 44.9 13.634445008234 -0.0805604057814378 0.621556180306576 -0.129610819317575 0.896874342880394 NA Possible antitoxin VapB4 V - Conserved hypotheticals Rv0597c - 123.2 61.6 53.4 104 97.1 34 150.631809061322 -0.171996072512717 0.285409824554955 -0.602628423113726 0.546755907563216 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv0598c vapC27 186.4 124 84.1 154.9 127.7 135.3 89.1916357483058 -0.0755233941470768 0.272198922085191 -0.277456624620431 0.781429507354102 0.963989543249515 Possible toxin VapC27 Contains PIN domain V - Conserved hypotheticals Rv0599c vapB27 236 121.9 76.9 247.7 171.7 169.6 61.6246173996299 0.31242414660279 0.32178137651634 0.970920536126569 0.331587850871605 0.853347384539607 Possible antitoxin VapB27 V - Conserved hypotheticals Rv0600c - 0 0 0 0.2 0 0.4 0 NA NA NA NA NA Two component sensor kinase [second part] I.J.2 - Two component systems Rv0601c - 0 2.6 0 0 0 0 0.335146847618158 -1.00329576554081 3.8303268782725 -0.261934763644325 0.793371737512884 NA Two component sensor kinase [first part] I.J.2 - Two component systems Rv0602c tcrA 1.8 0 1.4 4.4 0 0 1.25106798054439 0.731302018227569 1.95207037071201 0.374628921784634 0.707936460499859 NA Two component DNA binding transcriptional regulatory protein TcrA I.J.2 - Two component systems Rv0603 - 1.5 0 0 1.5 0 0 0.163984208666869 0.0739124432741338 3.99971752846394 0.0184794157957748 0.985256398577816 NA Possible exported protein VI - Unknowns Rv0604 lpqO 23 14.5 16.6 15.9 22.5 19.5 28.3650152233316 -0.179790167594376 0.436164288540463 -0.412207446409719 0.680187379686999 0.942913432418385 Probable conserved lipoprotein LpqO II.C.1 - Lipoproteins(lppA-lpr0) Rv0605 - 130.3 129.5 52.4 151.2 135.4 118.7 115.412641141227 0.225264950660609 0.283797840488051 0.793751461509425 0.427340134879486 0.901158530199572 Possible resolvase IV.B.1.c - Others Rv0606 - 89.2 67.4 54.3 88.8 98.8 47.4 87.7924381866795 -0.0299067666154598 0.289303606461731 -0.103375021767715 0.917665335663234 0.9932884147079 Possible transposase (fragment) IV.B.1.c - Others Rv0607 - 31.3 13.3 15.7 15.8 16.6 19.4 11.0761706623843 -0.550496198467776 0.645652153835049 -0.852620401245369 0.393869845288685 NA Hypothetical protein VI - Unknowns Rv0608 vapB28 274.3 183.6 136 268.8 220.9 189.9 82.723551099544 0.0356895714822851 0.274778661845337 0.129884799797058 0.896657570414683 0.988109497915144 Possible antitoxin VapB28 V - Conserved hypotheticals Rv0609 vapC28 223 102.2 76.2 229.8 142.7 157.2 95.8727863295055 0.285076682765248 0.288970948836796 0.986523676213048 0.323876202808902 0.853182454256593 Possible toxin VapC28 Contains PIN domain V - Conserved hypotheticals Rv0609A - 226.2 95.8 84.8 202.4 128.6 134.1 51.3258491313166 0.0605078283201321 0.344612946917895 0.175581993831904 0.86062234941346 0.976194404037999 hypothetical protein ? Rv0610c - 43 23 26.7 35.7 21.5 16.2 51.2976934284823 -0.490082244630551 0.355355100520899 -1.37913384080364 0.167853491694575 0.725041090026968 Hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0611c - 235.9 115.7 72.4 160 185.4 71.6 81.974181810478 -0.131065171062323 0.316862253922391 -0.413634535006572 0.679141777340655 0.942913432418385 Hypothetical protein VI - Unknowns Rv0612 - 18.7 4 5.4 14.1 8.1 5.5 8.11176008757383 -0.120202693214843 0.769965238012124 -0.156114441640481 0.87594281515111 NA hypothetical protein VI - Unknowns Rv0613c - 75 40.3 36.9 93.1 52.4 45.8 230.005971202661 0.169021419615411 0.242851756155443 0.695985988700136 0.486437604422484 0.909299509995111 hypothetical protein VI - Unknowns Rv0614 - 0.8 1.7 0 2.8 2 0 1.33226996578543 1.26516895314493 1.81781032910231 0.695985127210553 0.486438143939143 NA hypothetical protein V - Conserved hypotheticals Rv0615 - 76.4 56.7 33.3 123.1 69.6 33 23.8488261137174 0.336886698811972 0.490150314692247 0.687313031765561 0.491885488421554 NA Probable integral membrane protein II.C.5 - Other membrane proteins Rv0616c - 4.5 11.5 0 3.5 0 0 1.37820974426447 -1.93080524131283 1.95200693128796 -0.989138517064003 0.322595374815906 NA Hypothetical protein VI - Unknowns Rv0616A vapB29 332.4 164.4 156.1 199.5 231.4 191.3 76.613983108829 -0.264351095628219 0.289680151731716 -0.912561989656249 0.361472952984873 0.882466185309938 Possible antitoxin VapB29 ? Rv0617 vapC29 222.9 107.1 137.9 153.9 158.2 85.9 92.8778730455472 -0.426600313089743 0.289152304628674 -1.47534813404852 0.140118971815603 0.682617454377878 Possible toxin VapC29 Contains PIN domain V - Conserved hypotheticals Rv0618 galTa 34.5 20.9 11.4 35 14.4 6.3 21.3544915699014 -0.327105460282246 0.543274274648704 -0.602100035923405 0.547107550626866 NA Probable galactose-1-phosphate uridylyltransferase GalTa [first part] I.A.1 - Carbon compounds Rv0619 galTb 3.4 0 1.9 7.7 6.3 0 2.31481414723475 1.34322392913004 1.41924798806923 0.946433562296173 0.34392749375518 NA Probable galactose-1-phosphate uridylyltransferase GalTb [second part] I.A.1 - Carbon compounds Rv0620 galK 1 0 1.3 2.5 0 0 1.31833917842085 0.100705162740067 1.91080332468688 0.0527030497796363 0.957968509032192 NA Probable galactokinase GalK (galactose kinase) I.A.1 - Carbon compounds Rv0621 - 22.4 4.8 5.5 16.6 6.9 0 14.2307889470572 -0.495391294215929 0.703571071253057 -0.704109811299716 0.481364390528746 NA Possible membrane protein II.C.5 - Other membrane proteins Rv0622 - 8.6 5.8 0.2 5.9 8.3 6.1 7.84765743010361 0.369086983004099 0.82774174395433 0.445896302439549 0.655672153301961 NA Possible membrane protein II.C.5 - Other membrane proteins Rv0623 vapB30 185.8 34.8 56.4 213.8 152.2 73.4 44.8029009129376 0.575654258562264 0.431615465867655 1.33372018401856 0.182295577355961 0.736194517318001 Possible antitoxin VapB30 V - Conserved hypotheticals Rv0624 vapC30 190.7 120.7 85.9 156.5 175 156.5 92.3628869510196 0.12204014288367 0.270858696153965 0.450567563886886 0.652301248686322 0.939577115195416 Possible toxin VapC30 Contains PIN domain V - Conserved hypotheticals Rv0625c - 25.5 7 4.4 22.8 18.5 16.5 17.1260623462436 0.504783827353281 0.564251164260418 0.894608393081328 0.370996463614678 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0626 vapB5 114.9 75.1 29.9 76 66.2 35.4 26.2774026940262 -0.432695799560359 0.458414749156201 -0.94389589418058 0.34522285036498 NA Possible antitoxin VapB5 V - Conserved hypotheticals Rv0627 vapC5 97 34.5 42.4 121.8 94.3 29.9 42.591684139742 0.371634264031794 0.409641153351294 0.907219064762991 0.364290963916656 0.882928450686174 Possible toxin VapC5 V - Conserved hypotheticals Rv0628c - 62.2 19.8 26.4 60.8 30.7 29.2 67.1630826727373 0.00654816578820034 0.35073474242617 0.0186698521592247 0.985104478553592 0.999019127881181 hypothetical protein V - Conserved hypotheticals Rv0629c recD 21.9 13.8 10.2 22.6 12.4 8 39.9787634132887 -0.207227725052941 0.390821200867716 -0.530236651934046 0.595947861907261 0.929194918847511 Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0630c recB 16 7.1 5.2 18.9 17.1 6.6 57.7555369791505 0.468672592446534 0.357729754261334 1.31013030608618 0.190151757647979 0.739746500217031 Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0631c recC 8.2 1.6 3.9 9.6 6.7 5.6 29.1292041869508 0.480896982202188 0.455833979951092 1.0549827422997 0.291433217646063 0.832752355381209 Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0632c echA3 451.9 334.9 250.5 351.7 439.4 353.6 408.795491094086 -0.0494017229066125 0.205336192216119 -0.240589456604983 0.809873322604791 0.965980858268586 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0633c - 97.9 50.4 54.3 58.9 78.3 35.5 83.1787104760537 -0.413851812851328 0.298544248367949 -1.38623274477311 0.165675845819499 0.725041090026968 Possible exported protein VI - Unknowns Rv0634c - 227.1 138.8 103.4 213.6 157.9 122.7 180.225654143077 -0.0761514029465353 0.227624427062895 -0.334548466213136 0.737965724769045 0.955176974595779 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) III.F - Detoxification Rv0634A - 421.8 259.6 176.9 567.9 472 331.9 145.343293709524 0.531688604642885 0.238042801733986 2.23358404778418 0.0255104545077921 0.335120884844735 hypothetical protein ? Rv0634B rpmG2 215.2 210.1 147.6 111.2 180.2 262.1 52.4031339716178 -0.319490674674537 0.404585849342235 -0.789673378824187 0.429718542171204 0.901158530199572 50S ribosomal protein L33 RpmG2 ? Rv0635 hadA 292.7 187.6 137.3 210.2 298.2 249.6 174.566758869361 0.129981000817859 0.246847332456833 0.52656433239192 0.5984961662963 0.930022694368295 (3R)-hydroxyacyl-ACP dehydratase subunit HadA V - Conserved hypotheticals Rv0636 hadB 318.8 148.4 176.8 427.6 345 257.4 187.205839729513 0.502057353859798 0.233975279999311 2.14577092871211 0.0318912591002735 0.380220787376537 (3R)-hydroxyacyl-ACP dehydratase subunit HadB VI - Unknowns Rv0637 hadC 366.1 210.7 173.7 319.9 331.7 453.9 248.237120844583 0.40822292775633 0.250287881447615 1.63101355685002 0.102887458974007 0.633823410962368 (3R)-hydroxyacyl-ACP dehydratase subunit HadC V - Conserved hypotheticals Rv0638 secE1 1000.2 429.6 464.9 603.1 587.9 461.6 455.100903775833 -0.344823609069793 0.19983973657522 -1.7255007186221 0.0844372743965051 0.562779520435502 Probable preprotein translocase SecE1 III.D - Protein and peptide secretion Rv0639 nusG 1027.1 591.2 597.7 642.8 651.4 730.4 826.376319281165 -0.301524521801159 0.204791298832553 -1.4723502586294 0.140926317943039 0.68386350075517 Probable transcription antitermination protein NusG II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0640 rplK 1165.4 823.3 764.7 600.5 851.4 1049.3 624.037996223977 -0.318753357525497 0.260981538391192 -1.22136362399592 0.221948373608921 0.774556499980442 50S ribosomal protein L11 RplK II.A.1 - Ribosomal protein synthesis and modification Rv0641 rplA 1348.3 745.5 612.4 1376.3 1035.1 844 1105.74271386053 0.107374727169385 0.174483932349618 0.61538461291803 0.53830075064728 0.924361123608528 50S ribosomal protein L1 RplA II.A.1 - Ribosomal protein synthesis and modification Rv0642c mmaA4 255.3 206.3 107.3 209.1 307 205.3 309.330185905373 0.180620624906277 0.238898359637894 0.756056362965613 0.449615403449509 0.901158530199572 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0643c mmaA3 111.1 52 49.9 98 110.3 128.5 127.629828909717 0.495438016272788 0.271827757643866 1.82261745660973 0.0683613498371671 0.520912460856883 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0644c mmaA2 47.6 42.1 19.9 51 61.9 58.7 63.8690578335668 0.481474870189879 0.327833512758336 1.46865665483321 0.141925939734537 0.685612916314031 Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0645c mmaA1 53.3 37.5 20.6 35.7 55.3 50.4 57.3928461869041 0.168629740951014 0.34826155351115 0.484204297749494 0.62824088710825 0.93413540068838 Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0646c lipG 87.3 60 34.9 88.2 101.3 49.4 98.5963384375137 0.240554340082427 0.278619500699458 0.863379409835025 0.387928896390135 0.893826103932853 Probable lipase/esterase LipG II.B.5 - Esterases and lipases Rv0647c - 101.4 59.4 34.9 116.8 87.7 97.9 189.716505270515 0.505927213167452 0.237226603492049 2.13267485905901 0.032951407679448 0.383117660251623 hypothetical protein V - Conserved hypotheticals Rv0648 - 5.6 3.1 2.2 4.1 2.3 5.7 21.7606441958985 -0.0169408393368083 0.502547097032809 -0.033709953627893 0.973108441637595 NA Alpha-mannosidase V - Conserved hypotheticals Rv0649 fabD2 2.9 2.6 0 3.3 0 4.2 1.66816789412258 0.279356781347106 1.65791599801463 0.168498754871561 0.866190923135506 NA Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) I.H.1 - Synthesis of fatty and mycolic acids Rv0650 - 0.7 0 0 1.2 2 0 0.602809523557377 1.31231592569993 2.5544450769777 0.513738164710358 0.607435065239128 NA Possible sugar kinase I.J.1 - Repressors/activators Rv0651 rplJ 119.8 80.7 57.2 131.3 132.8 124.8 91.1747515316159 0.431903291428361 0.269100988409807 1.60498589760148 0.108496908239627 0.643080319504058 50S ribosomal protein L10 RplJ II.A.1 - Ribosomal protein synthesis and modification Rv0652 rplL 99.4 37.6 60 156.6 99.5 92.8 55.4514959001057 0.643059126561205 0.3455641676621 1.86089643180251 0.0627588037769602 0.514454587842348 50S ribosomal protein L7/L12 RplL (SA1) II.A.1 - Ribosomal protein synthesis and modification Rv0653c - 7 6.8 1.6 6.3 0 7.3 5.02697106205239 -0.104768383409255 1.02340494009565 -0.102372364354097 0.918461118456215 NA Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv0654 - 24.1 15.4 10.5 19.9 26.3 18.3 44.8466701816064 0.193085391808499 0.351094252320151 0.549953155121523 0.582351504317024 0.928941202821899 Probable dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0655 mkl 1706.8 1245.8 956.3 1050.6 1243.1 1055.1 2131.71732272014 -0.406934388168749 0.181029015958787 -2.24789592990657 0.0245828267737615 0.327036611553196 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl II.C.5 - Other membrane proteins Rv0656c vapC6 58.5 23.6 19.2 41.9 56.4 38.6 22.6441097627138 0.248277893859132 0.476314918425988 0.521247360211983 0.60219446582464 NA Possible toxin VapC6 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0657c vapB6 213.7 102.8 79.3 133.8 101.3 154.8 31.9210426421797 -0.19919799139392 0.414309495109721 -0.480795139250108 0.630662105238473 0.93413540068838 Possible antitoxin VapB6 V - Conserved hypotheticals Rv0658c - 64.3 16.1 25.7 61.6 47.9 44 47.217507428898 0.374341276191803 0.373821166461518 1.00139133301415 0.316637652556559 0.847340730510678 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0659c mazF2 1190.1 507.5 408.5 947.2 975.4 647.1 370.806272672406 0.171953082005541 0.214603231759468 0.801260449787959 0.422980882117967 0.901158530199572 Toxin MazF2 V - Conserved hypotheticals Rv0660c mazE2 1025.8 469.9 481.6 1047.7 1173.7 638.4 308.333160438225 0.369022256047698 0.220445820956914 1.67398163614916 0.09413420849472 0.598404804898025 Possible antitoxin MazE2 V - Conserved hypotheticals Rv0661c vapC7 9.1 3.2 2.3 5.6 6 0.5 2.41359520714378 -0.306197590693297 1.33865461938255 -0.228735318475596 0.81907464224156 NA Possible toxin VapC7 V - Conserved hypotheticals Rv0662c vapB7 14.1 28.5 0 10.6 10.9 10.4 4.67673903304138 -0.752022689497747 1.09383176058346 -0.687512208547146 0.491760010054285 NA Possible antitoxin VapB7 VI - Unknowns Rv0663 atsD 79.2 49.4 40.6 61.5 67.2 50.3 219.205461571634 -0.0921932739603412 0.209818005546653 -0.439396388885425 0.660374342634489 0.939577115195416 Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) I.C.5 - Sulphur metabolism Rv0664 vapB8 36.6 24.1 14.7 23.5 12.7 35.6 10.270580560009 -0.336394790859692 0.679629354858391 -0.494968012277491 0.620622700320727 NA Possible antitoxin VapB8 VI - Unknowns Rv0665 vapC8 17.5 12.5 10.4 21.3 26.1 20.8 9.51418043979558 0.588566793727301 0.682508863559563 0.862357729184182 0.388490694078148 NA Possible toxin VapC8 V - Conserved hypotheticals Rv0666 - 21.4 8.6 6.9 15.2 16.8 24.5 3.45501414112209 0.427132647800171 1.1207816835037 0.381102452053734 0.703127227998594 NA Possible membrane protein VI - Unknowns Rv0667 rpoB 636.5 351.1 396.7 623.1 590 449.5 2866.69987844785 0.0615911389172281 0.179889403998301 0.342383361933924 0.732062407974904 0.951379060695889 DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0668 rpoC 469.7 312.7 249.6 536.3 471.2 391.2 2546.21926863917 0.253597324440052 0.15634135005465 1.62207454618632 0.104787387503932 0.637015195243683 DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0669c - 18 9.8 4 20.6 12.7 12.9 37.1028343631336 0.437004040875222 0.412585905299052 1.05918315498071 0.289516375087967 0.830707773333317 Possible hydrolase V - Conserved hypotheticals Rv0670 end 348.7 180.8 135.7 284.2 280.1 238.3 290.675740786357 0.13325614734138 0.202741178414537 0.657272234399843 0.511005886326447 0.915911629458156 Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) II.B.2 - DNA Rv0671 lpqP 157.1 96.9 68.6 81.9 127.7 65 132.755608015575 -0.395650740670898 0.26710616705494 -1.48124899186442 0.138540235416961 0.682181933169668 Possible conserved lipoprotein LpqP II.C.1 - Lipoproteins(lppA-lpr0) Rv0672 fadE8 100.5 65.9 44.8 97.5 96.3 95.7 215.271193759022 0.297324627186008 0.217252555806542 1.3685667636093 0.171134739217974 0.729366238331149 Probable acyl-CoA dehydrogenase FadE8 I.A.3 - Fatty acids Rv0673 echA4 60.1 32.2 27.1 84.7 70 22.8 70.5308967436921 0.420513247523958 0.343936138736632 1.22264920769482 0.221462218865306 0.774556499980442 Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0674 - 41.4 42 26.1 57.4 40 30.6 45.9415628930226 0.0868913895057923 0.366110714128233 0.237336374360674 0.812395845435124 0.966073477417693 hypothetical protein VI - Unknowns Rv0675 echA5 21.9 17 12 33.6 25 27.5 27.9629375159255 0.580682226583003 0.423332566141124 1.37169278488588 0.17015909545514 0.726605873444774 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0676c mmpL5 123.4 80.4 80.4 67.7 79.1 66.2 394.937324333875 -0.629362302998368 0.210388237929822 -2.99143292985941 0.00277671526505627 0.0925348725680197 Probable conserved transmembrane transport protein MmpL5 II.C.4 - Conserved membrane proteins Rv0677c mmpS5 302.4 167.9 163.7 165 212.7 221.3 142.508350237207 -0.280867966507394 0.26388924989889 -1.06434031175961 0.287174562557899 0.829758572569927 Possible conserved membrane protein MmpS5 II.C.4 - Conserved membrane proteins Rv0678 - 170.6 129.5 97.9 126.9 119.3 117.5 102.438082416714 -0.324733321268486 0.264719706240887 -1.22670626180352 0.219933013342476 0.773070552038584 hypothetical protein VI - Unknowns Rv0679c - 105.1 67.4 46.8 36.3 99.1 93.2 59.7829067353087 -0.135571876126992 0.40219940610659 -0.337076271293805 0.736059404531195 0.953602020109268 Conserved threonine rich protein II.C.5 - Other membrane proteins Rv0680c - 78.9 24.4 54.9 53.1 35.4 23.1 26.9893347767459 -0.655401534675051 0.479902875950514 -1.36569620129268 0.172034337148168 0.729574936755292 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0681 - 56.5 24.3 17 51 19.4 44.8 31.7477941929331 0.126563898143868 0.450114388700457 0.281181631427681 0.778571092552634 0.963013023606306 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0682 rpsL 689.8 378.7 469 620.8 556.9 579.1 334.350473050814 -0.0160340828150632 0.223695196476387 -0.071678261615044 0.942857956373036 0.998153412295216 30S ribosomal protein S12 RpsL II.A.1 - Ribosomal protein synthesis and modification Rv0683 rpsG 579.9 372.3 390.2 504.7 506.4 500.7 364.935322590602 -0.0364952700754271 0.213616207426184 -0.170845042682626 0.864345610760175 0.97763538285617 30S ribosomal protein S7 RpsG II.A.1 - Ribosomal protein synthesis and modification Rv0684 fusA1 562.1 356.9 344.5 610.9 570 487.6 1652.17997487372 0.202300228043212 0.170832006642498 1.18420565337366 0.236331664794414 0.78958848015113 Probable elongation factor G FusA1 (EF-G) II.A.6 - Protein translation and modification Rv0685 tuf 912.9 653.5 498.2 832.8 932.7 826.9 1488.27762770333 0.150233728517058 0.179044002814469 0.83908830318508 0.401419759355062 0.893826103932853 Probable iron-regulated elongation factor TU Tuf (EF-TU) II.A.6 - Protein translation and modification Rv0686 - 181.4 90 96.5 130 140.6 93.2 154.429566364345 -0.198386292398036 0.237485856624855 -0.835360451428557 0.403514790199953 0.894328453279704 Probable membrane protein II.C.5 - Other membrane proteins Rv0687 - 33.4 18 12.9 33.9 26.8 42.9 35.9612515785893 0.512683202057063 0.397168803498938 1.29084459187247 0.196757571731845 0.751109817915875 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0688 - 37.2 26.3 7.5 43.5 40.4 33.6 58.7321208580226 0.626439624927738 0.35616475028819 1.75884790513619 0.0786033455315001 0.55131591065269 Putative ferredoxin reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0689c - 3.5 0 2.1 6 0 1.1 0.454333306324318 0.642977020788941 3.06635436825204 0.20968777367877 0.833911368591974 NA Hypothetical protein VI - Unknowns Rv0690c - 232.9 155.3 111.8 182.1 238.2 146.2 296.448561599865 0.00740361221445336 0.212433459233426 0.0348514412050229 0.972198201371811 0.998153412295216 hypothetical protein VI - Unknowns Rv0691c - 371 238.3 98.4 293.6 279.9 270.7 240.3173250884 0.157185231186498 0.255053661415831 0.616282982623912 0.537707768272744 0.924361123608528 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0691A - 278.5 230.7 218.8 432.2 402.5 364.8 97.7872591376202 0.50164536340588 0.28323499238039 1.77112778046916 0.0765394552971194 0.545639518948021 Mycofactocin precursor protein ? Rv0692 - 1135.8 1120.5 757.3 1185.7 1179.3 1142.2 587.436045691293 0.000495499576200629 0.217633360328925 0.00227676297168662 0.998183407545714 0.999833281786427 hypothetical protein VI - Unknowns Rv0693 pqqE 1171.5 888.4 635.2 1020.3 1106 948.5 1824.75732523343 0.00668583620292882 0.175848370972651 0.0380204614120005 0.969671367974142 0.998153412295216 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0694 lldD1 532.9 332.7 231.1 572.6 520.3 431.7 818.558458726699 0.324646927032071 0.169016367582516 1.92080170503945 0.0547567114493233 0.485439307271885 Possible L-lactate dehydrogenase (cytochrome) LldD1 I.B.6.a - aerobic Rv0695 - 189.1 159.6 80.8 254.8 185.1 153.9 202.836969790926 0.311800858015781 0.24077266672012 1.29500105748393 0.195319864684768 0.750353813497318 hypothetical protein V - Conserved hypotheticals Rv0696 - 106.1 103.7 44.5 132.2 141.6 116.6 240.890110175221 0.46132913598088 0.248967367115212 1.85297029617298 0.0638866162628162 0.514454587842348 Probable membrane sugar transferase IV.H - Miscellaneous transferases Rv0697 - 48.5 58.1 27 71.8 64.9 48.6 122.440493150248 0.295816412352268 0.287673369138154 1.02830655906214 0.303805646683954 0.84454916455057 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0698 - 53.9 39.3 24.1 57 57.2 40.6 43.0661954890745 0.247638532804865 0.351635329256605 0.704248157681992 0.48127824524794 0.907292899730371 hypothetical protein V - Conserved hypotheticals Rv0699 - 17.7 8.2 3.5 27.4 0 17.7 3.70832204669455 0.681433351994031 1.17052475252486 0.582160565613123 0.560458532667322 NA Hypothetical protein VI - Unknowns Rv0700 rpsJ 1044.5 490.7 617.9 656.4 838.4 552.8 344.368313679149 -0.264817071079177 0.226071294535148 -1.17138742282031 0.241443085423513 0.78958848015113 30S ribosomal protein S10 RpsJ (transcription antitermination factor NusE) II.A.1 - Ribosomal protein synthesis and modification Rv0701 rplC 750.8 318.8 394.7 549.3 600.5 382.3 517.459892583348 -0.104881101831534 0.212182712002225 -0.494296169757852 0.621097029782701 0.931582271037618 50S ribosomal protein L3 RplC II.A.1 - Ribosomal protein synthesis and modification Rv0702 rplD 715.9 279.1 410.7 608.6 580.2 444.4 540.654101516431 0.0361021383588556 0.223500374719045 0.161530549576207 0.871675552194997 0.977891032682394 50S ribosomal protein L4 RplD II.A.1 - Ribosomal protein synthesis and modification Rv0703 rplW 814.2 337.9 589.5 752.9 846.3 636 323.378602362102 0.144186041069293 0.256617144982967 0.561872204910016 0.574203092443126 0.925885039001838 50S ribosomal protein L23 RplW II.A.1 - Ribosomal protein synthesis and modification Rv0704 rplB 741.4 364.7 455.5 589.2 758.1 660.5 807.941104773021 0.183908245912688 0.219464527821604 0.837986200950801 0.40203845349305 0.893826103932853 50S ribosomal protein L2 RplB II.A.1 - Ribosomal protein synthesis and modification Rv0705 rpsS 965.7 588.5 615.1 713.4 1083.1 1120.7 389.750379923875 0.247545429528264 0.256461911233264 0.965232725350431 0.334428259161581 0.853347384539607 30S ribosomal protein S19 RpsS II.A.1 - Ribosomal protein synthesis and modification Rv0706 rplV 491.6 241 312.9 434.1 488.2 410.5 378.329241438275 0.153688907646677 0.221285021428893 0.694529194313604 0.487350398871737 0.909299509995111 50S ribosomal protein L22 RplV II.A.1 - Ribosomal protein synthesis and modification Rv0707 rpsC 584.4 331.6 327.7 608.5 563.2 562 654.427451278978 0.303133065134288 0.18652353923714 1.62517324287362 0.1041256500347 0.635787081668831 30S ribosomal protein S3 RpsC II.A.1 - Ribosomal protein synthesis and modification Rv0708 rplP 681.8 465.2 378.9 497.2 668.8 625.3 373.111036008092 0.0521931412849289 0.223979466465844 0.233026455989385 0.81574086228777 0.966726317518412 50S ribosomal protein L16 RplP II.A.1 - Ribosomal protein synthesis and modification Rv0709 rpmC 1579.8 1240 1018.5 1176.3 2241.2 1899.7 582.858326363096 0.279497912017618 0.262322509303849 1.0654743764054 0.286661314989451 0.829758572569927 50S ribosomal protein L29 RpmC II.A.1 - Ribosomal protein synthesis and modification Rv0710 rpsQ 1012.4 723 574 1202.3 1210.3 1169.4 646.184122387479 0.449635269724983 0.187757598705531 2.39476470100242 0.0166310341945019 0.276757764055105 30S ribosomal protein S17 RpsQ II.A.1 - Ribosomal protein synthesis and modification Rv0711 atsA 142.2 102 79.7 112.5 141.9 127.6 449.438603714248 0.0561587300455972 0.210126576025878 0.267261434073341 0.789267878191222 0.963989543249515 Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) I.C.5 - Sulphur metabolism Rv0712 - 60 34.7 34 60.6 31.5 35.6 60.8611192264383 -0.182456977406863 0.331417645307309 -0.550534891519364 0.581952552035172 0.928941202821899 hypothetical protein V - Conserved hypotheticals Rv0713 - 39.3 34.2 15.2 50.6 70.9 51.7 64.2253138786058 0.808191468061515 0.330551502527986 2.44497895753201 0.0144860593496911 0.263608158955562 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0714 rplN 487.6 203.1 188.7 316.4 443.7 398.3 196.388080649135 0.267072758813742 0.257907840904165 1.0355356311675 0.300418835233317 0.841903240380299 50S ribosomal protein L14 RplN II.A.1 - Ribosomal protein synthesis and modification Rv0715 rplX 551.5 358.9 245.3 539.4 553 476.4 228.376077349135 0.281653893737505 0.20946603620293 1.34462798286133 0.178745402025208 0.734764437650925 50S ribosomal protein L24 RplX II.A.1 - Ribosomal protein synthesis and modification Rv0716 rplE 372.7 181.9 168.3 349 290.5 214 231.935223212089 0.0877542391923275 0.214193484173753 0.409696119052537 0.682028877346657 0.942913432418385 50S ribosomal protein L5 RplE II.A.1 - Ribosomal protein synthesis and modification Rv0717 rpsN1 352.3 237.7 299.2 322.5 393.8 486.2 107.166890277899 0.199533483088353 0.317252028658455 0.628943127431238 0.529386290095705 0.922751607774049 30S ribosomal protein S14 RpsN1 II.A.1 - Ribosomal protein synthesis and modification Rv0718 rpsH 468.4 218.4 254.4 517.6 631.7 492.5 270.799397170585 0.625888711326809 0.222987959288918 2.80682738800199 0.00500320431971402 0.13838863148329 30S ribosomal protein S8 RpsH II.A.1 - Ribosomal protein synthesis and modification Rv0719 rplF 504.2 307.1 290.8 451.1 470.8 452.9 358.609203003659 0.130680028095243 0.20290519188363 0.644044772251025 0.519546401525613 0.915911629458156 50S ribosomal protein L6 RplF II.A.1 - Ribosomal protein synthesis and modification Rv0720 rplR 397.6 235.4 290.5 515.7 471.8 441 232.472353388192 0.413963550846391 0.233367415210686 1.77387040291234 0.0760845894011843 0.545639518948021 50S ribosomal protein L18 RplR II.A.1 - Ribosomal protein synthesis and modification Rv0721 rpsE 530.4 356.5 276.5 762.8 560.2 510.6 523.060233925092 0.478328326923663 0.186681590295123 2.56226833169505 0.0103990939578654 0.213002423814401 30S ribosomal protein S5 RpsE II.A.1 - Ribosomal protein synthesis and modification Rv0722 rpmD 362.6 247.7 212.6 324.7 478.1 379.3 106.096304227882 0.322514404888397 0.280489788040305 1.14982583552045 0.250215612024269 0.796128980119145 50S ribosomal protein L30 RpmD II.A.1 - Ribosomal protein synthesis and modification Rv0723 rplO 1082.9 880 501.6 1145.5 1268.2 981.3 684.962246055277 0.290918867285677 0.196634156801482 1.47949304443267 0.139008588968225 0.682181933169668 50S ribosomal protein L15 RplO II.A.1 - Ribosomal protein synthesis and modification Rv0724 sppA 562 362.9 292.9 483.8 423.5 332.1 1226.54363053365 -0.157483417241417 0.162723961302776 -0.967794883928565 0.3331468193996 0.853347384539607 Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) II.B.3 - Proteins, peptides and glycopeptides Rv0724A - 36 19.6 10.8 40.9 42.6 28.9 14.4583052214427 0.588125038421156 0.567883036751956 1.03564466687537 0.300367945530911 NA hypothetical protein ? Rv0725c - 32.1 15.1 11.1 29.6 35.9 15.1 31.6968563135997 0.332380821072602 0.414759425601271 0.801382200273699 0.422910416530771 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0726c - 45.3 19.7 21.2 32.6 29.1 26.7 50.5908661434654 -0.14180181933519 0.33411509893044 -0.424410090382393 0.671266763146137 0.940710721884994 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0727c fucA 2.8 0 2.4 2.7 5.5 0 2.0549729266157 0.417584039252247 1.47080522471101 0.283915254199819 0.77647532616949 NA Possible L-fuculose phosphate aldolase FucA (L-fuculose-1-phosphate aldolase) I.A.1 - Carbon compounds Rv0728c serA2 3.4 0 0 2.6 0.1 0 1.14788946066808 -0.20842465808582 2.16105307544105 -0.0964458765286378 0.923166457717667 NA Possible D-3-phosphoglycerate dehydrogenase SerA2 (phosphoglycerate dehydrogenase) (PGDH) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0729 xylB 8.5 7.1 3.3 12.6 6.5 12.6 17.5477019569637 0.635492601232759 0.545685311662094 1.16457706969814 0.244190230063844 NA Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase) I.A.1 - Carbon compounds Rv0730 - 188.3 138.1 75.2 174.2 206.7 130.5 174.35093894379 0.195409136886065 0.239057354730746 0.817415289758215 0.413691140907349 0.901158530199572 GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv0731c - 8.9 5.6 1.2 7 1.1 4.6 6.07129000768291 -0.454144988042459 0.975961212390793 -0.465330980654394 0.64169445209981 NA Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0732 secY 110.4 113.8 41.9 130.4 151.7 127.1 236.822501337477 0.469914146343698 0.269269328688186 1.74514545950333 0.0809595521952573 0.558439205416663 Probable preprotein translocase SecY III.D - Protein and peptide secretion Rv0733 adk 180.4 104.2 91.8 302.5 180.2 149.7 142.543392914365 0.586536806356723 0.259614578976569 2.2592598946828 0.0238672230657004 0.323611465684937 Adenylate kinase Adk (ATP-AMP transphosphorylase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv0734 mapA 132.5 52.4 62.1 169.9 108.1 100.9 129.288829144378 0.463667031649894 0.269326311536701 1.72158089198319 0.085145467047224 0.565416432304519 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) II.B.3 - Proteins, peptides and glycopeptides Rv0735 sigL 24.8 15.7 14.9 25.6 21.1 32.2 19.1727370881335 0.303655893413647 0.506038938622351 0.600064284065421 0.54846339426204 NA Probable alternative RNA polymerase sigma factor SigL II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0736 rslA 11.2 4.3 8.4 8.4 2.5 0 6.66913434006714 -1.16410586390418 0.923130463056259 -1.26104154341317 0.207293879951527 NA Anti-sigma factor RslA VI - Unknowns Rv0737 - 8.9 8.6 2.2 7.4 0 5.7 3.77676713533095 -0.708107171488146 1.15684457104509 -0.612102255749398 0.540470105193592 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0738 - 35.3 20.4 13.9 25.8 18.3 8.8 16.5287889869391 -0.485795573917095 0.55192136943434 -0.880189825617702 0.378756484301063 NA hypothetical protein II.C.5 - Other membrane proteins Rv0739 - 12.1 19.8 8.4 7.9 14.2 16.7 17.1709050267278 -0.356392558250641 0.59267129664396 -0.601332577212255 0.547618495680031 NA hypothetical protein V - Conserved hypotheticals Rv0740 - 71.7 39.1 45.3 49.1 25.7 53 40.5193564899657 -0.496909575224035 0.393808339909791 -1.26180561675728 0.207018740594471 0.770341510876847 hypothetical protein V - Conserved hypotheticals Rv0741 - 66.3 54.5 36.2 111.5 75.8 79 34.3873436586 0.621832517513343 0.39169710024988 1.58753413573052 0.112391722072764 0.648445531184945 Probable transposase (fragment) IV.B.1.c - Others Rv0742 PE_PGRS8 16.5 8.7 4.7 21.6 17.7 11.9 9.9911711106643 0.676123469639502 0.679013919355985 0.995743165737715 0.319374951054757 NA PE-PGRS family protein PE_PGRS8 IV.C.1.b - PE_PGRS subfamily Rv0743c - 32.9 17 9.6 28.5 20.6 19.8 17.8951742135474 0.0561910900835229 0.518805424348941 0.108308601734529 0.913750899560099 NA Hypothetical protein VI - Unknowns Rv0744c - 51.3 35.2 33.9 53.2 47.9 23 32.2231114402234 -0.147638997061247 0.411301646026973 -0.358955522029603 0.719628363069063 0.949890877982223 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0745 - 0.3 0 0.1 0.7 0 0.1 0.0967830325524829 0.745394649664457 4.00663173781962 0.186040219925501 0.852413220923028 NA hypothetical protein V - Conserved hypotheticals Rv0746 PE_PGRS9 7.6 4.4 3.1 10.4 3.9 2.3 18.8784876758873 0.0639768570986351 0.554046221651638 0.115472057381633 0.908070967281432 NA PE-PGRS family protein PE_PGRS9 IV.C.1.b - PE_PGRS subfamily Rv0747 PE_PGRS10 19.5 6.8 10.4 19.9 9.2 3.8 42.6722644235142 -0.271378097432365 0.444165828650871 -0.610983736089426 0.541210347485908 0.92521033104044 PE-PGRS family protein PE_PGRS10 IV.C.1.b - PE_PGRS subfamily Rv0748 vapB31 88.8 51.2 53.4 81.2 83 107.4 31.8233588769913 0.282591279552699 0.412818158681084 0.684541785796323 0.493633112682289 0.913326614478915 Possible antitoxin VapB31 V - Conserved hypotheticals Rv0749 vapC31 25.1 8.1 12.2 14.5 4.1 6.6 7.31024120814216 -1.10937241307292 0.844282349583035 -1.31398271398283 0.188852021434394 NA Possible toxin VapC31 Contains PIN domain V - Conserved hypotheticals Rv0749A - 174.4 79.8 64.3 111.4 151.4 117.7 24.2167766963264 0.0606357086590362 0.457759432244736 0.132461953567388 0.894618914453471 NA hypothetical protein ? Rv0750 - 198.3 74.3 76.2 92.1 159.8 117.8 45.8086658300712 -0.0959057330152091 0.383269552924963 -0.250230503005767 0.802409097445395 0.965592404376002 hypothetical protein V - Conserved hypotheticals Rv0751c mmsB 72.4 43.5 32.9 49.6 48.9 34.7 66.0012972301918 -0.314358713672841 0.297612821312902 -1.05626737546476 0.290846076640633 0.832752355381209 Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh) I.A.2 - Amino acids and amines Rv0752c fadE9 47.4 24.1 26.6 30.4 46.6 26.4 62.614142329549 -0.130553069317163 0.325774929173186 -0.400746213493178 0.688606982552748 0.942913432418385 Probable acyl-CoA dehydrogenase FadE9 I.A.3 - Fatty acids Rv0753c mmsA 52.9 43.8 32.5 35.6 48.6 27.7 100.150857183882 -0.405560567484672 0.282161083785328 -1.43733700637905 0.150622258556254 0.697857901451589 Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) I.A.2 - Amino acids and amines Rv0754 PE_PGRS11 6 1 5.5 6.9 8.9 0 12.450314248876 0.180248780091399 0.743655863897868 0.242381979141032 0.808484196689892 NA PE-PGRS family protein PE_PGRS11 IV.C.1.b - PE_PGRS subfamily Rv0755c PPE12 69.7 61.6 64.8 49.1 100.8 85.4 233.226045595116 0.00856912911870138 0.313315915864666 0.027349804733197 0.978180733274546 0.998567088804884 PPE family protein PPE12 IV.C.2 - PPE family Rv0755A - 256.5 157.2 105.3 260.7 211.7 232 59.4037091587897 0.282490390045741 0.313548284417731 0.900947012261078 0.367616493489948 0.883373818299354 Putative transposase (fragment) ? Rv0756c - 139.6 66.8 51.5 98.4 49.4 78.7 91.5775504413829 -0.310817614527501 0.304679541182489 -1.02014599772991 0.307659224447731 0.844880251285152 hypothetical protein VI - Unknowns Rv0757 phoP 200.1 148.2 120.7 153.8 124.6 112.6 173.428640883434 -0.45388769380093 0.229928605929778 -1.97403751466901 0.0483774774181699 0.443086432247212 Possible two component system response transcriptional positive regulator PhoP I.J.2 - Two component systems Rv0758 phoR 62.2 29 26.2 53.9 38 35.6 92.6288239384648 -0.0197536718024352 0.276696486044794 -0.0713911191457537 0.943086477471165 0.998153412295216 Possible two component system response sensor kinase membrane associated PhoR I.J.2 - Two component systems Rv0759c - 136.7 45.9 79.5 115.6 119.6 97.1 51.8658648961174 0.140737810653094 0.352142778423761 0.399661214928377 0.689406062534391 0.942913432418385 hypothetical protein V - Conserved hypotheticals Rv0760c - 100.6 58.9 48.6 89.2 69.2 129.6 55.5170765833398 0.303707968489908 0.356956067604282 0.850827303562175 0.394865292209166 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv0761c adhB 112.6 79.9 67.1 137.1 114.5 126 192.100654506455 0.350088185833993 0.227647009180317 1.53785541525253 0.124083970625517 0.666956030977941 Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0762c - 25.3 24.4 9.2 22.9 24.6 23.5 18.0411732291692 0.1484415773745 0.522148297210451 0.284290072700689 0.776188093267629 NA hypothetical protein VI - Unknowns Rv0763c - 17 17.5 13 8.2 9.8 0 3.36037420031949 -1.6757435239392 1.21573803202425 -1.37837550508232 0.168087382096213 NA Possible ferredoxin IV.F - Cytochrome P450 enzymes Rv0764c cyp51 28.8 24.1 10.2 20.1 28.1 23 47.8120065258186 0.0147726204049495 0.365952493238856 0.0403675905421622 0.967800068179188 0.998153412295216 Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) IV.F - Cytochrome P450 enzymes Rv0765c - 15 11.4 7 9.6 13.5 21.6 17.3040645137965 0.157943572132021 0.55774598993806 0.283181905350071 0.777037398327903 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0766c cyp123 9.7 15 1.5 12.9 10.4 11.1 18.4856808589864 0.308881333318608 0.600750074020864 0.514159459442498 0.607140509098193 NA Probable cytochrome P450 123 Cyp123 IV.F - Cytochrome P450 enzymes Rv0767c - 5.7 4 1.7 4.2 0 2 2.22060423551457 -0.984710940905434 1.49324223864961 -0.659444874661423 0.509610133847707 NA hypothetical protein VI - Unknowns Rv0768 aldA 8.8 5 4.6 6.1 8.6 7.5 15.4737434500185 0.0171176147189115 0.549673861174486 0.0311414020712871 0.975156771590124 NA Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0769 - 15.3 9 4 12.5 11.9 3.8 10.0017785571708 -0.0735146605983379 0.696096750602224 -0.105609831585533 0.915891923902548 NA Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0770 - 9.1 5.8 7 14 8.3 8.2 11.9730867526462 0.290662738489653 0.621426424552946 0.467734758300238 0.639974281419165 NA Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0771 - 7.9 0.1 4.1 3.2 0 6.5 1.99713538793424 -0.834527652647525 1.55596254695908 -0.536341735396202 0.591722391335379 NA Possible 4-carboxymuconolactone decarboxylase (CMD) II.B.6 - Aromatic hydrocarbons Rv0772 purD 18.7 8.2 2.7 16.5 7.8 11.8 20.4125269899214 0.201995038489002 0.541684338279111 0.372901751471575 0.709221568406885 NA Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv0773c ggtA 35.5 26.8 10 40.9 43.1 19.4 68.4442610627131 0.39540984347524 0.336704663687176 1.17435214334484 0.240254005552112 0.78958848015113 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv0774c - 56.4 30.8 21.2 51.5 36.9 19.5 50.4863853631499 -0.126530003309224 0.354703401798398 -0.3567205802586 0.721300997028167 0.949890877982223 Probable conserved exported protein V - Conserved hypotheticals Rv0775 - 100.7 70.5 42.8 80.9 45.4 66.6 67.1632071613138 -0.294795730839869 0.319021524299122 -0.924062197644889 0.355453933593132 0.873942738060982 hypothetical protein V - Conserved hypotheticals Rv0776c - 8.5 8.8 1.4 9.5 16.6 3.6 8.63513338501 0.597717969114377 0.786559073263145 0.759914912219706 0.44730544729887 NA hypothetical protein V - Conserved hypotheticals Rv0777 purB 117.5 65.6 67.6 103.6 88.4 72.5 195.150300093446 -0.110036339027718 0.220361716838222 -0.499344171966588 0.617536941762388 0.931582271037618 Probable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE) I.F.1 - Purine ribonucleotide biosynthesis Rv0778 cyp126 96.2 66 27.6 101.3 70.4 56.1 133.840160376756 0.159012163367892 0.280488486225277 0.566911553154376 0.570774274472351 0.925417141377798 Possible cytochrome P450 126 Cyp126 IV.F - Cytochrome P450 enzymes Rv0779c - 7.8 2.8 3.5 4.9 8.9 4.6 4.5721356146815 0.177459889822627 0.979647791586621 0.181146623660751 0.856252489510999 NA Possible conserved transmembrane protein V - Conserved hypotheticals Rv0780 purC 34.8 18.2 13.3 25.9 19.9 29.8 32.7965142364917 0.0143516605699555 0.405442878562634 0.0353974908150678 0.971762785499191 0.998153412295216 Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC (SAICAR synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv0781 ptrBa 86.9 61.1 40.2 49.9 106.3 87.6 81.9029010219138 0.183467561113849 0.341616980247874 0.53705632834974 0.591228705777685 0.928941202821899 Probable protease II PtrBa [first part] (oligopeptidase B) II.B.3 - Proteins, peptides and glycopeptides Rv0782 ptrBb 23.7 19.2 12.4 20.9 30.1 20.7 55.7225443210074 0.205785467185595 0.334737969265877 0.614765835010914 0.538709375002512 0.924361123608528 Probable protease II PtrBb [second part] (oligopeptidase B) II.B.3 - Proteins, peptides and glycopeptides Rv0783c emrB 48.6 27.6 18.8 48 37.6 30.6 88.8581909428963 0.158560130834242 0.27441678881716 0.577807689965675 0.563393962884699 0.92521033104044 Possible multidrug resistance integral membrane efflux protein EmrB III.A.6 - Efflux proteins Rv0784 - 24 10 10.1 27.8 19 24.7 20.0657617340553 0.553299035005974 0.497445895470155 1.11227982790577 0.266017854281743 NA hypothetical protein V - Conserved hypotheticals Rv0785 - 18.3 10.1 6.1 22.9 16.6 10 36.0596973853986 0.419084995585896 0.394291407569058 1.06288138047364 0.287835747831692 0.829758572569927 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0786c - 116.9 65 63.6 83 84.4 65.6 49.4143197995976 -0.261972164170658 0.332966590581797 -0.786782132444313 0.431409414726396 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0787 - 8.7 3.7 6.1 8.8 9.6 12.1 12.0021585165015 0.416026008787416 0.626527597425563 0.664018648973948 0.506678375246702 NA hypothetical protein VI - Unknowns Rv0787A - 193.7 94.1 120.9 137.9 122.8 115.9 50.265648128246 -0.329960092983098 0.342360250889406 -0.96378038082957 0.335156044861276 0.853852514149632 hypothetical protein ? Rv0788 purQ 121.1 51.8 63 138.8 100.8 92.9 99.7403946313368 0.322155135861877 0.275887631533099 1.16770416300169 0.242926116999317 0.78958848015113 Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I) I.F.1 - Purine ribonucleotide biosynthesis Rv0789c - 15.2 14.8 5 11.3 22.2 2.2 10.1937233160543 -0.0982909519437774 0.738434657452034 -0.133107176040369 0.894108619990913 NA Hypothetical protein VI - Unknowns Rv0790c - 15.3 11.8 5.4 12.6 23 29.7 18.5132847730162 0.790976649692153 0.558429302966732 1.4164311319087 0.156649314364097 NA Hypothetical protein VI - Unknowns Rv0791c - 17 15.2 7.2 19.4 18 10.7 23.2014795541149 0.15219811085349 0.465024322779752 0.327290645667098 0.743448066868805 NA hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0792c - 27.9 19.8 8.7 24 16.4 13.7 22.6100726599353 -0.143726518161509 0.476517611129939 -0.301618481257594 0.762942917761484 NA Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0793 - 1.9 0 0 1.5 0 0 0.186384600704998 -0.0729724104909624 3.99857105658927 -0.0182496220420319 0.985439716550585 NA Possible monooxygenase V - Conserved hypotheticals Rv0794c - 21.4 10.9 12.4 23.1 18.4 7.6 36.0655527401337 -0.00282066274814693 0.405491949248847 -0.00695614981597555 0.994449840219445 0.999833281786427 Probable oxidoreductase I.B.3 - TCA cycle Rv0795 - 11.9 12.4 4.6 7.3 16.6 4.3 3.85764505697074 -0.368316261027143 1.07861748203297 -0.341470694812904 0.732749262685049 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv0796 - 6.4 6.5 4.2 2.4 6 3 7.17282145718354 -1.00832233274206 0.827001004184456 -1.21925164254959 0.222748696482532 NA Putative transposase for insertion sequence element IS6110 IV.B.1.a - IS6110 Rv0797 - 5.2 1.3 3.9 6.5 4.7 1.5 6.1587825842794 0.143958486377667 0.866113317106241 0.166212068945719 0.86799006191407 NA Putative transposase for insertion sequence element IS1547 IV.B.1.c - Others Rv0798c cfp29 75.7 32.6 42.2 63.8 84.9 88.5 82.1752573170585 0.452407154511149 0.314121506637428 1.44022979946208 0.149802394977283 0.695223866622759 29 KDa antigen CFP29 IV.E - Bacteriocin-like proteins Rv0799c - 70.7 79.2 44.2 64.7 108 90 125.338046862344 0.227371828101223 0.310958374580498 0.731196991905948 0.464658837278069 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0800 pepC 21.2 15.5 13.2 18.8 19.2 8.8 32.8796091417023 -0.272837743273066 0.404611556570043 -0.674320193881645 0.500107768210725 0.915911629458156 Probable aminopeptidase PepC II.B.3 - Proteins, peptides and glycopeptides Rv0801 - 42.9 17.1 6.8 61.8 26.7 37.5 15.8134928908906 0.851453300564903 0.606704096141894 1.40340786551368 0.16049524884947 NA hypothetical protein VI - Unknowns Rv0802c - 13 10 4.4 9.3 10.7 12.9 10.1862972225071 0.106256070468388 0.67602946805621 0.157176684581379 0.875105602904251 NA Possible succinyltransferase in the GCN5-related N-acetyltransferase family IV.D - Antibiotic production and resistance Rv0803 purL 46.6 21.5 22.9 63.2 44 30.6 133.589870536229 0.437383790220799 0.262771677561402 1.66450126695483 0.096012298085985 0.606108312609709 Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) I.F.1 - Purine ribonucleotide biosynthesis Rv0804 - 36.1 17.1 14.9 67.1 52.2 30.3 34.2122966661517 0.999321306499366 0.401977337086824 2.48601404681558 0.0129182866450754 0.248138755974156 hypothetical protein V - Conserved hypotheticals Rv0805 - 325.5 136.5 142.3 216.8 193.3 173.6 298.099379189428 -0.194033407027617 0.212401358433689 -0.913522439114689 0.360967837564119 0.882466185309938 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) V - Conserved hypotheticals Rv0806c cpsY 17.4 16.5 4.5 9.8 15.1 22.4 36.4099018531208 0.151441411155535 0.468724813323252 0.323092370727758 0.746625287960816 0.956095160416489 Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0807 - 41.9 14.5 5.2 62.5 29 7.3 14.251549411004 0.636548170809844 0.695667798574636 0.915017443834654 0.36018247261576 NA hypothetical protein V - Conserved hypotheticals Rv0808 purF 411.6 282.4 222 271.1 237.5 230.2 709.726752555754 -0.491898380392452 0.177330561361459 -2.77390640742291 0.00553876103139793 0.143179560867726 Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) I.F.1 - Purine ribonucleotide biosynthesis Rv0809 purM 226.9 136.5 100.2 202.8 164.7 125.2 274.644678859076 -0.0668307522600044 0.203128035842657 -0.329008016952281 0.742149628425415 0.955781054558401 Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) I.F.1 - Purine ribonucleotide biosynthesis Rv0810c - 725.8 418.6 266 584.2 517 443.4 140.783766550333 -0.00794640288576104 0.240401445339725 -0.0330547217573152 0.973630949803961 0.998153412295216 hypothetical protein VI - Unknowns Rv0811c - 135.1 98.5 56.2 135.8 127.3 75.8 181.896626136149 0.0774609453239571 0.236798757695836 0.327117194691766 0.743579247133029 0.956095160416489 hypothetical protein V - Conserved hypotheticals Rv0812 - 44.1 35.8 13.3 28.7 17 18.5 35.8427473341607 -0.655493873071513 0.414479580635303 -1.58148652839976 0.113766836798518 0.650163368976656 Probable amino acid aminotransferase I.G.2 - Folic acid Rv0813c - 133.5 44 63 110.1 119.8 96.6 100.198181266059 0.261216197636518 0.286931402754605 0.910378561317392 0.362622899987 0.882928450686174 hypothetical protein V - Conserved hypotheticals Rv0814c sseC2 277.9 125.7 126.9 295.3 102.1 128 82.2625212666872 -0.151912046740925 0.351064445268093 -0.432718404807175 0.665219357304321 0.940245605545295 Conserved protein SseC2 I.C.5 - Sulphur metabolism Rv0815c cysA2 160.9 71.8 89.9 96.9 96.9 121.1 142.76462114842 -0.222992382482092 0.272212076135478 -0.81918622291801 0.412680174050605 0.901158530199572 Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.D.3 - Serine family Rv0816c thiX 23 5.9 0.5 18.7 14.7 3.3 5.60102556738763 0.222890625543103 1.04789637361036 0.21270292669796 0.831558683827531 NA Probable thioredoxin ThiX I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv0817c - 19.6 6.4 7.6 13.4 4.9 7 11.8379031364642 -0.563050162388472 0.655784229400205 -0.858590580782112 0.390566436599713 NA Probable conserved exported protein II.C.5 - Other membrane proteins Rv0818 - 295 169.9 126 255.4 178.8 111.8 227.698687308692 -0.265378166253188 0.237787849450731 -1.11602912792302 0.264409666652382 0.80816433845196 Transcriptional regulatory protein I.J.2 - Two component systems Rv0819 mshD 147.2 91.1 92.3 141.1 152.4 56.1 171.007765494419 -0.129617085055574 0.272350561835303 -0.475920020807435 0.634131358236976 0.934597866696866 GCN5-related N-acetyltransferase, MshD V - Conserved hypotheticals Rv0820 phoT 155.2 96.8 78.8 125 131.1 96.2 140.790099185847 -0.0842849725741317 0.232698859372999 -0.362206212790364 0.717197937194862 0.949890877982223 Probable phosphate-transport ATP-binding protein ABC transporter PhoT III.A.4 - Anions Rv0821c phoY2 1405.5 970.1 727.3 1095.7 1389.1 1014.1 1133.35852326114 -0.0023803083322713 0.18306728423536 -0.0130023687313298 0.989625903046455 0.999120249206713 Probable phosphate-transport system transcriptional regulatory protein PhoY2 III.A.4 - Anions Rv0822c - 663.1 429.9 371.1 387.2 503.6 345.7 1500.53267715607 -0.431084891770915 0.183884175555612 -2.34432838208279 0.0190613805559598 0.288108079878605 hypothetical protein V - Conserved hypotheticals Rv0823c - 1786.2 1093.6 934.2 1258.5 1219.3 870.2 2242.75569474085 -0.370598405476805 0.159074655449753 -2.32971370850378 0.0198212875221447 0.292510047017054 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0824c desA1 5416.9 4511.9 2805.4 4301.1 5193.4 4771.8 7419.00839016851 -0.00758142947953793 0.198242309870405 -0.0382432462802419 0.969493740553248 0.998153412295216 Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) I.H.2 - Modification of fatty and mycolic acids Rv0825c - 19.7 19.7 9.2 7.8 10.7 6.6 12.5668751986425 -1.19842771063156 0.636040170798309 -1.88420129050558 0.059537753068293 NA hypothetical protein V - Conserved hypotheticals Rv0826 - 9.3 6.7 1.8 6.8 5.5 2.7 7.84284113360265 -0.290742325262239 0.789687022228403 -0.368174120985043 0.712743405608112 NA hypothetical protein V - Conserved hypotheticals Rv0827c kmtR 127.6 54.5 76.4 115.9 108.5 97.2 59.9821183628795 0.117154377421209 0.322041832042376 0.363786209630657 0.716017661230084 0.949890877982223 Metal sensor transcriptional regulator KmtR (ArsR-SmtB family) I.J.1 - Repressors/activators Rv0828c - 8.1 4.5 0.9 2.5 16.9 6.7 3.34218292001722 0.886169109095163 1.259174490661 0.703769902954413 0.481576079692988 NA Possible deaminase V - Conserved hypotheticals Rv0829 - 11.5 0 0 9.2 12.7 17.8 3.5654070350019 1.47058857583025 1.25400412010968 1.17271430950452 0.24091039113262 NA Possible transposase (fragment) IV.B.1.c - Others Rv0830 - 66.7 29.3 17.3 52.3 41 66.4 63.5236237042371 0.38431052376162 0.355943066474219 1.07969661431642 0.280277302078882 0.822522870982296 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0831c - 491.5 403 280.3 295.9 536.4 491.5 556.103803692907 -0.00153643998588344 0.261601849608401 -0.0058732000105633 0.995313891329892 0.999833281786427 hypothetical protein V - Conserved hypotheticals Rv0832 PE_PGRS12 82.2 46 19.4 65.1 53.2 66.4 34.9984301528242 0.19819867709543 0.412575982401181 0.480393153139742 0.630947861956396 0.93413540068838 PE-PGRS family protein PE_PGRS12 IV.C.1.b - PE_PGRS subfamily Rv0833 PE_PGRS13 17.4 6.3 5.8 23.4 5 15 41.2312934277651 0.455627661093466 0.459349495010107 0.991897598762878 0.321247480597511 0.849868688356633 PE-PGRS family protein PE_PGRS13 IV.C.1.b - PE_PGRS subfamily Rv0834c PE_PGRS14 36.3 9.8 17.6 25.9 21.3 11.8 83.7428223880712 -0.270812587105091 0.334124122965349 -0.810514920927083 0.417644292947138 0.901158530199572 PE-PGRS family protein PE_PGRS14 IV.C.1.b - PE_PGRS subfamily Rv0835 lpqQ 45 42.2 26.1 22.8 63.8 57.3 44.9634183055155 0.110231364786203 0.437420699934743 0.252003082621942 0.801038681095452 0.965592404376002 Possible lipoprotein LpqQ II.C.1 - Lipoproteins(lppA-lpr0) Rv0836c - 2.8 0.8 6.4 1.4 0 0.2 2.07219513152735 -2.64792542674861 1.71917285033126 -1.54023222635141 0.123503757193464 NA Hypothetical protein VI - Unknowns Rv0837c - 5.2 6.6 1.9 2.3 5.1 5.5 6.93288357561264 -0.418515822634816 0.844449866970068 -0.495607660092923 0.620171247284309 NA Hypothetical protein VI - Unknowns Rv0838 lpqR 33.9 15.8 13.6 23.5 37.6 29.5 30.4976548033598 0.328761860245825 0.427314239098096 0.769367903442022 0.441674936970133 0.901158530199572 Probable conserved lipoprotein LpqR II.C.1 - Lipoproteins(lppA-lpr0) Rv0839 - 247.7 105.6 120.5 102 141.2 93.5 175.150177046235 -0.673627906190833 0.252096193775497 -2.67210661177506 0.007537669640862 0.173743285221869 hypothetical protein V - Conserved hypotheticals Rv0840c pip 36.6 30.1 22.1 14.3 17.8 6.9 29.8525482864499 -1.4066564700415 0.440428972377987 -3.1938327364038 0.001403974378936 0.0611725004333888 Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap) II.B.3 - Proteins, peptides and glycopeptides Rv0841 - 6.9 7.1 4.4 4.3 6.3 0 1.40039716250012 -0.637938358598971 1.69286157014172 -0.376840238948519 0.706292335093968 NA Probable conserved transmembrane protein ? Rv0842 - 8.8 7.5 5.8 10.5 4.3 6.4 14.4404483179068 -0.222814708074436 0.583331126684769 -0.381969515909006 0.702483976106926 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0843 - 11.5 9.5 3.2 7.1 11.1 10.2 13.8346902489422 0.0563116509661443 0.602419084959542 0.0934758748055371 0.925525514881023 NA Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0844c narL 136 105.2 62.9 156.7 166.5 67.9 117.775479674851 0.201664997717431 0.280423953382238 0.719143266062392 0.472052651464252 0.904222738192604 Possible nitrate/nitrite response transcriptional regulatory protein NarL I.J.2 - Two component systems Rv0845 - 14.9 8.9 3.4 13.3 5.8 9.3 17.5758594209644 0.0202067720993302 0.556877071649755 0.0362858755155198 0.971054412229532 NA Possible two component sensor kinase I.J.2 - Two component systems Rv0846c - 5.7 2.5 2.7 7.2 5.3 11.8 13.5411405084907 0.961560069743737 0.61738288409066 1.55747769256677 0.119357112827022 NA Probable oxidase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0847 lpqS 38.3 14.9 7.8 35.8 29.2 24 13.9837946607015 0.450097177304767 0.602075308737728 0.747576209774175 0.454715818888594 NA Probable lipoprotein LpqS II.C.1 - Lipoproteins(lppA-lpr0) Rv0848 cysK2 21.2 12.9 2.9 7.3 7.6 4.8 15.7872794228364 -1.04930888003711 0.60431356830782 -1.73636491892008 0.0824993310887462 NA Possible cysteine synthase a CysK2 (O-acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSASE) I.D.3 - Serine family Rv0849 - 2.5 1.2 0 0.6 1.5 0 1.37878274753814 -1.13934709376926 1.81277602282187 -0.628509578362409 0.529670173955815 NA Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv0850 - 4 8.5 0 2.4 1 0 1.06546328868444 -1.5664555879727 2.10333313216923 -0.744749162182008 0.45642337305776 NA Putative transposase (fragment) IV.B.1.c - Others Rv0851c - 10.5 5.7 3.9 16.9 13.4 0.3 10.125470428079 0.557816370507383 0.729522158477034 0.764632525586189 0.44449039546009 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0852 fadD16 7.4 7.2 6.4 9.7 17.9 10.1 12.7440045298658 0.69482572166361 0.62345099022395 1.11448330752353 0.265071901671922 NA Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0853c pdc 21.4 7.9 5.4 15.3 16.4 24.4 39.0005466069862 0.556140804202144 0.426259172161399 1.30470108451195 0.191994652059777 0.741700010610815 Probable pyruvate or indole-3-pyruvate decarboxylase Pdc I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0854 - 63.5 38.2 47.4 51.6 51 60.1 37.2716111401533 -0.121325454703181 0.390646109516044 -0.310576380380407 0.756122685514071 0.959593750764785 hypothetical protein V - Conserved hypotheticals Rv0855 far 21.6 8.7 9.8 24.3 37.2 14.3 31.8022399752235 0.739420812431659 0.424397612454468 1.74228315789828 0.0814589090030592 0.560485926125527 Probable fatty-acid-CoA racemase Far I.A.3 - Fatty acids Rv0856 - 196.6 152.3 154.8 131.9 221.8 230.2 121.522005156731 -0.0276230493633523 0.317969865643719 -0.0868731673909741 0.930772328185858 0.998010361628995 hypothetical protein V - Conserved hypotheticals Rv0857 - 196.3 59.4 89.7 145.8 152.8 125.7 95.007556987865 0.132700270686529 0.298051912755285 0.445225361782807 0.656156900298304 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv0858c dapC 16.3 10.1 14.5 16.1 7.7 4.7 22.1752940680167 -0.673162156528563 0.521761145419339 -1.29017302732947 0.196990588937538 NA Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at) IV.H - Miscellaneous transferases Rv0859 fadA 197.2 140.6 141.1 96.1 97.5 86.8 256.035251785227 -1.00656869752934 0.227516244875538 -4.42416187942965 9.6817405955641e-06 0.00107118777949321 Possible acyl-CoA thiolase FadA I.A.3 - Fatty acids Rv0860 fadB 257.9 168.3 169.8 162.9 127.5 115.2 594.45537009732 -0.7686572457271 0.196350187848037 -3.91472630686757 9.05068136931213e-05 0.00641902170961983 Probable fatty oxidation protein FadB I.A.3 - Fatty acids Rv0861c ercc3 123.5 94.2 55.7 105 85.1 72 232.342969430735 -0.218673022569804 0.217754432560655 -1.00421846755699 0.315273322530316 0.847340730510678 DNA helicase Ercc3 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0862c - 40.4 25.2 17.6 34.4 30.6 14 95.6842521741149 -0.224057010484797 0.286828685753742 -0.781152728486726 0.43471267267964 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0863 - 703.1 452.2 272 574.8 571.6 592.5 235.659967428618 0.144727286231526 0.223856498378318 0.646518136752665 0.517943855242834 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv0864 moaC2 683 489.2 368.8 454 549 404.9 400.716772759094 -0.317247128108541 0.198690119850212 -1.59669302302353 0.110334151642867 0.646919977351541 Probable molybdenum cofactor biosynthesis protein C 2 MoaC2 I.G.4 - Molybdopterin Rv0865 mog 272 153.9 148.7 170.4 181.5 173 142.704443566336 -0.318212308394029 0.242829530793917 -1.31043496791207 0.190048730683027 0.739746500217031 Probable molybdopterin biosynthesis Mog protein I.G.4 - Molybdopterin Rv0866 moaE2 177 97.2 99.3 164 85.2 62.4 76.8515946954932 -0.422328160990189 0.327464429345566 -1.28969171349147 0.197157717845874 0.751109817915875 Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) I.G.4 - Molybdopterin Rv0867c rpfA 75.1 36.4 31.3 129.9 131.9 87.7 154.056227799351 1.13453702851195 0.237010107610419 4.78687191846193 1.69400865613615e-06 0.00022312514013679 Possible resuscitation-promoting factor RpfA II.C.5 - Other membrane proteins Rv0868c moaD2 385.8 350.5 224.7 163.2 325.2 342 138.01887682638 -0.415697209755366 0.327189476483188 -1.27050910751625 0.203903340765321 0.764223090185471 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) I.G.4 - Molybdopterin Rv0869c moaA2 229 134.7 98.8 167.4 184 102.9 260.393041382843 -0.1851650504563 0.213927545921016 -0.865550294886591 0.3867368234007 0.893826103932853 Probable molybdenum cofactor biosynthesis protein A2 MoaA2 I.G.4 - Molybdopterin Rv0870c - 324.2 207.7 185.5 179.5 261.6 192.5 142.545916855831 -0.382805942766832 0.257867788203055 -1.48450469690071 0.137675078029454 0.682181933169668 Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv0871 cspB 215.1 133.1 95.7 205 194.7 169.7 108.124790653586 0.194109064316674 0.25118549915978 0.772771776101616 0.439657459601284 0.901158530199572 Probable cold shock-like protein B CspB III.E - Adaptations and atypical conditions Rv0872c PE_PGRS15 116.5 56.2 85.1 96 63.6 50.7 231.14513181442 -0.514059045306859 0.265720789657262 -1.93458346247546 0.0530414310154982 0.477891199312273 PE-PGRS family protein PE_PGRS15 IV.C.1.b - PE_PGRS subfamily Rv0873 fadE10 169.9 108.2 91.5 152.1 152 151.5 431.39684326698 0.127045823279835 0.194300483750781 0.653862619522808 0.513200318651254 0.915911629458156 Probable acyl-CoA dehydrogenase FadE10 I.A.3 - Fatty acids Rv0874c - 21.8 9.3 13.9 16.4 17.9 12.4 27.9055186714108 -0.184769959880251 0.431800286996869 -0.427906060844259 0.668719514316205 0.940354944889996 hypothetical protein V - Conserved hypotheticals Rv0875c - 113.8 56 59.4 56.4 80.5 43.7 52.92855410249 -0.554427143542228 0.34085637993144 -1.62657111964208 0.103828217216972 0.635373559341028 Possible conserved exported protein II.C.5 - Other membrane proteins Rv0876c - 105.1 57.8 40.7 80.3 58.4 60 173.706671894652 -0.171663428984987 0.2322155160619 -0.739241855566739 0.459760149146229 0.901158530199572 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0877 - 192.4 138.1 107.8 177.2 124 141.4 187.010501536983 -0.168572760880048 0.230734040967145 -0.730593371370165 0.465027562055638 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv0878c PPE13 10.8 13.9 16.9 12.4 14.6 18 32.9046724576121 -0.208419435504129 0.485027762885123 -0.429706197155341 0.667409374869464 0.940354944889996 PPE family protein PPE13 IV.C.2 - PPE family Rv0879c - 84.1 67.6 44.2 82.5 74.3 80.8 31.9662645572895 0.0839875380383612 0.401985491481971 0.208931764499088 0.834501506854912 0.970252697755647 Possible conserved transmembrane protein VI - Unknowns Rv0880 - 13.5 3.9 8.7 12.3 3 6.6 4.72305319325518 -0.375708477564006 1.00137417535881 -0.375192896730518 0.707517012580303 NA Possible transcriptional regulatory protein (possibly MarR-family) V - Conserved hypotheticals Rv0881 - 7.5 0.3 3.1 7.3 6.4 6.5 6.5151127527861 0.62719354202014 0.8659794652301 0.724259139162714 0.468906657485008 NA Possible rRNA methyltransferase (rRNA methylase) IV.H - Miscellaneous transferases Rv0882 - 14.4 22.2 12.4 7.5 0 0 4.54537696503672 -2.40875445131863 1.19138539246885 -2.02180962310364 0.043196023242418 NA Probable transmembrane protein II.C.5 - Other membrane proteins Rv0883c - 80.9 59.7 37.2 69.1 67.2 92.9 83.0597722055881 0.18115342014406 0.304140682752997 0.59562377023787 0.551426593403364 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv0884c serC 117.7 98.7 69.2 101 120.6 105.3 187.330538275282 0.0038013382072108 0.239861847137729 0.015848031909085 0.987355629316445 0.999120249206713 Possible phosphoserine aminotransferase SerC (PSAT) I.D.3 - Serine family Rv0885 - 63.7 33.4 26.7 32.3 41.4 36.4 62.875270416631 -0.371460336914943 0.31685639249725 -1.17233025973483 0.241064487250291 0.78958848015113 hypothetical protein II.C.5 - Other membrane proteins Rv0886 fprB 21.5 9 8 19.7 16.1 3.3 33.5587882516023 -0.0858007287554716 0.450094463295467 -0.190628269735341 0.848816840278393 0.975474031954732 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) I.B.6.c - Electron transport Rv0887c - 4.1 3.8 0 3.6 12.1 6.5 2.90968307068845 1.44945526435737 1.28660664738631 1.1265721868466 0.259923404023806 NA hypothetical protein VI - Unknowns Rv0888 - 16.4 13 6.1 16.3 26.1 20.2 37.4674407570421 0.638476920844078 0.398419000156037 1.60252628663298 0.109039279481814 0.643080319504058 Probable exported protein II.C.5 - Other membrane proteins Rv0889c citA 200.2 108.8 116.3 187 149.2 107.1 258.937155186201 -0.128162788616969 0.218123663598775 -0.587569392987625 0.556821359995824 0.92521033104044 Probable citrate synthase II CitA I.B.3 - TCA cycle Rv0890c - 32.3 21.9 13.5 49.4 49 39.1 140.706233140718 0.868673449129966 0.237542870982157 3.65691231034762 0.000255271658972524 0.0160473047435909 Probable transcriptional regulatory protein (probably LuxR-family) I.J.1 - Repressors/activators Rv0891c - 29.4 25.3 11.9 15.2 47.4 17.8 32.9462655356959 0.0895615323219624 0.473616776626503 0.18910126655541 0.850013448828538 0.975474031954732 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0892 - 20.6 19.7 7.9 40 32.1 29.2 57.5319078608944 0.952054419964481 0.335437667353419 2.83824541076775 0.0045362290660297 0.129352676254001 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0893c - 31 16.5 9.8 39 43.6 31 42.1791503646018 0.826039715884363 0.364163860340356 2.26831875934182 0.0233097853535458 0.319182506375781 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0894 - 3.3 2.3 0.5 6.3 7.3 7.5 7.47153530246471 1.80604343672519 0.839249330921779 2.1519748305805 0.0313993367747064 NA Possible transcriptional regulatory protein (possibly LuxR-family) I.J.1 - Repressors/activators Rv0895 - 4.3 2.3 2.8 3.3 5.4 4.8 8.86031772247782 0.276293985511861 0.715902060474533 0.385938245978395 0.699542404619038 NA Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv0896 gltA2 554.8 434.7 297.9 352.6 402.8 393 858.670488677303 -0.343605226584621 0.200855750473811 -1.71070644367448 0.0871353175916474 0.571128645636248 Probable citrate synthase I GltA2 I.B.3 - TCA cycle Rv0897c - 75.1 54.6 38.1 55 49.8 49.2 138.82661697882 -0.300331618628711 0.239279812613061 -1.25514816878587 0.209424977083835 0.770341510876847 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0898c - 450.3 320.4 279 380.9 568.7 408 170.559625812502 0.16636950000857 0.253344573259637 0.65669257433854 0.511378610076989 0.915911629458156 hypothetical protein VI - Unknowns Rv0899 ompA 42.8 29.3 28.8 34.5 63.1 43.4 63.3454011413512 0.265051561807761 0.343661754852968 0.771257080733816 0.440554566555354 0.901158530199572 Outer membrane protein A OmpA II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0900 - 80.6 34.8 35.9 109.2 97.8 85.7 16.8994114308382 0.749287366275841 0.523953832101694 1.43006372006153 0.152698731669095 NA Possible membrane protein VI - Unknowns Rv0901 - 95.6 45.9 40.5 118.6 86.3 55.9 59.7307765609423 0.382137129990041 0.325200645779452 1.17508109208739 0.239962274446351 0.78958848015113 Possible conserved exported or membrane protein V - Conserved hypotheticals Rv0902c prrB 95.8 52.7 55.2 57.5 65.7 60.4 140.054765589198 -0.357690904059589 0.249524807048325 -1.43348835048019 0.151718325748322 0.699421481699767 Two component sensor histidine kinase PrrB I.J.2 - Two component systems Rv0903c prrA 145.3 86.7 57.1 161 101.1 74.5 114.768084527143 0.0892927573700441 0.275363002868515 0.324272892290767 0.745731440625473 0.956095160416489 Two component response transcriptional regulatory protein PrrA I.J.2 - Two component systems Rv0904c accD3 6.3 2.7 1.4 9.2 2.5 1.9 7.98337020425496 0.356916893381932 0.826046007600801 0.432078710020735 0.665684207662619 NA Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain) I.H.1 - Synthesis of fatty and mycolic acids Rv0905 echA6 194.4 121.8 78.1 211.9 192 96.6 168.779662636405 0.195434965149046 0.249985984449504 0.78178368911127 0.434341708384249 0.901158530199572 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0906 - 95.1 38.9 34.4 79.8 51.7 53.4 101.887510457396 0.0173952229259847 0.283202359920906 0.0614232979232339 0.951022098328402 0.998153412295216 hypothetical protein II.C.5 - Other membrane proteins Rv0907 - 83.6 31.9 53.2 62.2 63.8 65.9 155.203617328613 -0.0106236312828536 0.277515264787625 -0.0382812501899078 0.96946344000859 0.998153412295216 hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv0908 ctpE 88.9 54.5 44 73.3 58 51.7 235.432927715537 -0.201398851941802 0.206184271678116 -0.976790568468848 0.328672846269769 0.853347384539607 Probable metal cation transporter ATPase P-type CtpE III.A.2 - Cations Rv0909 - 497 293.2 280.3 249.3 443 348.8 102.67457850423 -0.253232296084129 0.300812452986424 -0.841827835151351 0.399884328908258 0.893826103932853 hypothetical protein VI - Unknowns Rv0910 - 294 220.4 113.3 283.4 253.5 231.2 159.577037048778 0.151353683073806 0.240954159254073 0.628143060664964 0.529910226652782 0.922751607774049 hypothetical protein V - Conserved hypotheticals Rv0911 - 59.9 57.7 23.1 69.4 68 35.9 63.1539838403286 0.166210073265186 0.338499724846469 0.491019817935075 0.623412430835369 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv0912 - 28.5 17.3 7.1 33.3 22.8 27.1 15.4566435274544 0.535467588190742 0.557172431618925 0.961044656561493 0.336529714753403 NA Probable conserved transmembrane protein V - Conserved hypotheticals Rv0913c - 81.8 62.6 55 62.4 94.5 92.7 185.045233489024 0.110467465892939 0.273657544973467 0.403670455728342 0.686455067950162 0.942913432418385 Possible dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0914c - 88 73.2 45.1 73.4 63.4 61.1 134.173204289365 -0.236917045103789 0.248590783782348 -0.953040340028133 0.340569632023194 0.855368447926409 Possible lipid carrier protein or keto acyl-CoA thiolase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0915c PPE14 7.9 2.7 5.1 7.8 7.3 2.2 10.3669395282617 -0.100956982698682 0.687160935166035 -0.146918978556732 0.883195971754516 NA PPE family protein PPE14 IV.C.2 - PPE family Rv0916c PE7 14.9 29.6 10.2 17.5 6 8.3 6.48745691066709 -0.969234971839036 0.90877523241998 -1.06652881511533 0.28618466005158 NA PE family protein PE7 IV.C.1.a - PE subfamily Rv0917 betP 17.6 11.7 6.8 15 18.6 19.1 41.6120859836986 0.388548678239091 0.374904440930477 1.03639390687064 0.300018411816822 0.84163380028938 Possible glycine betaine transport integral membrane protein BetP III.A.1 - Amino acids Rv0918 - 23.3 22.8 2.9 13.3 29.4 12.8 12.18892251781 0.0107210408435855 0.681289774361862 0.0157363889009306 0.987444696441835 NA hypothetical protein V - Conserved hypotheticals Rv0919 - 11.7 6 5.8 9.6 8.9 20.8 8.00356950822288 0.605951490366305 0.781067035955922 0.77579959526099 0.437867322976121 NA GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv0920c - 34.2 24.2 16.8 23 26.6 22.3 51.4155111753679 -0.254085158504867 0.331667509539576 -0.766083958171213 0.44362634745463 0.901158530199572 Probable transposase IV.B.1.c - Others Rv0921 - 48.3 44.2 26.8 70.2 61.8 51.7 46.1065031844465 0.470595513208042 0.348628043644586 1.34984985226202 0.177064150143817 0.734764437650925 Possible resolvase IV.B.1.c - Others Rv0922 - 209.1 116.5 101 158.1 206.7 129.2 401.6046710928 0.0431191295767885 0.203078413356751 0.21232748899333 0.831851551197004 0.969617105187911 Possible transposase IV.B.1.c - Others Rv0923c - 12 13 5 12.3 8.7 9.8 17.0077619863896 -0.0848021215498198 0.540838068935452 -0.156797619140861 0.875404349292922 NA hypothetical protein VI - Unknowns Rv0924c mntH 9.1 1.8 3 12.6 9.7 8.1 14.1222735468603 0.953284056178258 0.599635544966073 1.58977242790401 0.111886110985234 NA Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) III.A.2 - Cations Rv0925c - 76.1 39.8 36.2 45.7 81.6 66.3 67.164217658183 0.145647097961158 0.335518633987534 0.434095406953076 0.664219160696705 0.939759692320761 hypothetical protein VI - Unknowns Rv0926c - 33.6 34.6 24.4 30.8 38.9 55 64.0234190021019 0.188556077048388 0.366498006569988 0.514480498306287 0.606916091563563 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv0927c - 26.1 14.2 10.4 22.3 11.3 27.3 22.6681657459133 0.110104276190049 0.487005626255189 0.226084197500327 0.821135934983738 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0928 pstS3 43.5 46.2 32.6 42.6 41.4 47.8 77.7019026700222 -0.115557604878959 0.320456723420963 -0.36060284098692 0.718396365229858 0.949890877982223 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) III.A.4 - Anions Rv0929 pstC2 30.9 7.6 14.8 34.1 38.2 27.6 37.8355611381146 0.687517090166842 0.399475358089714 1.72105006289885 0.0852417397942821 0.565416432304519 Phosphate-transport integral membrane ABC transporter PstC2 III.A.4 - Anions Rv0930 pstA1 35.2 23.6 15 44.7 31.2 26 42.1428353153967 0.342084987519553 0.359329235925587 0.952009893206669 0.341091964539116 0.855368447926409 Probable phosphate-transport integral membrane ABC transporter PstA1 III.A.4 - Anions Rv0931c pknD 1055.3 605.8 593.9 620.1 788.2 646.1 2323.03425886094 -0.305901621369655 0.187718492927385 -1.62957637577021 0.103191060733815 0.634281053310518 Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0932c pstS2 2376.8 1545.2 1142.2 1184.7 1704.5 1443.5 2820.38401269428 -0.371043000819674 0.201125140473727 -1.84483650301363 0.0650613256671236 0.514454587842348 Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2) III.A.4 - Anions Rv0933 pstB 87 73.5 50.7 113 88.4 78.3 108.70667854596 0.229484733791523 0.264076280037761 0.869009264136517 0.384842063638608 0.893826103932853 Phosphate-transport ATP-binding protein ABC transporter PstB III.A.4 - Anions Rv0934 pstS1 113.4 77 73.8 105.7 101.5 107.6 176.492575887965 0.0502986245518937 0.238511241365009 0.210885760620895 0.832976415642252 0.969702342452218 Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1) III.A.4 - Anions Rv0935 pstC1 144.4 82.8 69.4 197.8 148 164 215.040606728216 0.624098794328749 0.218605690446018 2.85490644390551 0.00430495082978337 0.124036395783133 Phosphate-transport integral membrane ABC transporter PstC1 III.A.4 - Anions Rv0936 pstA2 62.2 40.5 18 103.4 67.4 75.1 85.1835902080465 0.922706574486598 0.304028204090265 3.03493742380773 0.00240585598156215 0.0831824705625113 Phosphate-transport integral membrane ABC transporter PstA2 III.A.4 - Anions Rv0937c mku 166.7 120.9 92.6 143.3 163.1 194.9 195.705916901989 0.213963841774254 0.252938905388448 0.845911155682678 0.397602308720688 0.893826103932853 DNA end-binding protein, Mku V - Conserved hypotheticals Rv0938 ligD 222.3 161.5 129.2 178.8 185 147.7 630.391509624553 -0.199107508297925 0.181669980953436 -1.09598463792958 0.27308549731344 0.813286748879977 ATP dependent DNA ligase LigD (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase) V - Conserved hypotheticals Rv0939 - 194.3 88.5 94.3 159.5 131.6 92.9 386.136020608558 -0.136081549727898 0.207339302011006 -0.656322985599106 0.511616331211735 0.915911629458156 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase II.B.6 - Aromatic hydrocarbons Rv0940c - 52.2 34.2 21.3 30.1 33.5 9.8 40.8038989011968 -0.657093574185316 0.385010017023106 -1.70669215119637 0.0878792868264893 0.571985071522678 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0941c - 46.4 31.5 23.7 23.2 30.8 22.8 36.7198440204052 -0.616697911897008 0.383324826722574 -1.6088128628917 0.107657267407683 0.643080319504058 hypothetical protein VI - Unknowns Rv0942 - 1.1 0 0 0.2 0 0 0.0448007840762574 -0.318231606298853 4.0267484609073 -0.0790294227186839 0.937009220301446 NA Hypothetical protein VI - Unknowns Rv0943c - 4.2 0 0 0.8 4.1 8.2 4.33255179779914 1.34582609134863 1.28223922863598 1.04959048303357 0.293906434505905 NA Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0944 - 35.6 26.6 34 53.1 42.6 65.3 33.4354396973756 0.498646530233306 0.430205631440614 1.15908880263493 0.246419989610437 0.791634949201473 Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0945 - 45.9 39.8 27 51.2 48.5 37.2 50.2451666536243 0.111375426730043 0.337051186169843 0.330440690613443 0.741066999917256 0.955781054558401 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0946c pgi 41.1 27.2 23.6 35.3 33.3 27.4 83.0179923188858 -0.117877103373261 0.27542276269938 -0.427986061202656 0.668661268582643 0.940354944889996 Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) I.B.1 - Glycolysis Rv0948c - 136.7 101.3 45.4 161.5 103.1 65.7 49.9057993615434 0.113834489521498 0.366854771476636 0.310298511488074 0.756333962992391 0.959593750764785 Chorismate mutase VI - Unknowns Rv0949 uvrD1 68.4 37.6 32.9 55.7 50.4 34.2 170.080652938831 -0.148919050388135 0.225086621421483 -0.661607737713026 0.508222647304829 0.915911629458156 Probable ATP-dependent DNA helicase II UvrD1 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0950c - 102.2 76.2 45.9 114.6 96.8 103.4 142.128243571507 0.330374410110605 0.242937125994506 1.35991733975678 0.17385608316381 0.732826269155182 hypothetical protein V - Conserved hypotheticals Rv0951 sucC 342.7 220.3 175.2 225.8 235.5 229.3 447.753057999617 -0.266036642296963 0.193414973937661 -1.37547076568492 0.168985543023801 0.725798155285455 Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta) I.B.3 - TCA cycle Rv0952 sucD 291.2 183.1 135.9 254.4 250.3 179.5 311.253793902028 0.000486094893264618 0.192999278556121 0.00251863580476167 0.997990421501731 0.999833281786427 Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) I.B.3 - TCA cycle Rv0953c - 12.6 0 3.7 9.9 8.5 9.8 8.61578353035299 0.551584900870696 0.801352095385708 0.68831778695881 0.491252683111027 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0954 - 204.9 104.4 83 207.2 153 159.9 216.625961855895 0.264607909522705 0.220776483606127 1.1985330375801 0.230709569284558 0.784923331661854 Probable conserved transmembrane protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0955 - 91.2 53.2 35.3 95.8 61.2 81 149.638238721812 0.269985908227415 0.253849199635053 1.06356808930483 0.287524404704345 0.829758572569927 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0956 purN 31.9 20.4 18.7 21.6 19.7 3.1 19.3231489723802 -0.770525982473203 0.531391235565868 -1.45001635499819 0.147053958500053 NA Probable 5'-phosphoribosylglycinamide formyltransferase PurN (GART) (gar transformylase) (5'-phosphoribosylglycinamide transformylase) I.F.1 - Purine ribonucleotide biosynthesis Rv0957 purH 56.8 27.9 24.2 39.4 49.8 33.3 94.6419733479612 -0.00741853919008363 0.27397275795594 -0.0270776527032541 0.978397798783925 0.998567088804884 Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC) I.F.1 - Purine ribonucleotide biosynthesis Rv0958 - 47 37.6 19.8 59.8 48.2 29.4 86.5113286763632 0.254031882172697 0.294104794349804 0.863746144411897 0.387727358647233 0.893826103932853 Possible magnesium chelatase IV.K - Chelatases Rv0959 - 42.1 19.6 16.7 46.4 37.5 25.7 97.2521248169384 0.342551022535876 0.274387638735723 1.24842002400044 0.211877279750281 0.773070552038584 hypothetical protein VI - Unknowns Rv0959A vapB9 335.8 135.6 157.8 288 155.7 98.2 67.0146639472385 -0.354240580113753 0.350510231213948 -1.0106426248583 0.312187506977506 0.846061021823653 Possible antitoxin VapB9 ? Rv0960 vapC9 316.2 110 102.9 226.2 160.4 116.1 100.305593205505 -0.171792966706108 0.301358025399772 -0.570062690310679 0.568635179235247 0.92521033104044 Possible toxin VapC9 V - Conserved hypotheticals Rv0961 - 238.4 145.3 116.3 192.9 228.6 145.5 97.1552080118005 0.00646254755347221 0.264624614222045 0.0244215662721742 0.980516346057146 0.998567088804884 Probable integral membrane protein VI - Unknowns Rv0962c lprP 2.4 0 1.6 0.8 1.2 0 0.648825392029585 -1.57228935909369 2.48542147782434 -0.632604720415477 0.526991803761187 NA Possible lipoprotein LprP VI - Unknowns Rv0963c - 8.6 2.2 4 7.2 6.9 18.2 9.63350809283626 0.866587017826441 0.752571004298971 1.15150200163993 0.249525772255607 NA hypothetical protein V - Conserved hypotheticals Rv0964c - 21.7 10.7 12.8 25.6 20 12.1 12.4728957303242 0.159134813313785 0.603597572184151 0.263643892300538 0.792054333555078 NA Hypothetical protein VI - Unknowns Rv0965c - 56.6 40.5 33.9 55.1 31.3 23.9 26.343901448776 -0.430338603401584 0.455692566660672 -0.944361692259143 0.344984850218366 NA hypothetical protein V - Conserved hypotheticals Rv0966c - 141.9 60.2 38.1 100.7 117.5 78.9 82.1360534254963 0.190378696276285 0.309254937533942 0.615604387093709 0.538155655103026 0.924361123608528 hypothetical protein V - Conserved hypotheticals Rv0967 csoR 87.3 75.9 91 174.9 184.3 128.8 71.4034270771933 0.703662503132562 0.333953317289465 2.10706846347221 0.0351116454896764 0.39160811058244 Copper-sensitive operon repressor CsoR V - Conserved hypotheticals Rv0968 - 108.5 70.5 48.3 133.3 76.3 65.2 38.5056978848215 0.146706702251776 0.383535338473317 0.382511564216613 0.70208195288716 0.947279830180307 hypothetical protein V - Conserved hypotheticals Rv0969 ctpV 39.7 20.3 15.4 43.1 24 15.3 93.1641162581906 0.00412897963196125 0.313988349823677 0.0131501045636882 0.989508036984116 0.999120249206713 Probable metal cation transporter P-type ATPase CtpV III.A.2 - Cations Rv0970 - 78.2 44.7 29.8 104.2 62 42 57.9524428478074 0.324272457917211 0.343783064101912 0.943247331756528 0.345554408515071 0.858763247037453 Probable conserved integral membrane protein VI - Unknowns Rv0971c echA7 22.1 11.5 1.3 9 5.2 0 9.1886166742416 -1.2346787727591 0.87313023331477 -1.41408317528044 0.157337482492895 NA Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0972c fadE12 35.1 22 20 7.4 11.8 15.4 35.6132551186994 -1.49750744760153 0.435097739111998 -3.44177253289763 0.000577915992411615 0.030740685288664 Acyl-CoA dehydrogenase FadE12 I.A.3 - Fatty acids Rv0973c accA2 25.2 8.5 20.8 10 8.3 7.9 44.6755671548023 -1.32603951856345 0.419651748999466 -3.15985700458773 0.00157846587694172 0.0651647256062806 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.A.3 - Fatty acids Rv0974c accD2 12.1 6.5 7.8 4.8 6.5 3.6 17.7081354597879 -1.08950590699639 0.535324892915627 -2.03522369576806 0.0418283698261958 NA Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 I.A.3 - Fatty acids Rv0975c fadE13 14 1.4 13.9 10.7 7.3 2.5 14.8629897750774 -0.784675930430169 0.713414615910323 -1.09988765709393 0.271381073210558 NA Probable acyl-CoA dehydrogenase FadE13 I.A.3 - Fatty acids Rv0976c - 7.7 6.5 5.1 2.9 4.4 7.7 15.4623417847824 -0.772328672469601 0.604122788360097 -1.27842996051531 0.201097865710459 NA hypothetical protein VI - Unknowns Rv0977 PE_PGRS16 13.1 10.1 5.7 9.4 8.1 13.3 44.1893115840967 -0.109736914009044 0.376371194510165 -0.291565655421274 0.770618737945973 0.961882413880217 PE-PGRS family protein PE_PGRS16 IV.C.1.b - PE_PGRS subfamily Rv0978c PE_PGRS17 0.7 0.9 1.1 0.6 0 2.8 0.975540794494662 -0.0912971611403991 2.12895877343307 -0.0428834800747113 0.96579441762638 NA PE-PGRS family protein PE_PGRS17 IV.C.1.b - PE_PGRS subfamily Rv0979c - 0.8 8.3 0 0.6 0 0 0.357547239656286 -1.17951763508709 3.40894556175219 -0.346006591692481 0.729337760914263 NA Hypothetical protein VI - Unknowns Rv0979A rpmF 305.6 116.1 144 151.3 152.5 145.4 45.7662475170528 -0.545893472523841 0.359057498219355 -1.52035112824839 0.128422750377748 0.671582561030228 50S ribosomal protein L32 RpmF ? Rv0980c PE_PGRS18 1.9 0 0.8 1 2.8 0 1.85415537534869 0.358992129268931 1.5601792274292 0.230096724118333 0.818016610382403 NA PE-PGRS family protein PE_PGRS18 IV.C.1.b - PE_PGRS subfamily Rv0981 mprA 288.9 133.2 179.2 252.1 270 219.3 246.038865350115 0.103967278575745 0.232114649330887 0.447913472395861 0.654215644938114 0.939577115195416 Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) I.J.2 - Two component systems Rv0982 mprB 353.9 183.9 195.3 272.5 237.8 232.4 598.77278177346 -0.153852030010153 0.189760925121672 -0.810767706320494 0.417499083108669 0.901158530199572 Two component sensor kinase MprB I.J.2 - Two component systems Rv0983 pepD 304.5 168.9 138.7 219.2 217.7 172.1 450.190173119109 -0.162687258890213 0.180800443273984 -0.899816703677424 0.368217803634841 0.883373818299354 Probable serine protease PepD (serine proteinase) (MTB32B) II.B.3 - Proteins, peptides and glycopeptides Rv0984 moaB2 356 161 152 354 233.8 131.6 195.424287694197 -0.0422330011596839 0.265264683802925 -0.159210794871813 0.873502799266819 0.979371196907994 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) I.G.4 - Molybdopterin Rv0985c mscL 21.5 18.8 8.5 22.9 11.8 43.7 15.0918360317856 0.434963997901841 0.617422021139753 0.704484101650445 0.481131347437362 NA Possible large-conductance ion mechanosensitive channel MscL II.C.5 - Other membrane proteins Rv0986 - 30.9 24.7 30.8 16.8 30.2 25.1 32.9997338754983 -0.552913654225564 0.45256061810875 -1.22174495990435 0.221804088416719 0.774556499980442 Probable adhesion component transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv0987 - 41.5 35.2 20.9 21.7 33.6 39.6 134.862562621792 -0.22613275616491 0.306111285643932 -0.738727275896477 0.460072619607669 0.901158530199572 Probable adhesion component transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv0988 - 60 41.2 39.1 59.4 78.6 63.2 106.372195749406 0.310930991625994 0.27555502781466 1.12838075970484 0.259159149849623 0.803279666631868 Possible conserved exported protein V - Conserved hypotheticals Rv0989c grcC2 7.4 14.1 0 7.9 24.1 2.9 13.6057054663355 0.47708317350372 1.54944149910704 0.307906541665929 0.758153447940724 NA Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0990c - 8.8 5.8 6.9 5.2 4.3 3.8 5.73638521319191 -1.03271594165418 0.897647234891297 -1.1504696962379 0.249950468538096 NA Hypothetical protein VI - Unknowns Rv0991c - 59 28.6 38.9 43.1 28.8 40.9 21.4506129135795 -0.394854270650774 0.488433842954952 -0.808408910123763 0.418855224365556 NA Conserved serine rich protein VI - Unknowns Rv0992c - 73.4 38.8 27.9 60.5 49.2 52.1 46.5053207574517 0.05994847216843 0.345332391600272 0.173596435279727 0.862182633719657 0.976768531807831 hypothetical protein V - Conserved hypotheticals Rv0993 galU 98.2 59.4 35.9 96.9 58.4 53.9 95.8356935039587 -0.00312704176720517 0.286230441727673 -0.0109249098325479 0.991283356510668 0.999476240744061 UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase) I.A.1 - Carbon compounds Rv0994 moeA1 136.4 76.8 43.6 163.8 75.9 53.2 178.919711408733 0.0683254929216568 0.306102884929415 0.223210875446052 0.823371388076235 0.967727711626973 Probable molybdopterin biosynthesis protein MoeA1 I.G.4 - Molybdopterin Rv0995 rimJ 49.9 30 47.9 67.7 44.3 73.6 52.194838361386 0.291705767812235 0.382520675138139 0.762588238418465 0.445709001143247 0.901158530199572 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) II.A.1 - Ribosomal protein synthesis and modification Rv0996 - 151.4 117.6 84.1 140.6 127 120.9 214.526518278381 -0.0469647062451842 0.218048343493476 -0.215386668354073 0.829465863208719 0.968638603196576 Probable conserved transmembrane protein VI - Unknowns Rv0997 - 108.7 99.8 49.1 130.4 92.7 47.5 59.7878465921456 -0.051997051477297 0.347479413275782 -0.149640667880456 0.881048121081984 0.980703859230131 Hypothetical protein VI - Unknowns Rv0998 - 65.3 40.8 19.8 55.5 42.1 38.5 67.3872436164234 0.000351847258550054 0.315550147268094 0.00111502802833783 0.999110336535678 0.999833281786427 hypothetical protein VI - Unknowns Rv0999 - 51.5 24.5 16.6 45.8 43.7 21.9 38.6782760140861 0.116646330347708 0.385800382475872 0.30234892355246 0.762386086761382 0.959593750764785 hypothetical protein VI - Unknowns Rv1000c - 150.6 44.5 62.1 85.9 90.2 37.7 74.1310800743904 -0.401171875690472 0.341798967163047 -1.17370710338953 0.240512364047319 0.78958848015113 hypothetical protein ? Rv1001 arcA 96.8 54.6 30.9 75.7 79.2 55.8 122.295990882075 0.0800354661383694 0.259659296393847 0.308232623479704 0.757905330168393 0.959593750764785 Probable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase) I.A.2 - Amino acids and amines Rv1002c - 23.5 6.2 8.4 23.9 18.2 21.4 38.9635595809427 0.575927590755818 0.400961616449895 1.43636589420969 0.150898252693911 0.69796750326314 hypothetical protein II.C.5 - Other membrane proteins Rv1003 - 12.5 4.6 12.6 16.7 18.2 10.6 16.7373544316025 0.416821189572069 0.56392743230413 0.739139764612967 0.459822132833376 NA hypothetical protein V - Conserved hypotheticals Rv1004c - 32.5 11.9 10 40.1 12.1 10.2 35.9496699021555 0.118286217985198 0.48031984999975 0.246265520746768 0.805476698607235 0.965592404376002 Probable membrane protein II.C.5 - Other membrane proteins Rv1005c pabB 35.1 20.8 19.1 30.6 26.5 16.9 53.6949423420008 -0.17521142522411 0.326320748690071 -0.536930078542201 0.591315913278028 0.928941202821899 Probable para-aminobenzoate synthase component I PABD I.G.2 - Folic acid Rv1006 - 262.8 167.2 123.7 199 213.9 143.1 500.99368813422 -0.162586242885365 0.183032323420867 -0.888292514931978 0.374383424935765 0.887356086865747 hypothetical protein VI - Unknowns Rv1007c metS 54.1 45.3 28.4 49.1 67.2 42.8 118.990044330557 0.132186701030036 0.268293984923913 0.492693494666021 0.622229174888842 0.931582271037618 Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1008 tatD 7.5 2.1 2.8 11.1 10.8 0 6.09004516868405 0.747590546783481 0.915643313483588 0.816464813071428 0.414234340456005 NA Probable deoxyribonuclease TatD (YJJV protein) V - Conserved hypotheticals Rv1009 rpfB 118.3 66.6 43.1 147.8 97.5 65.7 150.051244745255 0.321003596683437 0.26384485768391 1.21663768436224 0.223742098150533 0.774556499980442 Probable resuscitation-promoting factor RpfB V - Conserved hypotheticals Rv1010 ksgA 72.6 45.9 30.6 99.4 69.1 52.3 91.0062902636773 0.428305803291898 0.28036996381229 1.52764510672995 0.126600676054138 0.671582561030228 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) II.A.2 - Ribosome modification and maturation Rv1011 ispE 45.9 28.9 11.8 29.4 34.3 35.7 43.9273277575457 0.0693315916314886 0.383497927643186 0.180787395795254 0.856534456787328 0.975712312098852 Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) V - Conserved hypotheticals Rv1012 - 5.9 0 1.6 5.9 11.7 3 1.51089800861472 1.32619453957033 1.82060444273984 0.728436396417079 0.466346490113325 NA Hypothetical protein VI - Unknowns Rv1013 pks16 170.5 88.1 90.6 132.4 95.7 86.8 289.239664787721 -0.320880911962564 0.211141069256245 -1.51974655188061 0.128574686840225 0.671582561030228 Putative polyketide synthase Pks16 I.I - Polyketide and non-ribosomal peptide synthesis Rv1014c pth 13.3 4.2 3.8 12 27.6 9.9 9.6838747708259 1.02565694342984 0.730924156386368 1.40323306387985 0.160547351003669 NA Probable peptidyl-tRNA hydrolase Pth II.B.1 - RNA Rv1015c rplY 63.4 43.8 26.4 45.3 56 53.8 49.0792257518803 0.0254475393567143 0.346627333274292 0.0734146932855328 0.94147612559578 0.998153412295216 50S ribosomal protein L25 RplY II.A.1 - Ribosomal protein synthesis and modification Rv1016c lpqT 94.3 66.4 42.3 100.4 100.1 86 87.2092833349859 0.33889624162062 0.27219091488773 1.24506816019339 0.213106696712713 0.773070552038584 Probable conserved lipoprotein LpqT II.C.1 - Lipoproteins(lppA-lpr0) Rv1017c prsA 132.1 93.9 57.9 99.5 104.7 120.5 159.495754117602 0.0271734095208374 0.251476030852179 0.108055664107449 0.913951537077273 0.9932884147079 Probable ribose-phosphate pyrophosphokinase PrsA (phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv1018c glmU 81.6 46.7 40.9 57.7 81.1 71 150.138068260418 0.128644869875443 0.255955049324972 0.502607275045824 0.61524041337764 0.931582271037618 Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU II.C.3 - Murein sacculus and peptidoglycan Rv1019 - 178.3 126.9 83.2 159.4 106.9 90.7 116.768893698702 -0.265665219216655 0.261865430414121 -1.01451046362449 0.310339239083772 0.844880251285152 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv1020 mfd 62.4 42.4 23.1 74.3 52.6 27.1 268.758578160242 0.114121915574521 0.260495727628301 0.438095152705767 0.661317308103507 0.939577115195416 Probable transcription-repair coupling factor Mfd (TRCF) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1021 - 89.9 81.9 34.6 86.2 69.9 118.1 126.077052080582 0.273668115091413 0.314017419269698 0.871506159524129 0.383477844156638 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv1022 lpqU 77.8 52.1 28.3 58.8 43 53.3 60.2486303696982 -0.162324396756182 0.322677599308425 -0.503054432982276 0.614926002372093 0.931582271037618 Probable conserved lipoprotein LpqU II.C.1 - Lipoproteins(lppA-lpr0) Rv1023 eno 76.7 49.5 35.7 84.4 65.5 63.8 127.318670433566 0.248104329507671 0.242052923517 1.02500034249843 0.305363026059936 0.844880251285152 Probable enolase Eno I.B.1 - Glycolysis Rv1024 - 67.8 48 28.7 69.1 76 59.2 62.0876938435493 0.341492564226323 0.308235143275203 1.10789626581102 0.267906618485872 0.810756507522119 Possible conserved membrane protein VI - Unknowns Rv1025 - 72.9 40.6 31.8 94.1 64.2 80.3 46.8603434711002 0.561560181961783 0.346579306372467 1.62029345560025 0.105169254062579 0.63793455424801 hypothetical protein VI - Unknowns Rv1026 - 36.4 19.4 13.6 66.8 28.7 21.7 44.9098111846263 0.633305090446785 0.403733688574526 1.56862087155227 0.116736306195218 0.654954610417797 hypothetical protein III.E - Adaptations and atypical conditions Rv1027c kdpE 17.5 5.1 9.9 10.6 18.4 12.5 12.9793381493465 0.107078603108731 0.619113965039772 0.172954591812271 0.86268712011999 NA Probable transcriptional regulatory protein KdpE I.J.2 - Two component systems Rv1028c kdpD 19 10 10.3 13.1 12.8 10.9 52.0298396901696 -0.311074515869487 0.327513855249333 -0.949805667405031 0.342211005643192 0.855368447926409 Probable sensor protein KdpD I.J.2 - Two component systems Rv1028A kdpF 9.7 10.6 0 8.8 0 14.5 0.640714872913767 -0.700750673447572 2.52381499719039 -0.277655325064506 0.781276957970472 NA Probable membrane protein KdpF ? Rv1029 kdpA 5.1 3.8 1.9 6.2 5.4 0.7 9.53901882656258 0.0518541904721668 0.732579444775668 0.0707830267992923 0.943570440589542 NA Probable potassium-transporting ATPase a chain KdpA (potassium-translocating ATPase a chain) (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A) III.A.2 - Cations Rv1030 kdpB 8.4 7.3 2.7 7.4 9.3 7.9 23.4462637111232 0.203083354184394 0.469455302065613 0.432593589402064 0.665310047470299 NA Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B) III.A.2 - Cations Rv1031 kdpC 12.4 7.4 10 10.3 20.9 0 8.73481071563065 -0.148454363396903 0.766570894688217 -0.19366031821138 0.846441865021264 NA Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C) III.A.2 - Cations Rv1032c trcS 19.8 18.6 11.2 11.1 11.1 14.1 35.5270859475493 -0.69421226002881 0.405300036636132 -1.71283542382715 0.0867428211428455 0.569906516107151 Two component sensor histidine kinase TrcS I.J.2 - Two component systems Rv1033c trcR 31.9 47.2 13.6 31.7 14.3 8.2 30.343904954631 -0.89941973204255 0.517114804775027 -1.73930377497865 0.0819813436696598 0.562041621739757 Two component transcriptional regulator TrcR I.J.2 - Two component systems Rv1034c - 0.8 0 0 2.8 0 0.2 0.26794870561932 1.18528274565784 3.7576637810845 0.315430760895738 0.75243461420696 NA Probable transposase (fragment) IV.B.1.c - Others Rv1035c - 6 3 1.5 5.9 7.7 1.9 3.70077532505731 0.256825876606154 1.10394716524454 0.23264326834814 0.816038425713853 NA Probable transposase (fragment) IV.B.1.c - Others Rv1036c - 5.4 2.7 2.2 11.8 2.7 0 1.48943482972561 0.704738829030704 1.82488196653411 0.386183239220217 0.699360965925046 NA Probable IS1560 transposase (fragment) IV.B.1.c - Others Rv1037c esxI 20.3 11.4 10 11.2 11.7 17.9 6.15898750309715 -0.259329350372502 0.852297040362206 -0.304271091053295 0.76092136766164 NA Putative ESAT-6 like protein EsxI (ESAT-6 like protein 1) V - Conserved hypotheticals Rv1038c esxJ 8 12.1 12.2 14.2 10 0.5 4.18554566834379 -0.536308934258732 1.07530124774786 -0.49875226629002 0.617953918888128 NA ESAT-6 like protein EsxJ (ESAT-6 like protein 2) V - Conserved hypotheticals Rv1039c PPE15 1.4 0 0.4 0.1 0 0 0.313605488533802 -1.65929275229184 3.85084486801218 -0.430890573150607 0.666547938168238 NA PPE family protein PPE15 IV.C.2 - PPE family Rv1040c PE8 1.3 0 0 2.3 2.2 0 0.8411763727386 1.15819189039707 2.27199133935742 0.509769500584733 0.610212955431966 NA PE family protein PE8 IV.C.1.a - PE subfamily Rv1041c - 137.1 80.9 53 134.3 100.3 89.9 133.694816891858 0.123216376678236 0.245194428558742 0.50252518950983 0.615298138014461 0.931582271037618 Probable is like-2 transposase IV.B.1.c - Others Rv1042c - 280.9 164.3 99.4 285.1 198.4 194.4 129.10546827806 0.190663706870987 0.255151705782633 0.747256250104853 0.454908895698702 0.901158530199572 Probable is like-2 transposase IV.B.1.c - Others Rv1043c - 59.9 32.2 44.8 50.5 55.4 47.4 80.3356608190908 -0.0658968349334688 0.304592337869674 -0.216344361760223 0.828719332060312 0.968638603196576 hypothetical protein VI - Unknowns Rv1044 - 49.7 27.1 15 43.8 43.1 31.1 33.1504889463416 0.230679209607815 0.399734872301954 0.577080524096889 0.563885060241558 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv1045 - 52.1 34.3 21.5 61.6 50.3 53.8 62.734252646219 0.461433959024497 0.307068133888248 1.50270870891614 0.132914175958295 0.680441181456551 Hypothetical protein VI - Unknowns Rv1046c - 338.6 216.2 248.1 157.9 355.5 280.2 231.079416637036 -0.236356504166269 0.305147645226692 -0.774564404685744 0.438597097492342 0.901158530199572 Hypothetical protein VI - Unknowns Rv1047 - 3.8 4.1 0 2.7 1.5 2.3 4.11155489739138 -0.650764238644582 1.12857821253057 -0.576623074430436 0.564194108209949 NA Probable transposase IV.B.1.b - IS1081 Rv1048c - 10.6 7.7 5.5 7.9 8.9 9.3 14.7143471901123 -0.0502537403312855 0.562180470285589 -0.0893907614858206 0.928771365345386 NA Hypothetical protein VI - Unknowns Rv1049 - 15.2 0 19.2 17.1 16.5 6.3 8.53518467055046 -0.195154081361467 0.842385426643899 -0.231668396898756 0.816795579254065 NA Probable transcriptional repressor protein I.J.1 - Repressors/activators Rv1050 - 1.6 1.9 1.2 2.7 6.1 0 2.7461658998141 1.1629276933026 1.28758531466906 0.903184961845808 0.366427737743741 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1051c - 1.2 0 0 0 0 0 0.156802744266901 -1.09373598727695 4.02036243158163 -0.272049101515128 0.785584265026673 NA hypothetical protein V - Conserved hypotheticals Rv1052 - 78.1 55.8 37.1 65.6 87.8 65.7 40.0586381315439 0.165717295747721 0.368846292589079 0.449285512901553 0.653225707088244 0.939577115195416 Hypothetical protein VI - Unknowns Rv1053c - 0 0 0 0.6 0 10.3 0.505918538770106 1.75670377844812 3.22897648087044 0.544043534802879 0.586411515054753 NA Hypothetical protein VI - Unknowns Rv1054 - 68.5 24.3 29 42 58.3 25.4 19.4161747225543 -0.180400868401521 0.51155474159127 -0.352652128373117 0.724349252329046 NA Probable integrase (fragment) IV.B.3 - Phage-related functions Rv1055 - 71.4 82 38.3 41.3 81.6 126.1 15.9780439235796 0.116311109596742 0.617699783936829 0.188297151175039 0.850643718446256 NA Possible integrase (fragment) IV.B.3 - Phage-related functions Rv1056 - 19.5 5.7 12.2 21.8 9.6 16.6 16.7484792931817 0.147867753699524 0.562792813964451 0.262739235524183 0.792751573311555 NA hypothetical protein V - Conserved hypotheticals Rv1057 - 61.2 43.2 45.5 82.1 112 45 121.438638453851 0.446775797198183 0.292980251577526 1.52493485411579 0.127275347366209 0.671582561030228 hypothetical protein V - Conserved hypotheticals Rv1058 fadD14 26.2 8.6 19.3 29.9 20.4 19.2 53.4894696030159 0.142597924633892 0.372042747261408 0.383283710497113 0.701509415899621 0.947279830180307 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1059 - 54.3 32.2 18.8 45.5 33.6 30.7 59.3986423606112 -0.0705158929175618 0.319612493100993 -0.220629338463562 0.825381055138363 0.967727711626973 hypothetical protein V - Conserved hypotheticals Rv1060 - 54.3 22.2 16.9 70.5 39.3 41.2 28.7851256955849 0.554736870245758 0.44168916271256 1.25594403729296 0.209136260758093 0.770341510876847 hypothetical protein VI - Unknowns Rv1061 - 31.8 30.9 22.7 21 39.1 20.2 38.6631200071959 -0.319944832205255 0.407927690431727 -0.784317514377715 0.432853825025616 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1062 - 15.8 15.1 9.7 22 8.5 10.9 18.0736336092525 -0.0873364606769261 0.543504506264612 -0.160691327615976 0.872336520227461 NA hypothetical protein V - Conserved hypotheticals Rv1063c - 85.7 43.4 38.5 62.9 61.1 64.2 101.174211856318 -0.0102125252599329 0.265443940459999 -0.0384733787564906 0.969310256439185 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv1064c lpqV 16.2 13.9 6.8 9.2 5.8 23 7.92382744342187 -0.264073204730123 0.795122417664147 -0.332116412345533 0.739801357590923 NA Possible lipoprotein LpqV II.C.1 - Lipoproteins(lppA-lpr0) Rv1065 - 194.2 85.5 82.1 153.3 140.9 159.2 121.200460222068 0.175801127775874 0.26283325755656 0.668869417098187 0.503578780592149 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv1066 - 74.3 23.1 26.5 91.3 32.5 23.6 26.0962452798702 0.158726658860999 0.516708826491864 0.307187821695743 0.758700414575614 NA hypothetical protein V - Conserved hypotheticals Rv1067c PE_PGRS19 1.8 1.7 1.2 5.1 1.8 3.2 7.03457824219271 1.01775395561991 0.81194196454135 1.25348116006644 0.210030651266064 NA PE-PGRS family protein PE_PGRS19 IV.C.1.b - PE_PGRS subfamily Rv1068c PE_PGRS20 5.7 4.8 2.7 10.4 6.1 8.1 12.9458763267124 0.792033198412402 0.600760756668456 1.31838371534894 0.187375229372817 NA PE-PGRS family protein PE_PGRS20 IV.C.1.b - PE_PGRS subfamily Rv1069c - 59.6 30.6 30.2 58.8 58.8 57.2 137.283975065064 0.36040271745633 0.24236545086224 1.48702183489503 0.137009044147175 0.682181933169668 hypothetical protein V - Conserved hypotheticals Rv1070c echA8 77 68.5 43.1 92.8 87.3 101.2 97.6871343941371 0.405451570155083 0.284373398637091 1.42577179194074 0.153934225759406 0.703772013967798 Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1071c echA9 48 33.1 11.8 37.3 36.1 58.9 61.4117459881643 0.390664752533944 0.37671998338226 1.03701627141328 0.299728274032034 0.84163380028938 Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1072 - 1091.7 533.8 472.9 843.8 756.1 513.9 922.102393947137 -0.137722313299808 0.180816479642512 -0.761669033553222 0.446257561669952 0.901158530199572 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1073 - 278.3 113 108.4 122.7 162.9 133.8 205.554524865223 -0.38378745095711 0.247736570989411 -1.54917559980885 0.121339513343493 0.665646250765128 hypothetical protein V - Conserved hypotheticals Rv1074c fadA3 364 247.4 205.9 279.4 288.8 241.4 534.185163376573 -0.201540533366741 0.182995932637509 -1.10133886836691 0.270749200645515 0.812783093966197 Probable beta-ketoacyl CoA thiolase FadA3 I.A.3 - Fatty acids Rv1075c - 19.3 10.4 10 16.1 21.5 18 23.453983408039 0.291672863284864 0.46013239973091 0.633888992506151 0.526153269713418 NA Conserved exported protein V - Conserved hypotheticals Rv1076 lipU 58.6 27 33.8 32.6 24.8 15.3 45.8157016251713 -0.854938896535274 0.364425762065778 -2.34598918498237 0.0189766580954785 0.288108079878605 Possible lipase LipU II.B.5 - Esterases and lipases Rv1077 cbs 182.6 77.6 74 156 121.7 75.1 246.874090546901 -0.0577487084596626 0.237392721121762 -0.243262338401869 0.807802177775152 0.965592404376002 Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) I.D.3 - Serine family Rv1078 pra 155.5 89.2 76.2 203.7 109.4 77.6 133.553312199866 0.129877654972904 0.283570992410817 0.458007548193597 0.646947018354442 0.939577115195416 Probable proline-rich antigen homolog Pra V - Conserved hypotheticals Rv1079 metB 75.6 47.3 38.5 93 71.7 61.7 118.558248119601 0.326768633613216 0.24708576756384 1.32249071581506 0.186004798908178 0.739746500217031 Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase) I.D.2 - Aspartate family Rv1080c greA 1006.5 590 486.3 542.5 886.5 658.9 552.334941896815 -0.152050029387392 0.224050320885284 -0.678642319219187 0.497364521808144 0.914093200877957 Probable transcription elongation factor GreA (transcript cleavage factor GreA) II.A.6 - Protein translation and modification Rv1081c - 21.1 6.7 6.3 18 33.4 6.8 9.20196872452031 0.615980444179793 0.755256646342977 0.815590895045317 0.414734158683366 NA Probable conserved membrane protein VI - Unknowns Rv1082 mca 102.6 77.3 63.9 106.9 74.9 45.8 109.154849014505 -0.278741836762832 0.282231641046545 -0.987634964418684 0.32333145605183 0.852559396987 Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) IV.D - Antibiotic production and resistance Rv1083 - 116.6 64.9 50.8 104.8 158.6 65.3 38.3888319070397 0.338534551665495 0.386376735885006 0.876177368417572 0.380933617795207 0.893490749801147 hypothetical protein V - Conserved hypotheticals Rv1084 - 35.3 10.5 13.3 35.4 25.3 15.2 68.7414535146548 0.24779206225364 0.342631267930153 0.723203295923809 0.469554994206195 0.902597484602108 hypothetical protein V - Conserved hypotheticals Rv1085c - 41.6 38.6 26.5 37 49.1 48.8 47.4962594686214 0.102770572421927 0.36594467893941 0.28083636226049 0.778835912439373 0.963013023606306 Possible hemolysin-like protein IV.A - Virulence Rv1086 - 178.8 84 64.3 171 121.4 102.3 146.34343953487 0.147261640878885 0.251315748802517 0.585962644922038 0.557900617919932 0.92521033104044 Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase) V - Conserved hypotheticals Rv1087 PE_PGRS21 25.2 10.2 10.6 37.3 21 11.7 66.9085089448597 0.459544373319949 0.356210597149754 1.29009180804004 0.19701878382296 0.751109817915875 PE-PGRS family protein PE_PGRS21 IV.C.1.b - PE_PGRS subfamily Rv1087A - 0.2 0 0 0.1 0 0 0 NA NA NA NA NA hypothetical protein ? Rv1088 PE9 4 4.5 0.8 0 4.2 0 0.93881237001376 -1.33984390556388 2.22347450937616 -0.602590180329883 0.54678135447896 NA PE family protein PE9 IV.C.1.a - PE subfamily Rv1089 PE10 3.7 13.4 0 1.5 5 0 1.92903398523007 -1.90377377424597 1.70847153990451 -1.11431401096232 0.265144498297339 NA PE family protein PE10 IV.C.1.a - PE subfamily Rv1089A celA2a 2.2 2 9.5 0 0 0 0.305638047057687 -1.35633987645814 3.57672601242054 -0.379212685497328 0.704529932188578 NA Probable cellulase CelA2a (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) ? Rv1090 celA2b 28.3 16.2 7.8 18.9 10.7 12.3 10.6070183529685 -0.45933772865725 0.666920066264181 -0.688744801502639 0.490983877348893 NA Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1091 PE_PGRS22 20.2 9.4 11 28.7 10.4 5.5 56.1751367511597 -0.0215002418229794 0.420065673080704 -0.0511830487487815 0.959179659277743 0.998153412295216 PE-PGRS family protein PE_PGRS22 IV.C.1.b - PE_PGRS subfamily Rv1092c coaA 111.5 123.2 70.2 71.9 109.4 71.3 143.69104453272 -0.49512652068961 0.288756732454859 -1.71468390184465 0.0864031966011275 0.569906516107151 Probable pantothenate kinase CoaA (pantothenic acid kinase) I.G.5 - Pantothenate Rv1093 glyA1 181.8 160.1 104.6 170.6 183.9 152.3 329.448357310789 -0.0168890426208822 0.214060392766397 -0.078898494030669 0.93711336109856 0.998153412295216 Serine hydroxymethyltransferase 1 GlyA1 I.D.3 - Serine family Rv1094 desA2 4689.7 2876.8 2226.9 3510.3 3397 2658.8 4262.72111278695 -0.19783935821557 0.150588564082383 -1.31377411970897 0.188922229380248 0.739746500217031 Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) I.H.2 - Modification of fatty and mycolic acids Rv1095 phoH2 701.7 420 417.8 573.3 531.6 373.5 1054.73104019992 -0.260535401128691 0.178609619325122 -1.4586862796815 0.144651474105082 0.690135194188255 Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH) I.A.4 - Phosphorous compounds Rv1096 - 110.6 81.1 75.7 72.2 88.2 113.7 130.506646837529 -0.190004410012794 0.292914858811651 -0.648667707686931 0.516553181278749 0.915911629458156 Possible glycosyl hydrolase I.A.1 - Carbon compounds Rv1097c - 153.8 125.9 73.3 123.2 124.2 109.7 167.812827439164 -0.153913596704718 0.236892771729718 -0.649718417243751 0.515874125150066 0.915911629458156 Probable membrane glycine and proline rich protein II.C.5 - Other membrane proteins Rv1098c fum 96.8 106 52.6 100.7 96.5 75.9 203.30979771878 -0.0997096029878904 0.255093932097731 -0.390874068104802 0.695890322808856 0.944008157375819 Probable fumarase Fum (fumarate hydratase) I.B.3 - TCA cycle Rv1099c glpX 122.2 80.9 66.1 90.7 75.6 84 152.137013285242 -0.291478275305214 0.235360799251117 -1.23843170244431 0.215556031679365 0.773070552038584 Fructose 1,6-bisphosphatase GlpX V - Conserved hypotheticals Rv1100 - 164.8 117.3 82.7 128.7 132 152.9 146.874646630421 0.00335810429854302 0.251732345375028 0.0133399793877904 0.989356552081874 0.999120249206713 hypothetical protein V - Conserved hypotheticals Rv1101c - 125.4 81.6 42.1 99.9 112.8 55.1 154.340377103989 -0.0304173054874576 0.262961694954501 -0.115672001173861 0.907912497093491 0.992210970746976 hypothetical protein II.C.5 - Other membrane proteins Rv1102c mazF3 448.9 315.5 264.2 184 390.4 320.2 163.888989239818 -0.415634749285575 0.300732055763274 -1.38207664038565 0.166948170125856 0.725041090026968 Toxin MazF3 V - Conserved hypotheticals Rv1103c mazE3 453.2 267.1 240.9 440.9 361 361.9 181.112278411952 0.101774826430671 0.221453244973933 0.459577038226065 0.645819843775811 0.939577115195416 Possible antitoxin MazE3 VI - Unknowns Rv1104 - 33.8 12.8 11.5 49.1 24.1 31 28.031447945523 0.719650939785961 0.451083463905946 1.59538311059882 0.110626590487086 0.646919977351541 Possible para-nitrobenzyl esterase (fragment) II.B.5 - Esterases and lipases Rv1105 - 5.3 5.9 5.6 3.5 7.2 0 3.40374389208178 -0.73571599892123 1.15875091527666 -0.634921611902737 0.525479540995941 NA Possible para-nitrobenzyl esterase (fragment) II.B.5 - Esterases and lipases Rv1106c - 134.7 88.5 65.2 119.9 92.8 101.8 178.440445466164 -0.0409196909091999 0.225105476823533 -0.181780076995986 0.85575532027031 0.975712312098852 3-beta-hydroxysteroid dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1107c xseB 509.4 342.3 230.1 605.7 428.4 439.8 173.004128658647 0.288971778969998 0.230220261849977 1.25519698678089 0.209407259128651 0.770341510876847 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) II.B.2 - DNA Rv1108c xseA 192.5 116.2 97.3 183 151.6 122.8 285.09684970014 0.00318015437673174 0.197210357983296 0.0161256964859884 0.987134113347479 0.999120249206713 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) II.B.2 - DNA Rv1109c - 842.7 639.7 496.5 782.9 1020.3 915.3 809.660102062398 0.272313639482152 0.208260177474592 1.30756461837441 0.191021024222801 0.741700010610815 hypothetical protein VI - Unknowns Rv1110 lytB2 402.4 239.2 188.8 413.9 339.4 217.4 475.371251990439 0.0566634714092517 0.196075443882657 0.288988107267335 0.772590478493022 0.962433896292784 Probable LYTB-related protein LytB2 II.C.3 - Murein sacculus and peptidoglycan Rv1111c - 71 35.7 45.2 71.6 81.1 42.1 89.8597144071301 0.164639280530477 0.291970503068953 0.563890114925736 0.57282891784106 0.925885039001838 hypothetical protein VI - Unknowns Rv1112 - 11.3 8.5 5.7 8.7 7.3 10.1 14.394994363608 -0.132724423740007 0.566482590017591 -0.234295680183014 0.814755439319746 NA Probable GTP binding protein V - Conserved hypotheticals Rv1113 vapB32 39.9 16.8 6.1 58.2 62.1 55.9 11.2982815345977 1.38210867302735 0.683601536892529 2.02180451394251 0.043196551269325 NA Possible antitoxin VapB32 VI - Unknowns Rv1114 vapC32 24.7 19.4 12.2 28.9 35.6 16.3 13.0738359519011 0.333960317091401 0.593289895719104 0.562895676297708 0.573505924579891 NA Possible toxin VapC32 Contains PIN domain V - Conserved hypotheticals Rv1115 - 18.1 23 13.8 19.7 10.1 16.4 19.0949621278392 -0.468096689075028 0.535867195585437 -0.873531152739497 0.382373633707357 NA Possible exported protein VI - Unknowns Rv1116 - 12.4 7 2.1 7.6 27.6 15.8 2.65724235650294 0.97937766394123 1.32705315879623 0.738009368689965 0.460508756021319 NA Hypothetical protein VI - Unknowns Rv1116A - 38.4 9.4 13.3 37.3 31.8 11.7 8.72071396513209 0.224451188155086 0.755564928116139 0.297064063990785 0.766417599370992 NA Conserved hypothetical protein (fragment) ? Rv1117 - 924.2 824.3 480 621.1 940 782.8 401.613574963694 -0.108851204987076 0.243499476000282 -0.447028497863994 0.654854483861827 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv1118c - 6.5 8.3 3.6 6.4 6.4 3.3 7.16378795158297 -0.266705264844164 0.797027132756338 -0.334625075964257 0.737907926498069 NA hypothetical protein VI - Unknowns Rv1119c - 3.1 0.9 1.1 1 2.1 0 0.0896015681525148 -0.706868028450054 4.02314057484366 -0.17570055415663 0.860529199923768 NA Hypothetical protein VI - Unknowns Rv1120c - 7 6.7 8.5 8.9 16.3 17.2 8.61266039518975 0.717046106452746 0.766069871938065 0.936006143458827 0.349270024634913 NA hypothetical protein V - Conserved hypotheticals Rv1121 zwf1 140.5 97.4 63.1 133 120.7 95.7 239.952587713682 0.0555117012698046 0.206719458179631 0.268536410450376 0.788286452209138 0.963989543249515 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) I.B.5 - Pentose phosphate pathway Rv1122 gnd2 163.9 98.6 86.4 171 137.4 122.4 210.775759517712 0.128164509290602 0.211689161110778 0.605437277081619 0.544888488763925 0.92521033104044 Probable 6-phosphogluconate dehydrogenase,decarboxylating Gnd2 I.B.5 - Pentose phosphate pathway Rv1123c bpoB 51.8 33.2 28.4 49.5 54.3 26.8 58.2384500882774 0.0247477811090988 0.320346287254823 0.0772532165775122 0.938422107390862 0.998153412295216 Possible peroxidase BpoB (non-haem peroxidase) III.F - Detoxification Rv1124 ephC 16.7 10 13.6 24.8 13.6 6 21.0675001423436 -0.0436080595847847 0.527097443589727 -0.0827324437162849 0.934064286939248 NA Probable epoxide hydrolase EphC (epoxide hydratase) III.F - Detoxification Rv1125 - 9.2 2.8 5.1 13.9 12.2 5.3 14.4582433802647 0.685467530454108 0.589595040510649 1.16260735480479 0.244988845380189 NA hypothetical protein VI - Unknowns Rv1126c - 75.5 45.3 54.4 47.4 69.3 58.2 57.3729594804508 -0.270568442794371 0.345393576572055 -0.78336269446495 0.43341415661239 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1127c ppdK 94.1 61.2 45.1 63.3 60.2 64.6 153.655036272965 -0.263492118695451 0.236576060581093 -1.11377338031686 0.265376419644308 0.80816433845196 Probable pyruvate, phosphate dikinase PpdK I.C.1 - General Rv1128c - 23.4 20.8 11.6 17.6 20 27.3 43.8208555942276 -0.0015172213188204 0.383167249462608 -0.00395968423958025 0.99684063733558 0.999833281786427 hypothetical protein IV.B.2 - REP13E12 family Rv1129c - 5.6 6 5.1 7.9 6.3 9.1 15.3301287998782 0.256469810286677 0.570774667787967 0.449336357691949 0.653189033891444 NA Probable transcriptional regulator protein I.J.1 - Repressors/activators Rv1130 prpD 10.7 18.6 2.7 9.7 14 9 27.0865359431346 -0.0969565526626373 0.536062256540064 -0.180868082913409 0.85647112177791 0.975712312098852 Possible methylcitrate dehydratase PrpD V - Conserved hypotheticals Rv1131 prpC 11.4 16.1 5.4 9.6 15.6 7.2 20.6030184959195 -0.194630739642175 0.527852771909286 -0.368721639820474 0.712335217311198 NA Probable methylcitrate synthase PrpC I.B.3 - TCA cycle Rv1132 - 24.7 17.9 15.5 29.3 25.5 27.8 65.0890685563877 0.310780594701812 0.308122952794087 1.00862526430967 0.313154386188411 0.846061021823653 hypothetical protein II.C.5 - Other membrane proteins Rv1133c metE 659.1 314.8 341 567.9 403.8 367.6 1602.52815628984 -0.141927801366601 0.188498315028895 -0.752939363648132 0.451486352361888 0.901158530199572 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) I.D.2 - Aspartate family Rv1134 - 9.2 6.8 5.5 6.3 7.8 1.1 1.84761902618655 -0.904035156554173 1.51415949118268 -0.597054116041667 0.550471250784137 NA Hypothetical protein VI - Unknowns Rv1135c PPE16 8.8 7.4 5.8 6.6 6.1 9.1 22.1023173685696 -0.225676962545666 0.487855583320838 -0.462589688959754 0.643658500859252 NA PPE family protein PPE16 IV.C.2 - PPE family Rv1135A - 4.1 0 0 2.2 0 2 0.253585776819384 -0.418882921657029 3.83865594459157 -0.109122288557069 0.913105496739987 NA Possible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase) ? Rv1136 - 11.8 0 6.3 12.4 10.8 5.2 3.76801466069216 0.391639756357057 1.09147100588391 0.358818286739459 0.719731031598768 NA Possible enoyl-CoA hydratase I.A.3 - Fatty acids Rv1137c - 10.3 0 0 6.1 0 12.3 2.19734585788458 0.434806252171141 1.60232000380527 0.271360434331808 0.786113829542124 NA Hypothetical protein VI - Unknowns Rv1138c - 11.6 6.5 3.8 14.1 6.9 8.4 13.2171491304346 0.322611146260523 0.598003937266906 0.539479970207173 0.58955571404236 NA Possible oxidoreductase V - Conserved hypotheticals Rv1139c - 27.6 10.5 14.1 26.6 12.2 20.6 14.5821062377751 -0.00512546556159257 0.579965770266949 -0.00883753115159434 0.992948762124561 NA hypothetical protein V - Conserved hypotheticals Rv1140 - 75.6 33 29.9 77.2 50.7 76 75.7927883351713 0.408572672913953 0.313101650724897 1.304920213509 0.191920017488792 0.741700010610815 Probable integral membrane protein V - Conserved hypotheticals Rv1141c echA11 48.1 15.4 12 25.2 27.4 10.4 27.4198616879563 -0.383976753428396 0.473259685324715 -0.811344733842987 0.417167727378693 0.901158530199572 Probable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1142c echA10 189.7 117.6 78.8 159.8 134.1 85.1 161.025129603604 -0.167431238508131 0.237592384113766 -0.704699517758785 0.480997251514979 0.907292899730371 Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1143 mcr 45 28.7 23.6 31.2 25.8 23.8 51.5401411201183 -0.439570464805705 0.327755041321252 -1.341155464867 0.179869982368147 0.735038480974451 Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) I.A.3 - Fatty acids Rv1144 - 27.5 17 8.1 19 8.4 15 17.9736310889701 -0.45540439583681 0.54136703279645 -0.841211910308617 0.400229229329809 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1145 mmpL13a 7.5 0.3 2.4 6.8 10.1 3.1 6.09021812181173 0.735489200342347 0.926910048081538 0.793484979329567 0.427495317261044 NA Probable conserved transmembrane transport protein MmpL13a III.A.6 - Efflux proteins Rv1146 mmpL13b 8.7 6.1 2.5 8.8 8.5 2 12.3168756999701 0.0241105459565468 0.643076403876167 0.0374925060400593 0.970092315261228 NA Probable conserved transmembrane transport protein MmpL13b III.A.6 - Efflux proteins Rv1147 - 12.5 16.2 3.3 9.3 5.8 13 10.3958672484129 -0.337199971406483 0.72048411651788 -0.468018605373537 0.639771284669206 NA hypothetical protein IV.H - Miscellaneous transferases Rv1148c - 29.5 28.9 25.4 27.8 36.3 21.5 67.293380098663 -0.210196115853937 0.335560843263638 -0.626402394896813 0.53105103911953 0.922751607774049 hypothetical protein IV.B.2 - REP13E12 family Rv1149 - 309.1 144.2 157.9 311.3 247.2 158.9 141.466081170365 0.0714799862340069 0.253494953476243 0.281977945729424 0.777960421161135 0.963013023606306 Possible transposase IV.B.1.c - Others Rv1151c - 28.7 19.8 18.9 29.4 34.6 18.1 27.6769723053674 0.113268055253617 0.427563378652333 0.264915240427358 0.79107475750732 0.964516371138273 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv1152 - 124.7 63.8 85.4 131 118 62.9 56.5355425710849 -0.000400931179386105 0.339539896358922 -0.00118080727385947 0.999057852325844 0.999833281786427 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1153c omt 24 15.1 10.9 12.1 22 25.4 24.2234091937573 -0.0282811759948329 0.488301820571111 -0.0579174084621589 0.953814416450584 NA Probable O-methyltransferase Omt I.I - Polyketide and non-ribosomal peptide synthesis Rv1154c - 46.2 43.6 21.7 47.8 41.9 42.1 41.1616609667778 0.0711510212391334 0.370797559960084 0.191886433251591 0.847831164666455 0.975474031954732 Hypothetical protein VI - Unknowns Rv1155 - 358.6 233.3 157.1 324.4 369 283.5 201.768475872516 0.221985219484 0.218566486656137 1.01564161496196 0.309800080232695 0.844880251285152 Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) VI - Unknowns Rv1156 - 689.6 352.5 341.4 487.2 493.2 409.3 432.981880675073 -0.158920717705295 0.188451664812423 -0.843296968819449 0.399062377659464 0.893826103932853 hypothetical protein VI - Unknowns Rv1157c - 55.7 30.5 24.6 53.9 47.1 34.1 70.9719452133817 0.143811601180513 0.291358785086959 0.49358937688318 0.621596204694633 0.931582271037618 Conserved ala-, pro-rich protein V - Conserved hypotheticals Rv1158c - 81 29.9 43.2 54.4 79.8 61.8 62.5130794107756 0.14444443629151 0.33875074432616 0.426403303050557 0.669813994966174 0.940710721884994 Conserved hypothetical ala-, pro-rich protein V - Conserved hypotheticals Rv1159 pimE 32.7 17.4 18.6 28.1 16.4 35.2 51.3019302111008 0.0119643695035828 0.366578277928295 0.0326379663606885 0.973963293170102 0.998153412295216 Mannosyltransferase PimE II.C.5 - Other membrane proteins Rv1159A - 228 135.4 86.5 94.3 192.3 142.2 65.6929313309677 -0.2646181629301 0.350393335537618 -0.755203184798277 0.450127078038127 0.901158530199572 hypothetical protein ? Rv1160 mutT2 56.1 39.2 12.9 46.5 21.7 37.4 23.19144898354 -0.139971181420839 0.49965687030995 -0.280134607844002 0.779374234003015 NA Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1161 narG 608.3 365.7 354.4 380.4 378.6 298.2 2390.56139874363 -0.521205184363214 0.165757020828409 -3.14439280917557 0.00166431871343949 0.0676986111966712 Respiratory nitrate reductase (alpha chain) NarG I.B.6.b - anaerobic Rv1162 narH 328.4 200.7 180.5 199.6 252.6 187.1 609.395617593078 -0.333850168439705 0.192277885201193 -1.73628999554669 0.0825125712937178 0.562041621739757 Probable respiratory nitrate reductase (beta chain) NarH I.B.6.b - anaerobic Rv1163 narJ 112.5 46.7 46.9 98.1 60.9 23.4 60.026246469933 -0.290955915957519 0.37242121145443 -0.781254952748901 0.434652558967227 0.901158530199572 Probable respiratory nitrate reductase (delta chain) NarJ I.B.6.b - anaerobic Rv1164 narI 74.6 49.4 24.6 74.2 60.1 40.7 61.3883081173625 0.115188564360769 0.323369050237888 0.356213942787754 0.7216803510577 0.949890877982223 Probable respiratory nitrate reductase (gamma chain) NarI I.B.6.b - anaerobic Rv1165 typA 81.9 60.3 44.5 81.7 59.4 61.2 196.540407920505 -0.0536450089991138 0.2243718510961 -0.239089746494703 0.81103599235722 0.966073477417693 Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein) V - Conserved hypotheticals Rv1166 lpqW 78.2 39 34.2 54.9 64.8 65.8 169.355705118286 0.134543542250515 0.245670150082596 0.547659299289232 0.583925863824759 0.928941202821899 Probable conserved lipoprotein LpqW II.C.1 - Lipoproteins(lppA-lpr0) Rv1167c - 113.9 92.2 49.5 126.9 116.2 84.2 92.7815830402519 0.21040986003239 0.275793047295226 0.76292662957219 0.445507153801106 0.901158530199572 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1168c PPE17 69.8 58.6 29.3 45.7 66.3 51.1 89.1275536182275 -0.126980152205849 0.302701085358148 -0.419490244164832 0.674857883104518 0.941804694584811 PPE family protein PPE17 IV.C.2 - PPE family Rv1169c lipX 25.4 38.8 5.6 16.9 46.5 38.1 13.0722826585372 0.346994663690041 0.694967449676903 0.49929628193574 0.617570674056517 NA PE family protein Possible lipase LipX IV.C.1.a - PE subfamily Rv1170 mshB 26.2 13.6 14.6 27.4 17 15.3 27.0034106674224 -0.0336437291687757 0.435402566614308 -0.0772703969808665 0.938408440265393 0.998153412295216 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) IV.D - Antibiotic production and resistance Rv1171 - 128 44.2 37.4 116.9 94.8 58.7 52.5960618231742 0.266993438316998 0.362301130621347 0.736937910900536 0.461160108124485 0.901158530199572 hypothetical protein VI - Unknowns Rv1172c PE12 101.2 40.7 64.9 71.8 72.8 55.5 100.76033543411 -0.257586300459284 0.289425863059562 -0.889990610155922 0.373470928017295 0.887356086865747 PE family protein PE12 IV.C.1.a - PE subfamily Rv1173 fbiC 267.3 159.2 126.8 218.9 179.3 141.2 743.753044006715 -0.201484060169697 0.172479484050829 -1.16816247032789 0.242741235604305 0.78958848015113 Probable F420 biosynthesis protein FbiC V - Conserved hypotheticals Rv1174c TB8.4 1312.4 745.8 707.6 532.8 1147 768.5 468.930202982355 -0.346184457377066 0.2637902578577 -1.31234739367749 0.189402947968496 0.739746500217031 Low molecular weight T-cell antigen TB8.4 VI - Unknowns Rv1175c fadH 65.2 26.9 25 55.9 52.1 39.2 137.545810356136 0.19244668077383 0.250387545387293 0.768595260903085 0.442133619726503 0.901158530199572 Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) I.A.3 - Fatty acids Rv1176c - 24.5 6.1 7.7 15 28.5 11.7 12.4054681720572 0.300265726946317 0.648910877868032 0.462722597489546 0.64356321852353 NA hypothetical protein V - Conserved hypotheticals Rv1177 fdxC 2971 1911.4 1493 1612.5 1940.3 1477.5 1004.79887552692 -0.512369977331111 0.177473513989025 -2.88702221427134 0.0038890677140218 0.116925666271568 Probable ferredoxin FdxC I.B.6.c - Electron transport Rv1178 - 922.9 467.6 414.2 715.6 549.8 423.4 1000.27239407895 -0.250193388037871 0.180744276579094 -1.3842396161761 0.166285096618574 0.725041090026968 Probable aminotransferase IV.H - Miscellaneous transferases Rv1179c - 34.7 24.6 18.4 40 35.9 32.3 138.480632484972 0.307965745042092 0.235041919668272 1.31025880607485 0.190108298012961 0.739746500217031 hypothetical protein VI - Unknowns Rv1180 pks3 94.7 59.6 33.3 95.8 81.4 83.8 171.371578085859 0.348390306537577 0.238359372835712 1.46161781847657 0.143845968791129 0.690135194188255 Probable polyketide beta-ketoacyl synthase Pks3 I.I - Polyketide and non-ribosomal peptide synthesis Rv1181 pks4 99.6 58.8 45.1 108.8 101.5 73.8 605.954171784806 0.322889217704882 0.174282488856056 1.85267733909609 0.0639286199208054 0.514454587842348 Probable polyketide beta-ketoacyl synthase Pks4 I.I - Polyketide and non-ribosomal peptide synthesis Rv1182 papA3 307.9 243.2 216 161.9 375.5 298.2 627.008662174291 -0.0780331401420214 0.286882617292554 -0.272003723608132 0.785619156232634 0.963989543249515 Probable conserved polyketide synthase associated protein PapA3 I.I - Polyketide and non-ribosomal peptide synthesis Rv1183 mmpL10 146.9 95.7 78.6 111.8 129.7 87.8 523.234792731358 -0.148889220411694 0.186475914585923 -0.798436735072775 0.424617092679939 0.901158530199572 Probable conserved transmembrane transport protein MmpL10 II.C.4 - Conserved membrane proteins Rv1184c - 757.3 592 445.4 328.7 713 593.3 1017.37035930323 -0.307019205700049 0.270962421244816 -1.13306931747061 0.257185145057608 0.801096972105118 Possible exported protein V - Conserved hypotheticals Rv1185c fadD21 714.5 636.2 384.1 486.6 763 686.4 1734.62570497869 -0.0143486361554992 0.237435573171767 -0.0604317034883352 0.951811809058733 0.998153412295216 Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1186c - 20.9 10.5 8.4 15.7 13.7 12.8 34.502943324516 -0.0713155664128908 0.384852633315852 -0.185306167190394 0.85298890108407 0.975712312098852 hypothetical protein VI - Unknowns Rv1187 rocA 36.3 28 17.1 33.6 23.2 23.8 70.0472376469286 -0.171699233094482 0.302242527248908 -0.568084295275499 0.569977731053113 0.92521033104044 Probable pyrroline-5-carboxylate dehydrogenase RocA I.A.2 - Amino acids and amines Rv1188 - 15.5 7 9.4 15.8 6.1 18 18.5353226095141 0.123630194146906 0.545007164427813 0.226841410932096 0.820547061665131 NA Probable proline dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1189 sigI 12.9 2 5.3 8.2 12.6 3.1 8.83313687420936 -0.00965815132392545 0.770641919986492 -0.0125326057062854 0.990000689159979 NA Possible alternative RNA polymerase sigma factor SigI II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1190 - 5.3 1.9 0.8 7.8 8.2 8.5 6.60928460843427 1.44597065443029 0.862605734495813 1.67628221863775 0.0936829261503637 NA hypothetical protein V - Conserved hypotheticals Rv1191 - 32.8 18.8 10.9 21.1 14.1 15.8 26.4272083486173 -0.428993088406619 0.442757065626491 -0.96891302637848 0.332588585520115 NA hypothetical protein V - Conserved hypotheticals Rv1192 - 216 98.3 112.1 236 195.4 108.1 207.747295515727 0.165374436922233 0.246675001348388 0.670414253646516 0.50259375079814 0.915911629458156 hypothetical protein VI - Unknowns Rv1193 fadD36 72.4 28.1 29.2 76.8 39.2 27.6 98.9613316621452 0.0280851190260777 0.321661385577465 0.0873126843486596 0.930422971874471 0.998010361628995 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1194c - 127.4 69.7 54 106 119.6 64.5 178.367571045967 0.0553344530974537 0.232620804752741 0.237874050673457 0.811978782452661 0.966073477417693 hypothetical protein V - Conserved hypotheticals Rv1195 PE13 1036.6 941.4 1068 805.3 1400.3 1390.9 561.253588236041 -0.0181039585307351 0.297776126263885 -0.0607972128520862 0.951520710038962 0.998153412295216 PE family protein PE13 IV.C.1.a - PE subfamily Rv1196 PPE18 771.6 495.5 463.1 824.9 706.8 530.9 1190.08315253449 0.0469094665098724 0.175150871499541 0.267823197842298 0.788835413531536 0.963989543249515 PPE family protein PPE18 IV.C.2 - PPE family Rv1197 esxK 1078.5 1113.8 974.7 850.1 1848.6 1583 615.247916625523 0.193985755920749 0.302386585215551 0.641515746416031 0.521187653653608 0.916731142491682 ESAT-6 like protein EsxK (ESAT-6 like protein 3) V - Conserved hypotheticals Rv1198 esxL 1302.1 993.2 686.8 1544.3 1506.2 1219.8 548.60354756584 0.334906172680563 0.183639808049722 1.82371227805839 0.0681955816640061 0.520912460856883 Putative ESAT-6 like protein EsxL (ESAT-6 like protein 4) V - Conserved hypotheticals Rv1199c - 4 2.8 1.7 3.1 4.8 0 4.90767644421455 -0.209908519136668 0.957572146829957 -0.219209090230507 0.82648717470586 NA Possible transposase IV.B.1.b - IS1081 Rv1200 - 208.2 111.9 98.5 127.2 151.5 83.6 263.395279073728 -0.378984505606178 0.216486583084306 -1.75061428845496 0.0800123723664762 0.554416577209112 Probable conserved integral membrane transport protein III.A.3 - Carbohydrates, organic acids and alcohols Rv1201c dapD 222.8 137.5 117.7 184.4 167.3 147.1 248.573221079674 -0.113269305777609 0.201701774876633 -0.561568215484905 0.574410241116108 0.925885039001838 Tetrahydrodipicolinate N-succinyltransferase DapD V - Conserved hypotheticals Rv1202 dapE 37.5 38.4 17.6 32.9 19.1 26.6 49.1530915399934 -0.413659659086789 0.368829216607903 -1.1215479697926 0.262054684637899 0.806685286411718 Probable succinyl-diaminopimelate desuccinylase DapE I.D.2 - Aspartate family Rv1203c - 7.4 8.7 0.7 7.4 12.5 6.5 5.75417115105224 0.706953055675511 0.926445837786357 0.763080826575571 0.445415193927079 NA Hypothetical protein VI - Unknowns Rv1204c - 17.7 11.3 12.5 19.4 18.2 14.7 41.8027062448734 0.126571648530634 0.361007710508597 0.350606496333045 0.725883582194067 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv1205 - 106.3 104.8 66.2 133.7 149.4 128.4 104.422907406801 0.372149773076272 0.281008196213501 1.324337788331 0.185390885828686 0.739746500217031 hypothetical protein V - Conserved hypotheticals Rv1206 fadD6 39.8 23.4 15.9 39.9 35.4 24.9 83.2185066261834 0.202793529022706 0.27784512650865 0.729879741174414 0.465463696615136 0.901158530199572 Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1207 folP2 88.9 62.6 54.3 105.8 69.9 60.8 112.44217339697 0.0297508711926161 0.266147779062647 0.111783278062272 0.910995246589263 0.992834063067731 Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2) I.G.2 - Folic acid Rv1208 gpgS 97 58.1 40.9 85.5 67.7 73 107.67154757894 0.0551329722967684 0.257435943631889 0.214161905750052 0.830420801672058 0.968638603196576 Probable glucosyl-3-phosphoglycerate synthase GpgS V - Conserved hypotheticals Rv1209 - 192.2 124.6 98.6 207.9 148.5 149.3 89.6838959505416 0.123559367918818 0.272114421814653 0.45407136856193 0.64977746000155 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv1210 tagA 122.5 77.2 60.7 111.9 116.1 94.2 94.6558809461605 0.136324631022339 0.262208744549338 0.519908789680686 0.603127148828198 0.931398768888358 Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1211 - 2031.7 1331.9 1182.3 1601.3 1581.9 1844.7 591.661807577526 -0.0324790629693651 0.208417500799077 -0.155836543691579 0.876161864802562 0.980703859230131 hypothetical protein V - Conserved hypotheticals Rv1212c glgA 15.6 13.2 5.5 14.3 8.7 4.9 18.4855148569339 -0.355646392094456 0.531803516862299 -0.668755246661041 0.503651619195029 NA Putative glycosyl transferase GlgA II.C.5 - Other membrane proteins Rv1213 glgC 112.2 77.5 55.5 90.2 69.4 92.9 162.516131931781 -0.126623981997814 0.244484280240552 -0.517922795990102 0.604512136330391 0.93157071158313 Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase) I.C.1 - General Rv1214c PE14 37.3 17.7 3.2 24.7 37.7 21.8 11.1089274286754 0.471253346460492 0.707066866925377 0.666490495460068 0.505097636784334 NA PE family protein PE14 IV.C.1.a - PE subfamily Rv1215c - 30.9 17.1 14.3 34.4 29 13.7 60.1886666871023 0.169314252770632 0.328105981593877 0.516035251622464 0.605829788628382 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv1216c - 39.3 7.7 8 28.9 30.1 25.5 23.1281749931096 0.48764996178733 0.516308787066108 0.944492857769031 0.344917849913583 NA Probable conserved integral membrane protein V - Conserved hypotheticals Rv1217c - 21.3 15.6 9.5 16.5 15.5 9.9 37.8701707185574 -0.287599942759461 0.373337810494005 -0.770347751220015 0.441093637929148 0.901158530199572 Probable tetronasin-transport integral membrane protein ABC transporter II.C.5 - Other membrane proteins Rv1218c - 27 13.4 20.6 15.6 18.3 23.8 30.5652554827328 -0.38102993761908 0.445585643268581 -0.855121666003522 0.392483796345186 0.893826103932853 Probable tetronasin-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1219c - 48.1 47 29.9 40.2 35.2 35.2 40.9444414336966 -0.365052767629311 0.375388646266448 -0.972466192731357 0.330818675703429 0.853347384539607 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1220c - 117.3 71.5 45.8 123.5 126.7 98.7 98.0260507149909 0.425224328589675 0.263029634913947 1.61664037867365 0.105955930517476 0.639899789981086 Probable methyltransferase IV.H - Miscellaneous transferases Rv1221 sigE 202.2 138.1 83 198.3 359.9 228.3 245.060027127303 0.749672432198258 0.260620250154854 2.87649341044229 0.00402120591395781 0.118600096215438 Alternative RNA polymerase sigma factor SigE II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1222 rseA 488.5 254.9 255.3 488.7 468.4 304.8 275.883827879724 0.162011984181214 0.207681899652405 0.78009679443597 0.435333903143544 0.901158530199572 Anti-sigma factor RseA VI - Unknowns Rv1223 htrA 441.2 334.8 206.6 419.2 405.6 355.5 913.721251798609 0.0981279623799527 0.180968678772474 0.542237270258936 0.587655063233453 0.928941202821899 Probable serine protease HtrA (DEGP protein) II.B.3 - Proteins, peptides and glycopeptides Rv1224 tatB 302.7 218.4 181.4 263 225.2 243.8 153.204510221103 -0.13764983300647 0.238773206694584 -0.576487768087557 0.564285535314586 0.92521033104044 Probable protein TatB V - Conserved hypotheticals Rv1225c - 20.9 6.2 15.8 16.5 19.5 10.2 19.6014546359473 -0.138710322842846 0.519662884833323 -0.266923667037211 0.789527933892378 NA hypothetical protein V - Conserved hypotheticals Rv1226c - 25 9.9 16.6 25 17.5 2.1 36.3329404144237 -0.397463166459857 0.492578539414416 -0.806903132508304 0.41972229394085 0.901158530199572 Probable transmembrane protein II.C.5 - Other membrane proteins Rv1227c - 48.3 29 50.2 26.3 24.2 26.2 30.8548935848759 -1.04553896895232 0.457049687209422 -2.28758272505556 0.0221618328590459 0.308038340141311 Probable transmembrane protein II.C.5 - Other membrane proteins Rv1228 lpqX 12.2 16.8 1.9 16.1 0 9.5 8.12486893199232 -0.25616777636852 0.909015034320473 -0.281808074340614 0.778090679333977 NA Probable lipoprotein LpqX II.C.1 - Lipoproteins(lppA-lpr0) Rv1229c mrp 164 72.6 84.6 151.6 109.2 99 210.19446957304 -0.0032853700672789 0.232199773655055 -0.0141488943574919 0.988711192294332 0.999120249206713 Probable Mrp-related protein Mrp V - Conserved hypotheticals Rv1230c - 47.8 24.2 26.5 32.5 30.1 21.6 59.6967690015658 -0.414604246495251 0.314451829445341 -1.31849843973421 0.187336847019219 0.739746500217031 Possible membrane protein II.C.5 - Other membrane proteins Rv1231c - 110.8 112.8 87 105.8 87.6 74 86.298617792385 -0.443613078163644 0.304997548440737 -1.45448079970335 0.145813052890168 0.693983707603282 Probable membrane protein VI - Unknowns Rv1232c - 80.6 27.9 34 79.2 66.7 26.8 104.517077773521 0.128590971552826 0.31744391982312 0.405082483937561 0.685416881357549 0.942913432418385 hypothetical protein VI - Unknowns Rv1233c - 234.4 167.5 101.8 165.5 206 149.3 162.130906869351 -0.114523837139617 0.239502061633882 -0.47817474454431 0.632525836401038 0.93413540068838 hypothetical protein VI - Unknowns Rv1234 - 125.7 78.8 72.1 109.9 94.8 123.7 85.9548668234959 0.0467627520425841 0.287982006193875 0.162380812123041 0.871005980010952 0.977891032682394 Probable transmembrane protein VI - Unknowns Rv1235 lpqY 35.6 22.4 23.7 29.5 30.4 26.7 63.7227810757579 -0.120602155218231 0.310657626233605 -0.388215659407446 0.697856445658428 0.945284490054462 Probable sugar-binding lipoprotein LpqY II.C.1 - Lipoproteins(lppA-lpr0) Rv1236 sugA 46.2 17.7 24.2 42.1 48 32.1 50.2383852660429 0.294124578831286 0.345458860666359 0.85140261929871 0.394545737241472 0.893826103932853 Probable sugar-transport integral membrane protein ABC transporter SugA III.A.3 - Carbohydrates, organic acids and alcohols Rv1237 sugB 76.7 43.3 39.5 55 43.3 38.7 64.5671533272693 -0.390046836814744 0.302609576905616 -1.28894412663086 0.197417511794953 0.751109817915875 Probable sugar-transport integral membrane protein ABC transporter SugB III.A.3 - Carbohydrates, organic acids and alcohols Rv1238 sugC 112.7 60.5 73.1 100.5 135.2 79.3 177.029691992059 0.143062947437045 0.25166982961406 0.568454898453401 0.569726122287183 0.92521033104044 Probable sugar-transport ATP-binding protein ABC transporter SugC III.A.3 - Carbohydrates, organic acids and alcohols Rv1239c corA 14.5 11 9.3 12.8 13.4 5.8 18.834230623442 -0.28446058184624 0.509936482489739 -0.557835321876512 0.576956840547644 NA Possible magnesium and cobalt transport transmembrane protein CorA III.A.2 - Cations Rv1240 mdh 108.3 67 42 151.1 82.9 80.7 136.122122290592 0.406963722907631 0.269041374036271 1.51264363841959 0.130370203190559 0.67528835585222 Probable malate dehydrogenase Mdh I.B.3 - TCA cycle Rv1241 vapB33 92 71.9 28.2 135.3 78.4 46.7 29.8273983046298 0.356959590522426 0.449612206047863 0.793927713084432 0.427237515132542 0.901158530199572 Possible antitoxin VapB33 V - Conserved hypotheticals Rv1242 vapC33 53.1 44.9 34.7 42.6 51.7 38.3 30.4870832349812 -0.21156585408487 0.414575460435289 -0.510319288707377 0.609827791528019 0.931582271037618 Possible toxin VapC33 Contains PIN domain V - Conserved hypotheticals Rv1243c PE_PGRS23 6.2 3.7 4.7 3.1 2.2 3.5 10.6158380664525 -1.09293794289421 0.680062705319521 -1.60711348283789 0.108029476154708 NA PE-PGRS family protein PE_PGRS23 IV.C.1.b - PE_PGRS subfamily Rv1244 lpqZ 39 16.2 9.3 52.7 22.8 16.2 32.7414719810622 0.440083963011744 0.466020292907127 0.944345063315618 0.344993344997534 0.858763247037453 Probable lipoprotein LpqZ II.C.1 - Lipoproteins(lppA-lpr0) Rv1245c - 67.4 32.1 48.6 41.8 36.6 31.9 58.0333558341929 -0.648205146611086 0.33966753116201 -1.90835180623111 0.0563457613341624 0.490101810849978 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1246c relE 52.3 19.5 29.7 38.1 61.2 25.7 16.8291267511915 0.0838336558376939 0.546731996425417 0.153335923973365 0.878133372403292 NA Toxin RelE V - Conserved hypotheticals Rv1247c relB 109.8 84.8 74.6 87.7 161.2 163.2 49.606343922756 0.368099216118576 0.387625674890464 0.9496254762345 0.342302588780056 0.855368447926409 Antitoxin RelB V - Conserved hypotheticals Rv1248c - 127.2 67.5 72.3 103.3 106.9 80.6 550.199674743062 -0.0625332592405131 0.189234702607346 -0.330453444209263 0.74105736470557 0.955781054558401 Multifunctional alpha-ketoglutarate metabolic enzyme I.B.3 - TCA cycle Rv1249c - 74.1 33.1 31.3 74.3 69.4 46.1 66.5232432252142 0.297393616387826 0.304211612546172 0.977587981927184 0.328278143689888 0.853347384539607 Possible membrane protein II.C.5 - Other membrane proteins Rv1250 - 13.4 5.2 5.8 7.8 10.1 13 24.6857541693093 0.116820128976074 0.477209406140641 0.244798462630565 0.806612484352135 NA Probable drug-transport integral membrane protein III.A.6 - Efflux proteins Rv1251c - 14.3 6.3 8.8 11.5 14 11.9 60.189061020614 0.128253647336783 0.328898427141328 0.389949105112843 0.696574181799048 0.944379447746764 hypothetical protein VI - Unknowns Rv1252c lprE 16.2 2.8 6.5 12.4 28.9 13 11.5015910145371 0.814799599083027 0.691072320309838 1.17903665815716 0.238383579030959 NA Probable lipoprotein LprE II.C.1 - Lipoproteins(lppA-lpr0) Rv1253 deaD 52.8 33.3 26.4 40.2 38.8 39.1 103.714087928552 -0.117001088207273 0.258331457593754 -0.45291072677361 0.650613026498696 0.939577115195416 Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1254 - 52 16.9 13.7 41.6 32.3 38.6 56.6834926348552 0.344046100855653 0.361597018706341 0.951462769484444 0.341369509400857 0.855368447926409 Probable acyltransferase IV.H - Miscellaneous transferases Rv1255c - 24 16.8 20.7 22.1 29 12.3 20.0986134588863 -0.146278361843758 0.508341770392324 -0.287755935796627 0.773533569412505 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1256c cyp130 28.2 19.6 10.5 20.4 28 24 41.7575597861109 0.115971544390555 0.37289769450246 0.311000969167404 0.7557998848541 0.959593750764785 Probable cytochrome P450 130 Cyp130 IV.F - Cytochrome P450 enzymes Rv1257c - 89.6 40.3 47.6 102.8 81.3 60.9 151.050794701282 0.293671695790416 0.245815923556676 1.19468133529074 0.232211557546952 0.78809468487714 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1258c - 8.1 9 0 13.5 5.9 12.6 15.6105891892601 0.826299056374611 0.681257802321611 1.21290215474777 0.225167231733042 NA Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv1259 udgB 10.8 2.6 4.8 6 4.6 5.6 7.6278069943387 -0.3680976035849 0.779680261318567 -0.472113534030458 0.636845752672777 NA Probable uracil DNA glycosylase, UdgB VI - Unknowns Rv1260 - 80.8 66.1 39 58.9 81.9 73.2 119.882975039039 0.0240098122531734 0.277950694389429 0.0863815516126536 0.931163111788434 0.998010361628995 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1261c - 231.6 219.2 118 178.6 308.1 262.7 159.955995858431 0.216860369275949 0.292685160099336 0.740933941448713 0.458733494538833 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1262c - 118.3 47.1 71.4 99 120.3 50.2 57.1697406182408 -0.015131328951572 0.352611095072765 -0.0429122315293269 0.965771498382642 0.998153412295216 Hypothetical hit-like protein V - Conserved hypotheticals Rv1263 amiB2 8.8 6.2 5 9.9 12 9.2 18.2924020186737 0.460263769647812 0.504978287446725 0.911452593288716 0.362056953183084 NA Probable amidase AmiB2 (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1264 - 219.1 127.4 141.7 195.7 158 113.2 306.461943694429 -0.271827844642001 0.218133458500633 -1.24615382945122 0.212707925758473 0.773070552038584 Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase) IV.J - Cyclases Rv1265 - 369.2 279.5 151.3 271.9 284.4 281.8 297.169426172414 -0.0884810974713472 0.222979401008867 -0.396812876306133 0.691505454736802 0.942913432418385 hypothetical protein VI - Unknowns Rv1266c pknH 36.2 31.1 15.2 32.6 34.9 28.2 88.7126953325592 0.0603928880752542 0.286271766548581 0.21096347992461 0.832915768791143 0.969702342452218 Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1267c embR 7.2 7 2 8.4 8.6 1.7 9.83572023115421 0.226635877202805 0.708968094098172 0.319670065676358 0.749218454113057 NA Probable transcriptional regulatory protein EmbR I.J.1 - Repressors/activators Rv1268c - 6 0 2.1 1.6 6 0.4 2.35421548634957 -0.507320406201444 1.43208787851628 -0.354252287036361 0.723149821528617 NA Hypothetical protein VI - Unknowns Rv1269c - 18 14.2 11.2 10.4 16.2 7.4 7.20240634773719 -0.693280686383328 0.794303436029999 -0.872815922650931 0.382763419337593 NA Conserved probable secreted protein V - Conserved hypotheticals Rv1270c lprA 33.2 36 20 29.1 24 23.1 32.7229434881416 -0.393805859824497 0.414014936570939 -0.951187566048167 0.341509169199004 0.855368447926409 Possible lipoprotein LprA II.C.1 - Lipoproteins(lppA-lpr0) Rv1271c - 55.5 67.8 28.6 31.2 96 110.8 36.2544362409003 0.452237984561798 0.504909141325409 0.8956819109566 0.37042267418326 0.885048465556592 Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1272c - 48.3 35.3 20.8 46.5 46.6 36.8 116.812755273766 0.162678502870676 0.251156665814541 0.647717241917845 0.517167850352196 0.915911629458156 Probable drugs-transport transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1273c - 20.3 19.8 8.1 24.2 20.8 8.6 45.7790390906137 0.00857589542654034 0.388102185003653 0.0220970037219956 0.982370576577239 0.998667985896356 Probable drugs-transport transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1274 lprB 157.5 110.4 81.9 162 125.5 66.2 103.170734951327 -0.146052770747583 0.282022256172119 -0.517876754586513 0.604544261493752 0.93157071158313 Possible lipoprotein LprB II.C.1 - Lipoproteins(lppA-lpr0) Rv1275 lprC 134.4 74.4 54.7 130.3 116.5 116.1 89.1349784385044 0.306513266458663 0.271741898640772 1.12795733006877 0.259337940094815 0.803279666631868 Possible lipoprotein LprC II.C.1 - Lipoproteins(lppA-lpr0) Rv1276c - 6.7 0 2.5 1.8 3.4 0 1.28207277086328 -1.04447792364691 1.84993043770899 -0.564603891236266 0.572343217954729 NA hypothetical protein VI - Unknowns Rv1277 - 23.6 15.1 14.2 24.1 19.2 19.1 38.3270828113475 0.0603856752143568 0.369264067032181 0.163529789669717 0.8701013200722 0.977891032682394 hypothetical protein VI - Unknowns Rv1278 - 29.1 20.1 12.8 28.7 20.4 18 88.6542642964615 -0.0277060061362498 0.277218876098281 -0.099942711427873 0.920389807265491 0.9932884147079 Hypothetical protein VI - Unknowns Rv1279 - 72.8 43.9 40.7 52.8 57.8 38.2 129.495424767067 -0.274766662102053 0.243767732280061 -1.12716584566811 0.259672367977097 0.803415849915716 Probable dehydrogenase FAD flavoprotein GMC oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1280c oppA 104.3 69.4 58.9 86 99.8 87.9 241.052846685262 0.0397630683609813 0.217159629075031 0.183105250871665 0.854715435830341 0.975712312098852 Probable periplasmic oligopeptide-binding lipoprotein OppA III.A.1 - Amino acids Rv1281c oppD 28.8 17.8 13.8 33.8 34.3 13.7 66.8925399151454 0.275326832923515 0.320106736628968 0.860109461684474 0.389728706068518 0.893826103932853 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD III.A.1 - Amino acids Rv1282c oppC 32.2 26.7 16.3 35.2 33.3 38.8 42.594853513185 0.352172605274294 0.364076328995527 0.967304318426646 0.333391925539927 0.853347384539607 Probable oligopeptide-transport integral membrane protein ABC transporter OppC III.A.1 - Amino acids Rv1283c oppB 34.6 24.2 20 35.7 28.9 28.8 44.402829108211 0.070234542495856 0.347518509092025 0.202103026625432 0.83983618178562 0.973720332492836 Probable oligopeptide-transport integral membrane protein ABC transporter OppB III.A.1 - Amino acids Rv1284 canA 9.2 1.1 4.4 5 16 21.7 7.08593428741812 1.32998723788589 0.919404180445843 1.44657514744053 0.148015950967343 NA Beta-carbonic anhydrase V - Conserved hypotheticals Rv1285 cysD 80.4 46.1 39.9 64 41.1 40.2 82.1588088817005 -0.343321701064033 0.286202486866846 -1.19957623297579 0.230303961584878 0.784923331661854 Probable sulfate adenylyltransferase subunit 2 CysD I.C.5 - Sulphur metabolism Rv1286 cysN 42.9 26 43.3 18.2 21.8 23 92.9388207327816 -1.13309199567479 0.345712253380478 -3.27755809808613 0.0010470917973001 0.0499354467471048 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase I.C.5 - Sulphur metabolism Rv1287 - 79.3 45.9 39.3 61 79.7 31.1 41.8743268971591 -0.122758250847084 0.370814734307405 -0.331050089140518 0.740606650949857 0.955781054558401 hypothetical protein V - Conserved hypotheticals Rv1288 - 16.9 13.4 3.4 13.6 12.7 4.1 21.7463145545499 -0.218731378552325 0.524041613377656 -0.41739314773595 0.676390866095858 NA hypothetical protein V - Conserved hypotheticals Rv1289 - 101.6 62.5 65.4 93.7 88.2 78.9 83.2905147007634 -0.0219704384261208 0.281523119022418 -0.0780413292606753 0.937795177228455 0.998153412295216 hypothetical protein VI - Unknowns Rv1290c - 28.6 17.6 13.5 27.8 24.9 22.2 55.0273474949591 0.172963649956017 0.31609536972543 0.547188179650523 0.584249456107698 0.928941202821899 hypothetical protein VI - Unknowns Rv1290A - 3.1 0 6.8 6.2 5.9 0 1.60128776964476 -0.265808754707188 1.68995028631228 -0.157287913650538 0.875017945208375 NA Hypothetical protein ? Rv1291c - 3.2 10 0 1.1 5.3 0 1.54908635353566 -1.48752157304688 1.81196762619789 -0.820942687683769 0.41167891437487 NA Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1292 argS 72.1 56.6 37.2 63.4 63.7 52.2 152.370888270261 -0.0660898432634733 0.235033897607813 -0.281192814892401 0.778562515315552 0.963013023606306 Probable arginyl-tRNA synthetase ArgS (ARGRS) (arginine--tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1293 lysA 180.6 107.9 65.2 172 128.5 110.9 267.066131138356 0.0854344104502473 0.217395760599154 0.392990232260213 0.694326695729452 0.943825877173016 Diaminopimelate decarboxylase LysA (DAP decarboxylase) I.D.2 - Aspartate family Rv1294 thrA 240.5 131.3 115 245 186.3 166.1 377.565508738703 0.134704265016353 0.192475086491142 0.699852991221033 0.484019117308732 0.908019273666837 Probable homoserine dehydrogenase ThrA I.D.2 - Aspartate family Rv1295 thrC 208.9 102.5 100.3 209.1 124.9 120.6 245.688192055018 -0.0127176875828771 0.232190177444654 -0.0547727200299357 0.956319534029373 0.998153412295216 Threonine synthase ThrC (ts) I.D.2 - Aspartate family Rv1296 thrB 93.5 43.2 30.1 72.8 51.1 64.1 86.595973140198 0.0425527202190841 0.297188943914254 0.143184062161348 0.886144816673551 0.982420376752145 Probable homoserine kinase ThrB I.D.2 - Aspartate family Rv1297 rho 1116.4 794.1 585.5 838.6 1133.6 867 2590.98029632157 0.0129883542068471 0.188608875739212 0.068863960701436 0.945097905583902 0.998153412295216 Probable transcription termination factor Rho homolog II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1298 rpmE 2428.8 2259.7 1386.4 1681.1 3124.4 3000.6 921.194690819368 0.191322619665724 0.271751210976924 0.704035941469897 0.48141039110057 0.907292899730371 50S ribosomal protein L31 RpmE II.A.1 - Ribosomal protein synthesis and modification Rv1299 prfA 223.4 143.1 156.7 254.7 214.1 179.4 338.407515751756 0.0917878679660114 0.21284205233558 0.431248745061398 0.666287514138445 0.940354944889996 Probable peptide chain release factor 1 PrfA (RF-1) II.A.6 - Protein translation and modification Rv1300 hemK 281.9 199.7 129 261 272.8 236 357.697420291381 0.171408348007274 0.196966184920957 0.870242514348647 0.384167886798591 0.893826103932853 Probable HemK protein homolog HemK I.G.12 - Heme and porphyrin Rv1301 - 221 119.7 151.3 251.3 226.3 141.7 193.006349286302 0.120371599792774 0.245026815081452 0.491258884268482 0.623243356110953 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv1302 rfe 64.4 36.1 40.1 64.1 66.6 69 110.650729826796 0.306779052069798 0.267908656250634 1.14508824150422 0.252172605845615 0.796502243851669 Probable undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe (UDP-GlcNAc transferase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1303 - 660.8 371.1 242.4 371.4 327.6 301.5 290.94396523223 -0.479512830722943 0.207542826292987 -2.31042835489778 0.020864450784054 0.297479746745841 hypothetical protein V - Conserved hypotheticals Rv1304 atpB 738.9 627.6 464.4 388.2 543.9 507.8 681.180700798599 -0.545512510284482 0.230084308108769 -2.37092444403726 0.0177436578891681 0.276757764055105 Probable ATP synthase a chain AtpB (protein 6) I.B.8 - ATP-proton motive force Rv1305 atpE 1315.1 887.6 711.5 905.2 1262.2 909.9 395.889223360032 -0.108503778048084 0.211139668460903 -0.513895748908862 0.607324879814712 0.931582271037618 Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) I.B.8 - ATP-proton motive force Rv1306 atpF 1373.5 911.8 800.1 846.9 964.3 858.2 807.125671719498 -0.397080425217235 0.188223432617182 -2.10962269519777 0.0348908679016298 0.39160811058244 Probable ATP synthase B chain AtpF I.B.8 - ATP-proton motive force Rv1307 atpH 1010.9 688.4 654.6 655.9 743.4 658.6 1619.76540340848 -0.39588934519979 0.189285727802987 -2.09149073094322 0.0364840964639475 0.398982485820102 Probable ATP synthase delta chain AtpH I.B.8 - ATP-proton motive force Rv1308 atpA 897 538.6 489.6 605.6 663.8 630.8 1701.94543934742 -0.184851617127715 0.180697167449023 -1.02299122746273 0.30631199360131 0.844880251285152 Probable ATP synthase alpha chain AtpA I.B.8 - ATP-proton motive force Rv1309 atpG 759.3 509.7 448.1 575.1 574.9 511.1 839.596473210689 -0.23982862188347 0.178153772706252 -1.34618884708611 0.178241620967117 0.734764437650925 Probable ATP synthase gamma chain AtpG I.B.8 - ATP-proton motive force Rv1310 atpD 963.5 594.7 477.1 895.5 771.9 640.8 1682.73032970059 0.0108605435599893 0.157192918614064 0.0690905395468472 0.944917551382588 0.998153412295216 Probable ATP synthase beta chain AtpD I.B.8 - ATP-proton motive force Rv1311 atpC 1330.4 814.9 608.9 1347.4 871.7 855.5 562.249599200408 -0.000915430010734394 0.195729135444036 -0.00467702474982903 0.996268287766551 0.999833281786427 Probable ATP synthase epsilon chain AtpC I.B.8 - ATP-proton motive force Rv1312 - 502.3 330.7 241.3 437.6 399.3 266.5 255.081160217198 -0.128312459484732 0.206081952040834 -0.622628319530416 0.533528796790615 0.923128239106977 Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1313c - 34.5 12.8 9.2 34.3 32 10.6 43.7840338562685 0.344388082697412 0.406601111406475 0.846992477482756 0.396999314413792 0.893826103932853 Possible transposase IV.B.1.c - Others Rv1314c - 54.2 46.8 26.2 57 52.3 60.6 45.6342276611689 0.245546724528537 0.355360744777562 0.690978753666889 0.48957889296212 0.910063990546522 hypothetical protein V - Conserved hypotheticals Rv1315 murA 60.9 39.1 21.3 67 60.4 31.8 90.0430811955776 0.266459721943871 0.29172993494189 0.913378059735103 0.361043740653261 0.882466185309938 Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA II.C.3 - Murein sacculus and peptidoglycan Rvnr01 rrs 11779.3 10136.9 12635.9 53592.5 9611.8 8523 42381.1217756791 0.655729254109249 0.885040121816254 0.740903421150649 0.458752001008335 0.901158530199572 16S rRNA ? Rv1316c ogt 50.5 45.9 24.4 22 23.9 25.6 25.6466405642165 -1.00288984625449 0.461510094210788 -2.17306156210841 0.0297756841957029 NA Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1317c alkA 33.3 24 15.3 32.5 28.8 11.5 56.2913836759353 -0.123044510130672 0.340647169598545 -0.361208080124902 0.71794390226794 0.949890877982223 Probable bifunctional regulatory protein and DNA repair enzyme AlkA (regulatory protein of adaptative response) (methylphosphotriester-DNA--protein-cysteine S-methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1318c - 16.1 19 8 14.9 12.9 6.5 33.5718700180286 -0.433945349704927 0.42710812113402 -1.01600819144519 0.309625485807204 0.844880251285152 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1319c - 43.3 21.2 21.2 31.3 27.3 23.1 70.4928152845024 -0.249945709325028 0.293291544981 -0.852209051376576 0.394098073790325 0.893826103932853 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1320c - 140.7 82.1 74.5 85.1 110.7 73.9 258.891909479267 -0.323260553687468 0.216138122492421 -1.49562025412154 0.134752642022236 0.681400014320852 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1321 - 118.1 71.9 65.8 79.3 72.7 108.4 95.0338569731818 -0.178675971711443 0.295361984931711 -0.604938959063243 0.545219555765311 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv1322 - 95.2 64.2 48 70.5 96.9 88.5 36.5155946054693 0.0976610284641594 0.388229874647518 0.251554645434816 0.8013853190796 0.965592404376002 hypothetical protein VI - Unknowns Rv1322A - 5027.5 3081.1 2476.8 2853.6 3471.7 2552.8 2396.09502146816 -0.417691871862376 0.169790299994969 -2.46004554956763 0.0138919383359664 0.260180903193056 hypothetical protein ? Rv1323 fadA4 610.6 436 316.1 495.5 525.6 429.8 882.387446216924 -0.0876079854010985 0.174667447658672 -0.501570192817487 0.615969890907222 0.931582271037618 Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv1324 - 708.7 452.2 281.6 588.8 475.7 305.2 673.252176843255 -0.229437455582475 0.200709796421921 -1.14313032882642 0.252984483691672 0.796502243851669 Possible thioredoxin VI - Unknowns Rv1325c PE_PGRS24 23.4 12.1 12.1 33.1 15.3 16.5 52.8532769006868 0.29457760429306 0.356778865620396 0.825658783854321 0.408997678936171 0.901158530199572 PE-PGRS family protein PE_PGRS24 IV.C.1.b - PE_PGRS subfamily Rv1326c glgB 122.5 69.3 62.2 88.6 81.8 72.8 291.620838034618 -0.232623337026004 0.196324310760137 -1.18489318070351 0.236059683967136 0.78958848015113 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) II.A.8 - Polysaccharides (cytoplasmic) Rv1327c glgE 138.1 80.6 106.7 86.3 125.7 106.7 373.975228231631 -0.257913137712994 0.255742259976535 -1.00848853739174 0.313219987833485 0.846061021823653 Probable glucanase GlgE II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1328 glgP 79.2 47.9 41.6 80.2 57.4 44.8 240.684131591015 -0.0589697161124374 0.217151717556657 -0.271559980164796 0.785960374556156 0.963989543249515 Probable glycogen phosphorylase GlgP II.A.8 - Polysaccharides (cytoplasmic) Rv1329c dinG 24.3 16.1 13.1 21.2 22 22.3 62.9800647723611 0.109661548217375 0.308763288283073 0.355163817651915 0.722466869311007 0.949890877982223 Probable ATP-dependent helicase DinG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1330c pncB1 25.2 14.2 20.1 23.2 13.6 12.5 39.4237132800538 -0.489993450110207 0.401950165891249 -1.21904029825125 0.222828897704319 0.774556499980442 Nicotinic acid phosphoribosyltransferase PncB1 V - Conserved hypotheticals Rv1331 - 960.4 589.4 405.3 1377.2 739.4 749.6 383.079250858388 0.402056298547905 0.228829646278646 1.7570114060235 0.0789158650686905 0.55131591065269 hypothetical protein V - Conserved hypotheticals Rv1332 - 639.3 380.3 304.9 612.6 482.3 345.3 477.642938586396 -0.0479758954325641 0.190747141641755 -0.251515671583003 0.801415447370708 0.965592404376002 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1333 - 170.1 88.5 74.3 145.7 81.8 80 173.290699704758 -0.254690425527654 0.251036934665839 -1.01455359892232 0.310318667459508 0.844880251285152 Probable hydrolase II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1334 mec 276.5 231.7 196 238.8 248.5 226.3 170.761418233058 -0.205608134692431 0.245414420899101 -0.837799726434838 0.402143192428361 0.893826103932853 Possible hydrolase V - Conserved hypotheticals Rv1335 cysO 335.1 187 199.4 240.2 215.4 189.3 103.53200778057 -0.361567849439659 0.262055080591696 -1.37973989522841 0.16766674457188 0.725041090026968 Sulfur carrier protein CysO V - Conserved hypotheticals Rv1336 cysM 309 166.5 175.3 254.4 225 192.5 343.531245650044 -0.136411632480074 0.198239437846958 -0.688115513046324 0.491380042172 0.912135536464192 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) I.D.3 - Serine family Rv1337 - 258.4 166.9 133.5 219.3 176.3 126.8 208.073841829687 -0.262664402355895 0.217379301186664 -1.20832296783559 0.226923057238194 0.780210909201606 Probable integral membrane protein V - Conserved hypotheticals Rv1338 murI 161.2 98.9 86.9 123.9 128.2 127.9 159.160162622672 -0.0597878633540666 0.234556767025267 -0.254897200845312 0.798802498279582 0.965592404376002 Probable glutamate racemase MurI II.C.3 - Murein sacculus and peptidoglycan Rv1339 - 263.3 148.7 108.9 223.2 224 199.3 252.132145177893 0.163074793621731 0.206190983211791 0.790891973458548 0.429007032646164 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1340 rphA 181.6 124.9 61.3 180.2 134.3 108.3 159.884116972554 0.0716619376667644 0.252751713888958 0.28352700982375 0.7767728798888 0.963013023606306 Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase) II.B.1 - RNA Rv1341 - 76.2 44.6 42.4 96.3 60.2 61.5 61.4897545535643 0.260590547797033 0.316639458457068 0.822988231052591 0.410514686099629 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1342c - 53.4 24.9 36.6 33.9 40.3 38.2 21.9626676479173 -0.255112212647848 0.483001216493145 -0.52818130459402 0.597373504001769 NA hypothetical protein I.I - Polyketide and non-ribosomal peptide synthesis Rv1343c lprD 48.4 31 27.5 31.3 27.3 15.8 18.0485417088433 -0.691154813522741 0.518258348963995 -1.33361057261184 0.182331516189394 NA Probable conserved lipoprotein LprD V - Conserved hypotheticals Rv1344 mbtL 44.8 21.1 15.8 60.1 31.5 26.9 15.8895135514412 0.488705611926397 0.558162730723774 0.875561167068049 0.381268644060569 NA Acyl carrier protein (ACP) MbtL I.H.1 - Synthesis of fatty and mycolic acids Rv1345 mbtM 39.7 20.6 19.7 52.5 29.3 32 79.0689485300863 0.34629792300371 0.300526671059679 1.15230346039717 0.249196395510015 0.796128980119145 Probable fatty acyl-AMP ligase MbtM I.A.3 - Fatty acids Rv1346 mbtN 58.4 48.4 35.3 65 57.7 64 102.445843715 0.201889744758048 0.272093119917369 0.741987687227665 0.458094795688539 0.901158530199572 Acyl-CoA dehydrogenase MbtN I.A.3 - Fatty acids Rv1347c mbtK 9.1 4.3 10.5 5.4 12.8 4.5 7.52204836363639 -0.460874060470256 0.826414446711766 -0.557679094677054 0.577063535457231 NA Lysine N-acetyltransferase MbtK IV.D - Antibiotic production and resistance Rv1348 irtA 8.9 6 5.3 6.1 7.3 1.1 23.2693205566316 -0.692243236640411 0.499723194591963 -1.38525336452643 0.165975008272719 NA Iron-regulated transporter IrtA II.C.5 - Other membrane proteins Rv1349 irtB 6.5 7.8 3.2 9.7 7.7 4.8 17.6159678173444 0.205677888895169 0.54064419756696 0.380431140888543 0.703625402150069 NA Iron-regulated transporter IrtB II.C.5 - Other membrane proteins Rv1350 fabG2 49.3 36.8 22.3 51.3 73.9 50.3 55.1800086342239 0.537020897618457 0.334533090283451 1.60528483793169 0.108431134355108 0.643080319504058 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv1351 - 81.4 59.5 28.8 54.8 97 76.3 33.8551956250265 0.219102788565631 0.421175647792888 0.520217134380414 0.602912244226984 0.931398768888358 Hypothetical protein VI - Unknowns Rv1352 - 124.9 76.6 70.2 88.7 79.4 152.2 59.5729580581396 0.0296985536805924 0.361404079062509 0.0821754800267643 0.934507171590419 0.998010361628995 hypothetical protein V - Conserved hypotheticals Rv1353c - 8.3 3.8 2.2 7.1 11.5 17.9 9.82513786831427 1.26946935645961 0.751670588655748 1.68886394601373 0.0912455059404556 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1354c - 10.1 9.4 7.5 7.9 17.9 14.8 34.2684656760734 0.349588458766555 0.449923484758053 0.77699535723179 0.437161509505431 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1355c moeY 12.7 8.4 5.8 7 1.1 11.5 26.9500953608052 -0.662343810174175 0.533230026516451 -1.24213524602358 0.21418666618162 0.773070552038584 Possible molybdopterin biosynthesis protein MoeY I.G.4 - Molybdopterin Rv1356c - 3.6 2.2 3.2 4.9 4.4 7.2 4.81661202495489 0.78365716940363 0.955231335306051 0.820384696815406 0.411996836604684 NA Hypothetical protein VI - Unknowns Rv1357c - 0.2 0.9 0 1.2 1 0 0.245548313581191 1.46607076756067 3.88149465857953 0.377707789528994 0.705647680541539 NA hypothetical protein V - Conserved hypotheticals Rv1358 - 2.9 2.5 3.1 1.7 3.8 4.9 18.4133937148088 0.0277829870300951 0.589333098270079 0.0471430963433904 0.962399179586932 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1359 - 7.5 8.3 7.6 7.1 7.4 10.4 9.74729301185714 -0.180354897339517 0.702430667962676 -0.256758290270293 0.797365370357459 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1360 - 320 235.8 166.3 255.1 277.9 262.7 417.801724675766 -0.035849566996395 0.201465324399682 -0.177944105782065 0.858766872151129 0.975793048425672 Probable oxidoreductase IV.G - Coenzyme F420-dependent enzymes Rv1361c PPE19 158.6 94.9 75.9 181.8 210.4 120.3 261.404986426737 0.469029968681418 0.212574697450724 2.20642425606718 0.0273543082349776 0.351916356176503 PPE family protein PPE19 IV.C.2 - PPE family Rv1362c - 42.2 28.8 12.6 44 47.7 43.1 36.6888423863407 0.544638948889199 0.39062179159371 1.39428716116198 0.163230906361317 0.721240714050165 Possible membrane protein V - Conserved hypotheticals Rv1363c - 57.4 59 52.7 63.5 88.1 84.7 87.7265170792499 0.240077475600952 0.330553661685354 0.726288961304793 0.467661645051662 0.902058654262829 Possible membrane protein V - Conserved hypotheticals Rv1364c - 36.8 33.1 15.4 34.4 46.9 43.8 109.762056130758 0.392846189071862 0.294699134362863 1.33304154395021 0.182518170868475 0.736194517318001 Possible sigma factor regulatory protein II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1365c rsfA 45.2 16.3 6.7 28.7 28.4 20.3 13.3463277958974 -0.00475421509636642 0.62105058592359 -0.00765511731914113 0.993892159734057 NA Anti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A) V - Conserved hypotheticals Rv1366 - 15 16.1 12.7 13.4 22.1 22.4 22.388367121054 0.137136559849537 0.504787914390473 0.271671638603172 0.785874510472182 NA Hypothetical protein VI - Unknowns Rv1366A - 55.1 57.5 26 33.8 39.4 13.1 15.4552000085611 -0.789561564365222 0.574262532296577 -1.37491394607903 0.169158125107558 NA hypothetical protein ? Rv1367c - 19 7.5 8.7 27.5 17.5 10.1 25.3827007808072 0.480317186222784 0.466572356918486 1.02945915912181 0.303263961889348 NA hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv1368 lprF 95.4 82.3 48.9 77.2 78.3 94.8 100.809377110157 -0.046565707272632 0.286666568988309 -0.162438569090807 0.870960500396592 0.977891032682394 Probable conserved lipoprotein LprF II.C.1 - Lipoproteins(lppA-lpr0) Rv1369c - 5.6 6 1.7 1.5 3.2 5.8 5.6232330438989 -0.773960907003217 0.9652755469402 -0.801803080432912 0.422666876482109 NA Probable transposase IV.B.1.a - IS6110 Rv1370c - 10.8 10.2 0 11.5 17.4 12 4.8457966363148 0.856902828248747 0.991432562898941 0.864307730364605 0.387418864704316 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1371 - 1.3 1.2 0 2.1 1.3 1.9 2.13657506545118 0.955326498978966 1.42984399152095 0.668133380035934 0.504048456100599 NA Probable conserved membrane protein VI - Unknowns Rv1372 - 31.6 15.1 14 36.3 60.1 49.5 63.4253634176865 1.09114201002466 0.341891218672244 3.1914888433291 0.00141541577286221 0.0611725004333888 hypothetical protein I.I - Polyketide and non-ribosomal peptide synthesis Rv1373 - 29.2 15.1 15.2 18.3 29 5.2 28.4949197823984 -0.353507931106049 0.455075589184045 -0.776811456180042 0.437270016761379 0.901158530199572 Glycolipid sulfotransferase IV.H - Miscellaneous transferases Rv1374c - 6.3 3.8 2.4 2.3 12.1 6.2 3.22335858098433 0.609617034510599 1.20443661477065 0.506142894557122 0.612756340057424 NA Hypothetical protein VI - Unknowns Rv1375 - 56.2 28.2 35.5 57.8 52.6 57.3 101.279543522802 0.277906715315007 0.275505020414061 1.00871742699039 0.313110171591128 0.846061021823653 hypothetical protein V - Conserved hypotheticals Rv1376 - 21.5 14.6 14.5 30.4 10.9 11 40.334364193459 -0.127895880603629 0.423446106175402 -0.302035793312153 0.762624777262925 0.959593750764785 hypothetical protein V - Conserved hypotheticals Rv1377c - 53.6 25.1 19.7 43.6 39.5 44.4 36.8153954414157 0.188962024542492 0.383133790962332 0.493201145395892 0.621870468648837 0.931582271037618 Putative transferase IV.H - Miscellaneous transferases Rv1378c - 135 102.4 71.7 189.7 236.8 232.2 367.348029428367 0.925202043272939 0.224676622133797 4.11792751059775 3.82294898615024e-05 0.00332971033355129 hypothetical protein V - Conserved hypotheticals Rv1379 pyrR 67.7 37.5 27.7 83.4 42.2 26.6 42.5439943277426 0.0899693345560658 0.393185319495873 0.228821703392744 0.819007497411167 0.967203057682185 Probable pyrimidine operon regulatory protein PyrR I.J.1 - Repressors/activators Rv1380 pyrB 11.7 5.9 5.9 13.9 11.1 17.7 16.4010985463671 0.692362612711776 0.547223072074422 1.26522920549961 0.205789175954717 NA Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1381 pyrC 26.4 14 10.9 28.6 21.8 12.3 37.329226359059 0.175133537364017 0.384916294670015 0.454991227415189 0.649115550059913 0.939577115195416 Probable dihydroorotase PyrC (DHOase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1382 - 22.1 12 10.9 19.9 17.8 13.7 12.2349178421886 0.0751114544992052 0.601457006058101 0.124882499900499 0.900616572957899 NA Probable export or membrane protein VI - Unknowns Rv1383 carA 25.7 8.5 8.8 18.3 15.6 14.1 25.7760649471074 -0.0143622452757346 0.451713886160996 -0.0317950050147799 0.974635530044946 NA Probable carbamoyl-phosphate synthase small chain CarA (carbamoyl-phosphate synthetase glutamine chain) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1384 carB 55.2 21.6 33.1 43.4 46.7 31.5 206.120275977712 -0.0458782481359647 0.251454231253462 -0.182451684774873 0.855228267835753 0.975712312098852 Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1385 pyrF 27.4 8.9 8.9 34.7 40.8 21.2 29.1139967842798 0.927096664841313 0.439794451688184 2.10802264849541 0.035029030408892 0.39160811058244 Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1386 PE15 767.4 518.6 243.3 708.4 699.7 627.5 287.057851056222 0.299332516648606 0.23043529536458 1.29898727612461 0.193948295825916 0.746120982273274 PE family protein PE15 IV.C.1.a - PE subfamily Rv1387 PPE20 579.2 518.3 326.8 713.7 778.4 683.8 1563.01580545113 0.417123694665299 0.195591244922994 2.13262968303885 0.0329551163453305 0.383117660251623 PPE family protein PPE20 IV.C.2 - PPE family Rv1388 mihF 276.1 217.5 130.2 338.4 326.6 220.7 227.209138596352 0.33622438382173 0.219100858850019 1.53456442656798 0.124890856397006 0.669473079058369 Putative integration host factor MihF II.A.4 - Nucleoproteins Rv1389 gmk 349.8 133.8 91.1 249.7 201.8 119.9 180.737961932383 -0.0851456074351283 0.278410967810554 -0.305827058842976 0.75973632495698 0.959593750764785 Probable guanylate kinase Gmk I.F.1 - Purine ribonucleotide biosynthesis Rv1390 rpoZ 1014.8 562.4 534.2 524 669 694.7 360.299614495417 -0.326071785593986 0.229200845340158 -1.42264652257308 0.154838650377301 0.705807023060417 Probable DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit) VI - Unknowns Rv1391 dfp 395.6 181.5 220.1 301.1 316.6 224.1 547.383009933465 -0.10163156419326 0.203120789837291 -0.500350379075777 0.616828386418887 0.931582271037618 Probable DNA/pantothenate metabolism flavoprotein homolog Dfp I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1392 metK 436.2 239.9 246 303 366.9 266.4 603.910562991328 -0.161082044588622 0.193828176514651 -0.831055873739008 0.405942065920015 0.898987793702772 Probable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase) I.D.2 - Aspartate family Rv1393c - 47.5 32.6 28.1 24.9 25.2 22.9 72.4466906219736 -0.792466842248326 0.296489158972083 -2.67283581293758 0.00752130525744934 0.173743285221869 Probable monoxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1394c cyp132 35.2 31.9 20.4 14.7 15.2 24.4 54.3085002900076 -0.954342654324787 0.367241242287545 -2.59868049781171 0.00935828311034603 0.196098568812251 Probable cytochrome P450 132 Cyp132 IV.F - Cytochrome P450 enzymes Rv1395 - 17.1 12.9 4.1 23.3 8.8 10.4 19.5687846074218 0.290189258471966 0.543065852054952 0.534353720407745 0.593096831620202 NA Transcriptional regulatory protein I.J.1 - Repressors/activators Rv1396c PE_PGRS25 344.9 181.3 182.9 271.2 198.8 155.3 614.584540943975 -0.360437836090282 0.195153852377013 -1.84694194708471 0.0647555544210861 0.514454587842348 PE-PGRS family protein PE_PGRS25 IV.C.1.b - PE_PGRS subfamily Rv1397c vapC10 1949.7 1153.1 1017.9 1437.8 1533.5 1034.4 870.885627627053 -0.221570938458212 0.173345690547006 -1.27820275057907 0.201177946557759 0.760188798058419 Possible toxin VapC10 V - Conserved hypotheticals Rv1398c vapB10 10706 4571.7 2783.5 5648.4 5665.2 3855.6 2187.5432494843 -0.316012560353079 0.219133980483461 -1.44209747687639 0.149274876759225 0.695223866622759 Possible antitoxin VapB10 V - Conserved hypotheticals Rv1399c nlhH 29.1 13.1 11.6 33.3 26.7 27.2 34.7849742402415 0.530872225424533 0.387078905508818 1.3714832244002 0.170224369483808 0.726605873444774 Probable non lipolytic carboxylesterase NlhH II.B.5 - Esterases and lipases Rv1400c lipI 64.6 7.7 17.9 65.7 45.3 37.8 56.4645262985327 0.63992564276325 0.423486249905954 1.51108954046409 0.130765639227865 0.676070575895843 Probable lipase LipH II.B.5 - Esterases and lipases Rv1401 - 33.3 36.9 8.8 45.6 31.8 19.9 27.2134703230373 0.233111636637307 0.476171884075791 0.489553550793442 0.624449851886147 0.932628666477906 Possible membrane protein II.C.5 - Other membrane proteins Rv1402 priA 25.4 15.2 16 37.6 20.9 13.5 65.9144391791985 0.177420776431012 0.340640192949261 0.520845103142128 0.602474680334405 0.931398768888358 Putative primosomal protein N' PriA (replication factor Y) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1403c - 11.5 6.2 8.8 4.7 6.5 9.4 9.95915119842792 -0.805133921376764 0.712431982907964 -1.13012040544617 0.258425492555767 NA Putative methyltransferase IV.H - Miscellaneous transferases Rv1404 - 581.9 363.5 390.2 366.9 427.1 385.3 332.521857293738 -0.391903044467126 0.222237154940364 -1.76344520146639 0.0778254318549808 0.550550241715797 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1405c - 49.5 1.8 20.4 9.3 8.7 3.2 18.9141323722514 -1.90737784023092 0.705575809075637 -2.70329256714419 0.00686562860020888 NA Putative methyltransferase IV.H - Miscellaneous transferases Rv1406 fmt 27.8 12.3 16 25 30.5 13.5 30.2104670180151 0.0837238606607186 0.419446039229297 0.199605796289209 0.841788894229552 0.974476040705366 Probable methionyl-tRNA formyltransferase Fmt II.A.3 - Aminoacyl tRNA synthases and their modification Rv1407 fmu 27.4 15.2 6.7 26 11.4 19.4 36.9969428247283 0.100077292730112 0.420860084723773 0.237792312368604 0.812042181515246 0.966073477417693 Probable Fmu protein (sun protein) II.A.4 - Nucleoproteins Rv1408 rpe 181.3 176.6 127.2 145.2 196.4 160.4 189.629915220147 -0.178011642126026 0.261717458615794 -0.680167242443502 0.496398571385923 0.913636152872564 Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase) I.B.5 - Pentose phosphate pathway Rv1409 ribG 106.4 62.1 46.5 96.8 94.3 75 128.552556444675 0.151115205536341 0.238278830601579 0.634194842885635 0.52595367276111 0.921428654655606 Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase) I.G.9 - Riboflavin Rv1410c - 462 248 213.3 372.9 314.5 294 784.322287956137 -0.0632223887728572 0.172376837976735 -0.366768467938774 0.713791729920522 0.949890877982223 Aminoglycosides/tetracycline-transport integral membrane protein III.A.6 - Efflux proteins Rv1411c lprG 849.1 602.4 451.1 639 803.5 656.5 764.450116105597 -0.0353377129057697 0.192524202748381 -0.183549457165935 0.854366916651474 0.975712312098852 Conserved lipoprotein LprG II.C.1 - Lipoproteins(lppA-lpr0) Rv1412 ribC 41.7 29.7 22.7 43.8 22.1 16.8 28.2268207156457 -0.284442470137324 0.442221712682094 -0.643212357014693 0.520086316225706 0.916279459032039 Probable riboflavin synthase alpha chain RibC (RibE) I.G.9 - Riboflavin Rv1413 - 23.4 13.3 12.3 22.3 25.7 9.9 13.9691387122277 0.148743109321281 0.572854416458771 0.259652548793759 0.795131798000912 NA hypothetical protein VI - Unknowns Rv1414 - 11.2 0 9.4 10.3 16.8 20.8 6.70002529658887 0.840200819493436 0.867346674418131 0.968702416547679 0.332693686513037 NA hypothetical protein VI - Unknowns Rv1415 ribA2 407.6 242.7 185.7 290.5 259.1 223.1 545.350362185286 -0.270233872458844 0.174864409915546 -1.54539092654336 0.122251733690775 0.665646250765128 Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) I.G.9 - Riboflavin Rv1416 ribH 353.5 208.7 209.8 379.6 209.4 202.9 201.046079539555 -0.149805308403305 0.249994889810111 -0.599233482400752 0.54901719798487 0.92521033104044 Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase) I.G.9 - Riboflavin Rv1417 - 195.1 88.3 82.1 141.2 97.4 60.7 79.6332981497686 -0.420627783569085 0.307925433246194 -1.36600533166347 0.171937289935124 0.729574936755292 Possible conserved membrane protein VI - Unknowns Rv1418 lprH 90.2 42.4 39.3 82.9 83 33.8 65.3825027440911 0.0568146587413033 0.324798723772049 0.174922666202276 0.861140399802139 0.976194404037999 Probable lipoprotein LprH II.C.1 - Lipoproteins(lppA-lpr0) Rv1419 - 218 131.9 137.8 181 194.9 185.3 133.844444645911 -0.00730826326766436 0.25198477366029 -0.0290027971194676 0.976862359755297 0.998153412295216 hypothetical protein VI - Unknowns Rv1420 uvrC 94.1 45.1 57.6 84.3 74.5 51.1 209.748276279733 -0.0995678621161122 0.235704474513874 -0.422426694790011 0.67271359648898 0.940710721884994 Probable excinuclease ABC (subunit C-nuclease) UvrC II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1421 - 86.5 50.2 32 78.9 76.6 54.7 88.7072621717739 0.180414734721092 0.273382785138042 0.65993451134823 0.509295856126709 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv1422 - 83 22.2 30.8 88.8 42.6 23.9 74.8193603174475 0.0739243102633462 0.385882073444385 0.191572284256425 0.84807725432869 0.975474031954732 hypothetical protein V - Conserved hypotheticals Rv1423 whiA 70.1 22.7 46.1 83.5 38 46.2 78.8801233696649 0.0718330380116353 0.357689263870429 0.200825256073821 0.840835213739199 0.974340260244082 Probable transcriptional regulatory protein WhiA I.J.1 - Repressors/activators Rv1424c - 34.6 22.3 15.6 36.8 23.9 26.3 31.2829100711434 0.10778629581204 0.403460446911769 0.267154554150412 0.789350165309964 0.963989543249515 Possible membrane protein II.C.5 - Other membrane proteins Rv1425 - 124.1 62.2 58.1 78.4 83.5 84.3 179.779852013059 -0.15125640537246 0.233801705219442 -0.646943123149994 0.517668754999834 0.915911629458156 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv1426c lipO 43.9 15.8 20.8 42.1 25.3 15 52.581466358249 -0.0979137837339004 0.370483170168052 -0.264286725060916 0.791558988605886 0.964516371138273 Probable esterase LipO II.B.5 - Esterases and lipases Rv1427c fadD12 56.3 38.9 38.3 46.3 50.6 29.6 112.951244964353 -0.280643628091624 0.265864590649115 -1.05558858893704 0.291156216508912 0.832752355381209 Possible long-chain-fatty-acid--CoA ligase FadD12 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1428c - 27.6 19.8 14.3 19.9 35.3 29.4 31.8443106868879 0.253307534797873 0.426007018607364 0.594608829746388 0.55210497650502 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv1429 - 14.9 8.2 9.5 15.6 19.9 11.7 26.0446397247289 0.302361421286088 0.437333556769998 0.691374847883228 0.489330006190155 NA hypothetical protein V - Conserved hypotheticals Rv1430 PE16 6 3.8 3.7 7.2 6.5 7.1 13.8335595385719 0.428870231042396 0.57222214610158 0.749482056862342 0.45356670946908 NA PE family protein PE16 IV.C.1.a - PE subfamily Rv1431 - 19.6 17.5 13.8 18.3 16.4 1.6 40.8153410628323 -0.661168501225946 0.454851585245494 -1.45359172678072 0.146059531993528 0.693983707603282 hypothetical protein II.C.5 - Other membrane proteins Rv1432 - 7.1 2.4 1.5 9.8 5.9 5.4 10.6837663480506 0.792036283669717 0.679500800533649 1.16561493827187 0.243770165360517 NA Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1433 - 21.2 8.5 9.5 16.7 16.2 12.1 17.2921837040285 0.0157190970394645 0.521925536385383 0.0301175090000918 0.975973336902135 NA Possible conserved exported protein II.C.5 - Other membrane proteins Rv1434 - 29.1 19.2 29.6 37.6 3.6 53.9 6.15874475725513 -0.00957191207220136 0.933308677003337 -0.0102558910123227 0.991817126354518 NA Hypothetical protein VI - Unknowns Rv1435c - 467.4 196.7 130.2 371.4 350.8 272.7 277.34197154256 0.236909820234215 0.236920317060366 0.999955694698195 0.317331949509848 0.847340730510678 Probable conserved proline, glycine, valine-rich secreted protein V - Conserved hypotheticals Rv1436 gap 690.5 417.3 437.9 524.8 658.7 517.4 895.26852885934 -0.0602260225819157 0.199375641908202 -0.302073121899441 0.762596321530031 0.959593750764785 Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) I.B.1 - Glycolysis Rv1437 pgk 370.3 247.6 192.3 304.8 270.1 242.7 540.268677808497 -0.161344032550541 0.177480824310193 -0.909078674711082 0.363308598379337 0.882928450686174 Probable phosphoglycerate kinase Pgk I.B.1 - Glycolysis Rv1438 tpi 233.1 137.1 116.6 188.3 154.1 150.4 204.851144743348 -0.152542905205994 0.212864430884823 -0.716619984710047 0.473608609853378 0.904373078832156 Probable triosephosphate isomerase Tpi (TIM) I.B.1 - Glycolysis Rv1439c - 40.9 25.9 14.2 34.2 13 46.5 19.2057191105168 0.0424209907862809 0.540358713954269 0.0785052404834005 0.937426161787539 NA hypothetical protein VI - Unknowns Rv1440 secG 369.2 268.6 131.1 394.4 224.9 237.1 98.683427891274 0.0363613206440548 0.294702842822121 0.123382999281083 0.901803818813444 0.989837048745233 Probable protein-export membrane protein (translocase subunit) SecG III.D - Protein and peptide secretion Rv1441c PE_PGRS26 15.2 3.6 6 15.6 16.1 7.7 23.2458614027308 0.488512909797645 0.48918122717254 0.998633804124581 0.317972118310615 NA PE-PGRS family protein PE_PGRS26 IV.C.1.b - PE_PGRS subfamily Rv1442 bisC 114.8 55.4 60.1 88 79.5 56.3 276.855836831003 -0.213165155498493 0.21103235359516 -1.01010651621421 0.312444260635481 0.846061021823653 Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase) I.G.1 - Biotin Rv1443c - 78.5 35.3 30.1 87.5 55.3 23.9 37.5180201263668 0.106350753098676 0.41920989456832 0.253693327558956 0.799732489296259 0.965592404376002 hypothetical protein VI - Unknowns Rv1444c - 97.7 76.1 39.6 98.2 67.4 81.9 49.7197170008862 0.0633168387611927 0.343932584346659 0.184096656271957 0.853937629558375 0.975712312098852 hypothetical protein VI - Unknowns Rv1445c devB 110.9 45.8 49.6 101.7 74.6 68.4 86.6377841014121 0.0926392380898554 0.286386069044692 0.323476761278491 0.746334204136585 0.956095160416489 Probable 6-phosphogluconolactonase DevB (6PGL) I.B.5 - Pentose phosphate pathway Rv1446c opcA 129 73.4 51.4 82.8 76.3 78.7 117.940819231516 -0.246040103027105 0.253664011053267 -0.969944857394214 0.332073978986536 0.853347384539607 Putative OXPP cycle protein OpcA I.B.5 - Pentose phosphate pathway Rv1447c zwf2 240.6 177.7 159.1 165.4 167.1 149.4 448.649709865887 -0.477954076230898 0.201200491633511 -2.37551147291179 0.0175246475896231 0.276757764055105 Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) I.B.5 - Pentose phosphate pathway Rv1448c tal 365 209.7 201.4 278.7 229.9 245.8 461.748301232332 -0.217804603092363 0.194230197478696 -1.12137353470103 0.262128896517713 0.806685286411718 Probable transaldolase Tal I.B.5 - Pentose phosphate pathway Rv1449c tkt 223.6 141.6 107 164.4 161.9 123.3 515.564414111624 -0.237063452263598 0.176424646394214 -1.34370938022961 0.179042382854925 0.734764437650925 Transketolase Tkt (TK) I.B.5 - Pentose phosphate pathway Rv1450c PE_PGRS27 3.6 2.6 3.6 4.9 1.8 1.4 19.327843883624 -0.473573731821792 0.565738012680224 -0.837090174616699 0.402541882816929 NA PE-PGRS family protein PE_PGRS27 IV.C.1.b - PE_PGRS subfamily Rv1451 ctaB 278.6 171 137.5 176.6 129.8 114.5 250.291360728009 -0.644503459851059 0.209404320375481 -3.07779447289055 0.00208538687423072 0.0776385081881511 Probable cytochrome C oxidase assembly factor CtaB I.B.6.a - aerobic Rv1452c PE_PGRS28 2.6 0 1.5 4.8 0.4 0.6 4.82685080531104 0.011925628934934 2.6161617533252 0.00455844479790909 0.996362899870618 NA PE-PGRS family protein PE_PGRS28 IV.C.1.b - PE_PGRS subfamily Rv1453 - 2.9 0 2.7 1.8 4 0 3.61231591102243 -0.282221697669447 1.17601624031388 -0.239981122704668 0.810344890944197 NA Possible transcriptional activator protein V - Conserved hypotheticals Rv1454c qor 38.2 28.1 19.7 34.9 17.7 18.7 40.6217565040558 -0.422607232288308 0.38409976288565 -1.10025382237511 0.271221545817354 0.812783093966197 Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1455 - 3.3 2 1.4 6.7 8 6 5.52181187551104 1.73901565957365 0.919594665732706 1.8910675805063 0.0586153235115556 NA hypothetical protein V - Conserved hypotheticals Rv1456c - 19.8 8.2 1.9 18.7 16.9 15.2 18.1366461798673 0.701767276547996 0.579534094628342 1.21091629129783 0.225927488196192 NA Probable unidentified antibiotic-transport integral membrane ABC transporter II.C.5 - Other membrane proteins Rv1457c - 35.1 20.4 17.8 55.8 28.4 38.5 39.6531958694933 0.599944622485903 0.380537332925437 1.57657231124668 0.114893968016475 0.651222777732727 Probable unidentified antibiotic-transport integral membrane ABC transporter II.C.5 - Other membrane proteins Rv1458c - 63.1 40.8 29.3 75.1 52.2 40.9 73.7097360055839 0.194688774978781 0.296485476967906 0.656655351114738 0.511402549609273 0.915911629458156 Probable unidentified antibiotic-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1459c - 46.6 42.7 21.7 37.4 46.5 32 107.406854820795 -0.110863946614489 0.2798734788288 -0.396121658538088 0.692015281203659 0.942913432418385 Possible conserved integral membrane protein V - Conserved hypotheticals Rv1460 - 70.2 40.4 39 82.9 102.3 55.6 81.8871408124667 0.506126940943393 0.287256190527112 1.76193571325532 0.0780801597666552 0.550943168149409 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1461 - 132 100.1 91 103.9 163.5 108 481.96449178126 -0.00491033459455249 0.232398244940478 -0.0211289659085426 0.983142778595725 0.998667985896356 hypothetical protein V - Conserved hypotheticals Rv1462 - 70.4 35.7 33.3 60 47.5 41.2 89.8802096873164 -0.0714417704213955 0.270817745335935 -0.263800181678552 0.791933894571281 0.964548283744677 hypothetical protein V - Conserved hypotheticals Rv1463 - 82.2 36.2 40.3 59 68.9 41 68.5515091592578 -0.0987221118342481 0.304740529977734 -0.323954650342904 0.74597236804179 0.956095160416489 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1464 csd 68.9 38.9 39 65.3 66.1 37.8 104.207772637629 0.0102924969408232 0.265365067484523 0.0387861787475983 0.969060864305043 0.998153412295216 Probable cysteine desulfurase Csd IV.H - Miscellaneous transferases Rv1465 - 86.3 52.3 37.8 83 71.4 51.3 48.0453025584137 0.0756494590431853 0.336565658737279 0.224768799428336 0.822159139476313 0.967698799911269 Possible nitrogen fixation related protein V - Conserved hypotheticals Rv1466 - 170.5 56.6 96.3 153.5 91.5 89.6 60.0145566147132 -0.136300525969298 0.349864978486202 -0.389580364856877 0.696846873771202 0.944379447746764 hypothetical protein V - Conserved hypotheticals Rv1467c fadE15 42.7 23.1 16.7 33.3 43.7 25.2 87.4632102150432 0.162106449371471 0.284578653827274 0.569636714459484 0.568924121518986 0.92521033104044 Probable acyl-CoA dehydrogenase FadE15 I.A.3 - Fatty acids Rv1468c PE_PGRS29 37.7 7 10.2 49.2 18.8 27.8 41.0795647929705 0.720845891284657 0.460851758900768 1.56416000885845 0.117779996208703 0.656813446599338 PE-PGRS family protein PE_PGRS29 IV.C.1.b - PE_PGRS subfamily Rv1469 ctpD 12.7 7.9 4.3 18.3 15.5 5.7 31.597019334753 0.531831968562749 0.431024526483763 1.23387866788315 0.217248119612482 0.773070552038584 Probable cation transporter P-type ATPase D CtpD III.A.2 - Cations Rv1470 trxA 25.9 23 8.4 35.9 27.2 33.7 14.5318289324517 0.667439027590573 0.575740909139539 1.15926976352623 0.246346242539345 NA Probable thioredoxin TrxA I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv1471 trxB1 37.5 13.3 17.9 31 53.4 38.3 17.7859794555518 0.601963223325402 0.53865628635107 1.11752751908491 0.263768839984581 NA Probable thioredoxin TrxB1 I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv1472 echA12 116.5 57.9 80.3 91.1 102.4 65.2 118.321802755481 -0.20442626920988 0.274337285879491 -0.745163999689344 0.456172583195736 0.901158530199572 Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1473 - 51.8 21.2 30.4 55.6 44.3 31.6 100.41611447054 0.161853646920928 0.284720555104232 0.568464917686309 0.5697193207962 0.92521033104044 Probable macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1473A - 15.2 15.6 23 20.9 13.1 0.1 4.2232380438977 -0.598579049563507 1.06866703507071 -0.560117445303157 0.575399331880449 NA Possible transcriptional regulatory protein ? Rv1474c - 158.4 72.3 78.6 118.6 100 80 89.7453411801391 -0.220716847133202 0.2758200878416 -0.800220349650373 0.423583141554971 0.901158530199572 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1475c acn 543.7 311.2 342.3 236.7 312 266.3 1566.40374728411 -0.741910405220429 0.207329912081327 -3.57840505391913 0.000345697406965712 0.0203446601631311 Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase) I.B.3 - TCA cycle Rv1476 - 121.8 76.8 60.7 78.7 74.8 129 81.6776682542948 -0.0646424541089663 0.32439827691089 -0.199268796137049 0.842052486744601 0.974476040705366 Possible membrane protein VI - Unknowns Rv1477 ripA 241.6 131.3 111.9 197.5 210 165.9 395.7756620198 0.0829462454188531 0.187518283337254 0.442336842800939 0.658245474102168 0.939577115195416 Peptidoglycan hydrolase IV.A - Virulence Rv1478 - 160.2 63.9 52.3 144.2 107 138 124.865757814881 0.38614098575768 0.278984124918005 1.38409662510786 0.16632887018476 0.725041090026968 Possible invasion protein IV.A - Virulence Rv1479 moxR1 433.3 231.7 227.5 385.9 311.3 305.5 571.204724062468 -0.00162863145420694 0.185520701776234 -0.00877870468693739 0.992995697031761 0.999833281786427 Probable transcriptional regulatory protein MoxR1 I.J.1 - Repressors/activators Rv1480 - 300.3 124.8 123.2 289.5 178 108.1 275.067060050572 -0.0732691651657008 0.262535257280828 -0.279083144582468 0.78018101810309 0.963989543249515 hypothetical protein V - Conserved hypotheticals Rv1481 - 277.7 128.4 158.8 194.8 201.4 142.4 296.676965999102 -0.25472783948212 0.218136673503422 -1.16774421921367 0.242909954357457 0.78958848015113 Probable membrane protein II.C.5 - Other membrane proteins Rv1482c - 1.5 0 0 0 0 1.7 0.224003920381287 -1.3705150752187 4.01877258136825 -0.341028273551147 0.733082297003807 NA hypothetical protein V - Conserved hypotheticals Rv1483 fabG1 210.9 194 132 236.7 242.4 260.2 256.806468037288 0.260677214467359 0.237634008675518 1.09696930973927 0.272654808346146 0.813286748879977 3-oxoacyl-[acyl-carrier protein] reductase FabG1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein) I.H.1 - Synthesis of fatty and mycolic acids Rv1484 inhA 235.4 100.3 74.9 319.1 205.9 147.3 221.322546709466 0.600695870079453 0.258889382260513 2.32028005488069 0.0203257323536418 0.297465479842186 NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv1485 hemZ 52.2 39.9 41.6 52.6 56.6 50 82.3920189091107 0.0172491301319362 0.300682966995791 0.0573665023472303 0.954253246295766 0.998153412295216 Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase) I.G.12 - Heme and porphyrin Rv1486c - 216.5 142.5 106.2 206 167.6 132.1 222.807060620504 -0.0434693741556123 0.210080109624553 -0.206918085835442 0.836073831718214 0.970813891745226 hypothetical protein V - Conserved hypotheticals Rv1487 - 265.4 183.8 221.7 349.4 245.6 175.7 169.660380415976 -0.0367853645697954 0.270468795244868 -0.136005946772869 0.891816579806309 0.985189043752372 hypothetical protein V - Conserved hypotheticals Rv1488 - 289.7 205 164.5 234.6 247.8 218.3 420.471219343917 -0.101355906590076 0.193673923496813 -0.523332747951192 0.600742715615551 0.931398768888358 Possible exported conserved protein V - Conserved hypotheticals Rv1489 - 398.9 252.8 174 260.5 307.8 143.9 144.50003955598 -0.367975822820146 0.252253100574965 -1.45875639182001 0.14463216897981 0.690135194188255 hypothetical protein ? Rv1489A - 245.1 108.6 125 161.6 158.7 151.5 57.8457518820071 -0.213808126043851 0.321050739793447 -0.665963661013235 0.50543432783208 0.915911629458156 hypothetical protein ? Rv1490 - 10.7 9.7 3.6 8.2 14.3 13 20.2800546022406 0.385145307108859 0.521518890766039 0.738506914952081 0.460206466680124 NA Probable membrane protein II.C.5 - Other membrane proteins Rv1491c - 151.3 66.2 98.1 67.1 87.3 35.5 103.267367306547 -0.952530478656451 0.310338306024842 -3.06932937431257 0.00214539916322556 0.0776385081881511 hypothetical protein II.C.5 - Other membrane proteins Rv1492 mutA 93.5 41.2 31.3 58.7 50.5 37.6 148.667356617586 -0.297534851478466 0.251121065914081 -1.18482633225309 0.236086119008373 0.78958848015113 Probable methylmalonyl-CoA mutase small subunit MutA (MCM) I.A.3 - Fatty acids Rv1493 mutB 97.9 44.4 57.3 48.6 55.6 47.1 213.479481123956 -0.59103911168916 0.240865076386024 -2.45381821456726 0.0141348416307627 0.262395784903958 Probable methylmalonyl-CoA mutase large subunit MutB (MCM) I.A.3 - Fatty acids Rv1494 mazE4 131.9 63.8 72.3 71.8 96.5 35.1 37.5259801812333 -0.58408241872287 0.39410902355063 -1.48203259458695 0.13833162236325 0.682181933169668 Possible antitoxin MazE4 VI - Unknowns Rv1495 mazF4 48.7 26 25.9 24.2 28 30.3 15.2169454221398 -0.55425030226273 0.557050514860133 -0.994973144225339 0.319749326130576 NA Possible toxin MazF4 V - Conserved hypotheticals Rv1496 - 47.2 22.3 25.6 42.2 42.5 35.5 56.9648872797804 0.146746977315725 0.319906097358941 0.458718913228689 0.64643603045287 0.939577115195416 Possible transport system kinase V - Conserved hypotheticals Rv1497 lipL 123.6 86.5 65.7 148.9 109.4 89.4 212.049421905209 0.161428495830787 0.220165518479619 0.733214251466588 0.463427764496166 0.901158530199572 Probable esterase LipL II.B.5 - Esterases and lipases Rv1498c - 80.2 43.4 34.5 57 70.2 83.9 60.1641123180606 0.23592365542476 0.336137657668159 0.701866185007059 0.482762618801948 0.907435018449577 Probable methyltransferase IV.H - Miscellaneous transferases Rv1498A - 47.3 20.9 20 37.4 23.2 57.4 11.2516967867083 0.223222290969926 0.659996225174752 0.338217526790886 0.735199268860288 NA hypothetical protein ? Rv1499 - 11.2 4.1 3.6 3.3 17.9 7.7 4.0430605822851 0.225523360702181 1.1044999469785 0.204185940722885 0.83820819759758 NA Hypothetical protein VI - Unknowns Rv1500 - 34.1 15.8 14.1 16.6 31.6 54.4 45.8710985220632 0.542081906636139 0.455189128537902 1.19089379040607 0.233695282574994 0.78958848015113 Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1501 - 88.3 40.6 41.9 46.5 86.2 109.7 90.9587658707899 0.345531196105124 0.357477478050507 0.966581721426111 0.333753175782829 0.853347384539607 hypothetical protein V - Conserved hypotheticals Rv1502 - 499.9 427.8 322 468.2 445 459.1 643.860639661335 -0.0716977523788611 0.205254953323699 -0.349310704652226 0.726856062864191 0.949890877982223 Hypothetical protein VI - Unknowns Rv1503c - 39.6 42.4 22.5 26 47.6 59.6 35.5298902801466 0.128929164496108 0.451768782417742 0.285387502443429 0.77534728120929 0.963013023606306 hypothetical protein V - Conserved hypotheticals Rv1504c - 41.9 39 27.3 47.3 97.9 80.5 53.4740526244231 0.871636224568181 0.387783387292075 2.24773998353795 0.0245927748384182 0.327036611553196 hypothetical protein V - Conserved hypotheticals Rv1505c - 124.7 118.4 79.5 64.6 156.2 177.5 132.473786310153 0.102333624700343 0.362959963024065 0.281941908544768 0.777988054121036 0.963013023606306 hypothetical protein V - Conserved hypotheticals Rv1506c - 66 53.9 38.1 32.6 94.7 82.3 49.7579108437947 0.185406450818979 0.425486221446968 0.435751950294559 0.663016709234107 0.939577115195416 Hypothetical protein VI - Unknowns Rv1507c - 122.8 104.8 91.9 63.3 142.4 176.9 136.037811898488 0.0473672107016318 0.362755636416812 0.130576084687506 0.896110662375535 0.987900395428749 hypothetical protein VI - Unknowns Rv1507A - 10.5 0 7.9 6.4 5.2 13.7 5.82387881499945 0.0457473447707929 0.955483048315176 0.0478787612731175 0.961812866023749 NA Hypothetical protein ? Rv1508c - 75.7 42.4 34 50.8 60.3 63.2 156.171679096599 0.0330151188792699 0.250637805737065 0.131724417161172 0.895202271700101 0.987686271847818 Probable membrane protein II.C.5 - Other membrane proteins Rv1508A - 72.1 50.9 28 36.6 21 46.7 24.3577935981407 -0.704578329800716 0.481418701215198 -1.46354582408664 0.143318084340226 NA hypothetical protein ? Rv1509 - 77.5 108.8 57.4 58.2 78.7 72.3 111.298260514919 -0.463779026820252 0.32756669040803 -1.41583085338302 0.156825033855589 0.70782226167295 Hypothetical protein VI - Unknowns Rv1510 - 27.3 8.2 13.5 22.5 10.5 20.1 34.6621618651608 -0.0597282232060078 0.430793235551486 -0.138647077708975 0.889729039915307 0.984396209762296 Conserved probable membrane protein II.C.5 - Other membrane proteins Rv1511 gmdA 119.5 79.6 51.6 85.4 93.5 66.2 133.721114255484 -0.196427896904393 0.241207741573935 -0.814351544534417 0.415443589031314 0.901158530199572 GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD) I.C.3 - Sugar nucleotides Rv1512 epiA 100.5 47.1 44.2 77.2 69.9 64.3 102.256053155042 -0.0242064658812964 0.261334487710161 -0.0926263735544278 0.926200390749604 0.996131826654618 Probable nucleotide-sugar epimerase EpiA I.C.3 - Sugar nucleotides Rv1513 - 141.1 111.5 88.1 102 169.7 106.4 141.791458850796 -0.0647146206137966 0.274400348337268 -0.235840154744466 0.813556707892842 0.966389401486634 hypothetical protein V - Conserved hypotheticals Rv1514c - 15.7 12.8 6.3 22.4 12.3 7.8 14.8627375077118 0.209416046605733 0.582208639035894 0.359692441102411 0.719077145360918 NA hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1515c - 12.4 5.3 9.2 13.1 17.8 19.3 18.0532853651831 0.677867112678303 0.537316000037269 1.26157998762606 0.20709996103321 NA hypothetical protein V - Conserved hypotheticals Rv1516c - 11.6 7.8 8.2 10.6 5.3 1.5 11.2117981407474 -0.843984071283802 0.712241133310612 -1.18496957253905 0.236029477583235 NA Probable sugar transferase IV.H - Miscellaneous transferases Rv1517 - 5.9 9.1 9.1 6.1 8.4 1.9 7.87252418132958 -0.911160064329593 0.832039221513873 -1.09509268405853 0.273476033484405 NA hypothetical protein V - Conserved hypotheticals Rv1518 - 7.2 5.3 2.5 6.2 8.4 4.2 7.61708216075457 0.236863226195 0.760337268570954 0.311523893390339 0.755402381627678 NA hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1519 - 2.8 18.3 4.3 2 13.2 0 2.6131885716682 -0.814574429479787 1.48439874020746 -0.54875715494473 0.583172116925544 NA hypothetical protein V - Conserved hypotheticals Rv1520 - 27.8 18.3 11.4 16.8 17.6 12.1 28.0644941317169 -0.478728266036826 0.421862555564725 -1.1347967714176 0.256460479314342 0.801061876847584 Probable sugar transferase IV.H - Miscellaneous transferases Rv1521 fadD25 251 143.9 147.9 164.8 199.4 179.5 514.74899860987 -0.179966322309426 0.20737481509845 -0.867831140555752 0.385486779745272 0.893826103932853 Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1522c mmpL12 38.2 31.2 21.2 33.7 35.3 38.7 184.261673819625 0.0631649934683692 0.243666284085018 0.259227466391412 0.795459740117689 0.965360560531176 Probable conserved transmembrane transport protein MmpL12 II.C.4 - Conserved membrane proteins Rv1523 - 22 22.8 4.7 15.9 12.9 2.7 21.4512830100852 -0.731406788874431 0.57992585248063 -1.26120742116573 0.207234125585796 NA Probable methyltransferase IV.H - Miscellaneous transferases Rv1524 - 21.7 10.1 8.3 26.7 26.2 19.3 35.7425037151844 0.681131827644702 0.381579352260931 1.78503324042264 0.0742559253299491 0.54162997700187 Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1525 wbbL2 47.1 44.4 20.5 48.5 48.1 18 46.4211009330144 -0.0947962871143367 0.376509331205089 -0.251776727049296 0.801213647061704 0.965592404376002 Possible rhamnosyl transferase WbbL2 I.C.3 - Sugar nucleotides Rv1526c - 16.5 14.8 4.2 9.3 10.1 17.4 24.3656029780681 -0.129482181106424 0.51253156742213 -0.25263259735918 0.800552137868828 NA Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1527c pks5 16.2 11.7 5.7 20 14.8 13.4 133.825431259924 0.391561793151241 0.259473550179603 1.50906245696414 0.131282822573353 0.677478147831891 Probable polyketide synthase Pks5 I.I - Polyketide and non-ribosomal peptide synthesis Rv1528c papA4 3 3.5 1.6 1.1 3.7 0 1.20683109739516 -1.14168281432154 1.84047973899969 -0.620318056281377 0.535048409533349 NA Probable conserved polyketide synthase associated protein PapA4 I.I - Polyketide and non-ribosomal peptide synthesis Rv1529 fadD24 15.1 9.8 11.8 16.7 16.5 13.3 38.9429962027559 0.122782111522344 0.378682381478091 0.324235078070163 0.745760066859246 0.956095160416489 Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1530 adh 15.2 4.3 6 11.9 16 5.6 15.6305900895408 0.18899050341345 0.573385799021125 0.329604436901108 0.741698869632287 NA Probable alcohol dehydrogenase Adh I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1531 - 40.2 14.9 16.4 57.6 33.6 69.3 34.2440131593563 1.00072832953743 0.431709132989583 2.31806152120849 0.0204459777617277 0.297479746745841 hypothetical protein V - Conserved hypotheticals Rv1532c - 31.1 15.7 22.2 27.3 54.4 32.1 20.8382794973899 0.468018624291674 0.512358716731428 0.91345888926684 0.361001245739903 NA hypothetical protein V - Conserved hypotheticals Rv1533 - 111.9 78.2 53.9 73.8 95.7 81.2 149.01894395004 -0.147026218977505 0.247815198680755 -0.593289756884159 0.55298725266241 0.92521033104044 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1534 - 82.5 65.7 38.6 53.3 78.6 48.5 66.2472361091251 -0.234227498344865 0.320318409218405 -0.731233334095264 0.464636642652979 0.901158530199572 Probable transcriptional regulator I.J.1 - Repressors/activators Rv1535 - 324.2 163.5 147.6 179.5 249 153.9 75.8251365450794 -0.307516675643234 0.298060304478822 -1.03172636886668 0.302200320997589 0.842296632810805 hypothetical protein VI - Unknowns Rv1536 ileS 127 76.2 67.3 82.9 93.8 68.4 431.564901916995 -0.324238238008068 0.188670777313571 -1.71853978991767 0.085698203253166 0.56708428277095 Isoleucyl-tRNA synthetase IleS II.A.3 - Aminoacyl tRNA synthases and their modification Rv1537 dinX 17.3 7.8 12.4 15.9 19.9 6.6 28.9452572630573 -0.0136387049713256 0.447278778406372 -0.0304926270365867 0.975674173421081 0.998153412295216 Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1538c ansA 40 24.6 20.7 35.2 35.2 15.8 43.9673944431252 -0.132257503366161 0.35687548382356 -0.370598456215471 0.710936632075726 0.949890877982223 Probable L-aparaginase AnsA I.A.2 - Amino acids and amines Rv1539 lspA 350.6 190.3 163.1 262.7 263.3 254.2 239.752140553424 -0.0144375387461228 0.210857181251098 -0.0684706997431117 0.945410943539608 0.998153412295216 Probable lipoprotein signal peptidase LspA III.D - Protein and peptide secretion Rv1540 - 278.8 155.3 125.5 260.7 208 118.8 276.764286588203 -0.0921819341592353 0.225066899031733 -0.409575706404691 0.682117220829627 0.942913432418385 Conserved hypothetical protein member of yabO/yceC/yfiI family V - Conserved hypotheticals Rv1541c lprI 5.4 0.7 3.6 4.8 4.4 7.9 3.52953985927615 0.409488536444088 1.12899585057072 0.362701542469875 0.716827847353054 NA Possible lipoprotein LprI II.C.1 - Lipoproteins(lppA-lpr0) Rv1542c glbN 12.5 0 18 1.3 0 0 3.92920978298774 -4.18739896477988 1.50152482549863 -2.78876439048506 0.00529095411422872 NA Hemoglobin GlbN I.B.6.a - aerobic Rv1543 - 234.1 155.2 160.2 144.5 239.9 164.8 307.378424166182 -0.217563468239257 0.249339145684946 -0.872560414216551 0.382902725169737 0.893826103932853 Possible fatty acyl-CoA reductase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1544 - 264.9 153.8 147.8 206.6 180.9 154.8 238.660845936245 -0.243275120184901 0.207294294055246 -1.17357364462751 0.240565842847405 0.78958848015113 Possible ketoacyl reductase I.I - Polyketide and non-ribosomal peptide synthesis Rv1545 - 177.3 59.5 56.5 147.7 153.3 65.2 37.3160361747304 0.168998360035578 0.407313623764335 0.414909667085816 0.678208032745441 0.942913432418385 Hypothetical protein VI - Unknowns Rv1546 - 136.4 88 45.8 162.4 102.9 122 73.4664030426055 0.413834454162876 0.308864314416413 1.33985842600431 0.180291376432287 0.735038480974451 hypothetical protein V - Conserved hypotheticals Rv1547 dnaE1 90.2 64.8 47.4 82 95.1 86.4 443.144508446472 0.206599896868979 0.201143960912808 1.02712453275461 0.304361828074753 0.844880251285152 Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1548c PPE21 13.4 8.3 6.9 5.8 17.9 19.8 38.9534523456094 0.389274905367098 0.47248091874795 0.823895505449524 0.409998934466771 0.901158530199572 PPE family protein PPE21 IV.C.2 - PPE family Rv1549 fadD11.1 16.9 1.9 5.6 13.9 13.9 5.4 6.85162056750771 0.213327742316566 0.841603088795093 0.253477850968897 0.79989897477533 NA Possible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1550 fadD11 10.6 11 9.4 14.8 18.3 3.5 30.7581430401509 0.0140374082910417 0.472370390202336 0.0297169521676176 0.976292792017699 0.998153412295216 Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1551 plsB1 5 2.9 1.6 4 6.3 12.2 15.4010701666307 1.06339161428659 0.631097016783446 1.68498913163375 0.0919906684044083 NA Possible acyltransferase PlsB1 I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1552 frdA 6.9 4.5 4.2 5.4 5.6 12.3 17.8622925243589 0.297089582366986 0.560491280853997 0.53005210342313 0.596075806138619 NA Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1553 frdB 2.2 2.3 1.4 1.8 2.5 0 1.47477980301448 -0.422071478838879 1.65245525006227 -0.255420822332692 0.798398090126835 NA Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1554 frdC 2.4 0 4.9 3.8 0 0 0.998408224325306 -0.634917752177725 2.13038201611367 -0.298029999960275 0.765680266798828 NA Probable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1555 frdD 2.9 0.5 0.8 0.6 5.1 3.1 0.46926317016683 -0.0297867874840618 3.06015858496739 -0.00973373982328411 0.99223372191322 NA Probable fumarate reductase [membrane anchor subunit] FrdD (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1556 - 11.8 10.6 1.8 8.5 11.3 10.2 7.89999573002201 0.155583611893295 0.78821749078015 0.19738665243181 0.843524973966123 NA Possible regulatory protein I.J.1 - Repressors/activators Rv1557 mmpL6 14.4 2.9 6.1 13.1 18.3 9.5 18.8517377728145 0.574113604873891 0.53607105878159 1.07096549136371 0.28418494633496 NA Probable conserved transmembrane transport protein MmpL6 II.C.4 - Conserved membrane proteins Rv1558 - 140.1 73.7 59.5 78.7 68.1 59.6 56.014642416532 -0.565667078925572 0.320366054211203 -1.76568981479122 0.0774479024752855 0.549284354478563 hypothetical protein V - Conserved hypotheticals Rv1559 ilvA 158.2 79 67.2 114 112.2 90 209.796605563225 -0.0937098276676048 0.214106763612572 -0.437678035417758 0.661619693924612 0.939577115195416 Probable threonine dehydratase IlvA I.D.7 - Branched amino acid family Rv1560 vapB11 120.4 78 64.7 209 110.1 58.2 35.5831631243678 0.37386724715778 0.424827472940654 0.88004489109396 0.378834991273755 0.893490749801147 Possible antitoxin VapB11 V - Conserved hypotheticals Rv1561 vapC11 61.3 32.2 29.8 72.2 67 32 30.0662511257414 0.331141629937789 0.41621207924316 0.795607927910061 0.426259957160636 0.901158530199572 Possible toxin VapC11 V - Conserved hypotheticals Rv1562c treZ 26.9 19.3 16.8 21 31.1 29 67.3031267979501 0.135898652175851 0.326253203682164 0.416543502537507 0.677012341403047 0.942908427150467 Maltooligosyltrehalose trehalohydrolase TreZ II.A.8 - Polysaccharides (cytoplasmic) Rv1563c treY 36.8 23.7 10.2 34.8 27.6 24 92.6470934156523 0.181501696722334 0.294035737126233 0.617277676843795 0.537051588360727 0.924361123608528 Maltooligosyltrehalose synthase TreY II.A.8 - Polysaccharides (cytoplasmic) Rv1564c treX 93.3 75.3 38.4 66.5 87.1 81.8 256.03850286463 0.0352642292123222 0.248331016063013 0.142004932655589 0.887076109478322 0.982421186038534 Probable maltooligosyltrehalose synthase TreX II.A.8 - Polysaccharides (cytoplasmic) Rv1565c - 140.6 95.5 54.2 114.2 132.7 77.3 352.039261641139 0.00939961153806335 0.21589818945153 0.0435372411502951 0.965273278512768 0.998153412295216 hypothetical protein II.C.5 - Other membrane proteins Rv1566c - 173.7 99 63.4 155.2 156.8 106.6 135.439754666018 0.180066619874624 0.244508692206207 0.736442611711997 0.461461380384247 0.901158530199572 Possible Inv protein IV.A - Virulence Rv1567c - 48.7 39.3 23.6 24.8 78.1 60.9 20.6447022175854 0.368002156532604 0.551823138470843 0.666884244021327 0.504846075872228 NA Probable hypothetical membrane protein VI - Unknowns Rv1568 bioA 26.8 9.6 8.1 25.5 15.2 15.2 32.9453025140352 0.214044712216518 0.421420383454772 0.507912575233773 0.611514655328213 0.931582271037618 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA I.G.1 - Biotin Rv1569 bioF1 45.8 13.8 13.9 55.1 23.7 16.6 48.189918111457 0.280656124756827 0.421892631690117 0.665231159957708 0.505902653282148 0.915911629458156 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) I.G.1 - Biotin Rv1570 bioD 49.9 29.1 21.3 60.7 31.7 25.7 38.1048919397533 0.119448140801388 0.394364306491558 0.302887809153046 0.761975362125976 0.959593750764785 Dethiobiotin synthetase BioD I.G.1 - Biotin Rv1571 - 28.8 12 9.8 46.7 6.9 10.9 13.9707472781417 0.342724317108375 0.680248223984179 0.5038224357295 0.614386160206622 NA hypothetical protein V - Conserved hypotheticals Rv1572c - 5.6 0 0 6.5 0 20.3 0.766685779989458 1.20576428657033 2.39186487247202 0.504110537533904 0.61418370241262 NA hypothetical protein V - Conserved hypotheticals Rv1573 - 25.1 18.2 3.3 22.3 14.8 9.3 9.24220432326768 -0.09495893843287 0.733858134883563 -0.129396860127382 0.897043632050771 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1574 - 49.7 28.2 22.6 32.4 39.1 14.7 14.7620099519196 -0.404559902743797 0.567805437736495 -0.712497408190628 0.476156815827821 NA Probable PhiRv1 phage related protein IV.B.3 - Phage-related functions Rv1575 - 20 8.4 4.5 17.8 19.5 20.9 11.1826703073173 0.616348715656969 0.657317899290419 0.937672192286752 0.348412898619093 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1576c - 90.7 39.8 30.6 69.7 39 32.9 109.960876553247 -0.283406726206888 0.295415911647779 -0.959348210548628 0.337383355815597 0.854445601186084 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1577c - 170.5 78 81.5 117.3 90.8 75.7 82.5942717789716 -0.377610639044776 0.285978685589984 -1.32041532488952 0.186696389777558 0.739746500217031 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1578c - 32.6 18.2 5.3 26.3 11.8 2.3 10.5333946191101 -0.456852352962218 0.768152867161922 -0.594741453807418 0.552016307720821 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1579c - 18 10.8 6.4 19.9 17.6 8.4 6.06867581881391 0.216568319819114 0.842768429336114 0.256972511404722 0.797199993385184 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1580c - 13.8 4.8 10.7 7.7 27.3 11.2 4.65348067756225 0.214297069356276 0.999313199374343 0.214444349869935 0.83020055977945 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1581c - 4.9 0 2.4 2.9 9.3 0 1.64537038260557 0.546817727105695 1.64735442504015 0.331936903676553 0.739936903622255 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1582c - 12.7 8.6 8.6 14.3 6.5 14.9 24.8866251496012 0.0592370199845378 0.472946293981188 0.125251050147554 0.900324803240916 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1583c - 15.3 14.1 1.5 10.8 13 10.6 6.17324225061454 -0.053204872825497 0.868315948710933 -0.0612736330646499 0.95114128910184 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1584c - 56.2 30.3 7.6 12.7 38.9 42.3 9.95006926252077 -0.249981366047917 0.770877881111002 -0.324281409770948 0.745724992745724 NA Possible PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1585c - 66.5 28.1 41.2 30.2 61.7 45.6 37.5647978436907 -0.275948902156571 0.419190447176487 -0.658290054115645 0.510351767719657 0.915911629458156 Possible phage PhiRv1 protein IV.B.3 - Phage-related functions Rv1586c - 65.5 40 36.1 37.2 56.2 34.2 101.658399993919 -0.35479244143141 0.278766133996185 -1.27272433112792 0.203115880538489 0.763476189246154 Probable PhiRv1 integrase IV.B.3 - Phage-related functions Rv1587c - 35.5 31.1 14.4 20.4 41.1 11.9 40.7191243361983 -0.307371186114778 0.417759532747181 -0.735761034807535 0.461876138203584 0.901158530199572 Partial REP13E12 repeat protein IV.B.2 - REP13E12 family Rv1588c - 56.7 32 28.6 69.4 63.4 37.1 49.2524599149833 0.383029257460371 0.337031464202901 1.13647922566 0.255756055126244 0.800346416224053 Partial REP13E12 repeat protein IV.B.2 - REP13E12 family Rv1589 bioB 92 36.3 49.1 74.2 91.8 78.3 116.501754587032 0.272206575903028 0.277840511340224 0.979722411933308 0.32722316003155 0.853347384539607 Probable biotin synthetase BioB I.G.1 - Biotin Rv1590 - 177.4 71.4 65.5 191.8 136.3 125.6 46.5605384825497 0.38221626004392 0.356084504845614 1.07338638677815 0.283097789870402 0.825259204787765 hypothetical protein V - Conserved hypotheticals Rv1591 - 74.9 40.7 22.1 74.4 78.1 63.2 59.7338102512597 0.503916047456182 0.325645886200915 1.54743563118522 0.121758234852979 0.665646250765128 Probable transmembrane protein V - Conserved hypotheticals Rv1592c - 82.9 36.3 42.2 50.6 35.9 33.6 99.9880288737534 -0.589474589305133 0.276915763941345 -2.12871445422657 0.0332778922303452 0.383527707954728 hypothetical protein V - Conserved hypotheticals Rv1593c - 377.4 226.9 139.2 351.4 283.7 276.7 307.103212423459 0.16638691039794 0.207764586038206 0.80084346216416 0.423222274335412 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1594 nadA 1725 863.1 885.9 1105.9 1113.2 943.5 1861.13499298808 -0.293937915735041 0.172445399368798 -1.70452744353252 0.0882825934934434 0.571985071522678 Probable quinolinate synthetase NadA I.G.7 - Pyridine nucleotide Rv1595 nadB 848 314.6 516.1 681.6 431.3 334.9 1319.43961965365 -0.415204774907787 0.251627635335985 -1.65007621024371 0.0989273497776484 0.616290651993188 Probable L-aspartate oxidase NadB I.G.7 - Pyridine nucleotide Rv1596 nadC 859.7 326.1 378.1 599.2 401.7 394.2 664.827556685596 -0.295974633495286 0.218708309922664 -1.35328480934238 0.17596466022758 0.734764437650925 Probable nicotinate-nucleotide pyrophosphatase NadC I.G.7 - Pyridine nucleotide Rv1597 - 152 37.7 52.9 55.9 73.7 36.9 78.6799436377246 -0.664691436751099 0.348891657805799 -1.90515141844143 0.0567603911791147 0.490622631254473 Hypothetical protein VI - Unknowns Rv1598c - 220.1 142.5 76.4 178.9 214.9 135 102.735389906195 0.127141013602505 0.274300194724041 0.463510475194575 0.642998508116921 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv1599 hisD 226.1 112.2 110.4 170.6 121.5 94.8 290.471598659132 -0.373952010780024 0.216559893313921 -1.72678331641931 0.0842065858585937 0.562597624359589 Probable histidinol dehydrogenase HisD (HDH) I.D.5 - Histidine Rv1600 hisC1 221.8 115.4 107.9 171.7 155.8 166.3 284.831074320476 -0.0126126319191179 0.208400258615692 -0.0605211913022462 0.951740538565275 0.998153412295216 Probable histidinol-phosphate aminotransferase HisC1 I.D.5 - Histidine Rv1601 hisB 200.4 118.2 154 81.6 109.8 105.8 136.1468634177 -0.927780310004548 0.290570984822356 -3.19295579554082 0.00140824502462982 0.0611725004333888 Probable imidazole glycerol-phosphate dehydratase HisB I.D.5 - Histidine Rv1602 hisH 228.2 114.6 121.1 179 136.3 83.8 141.075083184466 -0.38038138169701 0.258022378586058 -1.47421856887558 0.140422751822492 0.682617454377878 Probable amidotransferase HisH I.D.5 - Histidine Rv1603 hisA 187.2 87.1 91.2 136.8 109 65.6 130.925787929532 -0.386241490391092 0.261031361488201 -1.47967465743978 0.13896009193858 0.682181933169668 Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA I.D.5 - Histidine Rv1604 impA 224.6 114.9 136.8 141.7 138.1 126.4 193.888162052019 -0.427537816541261 0.232490896440901 -1.83894433324593 0.0659233741748737 0.514454587842348 Probable inositol-monophosphatase ImpA (imp) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1605 hisF 168.5 71.8 86.9 154.3 102.9 72.9 137.811132743012 -0.148007843312877 0.271391726022341 -0.545366085702602 0.585501760738029 0.928941202821899 Probable cyclase HisF I.D.5 - Histidine Rv1606 hisI 151.2 98 86.9 101.3 140.2 81.4 60.999710792456 -0.258376958935183 0.320090002432288 -0.807200965265513 0.419550709716042 0.901158530199572 Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI I.D.5 - Histidine Rv1607 chaA 39.8 36.8 15.8 50.8 37.1 23.2 56.9092383946075 0.142008416814504 0.349339950874639 0.406504942990227 0.684371625799036 0.942913432418385 Probable ionic transporter integral membrane protein ChaA III.A.2 - Cations Rv1608c bcpB 103.4 75.4 40.7 104.9 107.1 118.8 66.8361738578172 0.431479753643427 0.312845172308472 1.37921180135066 0.167829460501361 0.725041090026968 Probable peroxidoxin BcpB III.F - Detoxification Rv1609 trpE 116 57 53.7 104 95.4 93.7 211.959092887441 0.210592143403432 0.217399614302255 0.968686830836057 0.332701465130226 0.853347384539607 Anthranilate synthase component I TrpE (glutamine amidotransferase) I.D.4 - Aromatic amino acid family Rv1610 - 109 47.8 61.5 143.2 90 109.4 103.98589877068 0.474331340726669 0.283519927296959 1.67300882604225 0.0943255585450249 0.598404804898025 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv1611 trpC 399.6 317.1 201.5 483.9 381.8 290.5 449.926003756414 0.14971622532366 0.200692729072065 0.745997256681382 0.455669072222225 0.901158530199572 Probable indole-3-glycerol phosphate synthase TrpC I.D.4 - Aromatic amino acid family Rv1612 trpB 366.6 362 235.6 355.2 400.5 313.3 682.428593701097 -0.0716960329079834 0.213064670550192 -0.336498926466055 0.736494660982852 0.953719209868244 Tryptophan synthase, beta subunit TrpB I.D.4 - Aromatic amino acid family Rv1613 trpA 300.1 267.9 230.7 344.8 240 275.2 370.092489526474 -0.127242484673432 0.233313817487298 -0.545370548747546 0.585498691815284 0.928941202821899 Probable tryptophan synthase, alpha subunit TrpA I.D.4 - Aromatic amino acid family Rv1614 lgt 450.1 396.8 245.8 505.5 478.7 505.9 977.679693696381 0.263299869297809 0.203547876207879 1.29355252534743 0.195820029914351 0.751109817915875 Possible prolipoprotein diacylglyceryl transferases Lgt III.D - Protein and peptide secretion Rv1615 - 232.8 194.1 102.2 191.1 175.9 159 124.086643854877 -0.165631599725408 0.256969547397646 -0.644557308065388 0.519214108457095 0.915911629458156 Probable membrane protein VI - Unknowns Rv1616 - 136.3 108.2 56.8 111.1 132.4 80.4 65.0675388347511 -0.0620823418263166 0.312812577052059 -0.198464979929451 0.842681281718207 0.974476040705366 hypothetical protein V - Conserved hypotheticals Rv1617 pykA 89.2 57 67.4 89.8 67.8 43.1 159.173349363081 -0.312324069665111 0.266075118907421 -1.17381914907189 0.240467472237189 0.78958848015113 Probable pyruvate kinase PykA I.B.1 - Glycolysis Rv1618 tesB1 115.6 92.5 72.4 113.7 116.8 134.9 157.850385878098 0.184141193354295 0.255120374312572 0.721781605449851 0.4704287604232 0.902597484602108 Probable acyl-CoA thioesterase II TesB1 I.H.1 - Synthesis of fatty and mycolic acids Rv1619 - 29.6 16.8 13.1 37.7 16.6 13.6 47.1318972256141 0.0693747128126809 0.386944209762817 0.179288670207018 0.857711042580946 0.975793048425672 hypothetical protein V - Conserved hypotheticals Rv1620c cydC 192.9 59.9 110.1 103.9 83.4 61.1 282.333767186401 -0.721694769585773 0.27231096088674 -2.65025971498056 0.00804299163814707 0.179410603799313 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC I.B.6.c - Electron transport Rv1621c cydD 128.2 42.9 62.2 81.6 58.5 51 176.27010899247 -0.439076101371582 0.267029575106275 -1.6442976445468 0.100114735652212 0.622286199582063 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD I.B.6.c - Electron transport Rv1622c cydB 145.4 83.1 75 103.8 79.4 63.5 152.130690406733 -0.467472245658439 0.235676008537342 -1.98353769040674 0.0473074013681681 0.437633017338973 Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (cytochrome BD-I oxidase subunit II) I.B.6.c - Electron transport Rv1623c cydA 329.7 239 192.5 168.8 217 219.5 546.750050713102 -0.515511533714884 0.221384596701922 -2.32857904928672 0.0198813770206819 0.292510047017054 Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (cytochrome BD-I oxidase subunit I) I.B.6.c - Electron transport Rv1624c - 61.3 40 22.2 58.3 46.9 26.7 38.262209232878 -0.0178274089007349 0.38122547143342 -0.0467634254177804 0.962701779413831 0.998153412295216 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv1625c cya 187.4 106.9 103.4 102.5 132.5 99 262.584821655381 -0.442529960922233 0.218986909407703 -2.02080554549653 0.0432998985482062 0.418767550294889 Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase) IV.J - Cyclases Rv1626 - 789.5 555.5 331.5 702.1 672.5 494.1 577.053359554067 -0.00087826937663029 0.18741790495931 -0.00468615512920694 0.996261002857644 0.999833281786427 Probable two-component system transcriptional regulator I.J.2 - Two component systems Rv1627c - 178.8 79.1 100.5 160.1 112.9 100.2 234.280685638071 -0.115936363691503 0.235521302656889 -0.49225425633961 0.622539613301499 0.931582271037618 Probable nonspecific lipid-transfer protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1628c - 282.3 86.9 152 163.7 179.5 104.7 125.448284888011 -0.39803421290239 0.295760024592486 -1.34580125711993 0.178366619913074 0.734764437650925 hypothetical protein V - Conserved hypotheticals Rv1629 polA 42.6 11.9 20.3 28.8 33 24 113.235510752011 0.0335403106512119 0.29815215056221 0.112493941727292 0.910431773055063 0.992834063067731 Probable DNA polymerase I PolA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1630 rpsA 591.1 344.7 281.3 561.2 534.4 452.1 1055.60516803263 0.187881459393252 0.162067574984751 1.15927852570713 0.246342672076589 0.791634949201473 30S ribosomal protein S1 RpsA II.A.1 - Ribosomal protein synthesis and modification Rv1631 coaE 308.6 167.3 176.8 327.9 221.4 208.5 458.555086126441 0.0305268721485962 0.205775106966322 0.148350656202513 0.882066039725429 0.980892105790941 Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase) V - Conserved hypotheticals Rv1632c - 118.3 67.8 59.6 88 112.1 103.8 64.812559643842 0.0962156546212825 0.31355763076051 0.30685158064219 0.758956345202406 0.959593750764785 Hypothetical protein VI - Unknowns Rv1633 uvrB 146.1 98.2 86.5 128.6 135.8 88.1 383.305405714687 -0.109790449769626 0.197272101692527 -0.556543215323715 0.577839560337105 0.927628684789573 Probable excinuclease ABC (subunit B-helicase) UvrB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1634 - 92.3 53.1 39.9 84.7 68.5 57.2 146.254154825857 0.036092731910768 0.232864846566826 0.154994334451466 0.87682578378407 0.980703859230131 Possible drug efflux membrane protein III.A.6 - Efflux proteins Rv1635c - 66.7 21.8 36.4 53.4 69.7 53.2 132.346197121291 0.316210106857495 0.287097361954831 1.10140373531974 0.270720980458659 0.812783093966197 Probable mannosyltransferase Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1636 TB15.3 235.1 143.5 95.7 260 209.9 228.7 135.375289237222 0.411106421389032 0.244159685863204 1.68376044528237 0.0922279743977595 0.589151448462362 Iron-regulated universal stress protein family protein TB15.3 V - Conserved hypotheticals Rv1637c - 50.3 26 19.7 45.4 53.9 37 47.5633744171278 0.327341383113331 0.341836408910212 0.957596600540322 0.338266214025109 0.854469724194934 hypothetical protein V - Conserved hypotheticals Rv1638 uvrA 80.4 41.5 38.4 70.8 62.5 49.8 263.616726886612 0.027492246795584 0.201912121517486 0.136159466747038 0.891695217531606 0.985189043752372 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1638A - 174.8 87.8 118.5 149.4 180.3 133.2 58.0892512627545 0.0748234269083389 0.33088639906876 0.226130258357311 0.821100111275768 0.967275514390449 hypothetical protein ? Rv1639c - 245 167.3 126.8 194.6 160.9 124 400.314843334525 -0.345742274120834 0.189806353405405 -1.82155269261387 0.0685228845727977 0.520912460856883 hypothetical protein V - Conserved hypotheticals Rv1640c lysX 12.8 6.9 6.9 11.1 18.2 11.9 62.2641237511264 0.423259438106992 0.329338457759476 1.28518072558689 0.198729137379252 0.755061530207431 Lysyl-tRNA synthetase 2 LysX II.A.3 - Aminoacyl tRNA synthases and their modification Rv1641 infC 747 580.4 466.3 618.2 780.4 671.3 635.377843849028 0.00646868521321071 0.207502571772778 0.0311740001964608 0.975130774671336 0.998153412295216 Probable initiation factor if-3 InfC II.A.6 - Protein translation and modification Rv1642 rpmI 891.3 548.6 690.6 462 696.4 753.3 219.292873421661 -0.38490180792089 0.288783497104009 -1.33283865518902 0.182584757368094 0.736194517318001 50S ribosomal protein L35 RpmI II.A.1 - Ribosomal protein synthesis and modification Rv1643 rplT 681.9 348.8 425.5 469.9 636.3 438.6 314.225094328239 -0.11650234800724 0.230530220603725 -0.505366921968569 0.613301147170249 0.931582271037618 50S ribosomal protein L20 RplT II.A.1 - Ribosomal protein synthesis and modification Rv1644 tsnR 422.5 212.7 242.4 420.4 336.2 261.4 393.031975350738 0.026996093245729 0.206370121292561 0.130813962198811 0.895922477674422 0.987900395428749 Possible 23S rRNA methyltransferase TsnR II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1645c - 30.1 21.2 6.9 20.1 22.7 40.2 39.0671245872928 0.392939854816116 0.447203129330249 0.878660789795009 0.379585224590122 0.893490749801147 hypothetical protein V - Conserved hypotheticals Rv1646 PE17 201.3 104.9 68.3 190 169.6 190.2 224.265279042888 0.435637177995033 0.232963195124335 1.86998284326642 0.061486200394807 0.512261537024205 PE family protein PE17 IV.C.1.a - PE subfamily Rv1647 - 22.4 14.4 9.6 17.1 22.4 8.9 23.4125785015335 -0.0783726662622316 0.460318961923489 -0.170257305792365 0.864807786017532 NA Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) V - Conserved hypotheticals Rv1648 - 31.5 22.5 4.9 20.9 21.7 10.5 22.476625974747 -0.231828716423008 0.51303413729555 -0.451877759334084 0.651357047516924 NA Probable transmembrane protein II.C.5 - Other membrane proteins Rv1649 pheS 34.7 18.1 18.1 28.8 34.9 14.3 39.5127200067226 -0.0398135062233709 0.376950162212098 -0.10562007982628 0.915883792467308 0.9932884147079 Probable phenylalanyl-tRNA synthetase, alpha chain PheS II.A.3 - Aminoacyl tRNA synthases and their modification Rv1650 pheT 41.2 20.2 20 56.5 45.3 28.3 135.556792693256 0.513704217817007 0.254047237289173 2.02208149672683 0.0431679332303437 0.418767550294889 Probable phenylalanyl-tRNA synthetase, beta chain PheT II.A.3 - Aminoacyl tRNA synthases and their modification Rv1651c PE_PGRS30 16.5 10.9 8.5 17.9 12 10.6 60.817556244274 0.00229696839488263 0.316311507404408 0.00726172883728167 0.994206029597997 0.999833281786427 PE-PGRS family protein PE_PGRS30 IV.C.1.b - PE_PGRS subfamily Rv1652 argC 21.2 17.9 9.2 9.7 6.9 8.4 20.6803084095066 -1.15566304522736 0.504517643963813 -2.29062959255049 0.0219848458959088 NA Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC I.D.1 - Glutamate family Rv1653 argJ 32.6 9.2 20.4 25.5 16 16 38.0243231279388 -0.30030953424003 0.418717775854889 -0.71721228846063 0.473243118046659 0.904373078832156 Probable glutamate N-acetyltransferase ArgJ I.D.1 - Glutamate family Rv1654 argB 37.2 10 12.8 30.3 27.3 9.6 27.6229767878303 0.0553873130589416 0.469841184838326 0.117885180878727 0.906158635313074 0.992210970746976 Probable acetylglutamate kinase ArgB I.D.1 - Glutamate family Rv1655 argD 26.2 13 17.8 21.4 16.4 9.4 33.0857282743351 -0.478171218815869 0.416236768971225 -1.14879620077227 0.250640026348643 0.796128980119145 Probable acetylornithine aminotransferase ArgD I.D.1 - Glutamate family Rv1656 argF 21.7 14.5 7.6 28.7 18.8 8.9 23.0385845095356 0.216254190341893 0.487748091962455 0.443372703872187 0.657496176116564 NA Probable ornithine carbamoyltransferase, anabolic ArgF I.D.1 - Glutamate family Rv1657 argR 19.8 17.7 15.7 26.6 18.8 18.3 15.5030145256062 0.0912738332775582 0.554672973082303 0.164554318863513 0.86929478920494 NA Probable arginine repressor ArgR (AHRC) I.J.1 - Repressors/activators Rv1658 argG 86.8 62.9 55.2 75.5 70.2 61.8 133.091777562952 -0.182535572843771 0.245007641506747 -0.745019917424677 0.45625967929101 0.901158530199572 Probable argininosuccinate synthase ArgG I.D.1 - Glutamate family Rv1659 argH 40.7 16 20.6 36.7 22.1 21 57.697134095642 -0.102725623249334 0.340480593991506 -0.301707718625209 0.762874883718947 0.959593750764785 Probable argininosuccinate lyase ArgH I.D.1 - Glutamate family Rv1660 pks10 32 18.9 18.2 30 30.4 10.7 38.6874157318447 -0.133730638085174 0.389589846948174 -0.343260069872828 0.731402817487617 0.951379060695889 Chalcone synthase Pks10 I.I - Polyketide and non-ribosomal peptide synthesis Rv1661 pks7 19 15.9 14.6 27 17.4 20 197.627871743826 0.153497035446773 0.253995565226707 0.604329588627926 0.545624538196323 0.92521033104044 Probable polyketide synthase Pks7 I.I - Polyketide and non-ribosomal peptide synthesis Rv1662 pks8 17.4 14.1 16.2 25.3 13.4 18.4 138.47097211882 0.0200019795295493 0.300942802722265 0.0664643890753182 0.947008108395613 0.998153412295216 Probable polyketide synthase Pks8 I.I - Polyketide and non-ribosomal peptide synthesis Rv1663 pks17 24.7 18.7 21.5 25 19.8 21.3 54.1095378523766 -0.215259502677327 0.348565738274247 -0.617557834981372 0.536866846311522 0.924361123608528 Probable polyketide synthase Pks17 I.I - Polyketide and non-ribosomal peptide synthesis Rv1664 pks9 30.1 26.3 22 24.9 24.5 29.8 132.656599873997 -0.212478947316069 0.276489812617232 -0.768487436498145 0.442197651842413 0.901158530199572 Probable polyketide synthase Pks9 I.I - Polyketide and non-ribosomal peptide synthesis Rv1665 pks11 42.4 17.7 12.7 56.8 40 34.6 54.5497930952532 0.714767156141474 0.344308484787051 2.07594987554125 0.0378985871321413 0.401181069479615 Chalcone synthase Pks11 I.I - Polyketide and non-ribosomal peptide synthesis Rv1666c cyp139 24.8 10.3 12.1 27.3 25.1 4 33.6960109853284 0.133577085567471 0.454730571403824 0.293749956496433 0.768948977662664 0.961099354819217 Probable cytochrome P450 139 Cyp139 IV.F - Cytochrome P450 enzymes Rv1667c - 20.3 11.2 11.4 16.2 22.5 21.1 17.6240684203212 0.246605460190371 0.52492565614079 0.469791211965887 0.638504193630038 NA Probable second part of macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1668c - 29 26.9 19.9 26.7 26.4 15.9 43.639810190494 -0.328371786269789 0.367032292147134 -0.894667290305215 0.370964969075533 0.885048465556592 Probable first part of macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1669 - 4.7 9 0 2.2 4.6 0 1.73547095424065 -1.32592830496376 1.68934397415204 -0.784877636083146 0.432525315427323 NA Hypothetical protein VI - Unknowns Rv1670 - 19.1 2.5 0.5 8.2 0 5.4 2.37780200905827 -0.457050581429651 1.57988032192294 -0.289294432677884 0.772356072347174 NA hypothetical protein V - Conserved hypotheticals Rv1671 - 5.9 2.2 2.3 5.3 9.4 1.9 1.95811987230114 0.660436253654845 1.51274662368851 0.436580880970344 0.662415330697515 NA Probable membrane protein II.C.5 - Other membrane proteins Rv1672c - 24.1 15 10.7 20.9 15.5 6.2 31.3712261395723 -0.369005966374352 0.429440105160358 -0.859272252265681 0.390190329140147 0.893826103932853 Probable conserved integral membrane transport protein II.C.5 - Other membrane proteins Rv1673c - 4.3 3.7 4.1 5 8.6 7.6 8.00988880210508 0.673380097429171 0.7634355002067 0.882039278035739 0.377755567086891 NA hypothetical protein V - Conserved hypotheticals Rv1674c - 3.7 0 0.7 4 5.1 5 2.27758378860417 1.41923242714012 1.47736326212498 0.960652307746408 0.336727018622401 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1675c cmr 2.4 3.2 0 3.8 2.4 3.1 2.37493888051686 0.535031448697562 1.36627347916273 0.391599088218732 0.695354461703023 NA Probable transcriptional regulatory protein Cmr I.J.1 - Repressors/activators Rv1676 - 297.4 218.1 184 253.3 380.3 248.8 299.537001081488 0.129365183641423 0.231500352115497 0.558812038337124 0.576290005740548 0.926626101773025 hypothetical protein IV.F - Cytochrome P450 enzymes Rv1677 dsbF 240.1 124.1 100.5 219.2 190.1 217.8 157.19458281194 0.288158414019038 0.239664218035527 1.20234224525049 0.229230955738469 0.784559243948471 Probable conserved lipoprotein DsbF II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1678 - 139.9 105.9 90.7 183 125.9 115.4 183.753160680117 0.136470144220805 0.238233444637706 0.572842089524173 0.566751617908314 0.92521033104044 Probable integral membrane protein II.C.5 - Other membrane proteins Rv1679 fadE16 96.1 66.2 43.2 94.6 78.5 75.4 134.077771848222 0.115776377901217 0.239303186937677 0.483806251737755 0.628523377826782 0.93413540068838 Possible acyl-CoA dehydrogenase FadE16 I.A.3 - Fatty acids Rv1680 - 62.1 51.8 34.6 53.8 57.3 45.2 67.4732391704784 -0.108600470186717 0.303999951854889 -0.357238445348691 0.720913306964346 0.949890877982223 Hypothetical protein VI - Unknowns Rv1681 moeX 46.1 29.8 19.9 54.1 36.7 23.2 53.2646407111445 0.121941702886037 0.342089528084218 0.356461373047398 0.721495074587138 0.949890877982223 Possible molybdopterin biosynthesis protein MoeX I.G.4 - Molybdopterin Rv1682 - 86.1 45.8 47.6 33.2 50.7 37.1 74.4447366575553 -0.779664917824667 0.313482013556978 -2.48711212799122 0.012878480135196 0.248138755974156 Probable coiled-coil structural protein V - Conserved hypotheticals Rv1683 - 91.8 57.6 43.5 70.2 75.6 58 315.806843930708 -0.0881093347752673 0.194069652474187 -0.454008824419298 0.649822475418599 0.939577115195416 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase I.A.3 - Fatty acids Rv1684 - 45 14.9 28.6 27.2 68.1 6.9 10.4035105449902 -0.157589999795618 0.741726637076288 -0.212463719001385 0.831745279670123 NA hypothetical protein V - Conserved hypotheticals Rv1685c - 8 0.3 3.5 12.5 14.3 13.6 8.12739920685387 1.54776342695315 0.79809023652243 1.93933386993596 0.0524606972179973 NA hypothetical protein V - Conserved hypotheticals Rv1686c - 13.8 10.2 8 6.7 10.2 5.3 9.51918059185578 -0.739510415917418 0.696326778459963 -1.06201633887033 0.288228267820865 NA Probable conserved integral membrane protein ABC transporter II.C.5 - Other membrane proteins Rv1687c - 8 10.3 4.8 8.6 2.4 0 6.59274747836583 -0.997280644025643 0.92803676378498 -1.07461329436805 0.282547897287012 NA Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1688 mpg 4 0 0 4 6 8.6 3.31182125818251 1.80907814965439 1.3038576841191 1.38748129622492 0.165295050569365 NA Possible 3-methyladenine DNA glycosylase Mpg II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1689 tyrS 35 30.6 20.7 31.1 26.1 28.1 59.2917260449949 -0.192964938844874 0.322659747952644 -0.598044658713349 0.549810135038057 0.92521033104044 Probable tyrosyl-tRNA synthase TyrS (TYRRS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1690 lprJ 51.3 39.3 20.3 80 96.5 65.5 34.4114007112346 0.972845739617543 0.392579688823472 2.47808474894124 0.0132089766226611 0.251972616126073 Probable lipoprotein LprJ II.C.1 - Lipoproteins(lppA-lpr0) Rv1691 - 28 18.9 11.6 39.6 17.5 26.5 26.9764801730813 0.383793426561945 0.451181638997813 0.850640614308788 0.394969021029876 0.893826103932853 hypothetical protein VI - Unknowns Rv1692 - 37.3 17.6 16.3 46.8 33.4 23.2 47.2735288655762 0.401289666077051 0.350559338734936 1.14471252577434 0.25232826100207 0.796502243851669 Probable phosphatase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1693 - 211.8 134.4 76.2 210.6 153.3 175.2 44.3497086614953 0.201225730082491 0.354715943030466 0.567286963093192 0.570519232926152 0.925417141377798 hypothetical protein VI - Unknowns Rv1694 tlyA 78.3 64.7 32.1 93.5 70.8 45.7 80.6932393571118 0.123804616618466 0.30358802426222 0.407804678459686 0.683417078585212 0.942913432418385 2'-O-methyltransferase TlyA IV.A - Virulence Rv1695 ppnK 66.7 41.4 40.1 86.3 69.4 29.5 80.5002978040044 0.144883198353846 0.312782798738036 0.463207052748414 0.643215961395978 0.939577115195416 Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) V - Conserved hypotheticals Rv1696 recN 47 27.9 25.5 70.2 36.3 48.5 118.22000746961 0.464551420893094 0.27786916409076 1.6718350969716 0.0945568439208003 0.598499382803052 Probable DNA repair protein RecN (recombination protein N) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1697 - 234.8 178.5 104.1 257 263.3 202.3 385.897087237287 0.319429264019913 0.198972078435743 1.60539743330405 0.108406368913839 0.643080319504058 hypothetical protein V - Conserved hypotheticals Rv1698 mctB 150.6 103.5 64.7 129.5 155.8 126.7 182.200412322575 0.206827761987278 0.231277513601513 0.894283922230497 0.371170000016503 0.885048465556592 Outer membrane protein MctB V - Conserved hypotheticals Rv1699 pyrG 142.9 89.9 84.9 119.6 160.5 118.6 338.072037310014 0.130536146620244 0.21544258785877 0.605897598602069 0.544582754189421 0.92521033104044 Probable CTP synthase PyrG I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1700 - 143.3 75.6 73.4 147.5 85.2 95.2 102.209762299167 0.0158808183778801 0.276576448875951 0.0574192721123661 0.954211211402216 0.998153412295216 NUDIX hydrolase V - Conserved hypotheticals Rv1701 - 75.4 54.6 43.8 89.3 86.6 43 96.4765072185123 0.156096877334171 0.280256529130699 0.556978557532105 0.577542079530485 0.927628684789573 Probable integrase/recombinase IV.B.3 - Phage-related functions Rv1702c - 20.3 17.4 13.8 12.6 37.4 18.5 43.5247234881524 0.174438182992859 0.431752385476658 0.404023669261903 0.686195313905026 0.942913432418385 hypothetical protein IV.B.2 - REP13E12 family Rv1703c - 150.8 98.4 70.6 115.9 144.8 119.9 109.542189367008 0.0723020108623506 0.261852066161935 0.276117778721813 0.782457605848437 0.963989543249515 Probable catechol-O-methyltransferase IV.H - Miscellaneous transferases Rv1704c cycA 29.1 15.8 15.5 27.3 27.4 21.7 60.098684313287 0.155081650567481 0.308138838607924 0.503284984353455 0.614763921977687 0.931582271037618 Probable D-serine/alanine/glycine transporter protein CycA III.A.1 - Amino acids Rv1705c PPE22 12.5 5.9 6.9 4.7 6.6 2.2 11.242975884194 -1.18974058579929 0.662450478578677 -1.7959690939494 0.0724994324659106 NA PPE family protein PPE22 IV.C.2 - PPE family Rv1706c PPE23 22.7 5.8 7.5 11.7 6.2 0 15.2991033534202 -0.997164112387419 0.661376350032574 -1.50771056802728 0.131628619579296 NA PPE family protein PPE23 IV.C.2 - PPE family Rv1706A - 0 0 0 0 8.1 0 0.267659641823671 1.75737196211165 4.00124364658916 0.439206436131354 0.660511961931982 NA hypothetical protein ? Rv1707 - 59.6 40 26.3 40.1 52.9 49.1 103.967958184165 0.000318022594242878 0.277783843160174 0.00114485634090498 0.9990865370008 0.999833281786427 Probable conserved transmembrane protein III.A.4 - Anions Rv1708 - 74.1 74.5 37.8 78.5 84.3 74.9 108.570864240451 0.177458921321282 0.280269353098694 0.633172765267672 0.526620828662978 0.921428654655606 Putative initiation inhibitor protein III.C - Cell division Rv1709 scpA 84.4 81.7 44.2 114.1 100.4 103.7 117.987793477859 0.426693045247079 0.271279894966968 1.57288856698737 0.115744622881051 0.652035899977573 Possible segregation and condensation protein ScpA V - Conserved hypotheticals Rv1710 scpB 96.5 42.6 35.9 85.5 79.7 60.2 71.2396767426435 0.227288843156317 0.299861457067111 0.757979519540079 0.448463243514459 0.901158530199572 Possible segregation and condensation protein ScpB V - Conserved hypotheticals Rv1711 - 101.6 80.1 40.7 200.6 120.9 70.9 119.745323325301 0.665126523408329 0.304792434124925 2.1822278014149 0.0290927244361523 0.361311748957762 hypothetical protein V - Conserved hypotheticals Rv1712 cmk 141.3 80.7 70.2 160.6 136 125.4 130.239358508108 0.366016390507052 0.237771261945066 1.53936345171779 0.123715591363048 0.666956030977941 Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv1713 engA 115.7 83.4 49.3 162.1 108.5 92.9 221.992680374592 0.400093006187283 0.230963554947284 1.7322776586055 0.0832241378285252 0.562041621739757 Probable GTP-binding protein EngA V - Conserved hypotheticals Rv1714 - 28.8 19.3 11.4 40.8 27.3 25.3 32.0886833329026 0.541997103643896 0.401758524964451 1.34906186170375 0.177317096951805 0.734764437650925 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1715 fadB3 13.1 23.2 8.2 21.8 15.1 6.9 21.0944173661799 -0.157615426419492 0.552939087677126 -0.285050252246822 0.775605642463864 NA Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) I.A.3 - Fatty acids Rv1716 - 27 21.2 12.1 31 49.8 26.4 35.6800243339876 0.647828067895153 0.401195548407435 1.61474390846742 0.106366164624067 0.640977802505815 hypothetical protein V - Conserved hypotheticals Rv1717 - 15.3 3 1.8 22.5 26.5 28.8 8.00807270462355 1.5992140451311 0.810081263225443 1.97414027175944 0.0483657952565906 NA hypothetical protein V - Conserved hypotheticals Rv1718 - 23.3 20.3 12.4 29.7 18.8 32.5 29.4916597677485 0.344671773622574 0.433127295198169 0.795774769781885 0.426162958926442 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1719 - 9.2 15.9 6.4 21.1 12 6.8 14.5402294547549 0.253275665235312 0.623215867365679 0.406401182155235 0.684447851233168 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1720c vapC12 57.4 15.5 21.2 41.5 18.8 21.3 16.3738565920145 -0.34006654157441 0.581250033357806 -0.585060683110657 0.558506914245221 NA Possible toxin VapC12 V - Conserved hypotheticals Rv1721c vapB12 47.3 23.5 17.3 36.5 34.9 0 9.07957817318802 -0.352208879848628 0.73995276666737 -0.475988327518419 0.634082693704519 NA Possible antitoxin VapB12 VI - Unknowns Rv1722 - 17.4 11 9.4 21 16.1 19.1 36.1780081119151 0.395033971074333 0.378309839131884 1.04420749928372 0.29638939807726 0.837161771605085 Possible carboxylase I.H.1 - Synthesis of fatty and mycolic acids Rv1723 - 9.8 6.8 5.3 7.8 13.4 4.5 15.3537357853829 0.0438496124194621 0.563243520364756 0.0778519607133076 0.93794581316487 NA Probable hydrolase II.B.6 - Aromatic hydrocarbons Rv1724c - 27.6 39 14.7 11.5 27.2 46.9 18.9202349888651 -0.180221457237862 0.615803015895535 -0.292660887631045 0.769781368636254 NA Hypothetical protein VI - Unknowns Rv1725c - 22.8 13.4 8.3 12.4 24.6 22.5 19.0244224024317 0.160514441251871 0.531466503259702 0.302021745994094 0.762635485673316 NA hypothetical protein V - Conserved hypotheticals Rv1726 - 1 0 0.8 0 0 0 0.507241575400845 -2.14382122601925 2.91865862008243 -0.734522774012779 0.462630185352195 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1727 - 1.2 0 1.3 0 0 0 0.372839223172073 -1.70854621948497 3.29624989327708 -0.518330307107378 0.604227830850202 NA hypothetical protein V - Conserved hypotheticals Rv1728c - 65.8 45.7 28.5 53.1 85.1 69.9 70.7888913939743 0.384937718818083 0.322180301921388 1.19478973892081 0.232169190378982 0.78809468487714 hypothetical protein V - Conserved hypotheticals Rv1729c - 23 16.7 6 15 10.7 12 19.8936934319286 -0.401908144177214 0.511604193905673 -0.785584146816661 0.432111155060844 NA Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv1730c - 39.9 32.6 16.6 24.7 32 38.6 77.0124749015205 -0.0935056921162715 0.329203305638451 -0.284036309826623 0.7763825548356 0.963013023606306 Possible penicillin-binding protein II.C.3 - Murein sacculus and peptidoglycan Rv1731 gabD2 66.6 32.9 29.5 77 60.1 27.1 116.646783284754 0.196298274984518 0.289480302141331 0.678105810766636 0.49770460670116 0.914110851351534 Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 I.A.1 - Carbon compounds Rv1732c - 183.9 91.4 132 112.8 102.4 59.5 101.84377259663 -0.779114816562803 0.296018770829352 -2.63197774377607 0.00848894236267832 0.182905478971198 hypothetical protein V - Conserved hypotheticals Rv1733c - 522.7 182.8 425.8 101.7 2.9 43.4 233.835450186252 -3.20684863875805 1.2174878763201 -2.63398814980471 0.00843884331335415 0.182905478971198 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1734c - 41.9 21.1 27.8 4.5 4.5 1.6 6.74614893062714 -3.35542121253087 1.04478640474509 -3.21158582968881 0.00132004532172703 NA hypothetical protein VI - Unknowns Rv1735c - 87.9 40.1 65.1 11.2 0 15.9 31.1579990236536 -3.21215124901009 0.55266688456479 -5.81209285144626 6.16966017098589e-09 1.42210666941225e-06 Hypothetical membrane protein VI - Unknowns Rv1736c narX 1443.1 775.2 986.5 270.9 6 155.8 2039.246264721 -3.10634255248229 1.1924665453806 -2.60497249546808 0.00918816354816433 0.194003514307042 Probable nitrate reductase NarX I.B.6.b - anaerobic Rv1737c narK2 1025.4 460.2 631 287.4 5.6 150 849.456751476545 -2.45841978008229 1.19955403872527 -2.04944479424602 0.0404186408718803 0.409898801332397 Possible nitrate/nitrite transporter NarK2 III.A.4 - Anions Rv1738 - 16936.9 8529.8 11592.9 5600.6 177.7 3676 3750.83643109903 -2.1715521563626 1.12922931482698 -1.92303912752683 0.0544751361308392 0.485439307271885 hypothetical protein V - Conserved hypotheticals Rv1739c - 11.5 4.1 2.5 6.7 15 10.5 20.815877811313 0.681962831874164 0.545215482957639 1.2508133998226 0.211002564903156 NA Probable sulphate-transport transmembrane protein ABC transporter III.A.4 - Anions Rv1740 vapB34 103.1 57.2 43.4 47.6 72.9 85.6 22.6547114734854 -0.224616843587352 0.48840110714061 -0.459902404608361 0.64558627415008 NA Possible antitoxin VapB34 V - Conserved hypotheticals Rv1741 vapC34 122.1 57.8 29.4 89.5 61.9 77 27.1905389865765 0.0105676578175066 0.453458124386422 0.0233045947336499 0.981407306642927 0.998667985896356 Possible toxin VapC34 Contains PIN domain V - Conserved hypotheticals Rv1742 - 33.1 17.1 6.2 28 13.4 6.4 18.6290036902144 -0.283285974338805 0.579244736870167 -0.489060937988809 0.624798555155434 NA hypothetical protein VI - Unknowns Rv1743 pknE 89.7 69.6 39.6 67.6 59.9 68.9 180.128137588308 -0.177890954288218 0.241973810397292 -0.735166148750324 0.462238312355901 0.901158530199572 Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1744c - 3.2 4.3 2.5 2.7 0.7 0 1.06553634456207 -1.13170757248312 1.98575366436705 -0.569913374851482 0.568736452931107 NA Probable membrane protein VI - Unknowns Rv1745c idi 3.6 0 2.2 0.6 6 4.5 2.33056207944278 0.232356045336884 1.44406272646441 0.160904399150151 0.872168697434383 NA Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) V - Conserved hypotheticals Rv1746 pknF 41.9 39.9 24.9 35.9 51.5 22 82.6991274243153 -0.169025134772052 0.315925525026668 -0.535015759672422 0.592638959644925 0.928941202821899 Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1747 - 174.1 118.8 84.3 179.6 155.7 150.7 595.470219307709 0.201213285267809 0.17967610976305 1.11986666192384 0.262770586788488 0.806685286411718 Probable conserved transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1748 - 17 10.6 13.6 14.7 12.4 19.1 17.246699159376 -0.0741672034883133 0.540161731503186 -0.137305549732147 0.890789283933818 NA hypothetical protein VI - Unknowns Rv1749c - 56.9 26.1 20.2 61.6 27.6 30.6 31.5313706362874 0.10197476011356 0.433329470423222 0.23532846730679 0.813953801730075 0.966389401486634 Possible integral membrane protein II.C.5 - Other membrane proteins Rv1750c fadD1 20.7 20.7 11.6 14.6 37.1 13.5 49.9656241041809 0.0778784426644673 0.410158048262702 0.18987422773815 0.849407688354153 0.975474031954732 Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1751 - 125.8 105.4 67.2 191.3 154.4 108 273.128647458755 0.418685189580383 0.220969146114938 1.89476764942831 0.0581231908593893 0.497736055470808 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1752 - 54.5 53.3 29.7 68.1 47.8 53.2 36.7080019237195 0.159263880003529 0.390659881734031 0.407679128188442 0.683509262731165 0.942913432418385 hypothetical protein VI - Unknowns Rv1753c PPE24 8.4 5.5 9.3 5.1 6.7 6.7 36.9790389694045 -0.634310483868043 0.438497953118252 -1.44655289576001 0.148022187051511 0.695223866622759 PPE family protein PPE24 IV.C.2 - PPE family Rv1754c - 15.3 12.4 7.5 14.3 20.9 9.8 34.9051990200875 0.163296589024814 0.39854333537806 0.409733583601166 0.682001391515712 0.942913432418385 hypothetical protein V - Conserved hypotheticals Rv1756c - 4.8 4.4 2.3 1.8 3.9 2.8 4.72232591979309 -0.905312474063857 0.98698298111439 -0.917252365427497 0.359010412271487 NA Putative transposase IV.B.1.a - IS6110 Rv1757c - 9.3 16.4 7.9 11.2 13 11.8 5.93451853167698 -0.206667406033358 0.887282066293247 -0.232921878942896 0.81582206870324 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1758 cut1 0 0 0 0 0 0 0 NA NA NA NA NA Probable cutinase Cut1 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1759c wag22 4.8 4.1 4.8 6.1 3.6 3.9 20.0177788210846 -0.216089624843558 0.51967031450287 -0.4158206055127 0.677541279635751 NA PE-PGRS family protein Wag22 IV.C.1.b - PE_PGRS subfamily Rv1760 - 7.9 6 2 10.1 9.2 10.4 17.1665659787973 0.803326717797406 0.540204004271645 1.48708027235105 0.136993611190233 NA Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv1761c - 9.2 6.7 5.8 14 10 9.7 5.12975549656536 0.549846876715583 0.906233843521752 0.606738404933985 0.544024530801272 NA Possible exported protein VI - Unknowns Rv1762c - 25.1 15.3 17.5 16.6 19.7 29.6 26.2421642465705 -0.0826085726704142 0.465607882687433 -0.177420906608383 0.859177786715615 NA hypothetical protein VI - Unknowns Rv1763 - 12.6 10.4 7.8 16.5 6.8 11.2 5.59248231757005 0.0363714210400975 0.881033920986638 0.0412826568577138 0.967070559105713 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1764 - 5.3 2.2 1.6 8.2 8.3 6.8 7.37654234433548 1.11793217592214 0.780462774126827 1.43239653828829 0.152030368696043 NA Putative transposase IV.B.1.a - IS6110 Rv1765c - 52.9 38.2 22 64.5 46.6 17.8 68.1124008862498 0.0619848941099788 0.346377055239804 0.178952078875621 0.857975329708498 0.975793048425672 hypothetical protein V - Conserved hypotheticals Rv1765A - 2.8 0 0 0 0 8.8 0.61792049896075 0.383958750003277 2.81804272561498 0.136250152104946 0.891623529150787 NA Putative transposase (fragment) ? Rv1766 - 78.3 29.2 41.9 80.8 80.7 40.7 23.8578495997305 0.255157676677338 0.463244477135767 0.550805652891912 0.581766908629505 NA hypothetical protein V - Conserved hypotheticals Rv1767 - 38.3 43.9 9.9 43 37 24.3 18.1825459331498 0.113815730615997 0.547669451349187 0.207818293197861 0.835370848533989 NA hypothetical protein V - Conserved hypotheticals Rv1768 PE_PGRS31 25.2 19 13.1 41.8 21.7 22 69.294278776866 0.437059690207712 0.321543791340175 1.3592540175821 0.174066109484799 0.732826269155182 PE-PGRS family protein PE_PGRS31 IV.C.1.b - PE_PGRS subfamily Rv1769 - 90.2 80.8 60.1 119.2 48.8 71 158.632392874061 -0.159184858601229 0.297163694720979 -0.535680708744367 0.592179238443234 0.928941202821899 hypothetical protein VI - Unknowns Rv1770 - 114.2 83.3 55 98 72.4 75.9 171.418913811495 -0.199374764880832 0.230903299846947 -0.863455676090323 0.38788697927172 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv1771 - 102.7 74.6 57.6 83.5 79 69.9 161.325431159795 -0.207989183725325 0.228513808624701 -0.910182124122375 0.362726469836336 0.882928450686174 L-gulono-1,4-lactone dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1772 - 264.9 180.3 103.4 237.7 216.7 228.5 101.431220802194 0.171107613120165 0.268341562903195 0.637648567254909 0.523702472957942 0.919951162527736 Hypothetical protein VI - Unknowns Rv1773c - 7 2.9 3.4 5.6 19.7 3.8 7.33890869454648 0.921175045644283 0.847780661346204 1.08657237378066 0.277225839751356 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1774 - 30.3 24.8 6.1 29.5 49.5 19.3 54.0167162314121 0.573874572369121 0.406557419363615 1.41154618028471 0.158083628905639 0.708520877886452 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1775 - 70.8 40.4 32.5 50.1 64 48 65.7612723783471 -5.11040212653886e-05 0.305698050216206 -0.000167171564323832 0.999866616390442 0.999866616390442 hypothetical protein V - Conserved hypotheticals Rv1776c - 21.6 11.5 3.6 18 27.5 10.1 12.3742442141054 0.434737549695222 0.638458491257661 0.680917484296995 0.495923704128716 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv1777 cyp144 5.2 7.3 4.7 5.9 7.1 0 10.5375579920654 -0.523506839999022 0.721051767107096 -0.726032254382184 0.467818997642226 NA Probable cytochrome P450 144 Cyp144 IV.F - Cytochrome P450 enzymes Rv1778c - 123.2 39 50.9 107.2 93.2 66.5 54.9356947494239 0.158410305318093 0.342412122482119 0.462630540559687 0.643629213658835 0.939577115195416 hypothetical protein VI - Unknowns Rv1779c - 114.1 63 60.9 123.8 81.2 75.2 245.390167768143 0.0639262533766932 0.221434838996844 0.288691037355709 0.772817821972315 0.962433896292784 Possible integral membrane protein II.C.5 - Other membrane proteins Rv1780 - 47.6 40.1 22.2 47.2 76.1 54.4 42.4638948618603 0.530319312457253 0.377868287080231 1.40345017189721 0.160482640741111 0.71365753101272 hypothetical protein V - Conserved hypotheticals Rv1781c malQ 7.8 2.4 3 4.4 4.2 1.3 12.3068741052714 -0.60187426460296 0.639976299255395 -0.940463366070327 0.346979932249018 NA Probable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme) II.A.8 - Polysaccharides (cytoplasmic) Rv1782 eccB5 219 91 111.6 200.7 114.8 150.8 356.927082901067 -0.00455683499926753 0.243254117460166 -0.0187328175442446 0.985054248229571 0.999019127881181 ESX conserved component EccB5 ESX-5 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv1783 eccC5 228.6 106.9 110.4 178.2 150.2 133.2 1001.06799292846 -0.102713570078344 0.180104478540295 -0.570299922083078 0.568474293741871 0.92521033104044 ESX conserved component EccC5 ESX-5 type VII secretion system protein V - Conserved hypotheticals Rv1785c cyp143 17.9 8.3 10 18.2 14.3 12 24.6557964276794 0.12175498178605 0.445196674491223 0.273485829437502 0.784479783769128 NA Probable cytochrome P450 143 Cyp143 IV.F - Cytochrome P450 enzymes Rv1786 - 41.6 13.5 33.4 57.2 37.1 66.6 13.1929939149774 0.651129924302456 0.626628507316407 1.03910038675224 0.298758051111153 NA Probable ferredoxin I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1787 PPE25 18.5 9.9 9.2 17.6 8.9 9.6 20.7198783286943 -0.187105408322833 0.494019258860993 -0.378741121862783 0.704880113463077 NA PPE family protein PPE25 IV.C.2 - PPE family Rv1788 PE18 39.9 23.7 13.2 18 19.3 39.9 11.9753956643017 -0.191337385232076 0.656054732460987 -0.291648510047832 0.770555381358506 NA PE family protein PE18 IV.C.1.a - PE subfamily Rv1789 PPE26 168.2 106.6 90.2 132.3 98.4 100.2 220.19000196287 -0.318152167684795 0.214983456288706 -1.47989139805037 0.138902231664253 0.682181933169668 PPE family protein PPE26 IV.C.2 - PPE family Rv1790 PPE27 10.2 6 6.1 4 8.2 11.2 13.0101291253979 -0.294359032601192 0.649481047078067 -0.453221897583427 0.650388966001615 NA PPE family protein PPE27 IV.C.2 - PPE family Rv1791 PE19 296.4 227.3 241.9 243.9 347.5 323.1 138.720166333129 0.02412550581973 0.289353179559014 0.0833773655312801 0.933551485524772 0.998010361628995 PE family protein PE19 IV.C.1.a - PE subfamily Rv1793 esxN 664.1 412.2 356.6 504.4 621.2 507.3 233.813170382968 0.00411519207123259 0.218513819380565 0.0188326398893131 0.984974615569728 0.999019127881181 Putative ESAT-6 like protein EsxN (ESAT-6 like protein 5) V - Conserved hypotheticals Rv1794 - 409.5 369.1 255.6 352.2 502.3 415.7 565.549330659382 0.0922309896631431 0.229457676445356 0.401952077140934 0.68771929543357 0.942913432418385 hypothetical protein V - Conserved hypotheticals Rv1795 eccD5 182.8 108.6 83 185.5 163.7 124.1 335.919501002443 0.180178508106448 0.190377097955738 0.946429534020624 0.343929547532495 0.857035250878272 ESX conserved component EccD5 ESX-5 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv1796 mycP5 384.4 243.6 164.3 320 359.7 283.9 814.319009764065 0.134438003357872 0.178731121567095 0.752180158548404 0.451942724014145 0.901158530199572 Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) V - Conserved hypotheticals Rv1797 eccE5 344.8 294.6 201.4 428.1 366.8 269.1 621.022679203365 0.130628657065755 0.196370449318713 0.665215451301139 0.50591269913159 0.915911629458156 ESX conserved component EccE5 ESX-5 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv1798 eccA5 227.8 191.7 119.1 264.5 256.5 236.8 634.671611182619 0.311547334097553 0.195252383768401 1.59561347259706 0.110575117701717 0.646919977351541 ESX conserved component EccA5 ESX-5 type VII secretion system protein V - Conserved hypotheticals Rv1799 lppT 27.1 8.2 14.2 31.8 24.8 26.4 6.31379525412305 0.595601229648216 0.836091302231068 0.712363862725139 0.476239487080105 NA Probable lipoprotein LppT II.C.1 - Lipoproteins(lppA-lpr0) Rv1800 PPE28 18.2 8.3 15.3 13.7 13.4 9.9 41.7609086973926 -0.418823212458562 0.391674426525146 -1.06931467590129 0.284927899812938 0.828717740149934 PPE family protein PPE28 IV.C.2 - PPE family Rv1801 PPE29 2.7 0.6 1.7 3.3 2.9 4.5 4.66784977804173 0.896553546533071 0.998511428985832 0.897890119739222 0.369244132620586 NA PPE family protein PPE29 IV.C.2 - PPE family Rv1802 PPE30 2.5 3.7 2.3 1.3 1.4 0.1 3.95635831091908 -1.92162551390862 1.16326878269069 -1.65191875042311 0.0985511151410473 NA PPE family protein PPE30 IV.C.2 - PPE family Rv1803c PE_PGRS32 10.4 8.6 6 13.4 9.3 11.1 29.4401444536164 0.302296600053553 0.415177181813843 0.728114678010162 0.466543389459793 0.901158530199572 PE-PGRS family protein PE_PGRS32 IV.C.1.b - PE_PGRS subfamily Rv1804c - 17.9 0 10.1 23.3 16.5 5.7 5.73396414674665 0.429585097309588 0.932469892285172 0.460695944033988 0.645016765377827 NA hypothetical protein V - Conserved hypotheticals Rv1805c - 3.1 2.9 0 0 3.1 0 0.804410017784987 -0.919220792467606 2.35625550168817 -0.390119319322126 0.696448317667835 NA Hypothetical protein VI - Unknowns Rv1806 PE20 4.9 14.7 3.5 0.3 15.6 0 2.94086792520629 -0.742821768117071 1.46986735175934 -0.505366533400417 0.613301420035875 NA PE family protein PE20 IV.C.1.a - PE subfamily Rv1807 PPE31 17.5 11 4.5 7.9 4.7 4.7 15.1464997780775 -1.00322902438045 0.584759512284156 -1.71562668636495 0.0862303909377709 NA PPE family protein PPE31 IV.C.2 - PPE family Rv1808 PPE32 14.8 8.3 6.6 14.1 13.8 4.2 19.0861782767767 0.031918174772964 0.509559321733811 0.0626387810242783 0.95005414724543 NA PPE family protein PPE32 IV.C.2 - PPE family Rv1809 PPE33 25.1 24.5 9.7 16.4 18 10.9 38.9885300142569 -0.540146793223695 0.392965892209256 -1.37453861501055 0.169274530744928 0.725811798555406 PPE family protein PPE33 IV.C.2 - PPE family Rv1810 - 260.4 144.7 121.7 170.8 205.8 111.1 94.9562956701313 -0.27423132138457 0.272475026900112 -1.00644570808723 0.314201215676231 0.846375455062714 hypothetical protein V - Conserved hypotheticals Rv1811 mgtC 41.5 26.9 21.5 25.4 35.6 16.1 30.6622858239009 -0.422311424127221 0.414047452354978 -1.01995899678948 0.307747907494826 0.844880251285152 Possible Mg2+ transport P-type ATPase C MgtC III.A.2 - Cations Rv1812c - 165.4 69.7 119.9 50.9 17.8 24.8 151.811675959447 -2.12046164852611 0.344173183996073 -6.16103097837602 7.2272849884541e-10 1.9990670278064e-07 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1813c - 2645.1 1901 3372.3 412.7 35.6 535.7 1191.73249439172 -3.26865825714702 1.06545168374808 -3.06786155299736 0.00215596477785097 0.0776385081881511 hypothetical protein V - Conserved hypotheticals Rv1814 erg3 54.7 29.3 33.3 27 37.5 37.7 53.5874466516552 -0.432861511880538 0.352594265842319 -1.22764762168343 0.21957927674776 0.773070552038584 Membrane-bound C-5 sterol desaturase Erg3 (sterol-C5-desaturase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1815 - 220.4 138.9 93.6 165.1 214.8 185.8 179.093430697952 0.163937810922843 0.239988286395417 0.683107552394163 0.494538883472974 0.913636152872564 hypothetical protein V - Conserved hypotheticals Rv1816 - 90.6 31.1 49.7 72.1 73.8 77 73.7278543792302 0.190931394418944 0.318660519552253 0.599168653484969 0.549060423866271 0.92521033104044 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv1817 - 28.4 20.3 14.2 26.1 15.8 20.9 48.8535762600028 -0.154668517182979 0.346859157877236 -0.445911585928835 0.655661112843164 0.939577115195416 Possible flavoprotein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1818c PE_PGRS33 107.9 54.3 59.8 95.3 74.7 56 177.40371102108 -0.153078542862636 0.234840385312984 -0.651840792454075 0.514503883192147 0.915911629458156 PE-PGRS family protein PE_PGRS33 IV.C.1.b - PE_PGRS subfamily Rv1819c bacA 12.5 8.4 4.8 16.7 16.3 9.8 33.5609137188932 0.616307245541345 0.391639834993411 1.57365821980727 0.115566485754337 0.652035899977573 Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA III.A.6 - Efflux proteins Rv1820 ilvG 71.1 35.3 28.6 59.7 65.4 39.6 127.766111833009 0.136382702499651 0.2498196941049 0.545924543652605 0.585117806429141 0.928941202821899 Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) I.D.7 - Branched amino acid family Rv1821 secA2 373.5 232.5 191.2 258.7 309.4 230.9 1036.10414760555 -0.169271426047642 0.175664603665186 -0.963605772112577 0.335243611846168 0.853852514149632 Possible preprotein translocase ATPase SecA2 III.D - Protein and peptide secretion Rv1822 pgsA2 59.2 42.4 27.8 47.5 72.7 46.6 48.9705028234986 0.18908209408191 0.349226539445003 0.541431056134515 0.58821050616388 0.928941202821899 Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1823 - 41.1 15.3 26.7 24.8 24.5 39.4 42.7931391230871 -0.148889431480437 0.406319189570757 -0.366434653597646 0.714040765372735 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv1824 - 49.6 28.1 10.8 71.6 46.3 16.3 19.7902501998795 0.498639393856381 0.545783221110707 0.913621699182351 0.360915660394461 NA hypothetical protein II.C.5 - Other membrane proteins Rv1825 - 75.6 51.6 48.4 69.9 56.8 54.7 84.5675922572154 -0.139708201904843 0.28097550641798 -0.497225554233943 0.61903000290041 0.931582271037618 hypothetical protein VI - Unknowns Rv1826 gcvH 234 99.6 120 203.2 171.8 173.3 106.846315693897 0.0912717657726045 0.266802845743611 0.342094423761558 0.732279833774963 0.951379060695889 Probable glycine cleavage system H protein GcvH I.C.1 - General Rv1827 garA 836.7 544.1 379.5 899.8 611.4 582.3 496.201908283218 0.0892473624189909 0.19520834778574 0.457190296579675 0.647534272251066 0.939577115195416 Conserved protein with FHA domain, GarA V - Conserved hypotheticals Rv1828 - 306.2 154.9 140.5 286.3 250.1 173.4 254.266438438343 0.078515032310535 0.209508948285269 0.374757417060908 0.707840886262092 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv1829 - 344 247.3 222.2 344.4 269.5 221.9 219.78808259436 -0.162393558429008 0.222860365919327 -0.728678505750066 0.466198343845805 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1830 - 217.1 112 95.1 150 150.5 122.6 150.959014065323 -0.166450155013815 0.23084366061851 -0.72105144480831 0.470877863442098 0.902597484602108 hypothetical protein V - Conserved hypotheticals Rv1831 - 1078.9 629.6 468.3 606.6 446.2 473.9 254.789676311663 -0.659385720834058 0.211493228565881 -3.11776280169961 0.00182229399957181 0.0709924676452906 Hypothetical protein VI - Unknowns Rv1832 gcvB 329.3 186.8 198.4 142.6 150.8 148.1 897.311934889071 -0.879616535225254 0.197152242727586 -4.46161059623683 8.13459451868079e-06 0.000978273410377003 Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein) I.C.1 - General Rv1833c - 18.1 14.9 11.3 20.6 22.9 6.5 20.9686235158602 0.0060085524761342 0.497159692629946 0.0120857594958057 0.990357193840308 NA Possible haloalkane dehalogenase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1834 lipZ 19.1 13.9 5.8 11.8 13.4 6.5 15.1639638681379 -0.410239020319898 0.566491063342809 -0.724175625823853 0.468957920503474 NA Probable hydrolase V - Conserved hypotheticals Rv1835c - 65.6 33.2 30.6 53.8 45.9 52.3 140.37838254733 0.0736243092767312 0.244508778163213 0.301111108688236 0.763329770404184 0.959593750764785 hypothetical protein V - Conserved hypotheticals Rv1836c - 362.4 206.6 174 256.6 318.9 285.4 869.548457869868 0.0641132587285 0.192863116203263 0.332428823046338 0.739565477221231 0.955781054558401 hypothetical protein V - Conserved hypotheticals Rv1837c glcB 367.7 257.8 190.2 328.8 321.5 272.5 1034.34419721716 0.000543990345864104 0.168024953851267 0.00323755688304271 0.99741680786104 0.999833281786427 Malate synthase G GlcB I.B.4 - Glyoxylate bypass Rv1838c vapC13 69.3 34.3 18.5 34.1 99.7 55.8 31.5001466973586 0.476542743477697 0.480153603466043 0.992479781548485 0.320963537484517 0.849868688356633 Possible toxin VapC13 V - Conserved hypotheticals Rv1839c vapB13 67.2 51.8 25.2 67.5 105.3 40.8 24.0842242481954 0.420548369510365 0.470597467157746 0.89364775388686 0.371510387424329 NA Possible antitoxin VapB13 V - Conserved hypotheticals Rv1840c PE_PGRS34 15.9 6.6 3.7 18.2 15.4 7.1 24.8755917832122 0.568279412932308 0.485537894631127 1.17041207126385 0.241835180177517 NA PE-PGRS family protein PE_PGRS34 IV.C.1.b - PE_PGRS subfamily Rv1841c - 97.2 59.5 50.9 94.4 72.8 65.5 121.232740322012 0.0030170425603537 0.245583406844364 0.0122852052551976 0.990198070962632 0.999120249206713 hypothetical protein II.C.5 - Other membrane proteins Rv1842c - 112.5 74.5 49.7 136.4 91.3 69.5 189.900073280472 0.174377930291522 0.238506195352705 0.731125369861567 0.464702579474082 0.901158530199572 hypothetical protein II.C.5 - Other membrane proteins Rv1843c guaB1 246.1 127.5 101.9 168.4 162.8 123.5 351.400139418362 -0.20935171829093 0.192832436934552 -1.08566650724838 0.277626563752461 0.82002193939739 Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv1844c gnd1 207.7 139.1 119.3 151.7 183.2 139.1 369.500996494512 -0.168969793216701 0.201538018891338 -0.838401578750278 0.40180520307943 0.893826103932853 Probable 6-phosphogluconate dehydrogenase Gnd1 I.B.5 - Pentose phosphate pathway Rv1845c blaR 273.9 117.7 79.9 212 147.3 120.6 230.617866652753 -0.0679060142782423 0.249723913402346 -0.27192435579381 0.785680183413479 0.963989543249515 Possible sensor-transducer protein BlaR VI - Unknowns Rv1846c blaI 2004.5 1223.6 735.6 1913.4 1192.5 1132.9 891.938348699882 -0.0389073982078402 0.206658032702754 -0.188269469611194 0.850665417094621 0.975474031954732 Transcriptional repressor BlaI I.J.1 - Repressors/activators Rv1847 - 55.9 36.8 26 43.8 15.3 13.1 21.0230159985293 -0.830397252903293 0.532214483645701 -1.56026804685025 0.118696551050564 NA hypothetical protein V - Conserved hypotheticals Rv1848 ureA 84 72.5 60.1 80.1 91.1 107.4 40.7806305938739 0.12746055516857 0.386564256740233 0.32972669600496 0.741606480297402 0.955781054558401 Urease gamma subunit UreA (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1849 ureB 43.6 23.7 15.8 39.9 45.4 24.3 14.82528298273 0.215929328866727 0.557359707576796 0.387414673022404 0.698449242812142 NA Urease beta subunit UreB (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1850 ureC 50.1 40.3 43.1 49.5 44.6 35.8 125.563762395424 -0.285869800156194 0.275713496952353 -1.03683643824515 0.299812090549356 0.84163380028938 Urease alpha subunit UreC (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1851 ureF 34 22.6 19.5 26 31.4 16.5 25.0222248895015 -0.204333311421536 0.443858039966002 -0.460357350825925 0.645259742103034 NA Urease accessory protein UreF I.A.2 - Amino acids and amines Rv1852 ureG 29.7 19.7 13.6 28.4 33.1 21.6 25.2115037237448 0.237206615254679 0.437238765931703 0.542510485659295 0.587466885966142 NA Urease accessory protein UreG I.A.2 - Amino acids and amines Rv1853 ureD 35.2 32.5 17.1 40.4 18.7 16.2 26.2072499137168 -0.246158186001486 0.467988221835499 -0.525992267574658 0.598893579484124 NA Probable urease accessory protein UreD I.A.2 - Amino acids and amines Rv1854c ndh 152.1 74.7 69.5 94.4 81.9 96.2 210.187452653145 -0.279966440817014 0.227991278534874 -1.22796995839554 0.219458245576508 0.773070552038584 Probable NADH dehydrogenase Ndh I.B.6.a - aerobic Rv1855c - 161.6 101.1 83.7 116.5 118.1 70.2 160.184523175684 -0.357477338115497 0.231150824143464 -1.54651119865196 0.121981157624499 0.665646250765128 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1856c - 130.7 65.5 75.6 78.6 69.5 36 82.2012010106033 -0.727597807315107 0.300360664427759 -2.42241376280517 0.0154177846619593 0.27042333557534 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1857 modA 68.3 47.7 26.4 77 47.2 26.4 59.3368936225385 -0.0321803576516254 0.349441537103254 -0.0920908198790252 0.926625882133887 0.996131826654618 Probable molybdate-binding lipoprotein ModA III.A.4 - Anions Rv1858 modB 9.2 0 5.6 14.7 6.5 3.2 7.15619780035787 0.527986089669663 0.884263401762051 0.597091419386528 0.550446346403939 NA Probable molybdenum-transport integral membrane protein ABC transporter ModB III.A.4 - Anions Rv1859 modC 148.9 75.6 60.2 91.2 62.6 64.3 146.747896808877 -0.518373225507392 0.245019783102096 -2.11563825150965 0.0343755859538817 0.389683896509986 Probable molybdenum-transport ATP-binding protein ABC transporter ModC III.A.4 - Anions Rv1860 apa 41.8 19.7 16.6 36.8 40.7 29 46.0242236569368 0.267754277458073 0.346149057276628 0.773523058432295 0.439212887746809 0.901158530199572 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) III.A.4 - Anions Rv1861 - 40.2 13.2 7.4 22.9 15.6 8.1 7.32338683674476 -0.406550363742666 0.824021673594404 -0.493373386611644 0.621748783325637 NA Probable conserved transmembrane protein VI - Unknowns Rv1862 adhA 51.2 33.2 25.4 50.6 29.9 24 58.5001427664799 -0.213441373733229 0.331395154507541 -0.644069084384792 0.519530636726638 0.915911629458156 Probable alcohol dehydrogenase AdhA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1863c - 158.8 80.3 104.2 147.2 123.7 142.5 156.780699017369 0.0677183199752784 0.255724923573138 0.264809229499724 0.791156426534431 0.964516371138273 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv1864c - 16.7 16.2 8.3 18.1 14.7 23.5 19.2836638818531 0.315607954105922 0.511299390630098 0.617266438978118 0.537058999507523 NA hypothetical protein V - Conserved hypotheticals Rv1865c - 11.6 7.6 5 12.5 2.1 12.9 11.2081541418184 0.00611359550010008 0.69790150156339 0.00875996897327894 0.993010645393639 NA Probable short-chain type dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1866 - 7.8 5.7 3.2 3.8 11.2 3.3 20.5664289686742 -0.0692647935601434 0.541443892519674 -0.127926077876345 0.898207473437963 NA hypothetical protein V - Conserved hypotheticals Rv1867 - 26.8 22 13.1 20.7 24.4 9.5 45.4208655866372 -0.338934499698858 0.363981276940936 -0.931186632860398 0.351757031194601 0.867939293741539 hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1868 - 18.3 6.5 8.4 21 20 16.5 49.0635744133804 0.617278596754123 0.345311501711732 1.7875992942437 0.073840679434202 0.54162997700187 hypothetical protein V - Conserved hypotheticals Rv1869c - 533.1 324.2 259.5 435.2 446.4 360.7 774.388816421453 -0.0116333868131045 0.168506494266227 -0.0690382104485816 0.944959204503257 0.998153412295216 Probable reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1870c - 1802.3 1159 1118.2 1038.6 1324.6 1232 1335.33849566176 -0.367036649323989 0.205280159659025 -1.78797916921755 0.073779368654785 0.54162997700187 hypothetical protein VI - Unknowns Rv1871c - 6002.9 3233.8 2797.6 3311.8 3770.2 3323.9 2337.89062595942 -0.348549867675037 0.174433916868781 -1.99817715460253 0.0456974573917262 0.42992913995073 hypothetical protein VI - Unknowns Rv1872c lldD2 4624.9 2634.6 2406.3 2745 3130.9 2524.9 6044.31058606499 -0.365336251914024 0.165877877751179 -2.20244107814086 0.0276341669147023 0.352041830732016 Possible L-lactate dehydrogenase (cytochrome) LldD2 I.B.6.a - aerobic Rv1873 - 5.4 0 6.2 5.1 0 0 1.93765273577442 -1.22245457174298 1.66385426034195 -0.734712529144076 0.462514588172599 NA hypothetical protein VI - Unknowns Rv1874 - 34.8 25 12.5 37.9 21.5 8.2 24.2116924447175 -0.162149649176459 0.494746516621 -0.327742881918406 0.743106077467026 NA hypothetical protein VI - Unknowns Rv1875 - 75 36.6 30.7 79.3 59.3 28 34.5830603557964 0.106968699899866 0.406217268490999 0.263328785349843 0.792297174874938 0.964566014834542 hypothetical protein V - Conserved hypotheticals Rv1876 bfrA 106.8 81.6 88.3 78.8 135.2 120 80.044622328493 0.0194368651915995 0.337870729201078 0.0575275201777897 0.95412498447181 0.998153412295216 Probable bacterioferritin BfrA I.G.14 - Iron utilisation Rv1877 - 46 28.6 22.9 44.3 37.4 29.9 113.828823942454 0.0284436106069114 0.247547634877772 0.114901564787543 0.908523144790101 0.992486184237527 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv1878 glnA3 15 11.9 7.5 13 15.3 2.1 22.1707030885996 -0.322037764339615 0.514709252798823 -0.625669273650079 0.531531891009048 NA Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) I.D.1 - Glutamate family Rv1879 - 13.6 9.1 7.8 12.9 9.8 5 17.211193645228 -0.255552966464523 0.528789410003319 -0.483279282130327 0.628897448487035 NA hypothetical protein V - Conserved hypotheticals Rv1880c cyp140 185.1 116.2 101.3 150.1 148.9 111.2 286.025555553146 -0.153487865982359 0.197619964512273 -0.776681983326774 0.437346419011352 0.901158530199572 Probable cytochrome P450 140 Cyp140 IV.F - Cytochrome P450 enzymes Rv1881c lppE 315.9 196.9 122.2 142.2 236.4 208.3 137.129656746891 -0.272683407232227 0.284431884674901 -0.958694935147293 0.337712450744068 0.854445601186084 Possible conserved lipoprotein LppE II.C.1 - Lipoproteins(lppA-lpr0) Rv1882c - 148.2 87.7 54.6 114.4 137.1 98.3 139.044960763459 0.129347118588911 0.247652771199442 0.522292231831089 0.60146687702093 0.931398768888358 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1883c - 800.7 433.5 292.5 679.2 715.9 627.9 427.760751279807 0.282575311216377 0.198773908424276 1.42159156328118 0.155144855394336 0.705807023060417 hypothetical protein V - Conserved hypotheticals Rv1884c rpfC 1165.5 689.6 468 622.9 895.1 680.5 635.760703029875 -0.212521702601886 0.209708936640949 -1.01341271385946 0.310863069129992 0.845474188017264 Probable resuscitation-promoting factor RpfC V - Conserved hypotheticals Rv1885c - 51 23.2 16 54.5 56.5 47.6 37.403520020395 0.656986170712242 0.385632732302353 1.70365769209948 0.088445056517108 0.571985071522678 Chorismate mutase VI - Unknowns Rv1886c fbpB 143.2 76.8 54.3 134.4 129.2 156.7 178.297117931918 0.486983739739073 0.247312864363869 1.96909991314717 0.0489416188319298 0.446773985772666 Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1887 - 254.8 135.8 95.8 265.2 241.9 207.3 356.37023572712 0.422467691576094 0.196226878238672 2.15295526977831 0.0313221941074472 0.375387808282729 Hypothetical protein VI - Unknowns Rv1888c - 47 36.5 17.6 29 13.4 13.9 22.7068206094619 -0.949628200459003 0.501303576690912 -1.89431762431752 0.0581828630534468 NA Possible transmembrane protein VI - Unknowns Rv1888A - 9.2 4 11.2 10.3 10 0 1.73569012187353 -0.514553281859084 1.6174283708288 -0.318130491055635 0.750385955645127 NA hypothetical protein ? Rv1889c - 13.4 8.4 5.9 13.3 17.8 1.9 4.7508767340632 0.127802704542655 0.970903618986315 0.131632740926529 0.895274787335871 NA hypothetical protein V - Conserved hypotheticals Rv1890c - 9.8 8.5 1.8 9.4 7.4 6 6.44837242063383 0.140917581228966 0.848514959828502 0.166075541269712 0.868097502081794 NA Hypothetical protein VI - Unknowns Rv1891 - 227.2 132.4 94.9 147 153.2 159.4 98.7801083298113 -0.155843487612902 0.270217934893166 -0.576732583181483 0.564120117876751 0.92521033104044 hypothetical protein VI - Unknowns Rv1892 - 78.2 50.1 60.7 59.2 69.9 63.9 32.0820488022275 -0.250730632485508 0.413848637208795 -0.605851052637414 0.544613665034929 0.92521033104044 Probable membrane protein VI - Unknowns Rv1893 - 80.8 86.7 59.6 66.5 37 57.8 23.3125496969009 -0.710715296686142 0.488067747165008 -1.45618164858138 0.145342411209505 NA hypothetical protein VI - Unknowns Rv1894c - 81.5 28.9 40.1 46.1 34.8 35.1 79.3179639077749 -0.539176065876792 0.308159392133954 -1.74966617808753 0.0801759330743473 0.554416577209112 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1895 - 10.3 6.5 5.5 11.6 10.2 11.7 16.7224544210971 0.421094852310779 0.526376517545646 0.799987914115608 0.423717799557877 NA Possible dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1896c - 30.3 12.6 10.1 30.5 26.1 22.3 30.5800652009204 0.423386275165135 0.412769095385775 1.02572183794292 0.305022717739992 0.844880251285152 hypothetical protein V - Conserved hypotheticals Rv1897c - 18.4 10.5 13.7 22.9 14.9 31.6 12.7764929021319 0.449109694263795 0.626371373613671 0.717002266040328 0.473372698443208 NA hypothetical protein V - Conserved hypotheticals Rv1898 - 119.7 56.3 51.7 110.8 89.9 40.3 36.7297028996833 -0.0213454446369114 0.395446131019864 -0.0539781349784888 0.9569525845992 0.998153412295216 hypothetical protein VI - Unknowns Rv1899c lppD 299.4 115.2 133.2 233.3 144.7 112.7 278.308000807879 -0.299678568175392 0.25001065945136 -1.19866316433478 0.230658946642118 0.784923331661854 Possible lipoprotein LppD II.C.1 - Lipoproteins(lppA-lpr0) Rv1900c lipJ 104.6 66.1 34.8 92 76.9 57.1 155.0195086308 0.0137283541315611 0.247316767155151 0.0555091928843982 0.955732806381017 0.998153412295216 Probable lignin peroxidase LipJ II.B.5 - Esterases and lipases Rv1901 cinA 78.6 45.2 38.4 72.4 55.5 53.7 116.967920674022 -0.00870570326029277 0.248226569736895 -0.0350716011969237 0.972022646437611 0.998153412295216 Probable CinA-like protein CinA III.E - Adaptations and atypical conditions Rv1902c nanT 16.2 8.6 4.2 11.5 9.5 9.2 18.4103801963089 -0.110365895220658 0.516919513066214 -0.213506924058642 0.830931589009912 NA Probable sialic acid-transport integral membrane protein NanT III.A.3 - Carbohydrates, organic acids and alcohols Rv1903 - 56.4 68.1 46.4 36.7 104.1 47.7 39.7447831785234 -0.114487105601964 0.454426659554225 -0.251937475926856 0.801089392046605 0.965592404376002 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv1904 - 263.3 174.6 130.5 170.2 242 149.9 129.845677776039 -0.193380936232063 0.256254371223938 -0.754644439072103 0.450462352054848 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv1905c aao 193.8 124.1 99.6 147.5 98.8 159.2 213.971585690822 -0.209236658134413 0.249740750435004 -0.837815445697028 0.402134362607533 0.893826103932853 Probable D-amino acid oxidase Aao I.A.2 - Amino acids and amines Rv1906c - 831.5 545.4 386.3 475.4 712 711.8 463.80292885541 -0.0354762862936145 0.239630065359672 -0.148046056910123 0.882306420537911 0.980892105790941 hypothetical protein V - Conserved hypotheticals Rv1907c - 28.2 7.8 10.8 26.3 13.6 13.2 15.9750068490214 0.131267161952815 0.571626978372903 0.229637800382441 0.8183732312434 NA Hypothetical protein VI - Unknowns Rv1908c katG 112.2 60.2 48.2 101.3 82.5 65.8 273.335646792418 0.0327252826155577 0.202839831430584 0.161335583769487 0.871829098551983 0.977891032682394 Catalase-peroxidase-peroxynitritase T KatG III.F - Detoxification Rv1909c furA 44.1 21.7 33.9 41.8 25.9 58.6 27.180065051696 0.0843417590758566 0.472465519278578 0.178514104488812 0.858319245319922 0.975793048425672 Ferric uptake regulation protein FurA (fur) I.J.1 - Repressors/activators Rv1910c - 48 33.6 23.4 25 42.8 44 34.4184558789386 -0.131998376101853 0.4225131991919 -0.312412431976833 0.754727103514287 0.959593750764785 Probable exported protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1911c lppC 152.5 103.5 57.6 139.5 106.8 129.6 109.938441740662 0.121645807671213 0.268812091070186 0.452531012228359 0.650886485121715 0.939577115195416 Probable lipoprotein LppC II.C.1 - Lipoproteins(lppA-lpr0) Rv1912c fadB5 20.6 17.2 8 19.8 17.3 23.5 27.5048787062442 0.220118364079067 0.437429593919332 0.503208669781177 0.6148175699605 0.931582271037618 Possible oxidoreductase FadB5 I.A.3 - Fatty acids Rv1913 - 10.7 3.9 8.5 15 11.1 3.8 9.49440231376204 0.226903187733517 0.727717772179936 0.311801080594488 0.755191702764901 NA hypothetical protein VI - Unknowns Rv1914c - 28.1 36.2 12.7 35.8 36.6 13.4 17.26655992493 0.0445559755752658 0.555761465002752 0.0801710416807058 0.936101221397968 NA hypothetical protein VI - Unknowns Rv1915 aceAa 170.3 87.3 71.8 121 148.5 97.2 201.086539503064 -0.00147133668957471 0.224421766258285 -0.00655612293809932 0.994769008202726 0.999833281786427 Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) I.B.4 - Glyoxylate bypass Rv1916 aceAb 119.6 80.5 80.8 85.2 70.4 83.6 170.77081420446 -0.449243012317529 0.245346502410525 -1.83105529487367 0.0670922902353359 0.519824299134283 Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) I.B.4 - Glyoxylate bypass Rv1917c PPE34 3 0.4 1.9 1.8 6.4 5.2 21.303709524233 1.08053997067805 0.618203501986134 1.74787099588816 0.0804863681979698 NA PPE family protein PPE34 IV.C.2 - PPE family Rv1918c PPE35 24.2 23.7 15.9 14.1 31.7 28.2 112.141835029624 -6.07757011258337e-05 0.343198017320323 -0.000177086399275753 0.999858705496828 0.999866616390442 PPE family protein PPE35 IV.C.2 - PPE family Rv1919c - 159.4 105.3 89.9 207.3 144.9 173.7 108.585692769255 0.385459952312007 0.264069060291237 1.4596937327186 0.144374265131938 0.690135194188255 hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1920 - 30.6 11.3 14.8 18.8 19.2 10.9 23.2391738598748 -0.381099359089677 0.468168628290664 -0.814021564155448 0.415632597527651 NA Probable membrane protein II.C.5 - Other membrane proteins Rv1921c lppF 5 2.6 4.1 1.3 7.9 0.8 7.1050101877878 -0.616628026656043 0.904876501188353 -0.681449928079953 0.495586839774245 NA Probable conserved lipoprotein LppF II.C.1 - Lipoproteins(lppA-lpr0) Rv1922 - 35.8 28.4 25.3 25.6 28.8 21.6 50.3076404059174 -0.433462749141136 0.344217245545637 -1.25927086672845 0.207932512312481 0.770341510876847 Probable conserved lipoprotein II.C.3 - Murein sacculus and peptidoglycan Rv1923 lipD 127.1 66.5 74.4 97.1 80.9 92.8 194.592420894683 -0.176708950923701 0.235141132889982 -0.751501656693896 0.4523508041132 0.901158530199572 Probable lipase LipD II.B.5 - Esterases and lipases Rv1924c - 46.7 4.5 11.4 38 34.3 9.6 12.5267778711345 0.318423899816124 0.706472799263017 0.450723510018078 0.652188835799615 NA hypothetical protein VI - Unknowns Rv1925 fadD31 1855.5 1170 826.6 1152.1 1651.6 1247.7 3920.95368662721 -0.0677251354782819 0.192960541449894 -0.350979194862323 0.725603956838228 0.949890877982223 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) I.A.3 - Fatty acids Rv1926c mpt63 35.7 16 15.3 31.5 50.2 38.4 22.5801529289481 0.604054198721053 0.477674903208361 1.2645717718554 0.206024877383698 NA Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) VI - Unknowns Rv1927 - 335.4 200.1 224.1 200.5 273.7 159.2 293.080010719368 -0.480602525605325 0.234181522140326 -2.05226493197588 0.0401439221133475 0.409898801332397 hypothetical protein VI - Unknowns Rv1928c - 13.2 4.3 7 10.2 8.4 10.8 10.1361462420902 -0.0794207864992838 0.669970632237934 -0.118543683376077 0.905636884754144 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1929c - 168.7 42.8 47.6 117.2 78.5 70.2 84.2921663371917 -0.0437410223481954 0.34118201551182 -0.128204361189958 0.897987248823044 0.98854987613174 hypothetical protein VI - Unknowns Rv1930c - 3.8 0 0 1.1 3.9 10.5 2.24060456329653 1.42396512270174 1.64272310115273 0.86683210438967 0.386034008845787 NA hypothetical protein V - Conserved hypotheticals Rv1931c - 9.6 3.3 2.1 14.4 6.6 10.2 8.19693356302634 0.911287730701174 0.777087328807348 1.17269668017852 0.240917463203328 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1932 tpx 437.8 265.8 155.2 386.1 364.8 269 242.604982968898 0.114346345337655 0.216744088871759 0.527563846990589 0.597802091243589 0.930022694368295 Probable thiol peroxidase Tpx III.F - Detoxification Rv1933c fadE18 2.1 3.2 3.9 3 0 2.6 4.26821690541927 -1.00123562072837 1.11333324917347 -0.899313499773474 0.368485698717923 NA Probable acyl-CoA dehydrogenase FadE18 I.A.3 - Fatty acids Rv1934c fadE17 1.3 0 0 0.5 3 4.6 2.70872267082949 2.05158371301607 1.54026046451559 1.33197193609802 0.182869410585632 NA Probable acyl-CoA dehydrogenase FadE17 I.A.3 - Fatty acids Rv1935c echA13 2 0 2.2 2.2 1.8 3 2.36079208523425 0.0567968274657572 1.36346034825245 0.0416563837287632 0.966772624499466 NA Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1936 - 6 0.1 0.8 5 5 12.7 8.11342837666364 1.54417689233952 0.910721510914291 1.69555333198322 0.0899705021269345 NA Possible monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1937 - 6.4 6.1 3.7 7.2 5.7 5.6 22.8525420661048 0.0423134032364365 0.464467626829666 0.091100866437682 0.92741244418977 NA Possible oxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1938 ephB 6.9 3.2 4 5.2 7.7 0 7.06782895217865 -0.261871004118549 0.82081786880726 -0.3190366755771 0.74969870173386 NA Probable epoxide hydrolase EphB (epoxide hydratase) III.F - Detoxification Rv1939 - 8.7 6.4 4.2 9.6 3.8 6.3 4.47650276908052 -0.368711786262271 0.997078772507204 -0.369792032915441 0.711537451935354 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1940 ribA1 7.2 3.5 3.8 7 3.5 5.4 8.00604262835667 -0.0377039200211078 0.745870323810648 -0.0505502348296668 0.959683918938529 NA Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) I.G.9 - Riboflavin Rv1941 - 18.2 8.5 7.6 21.9 23.1 6.8 16.6107061924003 0.461895233139581 0.54416829136041 0.848809532773129 0.395987284863962 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1942c mazF5 435.4 244 222.8 385.5 311.2 290.4 165.03172261412 -0.0389979113891931 0.225512390141199 -0.172930238399653 0.862706262909086 0.976768531807831 Possible toxin MazF5 V - Conserved hypotheticals Rv1943c mazE5 234.8 137.1 122.5 136.3 229.4 247.7 113.085409335371 0.126994937828479 0.310509636271012 0.40898871723787 0.682547941177834 0.942913432418385 Possible antitoxin MazE5 V - Conserved hypotheticals Rv1944c - 24.1 7.7 15.3 23.7 26.2 12.4 16.6649377271553 0.202751322865069 0.547181666261461 0.370537493060281 0.71098204596565 NA hypothetical protein VI - Unknowns Rv1945 - 25.3 10.8 8.5 26.1 24.9 12.8 37.1775617812438 0.371484710874969 0.38931207383929 0.954208039867575 0.339978345779548 0.855368447926409 hypothetical protein IV.B.2 - REP13E12 family Rv1946c lppG 2.2 0.3 0 4 2.1 0 0.5511163388768 0.768197912346718 2.84549026355448 0.269970318361629 0.787183088531432 NA Possible lipoprotein II.C.1 - Lipoproteins(lppA-lpr0) Rv1947 - 77.1 59.2 33.3 108.6 52.3 51.1 39.8739101724124 0.223369623551697 0.392122445098866 0.569642534732688 0.568920173115963 0.92521033104044 Hypothetical protein VI - Unknowns Rv1948c - 20 20 15.3 12.5 20.8 26.4 10.5665279753654 -0.197242950401115 0.685496025355183 -0.287737555150543 0.773547640298229 NA Hypothetical protein VI - Unknowns Rv1949c - 11.1 11 8.4 7.1 12.3 3.8 13.7408383975687 -0.638744935889219 0.606643831807294 -1.05291589957536 0.292379538375886 NA hypothetical protein V - Conserved hypotheticals Rv1950c - 103.6 101.5 63 84.1 97.8 84.3 27.0091696761875 -0.219226810537952 0.438731842293655 -0.499682925661041 0.61729835690832 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv1951c - 10.9 2.9 13.2 10.5 7.1 19.1 4.64709357771936 0.00961083169239106 1.06026221861631 0.00906457999129085 0.992767610618409 NA hypothetical protein V - Conserved hypotheticals Rv1952 vapB14 74.5 36.3 39.2 48.8 32.6 12.9 13.2907054830808 -0.823128628052575 0.619958320704107 -1.32771607471567 0.184271921120011 NA Possible antitoxin VapB14 V - Conserved hypotheticals Rv1953 vapC14 47.5 63.9 27.2 52.1 58.5 12.2 21.5874658283445 -0.316304085958778 0.52940198118355 -0.59747431479504 0.550190750652916 NA Possible toxin VapC14 V - Conserved hypotheticals Rv1954c - 1.3 1.6 0.1 0.2 3.9 5.6 0.90798053282255 1.28490448497062 2.32752815170486 0.552046807266096 0.580916284515745 NA Hypothetical protein VI - Unknowns Rv1954A - 226.8 146.8 100.6 173.1 145.1 122.1 72.9039731851104 -0.271300233124023 0.288946956592432 -0.938927463792946 0.347767987489569 0.862969601311263 Hypothetical protein ? Rv1955 higB 30 15.1 24.1 24.2 36.7 28.6 15.7784525679597 0.0857872494475566 0.562970431605484 0.152383224111625 0.878884687775007 NA Possible toxin HigB VI - Unknowns Rv1956 higA 17.8 8.7 5.2 20.1 9 15.7 8.16856375686864 0.440701931639343 0.757827019996777 0.581533674586079 0.560880829442635 NA Possible antitoxin HigA I.J.1 - Repressors/activators Rv1957 - 28.5 18 27.1 10.2 31.7 27 21.2919967880293 -0.495022776783634 0.566627815755832 -0.873629502503891 0.382320054155391 NA Hypothetical protein VI - Unknowns Rv1958c - 15.8 14 8.5 7.3 19.1 20.7 13.8345063323136 -0.0213374133595627 0.634740899766288 -0.0336159421386256 0.973183409464808 NA Hypothetical protein VI - Unknowns Rv1959c parE1 88.9 56.1 30.3 100.2 68.9 57.7 30.6632753587048 0.246020689296364 0.411966689558577 0.597185878207716 0.550383286486235 0.92521033104044 Possible toxin ParE1 V - Conserved hypotheticals Rv1960c parD1 77.8 71.5 13.1 69.7 51.8 45.7 20.6574139703251 -0.0865544787493191 0.531006783684298 -0.163000702455769 0.870517881588821 NA Possible antitoxin ParD1 VI - Unknowns Rv1961 - 6.5 0 4.3 5.7 12.4 5.7 3.84900063801519 0.647551171467566 1.09406494245647 0.591876356090561 0.553933387642226 NA Hypothetical protein VI - Unknowns Rv1962c vapC35 33.8 22.1 13.8 20.1 21.6 16.5 13.1383949495628 -0.430995226566732 0.589345990508335 -0.731311035466587 0.464589191441839 NA Possible toxin VapC35 Contains PIN domain V - Conserved hypotheticals Rv1962A vapB35 36.8 42 9.6 20.2 30.2 20.6 11.2602938403483 -0.539860316580658 0.675884492466722 -0.798746416877199 0.424437466174336 NA Possible antitoxin VapB35 ? Rv1963c mce3R 14.2 10.3 1.8 11.6 10.2 8.1 16.7846528136334 0.0671891752724757 0.577054158942932 0.116434782127825 0.907307970698416 NA Probable transcriptional repressor (probably TetR-family) Mce3R I.J.1 - Repressors/activators Rv1964 yrbE3A 5.5 3.6 4.2 6.1 13 2.8 6.78190718997646 0.535318694853922 0.831201334104485 0.644030119887453 0.519555902726406 NA Conserved hypothetical integral membrane protein YrbE3A IV.A - Virulence Rv1965 yrbE3B 2.3 0 0 5.4 6.9 0.6 2.66367880841502 2.12211203583846 1.48023230120833 1.43363446001425 0.151676604269713 NA Conserved hypothetical integral membrane protein YrbE3B IV.A - Virulence Rv1966 mce3A 2.1 2.7 1.7 4 5.8 4.4 6.54261442364338 0.980417242734059 0.834042420326 1.17550045278374 0.239794556135611 NA Mce-family protein Mce3A IV.A - Virulence Rv1967 mce3B 1.8 3.4 1 5.2 2.2 5 4.84548083459516 1.19107748332095 0.994921788835375 1.19715689885051 0.231245405867528 NA Mce-family protein Mce3B IV.A - Virulence Rv1968 mce3C 1.6 0 0.8 1 2.7 0.4 1.66777077464369 0.489808819955323 1.63837172212726 0.298960738482081 0.764970002429262 NA Mce-family protein Mce3C IV.A - Virulence Rv1969 mce3D 2.2 1.4 2.6 2.9 1.5 2.2 3.76872979769207 -0.289803862460588 1.09766157967129 -0.264019318729707 0.791765032572546 NA Mce-family protein Mce3D IV.A - Virulence Rv1970 lprM 8.4 3 3.7 3.1 3.3 5 7.47185721479448 -0.736283108263128 0.792570579222675 -0.92898112491792 0.352898868288109 NA Possible Mce-family lipoprotein LprM (Mce-family lipoprotein Mce3E) II.C.1 - Lipoproteins(lppA-lpr0) Rv1971 mce3F 6.4 3.7 6 5.9 8.4 3.2 11.5050973926403 -0.101452149142057 0.653191532717056 -0.155317612155887 0.876570931608117 NA Mce-family protein Mce3F IV.A - Virulence Rv1972 - 5.2 5.9 0.5 7.3 3.1 0 2.72570167180361 -0.100980991762493 1.35873811164265 -0.0743196874344029 0.94075601204366 NA Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv1973 - 4 0 9.1 3.4 0.4 0 2.31774344510854 -1.74707794716059 1.607893430715 -1.08656327203458 0.27722986408806 NA Possible conserved Mce associated membrane protein V - Conserved hypotheticals Rv1974 - 7.1 0 2.5 4.4 8.9 0 1.95093840790117 0.423389264010254 1.52141926437449 0.278285725653884 0.780793032794792 NA Probable conserved membrane protein V - Conserved hypotheticals Rv1975 - 1.5 0 0 0.3 6.6 0 1.24984170359972 1.79640246661182 2.20257550661284 0.815591774819271 0.414733655336746 NA hypothetical protein VI - Unknowns Rv1976c - 60.6 42.3 40.1 62.2 33.1 35.8 29.6117101157598 -0.28150341274089 0.4284168260924 -0.657078330252547 0.511130551673241 0.915911629458156 hypothetical protein VI - Unknowns Rv1977 - 47.2 17.8 25.1 48.1 33.6 25.2 53.2163080485322 0.0742291769573421 0.346222685399421 0.214397207599806 0.830237319054113 0.968638603196576 hypothetical protein II.B.3 - Proteins, peptides and glycopeptides Rv1978 - 28.1 24.6 18.4 18.1 24 34.7 34.4400025913883 -0.146117558520482 0.432783976109484 -0.337622385731578 0.735647770410432 0.953602020109268 hypothetical protein IV.H - Miscellaneous transferases Rv1979c - 82.9 52.8 40.5 58.4 70.3 56.3 138.638709906075 -0.116215146115719 0.241130282029322 -0.481959980877005 0.629834375382345 0.93413540068838 Possible conserved permease II.C.5 - Other membrane proteins Rv1980c mpt64 244.9 166.1 164.9 118.5 198.5 164.3 200.171393071819 -0.480751587692386 0.270012806421996 -1.78047698575093 0.0749979324626595 0.54162997700187 Immunogenic protein Mpt64 (antigen Mpt64/MPB64) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1981c nrdF1 187.2 148 80.7 113.9 147.1 142.1 213.161466048914 -0.204390556261483 0.250874323119172 -0.814712935625507 0.415236647150008 0.901158530199572 Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv1982c vapC36 201.1 173.1 87.4 98 145.1 138.1 95.9606499055407 -0.458683938643262 0.310037591274796 -1.47944620765911 0.139021098139965 0.682181933169668 Possible toxin VapC36 Contains PIN domain V - Conserved hypotheticals Rv1982A vapB36 443.6 294.5 297.2 288.4 405.9 411.1 152.814344519997 -0.122204788752137 0.275677842131241 -0.44328839709199 0.657557147214635 0.939577115195416 Possible antitoxin VapB36 ? Rv1983 PE_PGRS35 20.4 20 15.5 16.9 31.1 27 59.889916087856 0.185658864766395 0.369921459735859 0.501887251685706 0.615746833259135 0.931582271037618 PE-PGRS family protein PE_PGRS35 IV.C.1.b - PE_PGRS subfamily Rv1984c cfp21 74 54.4 30.7 56.2 65.5 48.7 56.3936039552724 -0.081478667886514 0.322947365974313 -0.252297050451852 0.800811467811046 0.965592404376002 Probable cutinase precursor CFP21 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1985c - 11 9.3 7.7 16.1 11.3 4.8 13.9319915546616 0.0802141152474825 0.595202961475932 0.134767668239712 0.892795569588164 NA Probable transcriptional regulatory protein (probably LysR-family) I.J.1 - Repressors/activators Rv1986 - 26.6 12.4 10.7 17.5 15.7 23.2 16.3017050941551 -0.0230427185085114 0.546816091882398 -0.042139795903203 0.966387255788951 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv1987 - 421.1 285.2 201.1 219.2 490 484.1 243.140160018696 0.251882494993792 0.308384237915692 0.816781352692396 0.41405339051306 0.901158530199572 Possible chitinase II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1988 erm(37) 134.5 61.4 61.3 94.9 70.2 25.2 62.8095504673456 -0.55050567317755 0.349161066538174 -1.57665251351087 0.114875502462584 0.651222777732727 Probable 23S rRNA methyltransferase Erm(37) IV.H - Miscellaneous transferases Rv1989c - 84.8 36.4 33.6 65.8 63.9 51.3 48.1221112907642 0.0574593190419168 0.342621490272275 0.16770494751002 0.866815403770182 0.977876220223739 Hypothetical protein VI - Unknowns Rv1990c - 66.6 49.8 24.6 58.2 38.6 61.3 26.6667485603615 -0.0050759125677535 0.445942004155497 -0.0113824500057267 0.99091831498085 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1990A - 19.4 9.1 18 13 6 0 5.86443222437095 -1.45366780800642 0.968922045339511 -1.50029387296793 0.133538295873838 NA Possible dehydrogenase (fragment) ? Rv1991c mazF6 77.2 46.2 33.1 79.1 93.2 71.8 35.6026928156475 0.477153563785068 0.380862910874246 1.25282234148186 0.210270369020976 0.770341510876847 Toxin MazF6 V - Conserved hypotheticals Rv1991A mazE6 130 84.9 46 151.1 153.5 114 43.0544437982483 0.540995556920955 0.356026892958713 1.51953565199832 0.128627721074767 0.671582561030228 Antitoxin MazE6 ? Rv1992c ctpG 32.1 12.9 21.3 22.9 17.9 18.6 78.1533900675915 -0.35809962735165 0.315844069648312 -1.13378613614746 0.256884267810487 0.801061876847584 Probable metal cation transporter P-type ATPase G CtpG III.A.2 - Cations Rv1993c - 56.7 16.9 31.4 50.6 32.2 10 13.1847490270029 -0.369582031392512 0.645777834270223 -0.572305229104321 0.567115207769195 NA hypothetical protein V - Conserved hypotheticals Rv1994c cmtR 70.9 43.9 43.9 88.5 86.5 61.3 36.579566917559 0.366752516424583 0.375619654319988 0.976393306917186 0.328869597005111 0.853347384539607 Metal sensor transcriptional regulator CmtR (ArsR-SmtB family) I.J.1 - Repressors/activators Rv1995 - 1.6 6.4 2.5 0.7 2.4 10.1 4.71281953721666 -0.207673953974979 1.19008800057085 -0.174503023201112 0.861470155049225 NA hypothetical protein VI - Unknowns Rv1996 - 1074.7 410.4 692.4 211.4 13.5 149.6 685.133320756405 -2.71441556575796 0.996922192265936 -2.72279580775334 0.00647320534618597 0.161305279167121 Universal stress protein family protein V - Conserved hypotheticals Rv1997 ctpF 279 126 229.5 41.5 1.6 30.2 562.099090467525 -3.34704337408689 1.1483403433407 -2.91467890464409 0.00356054666752728 0.109427467582005 Probable metal cation transporter P-type ATPase A CtpF III.A.2 - Cations Rv1998c - 10 1.5 9.2 8.2 12.6 7.3 9.77748592764092 0.0681323543327284 0.723777663573719 0.0941343699338808 0.925002418332623 NA hypothetical protein V - Conserved hypotheticals Rv1999c - 1 1.3 3.2 0 2.1 0 2.68189402157349 -2.05663655001598 1.55255014820778 -1.32468284672808 0.185276364792292 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2000 - 5.8 5.3 3.3 6.7 5.2 5.3 13.3881597149988 0.0908109064902001 0.584993839326014 0.155233953565777 0.876636881647474 NA hypothetical protein VI - Unknowns Rv2001 - 16.6 11.2 13.6 5.9 24.9 9 16.2861788167304 -0.367116869256526 0.616238858166868 -0.595737942181368 0.551350306872492 NA hypothetical protein V - Conserved hypotheticals Rv2002 fabG3 23.3 18 15 26.7 25.8 10.5 24.0669135065607 -0.0140516830196258 0.464904793296611 -0.0302248615678625 0.97588772092279 NA Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) I.H.1 - Synthesis of fatty and mycolic acids Rv2003c - 271.2 93.8 191.5 35.2 8.7 16.8 150.169930828097 -3.42599191222469 0.664753979520847 -5.15377420484814 2.55295316963849e-07 4.41341779201254e-05 hypothetical protein V - Conserved hypotheticals Rv2004c - 661.6 291 713.2 97.8 23.8 74.8 841.096255919789 -3.370565479401 0.692860214220467 -4.86471211684915 1.14623520792273e-06 0.000158524329255714 hypothetical protein VI - Unknowns Rv2005c - 1267.4 598.6 939.7 264.7 51.1 126.8 827.101288734984 -2.9061227492784 0.658408992366582 -4.41385640684015 1.01545325080751e-05 0.00108028603528214 Universal stress protein family protein V - Conserved hypotheticals Rv2006 otsB1 74.4 41.2 59.7 17.9 10.7 16.3 252.398620922976 -2.20805189450731 0.283112966037544 -7.79919028581156 6.23056547685579e-15 4.30843602724578e-12 Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP) III.E - Adaptations and atypical conditions Rv2007c fdxA 5122 2259 3821.2 1224.2 59.7 684.3 1301.21571926627 -2.74079928003943 1.0406390798811 -2.63376547453186 0.00844437929921036 0.182905478971198 Ferredoxin FdxA I.B.6.c - Electron transport Rv2008c - 2 6.6 0.8 3.2 2.7 0 5.13039128040879 -0.639781764141438 1.06571289988143 -0.600332194733326 0.548284866650031 NA hypothetical protein V - Conserved hypotheticals Rv2009 vapB15 785 420.3 327.5 608.4 775.9 504.6 217.207775303063 0.15333395581053 0.223512186151253 0.686020563132818 0.49270014145978 0.912798788531648 Antitoxin VapB15 V - Conserved hypotheticals Rv2010 vapC15 587.3 405.9 273.3 503.1 643.1 453.4 302.51226384776 0.169462343608696 0.210737229045431 0.804140513644902 0.421315829110558 0.901158530199572 Toxin VapC15 V - Conserved hypotheticals Rv2011c - 4.9 4.8 2.5 2.7 12.8 0 2.89578414556548 0.290263831603796 1.28460077534351 0.225956450576 0.821235291763351 NA Conserved hypothetical protein, probable transcription repressor VI - Unknowns Rv2012 - 3.9 0 0 2.2 7.5 5.1 1.89045165839424 1.39914102934584 1.62848132457278 0.859169219955834 0.390247162367167 NA hypothetical protein VI - Unknowns Rv2013 - 0 0 0 0 0 5.9 0.505918538770106 1.75670377844812 3.22897648087044 0.544043534802879 0.586411515054753 NA Transposase IV.B.1.c - Others Rv2014 - 0.3 0 0 0 0 0 0.0224003920381287 -0.0353864558230091 4.03001480255116 -0.00878072601634317 0.992994084306394 NA Transposase IV.B.1.c - Others Rv2015c - 66.1 49 32.4 49.9 65.7 38.1 100.455147050634 -0.115679654587016 0.272348313994183 -0.424748928643952 0.671019711439713 0.940710721884994 hypothetical protein V - Conserved hypotheticals Rv2016 - 51.2 48.6 19.2 27.5 24.9 45.6 33.5367769977839 -0.517883623536703 0.4439957713225 -1.16641566651439 0.243446427397972 0.78958848015113 Hypothetical protein VI - Unknowns Rv2017 - 16.3 17.6 5.1 10.8 19.4 6.9 20.3956273798834 -0.210438353113587 0.532424205493138 -0.395245653639425 0.69266160300584 NA Transcriptional regulatory protein I.J.1 - Repressors/activators Rv2018 - 27.4 23.2 14.5 22.9 34.1 0 22.8994743134375 -0.338342674584007 0.546388554860693 -0.619234556752878 0.535761849766717 NA hypothetical protein V - Conserved hypotheticals Rv2019 - 31.1 12.4 15.6 29.4 20.3 27.2 14.4022549521167 0.100471996740121 0.567622864934094 0.177004844143808 0.859504584584887 NA hypothetical protein VI - Unknowns Rv2020c - 23.5 35 6 13.7 39 41.7 12.35018479227 0.381500295220835 0.721186512688079 0.528989780741834 0.596812539028924 NA hypothetical protein VI - Unknowns Rv2021c - 77.5 56.8 59 81.2 109.1 50.8 35.3676451869284 0.119194190395791 0.40195969404303 0.296532692611293 0.76682330391523 0.960459148175671 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv2022c - 30.7 30.9 22 36.1 33.6 43.3 32.119775294743 0.222078471907356 0.421017411863161 0.527480492848442 0.597859959392673 0.930022694368295 hypothetical protein V - Conserved hypotheticals Rv2023c - 31.2 11.3 6 23.8 22.2 14.8 9.21172948143212 0.269703304761274 0.720497116664136 0.374329471310011 0.708159208336334 NA Hypothetical protein VI - Unknowns Rv2024c - 55 40.1 21.3 57.9 65.8 58.7 120.877095572947 0.498525796655703 0.261170013818307 1.90881713167317 0.0562856860585258 0.490101810849978 hypothetical protein V - Conserved hypotheticals Rv2025c - 10.4 4.6 11.5 4.2 5.5 2.8 10.5276645786492 -1.43222509572353 0.729891608910797 -1.96224354169629 0.049734136836883 NA hypothetical protein II.C.5 - Other membrane proteins Rv2026c - 22.5 10.9 11.9 14.9 4.2 15.8 18.8162358745542 -0.576187288035333 0.546986689771005 -1.05338447682621 0.292164815774973 NA Universal stress protein family protein V - Conserved hypotheticals Rv2027c dosT 123.8 97 84.2 32.1 11.6 23.4 183.090873706148 -2.39001018805494 0.29697244887209 -8.04791891346241 8.42137105455471e-16 7.76450411229944e-13 Two component sensor histidine kinase DosT I.J.2 - Two component systems Rv2028c - 593.6 224.7 291.1 99.9 3 51.9 289.417098551711 -3.00663259164866 1.10805017470365 -2.71344444528678 0.00665877322570492 0.161324912772436 Universal stress protein family protein V - Conserved hypotheticals Rv2029c pfkB 1401.9 661.2 717.2 221.9 3.9 122.8 882.452664578697 -3.16617235072426 1.23719903121521 -2.55914551405231 0.0104929809546183 0.213002423814401 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) I.B.1 - Glycolysis Rv2030c - 4267.9 1855.7 2472.2 792.2 6.9 358.6 5570.12741607015 -3.09252929471508 1.35394741061969 -2.28408376164303 0.0223666087221259 0.309330198627001 hypothetical protein V - Conserved hypotheticals Rv2031c hspX 9301.8 4724.7 6561.7 1060.4 22.6 1170.6 2869.75717813787 -3.34808775780173 1.27736009237781 -2.62109938910746 0.00876467056197627 0.186485221341741 Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) III.B - Chaperones/Heat shock Rv2032 acg 828.8 376.7 641.4 158.4 3 94.1 605.004338766123 -3.08616646922918 1.26601353489348 -2.43770416679537 0.0147808647858458 0.266378598195246 Conserved protein Acg V - Conserved hypotheticals Rv2033c - 15.8 8.1 3.5 18.4 6.6 10.1 12.9421679806868 0.340394201206443 0.632650403506755 0.538044707344929 0.590546183913927 NA hypothetical protein VI - Unknowns Rv2034 - 17.5 6.5 3.6 11.4 16.8 9.9 4.42351631980874 0.134167510627692 1.00252445445707 0.133829663736584 0.893537269919364 NA ArsR repressor protein I.J.1 - Repressors/activators Rv2035 - 24.1 26.4 8.6 7.1 16.9 16.1 12.5127437901853 -0.894246844697571 0.67194672142705 -1.33082998425591 0.183244959471141 NA hypothetical protein VI - Unknowns Rv2036 - 21.6 20 12 7.8 12.2 9.3 14.3693694805999 -1.1625349130105 0.598213252195914 -1.94334530160119 0.0519744514018938 NA hypothetical protein IV.D - Antibiotic production and resistance Rv2037c - 30.3 22 17.5 25.1 15.2 8 30.1971891920535 -0.657056187428259 0.439185550140038 -1.4960787922525 0.134633123756265 0.681400014320852 Conserved transmembrane protein II.C.5 - Other membrane proteins Rv2038c - 20.2 18.6 15.3 13.1 21.3 8.5 28.1292522064139 -0.576505708123869 0.45190172627344 -1.27573247590347 0.202050104290051 0.761635411312287 Probable sugar-transport ATP-binding protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2039c - 14.8 4 10.8 12.7 9 9.3 13.0862810671942 -0.228932049959565 0.619162853841078 -0.369744484087421 0.711572883444252 NA Probable sugar-transport integral membrane protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2040c - 43.3 23 20.9 22.7 35.8 18.2 38.7360884049814 -0.400937110308657 0.383537141345623 -1.04536710291469 0.29585333495021 0.837161771605085 Probable sugar-transport integral membrane protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2041c - 27.1 10 15.9 21.9 16 15.2 36.4794037485895 -0.181449684599376 0.395824972135874 -0.458408886180861 0.646658708671561 0.939577115195416 Probable sugar-binding lipoprotein III.A.3 - Carbohydrates, organic acids and alcohols Rv2042c - 52.8 17.5 31.2 41 44.1 16.9 41.6180463286549 -0.197389680878921 0.40168083794056 -0.491409253901552 0.623137020466742 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv2043c pncA 170.6 100.4 87.3 135.5 125.9 71.5 102.061414581645 -0.276879052882301 0.265611532506596 -1.04242105103409 0.297216510834248 0.838023311893506 Pyrazinamidase/nicotinamidase PncA (PZase) IV.D - Antibiotic production and resistance Rv2044c - 11.2 6.1 9.3 8.3 11.1 8.9 3.88008360852934 -0.194256744963693 1.05253014369852 -0.184561692723676 0.853572834464365 NA hypothetical protein VI - Unknowns Rv2045c lipT 53.8 49.4 44.8 44.2 58.3 54.9 129.85802730111 -0.166699319387583 0.291074311346723 -0.572703646076872 0.566845368332293 0.92521033104044 Carboxylesterase LipT II.B.5 - Esterases and lipases Rv2046 lppI 20.9 27.3 5 21.8 32.3 12.9 20.4809088075707 0.24413169911259 0.545936800179021 0.447179415332572 0.654745522777465 NA Probable lipoprotein LppI II.C.1 - Lipoproteins(lppA-lpr0) Rv2047c - 54.5 36.9 22.4 60.9 34.7 34.4 163.215815690032 0.0480601227713271 0.255178337086035 0.188339352470674 0.850610638485358 0.975474031954732 hypothetical protein V - Conserved hypotheticals Rv2048c pks12 77.9 61.9 50.2 116.5 63.1 71.6 1473.29717950769 0.177380655098789 0.21820287718166 0.812916206192434 0.416266102169145 0.901158530199572 Polyketide synthase Pks12 I.I - Polyketide and non-ribosomal peptide synthesis Rv2049c - 68.8 60.8 23 55.3 55.3 90.6 21.2350962723676 0.223020575584794 0.51164822379458 0.435886543161995 0.662919049057812 NA hypothetical protein VI - Unknowns Rv2050 - 56.8 12.4 13.5 52.5 18.3 60 17.7305953925223 0.477092528755838 0.597380021751428 0.798641587238012 0.424498266134957 NA hypothetical protein V - Conserved hypotheticals Rv2051c ppm1 71.6 55.4 37.5 63.6 57.6 52 237.713381596951 -0.104979389031536 0.211825882916487 -0.495592831178824 0.620181711671286 0.931582271037618 Polyprenol-monophosphomannose synthase Ppm1 II.C.5 - Other membrane proteins Rv2052c - 61 36.1 37.5 69.1 56.4 26.6 121.305819721178 -0.0128177494126415 0.279340133591139 -0.0458858139997973 0.963401261055955 0.998153412295216 hypothetical protein VI - Unknowns Rv2053c fxsA 65.9 27 26.4 59.4 32.9 15.6 29.6523473199839 -0.253616690121449 0.463206744573365 -0.547523742028069 0.584018963859061 0.928941202821899 Probable transmembrane protein FxsA V - Conserved hypotheticals Rv2054 - 45.9 35.4 19.3 44.7 35.5 46.6 42.5469164424433 0.16318995194132 0.36513700913131 0.446927996506194 0.654927049035709 0.939577115195416 hypothetical protein VI - Unknowns Rv2055c rpsR2 17.3 17.5 10.1 8.8 16.3 8.6 5.1095280717651 -0.805336464003456 0.937122962962742 -0.859371177350474 0.390135766217107 NA 30S ribosomal protein S18 RpsR2 II.A.1 - Ribosomal protein synthesis and modification Rv2056c rpsN2 2.9 0 4.8 6 17.8 0 2.12102904009622 1.2239989941191 1.50213138832153 0.814841500307632 0.415163042380245 NA 30S ribosomal protein S14 RpsN2 II.A.1 - Ribosomal protein synthesis and modification Rv2057c rpmG1 11.1 6.9 0.8 14.1 14.8 22.7 2.76138796501625 1.29120233332684 1.28694092979484 1.00331126583462 0.315710702155428 NA 50S ribosomal protein L33 RpmG1 II.A.1 - Ribosomal protein synthesis and modification Rv2058c rpmB2 6.6 8.6 0 14.1 10.7 20.1 3.25248155806309 1.30757716119155 1.19529373168551 1.09393793887608 0.273982198003092 NA 50S ribosomal protein L28 RpmB2 II.A.1 - Ribosomal protein synthesis and modification Rv2059 - 17.1 11 12.3 11.8 9.6 12.2 31.1176618230375 -0.494046591831718 0.418252115144772 -1.18121719877187 0.237516450637681 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2060 - 20.4 8.6 13.9 10.9 15.1 7 7.49375755598811 -0.685617662217413 0.782498110695668 -0.876190821224956 0.380926305573351 NA Possible conserved integral membrane protein V - Conserved hypotheticals Rv2061c - 133.3 65.7 83.1 97.6 88.9 118.3 64.0527549685374 -0.102201267097471 0.32854181219398 -0.311075373983538 0.755743321747389 0.959593750764785 hypothetical protein VI - Unknowns Rv2062c cobN 49.7 35.4 26.3 56.3 37.4 45.7 239.595564172902 0.150153556683244 0.225155838335872 0.666887244821319 0.504844158953119 0.915911629458156 Cobalamin biosynthesis protein CobN I.G.13 - Cobalamin Rv2063 mazE7 44.2 7.4 9.7 40.7 36 30.3 9.11369950224207 0.686481189105053 0.754827876677948 0.909453943495444 0.363110558471835 NA Antitoxin MazE7 ? Rv2063A mazF7 32.7 7.3 8.9 21.3 34.2 11.8 10.753027311402 0.29697709026828 0.703856660124679 0.421928365664216 0.673077304893182 NA Possible toxin MazF7 ? Rv2064 cobG 63.3 26.4 23 67.2 37.3 15.2 63.2822494086987 -0.0335373185680358 0.382676409000466 -0.0876388451946484 0.930163726944463 0.998010361628995 Precorrin-3B synthase CobG I.G.13 - Cobalamin Rv2065 cobH 40.8 16.7 17.1 47.9 28.2 28.6 28.5563294115588 0.347543428490239 0.429727670018714 0.808752735133635 0.418657388048355 0.901158530199572 Precorrin-8X methylmutase CobH (aka precorrin isomerase) I.G.13 - Cobalamin Rv2066 cobI 50.9 32.8 17.5 43.7 32.4 20 77.8033109512501 -0.180936231920485 0.307044735674459 -0.589282964005352 0.555671471024457 0.92521033104044 Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase I.G.13 - Cobalamin Rv2067c - 84.4 65.8 33.9 72.1 85.1 76.6 135.35717063181 0.196527954413947 0.260890434556513 0.753296895488038 0.451271523953844 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2068c blaC 136.6 85.2 49.5 116.9 112.7 85.8 140.969994972794 0.0721398627920363 0.241818233403916 0.298322677229798 0.765456897910524 0.959593750764785 Class a beta-lactamase BlaC IV.D - Antibiotic production and resistance Rv2069 sigC 147.8 108.4 67 133.8 174.8 117.5 110.113624719153 0.227673726939816 0.265414802787592 0.857803425237066 0.391001018084687 0.893826103932853 RNA polymerase sigma factor, ECF subfamily, SigC II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2070c cobK 18.2 4.5 4.5 15.8 10.3 3.3 9.62334114189908 -0.0134174369504371 0.736461286605829 -0.0182187946528389 0.985464309159777 NA Precorrin-6X reductase CobK I.G.13 - Cobalamin Rv2071c cobM 12.7 1.9 4.5 13.2 9.6 18.4 11.3833510782235 0.902146315817411 0.689846829495564 1.30774873094233 0.19095854881453 NA Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase) I.G.13 - Cobalamin Rv2072c cobL 7.8 3.3 3.2 9.2 4.7 0.7 7.79780053435148 0.0345235491888111 0.814272284131476 0.0423980403872334 0.966181390490766 NA Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL I.G.13 - Cobalamin Rv2073c - 9.1 2.3 0 6.7 7.4 3.8 4.61672633347153 0.593394547858549 1.07280829325048 0.553122632992175 0.580179439602402 NA Probable shortchain dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2074 - 400 225.7 139.7 274.4 265.5 249.8 168.016178716698 -0.0881677747620616 0.236517515234349 -0.3727748225103 0.709316043102046 0.949890877982223 Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) VI - Unknowns Rv2075c - 23.4 12.6 8.5 20.3 16.7 14.4 35.9083108246578 0.0792359949016767 0.380464562635072 0.208261169852176 0.835025048845236 0.970453481136943 Possible hypothetical exported or envelope protein VI - Unknowns Rv2076c - 122.7 49.5 46 67.6 53 69.2 26.8071541191574 -0.385977767079271 0.441195359186453 -0.874845482942067 0.381657985664357 0.893490749801147 hypothetical protein VI - Unknowns Rv2077c - 1001.3 472.3 225 521.7 571.5 419.8 796.367072060032 -0.218449051430188 0.243935967214017 -0.895518007963668 0.370510243769599 0.885048465556592 Possible conserved transmembrane protein V - Conserved hypotheticals Rv2077A - 10.8 5.7 10.7 13.9 6.4 3.2 3.42679546758883 -0.592135595805413 1.18722283781681 -0.498756911460946 0.617950646046042 NA hypothetical protein ? Rv2078 - 18.3 12 14.2 8.9 22.6 35.1 9.18785119330841 0.212572410166353 0.770521532292106 0.275881206763949 0.782639308798004 NA hypothetical protein VI - Unknowns Rv2079 - 20.6 24.8 12.5 23.7 24.5 25.2 70.1880285076058 0.147502805160955 0.333890529473835 0.44176995793621 0.658655680012873 0.939577115195416 hypothetical protein VI - Unknowns Rv2080 lppJ 29.6 38.1 29.5 30.8 55 26.9 31.8816409603976 -0.0274167958941225 0.457351314920936 -0.0599469051463472 0.952197922137284 0.998153412295216 Lipoprotein LppJ II.C.1 - Lipoproteins(lppA-lpr0) Rv2081c - 70.2 26.2 18.9 69.6 28.1 36.7 27.4439310371269 0.119425400328381 0.471576162317304 0.253247322217328 0.800077100200058 0.965592404376002 Conserved transmembrane protein VI - Unknowns Rv2082 - 43.3 35 30.5 41.8 49.3 46.6 145.171239009834 0.121281347774803 0.261207637827344 0.464310112765421 0.642425579669911 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv2083 - 71.3 54 30.7 77.7 72.1 70.7 93.805527210786 0.341689710299545 0.272109636763573 1.25570602483449 0.209222574033356 0.770341510876847 hypothetical protein V - Conserved hypotheticals Rv2084 - 72.4 52.2 41.9 85.5 96.8 78 128.992208452979 0.455594775084622 0.247678165643459 1.83946281215787 0.0658471427987054 0.514454587842348 Hypothetical protein VI - Unknowns Rv2085 - 89.8 35.4 53.5 130.8 100.6 100.4 40.4853546366536 0.701537167031244 0.373611166138974 1.87772002181083 0.0604194762475166 0.504895079458099 hypothetical protein IV.B.1.c - Others Rv2086 - 14.7 16.2 9.1 14.5 17 17.8 14.2062465817577 0.120376001277743 0.583013358040381 0.206472115291406 0.83642214423454 NA hypothetical protein IV.B.1.c - Others Rv2087 - 7.4 12.8 0 5.8 0 0 1.28142974582753 -1.05698609462785 1.95229998920757 -0.541405573155221 0.588228066671619 NA hypothetical protein IV.B.1.c - Others Rv2088 pknJ 12 7.2 4.1 13.6 14.7 16 30.6414630905671 0.744039950171423 0.416504237739731 1.78639226868171 0.0740357665522492 0.54162997700187 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2089c pepE 6.2 7.6 1.9 6 6.3 5 9.4190763697167 0.00834519141459309 0.710088899613884 0.0117523192083848 0.990623221799256 NA Dipeptidase PepE II.B.3 - Proteins, peptides and glycopeptides Rv2090 - 3.3 7.3 2.7 4.2 7.8 2.4 8.50990970622358 -0.131644983434198 0.789900442902536 -0.166660222331894 0.867637405695403 NA Probable 5'-3' exonuclease II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2091c - 462.1 309.8 285.6 277.2 407.2 329.5 414.797909465885 -0.259919006517902 0.226561350151664 -1.14723454086016 0.251284699608527 0.796128980119145 Probable membrane protein II.C.5 - Other membrane proteins Rv2092c helY 162.7 123 83.9 156.6 143.8 109.8 565.484461379671 -0.033375675571535 0.183330617071357 -0.182051836756455 0.855542045704037 0.975712312098852 ATP-dependent DNA helicase HelY II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2093c tatC 226.7 140.3 104 198.1 184.8 132.8 240.574946187085 -0.0269774814546566 0.203981372368037 -0.13225463257489 0.894782890042163 0.987617507524591 Sec-independent protein translocase transmembrane protein TatC II.C.5 - Other membrane proteins Rv2094c tatA 1037.3 629.9 583.2 878.9 867.5 804.6 324.34533387622 -0.0027174188143564 0.198741662914198 -0.0136731210482504 0.989090767739874 0.999120249206713 Sec-independent protein translocase membrane-bound protein TatA V - Conserved hypotheticals Rv2095c pafC 113.4 61.3 52.8 97.9 69.3 40.1 107.919164559567 -0.279946392572279 0.279224749105007 -1.00258445381215 0.316061399757913 0.847340730510678 Proteasome accessory factor C PafC V - Conserved hypotheticals Rv2096c pafB 142.6 71.5 63.2 117.4 92.7 56.3 141.676605321534 -0.203102831860072 0.251336266069439 -0.808092023631634 0.419037609008199 0.901158530199572 Proteasome accessory factor B PafB V - Conserved hypotheticals Rv2097c pafA 261.2 194.7 151.1 173.2 239 222.7 459.213813471806 -0.118542479002697 0.225842839143584 -0.524889252420936 0.599660181185502 0.930785668439449 Proteasome accessory factor a PafA V - Conserved hypotheticals Rv2100 - 9.4 9 6.5 16 14.5 3.4 24.9043416947459 0.300979356167968 0.487144286785725 0.617844372462807 0.536677930651665 NA hypothetical protein V - Conserved hypotheticals Rv2101 helZ 70.4 40.9 30.8 76.8 63.2 45.2 258.930154200367 0.227323422199079 0.207775181663883 1.09408361662183 0.273918307174863 0.813810996397069 Probable helicase HelZ II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2102 - 65.5 44.2 30.5 58.7 64.1 54.1 59.5610985860295 0.148363862552211 0.310431081022723 0.477928505301155 0.632701092015774 0.93413540068838 hypothetical protein V - Conserved hypotheticals Rv2103c vapC37 179.6 136 69.8 159.9 139.4 151.3 95.8418856515701 0.0661925809633943 0.278189663455074 0.237940476081291 0.811927261511701 0.966073477417693 Possible toxin VapC37 Contains PIN domain V - Conserved hypotheticals Rv2104c vapB37 300 147.9 133.3 246.2 303.2 160.9 85.2387649522487 0.128507231699936 0.28479334849131 0.451229750907815 0.651823969384388 0.939577115195416 Possible antitoxin VapB37 V - Conserved hypotheticals Rv2105 - 13.9 10.5 2.5 11.4 7.9 0 3.49342142462816 -0.418304148171933 1.14707644195738 -0.364669810024286 0.715357897019435 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2106 - 8.1 5.2 4 3.1 9.9 0 7.5971057658288 -0.69477560268704 0.82135484553159 -0.84588969854725 0.397614279781343 NA Probable transposase IV.B.1.a - IS6110 Rv2107 PE22 27.1 20.8 11.9 9.7 10.8 14.6 7.02531232858749 -1.28995989255852 0.830782558667684 -1.55270459050948 0.120493725141685 NA PE family protein PE22 IV.C.1.a - PE subfamily Rv2108 PPE36 30.2 21.8 16 9.7 19 8.4 20.3148554882546 -1.16881395745555 0.516227957292383 -2.26414308048326 0.0235653160603982 NA PPE family protein PPE36 IV.C.2 - PPE family Rv2109c prcA 455.4 255.6 236.7 325.8 296.2 266.3 366.555206059777 -0.26420940450822 0.18977857707401 -1.39219825852727 0.163862369990688 0.722148552452466 Proteasome alpha subunit PrcA; assembles with beta subunit PrcB II.B.3 - Proteins, peptides and glycopeptides Rv2110c prcB 744.7 416.8 428.2 512 562.2 442.4 732.134499736828 -0.252561428724587 0.18530544387637 -1.36294662175758 0.172899333893554 0.730136729083316 Proteasome beta subunit PrcB; assembles with alpha subunit PrcA II.B.3 - Proteins, peptides and glycopeptides Rv2111c pup 1919.1 1155.9 1051.4 2035.5 2194.1 1675.2 518.1058313841 0.337119492866382 0.182649643373293 1.84571667724196 0.0649333544013511 0.514454587842348 Prokaryotic ubiquitin-like protein Pup V - Conserved hypotheticals Rv2112c dop 201.7 148.1 112.7 164.8 166 145.6 421.184685532664 -0.146606998587189 0.19154614799094 -0.765387349862674 0.444040923482408 0.901158530199572 Deamidase of pup Dop V - Conserved hypotheticals Rv2113 - 18.1 13 9.9 22 18.8 13 29.7162354371447 0.243385277872469 0.408770747359838 0.595407766931568 0.55157093502253 0.92521033104044 Probable integral membrane protein II.C.5 - Other membrane proteins Rv2114 - 40.8 23.6 23.9 26.6 54.9 47.1 35.9913359951732 0.294058520983697 0.423397011085552 0.69452195760607 0.48735493553647 0.909299509995111 hypothetical protein VI - Unknowns Rv2115c mpa 569.5 425.2 300.5 515.7 572.6 418.4 1369.99983590956 0.0313465404301123 0.17423326235491 0.17991134417411 0.857222169159101 0.975751654277397 Mycobacterial proteasome ATPase Mpa III.C - Cell division Rv2116 lppK 11.2 15.1 2.9 6.3 6.2 5.9 6.99351327715997 -0.783078309347034 0.850104345757669 -0.921155518442978 0.356969237934734 NA Conserved lipoprotein LppK II.C.1 - Lipoproteins(lppA-lpr0) Rv2117 - 2.2 3.1 5 5.9 8.1 9.6 2.04682751114272 1.26501771044082 1.48956423602161 0.849253546674485 0.395740223377512 NA hypothetical protein V - Conserved hypotheticals Rv2118c - 27.8 15 5.1 28.6 16.1 13.4 21.7594427766229 0.205972433485977 0.517527690210896 0.397993068548742 0.690635295123059 NA RNA methyltransferase V - Conserved hypotheticals Rv2119 - 20.3 12.8 8.1 11.9 35.1 6.8 19.909102006281 0.191171087773697 0.560834522828548 0.340868972918309 0.733202223479699 NA hypothetical protein V - Conserved hypotheticals Rv2120c - 39.1 27.3 16.6 43.2 63.6 60.6 31.264622821669 0.84236297436321 0.424563102857963 1.98407013867388 0.0472480214887712 0.437633017338973 Probable conserved integral membrane protein VI - Unknowns Rv2121c hisG 8 1.8 5 9.2 4.2 7 7.25332882936781 0.268573230322241 0.803402353968064 0.334294801347964 0.738157112944476 NA ATP phosphoribosyltransferase HisG I.D.5 - Histidine Rv2122c hisE 1.6 6.8 0 0.3 1.1 8.8 0.930666954540779 -0.362250265906559 2.32328220592283 -0.155921766620973 0.876094687863929 NA Phosphoribosyl-AMP pyrophosphatase HisE I.D.5 - Histidine Rv2123 PPE37 0.7 0 0.4 0 2.6 0 0.982182061776044 1.39840104363751 2.38291215823397 0.586845402087291 0.557307541098089 NA PPE family protein PPE37 IV.C.2 - PPE family Rv2124c metH 159.9 110.9 94.3 140.9 144 128.1 750.262192996203 -0.0145123144100223 0.181242971057108 -0.0800710467577227 0.9361807501304 0.998153412295216 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms) I.D.2 - Aspartate family Rv2125 - 151.4 56.4 63.3 128.4 81.5 71.2 124.801743466005 -0.0807327241480945 0.278986128314618 -0.289378990402887 0.772291370793287 0.962433896292784 hypothetical protein V - Conserved hypotheticals Rv2126c PE_PGRS37 8.3 3.8 2.3 8.2 3.7 5.5 5.40681670629467 0.209381352907071 0.915630020784107 0.228674626382134 0.819121817477782 NA PE-PGRS family protein PE_PGRS37 IV.C.1.b - PE_PGRS subfamily Rv2127 ansP1 166 103.1 74.5 208.6 166.5 122 321.60355368305 0.372645881418361 0.200498400227098 1.85859777931533 0.063084172117286 0.514454587842348 L-asparagine permease AnsP1 III.A.1 - Amino acids Rv2128 - 264.9 160.2 164.6 287.7 202.5 186.7 68.6286339321004 0.019307757285397 0.303782267149903 0.0635578813290952 0.949322269727586 0.998153412295216 Conserved transmembrane protein VI - Unknowns Rv2129c - 68.3 35.2 30.9 58 55.7 45.3 67.6378535649469 0.0689302167176844 0.294634014331205 0.23395199931057 0.815022243554671 0.966703055605583 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2130c mshC 183.4 108.3 101.4 122.2 129.3 131.8 260.738451424572 -0.222054223269017 0.217127939319176 -1.02268839268354 0.306455201209451 0.844880251285152 Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC II.A.3 - Aminoacyl tRNA synthases and their modification Rv2131c cysQ 360.5 218.9 172.3 332.2 273.6 176.7 324.452257088992 -0.110776818604632 0.204996757250231 -0.540383272840805 0.588932741038708 0.928941202821899 Monophosphatase CysQ I.C.5 - Sulphur metabolism Rv2132 - 128 83.9 76.5 127.6 114.6 96.3 38.1109352426435 0.0521951246409336 0.368075312173379 0.141805556946312 0.88723359462193 0.982421186038534 hypothetical protein V - Conserved hypotheticals Rv2133c - 103.7 35 45.1 84.3 82.3 63.2 84.1037719782133 0.162999802712554 0.297420734502993 0.548044516751447 0.583661336170653 0.928941202821899 hypothetical protein V - Conserved hypotheticals Rv2134c - 323.4 192.1 185.1 265.1 253.2 144.9 213.800131177568 -0.266852046238112 0.22498361324243 -1.18609547776516 0.235584596231547 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2135c - 224 134.4 105.8 190.7 143.1 132.1 174.973878266787 -0.154739096945589 0.223550472870988 -0.692188636232005 0.488818874145084 0.910063990546522 hypothetical protein V - Conserved hypotheticals Rv2136c - 285.9 191.3 139.9 208.8 196.1 181.9 267.819842580312 -0.238498707217983 0.201540152155165 -1.18338060514296 0.236658340325427 0.78958848015113 Possible conserved transmembrane protein III.A.6 - Efflux proteins Rv2137c - 2017.4 1205.9 600.5 1021.7 1298.3 1011.5 774.110330079827 -0.295009729206483 0.223775746140497 -1.31832754127546 0.187394025168119 0.739746500217031 hypothetical protein V - Conserved hypotheticals Rv2138 lppL 165.3 103.2 59 108.5 134.4 102.9 190.051320828686 -0.0581346173747619 0.237986447154112 -0.244277008501731 0.807016288749253 0.965592404376002 Probable conserved lipoprotein LppL II.C.1 - Lipoproteins(lppA-lpr0) Rv2139 pyrD 84.8 57.9 53.4 87.1 93.2 43.8 119.759928836168 -0.0113362846081845 0.269455793694665 -0.0420710367839791 0.966442069018784 0.998153412295216 Probable dihydroorotate dehydrogenase PyrD I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv2140c TB18.6 18.2 4.4 2.7 17.9 17.8 5.6 7.80351076016338 0.533429138495356 0.815267408638359 0.654299598933161 0.512918804231164 NA Conserved protein TB18.6 V - Conserved hypotheticals Rv2141c - 30.1 19 12.4 30.9 18 19.7 45.2400921939553 0.0153280199315859 0.357386218774733 0.0428892305476598 0.965789833630269 0.998153412295216 hypothetical protein I.D.2 - Aspartate family Rv2142c parE2 91 24.9 52 50.7 65.4 69.9 29.4770396029977 -0.0862909037406361 0.456736295617915 -0.188929376904224 0.850148168748757 0.975474031954732 Possible toxin ParE2 VI - Unknowns Rv2142A parD2 213 97.2 75.9 97.9 205.2 160.2 47.7172885349418 0.0891595196041854 0.393326228407727 0.226680839376319 0.820671927272265 0.967203057682185 Possible antitoxin ParD2 ? Rv2143 - 34.8 22 17.6 32.1 32 14.6 42.2981225544055 -0.0708411395493788 0.361113692453862 -0.196174061049845 0.844473929859519 0.975474031954732 hypothetical protein V - Conserved hypotheticals Rv2144c - 479.2 289.7 266.8 660.3 523.1 513.4 257.429362451887 0.528906288686625 0.206825329632954 2.5572607070191 0.010550011591675 0.213002423814401 Probable transmembrane protein II.C.5 - Other membrane proteins Rv2145c wag31 633 408.5 331.6 483.1 527.7 529.5 613.22762504848 -0.000965607577696088 0.19509226357204 -0.00494949189689179 0.996050892955513 0.999833281786427 Diviva family protein Wag31 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2146c - 201.4 96.5 119.7 218.5 177.6 177.3 76.2777614434049 0.257055135411325 0.293457443401609 0.875953707057735 0.381055200697704 0.893490749801147 Possible conserved transmembrane protein VI - Unknowns Rv2147c - 296.6 178.1 130.8 218.3 280.6 192.4 248.229523624335 0.029535982243543 0.21566151037502 0.136955278631695 0.891066144413121 0.985189043752372 hypothetical protein VI - Unknowns Rv2148c - 141.2 93.1 77.3 121.2 113.2 115.3 137.300935717055 -0.0198116119924151 0.23978039871987 -0.0826239846884257 0.934150529455285 0.998010361628995 hypothetical protein V - Conserved hypotheticals Rv2149c yfiH 163.8 74 70.1 146 118.7 110.1 133.549375146338 0.130598517300047 0.246024152623926 0.530836163470829 0.595532317529225 0.929194918847511 Conserved protein YfiH V - Conserved hypotheticals Rv2150c ftsZ 308.4 164.9 138.4 318.4 234.5 133.3 384.056860158435 0.00178758766647007 0.226705305335298 0.00788507204904718 0.993708687944366 0.999833281786427 Cell division protein FtsZ III.C - Cell division Rv2151c ftsQ 123.9 80.1 73.9 152.1 108 78.4 154.093812106657 0.101269576940672 0.247045270974737 0.409923155141178 0.681862319002753 0.942913432418385 Possible cell division protein FtsQ III.C - Cell division Rv2152c murC 125.3 88.5 68 139.8 107.2 83.6 241.209921406291 0.0537977063914258 0.213390928272829 0.252108685345064 0.80095705681921 0.965592404376002 Probable UDP-N-acetylmuramate-alanine ligase MurC II.C.3 - Murein sacculus and peptidoglycan Rv2153c murG 79.6 24.3 19.9 104.5 47.3 52.1 100.303561987753 0.635340528971098 0.3458619348694 1.83697731642832 0.0662132441329992 0.514454587842348 Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG II.C.3 - Murein sacculus and peptidoglycan Rv2154c ftsW 160.3 78.9 72.6 184.3 123.8 107.4 297.625880604742 0.260832480162533 0.215820641937481 1.20856132120157 0.226831423754838 0.780210909201606 FtsW-like protein FtsW III.C - Cell division Rv2155c murD 133.1 68 59.7 135.7 105.5 77 220.357542537851 0.137087023542578 0.219229887286061 0.625311745764392 0.531766472448241 0.922751607774049 Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD II.C.3 - Murein sacculus and peptidoglycan Rv2156c murX 139.4 84 56.8 146.6 91.5 53.2 159.272187258631 -0.0876253175729027 0.274169727276117 -0.319602453718952 0.74926971406739 0.957707961696119 Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX II.C.3 - Murein sacculus and peptidoglycan Rv2157c murF 93.7 52.1 50.6 86.2 40.2 42.4 148.628162713871 -0.384766893629242 0.278288585447223 -1.38261830973377 0.166781931851966 0.725041090026968 Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF II.C.3 - Murein sacculus and peptidoglycan Rv2158c murE 242.5 121.6 113.1 188.7 129.1 114.7 385.663101288036 -0.296560760228449 0.204740520124517 -1.44847126522922 0.147485296599804 0.695223866622759 Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE II.C.3 - Murein sacculus and peptidoglycan Rv2159c - 386.1 202.4 204 268.5 236.7 148.8 398.240970780472 -0.455415186672897 0.203968778167007 -2.23276910694641 0.0255641745127401 0.335120884844735 hypothetical protein VI - Unknowns Rv2160A - 813.2 473.2 390.4 581.8 437.8 276.8 500.772740881091 -0.542103224029853 0.205786701203482 -2.63429668127009 0.00843117819946062 0.182905478971198 hypothetical protein ? Rv2160c - 1132.6 713.7 582.9 763.7 669.4 447.1 394.139657513558 -0.543859533617198 0.192715470405595 -2.82208549460287 0.00477124558808464 0.134665972414715 hypothetical protein VI - Unknowns Rv2161c - 720.1 358.3 277.1 691 429.6 267 612.686531654438 -0.113999989362531 0.237192328434007 -0.480622582168582 0.630784762776828 0.93413540068838 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2162c PE_PGRS38 237 102.1 143.8 317.7 150.1 166.2 470.29106792341 0.196000913895149 0.263950396237345 0.742567227362314 0.457743736215832 0.901158530199572 PE-PGRS family protein PE_PGRS38 IV.C.1.b - PE_PGRS subfamily Rv2163c pbpB 62.8 36.3 29.1 69.7 88.6 71.5 191.281059834632 0.677240358506915 0.229776288082767 2.94739010782073 0.0032046863428491 0.101886924417478 Probable penicillin-binding membrane protein PbpB II.C.3 - Murein sacculus and peptidoglycan Rv2164c - 61.3 28 29.5 66 36.9 41.8 79.4053792543536 0.126090164724724 0.30342402537724 0.415557616335619 0.677733746269215 0.942913432418385 Probable conserved proline rich membrane protein VI - Unknowns Rv2165c - 51.1 25.2 29.8 57.5 49.9 34.4 77.6107461102456 0.231975776096021 0.290466278450361 0.798632382848753 0.424503604815825 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2166c - 354.3 212.8 196.5 234.7 423.2 258.4 193.012318655846 0.0711724702966428 0.262184106137129 0.271459896426437 0.786037340038712 0.963989543249515 hypothetical protein V - Conserved hypotheticals Rv2167c - 4.6 2.2 4.2 3.4 1.3 3.9 5.13225568711934 -0.640761404168955 0.950438030504614 -0.674174836868383 0.500200165410025 NA Probable transposase IV.B.1.a - IS6110 Rv2168c - 10.2 10.4 2.1 16.7 30 8.2 5.75320709653078 1.07951276413831 0.904287098252396 1.19377216176649 0.232567103985774 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2169c - 205.7 126.5 62 179.6 132.7 114 85.6547950362196 0.00313145141208166 0.294865600874718 0.0106199278681278 0.991526682791649 0.999476240744061 Probable conserved transmembrane protein VI - Unknowns Rv2170 - 10.9 9.5 2.3 8 7 5.4 6.37520486451543 -0.300744702803129 0.841823273870798 -0.357253965455565 0.720901689231521 NA GCN5-related N-acetyltransferase VI - Unknowns Rv2171 lppM 27.4 21.6 11 23 25.1 4.8 19.2293269319647 -0.328386414824359 0.541579827580169 -0.606349051610029 0.544282992680876 NA Probable conserved lipoprotein LppM II.C.1 - Lipoproteins(lppA-lpr0) Rv2172c - 355.6 279.1 155.1 248.3 272 254.6 379.637546230923 -0.187442535132136 0.215355171714014 -0.870387897538184 0.384088458293389 0.893826103932853 hypothetical protein VI - Unknowns Rv2173 idsA2 63 32.5 22.8 58.8 48.3 36.8 71.5834761676504 0.158825962549159 0.297231269880177 0.534351458422211 0.59309839630639 0.928941202821899 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv2174 mptA 43.4 29 21.7 41.4 29.4 28.7 79.5852587990222 -0.0709779829389146 0.283134296233292 -0.250686631337772 0.802056397355524 0.965592404376002 Alpha(1->6)mannosyltransferase Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2175c - 36.6 11.9 18.7 27.6 26.6 28.3 16.8376375273502 0.0597023788256764 0.534241067542367 0.11175175862148 0.911020238874375 NA Conserved regulatory protein I.J.1 - Repressors/activators Rv2176 pknL 26 21.8 14.2 25.4 14.6 23.4 40.1317581968251 -0.156850465234508 0.382973929656398 -0.40955911901166 0.682129390889972 0.942913432418385 Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2177c - 25.1 10.1 13 17.5 13 13.1 15.6788253466529 -0.335554327704382 0.550476349714226 -0.609570834203108 0.54214613679743 NA Possible transposase IV.B.1.c - Others Rv2178c aroG 337 195.8 125.2 319.5 348.1 211.5 552.817717859817 0.280472263484784 0.198117505558686 1.4156864265672 0.156867334203007 0.70782226167295 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phenylalanine-repressible) I.D.4 - Aromatic amino acid family Rv2179c - 9.7 14.9 16.7 9.7 4.7 0 8.2544050685354 -1.63206831282568 0.871588241861729 -1.87252217783429 0.0611343965768474 NA hypothetical protein VI - Unknowns Rv2180c - 12.2 4.6 6.6 10 8.3 3.2 9.83958465197494 -0.387415158005911 0.693146764797554 -0.558922262472165 0.576214775123845 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2181 - 91.6 54.7 47.7 95.2 89.1 61.5 148.40878821328 0.172226052408973 0.230982583561678 0.745623543356826 0.455894856734746 0.901158530199572 Alpha(1->2)mannosyltransferase II.C.5 - Other membrane proteins Rv2182c - 242.6 122.4 121.7 189.7 234.5 154.5 208.777684166289 0.0734908955940162 0.224285427592699 0.327666832316344 0.743163584036705 0.956095160416489 1-acylglycerol-3-phosphate O-acyltransferase V - Conserved hypotheticals Rv2183c - 112 47.6 59.1 99.9 85 84.8 50.5631117637263 0.103405204012743 0.336873888163147 0.306955236502818 0.758877444496424 0.959593750764785 hypothetical protein VI - Unknowns Rv2184c - 49.1 24.5 26.4 70 47.7 53.8 81.1366934739334 0.611200738303929 0.288420308957798 2.11913211144004 0.0340793036239757 0.388280173938367 hypothetical protein V - Conserved hypotheticals Rv2185c TB16.3 126.2 40 92 141.2 144.2 89.1 72.1215835511881 0.308100592659489 0.345631706313914 0.891412989697369 0.372707651584225 0.88686061881849 Conserved protein TB16.3 V - Conserved hypotheticals Rv2186c - 91.8 74.3 38 94.8 82.9 105 50.5329387382398 0.30708513043747 0.347561259486697 0.883542460661454 0.376943251712463 0.891834044433142 hypothetical protein V - Conserved hypotheticals Rv2187 fadD15 55.3 33.9 29.4 43.1 38.8 38.2 115.133097121137 -0.166051952510389 0.248930315088148 -0.667061994645326 0.504732534912 0.915911629458156 Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2188c pimB 15 7.4 10.9 7.2 9.1 8.2 17.8176374584723 -0.751681032862456 0.533302911022575 -1.40948233607267 0.158692592953834 NA Mannosyltransferase PimB V - Conserved hypotheticals Rv2189c - 91.5 55.9 38.3 132.5 124.5 68.8 101.172633914146 0.663109688025542 0.269635323310163 2.45928344953069 0.0139214655359987 0.260180903193056 hypothetical protein VI - Unknowns Rv2190c - 403.5 283.1 188.9 479.3 504.4 426.7 697.462555943961 0.526931008752507 0.180026503694381 2.92696351892187 0.00342289028288814 0.106378814859198 hypothetical protein IV.A - Virulence Rv2191 - 9.9 4.9 6 9.8 9.5 8.8 24.7729707358132 0.244100856676632 0.442824395880415 0.551236243864377 0.581471737520445 NA hypothetical protein II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2192c trpD 79.9 46.4 49.5 94.4 47.4 45.8 107.551287295231 -0.0849955489827219 0.294857975004798 -0.288259284766975 0.773148270991528 0.962433896292784 Probable anthranilate phosphoribosyltransferase TrpD I.D.4 - Aromatic amino acid family Rv2193 ctaE 1293.5 852.8 619 740.3 1070 851.6 891.082010880994 -0.211584114942956 0.205021452085698 -1.03200963992058 0.30206760160288 0.842296632810805 Probable cytochrome C oxidase (subunit III) CtaE I.B.6.a - aerobic Rv2194 qcrC 1395.7 951.3 756.5 783.7 961.2 722.7 1272.8336461142 -0.514072181025758 0.17937926883452 -2.86583942707447 0.00415905144660019 0.121094066329433 Probable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) I.B.6.a - aerobic Rv2195 qcrA 1245.1 776.6 652.8 747.9 677.7 646.6 1654.30901444924 -0.539662138283289 0.164134086663491 -3.28793457382017 0.00100925291039159 0.0489753254411078 Probable rieske iron-sulfur protein QcrA I.B.6.a - aerobic Rv2196 qcrB 1275.4 637.9 621.4 768.3 719.4 571.7 2018.57882510929 -0.456996380062376 0.165403423433802 -2.76291971819602 0.005728685501905 0.1467180009099 Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) I.B.6.a - aerobic Rv2197c - 118.9 69.9 57.6 149 70.8 107.8 96.9498702932154 0.25894848445825 0.295973135250136 0.874905366797581 0.381625398708291 0.893490749801147 Probable conserved transmembrane protein VI - Unknowns Rv2198c mmpS3 207.2 141.5 108.8 162.5 185.4 141.3 227.608643653062 -0.091249921942261 0.212276012062573 -0.429864500730131 0.667294209916708 0.940354944889996 Probable conserved membrane protein MmpS3 II.C.4 - Conserved membrane proteins Rv2199c - 600.7 330.4 193.4 558.4 436.7 300.1 261.171992173404 0.0860492520523949 0.232168769174255 0.370632330775766 0.710911398005834 0.949890877982223 Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2200c ctaC 778.4 675.2 437.4 626.6 745.5 779.6 1201.4050971534 0.00851627671187662 0.218129496013442 0.039042297660431 0.968856665648713 0.998153412295216 Probable transmembrane cytochrome C oxidase (subunit II) CtaC I.B.6.a - aerobic Rv2201 asnB 24.7 13.2 10.8 15.2 19.6 14.4 50.2544457570355 -0.198320800656028 0.336774512871558 -0.588883045112341 0.55593973219125 0.92521033104044 Probable asparagine synthetase AsnB I.D.2 - Aspartate family Rv2202c adoK 369.6 208.1 177.2 287.4 272.6 206.4 392.423190960827 -0.143256480560741 0.184227875775259 -0.777604800347917 0.436802030221509 0.901158530199572 Adenosine kinase I.A.1 - Carbon compounds Rv2203 - 17.1 11.8 7.5 8.4 16.7 17.2 14.2224974954773 -0.00840751348684553 0.60283055076283 -0.0139467276106139 0.988872482104768 NA Possible conserved membrane protein VI - Unknowns Rv2204c - 2572.4 1971.3 1509.5 1577.4 2045.2 1987 1138.84401823659 -0.291881157917088 0.212144424078016 -1.37586061564243 0.168864790577984 0.725798155285455 hypothetical protein V - Conserved hypotheticals Rv2205c - 39.5 19.1 12.1 29.9 28 27.5 42.9152220367045 0.137654881597147 0.364785126294776 0.37735881118659 0.705906972015415 0.949678348538248 hypothetical protein V - Conserved hypotheticals Rv2206 - 185.2 125.9 84.4 113.9 154.4 91.6 142.571934678964 -0.307224643442132 0.249959674477123 -1.22909682965782 0.219035503687538 0.773070552038584 Probable conserved transmembrane protein VI - Unknowns Rv2207 cobT 100.6 56.5 49.4 100.7 54.5 49 117.089654504979 -0.16479659840939 0.277649554228656 -0.593541735974383 0.552818660319242 0.92521033104044 Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT I.G.13 - Cobalamin Rv2208 cobS 56.6 21.8 21.5 65.1 26.7 11.1 37.6120752064323 -0.0594475569146556 0.471201363379503 -0.126161682742791 0.899603941696837 0.98854987613174 Probable cobalamin 5'-phosphate synthase CobS I.G.13 - Cobalamin Rv2209 - 32.4 18.6 12.3 18.7 18.5 16.4 46.5062733293073 -0.419898421353709 0.344645447810108 -1.21834895548965 0.223091393771056 0.774556499980442 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv2210c ilvE 134.8 89.1 81.9 121.2 139.1 96.2 196.121303767767 0.0234374067522078 0.224175236251128 0.104549490586696 0.916733295627499 0.9932884147079 Branched-chain amino acid transaminase IlvE I.D.7 - Branched amino acid family Rv2211c gcvT 45.5 43.1 19.1 58.7 36.3 39.2 72.4927082165586 0.189066101610177 0.321676422190815 0.587752438685187 0.556698472188253 0.92521033104044 Probable aminomethyltransferase GcvT (glycine cleavage system T protein) I.C.1 - General Rv2212 - 40.7 28.6 19.5 29.7 34.9 12.5 49.2134596748365 -0.364341272999773 0.352915362906633 -1.03237577984431 0.301896113598618 0.842296632810805 Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase) V - Conserved hypotheticals Rv2213 pepB 54.1 31.2 29 60.9 50.3 39.2 107.334806014675 0.229440683159842 0.254993639664075 0.899789827942784 0.368232108640331 0.883373818299354 Probable aminopeptidase PepB II.B.3 - Proteins, peptides and glycopeptides Rv2214c ephD 171.1 135 95.2 137.2 153.4 137.2 398.644372599483 -0.0977019502963599 0.205364759754802 -0.475748372861111 0.634253654331728 0.934597866696866 Possible short-chain dehydrogenase EphD III.F - Detoxification Rv2215 dlaT 355.7 215.3 166.6 228.2 248.7 205.1 628.935376054614 -0.272964040624262 0.177541955776033 -1.53746217017346 0.124180172072899 0.666956030977941 DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase I.B.3 - TCA cycle Rv2216 - 236.6 127.8 106.9 208.3 188.2 151.3 241.867970364876 0.0606028397890645 0.20332918304228 0.298052836697144 0.765662837287737 0.959593750764785 hypothetical protein V - Conserved hypotheticals Rv2217 lipB 201.7 160.5 102.4 186.7 143.3 158.7 176.971830889218 -0.102499011829842 0.234898665074235 -0.436354169136929 0.662579785610942 0.939577115195416 Probable lipoate biosynthesis protein B LipB I.G.3 - Lipoate Rv2218 lipA 214.3 95.2 100.5 133.5 131.1 146.8 203.967071500747 -0.15861720015629 0.237370697200865 -0.668225699409169 0.50398953314742 0.915911629458156 Probable lipoate biosynthesis protein A LipA I.G.3 - Lipoate Rv2219 - 274.6 126 135.2 164.6 180.8 193.9 215.478434146827 -0.158345722821931 0.238995187766424 -0.662547745424422 0.507620246364425 0.915911629458156 Probable conserved transmembrane protein VI - Unknowns Rv2219A - 38.5 15.5 19.2 65.3 20.8 20.1 18.898753260208 0.425753004611454 0.560341268081306 0.759810188653955 0.447368051805771 NA Probable conserved membrane protein ? Rv2220 glnA1 344.5 244.6 191.7 204.2 305.4 240.9 596.040115400027 -0.241421182181579 0.216951054052496 -1.11279100825738 0.265798198083617 0.80816433845196 Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) I.D.1 - Glutamate family Rv2221c glnE 69.5 43.7 31.5 87.3 42.7 52.8 256.139260084359 0.184193185378342 0.245991539935074 0.748778536964959 0.453990698123742 0.901158530199572 Glutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase) I.D.1 - Glutamate family Rv2222c glnA2 703.9 444.6 307.8 573.7 633.1 446.4 1100.05168562872 0.0278998853260267 0.171863826271874 0.162337159198885 0.871040353950231 0.977891032682394 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) I.D.1 - Glutamate family Rv2223c - 109.9 53 39.1 77.9 65.4 82 174.917298557556 0.0306182725011187 0.247980310739386 0.123470578812593 0.901734470704854 0.989837048745233 Probable exported protease II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2224c caeA 178 122.2 88.7 135.7 141.2 88.2 313.790177598696 -0.265450252024871 0.200819594978468 -1.32183441587627 0.186223295331188 0.739746500217031 Probable carboxylesterase CaeA II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2225 panB 45.2 13.4 22.8 32.2 36.7 9.9 34.5885844102597 -0.236103708892249 0.442585673786996 -0.533464418023342 0.593712135644628 0.929159985017801 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB I.G.5 - Pantothenate Rv2226 - 27.9 14.5 17.2 31.6 25.9 20.1 55.7123045230898 0.204174425160143 0.324782265014638 0.628650167061742 0.529578109317545 0.922751607774049 hypothetical protein VI - Unknowns Rv2227 - 11.4 7.4 7.5 6.5 21.1 12.2 12.284201756818 0.311063460633328 0.66305556024389 0.46913634284118 0.638972183158385 NA hypothetical protein VI - Unknowns Rv2228c - 71 32.1 33 48.9 51.8 39.2 79.4411552808615 -0.136793021695054 0.285124489159279 -0.479765951000574 0.631393826444729 0.93413540068838 Multifunctional protein Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities VI - Unknowns Rv2229c - 64 48.4 38.1 62.4 36.2 45.7 58.1186442862707 -0.232887393227747 0.329151702754043 -0.707538169419013 0.479232101395519 0.907292899730371 hypothetical protein VI - Unknowns Rv2230c - 33.2 22 15.2 35.4 12.7 15.5 40.0173200495625 -0.263515009705083 0.407733839385438 -0.646291733112634 0.518090440673099 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv2231c cobC 20.4 19 9.3 29.6 10.5 10.3 27.8883957332313 -0.0576076999002809 0.482994267138764 -0.119272015880326 0.905059853306074 0.991443783859248 Possible aminotransferase CobC I.G.13 - Cobalamin Rv2231A vapC16 0.9 0 2.5 1.3 0 0 0.40242107961017 -0.683201218374596 2.97742165162528 -0.229460687236441 0.818510872538435 NA Possible toxin VapC16 ? Rv2231B vapB16 11 9 10.2 12.1 1.6 1.2 1.68392388131533 -0.919332619734602 1.65155582400928 -0.556646409627771 0.57776903842915 NA Possible antitoxin VapB16 ? Rv2232 ptkA 36.9 16.2 25.2 23.2 15.2 19.4 32.3283282840795 -0.624460036430318 0.422019657174107 -1.47969419389555 0.13895487579738 0.682181933169668 Protein tyrosine kinase transcriptional regulatory protein PtkA VI - Unknowns Rv2234 ptpA 42.4 27.7 40.8 30.3 34.7 9.7 24.7969030178885 -0.847001395990681 0.500729545817745 -1.69153468786715 0.0907347285326056 NA Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2235 - 131.3 68.6 62.1 110.9 96.7 44.2 109.225404551101 -0.20570373872206 0.2781428101605 -0.739561589254672 0.459566055721102 0.901158530199572 Probable conserved transmembrane protein VI - Unknowns Rv2236c cobD 10.1 3.7 5.3 9.9 3.9 6.5 9.07158200703428 -0.0651718700007443 0.718115451865615 -0.0907540282435536 0.927688039387415 NA Probable cobalamin biosynthesis transmembrane protein CobD I.G.13 - Cobalamin Rv2237 - 40.9 30.2 16.3 39.8 28.6 14.7 33.4086930252467 -0.190676828988878 0.414660947415419 -0.459837923434475 0.645632560248542 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv2237A - 277.2 187.5 161.4 316.1 231.4 328.1 94.8963411714209 0.29842506899397 0.283077957313016 1.05421514209947 0.291784429007174 0.832895490850201 hypothetical protein ? Rv2238c ahpE 365.7 270 194.2 327 314.7 240.7 211.26199827375 -0.0893554063810714 0.213372975583324 -0.418775649244191 0.675380102738371 0.942004486195686 Probable peroxiredoxin AhpE III.F - Detoxification Rv2239c - 415.6 283.5 287.6 299.8 368.7 228 244.488849957891 -0.360854234388485 0.230935696454199 -1.56257451718839 0.118152705985766 0.657566166512329 hypothetical protein VI - Unknowns Rv2240c - 78.2 48.7 41.8 65 79.6 79.3 61.4436480328882 0.205114877185364 0.319741752598136 0.641501697912941 0.521196778104994 0.916731142491682 hypothetical protein V - Conserved hypotheticals Rv2241 aceE 320.6 174.7 160.6 196.6 207.5 171 890.535291814992 -0.351975540483636 0.172948935660098 -2.03514140830207 0.0418366465187424 0.414767613873984 Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase) I.B.2 - Pyruvate dehydrogenase Rv2242 - 126.2 48.4 68.1 86.3 91.2 55.1 155.860353607612 -0.23960996639218 0.260455876170158 -0.919963757068933 0.357591699107308 0.877159041773689 hypothetical protein VI - Unknowns Rv2243 fabD 200.5 97 69.3 138 138.1 128.7 182.147557782197 0.015273226737544 0.235386985809364 0.0648856039556645 0.948265082817705 0.998153412295216 Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT) I.H.1 - Synthesis of fatty and mycolic acids Rv2244 acpM 832.2 433.8 311.3 812.5 522.5 558 313.848464738378 0.141336893453016 0.218771901444026 0.646046830146408 0.518249027675142 0.915911629458156 Meromycolate extension acyl carrier protein AcpM I.H.1 - Synthesis of fatty and mycolic acids Rv2245 kasA 858.3 287.6 383.9 792.7 473 435.5 1047.33049328343 0.0165896255673377 0.240511467410555 0.0689764431856345 0.94500837044486 0.998153412295216 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) I.H.1 - Synthesis of fatty and mycolic acids Rv2246 kasB 618 211.7 297.7 491.2 343.8 353 800.175855737795 -0.0619376943640786 0.231063440388343 -0.268054930109157 0.788657037179165 0.963989543249515 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) I.H.1 - Synthesis of fatty and mycolic acids Rv2247 accD6 665.9 223.6 315.7 643.7 380.3 353.7 954.828764517813 0.0468200926252457 0.24412274021152 0.191789149116868 0.847907370933085 0.975474031954732 Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 I.H.1 - Synthesis of fatty and mycolic acids Rv2248 - 193.8 81.8 77.6 139.9 106.4 65.3 139.975763100865 -0.30837825494885 0.264735297389779 -1.16485507595466 0.244077660598338 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2249c glpD1 3.3 1.1 0 6.8 2.4 0 4.45200527074994 1.12107418102838 1.16460501413052 0.962621805183768 0.33573735075214 NA Probable glycerol-3-phosphate dehydrogenase GlpD1 I.B.6.a - aerobic Rv2250c - 2 0 0 2.9 3.2 0 0.863576764776729 1.06250064409651 2.25260863226949 0.471675651453955 0.637158319149502 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2250A - 8.5 0 2.3 11.8 5.3 12.9 4.04968128332204 1.25123715514948 1.11121816435552 1.12600495139959 0.26016342351863 NA Possible flavoprotein ? Rv2251 - 10.6 9.1 4.7 17.1 20.3 11 26.5069364521213 0.877186383488685 0.439189312120242 1.99728536027882 0.0457941927693854 NA Possible flavoprotein V - Conserved hypotheticals Rv2252 - 8.7 1.9 3.2 12.7 4.6 9.2 8.88248737953683 0.841681929250093 0.768699805738816 1.0949422947247 0.273541918068591 NA Diacylglycerol kinase V - Conserved hypotheticals Rv2253 - 2.2 3.4 2.6 4 1.8 1 1.5047207450103 -0.633880755825124 1.73969126632943 -0.364363935195552 0.715586262728394 NA Possible secreted unknown protein VI - Unknowns Rv2254c - 13.3 3.6 11.7 12.9 14 16.6 8.21314259039509 0.268752180629017 0.765023599202459 0.351299202938566 0.725363892849177 NA Probable integral membrane protein VI - Unknowns Rv2255c - 75.5 9.3 24.3 71.6 122.2 37.7 15.796855404349 0.933824217638528 0.630754396123171 1.48048784658201 0.138743101746735 NA Hypothetical protein VI - Unknowns Rv2256c - 615.8 374.3 277.6 583.7 493.5 360.3 379.272882845045 0.0220921188939681 0.190627570044974 0.115891520249437 0.90773851627219 0.992210970746976 hypothetical protein V - Conserved hypotheticals Rv2257c - 58 47.5 32 109.1 73.8 33.9 74.6649337620755 0.501897395604166 0.333918760801566 1.50305240232495 0.132825531485864 0.680441181456551 hypothetical protein VI - Unknowns Rv2258c - 92.3 96.2 60.6 184.2 126.2 97.4 184.343696773286 0.49960132007339 0.263428700727492 1.89653336441199 0.057889552478475 0.497736055470808 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2259 mscR 249.6 178.5 116.3 224.8 215.2 192.6 339.836436264798 0.0525296313494252 0.196426251100251 0.267426736778759 0.789140615855993 0.963989543249515 S-nitrosomycothiol reductase MscR I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2260 - 170.2 91.7 99.1 136.4 103.1 99.5 119.401019299127 -0.273988238893565 0.255279412124423 -1.07328764436367 0.283142077130726 0.825259204787765 hypothetical protein V - Conserved hypotheticals Rv2261c - 8.1 6.9 2.5 8.2 0 5.3 2.85288766327525 -0.275444789251108 1.27228793907389 -0.216495638127016 0.828601424816509 NA hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2262c - 15 12.1 7.9 16.2 8.2 5.6 18.0980319251987 -0.317798334765417 0.534950801645996 -0.594070209424081 0.552465155032667 NA hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2263 - 26.5 7.7 10.6 15.3 21.2 10.4 21.8069755557451 -0.133127085365696 0.494160321055651 -0.269400596715866 0.787621427018129 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2264c - 8.8 2.4 5.7 7.4 6.3 6.4 16.9350306753349 -0.00130326787864034 0.541966890341589 -0.00240470017978206 0.998081328702338 NA Conserved hypothetical proline rich protein V - Conserved hypotheticals Rv2265 - 2.9 1.4 2.2 1.8 1.5 0 2.78686353763566 -1.21003169190991 1.29344951708506 -0.93550747510955 0.349526832830885 NA Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2266 cyp124 49.8 29.3 22.1 34.1 28.9 26.4 64.8111923461904 -0.334554058214954 0.300338193360739 -1.11392445453355 0.265311597313223 0.80816433845196 Probable cytochrome P450 124 Cyp124 IV.F - Cytochrome P450 enzymes Rv2267c - 7 5.3 3.7 4.2 9.2 2.4 9.12254478068877 -0.326692679833092 0.724539296655591 -0.450897116748638 0.652063701663733 NA hypothetical protein VI - Unknowns Rv2268c cyp128 4.9 4 0.7 4.1 5.5 5.8 9.08989391534893 0.636345966501096 0.743608395008554 0.85575414529011 0.392133783760787 NA Probable cytochrome P450 128 Cyp128 IV.F - Cytochrome P450 enzymes Rv2269c - 1.6 0 3.2 0 0 2.5 0.350438831133944 -1.60913884557631 3.37835936289465 -0.476307779228544 0.63385512406938 NA Hypothetical protein VI - Unknowns Rv2270 lppN 13.1 6.3 5.1 3.7 19.2 8.5 7.18550017359294 0.00605308961919075 0.858729321969698 0.00704889126798019 0.99437584506098 NA Probable lipoprotein LppN II.C.1 - Lipoproteins(lppA-lpr0) Rv2271 - 47.1 44.6 28.6 59.2 97.1 107.9 30.6817776821745 0.978201724389008 0.454176672266518 2.1537912097233 0.0312565493742014 0.375387808282729 hypothetical protein VI - Unknowns Rv2272 - 68.3 29.8 20.3 61 81.5 52.1 28.9019153954995 0.576550654312486 0.435426941934834 1.32410422687803 0.185468431978063 0.739746500217031 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2273 - 21.7 16.1 9.4 40.4 13.9 35.7 11.18936301687 0.801639897382508 0.661310191243157 1.21219952149165 0.225436014625141 NA Probable conserved transmembrane protein VI - Unknowns Rv2274c mazF8 17.8 16.2 0 9.9 24.7 0 5.31641470535398 -0.0547402997665295 1.04318965539821 -0.0524739672055452 0.958151037909745 NA Possible toxin MazF8 VI - Unknowns Rv2274A mazE8 18.3 13.2 4.3 7.9 34.4 0 4.38542379066039 0.0645734400133462 1.08577796782361 0.059472048546703 0.952576128087902 NA Possible antitoxin MazE8 ? Rv2275 - 69 62.9 34.8 48.3 82.1 69.7 85.61197111069 0.06752679169972 0.322438813710029 0.209425133788165 0.834116373833581 0.970212737604577 hypothetical protein VI - Unknowns Rv2276 cyp121 45.1 32.7 30.7 39.8 62.9 36.1 78.6341979871531 0.139692502548202 0.310573423897689 0.449788976774202 0.652862606924701 0.939577115195416 Cytochrome P450 121 Cyp121 IV.F - Cytochrome P450 enzymes Rv2277c - 1.7 1.9 0 1.2 0 3.1 1.355418404427 -0.0522952241749457 1.82350115236987 -0.028678470593222 0.977121027282223 NA Possible glycerolphosphodiesterase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2278 - 14.1 12.6 9.7 22.6 1.4 30.2 7.44596290908982 0.335016437430041 0.862616103392702 0.388372575137896 0.697740336427002 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2279 - 4.9 9.8 2 4.6 0 3.4 6.71846128733593 -1.11518745919344 0.937405600207546 -1.18965307967707 0.234182774103055 NA Probable transposase IV.B.1.a - IS6110 Rv2280 - 177.7 81.4 98.1 131.1 90.6 81 242.264846931012 -0.415591942500039 0.233174539113004 -1.78232127779024 0.0746968547881383 0.54162997700187 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2281 pitB 30.8 10.2 20.8 18.3 16.8 19.1 51.6993435950954 -0.423599029451683 0.371106271401839 -1.14144939629167 0.253682958852124 0.797371663846564 Putative phosphate-transport permease PitB III.A.4 - Anions Rv2282c - 5.6 0 1.1 7.1 3.9 6 5.07724225676564 1.18055316589673 1.02033315977248 1.15702714803465 0.24726126891429 NA Probable transcription regulator (LysR family) I.J.1 - Repressors/activators Rv2283 - 1.6 0 0 0 3.1 0 0.0448007840762574 -0.318231606298853 4.0267484609073 -0.0790294227186839 0.937009220301446 NA Hypothetical protein VI - Unknowns Rv2284 lipM 29.5 27.7 9.5 23 33.9 21.2 48.9637090215838 0.0806177472620631 0.374617515891637 0.215200154403306 0.82961127055069 0.968638603196576 Probable esterase LipM II.B.5 - Esterases and lipases Rv2285 - 48.9 34.4 24.4 37.9 52.1 37.9 83.1292446815863 0.0520376641304767 0.288067595136724 0.180643935690782 0.856647067466123 0.975712312098852 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv2286c - 21.6 7.5 10.5 17.7 15.4 11.9 14.5673810858535 -0.0795597839486678 0.564957664537336 -0.140824328870416 0.888008722932214 NA hypothetical protein V - Conserved hypotheticals Rv2287 yjcE 7.8 3.2 3.3 8.3 6.8 3.9 13.4185335132957 0.226117344997539 0.587651928202886 0.384781082381596 0.700399616118851 NA Probable conserved integral membrane transport protein YjcE III.A.2 - Cations Rv2288 - 95.5 56.4 40.2 72.9 71.6 27.1 35.3690188999886 -0.268811444044794 0.394797821784188 -0.680883807387715 0.49594501480584 0.913636152872564 Hypothetical protein VI - Unknowns Rv2289 cdh 131.7 108.8 63 116.4 156.6 119.6 145.092549667448 0.197874639309764 0.258087523461922 0.766695873769962 0.443262357506682 0.901158530199572 Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2290 lppO 448.3 261 190.1 266 305.7 280.1 240.128720371292 -0.231080633492771 0.218472610518511 -1.05770985637209 0.290187740302503 0.83177128463909 Probable conserved lipoprotein LppO II.C.1 - Lipoproteins(lppA-lpr0) Rv2291 sseB 301.3 166.4 125.3 213.1 214.7 141.3 260.371128451691 -0.206016762646271 0.206088158887111 -0.999653564565643 0.317478191369738 0.847340730510678 Probable thiosulfate sulfurtransferase SseB I.C.5 - Sulphur metabolism Rv2292c - 19.5 30.4 14.1 19.4 5.4 56.7 8.68150877498457 0.174911493897276 0.828213409346365 0.211191332962501 0.832737973531775 NA Hypothetical protein VI - Unknowns Rv2293c - 31.1 23.3 14.7 31.3 26.2 23.8 29.0408633264326 0.0680396842498855 0.411339749178165 0.165409942476566 0.868621328505767 0.977876220223739 hypothetical protein VI - Unknowns Rv2294 - 6 3.8 0.9 7.8 4.3 0.5 6.1884022455909 0.212962761069937 0.934648235459663 0.227853381614957 0.819760225486446 NA Probable aminotransferase IV.H - Miscellaneous transferases Rv2295 - 249.9 187.1 127.6 212.4 229.6 134.6 193.56384531791 -0.147854610284777 0.227482522508207 -0.649960307519637 0.51571786109056 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv2296 - 96.8 75.6 58.4 69.3 76.8 59.4 106.839755151969 -0.379326766169342 0.264293297203574 -1.4352492862396 0.151216073510809 0.698269882021534 Probable haloalkane dehalogenase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2297 - 64.2 65.6 64.5 79.9 77 50.6 49.7711854697291 -0.137126262357904 0.373198308313447 -0.367435380341361 0.713294284707078 0.949890877982223 hypothetical protein VI - Unknowns Rv2298 - 54 48.1 46.3 44.8 64.5 31.7 77.1783583893666 -0.317278003180833 0.327016824144337 -0.970219205115866 0.331937239790572 0.853347384539607 hypothetical protein V - Conserved hypotheticals Rv2299c htpG 59.8 35.2 35 61.3 63.2 51.8 158.194324023166 0.247641171456768 0.230473097097779 1.07449057861927 0.282602865133817 0.825259204787765 Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) III.B - Chaperones/Heat shock Rv2300c - 10.9 3.7 6.9 11.7 5.9 17.2 13.8568572265327 0.432136557593312 0.617957726460389 0.699297927818711 0.484365861766138 NA hypothetical protein V - Conserved hypotheticals Rv2301 cut2 27 16.2 18.1 16.4 32.6 23 24.371709445898 -0.00971504302410105 0.477949095721841 -0.0203265224499034 0.983782898300033 NA Probable cutinase Cut2 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2302 - 188 91.3 84 147.8 128.5 126.8 48.6737238280558 -0.00921464606647196 0.336645309809447 -0.0273719722151715 0.978163052802128 0.998567088804884 hypothetical protein V - Conserved hypotheticals Rv2303c - 11.6 8.9 7.4 8.7 5.6 1.5 9.89345896232656 -0.977159120879851 0.731239412981112 -1.33630532426606 0.181449496966459 NA Probable antibiotic-resistance protein IV.D - Antibiotic production and resistance Rv2304c - 29.3 26.4 10.7 22.3 11.5 17.3 6.23398013344441 -0.445352075028221 0.849358908463377 -0.524339087505343 0.60004271486653 NA Hypothetical protein VI - Unknowns Rv2305 - 19.3 6.6 11.1 9.9 7.6 3.3 19.2601341904857 -1.02802123118649 0.539255990924243 -1.90636960643598 0.0566022691568159 NA hypothetical protein VI - Unknowns Rv2306A - 11.8 4 3.1 15.2 8 23.6 9.66230991482999 1.203679095876 0.750092295003351 1.6047079857961 0.10855808366825 NA Possible conserved membrane protein ? Rv2306B - 12.4 4 7.4 12.4 2.6 6.5 4.6558520171408 -0.332620350840106 1.00594167642067 -0.330655701654228 0.7409045666962 NA Possible conserved membrane protein ? Rv2307c - 32.3 21.2 13.4 22.3 35.2 10.1 29.1171944353374 -0.145812759569008 0.437091418851751 -0.333597854545078 0.738683037430254 0.955658223354576 hypothetical protein V - Conserved hypotheticals Rv2307A - 16.4 9.3 4.6 13 15.7 18.9 3.2686295404171 0.509839237862286 1.1473022944881 0.444380910167851 0.656767212815307 NA Hypothetical glycine rich protein ? Rv2307B - 30.9 12.2 18.7 20.4 10.9 10.6 11.420651168499 -0.772495001207841 0.653737874162658 -1.18165863068174 0.237341179407469 NA Hypothetical glycine rich protein ? Rv2307D - 72.2 46.6 22.9 57.7 32.4 58.6 13.5019147409026 -0.093718521829793 0.596955684938642 -0.156994102232942 0.875249496201151 NA Hypothetical protein ? Rv2308 - 21 9.6 4.3 21.1 13.4 31.1 18.0541184563762 0.809312667162725 0.576666602221493 1.40343252764251 0.16048789897419 NA hypothetical protein I.J.1 - Repressors/activators Rv2309c - 114.2 35.5 23.7 63.3 69.9 70.7 42.8742061992149 0.140944924700781 0.412878488362784 0.341371441412897 0.732823971691271 0.951639016759651 Possible integrase (fragment) IV.B.3 - Phage-related functions Rv2309A - 1.3 3.4 0 0 0 2.4 0.0672011761143861 -0.532844597337511 4.02464265437721 -0.132395505165655 0.894671469740181 NA Hypothetical protein ? Rv2310 - 0.3 0.1 0 0 0 2.2 0.0224003920381287 -0.0353864558230091 4.03001480255116 -0.00878072601634317 0.992994084306394 NA Possible excisionase IV.B.3 - Phage-related functions Rv2311 - 8.3 16.1 1.1 8.3 13.1 10.8 7.6230774723331 0.274291250444133 0.874297621645479 0.313727549581916 0.753727974866495 NA hypothetical protein VI - Unknowns Rv2312 - 24.1 18.8 6.7 10.2 33.9 10.5 6.35894066804501 -0.000746287164734565 0.880594812685501 -0.000847480764119714 0.999323808263674 NA Hypothetical protein VI - Unknowns Rv2313c - 110.8 69.9 65.6 110.5 101.5 82.6 123.043718075011 0.0701104182804795 0.244965932265964 0.286204769912085 0.774721290627221 0.963013023606306 Hypothetical protein VI - Unknowns Rv2314c - 105.1 54.8 66.5 97.4 64 47.1 159.717778252493 -0.307579478536039 0.263096948400815 -1.16907277110435 0.242374313286795 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2315c - 71.8 39.2 52.5 74.7 72.4 57.2 150.392193793368 0.101537259199434 0.256054377589472 0.396545687503249 0.691702510540063 0.942913432418385 hypothetical protein V - Conserved hypotheticals Rv2316 uspA 1.8 1.8 1.2 2.1 2.1 0 1.5267620514907 -0.187531656640283 1.62792150385479 -0.115196989655965 0.908288984699849 NA Probable sugar-transport integral membrane protein ABC transporter UspA III.A.3 - Carbohydrates, organic acids and alcohols Rv2317 uspB 1.8 2.4 1.4 2.9 0 0 1.38546729865761 -0.250725608900253 1.7867798608085 -0.140322607389811 0.88840510292675 NA Probable sugar-transport integral membrane protein ABC transporter UspB III.A.3 - Carbohydrates, organic acids and alcohols Rv2318 uspC 11.6 5.2 5.3 9.6 5.6 16.8 18.6079450510932 0.360685692643304 0.558377472397145 0.645953159777133 0.518309690590389 NA Probable periplasmic sugar-binding lipoprotein UspC III.A.3 - Carbohydrates, organic acids and alcohols Rv2319c - 9.6 1.4 7.4 7.5 5.3 9.7 9.5922495271338 -0.0104733783338011 0.735361048720862 -0.0142424980926297 0.988636514844055 NA Universal stress protein family protein VI - Unknowns Rv2320c rocE 16.3 13.2 6 12.9 10.3 13.1 27.1065317580939 -0.117523180140048 0.439979588626084 -0.267110527802063 0.789384061988486 0.963989543249515 Probable cationic amino acid transport integral membrane protein RocE III.A.1 - Amino acids Rv2321c rocD2 14.5 16.1 3 11.6 6.9 7.2 7.97656253032296 -0.450183444341899 0.79060108320644 -0.569419210148423 0.569071683200394 NA Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) I.A.2 - Amino acids and amines Rv2322c rocD1 18.1 10.3 7.5 9.2 11 9.4 10.6513840870932 -0.5332811588465 0.651491309303267 -0.818554524413862 0.413040621627134 NA Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) I.A.2 - Amino acids and amines Rv2323c - 21.6 9.5 9.8 12.1 12.8 11.9 18.0692610260549 -0.359231291292841 0.512920992953608 -0.700363791359446 0.483700142810365 NA hypothetical protein V - Conserved hypotheticals Rv2324 - 18.1 11.1 8.5 11.1 17.6 6.3 7.70807678729991 -0.236879032421531 0.763208696008198 -0.310372554270512 0.756277662817426 NA Probable transcriptional regulatory protein (probably AsnC-family) I.J.1 - Repressors/activators Rv2325c - 180.5 89.7 74.5 140.6 113.3 82.9 150.419452642309 -0.174291923489418 0.239288924836428 -0.72837438510186 0.466384438929635 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2326c - 282.7 169.4 160.2 195.5 176.6 148.9 639.552408283928 -0.420040914408629 0.177550714693861 -2.36575175229724 0.0179935051039624 0.278044888924916 Possible transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2327 - 806.9 419 398.4 501.8 457 311.4 378.405125898226 -0.521054087266529 0.195301492687304 -2.66794728548637 0.00763162309608748 0.174455119700644 hypothetical protein V - Conserved hypotheticals Rv2328 PE23 91.5 55.2 48.9 55 59.1 39.9 107.775299086782 -0.523589146470899 0.25574251863308 -2.04732927973587 0.0406257649128964 0.409898801332397 PE family protein PE23 IV.C.1.a - PE subfamily Rv2329c narK1 34.9 21.8 17.5 48.3 63.1 44.3 92.7573329659767 0.894898780428785 0.276250701635742 3.23944437110889 0.00119762825718632 0.0561464365996163 Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1) III.A.4 - Anions Rv2330c lppP 6.7 2.4 5.1 2.8 12.9 0 3.95399607368718 -0.104395413451414 1.12348733824214 -0.0929208633670547 0.925966430884961 NA Probable lipoprotein LppP II.C.1 - Lipoproteins(lppA-lpr0) Rv2331 - 271.3 168.3 112.4 265 332 366.4 154.76865754065 0.652619294845051 0.265172436526136 2.46111286449913 0.0138506786773347 0.260180903193056 Hypothetical protein VI - Unknowns Rv2331A - 49.3 22.5 17.1 31.8 34.3 24.1 15.0221352154651 -0.203542583019425 0.555560241927576 -0.366373558901933 0.714086347136171 NA Hypothetical protein ? Rv2332 mez 27 29.3 16.3 22.3 27.5 26.6 66.3388744822463 -0.143442333010609 0.334659556731086 -0.428621654829572 0.668198583829266 0.940354944889996 Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2333c stp 12.5 1.1 5.6 11.8 7.7 7 18.1265149380299 0.292497584712376 0.589839860671309 0.495893214777784 0.619969753618015 NA Integral membrane drug efflux protein Stp III.A.6 - Efflux proteins Rv2334 cysK1 358 216.4 184.6 273.3 256.1 212.7 373.586367521059 -0.208388945109127 0.18529447095675 -1.12463660698094 0.260743054739141 0.804927778357659 Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) I.D.3 - Serine family Rv2335 cysE 261.5 182.8 129.7 204.6 232.1 194.4 222.16813999624 -0.0357271307727748 0.21610900103083 -0.165319957069618 0.868692151475255 0.977876220223739 Probable serine acetyltransferase CysE (sat) I.D.3 - Serine family Rv2336 - 130.8 108.1 54.4 75.8 132.2 158.2 172.482173965766 0.183026594893652 0.318821682818843 0.574071980536058 0.56591909315447 0.92521033104044 Hypothetical protein VI - Unknowns Rv2337c - 38 20.8 15.8 54.2 22.6 33.1 52.7544238101111 0.420356305244593 0.363653253903479 1.15592614869373 0.247711365900021 0.793939325700415 Hypothetical protein VI - Unknowns Rv2338c moeW 44.8 28.7 16 30.6 60.3 66.8 62.2737813834931 0.677749901529743 0.382576369640743 1.77154146286186 0.076470704109996 0.545639518948021 Possible molybdopterin biosynthesis protein MoeW I.G.4 - Molybdopterin Rv2339 mmpL9 61.5 53.9 24.4 49.5 58.6 67.7 244.228528619655 0.189823801752475 0.269108051960569 0.705381352841454 0.480572945281103 0.907292899730371 Probable conserved transmembrane transport protein MmpL9 II.C.4 - Conserved membrane proteins Rv2340c PE_PGRS39 50 29 16.8 33.5 33.2 24.3 59.6622492979127 -0.210322533881594 0.318606289794704 -0.660133025048302 0.509168467244237 0.915911629458156 PE-PGRS family protein PE_PGRS39 IV.C.1.a - PE subfamily Rv2341 lppQ 7.5 6.8 1.6 7.8 10.9 0 3.27602387517109 0.286807643536912 1.15984306347081 0.247281423297601 0.80469043450594 NA Probable conserved lipoprotein LppQ II.C.1 - Lipoproteins(lppA-lpr0) Rv2342 - 76.6 34.5 24.3 46 31.2 54.6 17.4059357992652 -0.198707033615343 0.540010790973579 -0.367968634954676 0.712896621568058 NA hypothetical protein VI - Unknowns Rv2343c dnaG 111.2 85.5 62.1 101.4 84.7 70.3 265.529324768697 -0.20020594283916 0.208087630966363 -0.962123226207149 0.335987708333781 0.854144996193932 Probable DNA primase DnaG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2344c dgt 78.4 34.5 38.1 71.2 61 42.1 109.930895261028 0.0511107018127071 0.263151401228036 0.194225459466266 0.845999348667675 0.975474031954732 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2345 - 57.2 31 34.5 54.6 41.5 32.8 132.834459995069 -0.110945124325723 0.251974190457383 -0.440303525231438 0.659717287855463 0.939577115195416 Possible conserved transmembrane protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2346c esxO 1018.2 674.7 630.6 754.6 794.7 603.3 345.27466279824 -0.312424259843327 0.20025150513755 -1.56015935874603 0.11872222707359 0.659408996155725 Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6) V - Conserved hypotheticals Rv2347c esxP 514.8 481.9 524.5 363.4 649.1 611.5 263.339446511929 -0.178109284738787 0.308979578228947 -0.576443549310604 0.564315415687372 0.92521033104044 Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7) V - Conserved hypotheticals Rv2348c - 400.7 362.7 372.3 411.1 509.4 624.8 243.995988733266 0.200860652394852 0.290312512662244 0.691877351592275 0.489014354824262 0.910063990546522 Hypothetical protein VI - Unknowns Rv2349c plcC 41.7 23 16.2 31.9 50.9 29.9 76.1538019966304 0.316019095517304 0.310205135748832 1.01874230661732 0.308325321920928 0.844880251285152 Probable phospholipase C 3 PlcC II.B.5 - Esterases and lipases Rv2350c plcB 57.9 47.7 28.9 51.3 81 46.5 127.695899015075 0.231955857154232 0.275356361801328 0.842384231244273 0.399572916596321 0.893826103932853 Membrane-associated phospholipase C 2 PlcB II.B.5 - Esterases and lipases Rv2351c plcA 9.4 6.8 7.4 9.8 6.4 6.6 19.132158534026 -0.243513784049259 0.509925200935846 -0.477548047443719 0.632971915464473 NA Membrane-associated phospholipase C 1 PlcA (MTP40 antigen) II.B.5 - Esterases and lipases Rv2352c PPE38 6.8 13 9.6 17.5 4.7 4.5 18.139693925288 -0.270078279536157 0.627508115286783 -0.430398066505843 0.666906101575258 NA PPE family protein PPE38 IV.C.2 - PPE family Rv2353c PPE39 0.9 1.6 0.8 0 3.5 0 1.57816617237563 0.0724754348256834 1.80120823015383 0.0402371217343891 0.967904082717829 NA PPE family protein PPE39 IV.C.2 - PPE family Rv2354 - 6.7 0 1.7 17.7 0 8.7 2.19603087623857 1.62387790221741 1.63120719816627 0.995506827117307 0.319489825492879 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2355 - 5.8 3.5 6.4 4.7 1.9 2.9 6.26553026735038 -1.0591223427844 0.899850942663548 -1.17699753655801 0.239196489499877 NA Probable transposase IV.B.1.a - IS6110 Rv2356c PPE40 72.9 53.9 56.2 58.2 87 88.1 211.462242130398 0.123949117066153 0.277887805251991 0.446040145423995 0.655568247250746 0.939577115195416 PPE family protein PPE40 IV.C.2 - PPE family Rv2357c glyS 32.6 23.3 17.8 23.7 27.9 26.7 56.528181705478 -0.124511572347448 0.325363782472275 -0.38268418015474 0.701953945599622 0.947279830180307 Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2358 smtB 111.8 50.7 57.5 101.4 94.3 57 49.8868503086278 0.0142106363334456 0.339083609509611 0.0419089449767192 0.966571285604146 0.998153412295216 Probable transcriptional regulatory protein SmtB (probably ArsR-family) I.J.1 - Repressors/activators Rv2359 zur 184.4 131.5 94.6 110 147.9 88.7 79.4661291640077 -0.437668655905484 0.292082544860642 -1.49844166865331 0.134018537180544 0.680441181456551 Probable zinc uptake regulation protein Zur I.J.1 - Repressors/activators Rv2360c - 102.4 56.5 33.6 113.9 51 47.1 43.5886323161052 0.0324488148128578 0.397558435530923 0.0816202397253217 0.934948706020124 0.998096534485397 hypothetical protein VI - Unknowns Rv2361c - 126.7 85.1 60.2 59.1 120.8 91.8 130.156730788232 -0.179638609287071 0.301648841393523 -0.595522291606349 0.551494402969533 0.92521033104044 Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase) V - Conserved hypotheticals Rv2362c recO 89.8 55.9 36.6 79.9 49.9 33.9 71.3651684376735 -0.29011891773247 0.319101327568756 -0.909174900470946 0.36325781089336 0.882928450686174 Possible DNA repair protein RecO V - Conserved hypotheticals Rv2363 amiA2 16.5 9.2 8.8 11.5 9.8 13.6 26.7514878687065 -0.255682764444433 0.43631989481456 -0.585998409614351 0.557876583590131 NA Probable amidase AmiA2 (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2364c era 255.2 186.3 93.5 206.6 162.7 174.2 257.070097985436 -0.114570219254248 0.229967197532022 -0.498202441408169 0.618341361846064 0.931582271037618 Probable GTP-binding protein Era I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2365c - 240 90.8 90.2 150.9 110.7 89.9 68.327145158507 -0.385639551258258 0.316673470596874 -1.21778294383611 0.223306467520986 0.774556499980442 hypothetical protein V - Conserved hypotheticals Rv2366c - 337 189 174.6 257.8 196.8 158.7 457.764363449172 -0.364173683056202 0.191023834313092 -1.90643059996018 0.0565943617833927 0.490622631254473 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2367c - 583.9 388.6 286.7 327.5 325.3 278.7 324.160517864565 -0.606053720986532 0.194120708832334 -3.12204568297755 0.0017959906750276 0.0709672886732334 hypothetical protein V - Conserved hypotheticals Rv2368c phoH1 640.6 400.3 336.7 481.4 460.8 374.5 763.903838398454 -0.242937000142234 0.168214208928089 -1.44421212506542 0.148679315236568 0.695223866622759 Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH) I.A.4 - Phosphorous compounds Rv2369c - 76.9 30 26.3 79.4 59.5 55.8 25.0557912943758 0.428966188999136 0.453185031650338 0.946558599777656 0.343863748498529 NA Hypothetical protein VI - Unknowns Rv2370c - 3.8 1.6 1.8 5.9 5.6 3.6 6.74461800213252 0.833712084628783 0.801639701984897 1.04000847583331 0.298335962857937 NA hypothetical protein V - Conserved hypotheticals Rv2371 PE_PGRS40 24.1 12.9 2.7 21.4 25.7 18.3 4.51897631573048 0.742822411747044 1.02415546961781 0.725302391856819 0.468266538707695 NA PE-PGRS family protein PE_PGRS40 IV.C.1.a - PE subfamily Rv2372c - 84 43.3 36.6 79 77.1 35.1 71.9419831956047 0.0718030665680983 0.306147443113706 0.234537534717969 0.814567697161583 0.966578399978095 hypothetical protein V - Conserved hypotheticals Rv2373c dnaJ2 162.6 76.6 85.1 144.9 91.2 71.8 191.334783740914 -0.245238582025031 0.24989010265227 -0.981385734857569 0.326402558095277 0.853347384539607 Probable chaperone protein DnaJ2 III.B - Chaperones/Heat shock Rv2374c hrcA 239.9 175.1 145.6 159.5 175.7 169.9 299.988217943699 -0.350363388433429 0.216600474191708 -1.61755596215053 0.105758326127985 0.639899789981086 Probable heat shock protein transcriptional repressor HrcA III.B - Chaperones/Heat shock Rv2375 - 138.5 60.8 61.7 42.9 80.4 116.1 42.2896610264163 -0.342614431960512 0.43389123537507 -0.789632064506547 0.429742676663935 0.901158530199572 hypothetical protein VI - Unknowns Rv2376c cfp2 518.1 272.7 138.8 399 384.5 272.9 257.421557198268 0.088715803380553 0.241812070132107 0.36687913606664 0.713709174925315 0.949890877982223 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) V - Conserved hypotheticals Rv2377c mbtH 92 44.3 44.3 49.9 68.5 126 24.4978275933885 0.221680187344213 0.508975993122782 0.43554153897144 0.663169394527836 NA Putative conserved protein MbtH I.I - Polyketide and non-ribosomal peptide synthesis Rv2378c mbtG 29.8 18.4 13.3 29.7 29.4 31.9 51.8875371096985 0.392167975348579 0.331790784721179 1.18197368163235 0.237216143830917 0.78958848015113 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2379c mbtF 30.1 13.9 10.6 24.2 21.6 11.2 125.465167291406 -0.0594948119326557 0.26968283188556 -0.220610305508444 0.825395876122906 0.967727711626973 Peptide synthetase MbtF (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2380c mbtE 22.6 11.9 15 19.6 17.6 12.6 134.110721282113 -0.190188617081357 0.257187094016258 -0.739495182714475 0.459606363846806 0.901158530199572 Peptide synthetase MbtE (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2381c mbtD 9.4 4.4 5.3 9.3 9.8 6.3 34.5647493414442 0.240604876360249 0.387503248329459 0.620910605001391 0.534658443101919 0.9231368624344 Polyketide synthetase MbtD (polyketide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2382c mbtC 41.6 24.5 27 30.1 33.2 12.7 60.5073162799095 -0.472425438336994 0.334867404189672 -1.41078358904532 0.158308434873494 0.708520877886452 Polyketide synthetase MbtC (polyketide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2383c mbtB 3.7 3 3.1 6.4 6.2 6.6 32.6576060447133 0.760826067534662 0.412833723209123 1.84293584744108 0.0653383776185339 0.514454587842348 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2384 mbtA 2 5.5 0 2.3 2.2 1.6 5.8154398996063 -0.594396500546095 1.02413830536816 -0.58038694327757 0.561653708057156 NA Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase I.I - Polyketide and non-ribosomal peptide synthesis Rv2385 mbtJ 7.9 1.6 0 5.2 4 0 3.59070743869224 0.0207304458402345 1.23889896895943 0.0167329591513393 0.986649653237717 NA Putative acetyl hydrolase MbtJ II.B.5 - Esterases and lipases Rv2386c mbtI 3.9 0.2 1.7 2.8 3.3 0.5 3.70177743565079 0.0357556640009916 1.15358420150203 0.0309952788486838 0.975273304798376 NA Isochorismate synthase MbtI I.D.4 - Aromatic amino acid family Rv2387 - 31.7 26.1 27.4 29.8 40.2 30.5 63.4702103319864 -0.0106572863493267 0.338471993579146 -0.031486464320525 0.974881586701364 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv2388c hemN 107.2 79.2 51.5 99 73.4 54.9 138.920443875176 -0.224029556066029 0.248516433767642 -0.901467772853573 0.367339661251924 0.883373818299354 Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase) I.G.12 - Heme and porphyrin Rv2389c rpfD 105.3 66.9 63.7 51.7 63.9 57.6 51.521365811972 -0.711503068584524 0.341795764062753 -2.08166145808025 0.0373734034467773 0.399823674443666 Probable resuscitation-promoting factor RpfD V - Conserved hypotheticals Rv2390c - 62.1 28.7 34.2 28.8 40.7 34.2 33.8450652438823 -0.507732729617185 0.407155435678043 -1.24702431829664 0.212388580941343 0.773070552038584 hypothetical protein V - Conserved hypotheticals Rv2391 sirA 1051.3 808.9 585.5 693.4 877.8 703.6 2167.3302499097 -0.290750431246979 0.188393375320827 -1.54331557971103 0.122754225317973 0.665885176304995 Ferredoxin-dependent sulfite reductase SirA I.B.6.b - anaerobic Rv2392 cysH 725.4 622.5 370 612.9 637.2 468.3 705.821969342249 -0.190842120077028 0.195600673921498 -0.97567209892958 0.329226982956609 0.853347384539607 Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, thioredoxin DEP.) (padops reductase) (3'-phosphoadenylylsulfate reductase) (PAPS sulfotransferase) I.B.6.b - anaerobic Rv2393 che1 352.7 243.9 158.7 423.1 264.7 202.2 364.05538106719 0.0689265600853547 0.225073572289245 0.306240130212961 0.759421819713909 0.959593750764785 Ferrochelatase Che1 V - Conserved hypotheticals Rv2394 ggtB 159.1 151.3 84 143.2 147.5 118.7 418.840204046199 -0.140878170319856 0.216565826099785 -0.650509698861467 0.515363038870801 0.915911629458156 Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv2395 - 57.4 38.8 19 67.3 56.9 54 152.34410836683 0.497710633712844 0.248542878031932 2.00251416437247 0.0452294612660307 0.426978463692289 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2395A aprA 4475.9 1970.2 1523 4487.9 3096.7 2365.1 990.240136588618 0.206115280591315 0.211162198954142 0.976099328441249 0.32901524413306 0.853347384539607 Acid and phagosome regulated protein A AprA ? Rv2395B aprB 959.8 574.5 540.4 1195.8 662.4 730.1 203.257077907499 0.13906197891907 0.243762821693417 0.570480674423641 0.568351725995295 0.92521033104044 Acid and phagosome regulated protein B AprB ? Rv2396 PE_PGRS41 187.8 105.8 83.9 198.8 162.6 157.1 255.305704471094 0.304985493606407 0.203497225142452 1.49872065033275 0.133946117215604 0.680441181456551 PE-PGRS family protein PE_PGRS41 IV.C.1.b - PE_PGRS subfamily Rv2397c cysA1 30.1 17.2 12.8 34.2 32.7 20.2 39.7817840640057 0.380512003437867 0.363255468958446 1.04750522966358 0.294866621459739 0.837161771605085 Sulfate-transport ATP-binding protein ABC transporter CysA1 III.A.4 - Anions Rv2398c cysW 44.3 31.1 19.6 40.6 56.9 19.3 44.8762156583808 0.147075748825717 0.371126021645006 0.396295975619839 0.691886695725526 0.942913432418385 Probable sulfate-transport integral membrane protein ABC transporter CysW III.A.4 - Anions Rv2399c cysT 25.8 22.2 12.1 23.7 24.4 29 30.8482058705811 0.145966567309482 0.416927999492383 0.350100179136921 0.726263516458739 0.949890877982223 Probable sulfate-transport integral membrane protein ABC transporter CysT III.A.4 - Anions Rv2400c subI 48.6 17.7 36.7 37.5 38.1 38.8 62.8691854306379 -0.0989873186998857 0.352221397826307 -0.281037209297261 0.778681860546208 0.963013023606306 Probable sulfate-binding lipoprotein SubI III.A.4 - Anions Rv2401 - 5.8 3.2 0 1.9 0 0 0.767935760742571 -1.78587048711797 2.35119453172232 -0.759558795762325 0.447518356631418 NA Hypothetical protein VI - Unknowns Rv2401A - 14.9 8.2 5.2 21.7 13.9 0 2.68068791392488 0.465904027377034 1.27917479661316 0.364222331936648 0.715691992138862 NA Possible conserved membrane protein ? Rv2402 - 47.2 32.4 25.3 48.3 38.9 26 110.889489829509 -0.0556822122990006 0.259435491196113 -0.214628353438771 0.830057086203835 0.968638603196576 hypothetical protein V - Conserved hypotheticals Rv2403c lppR 46.7 30.8 21.8 57.9 34.7 34.2 44.2601583287172 0.221486717515191 0.357590948873631 0.619385692542967 0.535662304265694 0.923716916208796 Probable conserved lipoprotein LppR II.C.1 - Lipoproteins(lppA-lpr0) Rv2404c lepA 27.4 13.6 15.6 23.6 26 18.3 64.3972258939817 0.081732775814036 0.307541759667856 0.265761553495393 0.790422854535196 0.964516371138273 Probable GTP-binding protein LepA (GTP-binding elongation factor) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2405 - 168.7 91.9 66.9 86.7 144.4 86.9 96.4053513401733 -0.205331696738479 0.293756305484285 -0.698986516731853 0.484560457176374 0.908019273666837 hypothetical protein VI - Unknowns Rv2406c - 471.7 329.8 156.3 285.6 385.4 248.9 210.916768566667 -0.193728191620797 0.251429292909392 -0.770507642045557 0.440998823607411 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2407 - 10.3 7 2.3 6.1 7.5 5.2 7.55934954019235 -0.270476929118056 0.768955270342588 -0.351745985169659 0.725028770438482 NA hypothetical protein V - Conserved hypotheticals Rv2408 PE24 1.6 0 0 0.8 5.1 0 1.07896509432853 1.40850979195205 2.14158823779766 0.657694026840809 0.510734761329846 NA Possible PE family-related protein PE24 IV.C.1.a - PE subfamily Rv2409c - 50.3 30.6 41.2 32.2 41.3 35.5 53.0343014881712 -0.420672616074369 0.357425143545669 -1.17695305904135 0.239214242544683 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2410c - 46.6 27.6 27.8 40.1 46.2 44 60.6934394453225 0.13301298657398 0.317937243345907 0.418362394962534 0.6756821766494 0.942004486195686 hypothetical protein V - Conserved hypotheticals Rv2411c - 45.1 23.3 27.7 34.9 24.2 33.2 84.2702540461683 -0.25679779970976 0.296882085142733 -0.864982471361646 0.387048409705566 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv2412 rpsT 144.9 97.6 54.7 122.2 156.9 132.6 48.0465244794039 0.297387400046769 0.34813817737509 0.854222315659332 0.392981820806638 0.893826103932853 30S ribosomal protein S20 RpsT II.A.1 - Ribosomal protein synthesis and modification Rv2413c - 48.6 19.7 9.9 46.2 31.8 19.6 41.3221457338378 0.257148678886995 0.412151689494081 0.623917565890962 0.532681723572943 0.923128239106977 hypothetical protein V - Conserved hypotheticals Rv2414c - 20.8 12.3 7.1 25.1 10.8 8.3 32.9236971968981 0.0444119735289748 0.440374244838824 0.100850524410731 0.919669118578692 0.9932884147079 hypothetical protein V - Conserved hypotheticals Rv2415c - 6.6 6 4.6 6.9 5.1 5.5 7.8045409840172 -0.238155518532277 0.75262074441378 -0.316434964489024 0.751672381510868 NA hypothetical protein V - Conserved hypotheticals Rv2416c eis 11.4 5.6 2.8 11.8 11 4.9 13.9312393055031 0.396467734338151 0.593296840231783 0.668245147207025 0.503977121030086 NA Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv2417c - 76.8 36.1 29.9 85.9 67.9 40.7 72.5101610872455 0.312655014437765 0.306265211731803 1.02086362558069 0.307319054705823 0.844880251285152 hypothetical protein V - Conserved hypotheticals Rv2418c - 43 17.3 34 41 39.2 40.9 42.8246931881213 0.106436083626281 0.38562427358108 0.276009812966046 0.78254052923581 0.963989543249515 hypothetical protein VI - Unknowns Rv2419c gpgP 35.4 24.3 13.6 39.1 31.2 26.3 29.0690930890661 0.261788138344152 0.41396785145057 0.63238760552741 0.527133630987348 0.921650836479776 Glucosyl-3-phosphoglycerate phosphatase GpgP I.B.1 - Glycolysis Rv2420c - 47.6 47.3 33.5 43.9 94.9 39.4 30.5242552224162 0.244492252399148 0.454081149806993 0.538432948610769 0.590278184420458 0.928941202821899 hypothetical protein V - Conserved hypotheticals Rv2421c nadD 23.6 9.5 18.2 18.6 29.9 4.6 16.9647811965263 -0.198462357328482 0.594769709915367 -0.333679328351679 0.73862154999375 NA Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase) V - Conserved hypotheticals Rv2422 - 1 0 4 2.4 0 0 0.454403328086395 -0.0798400414410093 2.86710478862414 -0.0278469213116284 0.977784242661965 NA Hypothetical protein VI - Unknowns Rv2423 - 3.3 8.2 2 3.9 11.7 0 7.97254607726605 0.0968235832752323 0.88168515592892 0.109816506066978 0.9125549002712 NA Hypothetical protein VI - Unknowns Rv2424c - 19.9 10.6 7.2 22 10.4 15.3 21.9674040908649 0.22087575192307 0.484106111369822 0.456254830780966 0.648206740874703 NA Probable transposase IV.B.1.c - Others Rv2425c - 90.5 65 34.9 72.4 69.3 63.9 150.787687308838 -0.0341812726687103 0.242464070954171 -0.140974588664607 0.887890017142678 0.982754616813385 hypothetical protein V - Conserved hypotheticals Rv2426c - 91.6 79.8 68 81.1 90.2 80.5 117.774120748487 -0.151668124286922 0.273312665818152 -0.554925341029872 0.578945727906823 0.928575669725434 hypothetical protein V - Conserved hypotheticals Rv2427c proA 177.3 96.4 86.9 159.7 126.5 121.1 253.06613560548 0.0101262915189313 0.205182552174353 0.0493525955868146 0.960638305334128 0.998153412295216 Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase) I.D.1 - Glutamate family Rv2428 ahpC 25.2 6.5 19.4 23.3 43.2 30.4 22.3267103553677 0.65745168517667 0.520290230040787 1.26362489090969 0.206364695234787 NA Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) III.F - Detoxification Rv2429 ahpD 37.4 1.1 32.1 33.2 31.4 10.4 20.1543672430777 -0.162908641787143 1.3045023310435 -0.124881832642514 0.900617101217391 NA Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) III.F - Detoxification Rv2430c PPE41 450.9 286.6 182.3 407.3 436.4 414.7 335.587342767365 0.310013916256718 0.207609576830483 1.49325441046416 0.135370604307427 0.682181933169668 PPE family protein PPE41 IV.C.2 - PPE family Rv2431c PE25 446.4 326.6 264.7 479 672.2 609.2 224.441024052006 0.573156167854595 0.245636552589807 2.3333504798519 0.0196297580470623 0.291913498699861 PE family protein PE25 IV.C.1.a - PE subfamily Rv2432c - 29.6 23 23.2 35.1 47.3 37.2 21.3444191683957 0.45271453762832 0.486440323261093 0.930668195007612 0.352025226611335 NA Hypothetical protein VI - Unknowns Rv2433c - 21.7 16.4 11.7 23.3 5.3 17.8 7.14986333589793 -0.204604614526747 0.813129797776273 -0.251626019715788 0.801330144772523 NA Hypothetical protein VI - Unknowns Rv2434c - 11.6 9.9 6.1 16.8 6.2 21.5 27.6959942653606 0.563123931649012 0.483448548933114 1.1648063333559 0.244097394671181 0.78958848015113 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv2435c - 14.9 21.3 7 16.9 15.3 19.4 56.3992027433128 0.0954670577025058 0.388430854789979 0.245776195493337 0.805855485180401 0.965592404376002 Probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-) VI - Unknowns Rv2436 rbsK 44.3 36.1 9.5 53.9 41.3 33 50.397448861602 0.429061214530533 0.379490689942845 1.13062382266915 0.258213456276721 0.802492606810575 Ribokinase RbsK I.B.5 - Pentose phosphate pathway Rv2437 - 14 13.2 5 16.3 9.3 6.7 6.39721629550784 -0.163878083406909 0.843225892386344 -0.194346597853075 0.845904501322998 NA Conserved transmembrane protein V - Conserved hypotheticals Rv2438c nadE 162 124.9 93.8 135.2 113.8 104.2 405.390995587763 -0.30246229218822 0.195396969577246 -1.54793747744715 0.121637350340385 0.665646250765128 Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) V - Conserved hypotheticals Rv2438A - 0 0 0 1.3 0 0 0.0743826405143542 1.17188358725511 4.01286532847697 0.292031626114871 0.770262443259805 NA hypothetical protein ? Rv2439c proB 54 25.7 25.1 62.5 45.8 24.2 69.0509028345819 0.190384328662871 0.319716055675812 0.595479411443505 0.55152305737872 0.92521033104044 Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK) I.D.1 - Glutamate family Rv2440c obg 86.1 44 61.6 102.5 83.3 65.6 170.129739472028 0.176051130015335 0.253510265937462 0.694453652061429 0.487397757148782 0.909299509995111 Probable GTP1/Obg-family GTP-binding protein Obg I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2441c rpmA 357 268 352.7 342.7 434.4 506.2 164.209626981395 0.130124855164508 0.30797568155148 0.422516656214484 0.672647945776706 0.940710721884994 50S ribosomal protein L27 RpmA II.A.1 - Ribosomal protein synthesis and modification Rv2442c rplU 186.6 170.5 205.5 202.6 225.6 215.3 105.787723317696 -0.0856906198397548 0.319243308912235 -0.268417903985929 0.788377659621185 0.963989543249515 50S ribosomal protein L21 RplU II.A.1 - Ribosomal protein synthesis and modification Rv2443 dctA 13.9 4.6 6.7 11.3 7.6 9.2 20.3761869593707 0.00197260292444436 0.497782888691388 0.00396277768733694 0.99683816914074 NA Probable C4-dicarboxylate-transport transmembrane protein DctA III.A.3 - Carbohydrates, organic acids and alcohols Rv2444c rne 1004.3 535.5 578 703.4 548.7 493.1 2978.2864995394 -0.467030886159462 0.177556265343323 -2.6303261405978 0.00853029891080422 0.182905478971198 Possible ribonuclease E Rne II.B.1 - RNA Rv2445c ndkA 132.8 65.8 44.5 97.3 84.1 65 51.4919918515093 -0.120440322268106 0.336963649508918 -0.35742823430252 0.720771242948241 0.949890877982223 Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2446c - 78.7 21.8 21.3 79.2 54.7 35.1 26.0931507483071 0.36612480341071 0.481363433808088 0.760599533941081 0.446896298226136 NA Probable conserved integral membrane protein VI - Unknowns Rv2447c folC 86.8 41.1 38.7 74.6 57.3 30.8 124.837691915972 -0.18493901803421 0.272180217400936 -0.679472666309853 0.496838420977535 0.913733425813739 Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) I.G.2 - Folic acid Rv2448c valS 76.9 35.9 32.5 78.2 50.8 50.2 221.583312776622 0.161829450473952 0.229960597179368 0.703726866510641 0.481602885674119 0.907292899730371 Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2449c - 74.8 39.9 56.6 57.3 45.8 37.3 106.889004390171 -0.504497342439168 0.286947654573867 -1.758151127558 0.0787217983425108 0.55131591065269 hypothetical protein V - Conserved hypotheticals Rv2450c rpfE 65.8 3.3 14 140.1 74.1 90.3 48.9072998171794 1.91954564966569 0.922436283724325 2.08095202187358 0.0374382977877474 0.399823674443666 Probable resuscitation-promoting factor RpfE V - Conserved hypotheticals Rv2451 - 4.3 2.1 0.3 2.7 4.1 7.1 1.33273198270877 0.888394645878601 1.8581138254422 0.478116374634465 0.632567378094051 NA Hypothetical proline and serine rich protein VI - Unknowns Rv2452c - 96 23.1 83.9 37 47.9 75.7 14.5481880919838 -0.753497982366616 0.644456903348948 -1.16919840326177 0.242323704364602 NA Hypothetical protein VI - Unknowns Rv2453c mobA 122 23.8 66.3 90.5 55.8 57.5 65.7111143590384 -0.231586330672851 0.38195677747436 -0.606315542308702 0.544305239794423 0.92521033104044 Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA VI - Unknowns Rv2454c - 311.9 149.6 183 209.7 186.1 164.6 363.466596647733 -0.39023021209555 0.210715356446092 -1.85193057913358 0.0640357921890618 0.514454587842348 Probable oxidoreductase (beta subunit) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2455c - 331.7 182.5 157.2 281.2 217.9 218.8 722.166065075366 -0.0588679034296251 0.178273041519165 -0.330212032778364 0.741239755470629 0.955781054558401 Probable oxidoreductase (alpha subunit) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2456c - 91.4 37.7 50.9 93.3 83.1 87.5 147.123154522424 0.371402061358041 0.256478100011786 1.44808489044864 0.147593310701665 0.695223866622759 Probable conserved integral membrane transport protein II.C.5 - Other membrane proteins Rv2457c clpX 1217.3 848.8 608.4 967.6 1148.2 922.6 1956.82437219733 0.0161485731842227 0.175321321231049 0.0921084387844715 0.926611883776754 0.996131826654618 Probable ATP-dependent CLP protease ATP-binding subunit ClpX II.B.3 - Proteins, peptides and glycopeptides Rv2458 mmuM 15.3 9.5 3.7 12.5 12.2 9.3 14.4310074220413 0.160879393203043 0.57247509175422 0.281024267291813 0.778691786945141 NA Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase) V - Conserved hypotheticals Rv2459 - 55.7 53.2 25 49.6 42 43.2 109.57028922486 -0.160535895820094 0.280233982423214 -0.572863770595992 0.566736936704535 0.92521033104044 Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv2460c clpP2 527 290.1 321.6 364.4 419.3 408.2 406.594110312037 -0.122183578736274 0.218041068929471 -0.560369564028307 0.57522738727538 0.926330148899942 Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) II.B.3 - Proteins, peptides and glycopeptides Rv2461c clpP1 427.6 235.3 239.5 291.1 464.9 344.5 323.145071994338 0.104479561851183 0.237584435263116 0.43975760337783 0.660112677226497 0.939577115195416 Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) II.B.3 - Proteins, peptides and glycopeptides Rv2462c tig 341.2 228.2 197.4 243.2 285.8 218 572.325534053886 -0.231778742353928 0.18905296400284 -1.22599898698466 0.22019905624403 0.773070552038584 Probable trigger factor (TF) protein Tig III.D - Protein and peptide secretion Rv2463 lipP 153.7 103.6 54.1 160.9 122.8 92.5 211.07987482608 0.143275803710607 0.236413635036519 0.606038664768532 0.544489078471882 0.92521033104044 Probable esterase/lipase LipP II.B.5 - Esterases and lipases Rv2464c - 40 24.6 21.3 40 62.8 35.1 46.7985657372556 0.480775564301579 0.3557776475292 1.35133718388567 0.176587445914325 0.734764437650925 Possible DNA glycosylase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2465c rpiB 69.6 61.4 46.9 59.6 70.3 89.8 52.895780919098 0.0692161249213333 0.360963931296518 0.191753576798439 0.847935236402938 0.975474031954732 Ribose-5-phosphate isomerase I.B.5 - Pentose phosphate pathway Rv2466c - 10.6 10.8 9.3 11.5 11.6 14.9 11.3328247943091 0.0263150817279934 0.650149872682645 0.0404754085691231 0.967714112090558 NA hypothetical protein V - Conserved hypotheticals Rv2467 pepN 44.6 20.3 18.4 48.3 38.9 37.8 139.466291147277 0.436095782581156 0.24421888783305 1.78567590103544 0.0741517495171078 0.54162997700187 Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase) II.B.3 - Proteins, peptides and glycopeptides Rv2468c - 90.9 69.7 40 81.8 44.8 22.4 45.6957090399109 -0.53203589474403 0.395852990052869 -1.34402393846507 0.178940646055656 0.734764437650925 hypothetical protein VI - Unknowns Rv2468A - 157 136.3 67.1 119.6 111.6 80.6 41.4520426839216 -0.342246357114819 0.367310650099648 -0.931762683771816 0.351459183527777 0.867939293741539 hypothetical protein ? Rv2469c - 28.4 14.3 10.3 23.3 22.6 33.9 22.7988767560484 0.388621223756781 0.481757743476794 0.806673538762747 0.419854593185377 NA hypothetical protein V - Conserved hypotheticals Rv2470 glbO 347.8 266.7 163.5 307.6 325.7 234.4 168.705456932132 -0.0102025486063717 0.230275764017237 -0.0443057854998931 0.964660660043003 0.998153412295216 Globin (oxygen-binding protein) GlbO I.B.6.a - aerobic Rv2471 aglA 213.3 102 105.3 172 156.9 124.4 378.239131046583 -0.052335378040123 0.195496194231095 -0.267705354807355 0.788926127678434 0.963989543249515 Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase) II.A.8 - Polysaccharides (cytoplasmic) Rv2472 - 175.9 144.4 108.6 64.8 123.3 95.4 57.5018387235898 -0.870942551528139 0.361748224071889 -2.40759316445203 0.0160580644691887 0.276757764055105 hypothetical protein VI - Unknowns Rv2473 - 38.4 48.4 28.4 26.7 34.8 19.1 38.6975661525742 -0.727015586710963 0.411053446235616 -1.76866437532368 0.0769499007336669 0.547155335293889 Possible alanine and proline rich membrane protein II.C.5 - Other membrane proteins Rv2474c - 149.1 100 67.7 135.8 99.4 76.2 107.947580382529 -0.169470151971896 0.262618346714325 -0.645309644555201 0.518726543892007 0.915911629458156 hypothetical protein VI - Unknowns Rv2475c - 187.5 78 93.5 148.3 142.9 133 85.5049804259822 0.0545173273512003 0.284368749217193 0.191713497004418 0.847966633018117 0.975474031954732 hypothetical protein V - Conserved hypotheticals Rv2476c gdh 220.4 109.2 115.7 178.6 144.2 122.2 1152.42717996707 -0.172109531521165 0.179846790971822 -0.956978607130837 0.338578052910338 0.854477093385032 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) VI - Unknowns Rv2477c - 215.7 126.1 121.8 193.8 172.4 163.6 445.474419414617 0.00911355763128868 0.189047659812587 0.0482077251859317 0.961550693539626 0.998153412295216 Probable macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2478c - 50.7 35.7 18 44.1 40 65 31.9865548706298 0.344787992874787 0.42606233671475 0.809243068827329 0.418375346044961 0.901158530199572 hypothetical protein VI - Unknowns Rv2479c - 6 3.5 4.7 3.2 11 8.9 9.5816946125618 0.362820758165244 0.746936279983286 0.485745260858615 0.627147789050066 NA Probable transposase IV.B.1.a - IS6110 Rv2480c - 8.2 10.5 3.4 12.4 17.2 0 4.01237671800347 0.539678867964642 1.0761108496486 0.501508620734444 0.616013212289468 NA Possible transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2481c - 8.9 8.1 3.2 6.9 0 9.8 2.44335514102719 -0.64036341164001 1.36301455558105 -0.469814066928304 0.638487863372876 NA Hypothetical protein VI - Unknowns Rv2482c plsB2 96.6 51 50.3 64.7 62 37.8 227.772344497263 -0.442115516186335 0.21910011651013 -2.01786983607511 0.0436048192692389 0.418788752385911 Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2483c plsC 67.1 36.2 43 46.2 50 32.1 129.122842935578 -0.394975217825592 0.256501911988821 -1.53985291869016 0.123596209299687 0.666956030977941 Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT) IV.H - Miscellaneous transferases Rv2484c - 91.6 43.5 53.9 78.7 45.9 66.4 150.373886120607 -0.169002821093534 0.269557976778413 -0.626962789650485 0.530683626854204 0.922751607774049 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv2485c lipQ 8.5 6.8 3.4 7.7 9.1 4.5 12.6808834278431 0.0591455118635159 0.60105150713378 0.098403399977419 0.921611974993699 NA Probable carboxylesterase LipQ II.B.5 - Esterases and lipases Rv2486 echA14 36 11.6 18.5 35 12.6 25 27.5718643824871 -0.0337787452681825 0.477908908564976 -0.0706803004982905 0.943652199544323 0.998153412295216 Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2487c PE_PGRS42 2.3 1.3 1.7 2.3 3.5 2.7 7.05796651816005 0.464016706249961 0.790977405451875 0.586637118900855 0.557447447636903 NA PE-PGRS family protein PE_PGRS42 IV.C.1.b - PE_PGRS subfamily Rv2488c - 13.3 9.6 8.2 9.5 11.9 8.9 55.9795704745759 -0.255867219045756 0.326271319105488 -0.784216092751413 0.432913323923127 0.901158530199572 Probable transcriptional regulatory protein (LuxR-family) I.J.1 - Repressors/activators Rv2489c - 9 0 0 7.3 6.2 0 1.22916450178676 0.279972716019483 1.95969741516088 0.14286527800339 0.886396581360177 NA Hypothetical alanine rich protein VI - Unknowns Rv2490c PE_PGRS43 3 1.4 1.5 3.4 1.5 1.7 15.6764063704098 0.0788010988296525 0.563943919772033 0.13973215432752 0.888871620151896 NA PE-PGRS family protein PE_PGRS43 IV.C.1.b - PE_PGRS subfamily Rv2491 - 6 5.5 1.7 4.2 8.4 9.1 5.0921630182615 0.485250734714809 0.959176015429341 0.50590374124149 0.612924225806112 NA hypothetical protein VI - Unknowns Rv2492 - 7.9 0.9 2.8 7.3 7.8 23.6 9.51253762793794 1.55178027165753 0.832346217414026 1.86434471520598 0.0622733112028114 NA Hypothetical protein VI - Unknowns Rv2493 vapB38 135.3 57 45.4 175.6 156.6 106.2 37.3803826708537 0.729224916658138 0.38649093327445 1.88678401969215 0.0591893813644078 0.499013258722963 Possible antitoxin VapB38 V - Conserved hypotheticals Rv2494 vapC38 54.8 32.7 25.5 37.5 29.2 44.4 25.1573115416996 -0.196473143281328 0.449287717481735 -0.437299164069214 0.661894401509093 NA Possible toxin VapC38 Contains PIN domain V - Conserved hypotheticals Rv2495c bkdC 226.4 94.8 135.4 177.5 127.5 75.6 262.862919496246 -0.456205052544674 0.262898854496553 -1.73528733481285 0.0826899239335409 0.562041621739757 Probable branched-chain keto acid dehydrogenase E2 component BkdC I.B.2 - Pyruvate dehydrogenase Rv2496c bkdB 162.2 76.2 77.5 126.3 110.3 74.2 172.054010929756 -0.185769062985016 0.233404720177831 -0.795909623607776 0.426084567256835 0.901158530199572 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB I.B.2 - Pyruvate dehydrogenase Rv2497c bkdA 163.2 75.9 91.9 141.9 106.1 102.4 199.557706262525 -0.0946451954545593 0.234332253312338 -0.40389316501134 0.686291282715039 0.942913432418385 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA I.B.2 - Pyruvate dehydrogenase Rv2498c citE 44.7 37.9 26.2 56.6 39.1 25.6 50.0768823092704 0.0132234573024124 0.351989803329751 0.0375677283186081 0.970032338820136 0.998153412295216 Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) I.B.3 - TCA cycle Rv2499c - 56.8 56.7 37 56.4 87.5 55.8 52.4592321929267 0.205186403283424 0.358455434571296 0.572418168324947 0.567038710159589 0.92521033104044 Possible oxidase regulatory-related protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2500c fadE19 171.2 155.4 85.1 121.6 185 172.8 285.69428549149 0.0449929819041076 0.262648389918989 0.17130499797842 0.863983950736575 0.97763538285617 Possible acyl-CoA dehydrogenase FadE19 (MMGC) I.A.3 - Fatty acids Rv2501c accA1 35.7 28.4 18.3 45 35.4 33.4 101.736203413806 0.299578512820553 0.265271886591352 1.12932627980307 0.258760218770621 0.803279666631868 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.A.3 - Fatty acids Rv2502c accD1 31.8 21.5 15 42.6 39.8 25.6 72.6561822311168 0.497080658474881 0.291377776586051 1.70596626928437 0.0880143599582364 0.571985071522678 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 I.A.3 - Fatty acids Rv2503c scoB 34.5 23.6 19.5 40.1 45.2 33.8 33.8083082344917 0.43782963863475 0.387078986323041 1.13111187665805 0.258008006083433 0.802492606810575 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase) I.A.3 - Fatty acids Rv2504c scoA 37.8 25.7 14.7 36.6 35.3 19.7 32.2802697634731 0.0768611878802002 0.400152434403286 0.192079770787393 0.847679720435955 0.975474031954732 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase) I.A.3 - Fatty acids Rv2505c fadD35 5.4 4.7 1.3 6 1.1 4.7 9.30180028102767 -0.085290516300688 0.763560555512264 -0.111701050669737 0.911060446231419 NA Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2506 - 32.9 7.5 11.6 37.7 26.9 14.8 20.3282898890756 0.479567883782217 0.531927044490981 0.901567026435235 0.36728691356917 NA Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv2507 - 128.7 93.5 62 74.1 103.5 123 129.863521738593 -0.102420974030905 0.291624915980551 -0.351207898977108 0.725432384598807 0.949890877982223 Possible conserved proline rich membrane protein II.C.5 - Other membrane proteins Rv2508c - 14.7 5.2 4 12.4 14.5 8.5 19.2329033974212 0.414883423769678 0.518033114748863 0.800882051663454 0.423199931666149 NA Probable conserved integral membrane leucine and alanine rich protein II.C.5 - Other membrane proteins Rv2509 - 160.9 119 91.2 157.3 131.5 88.5 161.016615025992 -0.152245801785067 0.236083201291266 -0.644881977846591 0.519003671620642 0.915911629458156 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2510c - 26.1 26.7 15.6 24.5 31.9 19.4 62.0026082499622 -0.0330293589453726 0.332655024945621 -0.0992901248095439 0.920907918932908 0.99345994686756 hypothetical protein V - Conserved hypotheticals Rv2511 orn 25.2 19.4 3.3 23.5 17 18.8 17.2827150007262 0.194769044917598 0.570988218506709 0.341108692972637 0.733021757234087 NA Oligoribonuclease Orn V - Conserved hypotheticals Rv2512c - 1.8 4.1 1.8 2.7 3 2.3 4.93657734514419 -0.253091945902228 0.982099230009376 -0.257705064996143 0.79663453681079 NA Transposase for insertion sequence element IS1081 IV.B.1.b - IS1081 Rv2513 - 146.7 84 71 76.2 132 133.3 72.8055290092802 -0.0136085364319921 0.337514682724341 -0.0403198353391536 0.967838140322354 0.998153412295216 Hypothetical protein VI - Unknowns Rv2514c - 14.5 3.7 2.3 10.5 8 24.5 6.77505397410366 0.930809245483243 0.910998746546876 1.0217459123972 0.306901174783073 NA hypothetical protein VI - Unknowns Rv2515c - 7.6 0.3 5.6 6.1 3 4.5 8.4247578020761 -0.232954771581799 0.814930034989306 -0.285858615561833 0.774986411634425 NA hypothetical protein VI - Unknowns Rv2516c - 97.3 63 43.1 75.4 87.8 76.7 94.1369032455368 0.0623068170370969 0.271794374678467 0.229242481971181 0.81868045575751 0.967203057682185 Hypothetical protein VI - Unknowns Rv2517c - 259.2 165.1 141 161.2 209 218.5 78.3418249875073 -0.157603851343733 0.304685771159426 -0.517266857405254 0.604969886519107 0.931582271037618 hypothetical protein VI - Unknowns Rv2518c ldtB 45.9 21.9 23.3 43.8 35.3 32.8 65.3140902861372 0.118514824287417 0.302349696414963 0.391979306388192 0.695073503905073 0.943825877173016 Probable L,D-transpeptidase LdtB II.C.1 - Lipoproteins(lppA-lpr0) Rv2519 PE26 95.7 82.3 49.1 96.3 82 68.1 187.00228592717 -0.0528970816669001 0.23161305030713 -0.228385583613514 0.819346495935901 0.967203057682185 PE family protein PE26 IV.C.1.a - PE subfamily Rv2520c - 19.2 22.2 4.1 1.6 20.3 0 3.59766075871199 -1.15226410316023 1.25841929373599 -0.915644021746828 0.359853634165632 NA Possible conserved membrane protein V - Conserved hypotheticals Rv2521 bcp 91.6 39.7 56.9 69.6 66.7 55.4 47.6414486933135 -0.182937732484069 0.34915351293687 -0.523946418139422 0.600315808244271 0.931280721034018 Probable bacterioferritin comigratory protein Bcp III.F - Detoxification Rv2522c - 29.5 17.7 12.7 25.9 17.3 14.7 43.3590977951161 -0.165209125580509 0.35716720354478 -0.46255401935244 0.64368407345444 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv2523c acpS 157.3 64 68.8 156.2 88.1 78.7 62.140488753606 0.0200962183387862 0.334136888738857 0.0601436687060683 0.9520412102932 0.998153412295216 holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase) I.H.1 - Synthesis of fatty and mycolic acids Rv2524c fas 526.8 212.1 221.9 420.7 297 232.9 4575.77511123911 -0.152408952674216 0.200538373437537 -0.759998947142593 0.447255214215503 0.901158530199572 Probable fatty acid synthase Fas (fatty acid synthetase) I.H.1 - Synthesis of fatty and mycolic acids Rv2525c - 140.5 68.7 54.3 100.2 116.2 114.3 112.41884770319 0.161902244013878 0.268479347677363 0.603034257251097 0.546485899889944 0.92521033104044 Conserved hypothetical protein Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system VI - Unknowns Rv2526 vapB17 214.4 122.9 138.7 183.6 192.7 169.3 62.3137043688973 -0.0313659049249646 0.312905205246523 -0.100240917693437 0.920153061967455 0.9932884147079 Possible antitoxin VapB17 V - Conserved hypotheticals Rv2527 vapC17 92.7 71.7 37.8 38 97.2 104.3 47.2376828125882 0.0658142021479789 0.430869664457292 0.152747356282035 0.878597514015803 0.980703859230131 Possible toxin VapC17 V - Conserved hypotheticals Rv2528c mrr 1.9 0 2.6 1.8 3.7 0 2.293409797559 0.160073069055926 1.41489253457418 0.113134436110443 0.909923974176069 NA Probable restriction system protein Mrr II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2529 - 2.4 1.2 0.8 2 1.3 0 2.10831624564382 -0.341116776696223 1.4292129361648 -0.23867456560503 0.811357940537677 NA Hypothetical protein VI - Unknowns Rv2530c vapC39 123.1 69.8 48 109 103.8 96.8 59.8155174761928 0.191248397970295 0.310899089195474 0.615146215015284 0.538458163819541 0.924361123608528 Possible toxin VapC39 Contains PIN domain V - Conserved hypotheticals Rv2530A vapB39 150.3 56 52.1 198.9 140.1 147.1 42.3767442009117 0.751803040818444 0.372840911644485 2.01641777320647 0.0437563085464672 0.418788752385911 Possible antitoxin VapB39 ? Rv2531c - 101.8 60.8 51.2 83.6 85.4 67.2 339.973242608148 -0.028370844789356 0.189313929344289 -0.149861369882405 0.880873989828421 0.980703859230131 Probable amino acid decarboxylase I.A.2 - Amino acids and amines Rv2532c - 129.9 70.7 87.4 95.1 56.2 95.7 58.3637598126025 -0.439292368129464 0.345186694166934 -1.27262254180927 0.203152015649013 0.763476189246154 Hypothetical protein VI - Unknowns Rv2533c nusB 184.4 102.9 102.3 174 113.7 83.3 94.4577279897043 -0.22143980337462 0.284396979104616 -0.778629238861088 0.436198150204145 0.901158530199572 N utilization substance protein NusB (NusB protein) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2534c efp 239.3 130.4 111.2 100.4 204.9 122 136.157894914833 -0.350675617771275 0.291556556763302 -1.2027704732978 0.229065153850998 0.784559243948471 Probable elongation factor P Efp II.A.6 - Protein translation and modification Rv2535c pepQ 133.7 68 47.8 121.1 96 57.6 150.110153192765 0.00789964610180319 0.256831699211142 0.0307580650132633 0.975462483854615 0.998153412295216 Probable cytoplasmic peptidase PepQ II.B.3 - Proteins, peptides and glycopeptides Rv2536 - 91.2 67.9 56.3 66.2 99.2 69.6 84.0998812043233 -0.0830447405929211 0.298600234114892 -0.278113447697325 0.780925273044281 0.963989543249515 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv2537c aroD 233 144.8 103.9 147.4 196.7 152.3 114.765359098008 -0.139743185368098 0.261415239680754 -0.534564035129533 0.592951358608324 0.928941202821899 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) I.D.4 - Aromatic amino acid family Rv2538c aroB 169.4 85.9 97.7 149.1 104.5 92.9 202.767183931889 -0.210050931001606 0.23373972047677 -0.898653128245192 0.368837450493111 0.884059261753852 3-dehydroquinate synthase AroB I.D.4 - Aromatic amino acid family Rv2539c aroK 180.5 101.6 71.4 176.4 109.7 71.8 97.2849385337257 -0.104817747531433 0.294805639312994 -0.355548651564798 0.722178603946246 0.949890877982223 Shikimate kinase AroK (SK) I.D.4 - Aromatic amino acid family Rv2540c aroF 411.2 207 176.6 292.2 224.5 133.5 455.491259067812 -0.44230586866897 0.216074305081258 -2.04700817389015 0.0406572819912622 0.409898801332397 Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) I.D.4 - Aromatic amino acid family Rv2541 - 56.1 12.7 21 60.1 56.6 33.4 24.3547705766191 0.558178726657022 0.474736321636291 1.17576579085655 0.239688480032617 NA Hypothetical alanine rich protein VI - Unknowns Rv2542 - 87.6 54.1 65.7 61.7 68.8 65.6 134.000417417859 -0.316992281772504 0.269224782177992 -1.17742608688576 0.239025482753607 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2543 lppA 14.2 7 10.4 4 16.5 17.2 11.8029009085239 -0.129754767715363 0.70573266856052 -0.183858241931784 0.854124664392695 NA Probable conserved lipoprotein LppA II.C.1 - Lipoproteins(lppA-lpr0) Rv2544 lppB 20.4 13 15.9 4.3 34.7 6.6 16.4355078952377 -0.47345143596015 0.687785229044031 -0.688371043702424 0.491219153664034 NA Probable conserved lipoprotein LppB II.C.1 - Lipoproteins(lppA-lpr0) Rv2545 vapB18 20.4 0 13.8 22 17.3 4.7 5.07216888430994 -0.0237662479816256 1.02362982115947 -0.0232176197785108 0.981476683844971 NA Possible antitoxin VapB18 V - Conserved hypotheticals Rv2546 vapC18 2 0 1.1 1.4 13.2 24.7 4.33733518469658 3.55375047332854 1.4141127956469 2.51306012099469 0.011968893578077 NA Possible toxin VapC18 V - Conserved hypotheticals Rv2547 vapB19 54.8 68.3 20.2 100.4 52 40.5 22.5887156286743 0.350337495672149 0.514046384200542 0.681528956218617 0.495536850988659 NA Possible antitoxin VapB19 V - Conserved hypotheticals Rv2548 vapC19 32 30 3.3 47.6 23.5 33 15.9245536599032 0.656441381151092 0.598591192912909 1.09664390141904 0.272797088360351 NA Possible toxin VapC19 V - Conserved hypotheticals Rv2548A - 257.7 186.4 115.4 148.5 197.4 193.1 110.128081460881 -0.241588717450291 0.279609900410644 -0.864020612630263 0.387576567330152 0.893826103932853 hypothetical protein ? Rv2549c vapC20 34.3 29 12 29.9 19.3 15.5 13.8828283104237 -0.389598814458021 0.594207547769086 -0.655661167416578 0.512042159720742 NA Possible toxin VapC20 VI - Unknowns Rv2550c vapB20 72.1 37.7 32.8 93.8 92.7 124.4 29.1881578880382 0.929624827811167 0.4318615080284 2.15259941098996 0.0313501748782757 0.375387808282729 Possible antitoxin VapB20 VI - Unknowns Rv2551c - 53.7 28.4 31.7 94.2 57.6 44.9 33.331328048878 0.648323083577004 0.406685192709872 1.59416446725543 0.110899202757098 0.647145980645853 hypothetical protein VI - Unknowns Rv2552c aroE 148.7 93.3 80.2 154 60.2 52.7 126.649172979662 -0.438675421476968 0.316399730574613 -1.38645952915412 0.165606629923564 0.725041090026968 Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) I.D.4 - Aromatic amino acid family Rv2553c - 311.7 184 152 207.8 217 187.4 422.59110174678 -0.246563842589393 0.185990694649911 -1.32567837898288 0.184946252005636 0.739746500217031 Probable conserved membrane protein VI - Unknowns Rv2554c - 191.1 91.9 81.7 178.1 107 84 97.40687748927 -0.114727244921232 0.289446788099095 -0.396367310463827 0.691834077941336 0.942913432418385 hypothetical protein VI - Unknowns Rv2555c alaS 591.3 327.8 369.4 429.2 406.7 327.6 1800.64775467944 -0.348073521520193 0.181618099098018 -1.91651340504528 0.0552997785882234 0.487244256658043 Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2556c - 1041.8 565 435.3 646.9 598.4 455.9 384.705927303845 -0.409015400919865 0.188955632155958 -2.16461079383057 0.0304175037023502 0.372277943542923 hypothetical protein V - Conserved hypotheticals Rv2557 - 403.9 241.5 225 235.6 213.2 141.8 265.910197787055 -0.743522659782698 0.209126462183659 -3.55537339473433 0.000377442665980409 0.0217501336271211 hypothetical protein V - Conserved hypotheticals Rv2558 - 339.7 133.4 163.6 225.3 98.8 128.2 204.152968819834 -0.636942213640005 0.283186787974456 -2.24919466828184 0.0245001135455825 0.327036611553196 hypothetical protein V - Conserved hypotheticals Rv2559c - 21.5 10.9 8.6 17.8 11.6 10.4 28.3237426232829 -0.170155523262203 0.425048475622427 -0.400320276441487 0.688920635393073 0.942913432418385 Conserved hypothetical alanine leucine valine rich protein V - Conserved hypotheticals Rv2560 - 5.4 7.1 5.8 2.8 3.8 2.9 7.03195581167026 -1.32838544210537 0.848180327840066 -1.56615922169306 0.117311346604091 NA Probable proline and glycine rich transmembrane protein II.C.5 - Other membrane proteins Rv2561 - 44.9 38.1 21.9 33.9 55 45.6 18.0560301627334 0.116786408049677 0.521899728213993 0.223771735711254 0.822934923924224 NA hypothetical protein VI - Unknowns Rv2562 - 27.3 24.2 12.6 14.8 32.9 18.5 13.1354536408261 -0.189250954292213 0.617637715562474 -0.306410942084172 0.759291778196816 NA hypothetical protein VI - Unknowns Rv2563 - 18.3 18.4 5.3 24.7 14.7 12.1 24.6830579065639 0.21408250068995 0.486103574400114 0.440405115214681 0.659643720776903 NA Probable glutamine-transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv2564 glnQ 24.2 13.4 6.5 37.6 36.1 28.3 36.3024776334879 1.0792146866525 0.391820526301227 2.75435974945022 0.00588070884096782 0.149229730771715 Probable glutamine-transport ATP-binding protein ABC transporter GlnQ III.A.1 - Amino acids Rv2565 - 46.5 37.9 28.4 42.9 64.4 38 121.035469828711 0.157209454697568 0.274137578608185 0.573469188338684 0.566327055474844 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv2566 - 19.3 11.4 7.3 17.4 21.6 12.4 78.8204672587745 0.296172681506673 0.291663828359618 1.01545907551311 0.309887045055669 0.844880251285152 Long conserved protein VI - Unknowns Rv2567 - 65.9 43.6 33.6 59.3 65.4 49.4 223.325443448794 0.109340931797046 0.209737392856542 0.521323023557532 0.602141764881174 0.931398768888358 Conserved hypothetical alanine and leucine rich protein V - Conserved hypotheticals Rv2568c - 16.6 8.4 8.3 14 19 5.5 18.6537402907769 0.0271575000864293 0.516560924729896 0.052573663214324 0.95807160165164 NA hypothetical protein V - Conserved hypotheticals Rv2569c - 13.9 10.9 7.5 12.6 13.4 8.2 16.3456456944672 -0.142341460378025 0.533023039085981 -0.267045605799909 0.789434047334502 NA hypothetical protein V - Conserved hypotheticals Rv2570 - 16.4 4.4 2.5 8.5 4.7 7.3 3.34541025843398 -0.388752505715947 1.17887101164699 -0.329766786930169 0.741576185009209 NA hypothetical protein VI - Unknowns Rv2571c - 15.1 11.6 8.3 27.3 22.3 15.5 27.1941105274914 0.742156982076567 0.429394638028867 1.72837971494808 0.0839201698403904 0.562041621739757 Probable transmembrane alanine and valine and leucine rich protein V - Conserved hypotheticals Rv2572c aspS 30.1 21 11.5 29.8 28.3 22.1 66.4998955516161 0.207905717717749 0.301438672857081 0.689711495035417 0.49037563559396 0.91093284624103 Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2573 - 6.8 7 3.2 8.1 5.9 7.6 7.10348534775245 0.140099445759172 0.794146818219296 0.176415043849594 0.859967886731804 NA hypothetical protein VI - Unknowns Rv2574 - 103 68.1 63.5 99.4 78.1 65.1 64.1037848363371 -0.131402907128233 0.306594064811847 -0.428589207063984 0.668222201351954 0.940354944889996 hypothetical protein VI - Unknowns Rv2575 - 53.5 20.1 19.4 31.8 40.4 40.6 47.1233660304322 0.108752149403302 0.369012067162715 0.294711634336195 0.768214174806485 0.960872935483437 Possible conserved membrane glycine rich protein V - Conserved hypotheticals Rv2576c - 1240 827.9 464.7 663.9 1242 1259.9 707.272405345329 0.224613256915965 0.275505386459821 0.815277188595808 0.414913663130397 0.901158530199572 Possible conserved membrane protein VI - Unknowns Rv2577 - 6.2 4.3 3.4 5 0 5.7 10.3163885789964 -0.514000311389171 0.742998027252026 -0.691792296259787 0.489067775237888 NA hypothetical protein VI - Unknowns Rv2578c - 14.2 10.1 8.3 19.3 19.9 8.3 21.3008443287679 0.389250700237745 0.478712047502925 0.813120752377485 0.416148829360704 NA hypothetical protein VI - Unknowns Rv2579 dhaA 51.9 26.8 19.3 42.8 37.4 24.2 46.6419419589274 -0.0592648824433032 0.347843667554944 -0.170377925405073 0.864712931293651 0.97763538285617 Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2580c hisS 157.5 84.4 87.4 133.5 100 99.6 224.478319767808 -0.161623611718858 0.219087076294929 -0.737714037962168 0.460688239746917 0.901158530199572 Probable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2581c - 144.4 90.6 102.1 131 141.3 80 125.211570656421 -0.157635668246274 0.266237278914475 -0.59208713704181 0.553792239936486 0.92521033104044 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) III.F - Detoxification Rv2582 ppiB 26.3 20.7 18.3 27.8 28.1 28.8 37.0357083698286 0.154723219282981 0.3834350425967 0.403518724410695 0.686566662884719 0.942913432418385 Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase) II.A.6 - Protein translation and modification Rv2583c relA 145 82.9 58.8 148.4 104.8 100 396.343961568587 0.160860870644935 0.199330617512912 0.807005329397102 0.419663412713638 0.901158530199572 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2584c apt 131.1 52.6 73.1 161.3 81.1 90.5 103.493338004882 0.199356758724427 0.304803332227044 0.654050456954746 0.513079298637534 0.915911629458156 Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) I.F.4 - Salvage of nucleosides and nucleotides Rv2585c - 92.9 48.9 61.4 97 78.9 79.8 206.010911992189 0.128082039551655 0.235295314281772 0.544345899715937 0.586203466953528 0.928941202821899 Possible conserved lipoprotein V - Conserved hypotheticals Rv2586c secF 239.6 147.2 106 188.8 142.6 133.8 337.193823462886 -0.236862799490169 0.196206233633746 -1.20721342591141 0.227349961249636 0.780210909201606 Probable protein-export membrane protein SecF III.D - Protein and peptide secretion Rv2587c secD 241.9 162 148.9 144.4 227.7 145.9 499.89243306659 -0.299127581232053 0.224066600156427 -1.33499406436847 0.18187828914037 0.736194517318001 Probable protein-export membrane protein SecD III.D - Protein and peptide secretion Rv2588c yajC 311.3 235.4 196.8 264.2 259.5 181.9 136.200346626033 -0.274839764136893 0.245718895676117 -1.11851293886311 0.263347983551096 0.807561554880633 Probable conserved membrane protein secretion factor YajC V - Conserved hypotheticals Rv2589 gabT 111.7 72.5 56.3 91.8 77.3 74.6 174.470640876732 -0.149572952936343 0.220981616433406 -0.676856995393633 0.498496691745911 0.914958095135494 4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at) I.C.1 - General Rv2590 fadD9 870 522.3 464.6 418.4 525.7 388.2 3028.76470570064 -0.651505246757245 0.175347680706411 -3.71550535560306 0.000202797969612931 0.0136814435109602 Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2591 PE_PGRS44 93.3 69.6 45.6 75.7 81.3 55.2 182.610534463051 -0.143269449846187 0.224754882733188 -0.637447552212982 0.523833362610696 0.919951162527736 PE-PGRS family protein PE_PGRS44 IV.C.1.b - PE_PGRS subfamily Rv2592c ruvB 72 35 23.5 87.3 53.9 46.4 83.7221526183829 0.412056339792992 0.304156167581387 1.35475253738767 0.175496413021301 0.734764437650925 Probable holliday junction DNA helicase RuvB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2593c ruvA 63.9 32.1 34.3 82.6 70.6 27.7 46.8792491421124 0.309239405066612 0.369500349128201 0.836912348787306 0.402641838575681 0.893826103932853 Probable holliday junction DNA helicase RuvA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2594c ruvC 98.9 75.2 54.4 106.4 91.5 35.1 68.533306073518 -0.148228438669452 0.330637734282616 -0.44831071381209 0.653928969523759 0.939577115195416 Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2595 vapB40 216.3 173.8 89.1 281.5 240.5 224.4 78.8502130836884 0.491129984028169 0.289548271237091 1.69619380537077 0.0898491832203731 0.577960094854772 Possible antitoxin VapB40 V - Conserved hypotheticals Rv2596 vapC40 64.3 50.1 26.7 60.9 69.5 84.7 37.9402525241592 0.450822289007866 0.393193163460075 1.14656695716848 0.251560639415811 0.796128980119145 Possible toxin VapC40 Contains PIN domain V - Conserved hypotheticals Rv2597 - 46.4 47.1 30.7 41.8 60.7 38.7 44.5560240862461 -0.00812382379248823 0.374969905023234 -0.0216652688220002 0.982714968731014 0.998667985896356 Probable membrane protein VI - Unknowns Rv2598 - 16.1 12.7 13.9 7.1 7.7 23.1 10.7471973293893 -0.649387125484217 0.721839588758515 -0.899628027608033 0.368318236561223 NA hypothetical protein VI - Unknowns Rv2599 - 19 17.5 5 7.6 20.8 10.6 8.5415255337373 -0.362556208971964 0.77461162904584 -0.468049013695493 0.639749539380053 NA Probable conserved membrane protein V - Conserved hypotheticals Rv2600 - 99.7 56.9 38.8 80.7 89 54.1 43.3023089139518 0.0254256511270033 0.353858606853565 0.0718525722832708 0.942719234271092 0.998153412295216 Probable conserved integral membrane protein V - Conserved hypotheticals Rv2601 speE 14.1 6.6 9.5 15.9 15.9 2.4 26.1530484243508 -0.011529286732008 0.491021541487723 -0.0234802055671039 0.981267227801506 NA Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) I.E - Polyamine synthesis Rv2601A vapB41 157 71.9 66.5 125.4 139 94.6 48.8567409433714 0.11808065901468 0.338357026581803 0.348982434937351 0.727102496455749 0.949890877982223 Possible antitoxin VapB41 ? Rv2602 vapC41 147.7 72.9 50.8 149.9 155.2 69.5 72.1949588146128 0.339063033302197 0.314038402813748 1.07968652962259 0.280281794359539 0.822522870982296 Possible toxin VapC41 Contains PIN domain V - Conserved hypotheticals Rv2603c - 115.6 73 72.4 132.6 88.3 70.5 111.209659656866 -0.023101581183942 0.271107865192343 -0.0852117704794439 0.932093033128407 0.998010361628995 Highly conserved protein V - Conserved hypotheticals Rv2604c snoP 66.5 25.7 39.1 67.9 70.3 27.4 45.3640887183362 0.144640563691331 0.380809146715089 0.379824289776177 0.704075850567964 0.94870036274315 Probable glutamine amidotransferase SnoP V - Conserved hypotheticals Rv2605c tesB2 185.3 132.2 90.9 149 118.9 163.1 191.116619913122 -0.091884214820948 0.243145575540562 -0.377897951121137 0.705506404553769 0.949622474147298 Probable acyl-CoA thioesterase II TesB2 (TEII) I.H.1 - Synthesis of fatty and mycolic acids Rv2606c snzP 178.7 92.2 62.7 140.5 101.5 100.4 157.937115906105 -0.0834265445607184 0.243420888307182 -0.342725495502421 0.731804980485291 0.951379060695889 Possible pyridoxine biosynthesis protein SnzP V - Conserved hypotheticals Rv2607 pdxH 2.4 0 4.2 2.6 9.4 1 3.04476556011152 0.459159906126565 1.29959196273898 0.353310823159336 0.723855432392033 NA Probable pyridoxamine 5'-phosphate oxidase PdxH (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) I.G.6 - Pyridoxine Rv2608 PPE42 27.1 10.2 13.8 27.8 18.1 19.1 52.521823990283 0.172460951172549 0.344751285680708 0.500247448916767 0.616900851864479 0.931582271037618 PPE family protein PPE42 IV.C.2 - PPE family Rv2609c - 144 100.2 66.9 153.6 110.6 94.3 186.065426175743 0.0481446549754602 0.227599058356584 0.211532751159414 0.832471578631305 0.969702342452218 Probable conserved membrane protein V - Conserved hypotheticals Rv2610c pimA 120.3 76 56.7 142.8 80.4 58.6 158.654206812994 0.000804235149138867 0.267209784018569 0.00300975187750977 0.997598569070691 0.999833281786427 Alpha-mannosyltransferase PimA IV.H - Miscellaneous transferases Rv2611c - 72.1 32.7 31.2 67.9 36 30.4 66.48659024604 -0.148575390133685 0.331832280252455 -0.447742425844315 0.654339099042316 0.939577115195416 Probable acyltransferase V - Conserved hypotheticals Rv2612c pgsA1 58.6 31.5 39.3 84.7 27.5 55.9 51.5373734734709 0.193925364661915 0.392648086959651 0.493891021253958 0.621383145998664 0.931582271037618 PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglycerol--inositol-3-phosphatidyltransferase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2613c - 102.9 55.6 61.7 76.7 56.2 64.1 65.7354395424834 -0.356720797888596 0.310817177972447 -1.14768688209446 0.251097848433224 0.796128980119145 hypothetical protein V - Conserved hypotheticals Rv2614c thrS 68.3 50.6 41 67.1 46.1 47.4 179.108830588947 -0.184217504142458 0.234877907633952 -0.784311755831687 0.432857203144262 0.901158530199572 Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2614A - 1 0 0 0.3 0 0 0.0448007840762574 -0.318231606298853 4.0267484609073 -0.0790294227186839 0.937009220301446 NA hypothetical protein ? Rv2615c PE_PGRS45 34 21.2 12 41.2 6.7 28 51.1769035915157 0.0642952318741031 0.451230116558366 0.142488786795743 0.886693935841791 0.982421186038534 PE-PGRS family protein PE_PGRS45 IV.C.1.a - PE subfamily Rv2616 - 72.3 23.6 36.5 74.8 47.1 29.7 36.067639097394 0.0351247316647347 0.416863966005514 0.084259457590705 0.932850145884151 0.998010361628995 hypothetical protein VI - Unknowns Rv2617c - 54.4 25.6 14 36.7 19.3 19.6 18.3542627102886 -0.378717095562906 0.537762789303711 -0.70424563226709 0.481279817693627 NA Probable transmembrane protein VI - Unknowns Rv2618 - 20.4 7.9 7.8 17.4 13 21 15.2424972492703 0.304312432632175 0.562695420231864 0.540811994714264 0.588637174455256 NA hypothetical protein V - Conserved hypotheticals Rv2619c - 54.2 48.2 49.1 41.1 43.6 46.2 27.3771168675125 -0.522195825228102 0.454913316480075 -1.14790182285414 0.25100909561664 0.796128980119145 hypothetical protein VI - Unknowns Rv2620c - 25.1 27 9.7 25.9 27.6 11.9 13.983854532755 -0.0243444213821162 0.590870953806951 -0.0412009106646153 0.967135727685378 NA Probable conserved transmembrane protein V - Conserved hypotheticals Rv2621c - 62.5 26.2 34.3 53.7 32.3 25.2 41.5610081532488 -0.300757676275379 0.382331891118922 -0.786640307182301 0.431492456778055 0.901158530199572 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2622 - 15.5 6 2.6 9.4 10.4 0 8.19396092024505 -0.296586593154439 0.809219557115535 -0.366509423241849 0.713984982340233 NA Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2623 TB31.7 2430.4 941.3 2260.1 356.6 10.3 149.1 1628.91147848208 -3.74357462315189 1.17659733673782 -3.18169564579431 0.00146415593899723 0.0617257760107824 Universal stress protein family protein TB31.7 V - Conserved hypotheticals Rv2624c - 300.3 128.9 228.2 43.4 0 18.8 170.366434635381 -3.64364029795048 1.35306744268319 -2.6928741192124 0.00708390093772582 0.167470683707262 Universal stress protein family protein V - Conserved hypotheticals Rv2625c - 505.1 182.1 389.2 62.3 6.3 29.6 400.966120074775 -3.71519870196363 0.892029307473664 -4.16488412525988 3.11510737441129e-05 0.00287212899920721 Probable conserved transmembrane alanine and leucine rich protein V - Conserved hypotheticals Rv2626c hrp1 1433 671.7 1306.2 110.5 0 109.6 467.809231329962 -4.19371451987644 1.50449967917884 -2.78744793230223 0.00531249906244199 0.140727431742496 Hypoxic response protein 1 Hrp1 V - Conserved hypotheticals Rv2627c - 828.4 268.5 764.6 118.2 11.8 73.4 757.037387073557 -3.45574262804795 0.943477977678994 -3.6627697835081 0.000249502757305633 0.0160473047435909 hypothetical protein V - Conserved hypotheticals Rv2628 - 406.8 148.4 411.6 50 36.3 12.5 114.743941366283 -3.64641742286442 0.705093385832705 -5.17153826164184 2.32174718776094e-07 4.28130181423117e-05 Hypothetical protein VI - Unknowns Rv2629 - 1584.2 630 1195.6 378.2 179.7 279.4 1360.08556265779 -2.24044141478273 0.290873257730568 -7.70246612652861 1.33465004489978e-14 6.152736706988e-12 hypothetical protein VI - Unknowns Rv2630 - 733.5 328.7 476.7 174.6 67 114.9 286.822033042579 -2.30346726554106 0.298460631710005 -7.71782614123525 1.18330452852095e-14 6.152736706988e-12 Hypothetical protein VI - Unknowns Rv2631 - 311.6 136.5 202.9 67 27.6 29.1 282.227103210726 -2.56876184353879 0.302966396192216 -8.47870217893422 2.27719757594838e-17 3.14936424753661e-14 hypothetical protein V - Conserved hypotheticals Rv2632c - 92 62.2 28.3 81.7 90.7 102.9 33.7792212824296 0.43834923218965 0.410834942002129 1.0669716408576 0.285984642132407 0.829758572569927 hypothetical protein V - Conserved hypotheticals Rv2633c - 128.4 69.7 63.1 79.8 113.6 100.8 71.0792915872382 -0.0373605350996063 0.311288136290184 -0.120019142216132 0.90446798427021 0.991208909356546 Hypothetical protein VI - Unknowns Rv2634c PE_PGRS46 7.5 2.8 4.4 8 5.3 5 19.4958951737489 0.131466235697908 0.502900942697864 0.261415767074613 0.793771899302102 NA PE-PGRS family protein PE_PGRS46 IV.C.1.b - PE_PGRS subfamily Rv2635 - 0 0 0 2.8 0 10.4 0.654683819798815 2.64429330730433 2.6660287815573 0.991847246960223 0.321272045964789 NA Hypothetical protein VI - Unknowns Rv2636 - 7.2 2.5 4.7 7.2 5.4 4.6 4.93040405956879 -0.0748037137879859 0.943846487257593 -0.07925411049135 0.936830505955738 NA hypothetical protein VI - Unknowns Rv2637 dedA 23.1 20.7 8.8 30.8 27.4 41.8 26.575888095778 0.770915216817312 0.458124832034532 1.68276234534958 0.0924211071263281 NA Possible transmembrane protein DedA V - Conserved hypotheticals Rv2638 - 22 8.4 8.7 13.7 23.5 7.8 9.23415882719562 0.0217439611538263 0.707259034363271 0.0307439850144889 0.975473712757829 NA hypothetical protein V - Conserved hypotheticals Rv2639c - 58.7 35 14.2 54.7 34.4 18.8 17.5315574334738 -0.0956360515494754 0.552622323926639 -0.173058610571388 0.862605357982966 NA Probable conserved integral membrane protein V - Conserved hypotheticals Rv2640c - 242.3 139.2 159.4 183.7 172.6 238.7 111.412875382984 -0.0771085814952059 0.287980828867772 -0.26775595375 0.788887176872042 0.963989543249515 Possible transcriptional regulatory protein (probably ArsR-family) I.J.1 - Repressors/activators Rv2641 cadI 245.2 175 104.1 167 158 167.2 124.355267598123 -0.252810319194303 0.254739711712757 -0.992426023781366 0.320989749434853 0.849868688356633 Cadmium inducible protein CadI V - Conserved hypotheticals Rv2642 - 38.2 11.2 28.3 54.1 29.4 4.9 16.1530720559146 0.0519306328721215 0.622374376047976 0.0834395419713076 0.933502048169778 NA Possible transcriptional regulatory protein (probably ArsR-family) I.J.1 - Repressors/activators Rv2643 arsC 11.4 3.5 6.5 10.4 12 7.9 19.7400012024674 0.241495059598122 0.502202193025698 0.48087217250715 0.630607351514557 NA Probable arsenic-transport integral membrane protein ArsC III.A.4 - Anions Rv2644c - 17.8 13.7 17.3 11.1 8.7 7.4 6.30996893175336 -1.19473715559612 0.872687592845682 -1.36903190258531 0.17098930278823 NA Hypothetical protein VI - Unknowns Rv2645 - 47.4 19.4 23.6 21.7 19.9 13.1 16.0550905519315 -0.927276060579243 0.55158310584744 -1.68111758817304 0.0927400767475179 NA Hypothetical protein VI - Unknowns Rv2646 - 18.8 9.9 13.2 8.5 7.4 11.3 18.4077662788666 -0.962185212662677 0.533608274223246 -1.80316771523698 0.0713618791077996 NA Probable integrase IV.B.3 - Phage-related functions Rv2647 - 50.5 16.3 24.6 15.9 31.6 15.3 14.4151763532987 -0.81903737568877 0.605930706418216 -1.35170138600546 0.176470861517055 NA Hypothetical protein IV.B.3 - Phage-related functions Rv2648 - 12.7 10.7 9.9 14.1 14.5 0 5.15365386511554 -0.353200121403197 0.941783684836244 -0.3750331706634 0.707635797447683 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2649 - 6.5 2.9 1.5 2.7 5.1 2.9 4.61800840551401 -0.302656512668115 0.980752177482511 -0.308596319862377 0.757628620644647 NA Probable transposase for insertion sequence element IS6110 IV.B.1.a - IS6110 Rv2650c - 98.2 47.7 48.5 66.2 42.7 34.8 128.65053548006 -0.585456697717568 0.263687970642875 -2.22026320082109 0.0264009063599683 0.342839938928039 Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2651c - 121.4 60.4 59.7 110.7 62.5 30.4 61.6499657789918 -0.376005576489137 0.359892420150155 -1.04477214699954 0.296128290844068 0.837161771605085 Possible PhiRv2 prophage protease IV.B.3 - Phage-related functions Rv2652c - 12.2 13.1 3.4 8.3 13.1 2.3 7.93146954488706 -0.536477367795938 0.812768073382876 -0.660062058740853 0.50921400535098 NA Probable PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2653c - 4.9 0.4 6.5 3.9 5.5 2.1 1.5645244488067 -0.876079190040023 1.70025050516394 -0.515264772678631 0.606368011905955 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2654c - 2.7 0 5.2 2.6 4.3 0 0.975718768491528 -0.616635099480403 2.08647224944323 -0.295539564278869 0.767581733384971 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2655c - 2.9 4.6 1.3 1.3 3.2 2 5.287440033681 -0.762557001053559 0.974858743573256 -0.78222307188678 0.43408348760311 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2656c - 6.6 5.1 2.7 2 6.6 5.2 2.61394268650273 -0.467910586879291 1.31181393928589 -0.356689750631867 0.721324079314416 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2657c - 87.2 25.4 18.5 39.2 107.7 14.2 18.2068268886911 0.186104520337694 0.620288998091685 0.300028730011725 0.764155241163718 NA Probable PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2658c - 27.6 4.7 15.1 22.9 29.8 0 8.63918184805869 0.0220547647890797 0.806316377852345 0.0273524951183845 0.978178587460519 NA Possible prophage protein IV.B.3 - Phage-related functions Rv2659c - 7.7 0 2.3 3.1 4.5 2.4 4.78292470301227 -0.27526402478419 1.03266642002048 -0.26655657572242 0.789810593712966 NA Probable PhiRv2 prophage integrase IV.B.3 - Phage-related functions Rv2660c - 0.1 0 0 0 1.3 0 0 NA NA NA NA NA Hypothetical protein VI - Unknowns Rv2661c - 6 9 3 5.1 4.5 2.8 2.42824113150827 -0.854582164623767 1.37266070316248 -0.622573490051031 0.533564836475826 NA Hypothetical protein VI - Unknowns Rv2662 - 11 0 0 0 0 0 0.582410192991346 -2.45556463192539 3.00754005856795 -0.816469468105643 0.414231679065819 NA Hypothetical protein VI - Unknowns Rv2663 - 46.5 50.2 84.4 30.8 84.8 88.2 25.8006418918718 -0.220548438734844 0.578979596978321 -0.380926098062661 0.7032580864212 NA Hypothetical protein VI - Unknowns Rv2664 - 34.4 28.5 17.6 23.4 35.9 27.4 11.3037747475087 -0.155164867804136 0.642551307882389 -0.241482455798748 0.809181212448732 NA Hypothetical protein VI - Unknowns Rv2665 - 572.4 325.4 338.5 324.4 295 386.3 172.522674868806 -0.491166235783185 0.252387005718953 -1.94608369152779 0.0516446872562964 0.466827467159856 Hypothetical arginine rich protein V - Conserved hypotheticals Rv2666 - 4.8 4.5 3.4 1.4 2.3 3.5 3.78472863417528 -1.64943421932971 1.15150954027648 -1.43241038101489 0.152026409350473 NA Probable transposase for insertion sequence element IS1081 (fragment) IV.B.1.b - IS1081 Rv2667 clpC2 5.9 2.3 1.8 0.9 0 10.3 3.88047570713904 -0.184807872588576 1.24144058434871 -0.148865660522553 0.88165963816608 NA Possible ATP-dependent protease ATP-binding subunit ClpC2 II.B.3 - Proteins, peptides and glycopeptides Rv2668 - 29.2 24.1 12 21.6 15.3 18.4 16.258369251388 -0.395565160159695 0.542961474212496 -0.728532647244295 0.466287591275126 NA Possible exported alanine and valine rich protein VI - Unknowns Rv2669 - 27.9 18.9 6.7 15.7 25.7 13.9 12.1089386510805 -0.149265289035489 0.63658307966711 -0.234478882337785 0.814613225718536 NA GCN5-related N-acetyltransferase I.J.1 - Repressors/activators Rv2670c - 8.4 10.9 1.9 9.9 9.3 10.2 14.1826340138398 0.370678010095262 0.608840773027108 0.608825864687544 0.542639867690143 NA hypothetical protein V - Conserved hypotheticals Rv2671 ribD 25.7 17.7 11.5 24.4 21.4 14.6 22.9356780217229 0.00701721065188589 0.457215671274018 0.0153477037047585 0.98775478490292 NA Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase) I.G.9 - Riboflavin Rv2672 - 49.3 36.4 30.5 49.1 41.8 40.4 105.241363643535 -0.0177490086051024 0.261738159100357 -0.0678120785525087 0.945935228602502 0.998153412295216 Possible secreted protease II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2673 aftC 28.4 19.2 13.2 25 20.7 29.6 46.8817574437476 0.12232869302714 0.352356680523641 0.347172906854912 0.728461423673929 0.949890877982223 Possible arabinofuranosyltransferase AftC II.C.5 - Other membrane proteins Rv2674 msrB 186.7 169.3 109.7 129.6 173.9 108.9 97.8846310396591 -0.383685942143459 0.286888329755546 -1.33740519340886 0.18109041015062 0.735038480974451 Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase) V - Conserved hypotheticals Rv2675c - 132.9 80.8 53.6 101.5 77.1 81.1 103.877026874036 -0.18773423304788 0.262065019240285 -0.716365097456016 0.473765940429427 0.904373078832156 hypothetical protein IV.H - Miscellaneous transferases Rv2676c - 168.5 109.2 76.4 136.5 160.7 78.8 132.976368713686 -0.0755216669388807 0.25309228196866 -0.298395772290806 0.765401115403098 0.959593750764785 hypothetical protein V - Conserved hypotheticals Rv2677c hemY 77.9 31.9 30.7 66.4 51.7 33.3 101.284302456653 -0.0197502479782158 0.283663168953364 -0.0696257044969516 0.944491577354167 0.998153412295216 Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) I.G.12 - Heme and porphyrin Rv2678c hemE 96.1 57.4 47.6 96.4 74.6 54.6 120.145886348772 0.00866787096064797 0.250355992569912 0.0346221828831497 0.97238101271929 0.998153412295216 Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD) I.G.12 - Heme and porphyrin Rv2679 echA15 97.6 49.9 46.6 74.4 51.6 51 81.041469310021 -0.303755975169776 0.285697158108734 -1.06320964891841 0.287686887652958 0.829758572569927 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2680 - 123 74.4 64.5 151 115.7 107.7 105.974317643323 0.35305229195404 0.255484773672522 1.38189171463729 0.167004952326036 0.725041090026968 hypothetical protein V - Conserved hypotheticals Rv2681 - 69.6 45.1 37.9 79.8 58.6 31.8 111.201227421122 -0.0124002977895158 0.279096039402032 -0.0444302176988382 0.964561475184388 0.998153412295216 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2682c dxs1 232.9 150.7 115.3 257.3 169 121.1 527.597635741594 -0.0505906867470347 0.211464064109752 -0.239240113728154 0.810919399357005 0.966073477417693 Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv2683 - 21.5 22.8 16 19.1 24.4 25.2 17.4682987049759 -0.0556643246509418 0.542255949787557 -0.102653229849759 0.918238194636173 NA hypothetical protein V - Conserved hypotheticals Rv2684 arsA 39.3 23.2 16.5 37.5 51.1 38.1 68.9485819758694 0.49089092256545 0.305895041236271 1.60476914101491 0.108544619513884 0.643080319504058 Probable arsenic-transport integral membrane protein ArsA III.A.4 - Anions Rv2685 arsB1 47.1 26.2 17.3 50.1 36.3 38 71.2806297552616 0.321558756054903 0.299010650784972 1.07540903713877 0.282191637526382 0.825259204787765 Probable arsenic-transport integral membrane protein ArsB1 III.A.4 - Anions Rv2686c - 33 17.1 11.4 13.7 18.2 25.9 23.3788135387887 -0.327534343007228 0.490112670530981 -0.66828376963277 0.503952471618247 NA Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter II.C.5 - Other membrane proteins Rv2687c - 17 11.8 5.5 11.2 0 10.3 10.4294974423004 -0.793131462616456 0.744183546680991 -1.06577398298279 0.286525824505733 NA Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter VI - Unknowns Rv2688c - 81.2 27.3 25 33.7 41.9 40 57.7642530595058 -0.344078944784458 0.356070596351075 -0.966322263928825 0.333882948789581 0.853347384539607 Antibiotic-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2689c - 11.7 11.3 4.2 20.9 18.2 16.2 25.792633177651 0.898837104744571 0.447326275387037 2.00935459015207 0.0444995423625673 NA Conserved alanine and valine and glycine rich protein IV.H - Miscellaneous transferases Rv2690c - 10.7 7.4 9 16.2 15.5 14.5 38.2961741490692 0.54061530864728 0.384630168265495 1.40554577683078 0.159859047008301 0.713177619395098 Probable conserved integral membrane alanine and valine and leucine rich protein II.C.5 - Other membrane proteins Rv2691 ceoB 62.6 40.1 22 47.4 49.3 51.4 48.4316974768716 0.0785628393725301 0.346612520851807 0.226658976944804 0.820688928553901 0.967203057682185 TRK system potassium uptake protein CeoB III.A.2 - Cations Rv2692 ceoC 56.5 25.6 29.6 74.8 38.4 50.7 47.0739730491549 0.37748152427748 0.365017932086714 1.03414515040265 0.301068311423128 0.842296632810805 TRK system potassium uptake protein CeoC III.A.2 - Cations Rv2693c - 70.7 29.2 31.2 63.2 35.5 46.1 48.2367089859324 -0.00800788006593713 0.357072119723932 -0.0224265060854608 0.982107736867745 0.998667985896356 Probable conserved integral membrane alanine and leucine rich protein V - Conserved hypotheticals Rv2694c - 123.8 65.5 45 163.6 119.4 148.2 63.2360423057933 0.738639596428275 0.319004288815268 2.31545349804376 0.0205881266491222 0.297479746745841 hypothetical protein V - Conserved hypotheticals Rv2695 - 16.5 4.4 4.5 8.7 5.2 16 9.77184453300077 -0.0889141106469988 0.72614771168936 -0.122446313905119 0.902545561242868 NA Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2696c - 224.7 86.7 85.7 168.4 154.8 119.3 168.754227272064 0.0262202223314651 0.243655328387811 0.107611938983464 0.914303526052757 0.9932884147079 Conserved alanine and glycine and valine rich protein V - Conserved hypotheticals Rv2697c dut 491.7 305.5 240.5 450.5 332.1 286.2 259.285728353581 -0.11873773373062 0.206916951295024 -0.573842466687625 0.56607440866007 0.92521033104044 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv2698 - 26 13.8 11 36.3 10.1 17.5 14.1041335221605 0.255939178542029 0.609164807853203 0.420147676363644 0.674377575715906 NA Probable conserved alanine rich transmembrane protein V - Conserved hypotheticals Rv2699c - 27.7 0 15.9 36.1 22.8 0 7.52167444756912 0.305214172931148 0.902509851778626 0.338183757584082 0.735224715104478 NA hypothetical protein V - Conserved hypotheticals Rv2700 - 59 38.1 21.8 47.1 70.1 23.9 43.2990433125661 0.115049999044326 0.379282169083246 0.303336166111923 0.761633687157843 0.959593750764785 Possible conserved secreted alanine rich protein V - Conserved hypotheticals Rv2701c suhB 21.9 9.9 8.6 24.6 20.1 6.5 19.5619889886544 0.219022689873113 0.517686733256049 0.42307958810446 0.672237194381216 NA Inositol-1-monophosphatase SuhB III.B - Chaperones/Heat shock Rv2702 ppgK 100.9 74.4 35.1 82.1 82.2 74.6 94.1744953470428 0.0494547649418502 0.282517444346245 0.175050305499861 0.861040105708139 0.976194404037999 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) I.A.1 - Carbon compounds Rv2703 sigA 371.6 175.2 201.2 259.3 263.9 213.7 628.123019240573 -0.193736777779741 0.193883226458008 -0.999244655244589 0.317676188553714 0.847340730510678 RNA polymerase sigma factor SigA (sigma-A) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2704 - 116.4 71.2 46 97.4 161.8 99.2 65.82923833357 0.45644095229202 0.326395754260368 1.39842797075085 0.16198458858937 0.718349182700872 hypothetical protein V - Conserved hypotheticals Rv2705c - 36.7 37.5 20.5 21.8 50.2 49.7 22.5746354854918 0.102025515167414 0.5246738192541 0.194455128926497 0.845819526983556 NA hypothetical protein VI - Unknowns Rv2706c - 9.5 3.9 5.7 3 8.6 13.4 3.02315124859798 0.025202252754118 1.23960692795442 0.0203308421288887 0.983779452406954 NA Hypothetical protein VI - Unknowns Rv2707 - 128.4 91.5 52.8 122.5 138.2 128.5 170.150675582809 0.354511328006846 0.239821742196694 1.47822847403088 0.139346634938851 0.682181933169668 Probable conserved transmembrane alanine and leucine rich protein V - Conserved hypotheticals Rv2708c - 595.3 391.5 242.8 410.4 554.3 548.6 181.462562235274 0.146447696871169 0.256027702298357 0.571999418643024 0.567322368507687 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv2709 - 236.1 145.7 110.2 124.7 192.8 124.4 110.432183840956 -0.344073185134555 0.273576774203759 -1.25768419536335 0.208505990258217 0.770341510876847 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2710 sigB 537.4 296.7 281.1 416 456.4 344.8 603.105073497275 -0.0455641497465925 0.181342350823601 -0.251260389752609 0.801612797375406 0.965592404376002 RNA polymerase sigma factor SigB II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2711 ideR 685.3 427.7 383.2 712.5 713.7 473.3 623.702438877866 0.153553603971727 0.181253555563107 0.847175678814554 0.396897207682534 0.893826103932853 Iron-dependent repressor and activator IdeR I.J.1 - Repressors/activators Rv2712c - 21.7 16.7 9.1 16.3 17.6 13.6 26.2879336479419 -0.197764876725294 0.43382222872531 -0.455866167361644 0.648486219768635 NA Hypothetical protein VI - Unknowns Rv2713 sthA 95.4 54.5 40.7 80.4 78.2 56.4 149.28449691255 0.0154629904968607 0.230079310628865 0.0672072184786907 0.946416738604784 0.998153412295216 Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2714 - 139.5 84.3 70.4 108.2 128.2 104.9 164.604505048594 0.0343068321737132 0.230936648050335 0.148555166377212 0.881904652397308 0.980892105790941 Conserved alanine and leucine rich protein V - Conserved hypotheticals Rv2715 - 248.2 183.1 120.9 227.9 245.5 199.4 334.305546504458 0.115160398958257 0.199678156697862 0.576730078355586 0.564121810227204 0.92521033104044 Possible hydrolase II.B.6 - Aromatic hydrocarbons Rv2716 - 128.5 120.7 87.1 58.6 185.4 89.1 126.022080809906 -0.252966394966581 0.358801525242853 -0.705031548556996 0.480790603142449 0.907292899730371 hypothetical protein V - Conserved hypotheticals Rv2717c - 32.8 18.1 3.4 39.8 26.3 31.2 18.2474032836225 0.796032769164354 0.571540218104853 1.39278522131634 0.163684748742504 NA hypothetical protein V - Conserved hypotheticals Rv2718c nrdR 78.1 50.2 20.5 118.9 42.6 37.4 40.0603938374744 0.349192910423034 0.446395882101489 0.782249398850064 0.434068018332461 0.901158530199572 Probable transcriptional regulatory protein NrdR V - Conserved hypotheticals Rv2719c - 61.4 21.8 37.7 72.1 47.1 45 37.105372042644 0.26341500834969 0.397698984192224 0.662347702206779 0.50774841201655 0.915911629458156 Possible conserved membrane protein V - Conserved hypotheticals Rv2720 lexA 1409.5 824.8 501.9 1587 1668.4 942.2 1268.50830159984 0.480191879586661 0.199020843355488 2.41277180565931 0.0158317281115323 0.27541232677043 Repressor LexA I.J.1 - Repressors/activators Rv2721c - 102.4 64.2 41.1 119 86.3 70.6 264.078798266377 0.266204198223184 0.215199926169538 1.23700878044662 0.216083822892258 0.773070552038584 Possible conserved transmembrane alanine and glycine rich protein V - Conserved hypotheticals Rv2722 - 17.1 7 6.7 9.7 18.3 19.8 4.28879000742716 0.370914594066708 1.01458574363559 0.365582304298503 0.714676781510041 NA hypothetical protein VI - Unknowns Rv2723 - 29 16.8 13.2 19.6 29.4 20.1 39.9798960871343 0.0308201383717769 0.373388321850087 0.0825417844325377 0.934215892504084 0.998010361628995 Probable conserved integral membrane protein III.A.2 - Cations Rv2724c fadE20 86.3 87.3 42.2 67.7 78.9 66.4 134.179546882458 -0.202385385406893 0.273880006742333 -0.738956405814967 0.459933469371416 0.901158530199572 Probable acyl-CoA dehydrogenase FadE20 I.A.3 - Fatty acids Rv2725c hflX 115.2 80.7 66.7 113.6 105.2 61.2 214.949014993608 -0.10053764809532 0.225580930088063 -0.445683276756028 0.65582604623428 0.939577115195416 Probable GTP-binding protein HflX II.B.3 - Proteins, peptides and glycopeptides Rv2726c dapF 102 53.9 67.7 130.9 94.1 61.9 116.891576763064 0.157351308822335 0.28012092909914 0.561726356286093 0.574302474212714 0.925885039001838 Probable diaminopimelate epimerase DapF (DAP epimerase) I.D.2 - Aspartate family Rv2727c miaA 39.4 14.9 10.4 24 23.6 10.7 28.9739186081813 -0.227198339167392 0.445723327946235 -0.509729522603757 0.610240966933418 0.931582271037618 Probable tRNA delta(2)-isopentenylpyrophosphate transferase MiaA (IPP transferase) (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2728c - 31.5 9.9 8.8 28.5 10.6 24.2 19.1622914300061 0.191851316625359 0.551650998796674 0.347776614279405 0.72800795374276 NA Conserved alanine rich protein V - Conserved hypotheticals Rv2729c - 71.5 55.5 35.6 81.4 49.2 47.3 81.6300282806338 -0.0121276638180644 0.295659649005737 -0.0410190022847152 0.967280746977821 0.998153412295216 Probable conserved integral membrane alanine valine and leucine rich protein V - Conserved hypotheticals Rv2730 - 11.8 3.1 1.6 4.9 4 2.4 2.45954105385392 -0.928840256014053 1.37914810117288 -0.673488405794949 0.50063662243946 NA Hypothetical protein VI - Unknowns Rv2731 - 48.7 20.7 22.2 43.2 37 15.8 65.1123550905547 -0.075494002273464 0.332745069663434 -0.226882406852263 0.820515182647525 0.967203057682185 Conserved alanine and arginine rich protein VI - Unknowns Rv2732c - 75.4 15 17.8 91 56.7 43.1 44.5476772195305 0.730825226351998 0.432220911750332 1.69086040606511 0.0908634669068863 0.583128421031201 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2733c - 68.1 37.2 34 65.3 53.2 33.8 117.21512069491 -0.0370497421842431 0.257143214073726 -0.144082130721212 0.885435615099323 0.982420376752145 Conserved hypothetical alanine, arginine-rich protein V - Conserved hypotheticals Rv2734 - 8.3 5.2 0.9 8.5 6.3 3.2 6.10644112464614 0.146483129291184 0.883925026223128 0.165718952338167 0.868378130477813 NA hypothetical protein VI - Unknowns Rv2735c - 47.3 31.7 27.1 32.2 64.9 52.9 67.7530424326321 0.288588525842107 0.348578531973219 0.827901030532424 0.407726551288439 0.900776070977493 hypothetical protein VI - Unknowns Rv2736c recX 135.2 72.1 91 111.8 81.6 143.1 90.7559134721917 -0.0403523898167516 0.318556104755692 -0.126672787663884 0.899199384603446 0.98854987613174 Regulatory protein RecX II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2737c recA 256.3 145 107.9 225.6 202.2 164.7 685.766308748123 0.0736161228684075 0.172345966036606 0.42714154883539 0.669276231888045 0.940659582013381 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2737A - 4.9 2.5 3.8 0 3.3 13.3 0.923558546018437 -0.677915101446373 2.30501356673121 -0.294104603647839 0.768677973176441 NA Conserved hypothetical cysteine rich protein (fragment) ? Rv2738c - 44.5 7.6 16.8 65.6 31.7 20.1 8.75680543280834 0.606171110168528 0.772525028071058 0.784662099145313 0.432651710067123 NA hypothetical protein V - Conserved hypotheticals Rv2739c - 27.6 10.5 12.9 55.5 24.6 20.6 44.236947631721 0.849010823744445 0.406041481599211 2.09094602945636 0.0365329022780055 0.398982485820102 Possible alanine rich transferase IV.H - Miscellaneous transferases Rv2740 ephG 98.2 65 37.4 55.2 65 26.4 40.7949273623735 -0.587364888978966 0.375386237186804 -1.56469478844179 0.11765449105915 0.656813446599338 Epoxide hydrolase V - Conserved hypotheticals Rv2741 PE_PGRS47 55.6 30.3 37.1 56.1 30.3 51 111.362564128345 -0.0428659892570081 0.298159704819147 -0.14376855277278 0.885683236101407 0.982420376752145 PE-PGRS family protein PE_PGRS47 IV.C.1.b - PE_PGRS subfamily Rv2742c - 22.9 20.7 6.4 17.6 10.5 21.2 21.3731518071697 -0.178037984145284 0.516905096593075 -0.34443069979138 0.73052240454753 NA Conserved hypothetical arginine rich protein V - Conserved hypotheticals Rv2743c - 99.5 49.3 44.6 85.9 82.3 49.6 86.4508027324779 0.0158941299192294 0.279029721402221 0.0569621395145859 0.954575354438541 0.998153412295216 Possible conserved transmembrane alanine rich protein V - Conserved hypotheticals Rv2744c 35kd_ag 227.8 153.1 111.6 182.7 204.9 157.3 224.491785535325 -0.0280938778062751 0.211367714930832 -0.132914706559933 0.894260835948873 0.987435318257319 Conserved 35 kDa alanine rich protein V - Conserved hypotheticals Rv2745c clgR 147.2 73.3 107 149.4 98.2 59.5 57.295636145745 -0.295177992209571 0.358570853420093 -0.823206876393123 0.41039035914546 0.901158530199572 Transcriptional regulatory protein ClgR I.J.1 - Repressors/activators Rv2746c pgsA3 55.9 27.4 25.2 48.5 46.8 30.5 37.8668217703576 0.0614225139512783 0.371031852178569 0.165545123931077 0.868514935991155 0.977876220223739 Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) (phosphatidylglycerophosphate synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2747 argA 27.9 23 10.2 30.4 18.9 5.4 15.1033852763657 -0.209884734540743 0.601872388671351 -0.348719659667507 0.727299783411652 NA Probable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase) V - Conserved hypotheticals Rv2748c ftsK 213.6 109.6 82.5 195.6 154.5 108.2 592.869292981878 0.0390438616851767 0.196770582114345 0.198423266657249 0.842713915172537 0.974476040705366 Possible cell division transmembrane protein FtsK III.C - Cell division Rv2749 - 98.8 26.3 28.3 64.3 69.4 58 26.8246250957631 0.147618327031647 0.460779613977589 0.320366445375829 0.748690558878785 0.957707961696119 hypothetical protein V - Conserved hypotheticals Rv2750 - 88.2 53.2 36.6 62 58.3 40.8 72.5925064823231 -0.295970470736726 0.290590719193108 -1.01851315678132 0.308434151538183 0.844880251285152 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2751 - 65.1 25.2 25.2 55.2 28.6 49.6 57.5374332866965 0.091631299273677 0.353798761220763 0.258992708051063 0.795640866724641 0.965360560531176 hypothetical protein V - Conserved hypotheticals Rv2752c - 169.4 102.2 72.2 158.8 127.5 101.7 321.437388783579 0.0248913895957659 0.197502408784379 0.126030815264338 0.899707531998376 0.98854987613174 hypothetical protein V - Conserved hypotheticals Rv2753c dapA 327.2 209.8 122.6 216.7 178.7 185.6 296.101332364006 -0.320482329630591 0.213253138085419 -1.50282585526231 0.132883956746594 0.680441181456551 Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase) I.D.2 - Aspartate family Rv2754c thyX 9.5 10.3 5.2 8.5 9.2 11.3 10.8486965321449 0.0413117284081373 0.658698597275978 0.0627171950554932 0.949991704674892 NA Probable thymidylate synthase ThyX (ts) (TSase) V - Conserved hypotheticals Rv2755c hsdS.1 26.8 33.9 19.6 28.3 47.9 41 14.2272128473663 0.261529195989787 0.601656999133005 0.434681548401587 0.663793593397231 NA Possible type I restriction/modification system specificity determinant (fragment) HsdS.1 (S protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2756c hsdM 28.6 31.4 10 35.2 36 33.6 74.8424120266965 0.439941432054085 0.335216936791957 1.31240812670251 0.189382466334656 0.739746500217031 Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2757c vapC21 37 26.8 20.2 27.7 46.9 37.9 21.3764959654708 0.190128194872746 0.490461879075945 0.387651320080078 0.69827408496401 NA Possible toxin VapC21 V - Conserved hypotheticals Rv2758c vapB21 32.2 31.6 7.7 41.1 71.9 27.9 14.1498307837676 0.86144057571014 0.609389217440745 1.41361309169193 0.15747553525015 NA Possible antitoxin VapB21 V - Conserved hypotheticals Rv2759c vapC42 42.1 17.9 29.9 40.4 53.4 27.3 21.6454198368627 0.231599750419222 0.489090746041626 0.473531246079865 0.635834214196804 NA Possible toxin VapC42 Contains PIN domain V - Conserved hypotheticals Rv2760c vapB42 52.9 31.7 30.9 42 60.4 62.8 20.1851379631523 0.265111543358726 0.502572121711802 0.527509449699944 0.597839855971309 NA Possible antitoxin VapB42 V - Conserved hypotheticals Rv2761c hsdS 65.9 41.4 29.3 62 53.4 59 89.599451438677 0.197407185427112 0.273420853162771 0.721990232799079 0.470300482568794 0.902597484602108 Possible type I restriction/modification system specificity determinant HsdS (S protein) VI - Unknowns Rv2762c - 54.5 49.1 22.1 77 36.5 25.2 28.2073925082933 0.0632525935056153 0.465304927948099 0.135937940276168 0.891870341849581 0.985189043752372 hypothetical protein VI - Unknowns Rv2763c dfrA 82.3 55.2 46.6 77.8 74 70 51.461289505536 0.0840762989023651 0.327104228895197 0.257032136778955 0.797153964700806 0.965592404376002 Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) I.G.2 - Folic acid Rv2764c thyA 146.7 65.6 57.4 87.5 130.7 91.3 119.297662077126 0.0428411211416648 0.275642335610159 0.155422863642597 0.876487960596474 0.980703859230131 Probable thymidylate synthase ThyA (ts) (TSASE) I.F.3 - 2'-deoxyribonucleotide metabolism Rv2765 - 3.6 0 0 0.7 5 0 1.39257058286233 0.352093120948113 1.93742922255457 0.181732120507538 0.855792957176503 NA Probable alanine rich hydrolase VI - Unknowns Rv2766c - 21.5 9.7 11 14.7 10.9 3.6 13.9159153986763 -0.706155268755351 0.607664984751074 -1.16207990665222 0.24520300847821 NA Probable short-chain type dehydrogenase/reductase I.H.1 - Synthesis of fatty and mycolic acids Rv2767c - 20.3 0 14.4 6.7 4.9 0 4.00302327265814 -1.73014409186199 1.2148130221706 -1.42420607969003 0.154386825486734 NA Possible membrane protein VI - Unknowns Rv2768c PPE43 15.3 2.9 17.2 6.5 8 9.6 19.5182467363433 -0.964202925635447 0.609333691812021 -1.58238899078127 0.113560796418819 NA PPE family protein PPE43 IV.C.2 - PPE family Rv2769c PE27 16.3 9.8 7.3 8.3 7.8 6.7 11.6805161963749 -0.775334196136349 0.627047479143205 -1.23648403338733 0.216278697082204 NA PE family protein PE27 IV.C.1.a - PE subfamily Rv2770c PPE44 34.4 18.4 17.8 19.8 25.2 25 42.606493828617 -0.241263367597092 0.365871591650123 -0.659420881815301 0.509625536481103 0.915911629458156 PPE family protein PPE44 IV.C.2 - PPE family Rv2771c - 88.2 52.5 50.6 82.5 67.6 56.5 47.7794622772348 -0.0657570202407535 0.337302985395395 -0.194949416660726 0.845432547392394 0.975474031954732 hypothetical protein VI - Unknowns Rv2772c - 110.7 103 71 103.8 79.7 102 73.8271963782048 -0.195454769753741 0.311573161578709 -0.62731580847141 0.530452242970233 0.922751607774049 Probable conserved transmembrane protein VI - Unknowns Rv2773c dapB 148.4 87.7 80.2 126.2 106.5 117.6 131.533666891982 -0.0374905835555734 0.245307825109072 -0.152830769009932 0.878531732603631 0.980703859230131 Dihydrodipicolinate reductase DapB (DHPR) I.D.2 - Aspartate family Rv2774c - 12.8 21.3 5.1 25.2 9.1 1.6 7.50616235250698 -0.190878331559897 0.877769662951548 -0.217458337439071 0.827851172009214 NA Hypothetical protein VI - Unknowns Rv2775 - 47 19.7 21.7 30.2 57.7 26.4 23.9167398976348 0.200417474422473 0.47839036690368 0.418941283704456 0.675259044619366 NA GCN5-related N-acetyltransferase VI - Unknowns Rv2776c - 48.2 23.2 12.7 46.5 47.9 32.7 49.1333050718419 0.472455640049362 0.356199730801102 1.32637843096287 0.184714379520656 0.739746500217031 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2777c - 99.9 60.8 44.6 99.9 117.6 92.7 144.520652804889 0.432216326997156 0.23762596667281 1.81889350330252 0.0689276792023207 0.520912460856883 hypothetical protein VI - Unknowns Rv2778c - 200.6 150.6 93.8 185.6 248.6 174.6 130.913428875878 0.282127253066425 0.256193300402243 1.10122806733612 0.270797408987994 0.812783093966197 hypothetical protein V - Conserved hypotheticals Rv2779c - 106.6 98.2 48.5 84.6 98.5 89.8 75.9747801944896 -0.0661802875207673 0.309466609079273 -0.213852756902166 0.830661882423094 0.968638603196576 Possible transcriptional regulatory protein (probably Lrp/AsnC-family) I.J.1 - Repressors/activators Rv2780 ald 127 105.6 80.3 61.7 127.9 101.7 184.863122193126 -0.319772364116805 0.296256012610562 -1.07937847842824 0.280419040974803 0.822522870982296 Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) I.A.2 - Amino acids and amines Rv2781c - 140.6 85 77.2 143.6 134.5 83.6 181.259822630007 0.0694039644557022 0.226309073632848 0.306677780707545 0.759088643763947 0.959593750764785 Possible alanine rich oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2782c pepR 254.5 120.3 108.5 288.3 197.7 147.8 379.986113709344 0.24096674824059 0.216625257760018 1.11236681600415 0.265980466335099 0.80816433845196 Probable zinc protease PepR II.B.3 - Proteins, peptides and glycopeptides Rv2783c gpsI 389.1 213.5 215.9 293.4 323.7 271.9 1033.06172783466 -0.0559430691155911 0.18135402647841 -0.308474370279564 0.757721399551851 0.959593750764785 Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (pnpase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2784c lppU 205.6 102.1 124.4 174.3 132.4 134.8 119.925486300224 -0.162554790245066 0.261555061956272 -0.621493573969686 0.534274921258222 0.923128239106977 Probable lipoprotein LppU II.C.1 - Lipoproteins(lppA-lpr0) Rv2785c rpsO 1168.9 636.1 478.8 496.9 866.9 595.6 303.530822026814 -0.363106536983551 0.245577785467148 -1.47858054951035 0.1392524543322 0.682181933169668 30S ribosomal protein S15 RpsO II.A.1 - Ribosomal protein synthesis and modification Rv2786c ribF 64.9 37.2 25.7 56.6 61.3 37.1 72.4304495017777 0.134040157769275 0.294481172708077 0.455173947239575 0.648984101902857 0.939577115195416 Probable bifunctional FAD synthetase/riboflavin biosynthesis protein RibF: riboflavin kinase (flavokinase) + FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)(FAD diphosphorylase) (flavin adenine dinucleotide synthetase) I.G.9 - Riboflavin Rv2787 - 15.3 9 6.7 12.1 20.7 1.6 29.0855412887683 -0.0131075547400441 0.505464285532275 -0.0259317129126964 0.979311805300067 0.998567088804884 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2788 sirR 66.5 37.8 36.8 69.3 44 24.6 50.3893937883978 -0.169175460419324 0.356952552084298 -0.473943832118539 0.635539961245354 0.934597866696866 Probable transcriptional repressor SirR I.J.1 - Repressors/activators Rv2789c fadE21 140 99.5 65.6 141.4 107.5 86.1 208.133908959804 -0.0235619792645274 0.220940065682954 -0.106644212274013 0.915071242241512 0.9932884147079 Probable acyl-CoA dehydrogenase FadE21 I.A.3 - Fatty acids Rv2790c ltp1 227 166.1 123.4 183.2 185.2 159.5 338.816923571615 -0.153137093497006 0.196830180457619 -0.778016324229195 0.436559389687965 0.901158530199572 Probable lipid-transfer protein Ltp1 III.A.5 - Fatty acid transport Rv2791c - 1191.2 606.3 365.7 725.8 928.3 723.2 1626.91578152365 0.0547583302083482 0.209372602167332 0.261535318573272 0.793679716724767 0.965360560531176 Probable transposase IV.B.1.c - Others Rv2792c - 277.4 186.4 161.4 323.1 244.6 155 207.651955776632 0.0223625726788064 0.233973149012171 0.0955775172203333 0.923856122096607 0.995376050215915 Possible resolvase IV.B.1.c - Others Rv2793c truB 106.3 61 72.4 111.3 62.6 63.3 114.780011445857 -0.213342587768815 0.285584693811053 -0.747037892408776 0.455040688209668 0.901158530199572 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2794c pptT 93.3 69.8 35.7 128.7 83.6 73.7 85.8168680505733 0.387872715200874 0.294621323803196 1.31651270245452 0.188002017821368 0.739746500217031 Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase) V - Conserved hypotheticals Rv2795c - 134.9 79.7 66.8 107.9 107.6 81.5 149.111000317606 -0.101499497669576 0.228015291087682 -0.44514338132939 0.656216140176345 0.939577115195416 hypothetical protein VI - Unknowns Rv2796c lppV 40.8 35.1 13.9 25.1 33.5 20.3 24.6877117133738 -0.368155623027456 0.465125891234895 -0.791518231870547 0.428641641297016 NA Probable conserved lipoprotein LppV II.C.1 - Lipoproteins(lppA-lpr0) Rv2797c - 19.2 11.7 9.6 19.6 17.5 31 48.7062204954727 0.537037111366499 0.372780728456369 1.44062466316403 0.149690748882876 0.695223866622759 hypothetical protein V - Conserved hypotheticals Rv2798c - 104.4 122.1 49 111.6 126.9 38.7 47.2011352912997 -0.140672287849087 0.401552544939409 -0.350320996895471 0.726097809212098 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv2799 - 67.5 50.3 27 66.3 35.2 24.7 44.3286090698682 -0.283459392414405 0.383062429089046 -0.739982234980587 0.459310773833466 0.901158530199572 Probable membrane protein VI - Unknowns Rv2800 - 38.7 25 19.1 39.4 30 27.2 77.5034551940178 0.0700716242344922 0.282645268349723 0.247913664515307 0.80420120713397 0.965592404376002 Possible hydrolase V - Conserved hypotheticals Rv2801c mazF9 18.2 14.3 6.2 17.8 19.3 19.6 8.42042330934731 0.494291020899517 0.725180540402698 0.681610982866464 0.495484968361167 NA Toxin MazF9 V - Conserved hypotheticals Rv2801A mazE9 22.9 16.6 7.6 21.3 25.1 12.2 5.44310681766067 0.198200466843212 0.891701967940679 0.222272097594381 0.824102071723556 NA Possible antitoxin MazE9 ? Rv2802c - 17.6 5.7 7.7 20.5 15.4 4.5 17.9094051759588 0.246113754080338 0.563327086778349 0.436893165368375 0.662188828797125 NA Hypothetical arginine and alanine rich protein VI - Unknowns Rv2803 - 14.2 7.4 13.6 3.7 4.5 0 5.29177149229425 -2.45181761669173 1.06565772106346 -2.30075526900416 0.0214054681235766 NA hypothetical protein ? Rv2804c - 0.5 0 0 0 0 0 0.0448007840762574 -0.318231606298853 4.0267484609073 -0.0790294227186839 0.937009220301446 NA Hypothetical protein VI - Unknowns Rv2805 - 15 13.2 0 18.9 12 20.8 8.15158661704884 0.820956020558791 0.81243276537491 1.01049102836214 0.312260095611453 NA hypothetical protein V - Conserved hypotheticals Rv2806 - 9.5 10.9 2.9 12.5 8.1 3.2 1.7946377012324 -0.0258262674510115 1.59014232146024 -0.0162414817230291 0.987041742191717 NA Possible membrane protein VI - Unknowns Rv2807 - 1.7 1.7 0.7 0.1 1.7 0.1 1.24445041707145 -1.91219124382976 1.91924003875324 -0.996327298940648 0.319091144006632 NA hypothetical protein V - Conserved hypotheticals Rv2808 - 41.8 60.1 31.5 23.5 24.9 48.9 16.4815022314011 -0.817047534922393 0.604495612824595 -1.3516186347567 0.176497345903291 NA Hypothetical protein VI - Unknowns Rv2809 - 204.1 148.7 142.4 190.6 206.7 219 94.2519434507256 0.101621269229374 0.288148380064908 0.352669930701962 0.724335904509666 0.949890877982223 Hypothetical protein VI - Unknowns Rv2810c - 0 0 0 0 0 0 0 NA NA NA NA NA Probable transposase IV.B.1.c - Others Rv2811 - 11.9 7 3.5 10.7 3.3 1.2 5.21525368941543 -0.719518514192505 1.00210872113913 -0.718004443045466 0.472754547289377 NA hypothetical protein V - Conserved hypotheticals Rv2812 - 4 3.7 1.4 4.7 2.6 7.8 8.88200820528212 0.506579114560669 0.743402425050219 0.681433228478435 0.495597403353791 NA Probable transposase IV.B.1.c - Others Rv2813 - 1.9 2.1 1.3 1.8 0 0 1.18471976915268 -0.931594514194307 1.9008107914083 -0.490103759093293 0.624060478199836 NA hypothetical protein III.D - Protein and peptide secretion Rv2814c - 4.5 3.2 4.1 3.2 7 0 5.69708063376316 -0.435515107469819 0.920816938350222 -0.472966003698963 0.636237433720902 NA Probable transposase IV.B.1.a - IS6110 Rv2815c - 12.5 4.1 6.8 15.4 8.5 0 3.55273124925961 0.0030818373607407 1.1295714229844 0.00272832447601966 0.997823114724424 NA Probable transposase IV.B.1.a - IS6110 Rv2816c - 22.1 17.4 5 6.7 31.9 59.9 12.5796893312725 1.08221874437809 0.792306284076697 1.36590958083746 0.171967345205012 NA hypothetical protein V - Conserved hypotheticals Rv2817c - 13.6 19.4 9 8.1 14.6 14.7 22.0196658572735 -0.483926838093405 0.533008627822615 -0.907915581161015 0.363922824852931 NA hypothetical protein V - Conserved hypotheticals Rv2818c - 52.8 42.3 40.9 40.4 81.6 66.5 101.36829483478 0.2282744972688 0.332223295074568 0.687111652473267 0.492012371802088 0.912135536464192 Hypothetical protein VI - Unknowns Rv2819c - 43.9 15.3 24.4 36.3 43.8 26.6 55.4987877581429 0.154428400996637 0.34425297502203 0.448589880702569 0.65372753495921 0.939577115195416 Hypothetical protein VI - Unknowns Rv2820c - 48.3 19.9 24.3 42.5 47.4 26 48.4993068024184 0.129027197285785 0.348443834329151 0.370295538545538 0.711162297664403 0.949890877982223 Hypothetical protein VI - Unknowns Rv2821c - 46.1 23.5 21.3 37.3 49.1 35.4 39.0766380217937 0.216455366781595 0.370144400292858 0.584786279652848 0.558691431024302 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv2822c - 36.6 51.2 29.6 27.1 51 57.3 25.9852389720228 -0.0662673461510873 0.508938781204846 -0.130206910139974 0.896402727624076 NA Hypothetical protein VI - Unknowns Rv2823c - 23.7 19.8 17 20.3 29.3 22.9 87.661177345832 0.0290268212983493 0.303916920518656 0.0955090662567027 0.923910489350188 0.995376050215915 hypothetical protein V - Conserved hypotheticals Rv2824c - 34.9 23.4 14.7 27.3 26.1 21.3 36.1256582037315 -0.136839885565413 0.376448993655039 -0.363501796715671 0.716230070997052 0.949890877982223 Hypothetical protein VI - Unknowns Rv2825c - 171.2 91.8 78.4 131.5 110.5 79.6 112.720422402131 -0.241412792337638 0.253023405155638 -0.95411249480712 0.340026702040842 0.855368447926409 hypothetical protein V - Conserved hypotheticals Rv2826c - 100.2 45.4 50.5 72.5 45.7 52.3 85.7002516723975 -0.358408577842492 0.292364999621504 -1.22589427019817 0.220238465295157 0.773070552038584 Hypothetical protein VI - Unknowns Rv2827c - 129.2 62 65.3 85.7 67.5 42.3 106.255981819427 -0.541574897243774 0.272292688582138 -1.98894395609307 0.0467073892798347 0.436461617391969 Hypothetical protein VI - Unknowns Rv2828c - 68.4 24.6 42.4 66.4 49.1 28.1 40.111983967523 -0.0908667471671535 0.394107774768412 -0.230563193584672 0.817654164468806 0.967203057682185 hypothetical protein V - Conserved hypotheticals Rv2828A - 86.1 26.1 44.4 58.6 45.4 19.4 19.188826791622 -0.443651437047995 0.530522677895106 -0.836253482712973 0.403012316345601 NA hypothetical protein ? Rv2829c vapC22 130.8 44.9 68.6 75.6 84.1 26.5 43.8448956761136 -0.558507363957191 0.391560970437093 -1.42636117009757 0.153764116000766 0.703772013967798 Possible toxin VapC22 V - Conserved hypotheticals Rv2830c vapB22 322 137 126.6 246.8 172.5 147.7 63.7544387139742 -0.185397221952083 0.319325995888989 -0.580589192044781 0.561517358220895 0.92521033104044 Possible antitoxin VapB22 IV.B.3 - Phage-related functions Rv2831 echA16 72.2 20.7 29.6 49.5 39.4 36.1 47.2730565636981 -0.150433007901168 0.36699056436111 -0.409909742946811 0.681872158033651 0.942913432418385 Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2832c ugpC 12.2 10.8 3.3 12.9 17.9 10.5 18.2766427683176 0.512802023455202 0.529758473852164 0.967992111058342 0.333048309628362 NA Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC III.A.3 - Carbohydrates, organic acids and alcohols Rv2833c ugpB 11.2 7.9 7 10.6 14.6 6.5 19.9775348127054 0.0876225720087427 0.493967025344664 0.177385468083835 0.859205621102493 NA Probable Sn-glycerol-3-phosphate-binding lipoprotein UgpB III.A.3 - Carbohydrates, organic acids and alcohols Rv2834c ugpE 11.7 5.1 8.9 12.9 12.5 10 12.904285642424 0.188626650277628 0.597618630997193 0.31563047149799 0.752283006214749 NA Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE III.A.3 - Carbohydrates, organic acids and alcohols Rv2835c ugpA 10.9 12.7 4.1 9.5 9.3 9.6 13.2543941939754 -0.101760039817148 0.612132264977355 -0.166238647493793 0.86796914626497 NA Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA III.A.3 - Carbohydrates, organic acids and alcohols Rv2836c dinF 45.8 35 26.9 82.7 42.8 26.2 89.0640359603889 0.322754646973009 0.32794660893355 0.984168270629707 0.325032783800435 0.853347384539607 Possible DNA-damage-inducible protein F DinF II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2837c - 163.2 130 88.6 236.1 144.8 130.8 238.822112080635 0.23662259244165 0.235674302046213 1.00402373269891 0.315367174428323 0.847340730510678 hypothetical protein V - Conserved hypotheticals Rv2838c rbfA 454 292.5 271.2 482.2 366.6 364.6 329.734947282214 0.0614388888327723 0.202966766814532 0.302704180576096 0.76211531154334 0.959593750764785 Probable ribosome-binding factor a RbfA (P15B protein) II.A.2 - Ribosome modification and maturation Rv2839c infB 334.7 185.6 168.4 288 259.5 206.6 1032.86917831917 -0.038218488323343 0.165297242101113 -0.231210683478704 0.817151130637243 0.967203057682185 Probable translation initiation factor if-2 InfB II.A.6 - Protein translation and modification Rv2840c - 1647.4 1195.8 1492.5 972.7 1191.6 1138.4 647.024368312404 -0.643658846590058 0.24932207064432 -2.58163605382652 0.00983332232931328 0.202977384797616 hypothetical protein V - Conserved hypotheticals Rv2841c nusA 135.9 70.9 59.1 120.7 94.5 87.6 155.110662547353 0.0393343621994055 0.231163401804246 0.170158259881963 0.864885676735014 0.97763538285617 Probable N utilization substance protein A NusA II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2842c - 187.2 135.6 111.1 243.4 133.5 130.6 138.057567994603 0.0444057521745038 0.267639465566621 0.165916308644886 0.868222812938645 0.977876220223739 hypothetical protein V - Conserved hypotheticals Rv2843 - 45.7 17.4 12.7 30.9 17.8 5.4 16.8519070297288 -0.580075905749922 0.596839978799602 -0.971911946844786 0.331094355843205 NA Probable conserved transmembrane alanine rich protein VI - Unknowns Rv2844 - 55.5 24.2 24 62.9 61.1 50.2 34.821051377805 0.574411979985975 0.385613920577387 1.48960384813364 0.13632842960643 0.682181933169668 Conserved alanine rich protein VI - Unknowns Rv2845c proS 92.4 55.8 40.7 45.2 44 39.1 148.143979872803 -0.721055331278203 0.233154190131248 -3.09261150688437 0.00198403680371631 0.0751759698504016 Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2846c efpA 1072.8 715.6 552 517.4 511.9 404.1 1631.67338037251 -0.886966838942079 0.160058630142819 -5.54151212059385 2.99870814958185e-08 6.38032826287954e-06 Possible integral membrane efflux protein EfpA III.A.6 - Efflux proteins Rv2847c cysG 77.5 29.7 33.6 61 52.9 62.2 100.970413648204 0.158799712396751 0.281826885459276 0.563465448436423 0.573117981359596 0.925885039001838 Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase I.D.3 - Serine family Rv2848c cobB 79.9 38.8 47.4 61 46.5 46.9 117.5942388982 -0.302285960089508 0.26318821533859 -1.14855431387997 0.250739804721445 0.796128980119145 Probable cobyrinic acid A,C-diamide synthase CobB I.G.13 - Cobalamin Rv2849c cobO 161.4 87.5 93 146.5 120.1 110.7 119.195697648387 -0.0453704548289978 0.251492623869542 -0.180404713788079 0.856834853972564 0.975712312098852 Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity) I.G.13 - Cobalamin Rv2850c - 135.3 52.1 84.2 126.2 79.3 51.1 264.068454039755 -0.288252232378446 0.281442371139338 -1.02419629003103 0.305742570738073 0.844880251285152 Possible magnesium chelatase IV.K - Chelatases Rv2851c - 257 165.5 145 241.8 213.8 148.2 146.762450597747 -0.0899001245279279 0.235118633517784 -0.382360696737922 0.702193839030456 0.947279830180307 GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv2852c mqo 140.9 103.1 60 112.9 101.2 81.2 235.090442972076 -0.19787479377501 0.214724664597669 -0.92152801423986 0.356774822152027 0.876411330437395 Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]) V - Conserved hypotheticals Rv2853 PE_PGRS48 17.3 4.8 12.8 19.2 12.3 4.2 33.58245251299 -0.168866187404587 0.484306779176624 -0.348676076126125 0.727332506900506 0.949890877982223 PE-PGRS family protein PE_PGRS48 IV.C.1.b - PE_PGRS subfamily Rv2854 - 16.8 27.6 9.1 11.8 20.6 5.9 25.460992667217 -0.670391523746681 0.524986248704053 -1.27696968330421 0.201612950668123 NA hypothetical protein VI - Unknowns Rv2855 mtr 108.9 63.2 55 66.5 77 58 158.011091879088 -0.357321797189917 0.23080958608846 -1.54812372937132 0.121592509942881 0.665646250765128 NADPH-dependent mycothiol reductase Mtr I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv2856 nicT 95.2 73.5 63.8 79.2 97 72.6 145.483202657084 -0.122537608183505 0.25111308781891 -0.487977784223947 0.625565576971592 0.933790818080639 Possible nickel-transport integral membrane protein NicT III.A.2 - Cations Rv2857c - 74.1 61.7 40.3 70.9 57.1 81.7 80.9548303495081 0.0732215571199076 0.303080141808602 0.241591404448226 0.809096783083692 0.965980858268586 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2858c aldC 82.8 44.4 37.1 88.3 75.1 46.5 132.23758210502 0.204824827006126 0.248142376785767 0.825432679654556 0.4091259879754 0.901158530199572 Probable aldehyde dehydrogenase AldC I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2859c - 51.4 41.9 25.6 49.7 48.4 28.8 59.646705670506 -0.0617089103123314 0.319092742170228 -0.193388636459212 0.846654614248507 0.975474031954732 Possible amidotransferase V - Conserved hypotheticals Rv2860c glnA4 48.6 34.7 26.4 49 45.3 47 92.2998076828754 0.184552025379497 0.271369001727813 0.680077769400522 0.496455219727933 0.913636152872564 Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) I.D.1 - Glutamate family Rv2861c mapB 393.7 287.6 213.9 230 342 319.7 416.371042884081 -0.182116491138598 0.235833252122841 -0.772225670041375 0.439980780301373 0.901158530199572 Methionine aminopeptidase MapB (map) (peptidase M) II.B.3 - Proteins, peptides and glycopeptides Rv2862c - 26.9 10.1 12.3 27.2 32.6 17.9 18.7698897284222 0.494315219458974 0.509062678819823 0.971030169811234 0.331533255082977 NA hypothetical protein V - Conserved hypotheticals Rv2862A vapB23 0.8 0 0 0 0 0 0.0224003920381287 -0.0353864558230091 4.03001480255116 -0.00878072601634317 0.992994084306394 NA Possible antitoxin VapB23 ? Rv2863 vapC23 0.1 0 0 0.3 0.2 3.7 0 NA NA NA NA NA Possible toxin VapC23 V - Conserved hypotheticals Rv2864c - 17.2 10.3 3.7 19.9 13.6 19.3 38.7517302003472 0.64127245447846 0.406576885878791 1.57724769102993 0.114738543331349 0.651222777732727 Possible penicillin-binding lipoprotein II.C.3 - Murein sacculus and peptidoglycan Rv2865 relF 94.4 69.3 52.5 78.8 125.9 97.2 38.7978506911721 0.284496214019457 0.388350425200224 0.732576033289464 0.463817053181451 0.901158530199572 Antitoxin RelF V - Conserved hypotheticals Rv2866 relG 25.9 23.4 26.7 38 45.9 34.1 13.6393824362721 0.344083438048411 0.600058863098516 0.573416141662623 0.566362963564496 NA Toxin RelG V - Conserved hypotheticals Rv2867c - 325.4 165.6 107.5 292.8 180.1 126.4 261.834222773901 -0.114511411128701 0.25363128708458 -0.451487718431653 0.651638074757352 0.939577115195416 GCN5-related N-acetyltransferase VI - Unknowns Rv2868c gcpE 357.8 227.2 229 268.4 266.6 191.7 486.021389912945 -0.37233989833886 0.1947931820151 -1.91146268307274 0.0559451479706168 0.489697086350399 Probable GcpE protein V - Conserved hypotheticals Rv2869c rip 142.8 90.4 67.7 111 83.8 78.7 185.431509025763 -0.297242919747128 0.220923606812071 -1.34545567147099 0.178478127338055 0.734764437650925 Membrane bound metalloprotease II.C.5 - Other membrane proteins Rv2870c dxr 82.3 42 35.6 56.9 37.2 42.4 96.954048015819 -0.368124390889874 0.274848891514256 -1.33937011301637 0.180450213989734 0.735038480974451 Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase) V - Conserved hypotheticals Rv2871 vapB43 45.9 25.9 8.8 40.4 44.5 20.2 11.6008471450725 0.313725196567883 0.646393506231798 0.48534707348279 0.627430169080711 NA Possible antitoxin VapB43 V - Conserved hypotheticals Rv2872 vapC43 17.4 4.8 2.4 11.9 13.7 23.7 7.92150627422667 0.814437253362513 0.828076673517381 0.983528795592161 0.325347250210026 NA Possible toxin VapC43 Contains PIN domain V - Conserved hypotheticals Rv2873 mpt83 17 3.9 7.2 7.1 20.3 10.1 10.4624212412383 0.13565341905599 0.713650932246638 0.190083713096178 0.849243532470275 NA Cell surface lipoprotein Mpt83 (lipoprotein P23) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2874 dipZ 6.9 8.2 2.9 3 6.6 9.5 20.6482414831412 -0.179008164471282 0.574155789160525 -0.3117762946064 0.755210540858057 NA Possible integral membrane C-type cytochrome biogenesis protein DipZ II.C.5 - Other membrane proteins Rv2875 mpt70 23.3 20.2 25 20.7 18.1 20.1 20.1905044374408 -0.52250423585524 0.518540364793115 -1.00764428640711 0.313625260271733 NA Major secreted immunogenic protein Mpt70 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2876 - 100.6 70.9 46 94.5 103.9 37.8 36.882626178151 -0.00950737948672088 0.388151562215122 -0.0244939874322899 0.980458579611659 0.998567088804884 Possible conserved transmembrane protein VI - Unknowns Rv2877c - 39.8 13.7 15.4 41.5 16 1.8 26.8463186802631 -0.424732248156088 1.15921189705311 -0.366397419864151 0.714068544737101 0.949890877982223 Probable conserved integral membrane protein III.A.2 - Cations Rv2878c mpt53 218.4 189.8 132.2 139.6 205.1 155.2 147.777822558549 -0.328570473692473 0.26668004447574 -1.23207746698259 0.217920147708164 0.773070552038584 Soluble secreted antigen Mpt53 precursor II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2879c - 565.9 282.5 291.2 395.2 472.7 258.8 341.215395207355 -0.194411146877373 0.216010410094912 -0.900008230121649 0.368115870881788 0.883373818299354 hypothetical protein V - Conserved hypotheticals Rv2880c - 197.8 111.7 104.7 147.1 202.3 91.2 186.64669016545 -0.0958865192137325 0.249226602624686 -0.384736293011743 0.700432803172669 0.947279830180307 hypothetical protein V - Conserved hypotheticals Rv2881c cdsA 151 85.5 62 193.9 122.9 96.2 169.20102279034 0.332004085632987 0.247875266717969 1.33939981196566 0.180440550602073 0.735038480974451 Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2882c frr 300.5 251.9 198 175.6 283.7 304 232.633852986956 -0.181904226490498 0.281850747238399 -0.645392032034021 0.518673165647098 0.915911629458156 Ribosome recycling factor Frr (ribosome releasing factor) (RRF) II.A.6 - Protein translation and modification Rv2883c pyrH 290.1 149.1 118.1 269.8 187.7 205.5 251.081257215844 0.116152719042054 0.218047985404764 0.532693383185537 0.594245847251081 0.929159985017801 Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv2884 - 48.6 11.3 38.4 27.2 14.4 12.6 31.1596306415024 -1.09802975770613 0.503470825572116 -2.1809203273266 0.0291893099330156 0.361311748957762 Probable transcriptional regulatory protein I.J.2 - Two component systems Rv2885c - 60.4 40.9 27.3 76.6 46.4 36.3 103.190275960422 0.167559897128067 0.282513005173536 0.59310507502174 0.553110834271657 0.92521033104044 Probable transposase IV.B.1.c - Others Rv2886c - 20.3 11.4 17.8 36.4 28.1 15.3 29.9442540502779 0.516188364737969 0.438954372494605 1.17594993257372 0.239614883828083 0.78958848015113 Probable resolvase IV.B.1.c - Others Rv2887 - 44.3 26.6 12.4 48.7 36.1 47.2 22.6490504317644 0.508972346682981 0.473691167859281 1.07448139466721 0.282606979176634 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv2888c amiC 166.5 85.2 93 176.8 136.4 109.2 288.104912465803 0.112571144937434 0.212228742784646 0.530423652613646 0.59581823040049 0.929194918847511 Probable amidase AmiC (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2889c tsf 210.3 109.9 101.9 203.7 138.4 156.7 198.150456797932 0.0817740603280713 0.228411256900658 0.358012391498012 0.720334040288092 0.949890877982223 Probable elongation factor Tsf (EF-ts) II.A.6 - Protein translation and modification Rv2890c rpsB 276.9 154.6 224.6 159.9 220.1 161.7 286.671474676657 -0.520540914858563 0.261157910895838 -1.99320370220828 0.046239145886408 0.433550771260355 30S ribosomal protein S2 RpsB II.A.1 - Ribosomal protein synthesis and modification Rv2891 - 1.1 2.3 0.3 1.5 0.9 5.2 1.72693459096833 1.1353480166539 1.7113689536229 0.663415106514825 0.507064733472354 NA hypothetical protein VI - Unknowns Rv2892c PPE45 17 4.8 8.1 9.9 9 9.2 18.0326468510876 -0.292647993907917 0.530284488762242 -0.551869798400096 0.581037561794523 NA PPE family protein PPE45 IV.C.2 - PPE family Rv2893 - 3.2 1.8 1 4.1 1.9 0 2.28666338311063 0.0458726952813591 1.38393370324659 0.0331465988390524 0.973557682647689 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2894c xerC 79.6 27 29.9 80.9 63.2 37.9 72.3201772657109 0.295248231783494 0.323514353945852 0.912627919541743 0.361438265265766 0.882466185309938 Probable integrase/recombinase XerC IV.B.3 - Phage-related functions Rv2895c viuB 78.4 62.2 36.9 60.1 57.5 42 76.5059462114499 -0.303481121574056 0.290206278545322 -1.04574278370294 0.295679804013412 0.837161771605085 Possible mycobactin utilization protein ViuB I.G.14 - Iron utilisation Rv2896c - 35.5 24.6 10.1 24 16.6 22.9 40.2401113329183 -0.284582017851953 0.388366838970703 -0.73276600702106 0.463701157435799 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2897c - 6.7 4.3 3.6 9.9 5.2 2.3 12.3014870823676 0.20083362629513 0.629037756785088 0.319271179080821 0.749520885689074 NA hypothetical protein V - Conserved hypotheticals Rv2898c - 28.3 23.1 17.6 68.3 44.3 42 21.8619747313018 1.05133279315095 0.477873820107577 2.20002173986907 0.0278053526378748 NA hypothetical protein V - Conserved hypotheticals Rv2899c fdhD 57.2 31.9 32.1 56.7 52.3 41.2 59.3918103955271 0.135142758072222 0.309798312724517 0.436228192735173 0.662671174897008 0.939577115195416 Possible FdhD protein homolog I.B.6.b - anaerobic Rv2900c fdhF 149.9 91.1 73.4 121.1 124.6 84.7 399.4527900707 -0.099070538741379 0.186617589486974 -0.530874603051789 0.595505678094905 0.929194918847511 Possible formate dehydrogenase H FdhF (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (formate dehydrogenase-H alpha subunit) (FDH-H) I.B.6.b - anaerobic Rv2901c - 1023 812.2 542.8 782.8 842.3 930 409.077243838169 -0.0730878799472227 0.220631119162263 -0.331267321784604 0.740442572531653 0.955781054558401 hypothetical protein VI - Unknowns Rv2902c rnhB 629.6 355.9 285.9 611 436.8 496.9 591.298326044569 0.134209752815913 0.191639945151331 0.700322433874276 0.483725964681069 0.908019273666837 Probable ribonuclease HII protein RnhB (RNase HII) II.B.1 - RNA Rv2903c lepB 565.5 306.2 277.2 439.9 400.1 312.7 539.126318983989 -0.160968297881116 0.17774425752302 -0.905617431045664 0.365138379365445 0.883373818299354 Probable signal peptidase I LepB (SPASE I) (leader peptidase I) III.D - Protein and peptide secretion Rv2904c rplS 790.5 405.9 396.1 522.1 550.4 459.2 284.205689832061 -0.228358901022355 0.203813743580008 -1.12042935383654 0.262530841964348 0.806685286411718 50S ribosomal protein L19 RplS II.A.1 - Ribosomal protein synthesis and modification Rv2905 lppW 304 162.3 120.5 274.6 298.2 222.2 340.189282584359 0.296399049266026 0.19783154660408 1.49823955963509 0.134071020930521 0.680441181456551 Probable conserved alanine rich lipoprotein LppW II.C.1 - Lipoproteins(lppA-lpr0) Rv2906c trmD 15 6.2 6.1 18.8 8.8 8.3 10.6786230572813 0.270736889394646 0.665157696304927 0.407026620752701 0.683988436346417 NA Probable tRNA (guanine-N1)-methyltransferase TrmD (M1G-methyltransferase) (tRNA [GM37] methyltransferase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2907c rimM 28.5 25.5 7.8 49.9 22.7 26.6 21.4789576749892 0.582804557424387 0.515870587849724 1.12974953632007 0.258581777572448 NA Probable 16S rRNA processing protein RimM II.A.2 - Ribosome modification and maturation Rv2908c - 81.6 45.4 31.2 76.9 51.2 52.5 20.7246594997904 0.0769259509491521 0.481716014382797 0.15969149592777 0.873124100198123 NA hypothetical protein V - Conserved hypotheticals Rv2909c rpsP 161.5 89 73.6 147.9 142.1 114.1 93.0198480744811 0.138850773701741 0.262894005898628 0.528162569652813 0.597386506170173 0.930022694368295 30S ribosomal protein S16 RpsP II.A.1 - Ribosomal protein synthesis and modification Rv2910c - 44.6 27 9.9 83.8 32.3 15.8 22.6709519268186 0.659862405631194 0.556660157018151 1.18539542899184 0.235861138180711 NA hypothetical protein V - Conserved hypotheticals Rv2911 dacB2 27 21.6 14.8 32.9 40 21 35.6174106450793 0.375225853823198 0.38775041778321 0.967699418529021 0.333194508613392 0.853347384539607 Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase) II.C.3 - Murein sacculus and peptidoglycan Rv2912c - 22.3 9.9 12.7 19.7 19.8 11.7 14.3278691740384 0.0231429192683396 0.565420504083099 0.0409304563616221 0.967351337119978 NA Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv2913c - 20.4 10.2 10.1 18.2 8 8.9 36.1097206691109 -0.346130888004276 0.408228613721771 -0.847884926165861 0.396502060158471 0.893826103932853 Possible D-amino acid aminohydrolase (D-amino acid hydrolase) I.A.2 - Amino acids and amines Rv2914c pknI 31.7 29.4 19.3 32.6 41.9 28.6 86.0033118920189 0.167697505733375 0.293752234710556 0.570880782910853 0.568080458303974 0.92521033104044 Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2915c - 30.4 15.3 19.4 38.4 36.3 31.6 49.8531907584173 0.500652627854366 0.337477797127718 1.48351278844248 0.137938221275452 0.682181933169668 hypothetical protein V - Conserved hypotheticals Rv2916c ffh 58.5 19.9 24.9 57.9 41.2 39.2 98.1903468240497 0.270802221787183 0.289997584522541 0.933808542691963 0.350402662104205 0.866142773351413 Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein) III.D - Protein and peptide secretion Rv2917 - 1.4 0 0.6 2.5 1 0 2.08506288888302 0.74521541735449 1.51272441785927 0.492631313778276 0.622273118102711 NA Conserved hypothetical alanine and arginine rich protein V - Conserved hypotheticals Rv2918c glnD 86.7 55.7 43.7 82.7 65.4 40.1 239.490921070632 -0.151935527982308 0.222981363960108 -0.68138218048343 0.495629695262231 0.913636152872564 Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl-transferase) (uridylyl removing enzyme) (UTASE) I.D.1 - Glutamate family Rv2919c glnB 918.7 761.8 675.8 837.2 1064.2 938.6 482.245620403791 0.0452022603600475 0.227274141423562 0.198888708046226 0.842349802734008 0.974476040705366 Probable nitrogen regulatory protein P-II GlnB I.J.1 - Repressors/activators Rv2920c amt 117.7 119 84.3 142.7 165 152.6 304.302811494888 0.300499195566366 0.241435838209483 1.24463376189262 0.213266404138264 0.773070552038584 Probable ammonium-transport integral membrane protein Amt III.A.2 - Cations Rv2921c ftsY 113.5 61.9 48.1 121.3 64 45.1 148.440836490155 -0.0934738976912056 0.283633499940637 -0.329558735871359 0.741733406157529 0.955781054558401 Probable cell division protein FtsY (SRP receptor) (signal recognition particle receptor) III.C - Cell division Rv2922c smc 57.5 25.5 30.3 46.7 40.4 35.2 225.695183202528 -0.0613766041164706 0.223144514005968 -0.275053161803606 0.783275395570635 0.963989543249515 Probable chromosome partition protein Smc III.C - Cell division Rv2922A acyP 63 36.1 24.4 65.3 15.6 17.7 15.270275897412 -0.378669045877178 0.622851175802107 -0.607960714515034 0.543213529781523 NA Probable acylphosphatase AcyP (acylphosphate phosphohydrolase) ? Rv2923c - 45.9 8.3 33.7 43.2 21.6 27.8 19.2981560662265 -0.153627547308792 0.559451209626395 -0.274604013120975 0.78362048280489 NA hypothetical protein V - Conserved hypotheticals Rv2924c fpg 38.8 11.6 11.9 17.7 23.6 18.6 26.5681749608935 -0.24004876950589 0.464000468692332 -0.5173459634263 0.604914673726457 NA Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2925c rnc 479.5 297.8 221.5 347 272.9 218.7 353.228141856787 -0.410532576334415 0.19376145167255 -2.11875258360575 0.0341113818752795 0.388280173938367 Probable ribonuclease III Rnc (RNase III) II.B.1 - RNA Rv2926c - 461.3 247.1 154.6 405.7 302.3 141.9 273.776928956031 -0.152734356534271 0.263662177019477 -0.579280495446219 0.562399924020476 0.92521033104044 hypothetical protein VI - Unknowns Rv2927c - 637 373 275.7 599.1 511.1 464.6 555.090042570296 0.143381789236208 0.177433154933742 0.808089047899473 0.419039321918071 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv2928 tesA 92.5 65.6 37.8 58.3 54.6 71.9 79.7313403502648 -0.253642651484552 0.302647959557153 -0.838078181183487 0.401986796097949 0.893826103932853 Probable thioesterase TesA I.I - Polyketide and non-ribosomal peptide synthesis Rv2929 - 95.4 32.4 37.8 52 76.4 93 31.3049282821824 0.224761668626572 0.451723691731882 0.4975644907285 0.618791037087926 0.931582271037618 Hypothetical protein VI - Unknowns Rv2930 fadD26 596.3 386.4 314.4 419.6 626.2 488.3 1330.40588378549 0.0763100440895381 0.204609024896563 0.372955416449081 0.709181626287785 0.949890877982223 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2931 ppsA 165 105 78.3 168.4 172.7 153.2 1255.15339552149 0.34792594151969 0.167405442662336 2.07834306929597 0.0376777722404646 0.400833530835097 Phenolpthiocerol synthesis type-I polyketide synthase PpsA I.I - Polyketide and non-ribosomal peptide synthesis Rv2932 ppsB 95.9 74.9 54.4 133.8 103.2 99.3 689.42327795465 0.383504298770773 0.187916764332817 2.04082004142831 0.0412687177505345 0.412980187910782 Phenolpthiocerol synthesis type-I polyketide synthase PpsB I.I - Polyketide and non-ribosomal peptide synthesis Rv2933 ppsC 136.2 101.5 59.3 177.4 135.7 115.7 1249.99480637457 0.362403165144495 0.185577262623272 1.95284249816846 0.0508382610299538 0.461044688553614 Phenolpthiocerol synthesis type-I polyketide synthase PpsC I.I - Polyketide and non-ribosomal peptide synthesis Rv2934 ppsD 113 80.6 59.1 150.1 113.4 107.3 904.892803923166 0.371998863944124 0.177750762589705 2.09281163424764 0.036365972843084 0.398982485820102 Phenolpthiocerol synthesis type-I polyketide synthase PpsD I.I - Polyketide and non-ribosomal peptide synthesis Rv2935 ppsE 154.4 98.3 76.8 156.2 165.1 112.5 899.384441139126 0.220354985854609 0.170484846147867 1.29251948682576 0.196177301908551 0.751109817915875 Phenolpthiocerol synthesis type-I polyketide synthase PpsE I.I - Polyketide and non-ribosomal peptide synthesis Rv2936 drrA 267.7 207.1 154.9 266.3 312.5 250.1 389.258993126704 0.202116507924411 0.203804526913934 0.991717460769477 0.321335371011816 0.849868688356633 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA III.A.6 - Efflux proteins Rv2937 drrB 169.5 99 92.7 153.5 176.8 160.9 197.530522231567 0.257341760297506 0.22689749380739 1.1341763012859 0.256720602749508 0.801061876847584 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB III.A.6 - Efflux proteins Rv2938 drrC 213.3 112 65.5 240 182.7 173.5 210.143117722509 0.502551619776739 0.236902185998843 2.1213464859256 0.0338926551064176 0.388280173938367 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC III.A.6 - Efflux proteins Rv2939 papA5 134.3 108.4 72.2 102 135.8 114.1 228.042407484307 -0.0241113532012244 0.236464032835983 -0.101966260627672 0.918783455580319 0.9932884147079 Possible conserved polyketide synthase associated protein PapA5 I.I - Polyketide and non-ribosomal peptide synthesis Rv2940c mas 287.1 187.3 146.1 341.2 298.3 255.8 2536.94785837479 0.353184734526687 0.155080998739383 2.2774210728435 0.0227610928991501 0.313219815716663 Probable multifunctional mycocerosic acid synthase membrane-associated Mas I.I - Polyketide and non-ribosomal peptide synthesis Rv2941 fadD28 1013.2 744.6 584.4 728.3 954.8 927.1 2345.37365864199 -0.0163273629044792 0.207682002780903 -0.0786171294857164 0.937337162350343 0.998153412295216 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2942 mmpL7 448.4 272.2 271.3 363 346.9 299.2 1491.02775530384 -0.169851588468434 0.173234098058183 -0.980474342940192 0.326852028398673 0.853347384539607 Conserved transmembrane transport protein MmpL7 II.C.4 - Conserved membrane proteins Rv2943 - 17.7 9.4 12.8 22.9 14.5 9.1 27.8657744601561 0.0466888913660588 0.447785891546471 0.104266106296503 0.916958174529108 0.9932884147079 Probable transposase for insertion sequence element IS1533 IV.B.1.c - Others Rv2943A - 7.1 14.7 5.9 3.5 9.4 13.1 7.59481584745795 -0.378914328914406 0.868236207665303 -0.436418483321849 0.662533130972802 NA Possible transposase ? Rv2944 - 12.8 23.4 12.8 9.4 17.3 15.1 18.2511223176108 -0.525942013764206 0.588537927030917 -0.893641666251659 0.371513645601572 NA Possible transposase for insertion sequence element IS1533 IV.B.1.c - Others Rv2945c lppX 125.4 111.5 56.8 232.6 219.5 196.2 173.194992915872 0.99265560049443 0.241159860632325 4.11617255828425 3.85215946036303e-05 0.00332971033355129 Probable conserved lipoprotein LppX II.C.1 - Lipoproteins(lppA-lpr0) Rv2946c pks1 78.8 68.9 36.8 190.7 104.1 106 736.997014357375 0.929820093757376 0.234291435876497 3.96864738260222 7.22817469224836e-05 0.0052706368749394 Probable polyketide synthase Pks1 I.I - Polyketide and non-ribosomal peptide synthesis Rv2947c pks15 66.9 73 52.7 230.8 105.6 113.4 251.632525814848 0.975344512375916 0.289988914690798 3.36338550532486 0.000769927658840333 0.0401815076292898 Probable polyketide synthase Pks15 I.I - Polyketide and non-ribosomal peptide synthesis Rv2948c fadD22 215.3 252 117.5 380.9 343.7 297.6 906.378088147701 0.59536125595781 0.234210428405083 2.54199294203968 0.0110222399224551 0.217767968753648 P-hydroxybenzoyl-AMP ligase FadD22 I.A.3 - Fatty acids Rv2949c - 879.4 930.8 560 522 1266.3 1074.5 865.098216758044 0.0830982658158754 0.490820062542842 0.169304949323709 0.865556783184873 0.977876220223739 Chorismate pyruvate lyase VI - Unknowns Rv2950c fadD29 909.5 747.7 566 623.7 973.1 905 2405.16814318665 -0.0143907926215683 0.233043278908488 -0.0617515883271592 0.950760656780902 0.998153412295216 Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2951c - 170.4 115.8 77 196.1 170.5 154.7 266.765258753236 0.363394609943482 0.202034826287792 1.79867311304952 0.0720704044366371 0.54162997700187 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2952 - 176.9 171.5 86.3 185.5 256.7 220.1 238.642208888851 0.435401828075688 0.258335298113407 1.68541361267847 0.0919087990956353 0.588471616431776 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2953 - 83.4 60.3 32.9 83.8 119.1 97.5 157.750346118442 0.620797250096371 0.261581578621997 2.37324529260321 0.017632549685595 0.276757764055105 Enoyl reductase V - Conserved hypotheticals Rv2954c - 164.7 106.9 92.9 130.6 152.3 125 150.115337067111 -0.0344145001636096 0.237554976173479 -0.144869624362142 0.884813809639588 0.982420376752145 Hypothetical protein VI - Unknowns Rv2955c - 50.7 37.1 30.9 51.4 81.3 52.7 77.955218843843 0.443647632217203 0.307823430446427 1.44124062152707 0.149516715942594 0.695223866622759 hypothetical protein V - Conserved hypotheticals Rv2956 - 200.1 132.9 122.8 85.8 145.3 176.5 174.301277840206 -0.356438629650016 0.305874066925313 -1.16531170240415 0.243892843873396 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv2957 - 119.3 61.9 60.7 47.2 114.7 77.3 106.227064020355 -0.21383911201164 0.330706709107748 -0.646612560684304 0.517882726643785 0.915911629458156 Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2958c - 18.1 12.8 11.8 24.2 23.7 31.5 41.3318612433337 0.696091007192013 0.377306214477589 1.84489674562028 0.065052560180194 0.514454587842348 Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2959c - 50 43.5 39.9 32.7 56.3 70.2 59.7542679821791 -0.00464134114592299 0.387810463556403 -0.0119680658003906 0.990451093031383 0.999120249206713 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2960c - 74.7 67.7 39.4 43.4 98.3 106.5 28.7613067149205 0.212870773260614 0.484310581915566 0.439533599325164 0.660274941879411 0.939577115195416 Hypothetical protein VI - Unknowns Rv2961 - 1.4 1 2.6 1.5 0 2.1 0.424821471648299 -0.808054956491082 2.91529873984356 -0.277177410824952 0.781643883906758 NA Probable transposase V - Conserved hypotheticals Rv2962c - 16.2 8.4 6 15.5 16.4 13.6 26.1712215434001 0.39421266432486 0.43301833393368 0.910383310433309 0.362620396285088 NA Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2963 - 20.2 21.7 4.2 17.9 19.8 9 28.82467117533 -0.0917653962170895 0.47984044593249 -0.191241478276719 0.848336408304266 0.975474031954732 Probable integral membrane protein II.C.5 - Other membrane proteins Rv2964 purU 14.9 7.7 8.5 4.4 23.2 7.8 15.8531747140021 -0.0611509332053023 0.640445620703903 -0.0954818508058378 0.923932105350909 NA Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) I.F.1 - Purine ribonucleotide biosynthesis Rv2965c kdtB 90.4 94.2 42.7 104.8 99.4 85.7 66.7045573888046 0.186483200964265 0.321792417959561 0.579513967876335 0.562242424554497 0.92521033104044 Probable phosphopantetheine adenylyltransferase KdtB (pantetheine-phosphate adenylyltransferase) (PPAT) (dephospho-CoA pyrophosphorylase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2966c - 36.8 41 18.4 67.2 34.4 30.5 33.7125185235816 0.341300443130929 0.430554055174605 0.792700565768727 0.427952300606602 0.901158530199572 Possible methyltransferase (methylase) V - Conserved hypotheticals Rv2967c pca 52.7 35.8 29.7 58.2 52.4 41 242.597271724419 0.171817926530606 0.205455936096501 0.836276282861472 0.402999492502001 0.893902643352474 Probable pyruvate carboxylase Pca (pyruvic carboxylase) I.B.3 - TCA cycle Rv2968c - 63.4 31 32.7 90.2 73.7 62.9 58.2263652502713 0.656730964546186 0.3145007978926 2.08816947030594 0.0367825502111808 0.398982485820102 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2969c - 181.8 116.3 69.4 130.4 121.4 90.3 142.581887828855 -0.244505300871373 0.240791155622133 -1.01542475777253 0.309903396397168 0.844880251285152 Possible conserved membrane or secreted protein II.C.5 - Other membrane proteins Rv2970c lipN 136.9 100 70.7 128.2 83.1 91.5 184.384709755203 -0.19836660240667 0.234755704895829 -0.844991615836103 0.398115520195904 0.893826103932853 Probable lipase/esterase LipN II.B.5 - Esterases and lipases Rv2970A - 132.4 101.8 83.6 124 132.1 102.7 30.6121311555721 -0.0161023056998382 0.406686524607716 -0.0395939002782801 0.968416890500251 0.998153412295216 hypothetical protein ? Rv2971 - 127.3 84.2 77.3 67.9 99.5 68.5 121.243262515442 -0.510721568537618 0.269423697167703 -1.89560745363731 0.0580119709312201 0.497736055470808 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2972c - 18.4 12.1 7.5 14.5 24.4 16.8 17.1837038318342 0.356613227107553 0.532145197838929 0.670142713973139 0.502766818053464 NA Possible conserved membrane or exported protein VI - Unknowns Rv2973c recG 18.5 10.1 10.2 19.6 17 22.1 56.571721231572 0.397924195556037 0.32829891951621 1.21207890705954 0.225482177082507 0.778631338090157 Probable ATP-dependent DNA helicase RecG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2974c - 20.9 11.2 7.7 24 14.1 16.8 34.7060993668274 0.341014464580194 0.394075885578048 0.865352276199237 0.386845466380315 0.893826103932853 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2975c - 40.1 27.4 25.8 61.4 26.6 17.9 12.7266676395736 0.0746803843713398 0.631965559738045 0.118171604798045 0.905931688373906 NA hypothetical protein V - Conserved hypotheticals Rv2976c ung 32.9 9.8 17.9 32 25.1 37.1 27.3642743659133 0.391149985672277 0.453025360185349 0.863417415555375 0.387908007510933 0.893826103932853 Probable uracil-DNA glycosylase Ung (UDG) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2977c thiL 53.2 29.6 29.9 55 25.6 28.8 58.8807129825649 -0.176478178635831 0.343315258292137 -0.514041174615258 0.607223203721464 0.931582271037618 Probable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase) I.G.8 - Thiamine Rv2978c - 94.4 60.8 38.1 77.3 72.2 38.4 137.08116835113 -0.183075560257967 0.253665747266241 -0.721719673353518 0.4704668440794 0.902597484602108 Probable transposase IV.B.1.c - Others Rv2979c - 106.8 63.5 53.4 120.5 145.9 116.9 93.0517953187562 0.608222214194765 0.271940749421998 2.23659828652941 0.0253126070170037 0.334998425880538 Probable resolvase IV.B.1.c - Others Rv2980 - 32.5 12.6 11.1 17.6 36.9 15.4 16.8067211092364 0.115764667060616 0.562786569699923 0.205699057677126 0.837025994684694 NA Possible conserved secreted protein VI - Unknowns Rv2981c ddlA 88.6 72.5 54.3 88.1 79.7 46.4 128.74086808125 -0.198316460708356 0.25976872039281 -0.763434721503311 0.44520417929337 0.901158530199572 Probable D-alanine--D-alanine ligase DdlA (D-alanylalanine synthetase) (D-ala-D-ala ligase) II.C.3 - Murein sacculus and peptidoglycan Rv2982c gpdA2 74.5 52.8 28.8 76.8 48.4 63.4 90.9203448037922 0.126770832532818 0.289893947052001 0.437300722633157 0.661893271350608 0.939577115195416 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2983 - 35 24.6 27.3 19.8 38.9 59.3 36.3055459668528 0.165647076586456 0.471112225022347 0.351608529323557 0.725131867712069 0.949890877982223 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2984 ppk1 73.7 51.8 39.1 62 61.3 51.1 202.231148090551 -0.093053718360723 0.214042002085807 -0.434745131581319 0.663747435421451 0.939759692320761 Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase) I.A.4 - Phosphorous compounds Rv2985 mutT1 55.4 38.1 40 31.2 38.3 28.1 60.1976601457657 -0.715582550773866 0.329075292559457 -2.17452530455344 0.0296657071368614 0.364690426402483 Possible hydrolase MutT1 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2986c hupB 939.9 495.6 392.2 1029.7 1029.1 868.9 799.415691826271 0.543271748569316 0.173711981548035 3.12742819308114 0.00176342890612608 0.0706904978890541 DNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein) II.A.4 - Nucleoproteins Rv2987c leuD 453.9 219.6 254.8 211.6 388.5 270.4 288.964352577327 -0.268486902664682 0.262788920720224 -1.02168273277595 0.306931086203735 0.844880251285152 Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) I.D.7 - Branched amino acid family Rv2988c leuC 685.1 306.1 307.9 397.1 497.9 292.4 929.135791257188 -0.276353925801582 0.201164827822024 -1.37376860952094 0.169513529236006 0.725811798555406 Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) I.D.7 - Branched amino acid family Rv2989 - 816.6 274.3 316.4 395 415.4 203.2 439.306877069976 -0.592715802625144 0.248145162236144 -2.38858496085083 0.0169133971762304 0.276757764055105 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv2990c - 123.2 95.6 57.6 103.5 124.8 94.1 136.66707704975 0.0440664490435855 0.248724750720663 0.17716953747428 0.859375222691589 0.975793048425672 Hypothetical protein VI - Unknowns Rv2991 - 95.9 51.9 37 78.2 62.9 28.8 44.3816911325374 -0.243074021370783 0.368649141142721 -0.659364133108555 0.509661968290418 0.915911629458156 hypothetical protein V - Conserved hypotheticals Rv2992c gltS 111.3 94.7 44.2 108.4 117.4 73.8 213.124159809151 0.107035884227494 0.242809587446175 0.440822314115669 0.659341637869476 0.939577115195416 Glutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2993c - 151.8 166.9 76.8 127.6 188 150.5 167.452728316431 0.0472461824476019 0.287688222530103 0.164227030331971 0.869552422860811 0.977891032682394 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) V - Conserved hypotheticals Rv2994 - 36.8 20.2 13.9 46.9 44.2 30.1 65.4330534109749 0.626686014177635 0.304706845636782 2.05668505040632 0.0397165311097403 0.408386338474133 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv2995c leuB 120.9 59.5 57.6 101.1 63.7 57.6 122.405631173167 -0.242491674873721 0.262308691977299 -0.924451542363327 0.355251269806517 0.873942738060982 Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) I.D.7 - Branched amino acid family Rv2996c serA1 61.6 24.3 30.4 63.2 33.1 32.6 101.269478866115 -0.00579732215446702 0.302676172556971 -0.0191535465295863 0.984718615295719 0.999019127881181 Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH) I.D.3 - Serine family Rv2997 - 10.4 6.1 3.7 8.5 2.1 0 10.8930181919175 -0.923657078390028 0.764383303078009 -1.20836898800727 0.226905363010605 NA Possible alanine rich dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2998 - 8.6 0 8.9 23.7 6.6 16 7.34025748288641 1.10556769886235 0.87007698917845 1.27065502548947 0.203851402080198 NA Hypothetical protein VI - Unknowns Rv2998A - 1.6 0 0 0 2.4 8.3 0.550719322846364 0.978551676154883 2.93175070717682 0.333777245711726 0.738547654989786 NA hypothetical protein ? Rv2999 lppY 11.6 11.3 4.5 7.2 9.9 10 13.32223536101 -0.232235393475962 0.60440311596054 -0.38423923924827 0.700801137643563 NA Probable conserved lipoprotein LppY II.C.1 - Lipoproteins(lppA-lpr0) Rv3000 - 6.5 1.3 4.9 4.7 3.9 4.3 3.84368240736455 -0.343728272621269 1.10351576676114 -0.311484695529203 0.755432175816456 NA Possible conserved transmembrane protein V - Conserved hypotheticals Rv3001c ilvC 193.8 106.5 75.3 191.8 127.2 118 211.621952604167 0.0847721673379173 0.228332148706475 0.371266892630584 0.710438754416282 0.949890877982223 Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase) I.D.7 - Branched amino acid family Rv3002c ilvN 278.2 159.2 146.7 194.7 230.3 134.8 154.100469346994 -0.242783605895602 0.237102429885176 -1.02396085106836 0.305853766457434 0.844880251285152 Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS) I.D.7 - Branched amino acid family Rv3003c ilvB1 214.4 110.1 117.2 134.9 139 106.9 408.806782981092 -0.396453666776252 0.195862920839073 -2.02413843864807 0.0429559095694347 0.418767550294889 Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) I.D.7 - Branched amino acid family Rv3004 cfp6 122.3 88 77.7 116.5 82.1 61.7 49.7790287733527 -0.301031814770662 0.345499817712294 -0.871293700714303 0.383593809091677 0.893826103932853 Low molecular weight protein antigen 6 (CFP-6) VI - Unknowns Rv3005c - 231.1 126.5 81.5 216.3 219.6 150.5 222.291968434666 0.288241368095418 0.220849418365391 1.30514886672026 0.191842161753403 0.741700010610815 hypothetical protein V - Conserved hypotheticals Rv3006 lppZ 322.6 218.2 139.5 237.4 324.1 272 451.180406865232 0.145738859887116 0.215640900333256 0.675840527756506 0.499141900294295 0.915534811813011 Probable conserved lipoprotein LppZ II.C.1 - Lipoproteins(lppA-lpr0) Rv3007c - 20.8 17.7 2.3 20 14.6 13.8 13.7826140458477 0.223213409148066 0.625249109040412 0.356999163886276 0.72109243167145 NA Possible oxidoreductase VI - Unknowns Rv3008 - 89.3 53.4 39.6 55.3 60.8 49.2 57.3914791404511 -0.31823545526585 0.316232073941256 -1.00633516170459 0.314254371782143 0.846375455062714 Hypothetical protein VI - Unknowns Rv3009c gatB 139.6 71.6 77.7 104.4 100.6 79.1 233.529302275234 -0.205394243551796 0.214011114211872 -0.959736340368077 0.337187928635926 0.854445601186084 Probable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3010c pfkA 140 61.6 56.2 116.2 104.9 82.3 150.232450370124 0.0939019180722363 0.239238550271495 0.392503289982629 0.694686380934809 0.943825877173016 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) I.B.1 - Glycolysis Rv3011c gatA 23.5 9.7 7.1 30 11.4 13.1 34.8648963970416 0.361959165068409 0.441210043286745 0.820378344908096 0.412000456520822 0.901158530199572 Probable glutamyl-tRNA(GLN) amidotransferase (subunit A) GatA (Glu-ADT subunit A) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3012c gatC 11.8 12.7 1.7 12.3 36.3 9.4 5.41051666483938 1.14118726243219 0.988395321087048 1.15458586062214 0.248260059567415 NA Probable glutamyl-tRNA(GLN) amidotransferase (subunit C) GatC (Glu-ADT subunit C) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3013 - 18.1 5.2 6.8 9.1 0 0 6.21659202992868 -1.43825235404811 1.01154794648592 -1.4218331014803 0.155074707674157 NA hypothetical protein V - Conserved hypotheticals Rv3014c ligA 25.7 8.1 10.3 26 15.1 15.3 53.0371529702576 0.209619069684835 0.360054684840634 0.58218675804098 0.56044089184058 0.92521033104044 DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3015c - 15.7 9 7.3 18 7.7 13.5 18.6536498062188 0.206143654981293 0.517064853967017 0.398680462227748 0.690128665753209 NA hypothetical protein V - Conserved hypotheticals Rv3016 lpqA 43.1 27.1 29.2 27.8 28.9 46.9 34.725752573424 -0.20233564942042 0.420836361537028 -0.480794123115754 0.630662827500337 0.93413540068838 Probable lipoprotein LpqA II.C.1 - Lipoproteins(lppA-lpr0) Rv3017c esxQ 7.7 2.7 0.7 6.6 5.1 4.5 1.83186607310935 0.774195355682596 1.6119071836788 0.480297726520257 0.63101570523685 NA ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8) V - Conserved hypotheticals Rv3018c PPE46 3.4 0 1.3 3.6 0 2.2 2.92016492938281 0.121536296285706 1.32864045493276 0.0914741801173413 0.927115821488203 NA PPE family protein PPE46 IV.C.2 - PPE family Rv3018A PE27A 1.2 10.8 6.7 4.4 0 0 0.0743826405143542 1.17188358725511 4.01286532847697 0.292031626114871 0.770262443259805 NA PE family protein PE27A ? Rv3019c esxR 3.8 2.5 0 0.7 0 0 0.201603528343158 -1.28649479730926 4.0192243476037 -0.320085341361023 0.74890363747486 NA Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3020c esxS 4.2 2.7 0 6.8 0 0 0.670299763467412 0.773938261084786 2.64790789061981 0.292282924125289 0.770070313642266 NA ESAT-6 like protein EsxS IV.C.1.a - PE subfamily Rv3022A PE29 0.6 0 0 1.3 0 0 0.0967830325524829 0.745394649664457 4.00663173781962 0.186040219925501 0.852413220923028 NA PE family protein PE29 ? Rv3023c - 2.8 2.8 3.4 2.7 3 4.5 6.30703682881179 -0.109205209566134 0.861886388460138 -0.126704877845028 0.899173984996048 NA Probable transposase IV.B.1.b - IS1081 Rv3024c trmU 75.2 34.3 43.2 75.4 78.6 47.6 102.235796164423 0.205467848387367 0.274509897401371 0.748489764239521 0.454164796768358 0.901158530199572 Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU V - Conserved hypotheticals Rv3025c iscS 101.3 64.1 52.9 99.6 99 65.3 150.354995051352 0.0963581297824764 0.230626604885235 0.417810121388321 0.676085950161117 0.942092563297556 Cysteine desulfurase IscS (NIFS protein homolog) (nitrogenase metalloclusters biosynthesis protein NIFS) IV.H - Miscellaneous transferases Rv3026c - 6.8 5.7 5.1 9.8 11.8 8.6 11.1521584744008 0.523870356536173 0.637223986020397 0.82211336677368 0.411012378637813 NA hypothetical protein IV.H - Miscellaneous transferases Rv3027c - 13.1 3.7 7.7 22.3 18.6 18.9 18.2301805115953 1.04104113822319 0.520760244709054 1.99907951653417 0.0455997510144238 NA GCN5-related N-acetyltransferase VI - Unknowns Rv3028c fixB 249.9 169.4 128.3 242.9 196.6 152.4 288.85220921811 -0.0620642157955719 0.201260160523371 -0.308378049754983 0.75779468240916 0.959593750764785 Probable electron transfer flavoprotein (alpha-subunit) FixB (alpha-ETF) (electron transfer flavoprotein large subunit) (ETFLS) I.B.6.c - Electron transport Rv3029c fixA 477.7 336 233.1 347.7 307 344 440.95293135935 -0.233780316218723 0.200316874695306 -1.16705253401301 0.243189154842879 0.78958848015113 Probable electron transfer flavoprotein (beta-subunit) FixA (beta-ETF) (electron transfer flavoprotein small subunit) (ETFSS) I.B.6.c - Electron transport Rv3030 - 34.9 33.5 24.7 43.6 43.2 43.9 49.6225942281086 0.307930285762915 0.351289727653896 0.876570709366999 0.380719854413702 0.893490749801147 hypothetical protein V - Conserved hypotheticals Rv3031 - 25.9 20.3 13.7 37.8 26 26.4 62.4284488827042 0.438080710572482 0.313320664947761 1.39818645746051 0.162057082431433 0.718349182700872 hypothetical protein V - Conserved hypotheticals Rv3032 - 45 34 19.7 59.6 38.4 56.6 83.1108351273588 0.502572198748396 0.299067213785878 1.68046571333032 0.0928667398692762 0.591864982669166 Alpha (1->4) glucosyltransferase V - Conserved hypotheticals Rv3032A - 18.3 7.2 9.5 32.2 6.1 1 6.65078129918589 0.186144168815651 0.926241208098793 0.200967272010853 0.840724165102254 NA hypothetical protein ? Rv3033 - 16.5 17.9 12 14.7 6.5 33 15.0416729149065 -0.0576459594227799 0.633928822630653 -0.0909344351682307 0.927544688225059 NA hypothetical protein VI - Unknowns Rv3034c - 64.2 35.2 25.4 47 57.6 74 71.9856694933958 0.352165680795939 0.328990326002316 1.07044387923267 0.284419557295483 0.828109995241374 Possible transferase V - Conserved hypotheticals Rv3035 - 32 17.7 11.2 28.3 13.3 11.1 31.3344400366884 -0.258746338028236 0.434416802949668 -0.595617702334168 0.551430647953773 0.92521033104044 hypothetical protein VI - Unknowns Rv3036c TB22.2 54.8 32.6 24 36.4 63.5 63.1 49.5269307178994 0.365751699646481 0.375588648883044 0.973809247787927 0.330151260515466 0.853347384539607 Probable conserved secreted protein TB22.2 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3037c - 55 34.3 24.4 72 48.7 31.1 73.2458431197562 0.286294496991566 0.30894061269591 0.926697511516124 0.354083609934292 0.872901305773842 hypothetical protein VI - Unknowns Rv3038c - 199.4 130.2 82.5 211.9 215.7 142.1 251.713837788378 0.317416944812706 0.209801674283775 1.51293809211156 0.130295384906168 0.67528835585222 hypothetical protein VI - Unknowns Rv3039c echA17 80.3 46.9 32.6 84.7 73.7 45.9 71.3193867116334 0.214997016415442 0.297619081077851 0.722389893943672 0.470054798496912 0.902597484602108 Probable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase) I.A.3 - Fatty acids Rv3040c - 45 26 19 57.7 19.4 22.2 41.9125432984602 0.0471408830258435 0.413191619233958 0.114089639846135 0.909166734803343 0.992797152967251 hypothetical protein VI - Unknowns Rv3041c - 61 30.2 28.7 80.9 38.9 32.6 60.3171075122956 0.207820541972197 0.349846939011859 0.594032757751676 0.552490203469676 0.92521033104044 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv3042c serB2 184 93 75.3 198.5 111.6 83.5 236.310344384138 0.0186599932996513 0.254181432216071 0.0734121022805043 0.941478187355242 0.998153412295216 Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase) I.D.3 - Serine family Rv3043c ctaD 176 109.6 73.9 153.8 143.3 132.8 358.134374649086 0.111345767458917 0.193294109214742 0.576043253005792 0.564585946350509 0.92521033104044 Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) I.B.6.a - aerobic Rv3044 fecB 141.5 75.7 68.7 131 124.1 110.7 185.530667991349 0.184012752960265 0.217527706332402 0.845927886901346 0.397592974427248 0.893826103932853 Probable FEIII-dicitrate-binding periplasmic lipoprotein FecB III.A.2 - Cations Rv3045 adhC 402.2 267.4 250.4 252.5 369.9 258.6 509.204717941278 -0.267023928534602 0.217102893522251 -1.22994182252681 0.218718891397907 0.773070552038584 Probable NADP-dependent alcohol dehydrogenase AdhC I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3046c - 48.9 18.5 21.7 35.7 24.6 33.5 17.3606031021028 -0.0943825895464694 0.529534167114624 -0.178237015489955 0.858536840959081 NA hypothetical protein V - Conserved hypotheticals Rv3047c - 49.1 42.6 15.5 58.1 62.3 67.2 21.4768943111933 0.709694628768116 0.491373644368299 1.44430747741973 0.148652503372359 NA Hypothetical protein VI - Unknowns Rv3048c nrdF2 180.8 153.2 76.1 139 138.8 152.1 219.704340367827 -0.087182544937906 0.246421475493113 -0.35379442787381 0.723492949681991 0.949890877982223 Ribonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3049c - 334.1 197.9 151.8 178.1 254.1 136.3 523.647022188118 -0.429717798809425 0.210808321374308 -2.03842901460434 0.0415070470857546 0.412980187910782 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3050c - 398.7 215.8 184.5 327.8 366.3 306.4 351.560952260834 0.166213948607395 0.196437980111735 0.846139572972864 0.397474886854256 0.893826103932853 Probable transcriptional regulatory protein (probably AsnC-family) I.J.1 - Repressors/activators Rv3051c nrdE 908.2 660.4 480.5 511.7 844.1 784.6 2368.87592569387 -0.0895608570050953 0.233899341788904 -0.382903416145243 0.701791378338368 0.947279830180307 Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3052c nrdI 860.3 568.2 554.4 518 826.4 642.3 490.186996545021 -0.198029100260826 0.234388269522074 -0.844876327064551 0.398179893046978 0.893826103932853 Probable NrdI protein I.F.3 - 2'-deoxyribonucleotide metabolism Rv3053c nrdH 2272.5 1885.9 1485.5 884.4 1728.4 1692.1 666.02662433893 -0.578909872800131 0.278158979361714 -2.08121943116323 0.0374138257741759 0.399823674443666 Probable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH I.F.3 - 2'-deoxyribonucleotide metabolism Rv3054c - 2.1 0 0 6.7 0 0 1.04221296603918 1.48616035961607 2.26018370060005 0.657539632385418 0.51083399619599 NA hypothetical protein V - Conserved hypotheticals Rv3055 - 37.3 28.2 21.9 32.1 26 23 27.242332315184 -0.261146276478516 0.425738143270803 -0.613396475289286 0.539614216076325 0.925170967849126 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3056 dinP 42.3 36.9 28.1 38.5 42.7 19 57.9372671998181 -0.293872997230346 0.339042179741862 -0.866774150207781 0.38606576820777 0.893826103932853 Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3057c - 58.3 32 26.3 56.3 42 47.1 58.7379947923263 0.144646363065037 0.314456011225101 0.459989181003422 0.64552398618568 0.939577115195416 Probable short chain alcohol dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3058c - 134.9 106.9 93.2 108 120.2 62.3 110.176879887738 -0.426470730056727 0.27708298268337 -1.53914443220812 0.123769039838399 0.666956030977941 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3059 cyp136 69.6 62.9 49.6 37.2 48.9 36.6 125.011156181381 -0.814268709671785 0.277214798254149 -2.93732049948238 0.0033106176378239 0.104058731661601 Probable cytochrome P450 136 Cyp136 IV.F - Cytochrome P450 enzymes Rv3060c - 237.9 153.4 111.1 158.8 226.2 194.5 425.427861629147 0.0500549700599621 0.21969273618662 0.227840805885555 0.819770002364511 0.967203057682185 Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv3061c fadE22 90.5 43.1 57.4 78.6 57.9 53.6 221.518990140003 -0.203859039694433 0.239229350722275 -0.852148948609137 0.394131427200158 0.893826103932853 Probable acyl-CoA dehydrogenase FadE22 I.A.3 - Fatty acids Rv3062 ligB 15.5 10.6 13.8 9.2 13.1 10.6 30.4612868008544 -0.548937605857423 0.440558583818532 -1.24600365540382 0.212763053191486 0.773070552038584 Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3063 cstA 12.5 10 5.6 12.4 10.5 9.9 36.4047537957311 0.0728156223203329 0.380086948535036 0.191576223811381 0.848074168173436 0.975474031954732 Probable carbon starvation protein A homolog CstA III.E - Adaptations and atypical conditions Rv3064c - 43.5 20.9 16 45.3 39.2 49.9 23.2961207713272 0.583986789035531 0.464485207327122 1.25727747584488 0.208653177190848 NA Probable conserved integral membrane protein V - Conserved hypotheticals Rv3065 mmr 62.3 36.9 30.3 55.6 36.3 7.6 18.7408208120138 -0.486219292191876 0.550974750878078 -0.882471095847854 0.377522103690013 NA Multidrugs-transport integral membrane protein Mmr III.A.6 - Efflux proteins Rv3066 - 32.8 11 13.8 17.1 13.8 9.1 14.9966686841229 -0.696276114121201 0.573564555451125 -1.21394550535564 0.224768534416075 NA Probable transcriptional regulatory protein (probably DeoR-family) I.J.1 - Repressors/activators Rv3067 - 34.9 28.9 15.6 30.2 19.3 13.8 15.2385677664872 -0.434858617733362 0.562009943259999 -0.773756092660777 0.439075042053357 NA hypothetical protein V - Conserved hypotheticals Rv3068c pgmA 40.2 29.5 19.3 25.4 34.5 37.9 82.2619458835128 -0.0564423126259093 0.31041370068899 -0.181829321646019 0.855716672738775 0.975712312098852 Probable phosphoglucomutase PgmA (glucose phosphomutase) (PGM) I.A.1 - Carbon compounds Rv3069 - 23.9 8.3 9.6 20.4 7.4 4.9 7.25611785466968 -0.486967302753153 0.822435685299091 -0.592103810009241 0.553781075774629 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3070 - 26.4 18 23.4 18.2 21.7 27.6 13.7473811474581 -0.284823327724054 0.604547221871601 -0.471134954259283 0.637544365162164 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3071 - 13.5 7.9 9.1 6.8 7.8 10.4 16.0513315073256 -0.644770156871032 0.557474926984665 -1.15659041449369 0.247439740362581 NA hypothetical protein VI - Unknowns Rv3072c - 40.3 18.7 13.7 38.6 5.2 12.3 16.5976196277081 -0.45927386894434 0.637254590158274 -0.720707039285932 0.471089780510504 NA hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3073c - 66.7 34.6 28 49.1 43.9 29 23.2218457929304 -0.228798833747909 0.454680287561645 -0.50320816628077 0.614817923920464 NA hypothetical protein V - Conserved hypotheticals Rv3074 - 139.5 89.3 63.9 232.5 222.1 115.5 282.660557403379 0.790422229003098 0.223022732919326 3.54413300678643 0.000393906473074112 0.0222356184596529 hypothetical protein V - Conserved hypotheticals Rv3075c - 332.1 176.3 130.4 315.5 247.6 208.7 338.930311423874 0.13738000014272 0.199920062833324 0.687174654688136 0.491972674005962 0.912135536464192 hypothetical protein V - Conserved hypotheticals Rv3076 - 28 9 2 32.7 27.3 5.9 11.0716461923678 0.66431572317691 0.759744655621377 0.874393413973517 0.381904042810174 NA hypothetical protein V - Conserved hypotheticals Rv3077 - 16.1 10.7 4.7 18.7 14.7 10.6 34.6891919162735 0.391099639749246 0.397712400525009 0.983373008316981 0.325423889683619 0.853347384539607 Possible hydrolase I.C.5 - Sulphur metabolism Rv3078 hab 25.2 10.2 6.1 20.3 25.4 1.7 8.28845382752979 0.0912942590897829 0.793597015175075 0.115038561567224 0.908414557213128 NA Probable hydroxylaminobenzene mutase Hab II.C.5 - Other membrane proteins Rv3079c - 20.5 14.3 10.1 8.4 15.7 12.8 17.8601778671695 -0.591627287791873 0.539079163415221 -1.09747756534262 0.272432682634374 NA hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3080c pknK 22.2 16 6.8 15.7 11.9 4.4 65.7859570242502 -0.602618054668817 0.363602076243479 -1.65735592297687 0.0974475371673383 0.611201559648203 Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv3081 - 9.8 18 3 11.6 6 9.1 18.55663429661 -0.346107099539052 0.605614987061189 -0.571496919550444 0.567662847861882 NA hypothetical protein VI - Unknowns Rv3082c virS 3.6 5.1 2.4 7.5 6.9 5.6 8.00957277133769 0.76969648118881 0.758063908809009 1.0153451077734 0.309941349353137 NA Virulence-regulating transcriptional regulator VirS (AraC/XylS family) I.J.1 - Repressors/activators Rv3083 - 64.3 45.3 26.3 33.4 41.2 18.6 90.0156981911278 -0.695010993409777 0.292014297501813 -2.3800580976877 0.017309908695874 0.276757764055105 Probable monooxygenase (hydroxylase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3084 lipR 22 19 12.9 15.3 6.6 7 20.3599616529929 -1.07358157606915 0.527830269031306 -2.03395227416462 0.0419564076412945 NA Probable acetyl-hydrolase/esterase LipR II.B.5 - Esterases and lipases Rv3085 - 29.9 19.1 7.7 15.8 26.9 18.7 25.0430058188434 -0.0256082644539782 0.478668105509947 -0.053498998908015 0.957334328264482 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3086 adhD 109.3 62.9 52.1 62.2 83 59 125.849570093228 -0.321029637599787 0.253069341481152 -1.26854416943941 0.204603687686256 0.765810284357488 Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3087 - 38.6 9.7 15.6 25.3 19.4 8 41.403030774531 -0.41151085208634 0.423181085692064 -0.97242260110317 0.330840352658386 0.853347384539607 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3088 tgs4 40.5 19.2 28.3 22.7 22.5 17.9 58.4514897206062 -0.704155648346397 0.336417698956798 -2.09309929450776 0.0363402916868492 0.398982485820102 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4 V - Conserved hypotheticals Rv3089 fadD13 47.7 33.1 23.5 32.1 19.6 24.3 72.9438498662784 -0.624630045653358 0.302954041936069 -2.06179802606882 0.0392269690891592 0.406373769665222 Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) I.A.3 - Fatty acids Rv3090 - 3.4 3.9 3.5 1.2 6.6 3.2 4.69856445720306 -0.385109729975845 1.02870724001624 -0.374362807021527 0.70813441015365 NA Unknown alanine and valine rich protein VI - Unknowns Rv3091 - 73.6 38.9 42.5 51.5 50.8 51.3 140.293903056749 -0.205416834879044 0.247697256350353 -0.829306056537399 0.406931244612735 0.899737667944704 hypothetical protein VI - Unknowns Rv3092c - 239 192.2 80.8 296.5 254.7 233.9 311.657199319366 0.481852442711341 0.236338749028519 2.03882116111733 0.0414678795564011 0.412980187910782 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3093c - 98.7 112.3 56 154.3 112.7 70.8 161.358423666499 0.135885648354201 0.286176936644197 0.474830885911493 0.634907516684986 0.934597866696866 Hypothetical oxidoreductase VI - Unknowns Rv3094c - 153.6 141.8 67.5 165.4 130.7 102.6 228.519371566847 -0.0311107914846293 0.243397731905355 -0.127818740302505 0.898292419095956 0.98854987613174 hypothetical protein V - Conserved hypotheticals Rv3095 - 297.5 343.8 163 257.8 349.3 246.6 214.541860871605 -0.114742687423216 0.2723625824572 -0.421286530580047 0.673545864632547 0.941398616257517 Hypothetical transcriptional regulatory protein I.J.1 - Repressors/activators Rv3096 - 104.8 85.3 47.2 71.9 96.6 90 151.28850420092 -0.0439623617422071 0.26613299456596 -0.165189445276809 0.868794872588502 0.977876220223739 hypothetical protein VI - Unknowns Rv3097c lipY 5.6 2.7 0.7 0.3 4.2 2.2 4.61850228467896 -0.750902952515694 1.1269740386413 -0.666300133604671 0.505219280213302 NA PE-PGRS family protein, triacylglycerol lipase LipY (esterase/lipase) (triglyceride lipase) (tributyrase) IV.C.1.a - PE subfamily Rv3098c - 11.1 4.8 0 8.4 3.8 1.5 2.71937924035742 -0.402811683271654 1.36733929672362 -0.294595265591255 0.768303079265956 NA Hypothetical protein VI - Unknowns Rv3098A - 349.5 212.5 174.7 341.1 339.6 207.3 136.818327027831 0.105272279235133 0.238729589107175 0.44096871120518 0.659235648697149 0.939577115195416 PemK-like protein ? Rv3099c - 126.1 103.9 74.7 93.5 104.9 111.8 142.612344007877 -0.171329168868006 0.260658157658431 -0.657294482578664 0.510991583486786 0.915911629458156 hypothetical protein VI - Unknowns Rv3100c smpB 54.9 22.9 27.4 69.9 57.7 31.7 32.5001088830904 0.464456568614871 0.407163967161377 1.14071137446892 0.253990051604069 0.79743074090449 Probable SSRA-binding protein SmpB IV.A - Virulence Rv3101c ftsX 59.2 40.2 41.4 61.8 53.7 74.8 80.177003474371 0.224603726180538 0.308807347289645 0.727326367561687 0.467026049250281 0.901461306508219 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) III.C - Cell division Rv3102c ftsE 33 29.1 24.1 27.2 20.1 23 29.2546097224491 -0.495267854547059 0.428741701307541 -1.15516604294994 0.248022437411381 0.794016275323935 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) III.C - Cell division Rv3103c - 58.9 30 40.8 47.9 41.9 42.8 30.6158206365115 -0.166679875391556 0.415160402817103 -0.401483075602916 0.688064496200839 0.942913432418385 Hypothetical proline-rich protein VI - Unknowns Rv3104c - 160.1 79.7 63.5 165.8 109.9 83.7 158.005865977778 0.107774860962481 0.251583075821497 0.428386768905507 0.668369555980072 0.940354944889996 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3105c prfB 75.4 70.2 52.8 66.1 59.3 67.9 122.433655086672 -0.261597867303047 0.274783809865025 -0.952013393480294 0.341090189385956 0.855368447926409 Probable peptide chain release factor 2 PrfB (RF-2) II.A.6 - Protein translation and modification Rv3106 fprA 19.2 9.3 3.9 12.5 8.8 8.3 20.7437723690902 -0.268745164063153 0.511135972240523 -0.525780181123099 0.599040946247357 NA NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) I.B.6.c - Electron transport Rv3107c agpS 19.5 12.2 9.2 15 18.3 20 39.1436203627714 0.184233290697011 0.378410825736627 0.486860518164026 0.62635717985438 0.93413540068838 Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3108 - 1.3 2.7 0.3 0.5 0 0 0.447148807808801 -1.7215345406199 3.08756139507361 -0.557570950124817 0.577137397908215 NA Hypothetical protein VI - Unknowns Rv3109 moaA1 11.8 8.8 5.7 7.9 23.9 22.8 22.9264974371752 0.852144385878496 0.544498371167756 1.56500814511336 0.117580999492197 NA Probable molybdenum cofactor biosynthesis protein A MoaA1 I.G.4 - Molybdopterin Rv3110 moaB1 13.5 9.2 12.8 15.4 12.1 6.6 6.77716405280157 -0.227354201101383 0.815172163713809 -0.278903293343077 0.780319041070162 NA Probable pterin-4-alpha-carbinolamine dehydratase MoaB1 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) I.G.4 - Molybdopterin Rv3111 moaC1 10.4 15 1.8 9.4 5.4 2.3 5.21395948091075 -0.839087192924293 1.02640159619578 -0.817503788024355 0.413640585416659 NA Probable molybdenum cofactor biosynthesis protein C MoaC1 I.G.4 - Molybdopterin Rv3112 moaD1 21.8 9 13.2 4.2 12.5 9.7 4.31408457193415 -1.4960271845301 1.07226434972808 -1.39520369665325 0.162954422606578 NA Probable molybdenum cofactor biosynthesis protein D MoaD1 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) I.G.4 - Molybdopterin Rv3113 - 7.6 4.9 5.8 5.9 13.5 9.4 8.0333231669783 0.280857950347592 0.768162151866106 0.365623260226113 0.714646215992301 NA Possible phosphatase VI - Unknowns Rv3114 - 6.6 2.7 0 5.9 13.2 0 3.28256022433323 0.996996603496384 1.2582253739615 0.792383164517939 0.428137292885886 NA hypothetical protein VI - Unknowns Rv3115 - 2 4.1 3.4 4.4 5.6 0 6.50724614795176 -0.0925543353882382 0.907478983351421 -0.101990610346065 0.918764128076861 NA Probable transposase IV.B.1.b - IS1081 Rv3116 moeB2 156.1 124.1 63.4 121.7 194.7 186 264.116220351192 0.410388614569478 0.271282032257866 1.51277477226868 0.130336879031585 0.67528835585222 Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) I.G.4 - Molybdopterin Rv3117 cysA3 147.6 91.6 89.5 86.5 118.2 133.3 151.338249531038 -0.165236614721182 0.277927466331899 -0.594531432614356 0.552156725321028 0.92521033104044 Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.D.3 - Serine family Rv3118 sseC1 165.1 83.1 53.8 199.6 91.3 72.9 51.1370994692113 0.187185519110419 0.379367306361886 0.493414999055979 0.621719386432365 0.931582271037618 Conserved hypothetical protein SseC1 I.C.5 - Sulphur metabolism Rv3119 moaE1 90.5 93 33.2 65.4 68.2 38.3 45.4065694977336 -0.445703333067473 0.381951289018693 -1.1669114514905 0.243246130844051 0.78958848015113 Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) I.G.4 - Molybdopterin Rv3120 - 58.6 22.4 37.9 96.3 67.8 55.2 52.5763127629115 0.674831529432361 0.350476331695156 1.92546962063997 0.0541706330187327 0.484906054789044 hypothetical protein IV.H - Miscellaneous transferases Rv3121 cyp141 63.5 45 38.3 50.9 63.4 60.9 104.507501510985 0.0479861365968456 0.276915774911502 0.173287840362945 0.862425181087799 0.976768531807831 Probable cytochrome P450 141 Cyp141 IV.F - Cytochrome P450 enzymes Rv3122 - 89.9 85.9 60.1 69.3 101 79.7 62.4747228703038 -0.150227207057459 0.338080912855007 -0.444352820124711 0.656787518337308 0.939577115195416 Hypothetical protein VI - Unknowns Rv3123 - 22.9 5.7 2.2 23 9.6 4 7.23193626150719 0.342515463332221 0.897478471493516 0.381641982745539 0.702726939343207 NA Hypothetical protein VI - Unknowns Rv3124 moaR1 4.3 2.4 3 3.9 15.6 2.6 6.89211593817986 0.900092887887278 0.872697022844502 1.03139218345616 0.302356944889411 NA Transcriptional regulatory protein MoaR1 I.J.1 - Repressors/activators Rv3125c PPE49 18.4 13.2 12.4 12.7 2.5 5.1 20.3771899261356 -1.25741067666097 0.57039745084305 -2.20444652198658 0.0274929569790995 NA PPE family protein PPE49 IV.C.2 - PPE family Rv3126c - 16.7 6 8.3 5.1 2.7 9 3.18996264208719 -1.73749407306086 1.27628185232134 -1.36137176118319 0.173396235448278 NA Hypothetical protein VI - Unknowns Rv3127 - 4587.1 2008.9 3045.6 823.1 65.1 810.2 3334.82647148827 -2.65759745988583 0.981476674947441 -2.70775406866204 0.00677401989258434 0.161525336404209 hypothetical protein V - Conserved hypotheticals Rv3129 - 12.6 6.8 4.3 10.5 9.8 21 5.30120217844312 0.484571428610734 0.935086069178028 0.518210509794771 0.604311402788034 NA hypothetical protein V - Conserved hypotheticals Rv3130c tgs1 4990.7 2197.8 3021.2 1104.1 37.8 792.3 4737.71335866808 -2.56415082478536 1.11990780361106 -2.28960885576246 0.0220440011721761 0.307948016374944 Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1 V - Conserved hypotheticals Rv3131 - 3489.5 1431.9 2490.8 844.6 42.1 486.8 2496.33775452318 -2.64703312956703 1.04092142915783 -2.54297111714633 0.0109914314377506 0.217767968753648 hypothetical protein V - Conserved hypotheticals Rv3132c devS 1016.4 478 628.5 241.3 51.3 147.7 1247.69916826255 -2.46070244673622 0.615837701660584 -3.99569958140112 6.45034890775219e-05 0.00509761859395502 Two component sensor histidine kinase DevS I.J.2 - Two component systems Rv3133c devR 2048.3 907.6 1342.8 487.2 47.1 232.8 933.0666623223 -2.70884809845075 0.851844231804572 -3.17998056136654 0.0014728493191293 0.0617257760107824 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) I.J.2 - Two component systems Rv3134c - 3071 1413.1 2011.2 759.7 51.9 345.6 1741.42027675361 -2.71356189269073 0.936900770201681 -2.89631728246589 0.00377570444654202 0.114764818671816 Universal stress protein family protein V - Conserved hypotheticals Rv3135 PPE50 251.4 141.4 147.7 209 189.7 211.9 123.072970156863 -0.0211965748388245 0.255538039915602 -0.0829488042008355 0.933892247579309 0.998010361628995 PPE family protein PPE50 IV.C.2 - PPE family Rv3136 PPE51 194.6 101.1 95.9 213.3 141.5 111.6 256.329391564116 0.089509813598184 0.22512816860028 0.397594908512363 0.690928814201118 0.942913432418385 PPE family protein PPE51 IV.C.2 - PPE family Rv3136A - 13.6 5.2 3.1 8.3 15.8 9.2 3.64121763026623 0.350228976254342 1.10123386057044 0.318033243250368 0.750459720546269 NA hypothetical protein ? Rv3137 - 55.5 29.3 27.2 60.6 46.2 34.8 51.6927490201549 0.177863344189979 0.329958625479507 0.539047415206988 0.589854138092789 0.928941202821899 Probable monophosphatase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3138 pflA 50.3 42.5 26.6 39.4 50.2 36.1 71.5159345989747 -0.109086546576194 0.30452919258215 -0.35821375826479 0.720183351890237 0.949890877982223 Probable pyruvate formate lyase activating protein PflA (formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3139 fadE24 651.6 303.4 409.2 289.9 334.3 236.5 853.821434021914 -0.861693256051362 0.21441617267918 -4.01878853299312 5.84981427889578e-05 0.00475899596924286 Probable acyl-CoA dehydrogenase FadE24 I.A.3 - Fatty acids Rv3140 fadE23 951.4 464 507.8 347 412.8 330.7 985.415301057704 -0.983907490095898 0.194377579644373 -5.06183630795293 4.15237476928092e-07 6.75615800695943e-05 Probable acyl-CoA dehydrogenase FadE23 I.A.3 - Fatty acids Rv3141 fadB4 242 158.5 149.5 150.9 159.4 78.1 246.501172074716 -0.709098482734811 0.232517069637967 -3.0496620477752 0.00229099002472078 0.081242030876637 Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) I.A.3 - Fatty acids Rv3142c - 384.4 268.4 151.6 250.2 411.8 335 204.81586019832 0.161880636026611 0.26441404630485 0.612224041380822 0.540389537385496 0.925170967849126 Hypothetical protein VI - Unknowns Rv3143 - 7 4.5 3.9 8 10.2 18.1 4.89052762767673 1.08252612153193 0.978394567375296 1.10643104288281 0.268539995388728 NA Probable response regulator I.J.2 - Two component systems Rv3144c PPE52 77.5 72.3 49.2 76.7 103.3 93.1 157.468068178635 0.246932946194776 0.268661106468421 0.919124280550825 0.358030570557663 0.877159041773689 PPE family protein PPE52 IV.C.2 - PPE family Rv3145 nuoA 386.1 344.1 165.9 331 372.9 250.7 190.179823100967 -0.0698162456178262 0.246926442524611 -0.282741066141054 0.777375333893255 0.963013023606306 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) I.B.6.a - aerobic Rv3146 nuoB 246.9 197.5 123.4 274.7 232.9 200.9 187.660092437155 0.15179490438279 0.224916044820124 0.674895846155339 0.499741939786801 0.915911629458156 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) I.B.6.a - aerobic Rv3147 nuoC 213.5 220 146.4 193.7 191.4 214.4 230.713331422766 -0.173232393756469 0.254365618228283 -0.681036985120372 0.495848088203541 0.913636152872564 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) I.B.6.a - aerobic Rv3148 nuoD 335.5 357.5 178.5 318.6 361.8 303.9 664.728553651704 -0.0241068556614386 0.230648178909902 -0.104517866888754 0.916758390204743 0.9932884147079 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) I.B.6.a - aerobic Rv3149 nuoE 371.5 225 195.5 315.1 306.7 215 328.684169647681 -0.097153875641402 0.192640450121459 -0.504327494979101 0.614031259304194 0.931582271037618 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) I.B.6.a - aerobic Rv3150 nuoF 287.3 208.7 120.2 261.2 233.1 189.7 459.033854053766 -0.00257944784383166 0.194425968050412 -0.0132669924172004 0.989414782105752 0.999120249206713 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) I.B.6.a - aerobic Rv3151 nuoG 333.5 225.8 159.9 344.8 279 221.8 1001.31482930975 0.059634511305587 0.171740267245173 0.347236628090568 0.72841355549557 0.949890877982223 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) I.B.6.a - aerobic Rv3152 nuoH 278.9 218.3 144.3 197.4 204.6 193.6 412.417850304753 -0.288077222562155 0.202521162996307 -1.42245490940326 0.154894232520173 0.705807023060417 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) I.B.6.a - aerobic Rv3153 nuoI 433.6 292.5 275 271.7 353.5 340.8 341.526601590928 -0.251886630057864 0.230569950725905 -1.09245211383724 0.274634427481757 0.815063118470535 Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) I.B.6.a - aerobic Rv3154 nuoJ 331.1 217.4 149.1 296.8 208.6 154 281.750909195636 -0.237522841657826 0.218174065978288 -1.08868503959341 0.276292801286598 0.818634530362941 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) I.B.6.a - aerobic Rv3155 nuoK 425.8 312 332.8 263.3 393.3 588.1 193.731628747278 0.00472583438246594 0.325199924320432 0.0145320894288075 0.988405478301636 0.999120249206713 Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K) I.B.6.a - aerobic Rv3156 nuoL 341.9 243.7 130.3 315.3 219.7 187.6 718.728836867527 -0.135345445446414 0.20727128102881 -0.652986968453199 0.513764679775361 0.915911629458156 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) I.B.6.a - aerobic Rv3157 nuoM 263.8 193.9 137.3 229.4 219 181.1 544.934974657391 -0.0988120628739776 0.181137259731693 -0.545509317190407 0.585403274224438 0.928941202821899 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) I.B.6.a - aerobic Rv3158 nuoN 284.4 173.4 124.4 225.6 169.9 155.9 478.264278190175 -0.229773720303177 0.187067114792953 -1.22829563366865 0.219336009484209 0.773070552038584 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) I.B.6.a - aerobic Rv3159c PPE53 28.4 28 29.5 22.3 34.8 33.1 87.4875370839814 -0.213010073997549 0.348039780225911 -0.612027952262485 0.540519263934992 0.925170967849126 PPE family protein PPE53 IV.C.2 - PPE family Rv3160c - 70 52.2 38.5 49.9 46.3 35.9 50.0718935847885 -0.471258722079155 0.334241617811378 -1.40993430191299 0.158559082939882 0.708520877886452 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3161c - 125.9 104 77.9 98.1 103.1 45.9 172.316273260136 -0.522535122525363 0.257080154716417 -2.03257666116533 0.0420953114160081 0.415841540630995 Possible dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3162c - 15.7 3.9 1.2 16.5 7.1 6.5 4.26004325108664 0.5037660078836 1.13086467041203 0.445469755191888 0.655980312060806 NA Possible integral membrane protein III.A.2 - Cations Rv3163c - 18.1 14.6 6.7 15.5 12.1 13.4 26.853342997305 -0.105885344662623 0.438791508733448 -0.241311289200324 0.809313861876031 0.965980858268586 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv3164c moxR3 32.1 29 18.3 20.5 29.6 19.7 38.7624472068553 -0.40700255747071 0.387199149279059 -1.05114527815602 0.293191871355624 0.835029562814927 Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 I.J.1 - Repressors/activators Rv3165c - 20.4 9 5.9 17.3 11.4 1.4 7.4858339876165 -0.254579247059431 0.817242663441161 -0.31150998160996 0.755412955892866 NA hypothetical protein VI - Unknowns Rv3166c - 19.9 7.4 6.8 13.6 10.6 5.9 15.1653341666358 -0.276507612237063 0.569540119303718 -0.485492773669926 0.627326837464313 NA hypothetical protein V - Conserved hypotheticals Rv3167c - 2.5 8.3 1.7 3.1 2.9 5.1 3.37326798073344 -0.813068639912407 1.23545438691225 -0.658113038025219 0.510465498564173 NA Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3168 - 5.4 4.9 2.4 4.9 1.3 7.2 7.38776011317109 -0.225351477188847 0.812238724535348 -0.277444882128419 0.781438522745262 NA Putative aminoglycoside phosphotransferase V - Conserved hypotheticals Rv3169 - 12.6 13.5 5.7 16.3 21.7 5 21.575390073917 0.319081808494472 0.512171983220978 0.622997389446826 0.533286237344373 NA hypothetical protein V - Conserved hypotheticals Rv3170 aofH 22.8 16.8 7.6 27.9 25.4 14.7 38.9316789781864 0.420017816071348 0.381605545512224 1.10065962355857 0.271044825298875 0.812783093966197 Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3171c hpx 126.7 47.3 52.8 84.7 64.7 34 95.1065903863687 -0.428479241218113 0.303575159849383 -1.41144368146162 0.158113830689605 0.708520877886452 Possible non-heme haloperoxidase Hpx III.F - Detoxification Rv3172c - 126.3 86.8 76.5 103.5 119.1 79.3 76.1064517300168 -0.143686960224849 0.28974218049841 -0.495913159684521 0.619955681118961 0.931582271037618 Hypothetical protein VI - Unknowns Rv3173c - 811.7 461.4 354.1 611.7 793.1 637.9 584.076971034708 0.187514521549518 0.197473963898292 0.949565795145004 0.342332925471632 0.855368447926409 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv3174 - 2.6 2 0 2.9 5 8 3.46058350509567 1.63295503678829 1.20152572685906 1.35906789200182 0.174125076074471 NA Probable short-chain dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3175 - 2.4 0 1.8 1.3 1.2 0 2.42931629797938 -1.01599213360528 1.42084740660497 -0.715060694682854 0.474571539919072 NA Possible amidase (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3176c mesT 33.4 39.3 17 30.1 17.1 23.8 41.5570105412046 -0.513526056049891 0.402589060886031 -1.27555889104316 0.202111493818951 0.761635411312287 Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) II.B.5 - Esterases and lipases Rv3177 - 2.1 2 2.5 1.3 0 6.6 3.19456805498776 -0.0559591215636047 1.29242787837871 -0.0432976744774361 0.965464244983895 NA Possible peroxidase (non-haem peroxidase) III.F - Detoxification Rv3178 - 0.3 0 1.2 0 0 0 0 NA NA NA NA NA hypothetical protein V - Conserved hypotheticals Rv3179 - 5.3 3.4 2.9 8.6 5.1 7.7 10.2889148755719 0.679273561059828 0.663280932717669 1.02411139466445 0.305782662970793 NA hypothetical protein V - Conserved hypotheticals Rv3180c - 13.8 13.6 11 11.1 20.8 2.7 7.84904956673382 -0.375655760292593 0.797907856570097 -0.470800929204275 0.637782900924939 NA Hypothetical alanine rich protein VI - Unknowns Rv3181c - 27.3 20.9 2.9 32 27.9 5 12.5834662435538 0.27467673431711 0.685988489552452 0.400410121307301 0.688854470700841 NA hypothetical protein V - Conserved hypotheticals Rv3182 - 199.1 140.6 87.7 115.2 150.6 147.7 77.4353750896017 -0.235256906310215 0.305177113638745 -0.770886464929024 0.440774230480425 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv3183 - 18.9 10 5.6 14.1 5.2 8.6 4.55167138667102 -0.48621491094721 1.0039865453303 -0.484284289673675 0.628184123917754 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3184 - 9 17.1 6.4 17.1 11.1 8.7 5.51727554045908 0.0123274803212738 0.918703102374602 0.0134183505959766 0.989294026501221 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3185 - 6.5 8.3 2.4 3.8 4.8 0 6.27180928935918 -0.963435270808452 0.894414378242503 -1.07716880927336 0.281404856984617 NA Probable transposase IV.B.1.a - IS6110 Rv3186 - 16.3 11 6.9 20.5 14.6 0 5.37666174313445 0.075357232953062 0.926982502146977 0.0812930479038469 0.935208902661838 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3187 - 5.7 8 5.3 2.4 2.2 5.7 8.10409863060499 -1.25747744843788 0.819595046702272 -1.53426677418009 0.124964036191915 NA Probable transposase IV.B.1.a - IS6110 Rv3188 - 7.5 8.7 7.3 10.5 18.2 0 4.36295862677712 0.1957879005822 1.02559901202229 0.190901022999371 0.848603138675926 NA hypothetical protein V - Conserved hypotheticals Rv3189 - 9.4 12.4 5.9 6.9 7.7 18.2 9.76897533622826 -0.0461276451104502 0.737115236168327 -0.0625786075868285 0.950102064695467 NA hypothetical protein V - Conserved hypotheticals Rv3190c - 33.4 30 11.9 32.2 37.5 30.2 57.7544827851457 0.259157499147925 0.33795303916095 0.766844706564398 0.44317385208617 0.901158530199572 Hypothetical protein VI - Unknowns Rv3190A - 502.1 423.6 245.7 338.1 485.3 613.7 148.687650101809 0.120901481471333 0.302722504204539 0.399380554111843 0.689612820127168 0.942913432418385 hypothetical protein ? Rv3191c - 0.5 7 5.2 1.5 1.8 0 5.08751780921214 -2.56058001751171 1.28970825998619 -1.98539475705856 0.0471005688394327 NA Probable transposase IV.B.1.c - Others Rv3192 - 2.9 3.7 0 0.5 4 0 0.849210801861245 -1.07477147643386 2.30683444030219 -0.465907504091653 0.6412817095674 NA Conserved hypothetical alanine and proline-rich protein VI - Unknowns Rv3193c - 172 107.8 107.7 106.6 145.7 111.3 608.296270697689 -0.290555296826212 0.210112371240302 -1.38285668335973 0.166708814445493 0.725041090026968 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3194c - 32.9 9.9 12.4 23.2 31.1 20.7 33.3822044052055 0.268772754469722 0.419115366437748 0.641285851087121 0.521336980166094 0.916731142491682 Possible conserved secreted protein V - Conserved hypotheticals Rv3195 - 23.1 11.2 9.8 15.2 20.9 8.9 32.2467494520264 -0.146708245057017 0.408299589719052 -0.359315190980146 0.719359311365667 0.949890877982223 hypothetical protein V - Conserved hypotheticals Rv3196 - 2.4 0.3 2.9 2.7 4.1 0 2.77021351768353 0.0157795368842357 1.30736121056286 0.0120697606420815 0.990369958147672 NA hypothetical protein VI - Unknowns Rv3196A - 29.5 11.3 36.8 59.4 12.4 42.9 10.4246106179912 0.356654145260579 0.740810464066313 0.481437780053622 0.630205390928804 NA hypothetical protein ? Rv3197 - 657.3 443.2 332.7 418.9 541.3 387.1 1003.09031123457 -0.262625969081258 0.185330605074424 -1.41706745615919 0.15646320627213 0.70782226167295 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv3197A whiB7 18.9 7.5 5.5 4.9 13.9 33.1 5.85248843633206 0.322395882836687 0.964679518798515 0.334199987202199 0.738228653650434 NA Probable transcriptional regulatory protein WhiB-like WhiB7 ? Rv3198c uvrD2 44.6 26.2 20.8 33.6 48.8 34.5 115.443222566816 0.165337451984515 0.266014297718259 0.621535960294989 0.5342470416889 0.923128239106977 Probable ATP-dependent DNA helicase II UvrD2 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3198A - 33.4 9.4 13.7 62.5 10.8 47.8 11.2792248206921 0.972126521206891 0.719719680859937 1.35070159543973 0.176791041015208 NA Possible glutaredoxin protein ? Rv3199c nudC 49.1 15.5 26.8 67.1 27.1 36.8 54.2993113493697 0.353137938757006 0.383991375177215 0.919650704638952 0.357755320742553 0.877159041773689 Probable NADH pyrophosphatase NudC (NAD+ diphosphatase) (NAD+ pyrophosphatase) (NADP pyrophosphatase) V - Conserved hypotheticals Rv3200c - 85 67.6 50 50.7 61.2 61.6 109.65692955201 -0.438033917073649 0.276205984126642 -1.58589582502604 0.112762943058553 0.648445531184945 Possible transmembrane cation transporter II.C.5 - Other membrane proteins Rv3201c - 8.7 3.7 4.1 8.8 2.9 4.3 27.424211025441 -0.171107560413129 0.474300792235094 -0.360757483888657 0.718280748327943 0.949890877982223 Probable ATP-dependent DNA helicase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3202c - 13.4 6 4.8 15.1 6.3 8.9 43.921315374984 0.21818530618505 0.388422467010309 0.561721642582687 0.57430568628277 0.925885039001838 Possible ATP-dependent DNA helicase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3203 lipV 17.6 1.9 8.4 18.6 13.2 18.6 13.1639499364081 0.65449935757193 0.635102764018378 1.03054087409544 0.302756175110676 NA Possible lipase LipV II.B.5 - Esterases and lipases Rv3204 - 30.4 1.8 8.2 23.9 54.6 7.6 8.75417480147368 1.02021436887183 0.862908714925629 1.18229698139016 0.237087882912577 NA Possible DNA-methyltransferase (modification methylase) IV.H - Miscellaneous transferases Rv3205c - 203 115 107.7 196.7 161.4 101.9 204.932102733461 -0.0624221767486589 0.226943495894719 -0.275056028825859 0.783273192934071 0.963989543249515 hypothetical protein VI - Unknowns Rv3206c moeB1 177.4 85.5 78.2 148.6 135.8 117.1 229.366929124866 0.0836505001840382 0.210801617024697 0.396820960696132 0.691499492701862 0.942913432418385 Probable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) I.G.4 - Molybdopterin Rv3207c - 400.2 319.5 222 353.7 384.4 315.2 460.675066092051 -0.0281207298816198 0.196434782480213 -0.143155552833177 0.886167331885973 0.982420376752145 hypothetical protein VI - Unknowns Rv3208 - 165 112.7 82.8 133.6 112.9 150.9 139.745288132552 -0.0322021918808258 0.256046363374401 -0.125767034752759 0.899916336984715 0.98854987613174 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3208A TB9.4 81.4 36.9 32.5 69.9 45.9 70.9 23.4796522065306 0.155852843670561 0.466267771560811 0.334256093121879 0.73818631942872 NA Conserved protein TB9.4 ? Rv3209 - 182.4 79.9 70.2 79.3 126.8 105.8 94.6022584112808 -0.261712280998558 0.30405319896377 -0.860745033732542 0.389378484301059 0.893826103932853 Conserved hypothetical threonine and proline rich protein V - Conserved hypotheticals Rv3210c - 64.5 32.6 27.7 56.2 55.4 43.7 50.0255668976086 0.13275170991661 0.330984096951779 0.401081837886461 0.688359872134802 0.942913432418385 hypothetical protein VI - Unknowns Rv3211 rhlE 665.5 440.3 367 403.8 478.4 466.6 1213.47649274256 -0.296304759115737 0.194865942788337 -1.52055692685911 0.128371062850629 0.671582561030228 Probable ATP-dependent RNA helicase RhlE II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3212 - 531.3 300.4 216.2 465.4 330.1 258.2 672.286655163177 -0.138462539609517 0.193759457938742 -0.714610481896025 0.474849765997431 0.905192593210816 Conserved alanine valine rich protein VI - Unknowns Rv3213c - 611.5 373.5 223.9 408.5 475 434.7 533.323812426592 0.00265041910029865 0.207564419736365 0.0127691398345875 0.989811977333101 0.999120249206713 Possible SOJ/para-related protein III.C - Cell division Rv3214 gpm2 79.3 45.5 39.3 64.5 66.7 78.2 60.3963799803842 0.160830753328624 0.321446667018325 0.500334176180633 0.616839793421017 0.931582271037618 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) I.G.14 - Iron utilisation Rv3215 entC 33.8 17.4 23.8 31.3 31.2 33.4 51.3569344154313 0.136897872678475 0.348465601645932 0.392859071402903 0.69442357235274 0.943825877173016 Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis) I.G.14 - Iron utilisation Rv3217c - 92.4 77.8 51.4 78.4 74.7 36.2 47.2909282887 -0.367875319536039 0.354621563049173 -1.03737436712225 0.299561419581823 0.84163380028938 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3218 - 7 3.6 2.1 10.2 16.5 3.7 10.0257441000362 1.11231584494635 0.70165050107863 1.58528475820428 0.112901650461853 NA hypothetical protein V - Conserved hypotheticals Rv3219 whiB1 5251.2 3617.7 2887.9 6602.8 4794.6 5129.8 1920.10934145025 0.307371447751423 0.177510374434478 1.73156892227096 0.0833503435292218 0.562041621739757 Transcriptional regulatory protein WhiB-like WhiB1 Contains [4FE-4S]2+ cluster I.J.1 - Repressors/activators Rv3220c - 264 172.1 116 297.2 217.8 165.6 485.227269780467 0.138900926296945 0.197785421811006 0.702280911429723 0.482503995106849 0.907435018449577 Probable two component sensor kinase I.J.2 - Two component systems Rv3221c TB7.3 365.9 236.5 158.9 396.3 242.7 298.1 96.0957682979717 0.148258938373952 0.277192398060887 0.534859323022942 0.592747137934178 0.928941202821899 Biotinylated protein TB7.3 I.H.1 - Synthesis of fatty and mycolic acids Rv3221A rshA 157.1 84.5 72.5 201 118.2 81 56.041658972093 0.206248949836359 0.344868028355077 0.598051813675245 0.549805361041111 0.92521033104044 Anti-sigma factor RshA ? Rv3222c - 188.5 84.4 94.4 156.3 126.8 113.6 110.867310746728 -0.0672689198530545 0.259701161829176 -0.259024331578856 0.795616467110102 0.965360560531176 hypothetical protein V - Conserved hypotheticals Rv3223c sigH 187.8 152.3 123.8 178.4 191 148.6 172.591285903936 -0.0521263677330807 0.236691243011774 -0.22022938858996 0.825692509654553 0.967727711626973 Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3224 - 234.3 178.6 80.4 205 253.2 177.5 250.845774977481 0.228533935092448 0.242184589301833 0.94363533101451 0.345356031110326 0.858763247037453 Possible iron-regulated short-chain dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3224A - 177.7 59.6 45.5 199.3 133.4 112.8 33.6480403335578 0.54930030030571 0.429318458655107 1.27947049382983 0.200731423621669 0.759539148751759 hypothetical protein ? Rv3224B - 138.1 67.7 40 225.8 111.9 46.1 33.4753616420507 0.551333022527262 0.472324605978554 1.16727567344288 0.243099059412352 0.78958848015113 hypothetical protein ? Rv3225c - 57.6 28.9 33.3 59.4 47.7 48.5 103.659680595223 0.194603147090483 0.265685428696955 0.732456981344094 0.463889690465464 0.901158530199572 GCN5-related N-acetyltransferase, phosphorylase IV.D - Antibiotic production and resistance Rv3226c - 35.4 21.8 14.9 29.9 20.9 17.8 27.8908776201653 -0.192217728136058 0.423395771095673 -0.453990666082075 0.649835544909424 0.939577115195416 hypothetical protein V - Conserved hypotheticals Rv3227 aroA 30.8 27 20.5 29.9 37 19.1 59.7112457505314 -0.0621115775809679 0.330619198129055 -0.187864400895205 0.850982949785527 0.975474031954732 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) I.D.4 - Aromatic amino acid family Rv3228 - 27 19.8 16.9 36.4 34.5 23.9 41.5372246522262 0.385336808471089 0.358781283226936 1.07401591578387 0.282815548254363 0.825259204787765 hypothetical protein V - Conserved hypotheticals Rv3229c desA3 868.1 369 571.6 263.3 405.6 331.4 995.959534130342 -1.03769728285214 0.255669581787121 -4.0587436158759 4.93374453768156e-05 0.00413537496703855 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) I.H.2 - Modification of fatty and mycolic acids Rv3230c - 105.1 44.8 41.8 57.3 71.6 65.7 115.630313198177 -0.135943378322019 0.274145872250943 -0.495879719821504 0.619979275313784 0.931582271037618 Hypothetical oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3231c - 32.9 17 19.1 47.2 33.3 46.8 26.3174952504036 0.694794653733025 0.441993867743043 1.57195541485872 0.115960891552228 NA hypothetical protein VI - Unknowns Rv3232c ppk2 70.9 53.1 42.3 49.3 66.8 48 79.0860350179603 -0.227018922441695 0.296197787412808 -0.766443680841208 0.443412350475645 0.901158530199572 Polyphosphate kinase Ppk2 (polyphosphoric acid kinase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3233c - 69.5 77.6 37.4 42.2 60.6 76.2 58.9319571711744 -0.26196828158699 0.378886821028818 -0.691415660422418 0.48930436540341 0.910063990546522 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3234c tgs3 87.4 82.7 53.3 71.9 61 67.2 94.2514477740634 -0.362346187557399 0.287824523992564 -1.25891353012977 0.208061566227048 0.770341510876847 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3 V - Conserved hypotheticals Rv3235 - 7.3 6.7 2.5 1.4 16.7 1.7 5.33838004744052 -0.122124518370754 1.0740319419588 -0.113706598099891 0.909470381921564 NA Hypothetical alanine arginine proline rich protein VI - Unknowns Rv3236c - 94.2 52 34.1 84.3 61.9 59.7 115.88781797072 0.0566922892748488 0.258993245309351 0.218894856532391 0.826731953208438 0.967727711626973 Probable conserved integral membrane transport protein III.A.2 - Cations Rv3237c - 77.9 41.1 46.2 84.7 41.6 70.1 46.1629762073435 0.0612610911611037 0.367261755664726 0.166804983683161 0.867523497217648 0.977876220223739 hypothetical protein III.A.2 - Cations Rv3238c - 43.5 11.8 10.6 35.1 46 27 31.3832878161469 0.555461080950693 0.447884768773556 1.24018747605933 0.214906059583689 0.773070552038584 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3239c - 14.2 10.4 6.2 16.1 13.4 11.1 58.5240211913213 0.258520056949029 0.313619521129956 0.824311114364292 0.409762805004941 0.901158530199572 Probable conserved transmembrane transport protein II.C.5 - Other membrane proteins Rv3240c secA1 119.3 69.6 60.6 104.5 90.7 105 418.36540164442 0.107131083164955 0.201321536065472 0.53213921003521 0.594629582272256 0.929194918847511 Probable preprotein translocase SecA1 1 subunit III.D - Protein and peptide secretion Rv3241c - 190.8 148 87.6 138.7 171.3 130 148.859215755807 -0.12802510350659 0.247187663903821 -0.517926750407756 0.604509377190606 0.93157071158313 hypothetical protein II.A.1 - Ribosomal protein synthesis and modification Rv3242c - 26.4 19.5 7.3 19.2 23.2 5.5 16.3840507621719 -0.246152853605562 0.563757763522032 -0.436628760671501 0.662380601234614 NA hypothetical protein V - Conserved hypotheticals Rv3243c - 56.2 21.9 12.4 42 39.6 28.6 42.1194632209719 0.194322569345977 0.391724122713669 0.496069958622429 0.619845053567452 0.931582271037618 hypothetical protein VI - Unknowns Rv3244c lpqB 164.8 92.8 68.1 148.1 123.5 126 332.804699386255 0.145120849542379 0.198183665368595 0.732254342316628 0.464013341386815 0.901158530199572 Probable conserved lipoprotein LpqB II.C.1 - Lipoproteins(lppA-lpr0) Rv3245c mtrB 195.1 96.1 92 200.3 162.2 131.7 391.146845335158 0.21101067861644 0.194057261080322 1.08736296411553 0.276876432126164 0.819080439851304 Two component sensory transduction histidine kinase MtrB I.J.2 - Two component systems Rv3246c mtrA 617 374.2 245.5 644.6 658 551.6 555.134597864925 0.446494321347192 0.184287635432291 2.4228121452632 0.0154008883662224 0.27042333557534 Two component sensory transduction transcriptional regulatory protein MtrA I.J.2 - Two component systems Rv3247c tmk 148.5 79.4 64.3 123.2 123.2 76 102.767112453913 -0.0169950461201443 0.261432407124595 -0.065007419344323 0.948168092969726 0.998153412295216 Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3248c sahH 751.3 682.6 345.7 464.7 678.2 537.5 1391.74129666359 -0.250050505707338 0.230588531378087 -1.08440131091056 0.27818690275606 0.82002193939739 Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) I.C.5 - Sulphur metabolism Rv3249c - 532 472.4 204.6 283.9 453.2 291.2 381.089270843385 -0.390780980686827 0.260427037764689 -1.50053920683889 0.133474785467275 0.680441181456551 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3250c rubB 635.7 467.3 168.9 532 405.8 318.2 119.644767645535 -0.120761860610773 0.294268929685808 -0.410379243026814 0.681527770403021 0.942913432418385 Probable rubredoxin RubB I.B.6.c - Electron transport Rv3251c rubA 1005.5 953.3 482.3 730.5 1081.4 890.9 232.809597256863 -0.0282511439290319 0.26306402520365 -0.107392654343981 0.914477481789976 0.9932884147079 Probable rubredoxin RubA I.B.6.c - Electron transport Rv3252c alkB 699.2 528.9 289 326.2 503.9 343.4 902.535581016427 -0.523753089837411 0.223392059108218 -2.34454658741333 0.0190502304210313 0.288108079878605 Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (fatty acid omega-hydroxylase) (alkane hydroxylase-rubredoxin) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3253c - 16.1 9.2 5 13.2 16.9 5 24.2085629133488 0.0797319359104992 0.474525388482049 0.168024594354271 0.866563930644622 NA Possible cationic amino acid transport integral membrane protein III.A.1 - Amino acids Rv3254 - 46.4 33.7 19.4 41.1 51.1 42.8 85.8993533200692 0.285090716602723 0.288130186041686 0.989451055161146 0.32244250557323 0.851026689327819 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3255c manA 121.1 86.3 60.2 114.3 64.9 48.7 161.029391849804 -0.392077213923047 0.265824669180044 -1.47494668245968 0.140226878375618 0.682617454377878 Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase) I.A.1 - Carbon compounds Rv3256c - 94.2 48 42.7 118.8 60.1 46.1 110.062156323019 0.138405092811001 0.300032195042135 0.461300804040594 0.64458280817331 0.939577115195416 hypothetical protein VI - Unknowns Rv3257c pmmA 305.2 224.5 149.9 282 236.9 252 542.453369150548 0.0143765099984426 0.192609658143225 0.074640649576109 0.94050063062862 0.998153412295216 Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase) I.A.1 - Carbon compounds Rv3258c - 154.8 72.7 56.3 185 117.4 45.5 78.3609413203116 0.178638868124924 0.348905478158603 0.511997888562013 0.608652487295555 0.931582271037618 hypothetical protein VI - Unknowns Rv3259 - 10.3 17 0.5 8.2 26.4 21.7 8.78971110835049 1.04751914416318 0.845354716804021 1.23914745294551 0.215290896317757 NA hypothetical protein VI - Unknowns Rv3260c whiB2 294.9 127.3 96 360.5 284.9 234.7 96.0208234561507 0.63677355179782 0.282314898062322 2.25554356560116 0.0240992309540939 0.325163282044018 Probable transcriptional regulatory protein WhiB-like WhiB2 I.J.1 - Repressors/activators Rv3261 fbiA 77.8 46.7 40.1 69.1 72.4 50.4 93.8629043947838 0.0394641576977449 0.263782683935827 0.149608598672632 0.88107342378412 0.980703859230131 Probable F420 biosynthesis protein FbiA V - Conserved hypotheticals Rv3262 fbiB 121.4 61.3 89.3 104.1 88.1 84.2 200.354970453769 -0.196182314877538 0.252247069610114 -0.777738727275476 0.436723056410174 0.901158530199572 Probable F420 biosynthesis protein FbiB V - Conserved hypotheticals Rv3263 - 21.7 13.5 6.5 16.2 20.5 9.7 36.778870452446 0.0208695455896937 0.395890348947649 0.0527154694353344 0.95795861333665 0.998153412295216 Probable DNA methylase (modification methylase) (methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3264c manB 248.1 118.3 90.9 206.6 168.3 107.2 261.213758710551 -0.049603970649132 0.226410364437277 -0.219088780553038 0.826580890298256 0.967727711626973 D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate guanylyltransferase) I.C.3 - Sugar nucleotides Rv3265c wbbL1 143.3 102.7 75.1 110.3 84.1 67.6 141.376323672782 -0.453346188005615 0.241405503635741 -1.87794470787905 0.0603887294564573 0.504895079458099 dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase WbbL1 (alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P- decaprenyl) I.C.3 - Sugar nucleotides Rv3266c rmlD 145.5 70.6 43.5 108 102.3 63.3 124.473317214596 -0.0295080876997773 0.269514122989308 -0.109486239060459 0.91281683579185 0.9932884147079 dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase) I.C.3 - Sugar nucleotides Rv3267 - 206.6 101.6 112.2 153.8 197.6 163.6 373.333473357257 0.119220110259226 0.218053322835459 0.546747505192519 0.584552212393251 0.928941202821899 Conserved protein (CPSA-related protein) V - Conserved hypotheticals Rv3268 - 243.2 118 100.3 210.9 181.1 110.1 171.640706940435 -0.0207435867526698 0.239013106877506 -0.0867884904876823 0.930839636362634 0.998010361628995 hypothetical protein VI - Unknowns Rv3269 - 1398.4 712.8 733.7 950.5 861.5 633.5 397.525496707377 -0.390479590892988 0.194619347314183 -2.00637601698777 0.0448161451305559 0.425984389797655 hypothetical protein III.B - Chaperones/Heat shock Rv3270 ctpC 626.2 157.7 270.4 259.7 189.8 106.5 902.627468819625 -1.05429428069489 0.286091943076891 -3.6851589365155 0.000228559966219609 0.0150523063467485 Probable metal cation-transporting P-type ATPase C CtpC III.A.2 - Cations Rv3271c - 93 57.1 33.4 137.7 55.3 68.8 76.1713260897382 0.411988874076033 0.339149739076041 1.21476983941792 0.22445388714228 0.776049314794434 Probable conserved integral membrane protein VI - Unknowns Rv3272 - 197.2 123.6 116.5 125.7 117.6 72.2 240.803683882787 -0.664048155699007 0.218171600846533 -3.04369658160098 0.00233690705084816 0.0818213278815949 hypothetical protein V - Conserved hypotheticals Rv3273 - 179.9 96.5 108 152 130.1 113.3 480.315335989903 -0.151572294120703 0.196177967099554 -0.772626489924757 0.439743462594698 0.901158530199572 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3274c fadE25 102.7 58.4 36.5 127.5 76.1 94.1 149.977525181619 0.463670549663408 0.258946965371302 1.79060043819612 0.0733574366819255 0.54162997700187 Probable acyl-CoA dehydrogenase FadE25 I.A.3 - Fatty acids Rv3275c purE 81.7 55.5 52.9 88.1 64.6 68.4 57.9487258721095 0.027210455041114 0.322005009474943 0.0845032041131379 0.9326563554414 0.998010361628995 Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AIRC) I.F.1 - Purine ribonucleotide biosynthesis Rv3276c purK 50.1 26.7 23.9 60.5 43.5 44.6 83.4888324404632 0.398858751621494 0.279467511802656 1.4272097284179 0.153519451194749 0.703772013967798 Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AIRC) I.F.1 - Purine ribonucleotide biosynthesis Rv3277 - 162.2 104.8 76.4 148.4 148 119.3 163.95921409097 0.111987860871357 0.222417831893825 0.503502169398072 0.614611255473739 0.931582271037618 Probable conserved transmembrane protein V - Conserved hypotheticals Rv3278c - 12.2 1.7 6.6 11.5 2.9 5.5 4.64867358685638 -0.207455296656246 1.06102593464713 -0.195523304267996 0.844983295567866 NA Probable conserved transmembrane protein V - Conserved hypotheticals Rv3279c birA 17.8 21.2 8.7 24.2 20.3 10.6 21.3393916336472 0.121236351154264 0.499433669532573 0.242747653092212 0.808200889470506 NA Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligase) I.G.1 - Biotin Rv3280 accD5 174.6 133.5 109.3 146.8 179.2 166.7 406.78342266799 0.0405580574973397 0.217447674103777 0.1865187000252 0.85203801566137 0.975712312098852 Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) I.H.1 - Synthesis of fatty and mycolic acids Rv3281 accE5 226.4 216.7 209.1 367.3 291.6 286.1 232.321017498913 0.279349721924198 0.25748390909491 1.08492108460738 0.277956608650746 0.82002193939739 Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (epsilon chain) AccE5 V - Conserved hypotheticals Rv3282 - 144 109.5 102.5 181.2 174.9 125.3 149.969293100291 0.227733195321439 0.24592925220652 0.926011010394967 0.354440258324308 0.873002452827281 hypothetical protein V - Conserved hypotheticals Rv3283 sseA 480.5 288 258.7 348.4 448.6 294.3 504.953966273834 -0.0966191005693592 0.196557899100264 -0.491555419607297 0.623033665209623 0.931582271037618 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.C.5 - Sulphur metabolism Rv3284 - 450.9 269.9 235.1 346.4 290 270.7 214.643951295962 -0.248654527886424 0.209985875608741 -1.18414882508447 0.236354155565055 0.78958848015113 hypothetical protein V - Conserved hypotheticals Rv3285 accA3 573.8 257.4 271.3 405 356 283.6 1020.77396491278 -0.229129728137859 0.182873134985272 -1.25294362212532 0.210226224977951 0.770341510876847 Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.H.1 - Synthesis of fatty and mycolic acids Rv3286c sigF 93.1 47.2 55.5 52.5 61.8 85.2 83.9389210489112 -0.185690395091539 0.323208920549796 -0.574521256330641 0.56561512064141 0.92521033104044 Alternative RNA polymerase sigma factor SigF II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3287c rsbW 128.5 73.5 91.7 75.2 57.2 77.7 60.9084189861385 -0.716395935416252 0.336405815439279 -2.1295587131298 0.033208062723037 0.383527707954728 Anti-sigma factor RsbW (sigma negative effector) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3288c usfY 249.5 62.4 139.1 79.6 106.4 90.3 80.6863557251036 -0.907911082384868 0.356117187935187 -2.54947279475347 0.0107885928159061 0.216240925570988 Putative protein UsfY V - Conserved hypotheticals Rv3289c - 393.5 80.7 184.7 87.8 99.9 95.4 94.1059726439864 -1.36840248475082 0.362611851627694 -3.77373899559082 0.000160819010708403 0.0111206345904861 Possible transmembrane protein VI - Unknowns Rv3290c lat 1201.2 417.8 756.4 395.9 432.4 417.4 1341.27498824232 -1.10031369548687 0.254286747867616 -4.327058742596 1.51113670807702e-05 0.00144131177053139 Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) IV.D - Antibiotic production and resistance Rv3291c lrpA 37.9 27.8 12.6 26 38.3 21.7 18.5939984281585 -0.0560729697275687 0.517264748067304 -0.108402843876523 0.913676145343918 NA Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) I.J.1 - Repressors/activators Rv3292 - 35.5 16.5 22 17.2 12.1 8.6 37.2450820459297 -1.1290018181436 0.403600132341152 -2.79732767081773 0.00515272466571689 0.140727431742496 hypothetical protein V - Conserved hypotheticals Rv3293 pcd 65.9 28.2 33.2 35.5 26 27.8 85.4063528941084 -0.681183334621634 0.291558439585908 -2.33635265571149 0.0194728692918609 0.29134901840291 Probable piperideine-6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3294c - 1.1 0 1.3 0 2.3 0 0.685299649072002 -0.638031861730108 2.4867546342025 -0.25657210122571 0.797509114173648 NA hypothetical protein ? Rv3295 - 610.6 458.4 277.1 552 578.9 443.2 515.642953396682 0.0583211012580059 0.191285001961923 0.304891134484319 0.760449068155468 0.959593750764785 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3296 lhr 51 44.8 22.1 43.2 42.7 23 273.244995019308 -0.288202908676544 0.243196403665487 -1.18506237893618 0.235992784334201 0.78958848015113 Probable ATP-dependent helicase Lhr (large helicase-related protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3297 nei 38.9 30 17.6 30.4 36.5 43.5 40.1856432183515 0.142095149865533 0.38272839107583 0.37126890290556 0.710437257270867 0.949890877982223 Probable endonuclease VIII Nei II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3298c lpqC 25.6 25 13.8 29.2 21.6 29.3 34.9884218537272 0.12180693944655 0.401482343145172 0.303393017217961 0.761590366513984 0.959593750764785 Possible esterase lipoprotein LpqC II.C.1 - Lipoproteins(lppA-lpr0) Rv3299c atsB 70.4 47.6 40.5 71.7 67.3 49.8 269.615051702601 0.0604296918382763 0.202384498509834 0.29858853955329 0.765254010872035 0.959593750764785 Probable arylsulfatase AtsB (aryl-sulfate sulphohydrolase) (sulfatase) I.C.5 - Sulphur metabolism Rv3300c - 56.1 30.8 24.4 61.9 52.1 30.6 60.2987005988728 0.241484946484368 0.317306611855276 0.761046059117449 0.446629557062194 0.901158530199572 hypothetical protein I.G.9 - Riboflavin Rv3301c phoY1 138.1 94.1 79.8 120 96.5 124.1 117.122763646329 -0.0639534256383467 0.261838800481741 -0.244247321331608 0.807039279491291 0.965592404376002 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 III.A.4 - Anions Rv3302c glpD2 56.1 39.7 26.5 65.2 57.4 46.4 134.802587122242 0.313360608043727 0.237155823941489 1.3213279051542 0.186392053336213 0.739746500217031 Probable glycerol-3-phosphate dehydrogenase GlpD2 I.B.6.a - aerobic Rv3303c lpdA 45.1 34.5 23.2 38.5 41.1 30.8 83.6849154724663 -0.0824188347386345 0.278217673383589 -0.29623867433109 0.767047815733933 0.960459148175671 NAD(P)H quinone reductase LpdA I.B.2 - Pyruvate dehydrogenase Rv3304 - 30.5 7.2 14 24.8 3.9 26.5 12.8711447927279 -0.12293365163299 0.694007107761509 -0.177136012381066 0.859401555386091 NA hypothetical protein V - Conserved hypotheticals Rv3305c amiA1 70.8 26.6 30.9 53.8 39.4 52.7 84.079806974741 0.0200443885526382 0.302518674069893 0.0662583512051466 0.947172141246417 0.998153412295216 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) II.B.3 - Proteins, peptides and glycopeptides Rv3306c amiB1 127.1 43.8 63.1 112.4 116.9 73.6 165.512919184307 0.206443288280586 0.260519286796737 0.792429961017273 0.42811001536461 0.901158530199572 Probable amidohydrolase AmiB1 (aminohydrolase) II.B.3 - Proteins, peptides and glycopeptides Rv3307 deoD 159.5 79.3 82.4 132.4 91.8 66.8 129.669274325919 -0.306094869402718 0.261533737165704 -1.17038387750633 0.241846520826511 0.78958848015113 Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) I.F.4 - Salvage of nucleosides and nucleotides Rv3308 pmmB 32.9 16 17.7 46.8 27.2 25.7 69.2157919694077 0.426184443846831 0.316260510939593 1.34757400657028 0.177795435600235 0.734764437650925 Probable phosphomannomutase PmmB (phosphomannose mutase) I.A.1 - Carbon compounds Rv3309c upp 6.9 2.4 4.3 9.9 7.3 5.6 5.62867357904791 0.611811862345686 0.876485218146787 0.698028728469925 0.485159227990622 NA Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv3310 sapM 51.6 43 23.5 38.4 84.8 41.4 66.3579237323563 0.29060522793358 0.3576140309093 0.812622556208609 0.416434495102843 0.901158530199572 Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3311 - 51.6 39.3 18.1 62.4 48.1 78.5 99.0302104291069 0.672042672339611 0.31171279929569 2.15596752477948 0.0310862010669742 0.375387808282729 hypothetical protein V - Conserved hypotheticals Rv3312c - 35.1 18.9 23.8 34.3 39.6 10.5 39.021239564983 -0.0766269094665693 0.411383344209204 -0.186266436269723 0.85223582680173 0.975712312098852 hypothetical protein V - Conserved hypotheticals Rv3312A - 278.1 173.9 187.2 142.5 265 147.5 101.271573995966 -0.432339826556894 0.306568287941895 -1.41025619270457 0.158464048753854 0.708520877886452 Secreted protein antigen ? Rv3313c add 22.1 22.7 9.5 32.5 33 13.9 38.0207211929081 0.420143775776644 0.400785452578038 1.04830096270732 0.294499966237392 0.837161771605085 Probable adenosine deaminase Add (adenosine aminohydrolase) I.F.4 - Salvage of nucleosides and nucleotides Rv3314c deoA 26.3 17.2 9.2 35.7 15.6 28.8 43.9514544103217 0.475092193787785 0.385667071298969 1.23187129299793 0.217997166435916 0.773070552038584 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv3315c cdd 14.7 27.8 1 27 9.4 13.2 9.19486750836681 0.228671042064608 0.843054370021318 0.271241156200667 0.786205560928085 NA Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) I.F.4 - Salvage of nucleosides and nucleotides Rv3316 sdhC 72.8 42.3 24.2 69.3 80.4 63.5 30.0046791680251 0.460476836350756 0.414963378473181 1.10968066156835 0.26713665901765 0.810197367152215 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3317 sdhD 59.8 54.3 27.9 67.4 55.6 86.6 40.449923070423 0.409938625791949 0.389775096379238 1.05173118960143 0.292922896976506 0.835029562814927 Probable succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3318 sdhA 52 20.2 28.3 36.4 40.9 51.8 108.637087339152 0.186669100008259 0.304626186058997 0.612780872265874 0.540021240051113 0.925170967849126 Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3319 sdhB 102 76.7 35.5 86.5 66.4 75.5 92.0343714335204 -0.0347855106712451 0.289891273074162 -0.119995025384383 0.904487088653623 0.991208909356546 Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3320c vapC44 208.8 150.7 93.9 249.3 292.1 207.8 134.950234826695 0.566654118332578 0.245130378523788 2.31164379439649 0.0207973211180153 0.297479746745841 Possible toxin VapC44 Contains PIN domain V - Conserved hypotheticals Rv3321c vapB44 218.2 119.8 78.5 289.4 301.7 169.1 72.7996919207589 0.730877897133072 0.300932566025865 2.42870988269928 0.0151526519585986 0.270401518177314 Possible antitoxin VapB44 V - Conserved hypotheticals Rv3322c - 25.8 5 6.7 23.2 17.2 8.7 12.712481516331 0.251160966315411 0.641155794695976 0.391731570381434 0.695256560797702 NA Possible methyltransferase I.G.4 - Molybdopterin Rv3323c moaX 54.5 18.1 17.3 37.8 34.1 37.8 33.2141230963642 0.125718969575336 0.417055896271199 0.301443932814186 0.763075997758344 0.959593750764785 Probable MoaD-MoaE fusion protein MoaX I.B.4 - Glyoxylate bypass Rv3324c moaC3 13.4 9.7 3.8 12.4 11.3 9.2 7.68485843034471 0.04708374605153 0.756680049880642 0.0622241144839976 0.950384359114926 NA Probable molybdenum cofactor biosynthesis protein C 3 MoaC3 I.G.4 - Molybdopterin Rv3325 - 18.3 0.5 8.9 19.8 5.8 23.9 5.91277340458524 0.523179862851358 0.955502501083667 0.547544210777054 0.584004905583885 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3326 - 5.3 3.5 7.5 2.4 6.3 10.7 9.77715600270546 -0.175164512613743 0.791213228909997 -0.221387239511979 0.824790927336468 NA Probable transposase IV.B.1.a - IS6110 Rv3327 - 5.8 5.8 2 5.1 2 0 8.98386923759386 -0.841316616391024 0.790743147380069 -1.06395688559366 0.287348231282609 NA Probable transposase fusion protein IV.B.1.c - Others Rv3328c sigJ 107.3 43 48.7 86.4 59.9 50.6 96.9557824005156 -0.163465982769528 0.283324844109337 -0.576956049454124 0.563969145865967 0.92521033104044 Probable alternative RNA polymerase sigma factor (fragment) SigJ II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3329 - 47.2 22.6 25.5 36.6 26.1 31 66.3136385946062 -0.194270186761678 0.310350211702295 -0.62597085304402 0.531334059326598 0.922751607774049 Probable aminotransferase IV.H - Miscellaneous transferases Rv3330 dacB1 38.1 20.9 16.5 26.1 36.6 17.5 49.0229968657159 -0.0862858600888761 0.347537939558912 -0.248277526759778 0.80391968578728 0.965592404376002 Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase) II.C.3 - Murein sacculus and peptidoglycan Rv3331 sugI 25.2 17.1 12.2 36.2 28.6 19.7 53.9995917055055 0.505943557897403 0.325775646525684 1.55304290941685 0.120412883744478 0.665646250765128 Probable sugar-transport integral membrane protein SugI III.A.3 - Carbohydrates, organic acids and alcohols Rv3332 nagA 32.2 19.5 13.5 41.8 28.3 22.7 46.6698953088706 0.383640013553197 0.348508684008947 1.10080474649908 0.270981645524469 0.812783093966197 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) II.C.3 - Murein sacculus and peptidoglycan Rv3333c - 8 3.8 1.7 3.5 6.9 0 4.83407978077634 -0.44607555047125 0.987143467577264 -0.45188522755061 0.651351667096998 NA Hypothetical proline rich protein VI - Unknowns Rv3334 - 19.1 15.4 16.4 12.2 29.9 25.4 13.6852091381988 0.0645763641064903 0.624694290013191 0.103372745899641 0.917667141866715 NA Probable transcriptional regulatory protein (probably MerR-family) I.J.1 - Repressors/activators Rv3335c - 100 49.2 40.2 114.1 47.3 66.9 94.1507766976946 0.14818252784226 0.314063192555296 0.471823923830777 0.6370524730993 0.93628434675487 Probable conserved integral membrane protein V - Conserved hypotheticals Rv3336c trpS 323.7 214.1 156.2 270.6 317.9 252.3 412.391852153811 0.109211996784462 0.193701055912755 0.563817250607305 0.572878510470342 0.925885039001838 Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3337 - 64.6 41.1 22.8 39.8 42.5 41 25.0010755034275 -0.243146086875814 0.448121523578462 -0.542589619293842 0.58741238783733 NA hypothetical protein V - Conserved hypotheticals Rv3338 - 74.8 43.7 27.8 52.6 64.9 33.5 49.0611941873842 -0.111938113654728 0.345243040879713 -0.324229891410697 0.745763993306997 0.956095160416489 hypothetical protein V - Conserved hypotheticals Rv3339c icd1 438.4 332.1 223.2 266.2 346.1 347.4 651.599314593664 -0.212849388915192 0.220478962663107 -0.965395456982565 0.334346776079628 0.853347384539607 Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) I.B.3 - TCA cycle Rv3340 metC 45.2 23.5 23.4 30.4 24.3 20.9 59.758330895393 -0.463535356145543 0.314072133984787 -1.47588819888108 0.139973908055921 0.682617454377878 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) I.D.2 - Aspartate family Rv3341 metA 61.7 27.8 36.8 52 35.2 31.6 74.24041427309 -0.261848715195781 0.308619807908341 -0.848450774985737 0.396186975540236 0.893826103932853 Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) I.D.2 - Aspartate family Rv3342 - 72.3 46.9 42.7 54 49 29.9 57.3942805488921 -0.466538556685367 0.322747949646879 -1.44551981568221 0.148311931148896 0.695223866622759 Possible methyltransferase (methylase) V - Conserved hypotheticals Rv3343c PPE54 17.4 21.2 14.5 13.6 21.7 26 242.806641406868 -0.0276512521411747 0.317738160542478 -0.0870252792235136 0.930651418417254 0.998010361628995 PPE family protein PPE54 IV.C.2 - PPE family Rv3344c PE_PGRS49 4.4 1.2 3.6 4.7 3.4 1.7 6.71807642991855 -0.143672782566056 0.846853133204139 -0.169654898745498 0.86528154535634 NA PE-PGRS family protein PE_PGRS49 IV.C.1.b - PE_PGRS subfamily Rv3345c PE_PGRS50 3.1 1.9 2.2 2.7 1.6 2.5 16.8098099050647 -0.33644910956707 0.538566772310984 -0.624711970483011 0.532160115201692 NA PE-PGRS family protein PE_PGRS50 IV.C.1.b - PE_PGRS subfamily Rv3346c - 11.6 0 5.1 12 2.1 0 1.77352848358339 -0.441552233672771 1.69040812809735 -0.261210429797072 0.793930235445265 NA Conserved transmembrane protein V - Conserved hypotheticals Rv3347c PPE55 40.9 24.6 26.2 18.1 29.6 29.7 441.283657065103 -0.431723703267086 0.261130187526356 -1.65328914039673 0.098272032061622 0.61497837258472 PPE family protein PPE55 IV.C.2 - PPE family Rv3348 - 22 12.2 11.3 21.2 15.8 36.6 15.1067339299381 0.505119292508975 0.58112541999755 0.869208737265537 0.384732969304877 NA Probable transposase IV.B.1.c - Others Rv3349c - 1.7 4.7 0.3 2 2.7 0 1.81703505915498 -0.729700013453559 1.63740658612151 -0.445643751306744 0.655854601615819 NA Probable transposase IV.B.1.c - Others Rv3350c PPE56 8.7 5.7 4.3 5.4 7.8 6.6 115.015071935354 -0.106731002374622 0.271901685567625 -0.392535273004317 0.694662754217905 0.943825877173016 PPE family protein PPE56 IV.C.2 - PPE family Rv3351c - 1.6 0 0 1.8 0 1.6 0.543934874476832 0.270980198607679 2.87099588300198 0.0943854361519795 0.924802984422961 NA hypothetical protein V - Conserved hypotheticals Rv3352c - 2.4 5.9 0 2.6 4.6 0 1.2435213623556 -0.587301678814986 1.89674423899442 -0.309636727367286 0.756837223563278 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3353c - 5.1 4.4 0 5.4 0 0 0.87908172209499 -0.413110959122516 2.23891693321803 -0.184513749926731 0.85361044146168 NA hypothetical protein V - Conserved hypotheticals Rv3354 - 6.4 4.4 8.8 6.2 4.7 0 2.89807952075016 -1.0213884886033 1.28585092137483 -0.794328853854405 0.427004010669034 NA hypothetical protein V - Conserved hypotheticals Rv3355c - 30.9 23.8 11.2 32.2 20.4 2.1 8.50571051514853 -0.319992159351934 0.77292790391676 -0.414000009225175 0.678874100076995 NA Probable integral membrane protein V - Conserved hypotheticals Rv3356c folD 57.2 20.4 35.5 49.5 44.8 31.8 52.8752477074916 -0.0407487156133559 0.351386648818932 -0.115965463543703 0.907679913181036 0.992210970746976 Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase I.G.2 - Folic acid Rv3357 relJ 3.7 3.5 0 8.1 9.9 0 1.1608182630385 1.77809689448886 2.001996689289 0.888161755712167 0.374453747487523 NA Antitoxin RelJ V - Conserved hypotheticals Rv3358 relK 5 3 0.7 13.8 11.5 4 1.5255500012103 1.85327644352247 1.82078492743361 1.01784478528975 0.308751724814602 NA Toxin RelK VI - Unknowns Rv3359 - 14.4 7.9 10.4 7.3 6.3 13.1 19.4030613921379 -0.626143905565429 0.537935517341941 -1.16397576545855 0.24443383307411 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3360 - 43.7 18.9 26.3 31.4 33.4 7.8 15.0386792920869 -0.480157860681242 0.590238646181104 -0.813497834795986 0.415932687182818 NA hypothetical protein II.C.5 - Other membrane proteins Rv3361c - 69.1 34.4 38.3 86.2 50.5 50.1 47.2392710886574 0.250037240226048 0.353596170621493 0.707126550003566 0.479487838065912 0.907292899730371 hypothetical protein V - Conserved hypotheticals Rv3362c - 96.3 75.9 54 100.9 111.2 58.4 76.2617222693794 0.0961998965934226 0.294895683955031 0.326216699082284 0.744260407835906 0.956095160416489 Probable ATP/GTP-binding protein VI - Unknowns Rv3363c - 84.6 63.6 52.8 73.4 44 68.7 38.1463435813889 -0.326087788686752 0.386047116893203 -0.844683911412195 0.398287344571383 0.893826103932853 hypothetical protein VI - Unknowns Rv3364c - 78.5 33 72.9 91.4 46 46.9 38.8769716412493 -0.236372665666662 0.434982983753045 -0.543406695193528 0.586849816966138 0.928941202821899 hypothetical protein VI - Unknowns Rv3365c - 105.9 62.7 61.5 86.3 96.3 52.1 325.524261197426 -0.170113825339157 0.214526719626463 -0.792972668557845 0.427793746866277 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv3366 spoU 15.4 8.2 6.9 18.6 17.3 2.7 7.50601731026451 0.194748201937154 0.804159748814705 0.242176013191662 0.808643780613474 NA Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3367 PE_PGRS51 24.4 8.3 5.5 34.2 15.5 9.6 41.9734369422793 0.555371333958143 0.443190806802426 1.25312015825664 0.210161980886698 0.770341510876847 PE-PGRS family protein PE_PGRS51 IV.C.1.b - PE_PGRS subfamily Rv3368c - 16.3 6.2 8.7 11 13.4 24.8 13.1194941146737 0.414681559207886 0.637738795840649 0.650237310184752 0.515538944174433 NA Possible oxidoreductase V - Conserved hypotheticals Rv3369 - 51.4 36.9 17.3 59.5 24.1 58 27.483748693303 0.282703980806357 0.465415709552005 0.607422514978016 0.543570550376269 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv3370c dnaE2 15.6 3.7 6.9 12.2 11.4 5.2 45.1547425510353 0.00900036794367482 0.398570675051286 0.022581611009181 0.981984012376956 0.998667985896356 Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3371 - 201.1 60.8 125.4 43.5 47.8 36.8 189.850901124342 -1.79445307218478 0.304628165324841 -5.89063414497889 3.84716428791703e-09 9.67386947307137e-07 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3372 otsB2 34.6 17.7 17.8 25.4 27.6 18.7 43.9385937719418 -0.147623565056038 0.349259235751219 -0.422676195630206 0.672531525608217 0.940710721884994 Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP) III.E - Adaptations and atypical conditions Rv3373 echA18 20.4 10.8 6.5 27.9 26.1 28.7 19.1459093182611 0.973112432803471 0.507037977361227 1.91921015042666 0.0549577434516713 NA Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3374 echA18.1 18.1 28.2 1.3 36.9 15.8 57.9 9.74315490471539 1.24080239287625 0.807141003450587 1.537280831443 0.1242245534437 NA Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3375 amiD 20.3 12.5 9.9 22.7 17 15.8 36.2552877299661 0.220972315759002 0.375693655546517 0.588171539488885 0.556417158474721 0.92521033104044 Probable amidase AmiD (acylamidase) (acylase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3376 - 534.7 348.4 269.5 345.5 388.4 312.2 386.084990036955 -0.315226352956062 0.192100613471937 -1.6409440202132 0.100809036089998 0.625196847141109 hypothetical protein V - Conserved hypotheticals Rv3377c - 74.8 47.7 31.9 43.2 78 72.7 139.657197950578 0.176624068504821 0.296676929367238 0.595341433799826 0.551615265068549 0.92521033104044 Halimadienyl diphosphate synthase IV.J - Cyclases Rv3378c - 37 23.8 14.9 26.4 33.2 29.4 38.1033083319065 0.0442896636873853 0.377990377597293 0.117171405179449 0.906724226166447 0.992210970746976 Diterpene synthase VI - Unknowns Rv3379c dxs2 4.4 1.1 2 4.8 1.6 3.5 6.76963270863896 0.247317172731418 0.841422818521538 0.293927342220144 0.768813424397796 NA Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) IV.H - Miscellaneous transferases Rv3380c - 4 8.8 1.7 4.2 9.3 6.7 8.51608707327644 0.28736333627271 0.802361729989133 0.358146862608467 0.72023341058023 NA Probable transposase IV.B.1.a - IS6110 Rv3381c - 15.5 29 14.8 31.4 29 40.7 13.7419858405218 0.546893188317882 0.630189974030165 0.867822737357139 0.385491380679013 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3382c lytB1 33.7 36.5 15.6 68 52 37.5 62.1131270435896 0.743394239970403 0.336903412597705 2.20655004423504 0.0273455103164483 0.351916356176503 Probable LYTB-related protein LytB1 II.C.3 - Murein sacculus and peptidoglycan Rv3383c idsB 49.6 57.9 23.6 94.7 87 101.3 115.17234372009 0.962924053354051 0.30150093810347 3.19376801747659 0.00140428914735821 0.0611725004333888 Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3384c vapC46 60.8 31.9 16.5 56.4 70.1 55.3 28.6935244881197 0.53827949579178 0.430872642262541 1.24927749639717 0.211563595772258 0.773070552038584 Possible toxin VapC46 Contains PIN domain V - Conserved hypotheticals Rv3385c vapB46 109.5 81.2 45.9 124.9 82.6 91.6 43.2693144616064 0.193891145410548 0.358138573520243 0.541385820311781 0.588241678667441 0.928941202821899 Possible antitoxin VapB46 V - Conserved hypotheticals Rv3386 - 12.1 7.3 4.6 13 22.6 4 10.8990343820085 0.494158742165479 0.678380336449836 0.728439071143419 0.466344853310317 NA Possible transposase IV.B.1.c - Others Rv3387 - 6.9 3 3 9.2 5.4 4.2 5.01900655124338 0.252638560483417 0.923565091852601 0.273547108603513 0.78443268518528 NA Possible transposase IV.B.1.c - Others Rv3388 PE_PGRS52 7.7 7.8 3.8 11.3 3.2 2.7 20.6517200835305 -0.264580770965859 0.562287941495422 -0.470543206497009 0.637966972886458 NA PE-PGRS family protein PE_PGRS52 IV.C.1.b - PE_PGRS subfamily Rv3389c htdY 95.4 57.8 39.5 124.5 73.8 97.6 111.317417855841 0.487186408805305 0.272397782301965 1.7885109221089 0.073693615112635 0.54162997700187 Probable 3-hydroxyacyl-thioester dehydratase HtdY I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3390 lpqD 98.3 108 63 50.8 119.4 111.3 108.088187358257 -0.159888252739223 0.360805805704133 -0.443142128567448 0.657662934771619 0.939577115195416 Probable conserved lipoprotein LpqD II.C.1 - Lipoproteins(lppA-lpr0) Rv3391 acrA1 37.4 29.2 16.5 16.3 25.7 19.7 76.0372143287055 -0.634778760098051 0.316868924273598 -2.00328499095719 0.0451467075608768 0.426978463692289 Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 I.H.2 - Modification of fatty and mycolic acids Rv3392c cmaA1 49.3 21.7 23.3 26.8 32.1 39.3 44.3714078721813 -0.150914675084764 0.375739899453632 -0.401646658510877 0.687944086341305 0.942913432418385 Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) I.H.2 - Modification of fatty and mycolic acids Rv3393 iunH 28.9 13 9.8 20.9 23.8 9.2 24.4869473887566 -0.0736776686503159 0.459891586162068 -0.160206602745612 0.872718328338387 NA Probable nucleoside hydrolase IunH (purine nucleosidase) I.F.4 - Salvage of nucleosides and nucleotides Rv3394c - 13 9.3 5.4 14.4 9.7 8.9 24.6775536690825 0.107025918284705 0.447936264903355 0.238931130766553 0.811158985686994 NA hypothetical protein VI - Unknowns Rv3395c - 36.7 36.4 31.8 36.4 27 14.9 30.8042031566029 -0.590771939816814 0.441550171652788 -1.33794974556451 0.180912819377681 0.735038480974451 hypothetical protein VI - Unknowns Rv3395A - 4.7 0.5 4.3 2.2 4.1 4.5 2.9421272373538 -0.412261317865041 1.25564935528683 -0.328325193756714 0.742665797163015 NA Probable membrane protein ? Rv3396c guaA 65.4 30 23.9 82.8 52.5 64.3 129.236506842547 0.615227021947988 0.267145274112688 2.30296801615315 0.0212806427074673 0.300317641473747 Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv3397c phyA 17.9 16 6.5 27.7 16.6 17.5 23.9063697746309 0.49257852244413 0.468554972671489 1.05127157147788 0.293133879868621 NA Probable phytoene synthase PhyA I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3398c idsA1 11.5 6.1 5.8 10.9 3.4 10.9 13.2195413687538 -0.103693183574035 0.61513206989363 -0.168570602394322 0.866134405494919 NA Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3399 - 21.1 15.8 6.3 20.5 35 11.7 29.4062844075161 0.49885586799711 0.453913490713434 1.09901088688296 0.271763317247235 0.813286748879977 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv3400 - 91.3 37.1 54.6 77.1 61.5 50.6 77.6851687572661 -0.150220436103222 0.304484477120962 -0.493359916156067 0.621758299587711 0.931582271037618 Probable hydrolase I.C.3 - Sugar nucleotides Rv3401 - 104.8 72.1 74.3 87.9 98.2 85.9 336.863785742832 -0.103434070315582 0.219548957548179 -0.471120753524343 0.637554505503294 0.936524568360123 hypothetical protein V - Conserved hypotheticals Rv3402c - 11.3 8.8 12.2 13.2 17.1 10.9 24.35528570465 0.0839381438071481 0.48099600469043 0.17450902499943 0.861465438668948 NA hypothetical protein II.C.5 - Other membrane proteins Rv3403c - 33.7 17 17.8 46 37.6 38.5 79.9208765076023 0.655657610779301 0.283781060291427 2.31043470662199 0.0208640994830903 0.297479746745841 Hypothetical protein VI - Unknowns Rv3404c - 61.3 58.8 25.6 59.6 57.6 65.9 61.7996250317964 0.159029002393796 0.335570926645937 0.473905781955861 0.635567095899062 0.934597866696866 hypothetical protein VI - Unknowns Rv3405c - 16.9 12.2 10.4 21 22 20 14.8008087023899 0.471013452398808 0.554449638218763 0.84951530298044 0.39559461864526 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3406 - 6.3 4.7 3.8 3.1 10.4 5.7 7.97408639822448 0.103390905475349 0.786525658800134 0.131452679666006 0.895417217817569 NA Probable dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3407 vapB47 5708.3 3730.2 2707.7 4862.2 5663.7 4870.5 2197.93485910736 0.189310070920163 0.174760201581708 1.08325619452695 0.278694723150183 0.820074047056815 Possible antitoxin VapB47 V - Conserved hypotheticals Rv3408 vapC47 2304.5 1538.5 1439.7 1686.3 2167.2 1769.5 1216.189404149 -0.105124620870921 0.196488247520473 -0.535017346826138 0.592637862150718 0.928941202821899 Possible toxin VapC47 Contains PIN domain V - Conserved hypotheticals Rv3409c choD 91 38.2 34.2 83.6 65.7 42.6 157.852760816259 0.0999816360928725 0.254275337141522 0.393202255542485 0.694170103931254 0.943825877173016 Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase) I.A.3 - Fatty acids Rv3410c guaB3 62.8 29.3 32.6 66 29.6 29.2 73.4046715122254 -0.139251891559147 0.335968399783948 -0.414479134492103 0.678523244909953 0.942913432418385 Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv3411c guaB2 212.2 142.2 134.6 205.5 165.6 117.4 417.312511179006 -0.213143194249822 0.204605676291633 -1.04172669161935 0.297538410335063 0.838076622186134 Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv3412 - 912.4 498.7 466.7 424.5 626.5 637.6 396.374839913228 -0.307188587677295 0.243132846417662 -1.26345984182489 0.206423969895355 0.770341510876847 hypothetical protein V - Conserved hypotheticals Rv3413c - 107.5 59.1 37.7 123.6 62.4 52 101.500524601988 0.106411687682861 0.307720533020044 0.34580626336017 0.729488317756119 0.949983374253025 Unknown alanine and proline rich protein VI - Unknowns Rv3414c sigD 259 96.9 80.4 333.9 210.8 219.7 194.329365546052 0.712820233990324 0.262839438914579 2.71199876599184 0.00668788417991387 0.161324912772436 Probable alternative RNA polymerase sigma-D factor SigD II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3415c - 6 6.8 4.2 6.8 17.1 0 8.34517536075119 0.314277140281897 0.804600014382597 0.390600465652558 0.696092581390808 NA hypothetical protein V - Conserved hypotheticals Rv3416 whiB3 348.6 156.4 202.8 107.3 184.7 78.2 89.8493203101466 -1.14950128843464 0.321216975024012 -3.57858201095602 0.000345463467372226 0.0203446601631311 Transcriptional regulatory protein WhiB-like WhiB3 Contains [4FE-4S] cluster I.J.1 - Repressors/activators Rv3417c groEL1 106 74.4 46.3 95.7 90.4 58.5 200.560829183915 -0.0460365471181232 0.222920332381686 -0.206515693863667 0.836388107024177 0.970813891745226 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) III.B - Chaperones/Heat shock Rv3418c groES 829.4 620.2 729.8 506.4 1468.4 725.6 406.167807367324 0.0541119139437896 0.521390031511852 0.103783944213286 0.917340808317083 0.9932884147079 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen) III.B - Chaperones/Heat shock Rv3419c gcp 134.2 78.1 59.9 143.9 98.9 75.4 159.023150361471 0.0725782789691796 0.242112066058214 0.29977142465807 0.764351513299242 0.959593750764785 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) II.B.3 - Proteins, peptides and glycopeptides Rv3420c rimI 299 248 183.3 211.3 217.8 238.3 182.084368758635 -0.340567328405181 0.245189336571672 -1.3889973078239 0.164833568696924 0.724848411789655 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) II.A.1 - Ribosomal protein synthesis and modification Rv3421c - 65.8 15 16.3 59.7 59.6 28.4 38.0050951585255 0.485848119355897 0.433660080604639 1.12034319294157 0.262567542537304 0.806685286411718 hypothetical protein V - Conserved hypotheticals Rv3422c - 106.7 62.6 81 155 119.1 75.7 80.1758693191416 0.279271804628522 0.309879032578492 0.901228464232355 0.367466859700308 0.883373818299354 hypothetical protein V - Conserved hypotheticals Rv3423c alr 112.7 79.9 47.7 94.5 109.8 91.4 173.969448772363 0.143014738229224 0.23408950026899 0.610940422637015 0.541239022741664 0.92521033104044 Alanine racemase Alr I.D.6 - Pyruvate family Rv3424c - 82.7 42.6 28.8 64.3 58.3 44 29.5575392758942 -0.0128292258613545 0.413613564329568 -0.0310174205291105 0.975255646783606 0.998153412295216 Hypothetical protein VI - Unknowns Rv3425 PPE57 78.3 37.6 37.3 46.5 67.8 40.4 42.4422963136514 -0.190170407860724 0.366074791504958 -0.519485122367811 0.603422485122175 0.931398768888358 PPE family protein PPE57 IV.C.2 - PPE family Rv3426 PPE58 32.6 30.1 9.5 15.7 31.4 23.2 25.8400143862813 -0.244724562079135 0.488542828855724 -0.500927549489027 0.616422112943654 NA PPE family protein PPE58 IV.C.2 - PPE family Rv3427c - 48 32.3 39.5 29.8 44.8 46.2 49.9172124209861 -0.270188900962276 0.380509679795776 -0.710071031852038 0.477660088978177 0.907292899730371 Possible transposase IV.B.1.c - Others Rv3428c - 3.3 1.3 2.1 2.7 4.2 0 3.92499234484038 -0.224147718407697 1.07129203876788 -0.209231199613407 0.834267757628635 NA Possible transposase IV.B.1.c - Others Rv3429 PPE59 829 705.2 342.2 364.6 911.8 1041.8 612.234764240489 0.205752623827324 0.566522403754052 0.363185325882803 0.716466448579956 0.949890877982223 PPE family protein PPE59 IV.C.2 - PPE family Rv3430c - 22.4 5 17.6 16.3 15.3 17.7 29.4175652348704 -0.0941330158791482 0.476671894771063 -0.197479685527418 0.843452177019268 0.974922156972543 Possible transposase IV.B.1.c - Others Rv3431c - 29.7 9.2 10.7 29.7 22.5 22.8 26.5974513474674 0.432318780104154 0.44863147876541 0.963638978909491 0.3352269573672 NA Possible transposase (fragment) IV.B.1.c - Others Rv3432c gadB 25.5 18.5 10.5 27.5 24.8 20.5 45.262971377801 0.266444507580475 0.345219531338926 0.771811799138583 0.440225902358143 0.901158530199572 Probable glutamate decarboxylase GadB I.C.1 - General Rv3433c - 25.6 9.8 15.1 31.6 10.4 31.7 46.7405767946783 0.363525692078755 0.423505667520048 0.858372673516928 0.390686711851136 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv3434c - 37.4 30.3 21.8 56 42.7 26.3 39.8777533341961 0.354343174894373 0.373608572031589 0.94843427431963 0.342908417846847 0.856033108090595 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3435c - 58.9 41.1 23 66.2 52.5 40.3 62.5012877569498 0.237440923116324 0.312047076692097 0.760913787859682 0.446708562621595 0.901158530199572 Probable conserved transmembrane protein V - Conserved hypotheticals Rv3436c glmS 38.6 24.1 15.9 49.7 54.3 30.8 102.929872988943 0.630542719098664 0.264953707557591 2.37982221464709 0.0173209925246191 0.276757764055105 Probable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase) I.C.4 - Amino sugars Rv3437 - 44.5 38 21.5 21.1 37.9 29.7 24.293109284016 -0.445590245341737 0.476591820853408 -0.934951515835588 0.349813286435475 NA Possible conserved transmembrane protein VI - Unknowns Rv3438 - 25.3 17.6 5.7 29.1 27.7 11.8 24.2423671642735 0.397658432119153 0.485480281123203 0.819103159450955 0.412727559471893 NA hypothetical protein V - Conserved hypotheticals Rv3439c - 27.7 21.1 18.3 42.3 39.5 14.2 59.3386939197196 0.342142917668092 0.349533804593646 0.978855015370696 0.327651621889985 0.853347384539607 Conserved hypothetical alanine and proline rich protein V - Conserved hypotheticals Rv3440c - 60 41.2 33.3 51.6 33.5 39.7 21.3671555738285 -0.285251921348298 0.47609595300825 -0.599147964913187 0.549074218708456 NA Hypothetical protein VI - Unknowns Rv3441c mrsA 171.4 109.9 82.1 201 155.4 90.1 284.4832412867 0.123492825925627 0.225419557328453 0.547835455757234 0.583804890789158 0.928941202821899 Probable phospho-sugar mutase / MrsA protein homolog I.A.1 - Carbon compounds Rv3442c rpsI 141.8 68 56.1 196.5 141.4 121.3 84.5610621670645 0.645068358175959 0.285010875092397 2.26331138405451 0.0236165010225085 0.321789368612111 30S ribosomal protein S9 RpsI II.A.1 - Ribosomal protein synthesis and modification Rv3443c rplM 264.2 142.5 136.4 201.9 215.3 196.8 136.759748700916 -0.00825430712625103 0.241803267088149 -0.0341364582275968 0.972768335955339 0.998153412295216 50S ribosomal protein L13 RplM II.A.1 - Ribosomal protein synthesis and modification Rv3444c esxT 5.7 0 3.2 17.2 0 0 1.71258275126867 0.990980242591665 1.74247110769708 0.568721190391148 0.569545364908913 NA Putative ESAT-6 like protein EsxT V - Conserved hypotheticals Rv3445c esxU 7.2 0 10.2 16.3 14.5 8.7 4.44449086944983 0.728512375018937 1.03771677803023 0.702033917579883 0.482658011580058 NA ESAT-6 like protein EsxU VI - Unknowns Rv3446c - 1.2 1.4 1.4 1.2 3 2 2.75445449637523 0.472722586830467 1.24737372631943 0.378974301651606 0.704706947260059 NA Hypothetical alanine and valine rich protein VI - Unknowns Rv3447c eccC4 2.2 1.9 0.6 0.9 2 0.1 6.73360496544594 -0.785794252604781 0.863692107656202 -0.909808305111398 0.362923613900856 NA ESX conserved component EccC4 ESX-4 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv3448 eccD4 0.7 1.2 1.5 1.6 0 0 1.7431576159536 -0.89313919851369 1.66980845426874 -0.534875240468719 0.592736130368017 NA ESX conserved component EccD4 ESX-4 type VII secretion system protein Probable integral membrane protein II.C.5 - Other membrane proteins Rv3449 mycP4 2.1 1.3 0.6 0.8 1.5 4.1 3.14215669919173 0.377884350839932 1.24581268156674 0.303323570574593 0.761643285080776 NA Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3450c eccB4 8 8.9 2.7 14.7 6.5 3 15.5468620930626 0.213423481838918 0.616289835851283 0.346303750968269 0.729114449958646 NA ESX conserved component EccB4 ESX-4 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv3451 cut3 42.4 16 15.8 37.8 42 21.1 34.4316357187555 0.261527068711231 0.402045880800834 0.650490606172351 0.515375367682233 0.915911629458156 Probable cutinase precursor Cut3 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3452 cut4 61.1 40.9 29.4 38.5 65.9 55.4 52.5471545943078 0.0820992228746316 0.357461786649166 0.229672725703709 0.818346090121766 0.967203057682185 Probable cutinase precursor Cut4 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3453 - 7.3 4.8 5.3 1.3 5.8 2 1.66927188871975 -1.83111699082406 1.64880820218992 -1.11057003985788 0.266753464716056 NA Possible conserved transmembrane protein VI - Unknowns Rv3454 - 4.8 4.1 1.7 3.1 3.7 2.2 6.01783256474046 -0.516976808125908 0.860852176416248 -0.600540745889843 0.548145914304715 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3455c truA 162.1 76.8 58.9 185 178 111.2 151.884221315932 0.533799876602189 0.244866543115703 2.17996248001084 0.0292602428657045 0.361311748957762 Probable tRNA pseudouridine synthase a TruA (pseudouridylate synthase I) (pseudouridine synthase I) (uracil hydrolyase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3456c rplQ 735.7 405.2 310.7 742.7 576 546.5 471.221430389686 0.219073152462032 0.186817011613578 1.17266168947812 0.240931500288041 0.78958848015113 50S ribosomal protein L17 RplQ II.A.1 - Ribosomal protein synthesis and modification Rv3457c rpoA 406 198.1 210.7 317 329.2 304.3 490.097943993249 0.0627284247624167 0.198138336265221 0.316589035442644 0.751555456598106 0.959593750764785 Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3458c rpsD 533.3 241.6 254.5 373 472.6 367.1 358.12590931055 0.0808594414553152 0.215140008587065 0.375845673644623 0.707031630340454 0.949890877982223 30S ribosomal protein S4 RpsD II.A.1 - Ribosomal protein synthesis and modification Rv3459c rpsK 571.1 280.6 372.2 394.6 479.9 404 283.743536562054 -0.143189104395758 0.237638346549241 -0.602550499424924 0.546807758946707 0.92521033104044 30S ribosomal protein S11 RpsK II.A.1 - Ribosomal protein synthesis and modification Rv3460c rpsM 672.2 345.9 502.7 425.1 647.6 608.8 329.668948907104 -0.0666942850481887 0.273880739591272 -0.243515791390517 0.807605853475278 0.965592404376002 30S ribosomal protein S13 RpsM II.A.1 - Ribosomal protein synthesis and modification Rv3461c rpmJ 1879.4 1465.3 1343.6 304.6 1394.6 1462.1 253.472983577076 -0.73378623775591 0.726908940743937 -1.00946101585287 0.312753588817398 0.846061021823653 50S ribosomal protein L36 RpmJ II.A.1 - Ribosomal protein synthesis and modification Rv3462c infA 2110 1909.2 1903.4 951.5 2522.1 2211.4 727.847523929236 -0.286960226384568 0.53854030933253 -0.532848185013723 0.594138675567985 0.929159985017801 Probable translation initiation factor if-1 InfA II.A.6 - Protein translation and modification Rv3463 - 10.7 12.5 6.9 7.4 11.8 6.4 12.8085973765227 -0.428828603737067 0.621501731743865 -0.689987785768226 0.490201868463258 NA hypothetical protein II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3464 rmlB 346.1 262 242.5 214.5 352.7 331.6 480.163238872837 -0.12706240770751 0.257017518375212 -0.494372556823208 0.62104309159083 0.931582271037618 dTDP-glucose 4,6-dehydratase RmlB I.C.3 - Sugar nucleotides Rv3465 rmlC 221.3 163.5 100.4 174 156.7 158.9 158.858246230191 -0.148108212193648 0.23568026172817 -0.628428579922715 0.529723219551885 0.922751607774049 dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase) I.C.3 - Sugar nucleotides Rv3466 - 80.2 42.7 39.4 70.6 65.6 43.2 59.5451146300068 -0.00433583420433994 0.310430176885074 -0.0139671801493227 0.988856164929245 0.999120249206713 hypothetical protein IV.B.2 - REP13E12 family Rv3467 - 12.7 4.5 13.6 8.1 10.7 7.2 15.0527854774283 -0.549871455306255 0.608074941550269 -0.904282379905961 0.365845687457816 NA hypothetical protein IV.B.2 - REP13E12 family Rv3468c - 7 6.6 1 6.8 8.5 12.3 11.4044160681209 0.748284105959151 0.692683547078901 1.08026834059322 0.280022703548564 NA Possible dTDP-glucose 4,6-dehydratase I.C.3 - Sugar nucleotides Rv3469c mhpE 15.4 11.6 5.3 13.2 5.7 16.8 18.1701555701921 0.0117933455944885 0.549122923556455 0.0214766950869718 0.982865393801533 NA Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA) II.B.6 - Aromatic hydrocarbons Rv3470c ilvB2 9 10.6 3.2 13.6 5.4 12.3 23.9665646331236 0.356365172427779 0.510655891380512 0.697857752045861 0.485266157725936 NA Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS) I.D.7 - Branched amino acid family Rv3471c - 0.9 0 0 0 0 0 0.0896015681525148 -0.706868028450054 4.02314057484366 -0.17570055415663 0.860529199923768 NA hypothetical protein V - Conserved hypotheticals Rv3472 - 17.3 9.7 8.5 24 18 16.8 11.9566856502156 0.645903664363093 0.610434298185676 1.05810513315329 0.290007514459855 NA hypothetical protein I.H.1 - Synthesis of fatty and mycolic acids Rv3473c bpoA 0.8 1.1 0 0.7 0 0 0.186384600704998 -0.0729724104909624 3.99857105658927 -0.0182496220420319 0.985439716550585 NA Possible peroxidase BpoA (non-haem peroxidase) III.F - Detoxification Rv3474 - 11 3.3 11.6 6.9 0.6 9.4 3.28595969756353 -1.2603942564205 1.23178574986771 -1.02322522935166 0.306201366775066 NA Possible transposase for insertion element IS6110 (fragment) IV.B.1.a - IS6110 Rv3475 - 4.7 7.3 3 4.1 7.5 5.8 8.30169782020257 -0.0526192151435963 0.769507312203191 -0.0683803965331287 0.945482826599249 NA Possible transposase for insertion element IS6110 [second part] IV.B.1.a - IS6110 Rv3476c kgtP 12.4 11.3 2.7 12.4 7 13.8 20.1638935750982 0.209883562113837 0.535831244917484 0.39169713245475 0.695282009049722 NA Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) III.A.3 - Carbohydrates, organic acids and alcohols Rv3477 PE31 844.4 651.6 468.1 1071.7 995.5 1032.2 401.501937620401 0.47546575741381 0.202732887123254 2.34528183444033 0.0190127017968134 0.288108079878605 PE family protein PE31 IV.C.1.a - PE subfamily Rv3478 PPE60 995.9 762.9 468.2 1077.1 951.2 837.8 1597.28186745679 0.191969207993642 0.175181783866577 1.0958285944836 0.27315379237509 0.813286748879977 PE family protein PPE60 IV.C.2 - PPE family Rv3479 - 104.6 89.6 48.3 104 121.4 101.9 465.094388742788 0.263032384709883 0.215230227061162 1.22209778942963 0.221670648977509 0.774556499980442 Possible transmembrane protein VI - Unknowns Rv3480c - 62.7 30.2 20.7 57.9 34 45.4 96.3252164016339 0.147137070050462 0.293888131806155 0.500656726578914 0.616612732082787 0.931582271037618 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3481c - 12.2 2.6 3.9 24.2 34.9 20.2 16.4010573325029 1.88327321458517 0.597035251763124 3.15437523835253 0.00160842133079573 NA Probable integral membrane protein II.C.5 - Other membrane proteins Rv3482c - 38.8 21.5 20.5 108.6 84.2 84.9 72.3616824857977 1.61029542411395 0.299539827875291 5.37589754102539 7.62021181732502e-08 1.50553613476579e-05 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv3483c - 58.8 41.6 28.7 172.8 166.7 165.1 108.410933564742 1.82397313373758 0.26640995119725 6.84649025136118 7.56838006293122e-12 2.99059132200968e-09 Possible exported protein V - Conserved hypotheticals Rv3484 cpsA 139.7 97.7 85.1 0.9 0.9 1 144.089782173197 -7.52470601244337 0.699027382939353 -10.7645368351703 5.06154191404043e-27 1.40002249342358e-23 Possible conserved protein CpsA V - Conserved hypotheticals Rv3485c - 102.7 159.9 55 143 147.9 132.4 189.680055344365 0.20935133572979 0.313530345005555 0.667722723062358 0.504310602455498 0.915911629458156 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3486 - 16.9 10.6 16.5 38.7 25.8 32 16.2800651929288 0.954119080073041 0.556561381690313 1.71431060699059 0.0864716961282379 NA hypothetical protein V - Conserved hypotheticals Rv3487c lipF 800.8 730.9 440.6 818.6 961.4 704.4 997.767579059228 0.131942507802022 0.202086020922639 0.652902695592837 0.513819011051144 0.915911629458156 Probable esterase/lipase LipF II.B.5 - Esterases and lipases Rv3488 - 23.5 33.4 0 19.6 17.8 42.4 11.62881103975 0.423488238397278 0.773726813310493 0.547335611370798 0.58414818248283 NA hypothetical protein V - Conserved hypotheticals Rv3489 - 3351.8 2454.7 1518.3 4298.9 2828 4138.2 814.962166519571 0.475717980559059 0.222777035122728 2.13539955003434 0.0327283874129076 0.383117660251623 hypothetical protein VI - Unknowns Rv3490 otsA 573.4 411.7 246.2 510 503.4 418.2 1060.19903888081 0.0620444623209279 0.178702794572181 0.347193576180293 0.728445896505657 0.949890877982223 Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase) III.E - Adaptations and atypical conditions Rv3491 - 479.2 344.4 220.7 302.5 399.1 308.6 318.174824774492 -0.213489626968411 0.216994244243447 -0.983849261590991 0.325189634039413 0.853347384539607 hypothetical protein VI - Unknowns Rv3492c - 152.6 118.4 104.9 114.7 125.6 80.6 91.0907816568322 -0.450146617658226 0.283267119317357 -1.58912414099819 0.112032368534526 0.648445531184945 Conserved hypothetical Mce associated protein V - Conserved hypotheticals Rv3493c - 107.6 44.1 61.1 110.6 109.2 71.9 95.868780920981 0.253948553611059 0.281189439430876 0.903122656828961 0.366460800491242 0.883373818299354 Conserved hypothetical Mce associated alanine and valine rich protein VI - Unknowns Rv3494c mce4F 97.5 42 55.2 69.7 66.2 66.1 179.288902564643 -0.13224108117606 0.245367146517838 -0.538951864798437 0.589920068667336 0.928941202821899 Mce-family protein Mce4F IV.A - Virulence Rv3495c lprN 119.8 83.5 50 90.3 97.9 88.7 162.410590945547 -0.0260519545168272 0.237231341040779 -0.109816664200153 0.912554774857689 0.9932884147079 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) II.C.1 - Lipoproteins(lppA-lpr0) Rv3496c mce4D 127.9 69.2 69.5 91.6 110.9 81.6 198.952713661195 -0.0928336827919605 0.22523944114072 -0.412155536889128 0.680225424473986 0.942913432418385 Mce-family protein Mce4D IV.A - Virulence Rv3497c mce4C 95.6 49.8 54.8 71 58.6 52.9 109.594907433288 -0.320829954068737 0.259641374873786 -1.2356657494388 0.216582833850276 0.773070552038584 Mce-family protein Mce4C IV.A - Virulence Rv3498c mce4B 77 38.3 27.8 71.3 70.4 42.1 87.9402293392404 0.231852011220838 0.282135440601605 0.821775565403815 0.411204642815693 0.901158530199572 Mce-family protein Mce4B IV.A - Virulence Rv3499c mce4A 65.7 31.6 33.1 41.7 53.9 48.8 87.3674979320156 -0.0445318438091082 0.290416410454518 -0.153337904491738 0.878131810646779 0.980703859230131 Mce-family protein Mce4A IV.A - Virulence Rv3500c yrbE4B 24.5 10.6 12.1 26.1 20.7 8.6 21.5736273489127 0.107393145706204 0.489653182922661 0.219324921090457 0.826396950237322 NA Conserved integral membrane protein YrbE4B Possible ABC transporter IV.A - Virulence Rv3501c yrbE4A 18.4 11.5 10.5 20.2 15.9 12.8 17.4395199829453 0.113877629585981 0.513742101716304 0.22166302743252 0.824576213935853 NA Conserved integral membrane protein YrbE4A Possible ABC transporter IV.A - Virulence Rv3502c - 32.6 9.6 13.3 20 23.2 16.1 27.8314588226097 -0.0453171963675544 0.445327559172752 -0.101761490916341 0.918945992717047 0.9932884147079 Probable short-chain type dehydrogenase/reductase Possible 17-beta-hydroxysteroid dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3503c fdxD 116.8 27.1 31 107.7 94.7 55 20.3211352660481 0.418125222800283 0.521522992363288 0.801738809070609 0.422704061445851 NA Probable ferredoxin FdxD I.B.6.c - Electron transport Rv3504 fadE26 15 4.2 6.2 6.1 4.6 7.1 13.2309678275392 -0.65289874302708 0.621897924507634 -1.04984872484337 0.29378766918919 NA Probable acyl-CoA dehydrogenase FadE26 I.A.3 - Fatty acids Rv3505 fadE27 15.2 3.1 8.9 12.1 5 2.5 13.1271625181959 -0.589921524936051 0.680868487182901 -0.866425067455913 0.386257102134791 NA Probable acyl-CoA dehydrogenase FadE27 I.A.3 - Fatty acids Rv3506 fadD17 9 0.6 4.6 4.5 5.1 0 8.34522955154259 -0.685248677121357 0.882475483524843 -0.776507325035581 0.437449497472991 NA Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) I.A.3 - Fatty acids Rv3507 PE_PGRS53 17.5 7 9.6 26.7 13.9 12.1 92.833991225755 0.460139824821822 0.314721868061571 1.46205228017966 0.143726884020085 0.690135194188255 PE-PGRS family protein PE_PGRS53 IV.C.1.b - PE_PGRS subfamily Rv3508 PE_PGRS54 40.4 16.4 17.1 53.4 16.7 16.3 233.144043026591 0.0714899498361795 0.332634568612609 0.214920385858746 0.829829390648636 0.968638603196576 PE-PGRS family protein PE_PGRS54 IV.C.1.b - PE_PGRS subfamily Rv3509c ilvX 38.3 25.8 18.9 57.9 38.5 24.3 81.4537415358394 0.397864679597919 0.301029031349359 1.32168209097473 0.186274034692039 0.739746500217031 Probable acetohydroxyacid synthase IlvX (acetolactate synthase) I.D.7 - Branched amino acid family Rv3510c - 23 24.6 9.2 24.4 15.3 19.2 25.2735667112566 -0.0785913432818257 0.463670803407199 -0.169498149774175 0.865404827572135 NA hypothetical protein V - Conserved hypotheticals Rv3511 PE_PGRS55 12.7 6.6 10.4 16.7 10.3 8.7 36.6379299908279 0.0432065167538616 0.410545818021544 0.105241643824501 0.916184067185493 0.9932884147079 PE-PGRS family protein PE_PGRS55 IV.C.1.b - PE_PGRS subfamily Rv3512 PE_PGRS56 8.8 5.3 5.2 14.1 5 7.6 38.5334772811759 0.334971173327903 0.414148819493872 0.808818370500895 0.418619627823436 0.901158530199572 PE-PGRS family protein PE_PGRS56 IV.C.1.b - PE_PGRS subfamily Rv3513c fadD18 8.3 9.2 4.9 5.9 3.7 8.6 6.90402292440554 -0.547454526635162 0.821377642292613 -0.666507704187222 0.505086640969067 NA Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3514 PE_PGRS57 29.8 8.9 12.4 35.6 13.1 8.1 121.368715869577 0.0110993865042056 0.379635257946237 0.0292369748907185 0.97667559213081 0.998153412295216 PE-PGRS family protein PE_PGRS57 IV.C.1.b - PE_PGRS subfamily Rv3515c fadD19 7.3 5.3 4.1 5.1 6.9 7.1 15.2132622384793 -0.0753841723505411 0.557083459165197 -0.135319351365244 0.892359385622639 NA Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3516 echA19 34 17.9 22.8 16.2 16.4 19.1 26.742589221243 -0.846712314046332 0.44934124894828 -1.88434139093202 0.0595188120679287 NA Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3517 - 4.7 2.1 1.3 2.9 7.7 1.8 3.2165741326148 0.361353140401214 1.20062454226016 0.300970976089637 0.7634366266997 NA hypothetical protein V - Conserved hypotheticals Rv3518c cyp142 66.6 40.9 23.9 74.9 55 42.8 93.8498018453112 0.272866085590008 0.278885011007624 0.978417895619882 0.327867680816385 0.853347384539607 Probable cytochrome P450 monooxygenase 142 Cyp142 IV.F - Cytochrome P450 enzymes Rv3519 - 339.2 221.3 158.2 267.8 258.2 143.2 260.07031675598 -0.272525156698714 0.216927523477525 -1.25629589242487 0.209008710623336 0.770341510876847 hypothetical protein VI - Unknowns Rv3520c - 211.1 125.4 98.2 166.9 155.3 116.9 240.707808307636 -0.148269572375136 0.202506779456695 -0.732170906934218 0.464064259231856 0.901158530199572 Possible coenzyme F420-dependent oxidoreductase IV.G - Coenzyme F420-dependent enzymes Rv3521 - 23.7 10.3 10.5 12.1 15 12.8 19.58137108495 -0.404850548531911 0.497472677672338 -0.813814640888815 0.415751146404677 NA hypothetical protein V - Conserved hypotheticals Rv3522 ltp4 14.2 11.3 7.3 14.5 17.9 7.3 19.7466033663149 0.117281664611441 0.497377248230914 0.23580022011178 0.81358769734834 NA Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4 I.J.1 - Repressors/activators Rv3523 ltp3 348.7 170.7 129.5 266.3 205.6 188.1 403.675414623365 -0.097137008579816 0.200836964927225 -0.483661006403948 0.628626471065054 0.93413540068838 Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3 I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3524 - 102.8 80.5 51.8 89.4 101.9 65.3 134.75080667863 -0.0561452238331225 0.247129101927596 -0.227189850953175 0.820276119142802 0.967203057682185 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv3525c - 10.9 9.2 6.3 6.3 16.4 5.4 6.86575535192743 -0.223654664786869 0.81921361528041 -0.273011410717721 0.784844444180718 NA Possible siderophore-binding protein I.G.14 - Iron utilisation Rv3526 kshA 92.8 65.8 60.1 82.2 69.7 63.2 136.311581249785 -0.216814924482361 0.245054401159546 -0.884762417881246 0.376284783045736 0.891099066699062 Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3527 - 67 30.8 51.1 32 29.5 39.9 30.8246705690782 -0.829185542649981 0.439756489972228 -1.88555612380467 0.0593547946926445 0.499013258722963 Hypothetical protein VI - Unknowns Rv3528c - 41.5 36.7 37.2 20.4 30.4 90.1 51.8552727897907 0.026241500963044 0.497077244503215 0.0527915957795858 0.957897957760932 0.998153412295216 hypothetical protein VI - Unknowns Rv3529c - 15.3 9.9 10 5.4 2.4 5.7 15.2009084685152 -1.76906075228999 0.60712586621134 -2.91382866509953 0.00357025796056136 NA hypothetical protein V - Conserved hypotheticals Rv3530c - 16.6 19.9 13.4 7.8 9.5 16 18.2181183738749 -0.968062379958407 0.573204413451545 -1.68886065292001 0.0912461371661376 NA Possible oxidoreductase II.B.6 - Aromatic hydrocarbons Rv3531c - 18.8 9.7 7.3 11.1 6.6 12.6 19.0310520191465 -0.437594131615419 0.517592297576172 -0.845441737955964 0.397864249217277 NA Hypothetical protein VI - Unknowns Rv3532 PPE61 6.4 6.7 5 8.7 3.1 10.8 12.9414431520738 0.126775141993514 0.635601604712432 0.199456925617535 0.841905334706873 NA PPE family protein PPE61 IV.C.2 - PPE family Rv3533c PPE62 15.4 12.6 20.1 6.4 6.8 8.8 36.049478142042 -1.51279028230291 0.472876484232993 -3.19912351902349 0.00137846095749365 0.0611725004333888 PPE family protein PPE62 IV.C.2 - PPE family Rv3534c hsaF 28.6 13.8 13.7 21.9 17.9 12.7 28.7790339380484 -0.274949674698559 0.420316952175928 -0.654148430785813 0.513016181898075 0.915911629458156 Probable 4-hydroxy-2-oxovalerate aldolase (HOA) II.B.6 - Aromatic hydrocarbons Rv3535c hsaG 28.2 12 18.7 11.8 20.2 8.1 23.8373980509581 -0.813105384654717 0.486923056208479 -1.66988474726607 0.0949421686623576 NA Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3536c hsaE 44.2 26.9 36.1 27 33.7 33.3 43.4501337554756 -0.474470691601399 0.384356774403285 -1.23445382831619 0.217033841554823 0.773070552038584 Probable hydratase II.B.6 - Aromatic hydrocarbons Rv3537 kstD 25.3 13 28.7 9.4 18.6 9.7 50.5743283184933 -1.17960234106126 0.435084982183295 -2.7111998560417 0.00670402048392056 0.161324912772436 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3538 - 19.2 8.2 13.8 6.7 4.2 7.3 13.5168477033906 -1.50115096773337 0.634123175738103 -2.36728608126658 0.0179190756598476 NA Probable dehydrogenase Possible 2-enoyl acyl-CoA hydratase I.H.2 - Modification of fatty and mycolic acids Rv3539 PPE63 4.5 2.6 2.5 5.8 2.6 0 6.2265937502267 -0.152603436415519 0.890180776331104 -0.171429714585027 0.863885891742529 NA PPE family protein PPE63 IV.C.1.a - PE subfamily Rv3540c ltp2 42.3 12 25 19.9 21.6 9.8 39.7383791937513 -0.843088901578269 0.418104894164255 -2.01645307994662 0.0437526198371533 0.418788752385911 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 III.A.5 - Fatty acid transport Rv3541c - 39.2 27 19 18 22.4 14.5 14.1533390699259 -0.88650198320854 0.578172491045555 -1.53328288173207 0.125206170528201 NA hypothetical protein VI - Unknowns Rv3542c - 53.2 22.9 39.4 24.3 22.7 17.4 45.9892506854093 -1.07657471626181 0.382497507257714 -2.81459276422539 0.00488390798520696 0.136453429162449 hypothetical protein VI - Unknowns Rv3543c fadE29 56.5 18.2 37.2 25.8 23.7 22.9 57.7215053415783 -0.871377626133466 0.364296961069196 -2.39194316520239 0.0167594373949825 0.276757764055105 Probable acyl-CoA dehydrogenase FadE29 I.A.3 - Fatty acids Rv3544c fadE28 55.4 28.6 39.5 26.3 26.8 30.9 58.0803916557329 -0.826974327376406 0.345114519371189 -2.39623163025184 0.0165646187325325 0.276757764055105 Probable acyl-CoA dehydrogenase FadE28 I.A.3 - Fatty acids Rv3545c cyp125 37.2 22.3 17.8 21.9 20.9 14.9 46.5386784146896 -0.606739799521848 0.341726805985344 -1.77551128238933 0.0758135043161426 0.545639518948021 Probable cytochrome P450 125 Cyp125 IV.F - Cytochrome P450 enzymes Rv3546 fadA5 23.8 10.3 10 11.3 12.3 12 24.3272105971735 -0.495134641884389 0.456718458001604 -1.08411349094774 0.278314481879456 NA Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv3547 ddn 100.1 70.1 66.3 51.7 75.2 75.2 54.6584403264786 -0.482335604826347 0.353775099222197 -1.36339614033548 0.172757696853305 0.730136729083316 Deazaflavin-dependent nitroreductase Ddn V - Conserved hypotheticals Rv3548c - 48.8 32.9 24.5 43 50.3 24.8 53.6296159246029 -0.0137530610744374 0.329530594045956 -0.0417353087177071 0.966709706186236 0.998153412295216 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3549c - 76.2 50.4 38.3 61.4 77.6 81.6 80.2212042094256 0.221260470365993 0.300589395240065 0.736088743880279 0.461676692474356 0.901158530199572 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3550 echA20 42.9 11.5 15 41 40.5 14.7 30.3738590868953 0.331365756834514 0.452888268813625 0.731672201849149 0.464368667251323 0.901158530199572 Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3551 - 47 25.8 20.4 44.8 44.6 29.2 47.8788481602801 0.210575611703272 0.336524979860393 0.625735455925526 0.531488473204189 0.922751607774049 Possible CoA-transferase (alpha subunit) I.A.2 - Amino acids and amines Rv3552 - 42.4 43.8 20.2 34.2 32.4 34.2 41.8208718326132 -0.228316674073999 0.378352413459422 -0.603449762580901 0.546209526276238 0.92521033104044 Possible CoA-transferase (beta subunit) VI - Unknowns Rv3553 - 34.4 18.6 18.2 31.6 38.8 26.5 46.8717835061364 0.236966271239191 0.342798189102478 0.691270487337232 0.489395574783665 0.910063990546522 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3554 fdxB 20 10.1 10.4 15.7 16.7 13.1 46.1635904465545 -0.0520005481263714 0.341899625396317 -0.15209302457145 0.879113565790139 0.980703859230131 Possible electron transfer protein FdxB I.B.6.c - Electron transport Rv3555c - 41.2 14.6 19.1 32.7 29.2 15.1 33.2840823970814 -0.133810181486029 0.411689735837363 -0.325026761266864 0.745160817793295 0.956095160416489 hypothetical protein V - Conserved hypotheticals Rv3556c fadA6 105.3 73.3 44.8 83.6 103.4 64.1 144.609309970111 0.00636384367348087 0.24596397468768 0.025873072191005 0.979358578133159 0.998567088804884 Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv3557c - 113.8 66.6 50.2 75 83.2 79 74.7168080859985 -0.132180511703536 0.292263392090017 -0.452265029699048 0.651078065468803 0.939577115195416 Transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3558 PPE64 8.9 4.9 3.7 6.6 11.8 1.7 15.0715730677867 0.0434666165063328 0.598317636117989 0.0726480616355443 0.94208618007918 NA PPE family protein PPE64 IV.C.2 - PPE family Rv3559c - 24.5 5.2 15.3 39.2 22.2 22.9 25.7905895694351 0.68929105951194 0.478695610589068 1.43993603505936 0.149885496858677 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3560c fadE30 13.3 11.4 8.6 21.4 29.4 11.4 28.0115080734117 0.730429609725304 0.442253208999799 1.65160951884837 0.098614178297338 0.615726449594665 Probable acyl-CoA dehydrogenase FadE30 I.A.3 - Fatty acids Rv3561 fadD3 39.7 26.7 19.1 43 33.6 29 76.7554166006439 0.15517116644483 0.283346229480353 0.547638014204066 0.583940481855107 0.928941202821899 Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3562 fadE31 35.1 23.7 20.1 34.8 36.4 40.3 57.5024808643214 0.288434730731758 0.323694973456281 0.891069538868557 0.372891865396205 0.88686061881849 Probable acyl-CoA dehydrogenase FadE31 I.A.3 - Fatty acids Rv3563 fadE32 22.3 11.8 14 19.8 21.6 22.8 28.1985400299058 0.161154102195036 0.424399136422079 0.379722973881745 0.704151064610154 0.94870036274315 Probable acyl-CoA dehydrogenase FadE32 I.A.3 - Fatty acids Rv3564 fadE33 14.8 13.1 12.1 20.7 6.2 19.2 22.2581405129398 -0.0417331622306771 0.520468382711242 -0.0801838567278176 0.936091029282054 NA Probable acyl-CoA dehydrogenase FadE33 I.A.3 - Fatty acids Rv3565 aspB 12.3 3 8.6 14.6 1.6 7.3 14.3088154942483 -0.180354196899915 0.694832893253787 -0.259564851708944 0.795199451492569 NA Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) I.D.2 - Aspartate family Rv3566c nat 54.9 30 28.7 44.1 38.8 34.8 51.8626834377869 -0.137929705714871 0.326259478686927 -0.42276076167959 0.672469818688874 0.940710721884994 Arylamine N-acetyltransferase Nat (arylamine acetylase) I.C.1 - General Rv3566A - 106.1 76.2 40.3 99.4 67.7 66.8 31.3664340438938 -0.0407985087721638 0.407991324717881 -0.0999984712919455 0.920345539095148 0.9932884147079 Hypothetical protein ? Rv3567c hsaB 76.5 48.3 35.9 64.5 53.2 57.7 50.1692909787686 -0.0373758002671676 0.331208783690962 -0.112846645703822 0.910152136579967 0.992834063067731 Possible oxidoreductase Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase V - Conserved hypotheticals Rv3568c hsaC 75.6 41.8 48.2 94.5 70.1 70.4 95.9615405273283 0.318495206115824 0.274631082365563 1.15972017213941 0.246162754486165 0.791634949201473 3,4-DHSA dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3569c hsaD 80 43.3 42.7 77.7 68.1 57.3 84.9865272489035 0.109913137948098 0.273589802314144 0.401744279276506 0.68787223356475 0.942913432418385 4,9-DHSA hydrolase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3570c hsaA 163.6 126.6 107.8 146 132.9 129.9 260.392426855643 -0.171235951260292 0.218178271603948 -0.784844201035431 0.43254492092458 0.901158530199572 Possible oxidoreductase Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3571 kshB 32.9 19.6 15.5 34.3 35.4 24.3 45.0912686673304 0.309474561110348 0.342314053413244 0.904066187246915 0.365960306394206 0.883373818299354 Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3572 - 113.4 89.6 58.5 62.2 104.1 54 68.2710499141641 -0.471395606824553 0.325172380480601 -1.44967910905544 0.147148024051417 0.695223866622759 hypothetical protein VI - Unknowns Rv3573c fadE34 4.6 2.4 2.4 4.5 0.4 4 10.2787722934356 -0.315557353231407 0.749335123416477 -0.421116458271264 0.673670043994683 NA Probable acyl-CoA dehydrogenase FadE34 I.A.3 - Fatty acids Rv3574 kstR 69.3 38 37.8 58.1 45.1 30.1 43.9046708152285 -0.290673205564492 0.356801592093275 -0.814663420808124 0.415264997013053 0.901158530199572 Transcriptional regulatory protein KstR (probably TetR-family) I.J.1 - Repressors/activators Rv3575c - 11 4.8 5.5 16.4 7.9 3.9 13.1806448944557 0.239381271591635 0.626842029775709 0.38188452627736 0.702547018272087 NA Transcriptional regulatory protein (probably LacI-family) I.J.1 - Repressors/activators Rv3576 lppH 105.1 75.9 46.9 73.6 89.3 47.5 82.7684577047341 -0.275357501732127 0.287361123837956 -0.958228093120216 0.337947754048292 0.854445601186084 Possible conserved lipoprotein LppH V - Conserved hypotheticals Rv3577 - 43 33.8 20.7 45 22 34.2 45.5604432564725 -0.0858205449584788 0.368239844610443 -0.233056107899642 0.815717837276353 0.966726317518412 hypothetical protein VI - Unknowns Rv3578 arsB2 14.4 9.5 7.4 16.3 10.4 4.9 19.809750519196 -0.113861988235217 0.512718073534721 -0.22207523805479 0.82425531375156 NA Possible arsenical pump integral membrane protein ArsB2 III.A.4 - Anions Rv3579c - 81.6 38.6 50.2 89.5 69 38.8 93.6656068887406 0.0312189195995784 0.296473735873599 0.105300793365685 0.916137133462095 0.9932884147079 Possible tRNA/rRNA methyltransferase IV.H - Miscellaneous transferases Rv3580c cysS1 131.7 78.1 74.8 99 104.1 69.1 209.717412869878 -0.251538124983718 0.21691020648919 -1.15964172020764 0.246194707445553 0.791634949201473 Cysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3581c ispF 1131.3 526.1 441.7 812.1 531.8 401.7 479.712879104578 -0.398571209331928 0.218932162500344 -1.82052378590698 0.0686792773558624 0.520912460856883 Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) V - Conserved hypotheticals Rv3582c ispD 2362.6 1298.5 1234.8 1584.6 1316.2 1112.8 1660.35669616898 -0.460968811136003 0.165662978191663 -2.78256986665232 0.00539302522223592 0.140727431742496 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT) V - Conserved hypotheticals Rv3583c - 12646.9 7846.1 6407.8 12912.8 10700.4 8805.6 7681.17121500257 0.0904788264405077 0.152813219220985 0.592087693078864 0.553791867614203 0.92521033104044 Possible transcription factor I.J.1 - Repressors/activators Rv3584 lpqE 276.1 243.8 124.3 216.2 346.3 320.1 224.930022401973 0.292871631108726 0.275964183159334 1.06126682004827 0.288568660080956 0.83054472942914 Possible conserved lipoprotein LpqE II.C.1 - Lipoproteins(lppA-lpr0) Rv3585 radA 68.2 42.6 29.1 68.5 64 38.1 116.44441021675 0.138603172902267 0.254390897485234 0.544843287524909 0.585861304023925 0.928941202821899 DNA repair protein RadA (DNA repair protein SMS) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3586 - 38.6 18.3 15.5 38.2 43.6 25.1 49.051594059009 0.397011764309391 0.342004513525623 1.16083779192478 0.24570787090596 0.791634949201473 hypothetical protein V - Conserved hypotheticals Rv3587c - 107.5 52.9 53.5 90.4 89.1 65.6 95.4161892790015 0.014834602911487 0.265629352973535 0.0558470016412869 0.955463691449063 0.998153412295216 Probable conserved membrane protein VI - Unknowns Rv3588c canB 75.8 46.1 26.5 44.4 41.3 49.9 46.2353226024328 -0.285042697693485 0.356767376194296 -0.79895953697922 0.4243138747113 0.901158530199572 Beta-carbonic anhydrase CanB IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3589 mutY 23.8 12.6 12.3 23 20.9 15.5 25.6381914632579 0.114261329382885 0.432253211867242 0.264338878800462 0.791518804405024 NA Probable adenine glycosylase MutY II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3590c PE_PGRS58 13.4 6.9 2.3 17.8 6.1 22.2 30.3748321072094 0.942704177422673 0.516475217693977 1.82526507589614 0.0679610376989698 0.520912460856883 PE-PGRS family protein PE_PGRS58 IV.C.1.b - PE_PGRS subfamily Rv3591c - 5.3 0 0 8.7 9.5 7.3 5.39537999887393 1.92234002127683 1.0612426895727 1.81140472407009 0.0700782252515191 NA Possible hydrolase V - Conserved hypotheticals Rv3592 mhuD 533.5 372.8 223.9 535.8 478.2 433.4 215.836086534905 0.210528078602796 0.215994060782565 0.974693831117551 0.329712153859879 0.853347384539607 Possible heme degrading protein MhuD V - Conserved hypotheticals Rv3593 lpqF 177.4 152 90.5 147.7 180.7 206.2 350.650300041612 0.180039096084616 0.246863427414931 0.729306475122392 0.465814212319947 0.901158530199572 Probable conserved lipoprotein LpqF II.C.1 - Lipoproteins(lppA-lpr0) Rv3594 - 49.2 28.3 18.4 49.3 39.3 37.3 47.2679723232076 0.259623290336226 0.341578471619088 0.760069242963724 0.447213196341967 0.901158530199572 hypothetical protein VI - Unknowns Rv3595c PE_PGRS59 50 25 29.5 55.3 21.8 25.7 72.2873332124338 -0.170143722728384 0.34503585491768 -0.493118962285752 0.621928533182187 0.931582271037618 PE-PGRS family protein PE_PGRS59 IV.C.1.b - PE_PGRS subfamily Rv3596c clpC1 879.9 536.6 479.3 730.8 650.1 544.7 2604.48182657602 -0.160708850755392 0.157371707014366 -1.02120548734165 0.307157093098964 0.844880251285152 Probable ATP-dependent protease ATP-binding subunit ClpC1 II.B.3 - Proteins, peptides and glycopeptides Rv3597c lsr2 412.9 184.3 209.2 385.4 335.9 406.6 173.642450900098 0.317492631463692 0.247770434414807 1.2813983727056 0.200053775453755 0.759051773532356 Iron-regulated H-NS-like protein Lsr2 V - Conserved hypotheticals Rv3598c lysS 29 22.1 14.4 40.4 33.6 37.7 70.8665773736965 0.603309275818634 0.297758146897025 2.02617218741383 0.042747142691566 0.418767550294889 Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3599c - 43.6 38.2 24.9 34.9 89.7 27.5 5.18930199880772 0.167028892532707 0.930202264250603 0.179561907073265 0.857496512280723 NA Hypothetical short protein VI - Unknowns Rv3600c - 42.6 15.1 16.4 44.7 38.6 35 39.4843368109829 0.519442470107039 0.380188319963014 1.36627677083181 0.171852109138162 0.729574936755292 hypothetical protein V - Conserved hypotheticals Rv3601c panD 72.8 54.6 33.5 84.6 60.2 85.2 43.2810614216806 0.36192790246606 0.364996719477647 0.991592206593038 0.321396492535687 0.849868688356633 Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase) I.G.5 - Pantothenate Rv3602c panC 31 19.1 13.5 33.7 35 12.1 34.0655118615825 0.200198576571572 0.406977800439612 0.491915225733001 0.622779274280172 0.931582271037618 Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) I.G.5 - Pantothenate Rv3603c - 61.3 31.7 31.2 44.4 47.4 32.6 59.548818712408 -0.169827830980328 0.312372134620005 -0.543671512783689 0.586667539053219 0.928941202821899 Conserved hypothetical alanine and leucine rich protein VI - Unknowns Rv3604c - 101.1 57.8 49 105.3 93.9 46.5 140.783150869518 0.0767432369789878 0.256344283681462 0.299375651669886 0.764653437886083 0.959593750764785 Probable conserved transmembrane protein rich in alanine and arginine and proline II.C.5 - Other membrane proteins Rv3605c - 91.8 52.1 42.7 165.7 73.7 59.5 58.7592428210589 0.535087531720022 0.364433599355243 1.46827167601094 0.142030441449002 0.685612916314031 Probable conserved secreted protein VI - Unknowns Rv3606c folK 87.4 63.1 46.7 108.8 50.8 53.6 61.0868443033904 -0.0373375327918245 0.34084393384318 -0.1095443664519 0.912770734136711 0.9932884147079 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase) I.G.2 - Folic acid Rv3607c folB 161.8 111.3 87.8 155.7 186.9 154 91.3277487488053 0.269283215227499 0.274038161391418 0.982648598502574 0.325780416978731 0.853347384539607 Probable dihydroneopterin aldolase FolB (DHNA) I.G.2 - Folic acid Rv3608c folP1 139.8 99 94.2 141 116.6 113.2 160.34002309456 -0.04948639011807 0.23946526817675 -0.206653726842525 0.836280297860714 0.970813891745226 Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1) I.G.2 - Folic acid Rv3609c folE 208.5 152.1 125.1 173.1 172.9 159.8 163.248420182228 -0.136289479175989 0.233191438545102 -0.584453185872982 0.558915452652108 0.92521033104044 GTP cyclohydrolase I FolE (GTP-ch-I) I.G.2 - Folic acid Rv3610c ftsH 330.6 204.4 177.6 219 280.9 187.9 857.040302675267 -0.234192959709985 0.186649993142695 -1.25471721571906 0.2095814338647 0.770341510876847 Membrane-bound protease FtsH (cell division protein) III.C - Cell division Rv3611 - 7.3 2.6 3.2 10.5 4.8 0 4.05904680406015 0.173636049777586 1.08580171986902 0.15991506239144 0.872947983145138 NA Hypothetical arginine and proline rich protein VI - Unknowns Rv3612c - 425.8 182.8 328.9 149.4 166.7 119.9 126.459737226638 -1.35035174443419 0.304702589736445 -4.43170419261021 9.34912191030342e-06 0.00107118777949321 hypothetical protein VI - Unknowns Rv3613c - 583.6 248.8 393.7 189.8 322.9 220 87.3990345388931 -0.986280618452799 0.332486683207654 -2.96637630397011 0.00301331547300768 0.0992241737897529 Hypothetical protein VI - Unknowns Rv3614c espD 860.2 340.7 498.7 351.7 405.3 382 426.947720481564 -0.751237193399122 0.241590450913312 -3.10954837229341 0.00187373600712844 0.0719826916071842 ESX-1 secretion-associated protein EspD V - Conserved hypotheticals Rv3615c espC 867.2 375.9 574.2 306.5 294.3 283.1 232.904932821355 -1.24873646727346 0.256619264498022 -4.86610570611734 1.13818657922913e-06 0.000158524329255714 ESX-1 secretion-associated protein EspC V - Conserved hypotheticals Rv3616c espA 1075.3 437.5 802.8 342.2 402.3 355.7 1127.59787301192 -1.28333304138762 0.258279649221569 -4.96877336350528 6.73777637977413e-07 0.000103537163702529 ESX-1 secretion-associated protein A, EspA V - Conserved hypotheticals Rv3617 ephA 32.4 21.9 20.4 35.6 25 30.7 42.5486418706207 0.0934653422001939 0.360968172843822 0.258929593331856 0.79568956444498 0.965360560531176 Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv3618 - 18.2 15.7 9.9 13.4 12.4 12 26.0362780925183 -0.405594401716149 0.440486635005537 -0.920787078388997 0.357161602548826 NA Possible monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3619c esxV 19.6 11 12.2 8.3 33.3 1.6 6.04680129378165 -0.299630647899288 0.917823516614143 -0.326457802045242 0.744078011002079 NA Putative ESAT-6 like protein EsxV (ESAT-6 like protein 1) V - Conserved hypotheticals Rv3620c esxW 27.3 44.1 23.1 33.6 31.3 14.5 13.5827556714614 -0.395926748610549 0.625608169525437 -0.632866973126141 0.52682051686551 NA Putative ESAT-6 like protein EsxW (ESAT-6 like protein 10) V - Conserved hypotheticals Rv3621c PPE65 3.3 4.3 2.4 4.1 1.5 2.3 5.41481519169823 -0.61702682412526 0.941188224447273 -0.655582813403364 0.512092586669974 NA PPE family protein PPE65 IV.C.2 - PPE family Rv3622c PE32 4 0.2 0 0.3 0 0 0.224003920381287 -1.3705150752187 4.01877258136825 -0.341028273551147 0.733082297003807 NA PE family protein PE32 IV.C.1.a - PE subfamily Rv3623 lpqG 41.4 37.5 31.2 49.3 52.6 50.9 51.3732842355867 0.247290710667126 0.349082764146215 0.708401376596032 0.478696037822473 0.907292899730371 Probable conserved lipoprotein LpqG II.C.1 - Lipoproteins(lppA-lpr0) Rv3624c hpt 217.7 132.3 112.8 161.3 189.4 144.1 166.257774776598 -0.0863464215835504 0.228504164108369 -0.377876796777323 0.705522120163665 0.949622474147298 Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphorylase) (imp diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase) I.F.4 - Salvage of nucleosides and nucleotides Rv3625c mesJ 42.9 14.9 21.1 48.4 25.9 21.2 43.3568402268052 0.131216436148038 0.388957911617699 0.337353817029459 0.73585019477135 0.953602020109268 Possible cell cycle protein MesJ III.C - Cell division Rv3626c - 113 58 50 120 66.5 52.2 125.448042925496 -0.0266690001082316 0.278882474708452 -0.0956280961581102 0.923815949947828 0.995376050215915 hypothetical protein VI - Unknowns Rv3627c - 120 68.6 59.7 105.1 69.5 67.6 179.789946624641 -0.194003995569427 0.23120826051585 -0.839087648237927 0.401420126857106 0.893826103932853 hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv3628 ppa 33.9 10 14 31.1 44 23.5 18.6428797241938 0.573499302225362 0.52759280071828 1.08701123564344 0.277031844217856 NA Inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase) (PPASE) (inorganic diphosphatase) (diphosphate phospho-hydrolase) I.A.4 - Phosphorous compounds Rv3629c - 33.6 30.3 12.9 34.6 42.6 25.8 51.4696673491641 0.266926066070044 0.349648311477888 0.763412999026952 0.445217129971519 0.901158530199572 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3630 - 28.2 8 8.3 18.1 25 15.3 33.2046081194099 0.227588810797275 0.430020320042197 0.529251293927093 0.596631138205369 0.929736184944254 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3631 - 56.9 43.8 31.7 52.7 45.1 50.6 54.1882733528305 -0.0178969844015004 0.326668082102492 -0.0547864495555007 0.956308595876836 0.998153412295216 Possible transferase (possibly glycosyltransferase) IV.H - Miscellaneous transferases Rv3632 - 33 20.5 10.8 51 66.3 11.7 15.8400160736652 0.933249842046623 0.588958758921381 1.58457587719007 0.113062729362891 NA Possible conserved membrane protein VI - Unknowns Rv3633 - 108.6 46 50.4 77.3 94.5 52 97.1771932597386 -0.0423685745477782 0.28177066382276 -0.150365456690797 0.880476292946982 0.980703859230131 hypothetical protein V - Conserved hypotheticals Rv3634c galE1 28.3 14.6 6.8 25.8 21.5 15 26.4797276142691 0.209123361945072 0.448553074486851 0.466217653695298 0.641059714257745 NA UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.C.3 - Sugar nucleotides Rv3635 - 8.6 6.8 3.3 10.7 8.8 13.9 24.1057082613729 0.677581566314267 0.46642372379963 1.45271677176813 0.146302408356031 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3636 - 31.6 30.3 14.4 53.9 44.8 21.5 17.2417035700895 0.579550864359287 0.53690559195729 1.07942787901786 0.280397028366452 NA Possible transposase IV.B.1.c - Others Rv3637 - 1.7 4.5 0 1.1 1 0.7 0.90147908001757 -1.84894475891545 2.24843708061128 -0.822324438099367 0.410892271663561 NA Possible transposase IV.B.1.c - Others Rv3638 - 0.7 0 0 0 0.7 0 0.0896015681525148 -0.706868028450054 4.02314057484366 -0.17570055415663 0.860529199923768 NA Possible transposase IV.B.1.c - Others Rv3639c - 0.7 1.9 1.1 1.3 0 0 0.811950567742682 -1.00758734378975 2.23627389337532 -0.450565266971369 0.652302904463915 NA hypothetical protein V - Conserved hypotheticals Rv3640c - 2.9 4.1 0.3 2.2 0 2.8 3.61949735327154 -0.377015729950851 1.22971585075396 -0.306587680169932 0.759157232132299 NA Probable transposase IV.B.1.c - Others Rv3641c fic 119 86.8 52.2 107.2 68.7 70.8 84.6683910335306 -0.20560030312598 0.288430960402243 -0.712823279578765 0.475955118327684 0.90542768727261 Possible cell filamentation protein Fic III.C - Cell division Rv3642c - 752.1 508.1 319.6 583.3 674.8 593.9 176.93219022214 0.0740042765188284 0.233340893590469 0.317150909041737 0.751129097366407 0.959593750764785 Hypothetical protein VI - Unknowns Rv3643 - 0 0 0 0 0 0 0 NA NA NA NA NA Hypothetical protein VI - Unknowns Rv3644c - 30.6 15.5 24.1 40.1 26.8 13.2 48.0617252719293 -0.0148526423699637 0.388566932213027 -0.0382241542927305 0.969508962625318 0.998153412295216 Possible DNA polymerase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3645 - 275.8 166.2 111.9 270.4 269.6 235.5 575.113393731393 0.344914093030819 0.182270966387212 1.89231505086823 0.058449016779463 0.498981421024675 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3646c topA 91.3 62.7 53.8 77.9 87.7 75 338.600756873868 0.0164404612981082 0.20371482422706 0.0807033133719506 0.935677901724582 0.998153412295216 DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3647c - 99.2 79.2 38.6 106.4 90.4 71.4 73.2979608469825 0.175651772775189 0.300160165371062 0.585193483479215 0.558417626092803 0.92521033104044 hypothetical protein VI - Unknowns Rv3648c cspA 4387.6 3527.7 1477.6 4218.6 4254.8 3711.6 1157.32261114932 0.243972371911526 0.222558290756212 1.09621785412959 0.272983448057567 0.813286748879977 Probable cold shock protein A CspA III.E - Adaptations and atypical conditions Rv3649 - 5.3 3.2 3.5 7.9 6 4.9 18.1370065594638 0.446398102623614 0.508262722921203 0.878282200311629 0.379790592904567 NA Probable helicase II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3650 PE33 9.1 9.8 5.3 7.6 21.2 19.9 4.98712651455281 0.862971543820119 0.973267620747737 0.886674461806424 0.375254191632596 NA PE family protein PE33 IV.C.1.a - PE subfamily Rv3651 - 67.8 57.6 42.3 78.9 139.6 91.8 131.997065691079 0.690219096103605 0.288702283241276 2.39076424458608 0.0168133453047756 0.276757764055105 hypothetical protein VI - Unknowns Rv3652 PE_PGRS60 24.7 20.8 35.6 29.9 18.6 43.7 15.414301276629 -0.11328658875874 0.62199393419113 -0.182134555550068 0.855477130847765 NA PE-PGRS family-related protein PE_PGRS60 IV.C.1.b - PE_PGRS subfamily Rv3653 PE_PGRS61 6.6 1.4 5.2 13.1 3.5 10.6 5.30117837118623 0.870523994418881 0.989759439222401 0.879530883891143 0.37911349531221 NA PE-PGRS family-related protein PE_PGRS61 IV.C.1.b - PE_PGRS subfamily Rv3654c - 14.6 6.8 7.2 28 12.5 3.7 3.67098865324992 0.57320580410151 1.13593992721819 0.504609258260019 0.61383330588183 NA hypothetical protein VI - Unknowns Rv3655c - 25.3 12.2 12.9 18.5 11.8 17.4 9.17611040491376 -0.294927843741413 0.695314978757731 -0.424164375501214 0.671445939522124 NA hypothetical protein VI - Unknowns Rv3656c - 21.8 17.5 5.2 17.2 5.1 7.9 3.65729768106024 -0.42604276696006 1.1059684156388 -0.385221459252957 0.700073345701914 NA hypothetical protein VI - Unknowns Rv3657c - 9.4 5 6.5 11.3 4.2 11.5 6.4936435056659 0.173922673914846 0.831079900100974 0.209273108269992 0.834235043474841 NA Possible conserved alanine rich membrane protein VI - Unknowns Rv3658c - 18.9 13.7 3.6 20.1 14.4 24.9 19.1637363665372 0.588683843133449 0.538045989015996 1.0941143603915 0.273904824982769 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3659c - 21.1 16.6 9.8 9.5 13.6 13.3 23.9749715419077 -0.624192469718168 0.472470560015392 -1.32112457905914 0.18645982880601 NA hypothetical protein II.C.5 - Other membrane proteins Rv3660c - 70.8 30.7 37.8 49.3 35.6 16.4 66.3565256309352 -0.604513470433936 0.339265400109186 -1.78183059704698 0.0747768610611888 0.54162997700187 hypothetical protein IV.E - Bacteriocin-like proteins Rv3661 - 70.2 64.8 51.6 53.4 60.5 35.5 79.8968495598246 -0.536866290474785 0.306766264615424 -1.75008256252631 0.0801040682099917 0.554416577209112 hypothetical protein IV.E - Bacteriocin-like proteins Rv3662c - 19.5 13.1 8.3 25.8 19.1 9.3 18.4509709045076 0.302302621353271 0.512796799034291 0.5895173720323 0.555514262097033 NA hypothetical protein VI - Unknowns Rv3663c dppD 21.1 13.4 11.7 19.1 10.1 12 37.9616499761713 -0.312751913102202 0.383578763136657 -0.815352525110411 0.414870550999004 0.901158530199572 Probable dipeptide-transport ATP-binding protein ABC transporter DppD III.A.1 - Amino acids Rv3664c dppC 13.9 5.9 5.5 8.4 4.6 0.7 7.34668033977966 -0.88665798020067 0.832903717676583 -1.06453838707076 0.287084874251151 NA Probable dipeptide-transport integral membrane protein ABC transporter DppC III.A.1 - Amino acids Rv3665c dppB 5.1 7.1 2.3 8.2 10.8 11.4 10.8670576890803 0.994209914419249 0.6769571933016 1.46864517322044 0.141929055540207 NA Probable dipeptide-transport integral membrane protein ABC transporter DppB III.A.1 - Amino acids Rv3666c dppA 11.4 8.5 4.6 12.8 7.6 15.1 25.4714213447023 0.383177524252165 0.461048914491433 0.831099504213853 0.405917419800734 NA Probable periplasmic dipeptide-binding lipoprotein DppA III.A.1 - Amino acids Rv3667 acs 22 20.1 14 19 11.7 22.7 58.8544402105978 -0.284637867236435 0.356626189027669 -0.798140675009012 0.424788859621935 0.901158530199572 Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) I.A.3 - Fatty acids Rv3668c - 20.8 4.8 13.2 25.2 9.2 11.6 14.7838639328583 0.0269548517288813 0.621176372632699 0.0433932340578892 0.96538807106253 NA Possible protease II.B.3 - Proteins, peptides and glycopeptides Rv3669 - 66.4 40.2 38.6 81.3 63.2 50.4 46.3065127559871 0.248139371123448 0.343798270383279 0.72175863725787 0.470442883963 0.902597484602108 Probable conserved transmembrane protein VI - Unknowns Rv3670 ephE 20.9 8.7 4.2 13.8 9.6 14.4 17.4717818474595 0.0317328012360548 0.552651262750364 0.0574192142041457 0.954211257530187 NA Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv3671c - 67.9 44.1 16.2 80.2 66.6 62.7 103.083587792769 0.613324160396114 0.297079217947765 2.06451385133225 0.0389690219736933 0.405219228493367 Membrane-associated serine protease II.B.3 - Proteins, peptides and glycopeptides Rv3672c - 73.6 33.4 36.6 88.2 62.5 37.6 70.1516315931917 0.247554266975006 0.316521246989835 0.782109477102358 0.434150237596625 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv3673c - 118.8 66.6 55.1 119.6 97.9 111 102.352623892953 0.278933401904441 0.261826742932149 1.06533579717915 0.286723999027632 0.829758572569927 Possible membrane-anchored thioredoxin-like protein (thiol-disulfide interchange related protein) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3674c nth 78.8 57.8 38 82.1 105 61.3 81.4740596913457 0.3308981166261 0.287753120084129 1.1499375455229 0.250169595482021 0.796128980119145 Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3675 - 67.8 29.6 9.2 86.4 63.5 39.6 26.6086417744561 0.757773761779772 0.496510030151965 1.52620030968527 0.126959986376183 NA Possible membrane protein VI - Unknowns Rv3676 crp 121.4 56.2 85.1 132.4 161.4 128.1 122.809184970411 0.4626315636644 0.278882645838514 1.65887541074279 0.0971409004872609 0.610663024426736 Transcriptional regulatory protein Crp (Crp/Fnr-family) I.J.1 - Repressors/activators Rv3677c - 276.4 171.6 130.6 240.2 239.7 180.1 259.855161827334 0.0255171975150444 0.198765869135194 0.128378164853285 0.897849710084475 0.98854987613174 Possible hydrolase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3678c - 363.9 195 203.9 344.7 269.6 227.7 193.925595232873 -0.0340410744216855 0.224234177220181 -0.151810374509769 0.879336499304683 0.980703859230131 hypothetical protein I.J.1 - Repressors/activators Rv3678A - 846.2 507.8 332.3 478.6 541.2 717.1 147.773289855139 -0.098936736146405 0.276547264065888 -0.357757060011388 0.720525127619305 0.949890877982223 hypothetical protein ? Rv3679 - 480.6 333.5 250.1 432.9 463.2 437.9 656.397471746815 0.15551111507164 0.187459360151335 0.829572420102665 0.406780575506374 0.899737667944704 Probable anion transporter ATPase III.A.4 - Anions Rv3680 - 329.8 184.9 150.6 316.9 319.3 259.8 476.196671769519 0.274814804456538 0.179617684057295 1.52999859617874 0.12601707641 0.671582561030228 Probable anion transporter ATPase III.A.4 - Anions Rv3681c whiB4 145.3 83.5 59.4 113.6 105.3 58.3 52.0951914011034 -0.195308411446824 0.332444683833321 -0.587491456307199 0.556873686831759 0.92521033104044 Probable transcriptional regulatory protein WhiB-like WhiB4 I.J.1 - Repressors/activators Rv3682 ponA2 367.6 242.2 213.2 240.6 288.9 234.3 1045.94956639413 -0.295698826408112 0.184520802945976 -1.60252297674364 0.109040010790818 0.643080319504058 Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)] II.C.3 - Murein sacculus and peptidoglycan Rv3683 - 131.4 88.1 72.5 101.9 114.6 79 150.584966858655 -0.171927136966938 0.233833683673533 -0.735253938893481 0.462184854640634 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv3684 - 134.5 74.9 58.9 81.2 98 87.4 147.597992526392 -0.177948114440106 0.243720355546537 -0.730132343853931 0.465309292690998 0.901158530199572 Probable lyase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3685c cyp137 91.6 69.3 46.4 117.5 107.1 69.2 188.204358238951 0.335414950681682 0.226347069481925 1.48186124719617 0.138377218287474 0.682181933169668 Probable cytochrome P450 137 Cyp137 IV.F - Cytochrome P450 enzymes Rv3686c - 325.2 270.2 126 378.6 421.8 262 154.976149022564 0.404087680571863 0.255708441412773 1.58026726978313 0.114045672051663 0.650413049267834 hypothetical protein V - Conserved hypotheticals Rv3687c rsfB 185.7 169.9 74.7 213.2 178 138.2 93.0351707816741 0.170689006102497 0.290404186134208 0.587763586932644 0.556690988234617 0.92521033104044 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) V - Conserved hypotheticals Rv3688c - 403.7 313.9 184.7 334.8 406.5 285.4 238.443346400393 0.017786627353932 0.223668253878399 0.0795223597694914 0.936617147404644 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv3689 - 40.5 27.7 22.9 39.1 46.7 16.7 68.9756433533689 -0.00807351805010063 0.321157057573342 -0.0251388467409186 0.979944214745685 0.998567088804884 Probable conserved transmembrane protein VI - Unknowns Rv3690 - 50.2 36 40.2 37.4 47.8 43.3 45.2323326386938 -0.225289769772331 0.370896930623448 -0.607418803368466 0.543573012918743 0.92521033104044 Probable conserved membrane protein VI - Unknowns Rv3691 - 46.4 33.1 17.1 61.4 48.8 46.6 65.7762400189303 0.56610901721013 0.307857135408321 1.83886924192704 0.0659344207951006 0.514454587842348 hypothetical protein VI - Unknowns Rv3692 moxR2 64.3 36.7 22.9 63.9 40.4 73.8 85.2630180027953 0.385291665217125 0.315565426107186 1.22095652229739 0.222102481926548 0.774556499980442 Probable methanol dehydrogenase transcriptional regulatory protein MoxR2 I.J.1 - Repressors/activators Rv3693 - 44.2 22.5 20.3 50.7 54 35 77.2955500703619 0.527070255355406 0.285211734223769 1.84799639043561 0.0646028650090358 0.514454587842348 Possible conserved membrane protein V - Conserved hypotheticals Rv3694c - 108.1 63.4 43.3 98 83.9 70.2 120.902084058608 0.0978029885519635 0.246216970561129 0.397222776029899 0.691203188073778 0.942913432418385 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3695 - 53.9 34.9 23.4 61.8 49.9 37.9 63.03682620823 0.277307335373909 0.305823119723087 0.906757264215346 0.36453517378294 0.882928450686174 Possible conserved membrane protein V - Conserved hypotheticals Rv3696c glpK 23.8 26 13.2 41.5 31.8 23.5 65.2011542600084 0.46707221642613 0.331150379411104 1.41045351437235 0.158405813350722 0.708520877886452 Probable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK) I.A.1 - Carbon compounds Rv3697c vapC48 56.8 36.5 35.4 50.2 71.1 37.3 33.1051731920417 0.0897474477950072 0.402667284009434 0.222882392881227 0.823627040168088 0.967727711626973 Possible toxin VapC48 Contains PIN domain V - Conserved hypotheticals Rv3697A vapB48 86.7 80.8 48.8 124.7 138.1 126 35.7771049212651 0.67489405463979 0.389975219345998 1.73060753904212 0.0835217861441658 0.562041621739757 Possible antitoxin VapB48 ? Rv3698 - 21.9 19.6 16.1 11.6 25.9 29.1 52.6362384684665 -0.052834030607017 0.415782521674007 -0.127071312171322 0.898883956940598 0.98854987613174 hypothetical protein VI - Unknowns Rv3699 - 83 54.9 37.4 83.5 69.4 66.8 72.4738329122355 0.16144438108947 0.288845421573135 0.558930033268997 0.576209471543445 0.926626101773025 hypothetical protein IV.H - Miscellaneous transferases Rv3700c - 28.5 20.2 9.6 40.3 25.2 18 41.9408866991124 0.42229624583755 0.381623804161628 1.10657731837581 0.268476718213784 0.811591915387243 hypothetical protein IV.D - Antibiotic production and resistance Rv3701c - 83.5 45.4 39.5 111.3 71.1 56.5 101.755265996695 0.353082289679509 0.275859242695852 1.27993641332801 0.200567499924713 0.759539148751759 hypothetical protein V - Conserved hypotheticals Rv3702c - 61.3 57.2 40 60.8 52.2 42.4 59.3060908571 -0.202956387463524 0.324878377347699 -0.62471497524845 0.532158142755107 0.922852302733934 hypothetical protein V - Conserved hypotheticals Rv3703c - 68.2 50.5 23.3 85.9 55.9 41.8 107.139479354736 0.247444412735493 0.290933597050206 0.850518521217032 0.395036867655189 0.893826103932853 hypothetical protein V - Conserved hypotheticals Rv3704c gshA 78.8 52.9 39.4 75.2 51.1 28.5 110.991689909331 -0.304177980955815 0.285162057516002 -1.06668461998576 0.286114274493845 0.829758572569927 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) I.D.1 - Glutamate family Rv3705c - 62.7 30.4 46.9 40.5 50.2 35.8 46.652996039311 -0.40897349112389 0.367809613119834 -1.11191626465359 0.266174154855291 0.80816433845196 hypothetical protein VI - Unknowns Rv3705A - 24.5 7.3 15.9 18.4 22 11.5 9.32455162234121 -0.140845602518179 0.709600746356725 -0.198485702335175 0.842665070103641 NA Conserved hypothetical proline rich protein ? Rv3706c - 91 122 84.6 57.3 141.6 71.4 50.687329531848 -0.413062738431952 0.424908814876826 -0.972120897401697 0.330990407056847 0.853347384539607 Conserved hypothetical proline rich protein VI - Unknowns Rv3707c - 91.3 45.6 44.5 81.2 68.4 42.9 98.6303583719202 -0.0735359241894243 0.271036064945794 -0.271314167006267 0.786149411285578 0.963989543249515 hypothetical protein V - Conserved hypotheticals Rv3708c asd 226.3 116.6 114.2 259.4 153.3 128.4 271.14353671599 0.0728737075338794 0.235056608848256 0.310026201309337 0.756541031580204 0.959593750764785 Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase) I.D.2 - Aspartate family Rv3709c ask 382.1 245.5 188.2 284 262.9 227.4 537.893220481698 -0.244100019200484 0.175374240205824 -1.39188069418862 0.163958528900994 0.722148552452466 Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); and aspartokinase beta subunit (Ask-beta)] I.D.2 - Aspartate family Rv3710 leuA 291.1 158.7 156.3 188.5 204.7 162.8 602.701249524292 -0.29962355748762 0.184203513930366 -1.62658980328076 0.103824246388116 0.635373559341028 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS) I.D.7 - Branched amino acid family Rv3711c dnaQ 135.3 96.4 80.4 152.2 125.9 95.6 180.57888689773 0.0708093184450828 0.226394179582289 0.312770048133439 0.754455372618236 0.959593750764785 Probable DNA polymerase III (epsilon subunit) DnaQ II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3712 - 12.7 4.3 6.7 10.3 11.9 2.5 14.6866693251149 -0.129613862515822 0.60036180554681 -0.215892918767159 0.829071216951906 NA Possible ligase V - Conserved hypotheticals Rv3713 cobQ2 19.7 8.6 11.2 28.8 25 17.5 19.4907108760123 0.68146535005824 0.496131491663818 1.37355794080495 0.169578961801999 NA Possible cobyric acid synthase CobQ2 I.G.13 - Cobalamin Rv3714c - 24.5 11.2 16.5 20.4 20.8 14.3 24.8514625297439 -0.128427041330443 0.450784891550704 -0.284896507708262 0.775723431608632 NA hypothetical protein V - Conserved hypotheticals Rv3715c recR 86.8 58.6 42.4 100.3 76.9 52.4 66.2345093610254 0.137356782927769 0.305862920103049 0.449079551328066 0.653374271080141 0.939577115195416 Probable recombination protein RecR II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3716c - 136 75.5 60.9 117.8 130.2 96 64.5662071560633 0.156357833020739 0.300788785562258 0.519826005907975 0.603184851856282 0.931398768888358 hypothetical protein V - Conserved hypotheticals Rv3717 - 131.2 88.2 55.3 70.9 64.8 93 97.7100306495563 -0.440037261708197 0.289628983483907 -1.51931362812882 0.128683570985546 0.671582561030228 hypothetical protein II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3718c - 43.5 27.2 28.9 48.8 23.6 35.5 24.463701704611 -0.0614601782899395 0.465145084170745 -0.13213120031035 0.894880517980265 NA hypothetical protein VI - Unknowns Rv3719 - 134.6 78.9 67.4 89.8 114.9 119.5 228.92205207361 0.0426115376524392 0.24029107072546 0.177333005025077 0.859246827345619 0.975793048425672 hypothetical protein V - Conserved hypotheticals Rv3720 - 172.7 110 99.9 148 132.9 115.1 263.936435102129 -0.141209883682795 0.203065395784059 -0.695391172570627 0.486810191088382 0.909299509995111 Possible fatty acid synthase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3721c dnaZX 48.3 26 15.1 46.1 48.1 21.9 90.3503889003871 0.263078866838386 0.300769430112659 0.874686189816048 0.381744676404761 0.893490749801147 DNA polymerase III (subunit gamma/tau) DnaZ/X II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3722c - 206.8 98.2 115.9 117.7 139.5 104.1 274.483917250032 -0.405720799903569 0.222336267833385 -1.8248070989822 0.0680301442190917 0.520912460856883 hypothetical protein VI - Unknowns Rv3723 - 211.8 118.1 73.7 185.1 167.2 163.7 182.902288571095 0.224378784706456 0.231815121427997 0.96792126123726 0.333083695088848 0.853347384539607 Probable conserved transmembrane protein VI - Unknowns Rv3724A cut5a 68.3 43.3 32.9 90.2 83.1 19.5 20.4461369897629 0.274760513207025 0.518346351372166 0.530071278556662 0.596062511773631 NA Probable cutinase precursor [first part] Cut5a ? Rv3724B cut5b 60.7 25.6 24.9 54.5 61.6 62.5 42.1039778158831 0.48441005866927 0.368194075322831 1.31563784193035 0.188295625979341 0.739746500217031 Probable cutinase [second part] Cut5b ? Rv3725 - 120.2 61.6 59.7 110.7 100 81.4 130.217847617238 0.100807343782684 0.239764538840768 0.420443090834347 0.674161794739455 0.941521118151901 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3726 - 67 32.8 35.1 58 52.1 26.5 84.5349915732136 -0.144734160946642 0.29415991511496 -0.492025437558611 0.622701361075635 0.931582271037618 Possible dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3727 - 31.6 16.9 25.1 9.6 17.1 20 60.8522591747725 -0.960714182338129 0.39211723441843 -2.45006874988042 0.0142828940687649 0.263376566628025 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3728 - 14.4 9.5 7.4 11.3 11.8 8.8 53.2980064813863 -0.147274682078548 0.322059227964951 -0.457290676032347 0.64746213058663 0.939577115195416 Probable conserved two-domain membrane protein II.C.5 - Other membrane proteins Rv3729 - 32 27.8 22 19.5 34.9 20.5 99.863198233838 -0.354340909004776 0.307712690709077 -1.15153167127509 0.249513573459436 0.796128980119145 Possible transferase IV.H - Miscellaneous transferases Rv3730c - 17.3 11.6 8.4 16.4 8.1 13.6 20.3088417617031 -0.119609740646428 0.496135359331842 -0.241082878687602 0.809490882303095 NA hypothetical protein V - Conserved hypotheticals Rv3731 ligC 28.1 13.7 9.6 21.8 37.7 39.4 42.2472505912945 0.770236975889109 0.407917841069156 1.88821595513035 0.0589969647233439 0.499013258722963 Possible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3732 - 43.6 42.2 17.8 32 19.2 39.6 55.5275004891427 -0.366576275300587 0.375233102298048 -0.976929468790349 0.328604071465304 0.853347384539607 hypothetical protein V - Conserved hypotheticals Rv3733c - 101.2 53.8 43.8 95.6 45.4 64.3 53.160003567466 -0.0904221668625993 0.349306758517024 -0.258861773091609 0.795741893713334 0.965360560531176 hypothetical protein VI - Unknowns Rv3734c tgs2 87 56.2 36.1 53.6 73.3 59.4 132.063024861317 -0.113877283372791 0.259481693367118 -0.438864421975527 0.660759777481364 0.939577115195416 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2 V - Conserved hypotheticals Rv3735 - 79.4 45.4 42.6 61 38.5 38.9 39.6915815675257 -0.42092379555773 0.370399204533154 -1.13640577627119 0.255786779443985 0.800346416224053 hypothetical protein V - Conserved hypotheticals Rv3736 - 34.7 24.9 22.3 24.2 38.1 26.2 48.4172455476039 -0.11093916505918 0.35721141153901 -0.310570047527905 0.756127500492444 0.959593750764785 Transcriptional regulatory protein (probably AraC/XylS-family) I.J.1 - Repressors/activators Rv3737 - 54.9 33.5 18.9 62.5 62.2 34 107.88329400466 0.434223189173147 0.274143973596941 1.58392389034078 0.113211040036392 0.649247700301701 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3738c PPE66 10.1 12.7 1.8 14.6 5.8 9 12.9851015529847 0.279104983857106 0.66402182759381 0.420325013815417 0.674248039075568 NA PPE family protein PPE66 IV.C.2 - PPE family Rv3739c PPE67 21.8 4.2 13.7 22.3 4.5 19.3 4.41738024984034 -0.150332925879159 1.11591836482489 -0.134716777335903 0.892835807720615 NA PPE family protein PPE67 IV.C.2 - PPE family Rv3740c - 33.3 44 16.5 12.3 30.1 5.7 52.0865434369241 -1.1969082750653 0.451525193436421 -2.6508117209496 0.00802985903684785 0.179410603799313 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3741c - 41.9 26.6 37.6 16.4 17.7 15.9 29.5473808949951 -1.40227731670022 0.457196399298316 -3.06712239827866 0.00216130337327825 0.0776385081881511 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3742c - 66.7 70.5 30 19.6 47.5 38.6 29.7104072798891 -0.902703505147198 0.489517081729376 -1.8440694693597 0.0651730166498123 0.514454587842348 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3743c ctpJ 2.6 1.7 0.5 0.6 0 0.7 2.47504297705663 -2.53300843869619 1.51938460668153 -1.66712788029918 0.0954889793824085 NA Probable cation transporter P-type ATPase CtpJ III.A.2 - Cations Rv3744 nmtR 170.4 80.4 109 71.8 151.8 116.8 68.9341279624592 -0.316943667059989 0.3613506171106 -0.877108415074273 0.380427754406623 0.893490749801147 Metal sensor transcriptional regulator (ArsR-SmtB family) I.J.1 - Repressors/activators Rv3745c - 5.5 4 2.5 4.7 0 0 0.447151841924349 0.108177684023747 3.08893990081398 0.0350209740225897 0.972063016278777 NA hypothetical protein V - Conserved hypotheticals Rv3746c PE34 8.1 7.9 5.2 7.4 2.9 0 2.22785572167661 -1.1428736178636 1.48188637007948 -0.771228915346799 0.440571257971427 NA Probable PE family protein PE34 (PE family-related protein) IV.C.1.a - PE subfamily Rv3747 - 59.3 58.9 22 79.3 80.4 59.8 35.4368174623461 0.516309127930349 0.396328365761631 1.30273069639653 0.1926667183718 0.743258218990794 hypothetical protein V - Conserved hypotheticals Rv3748 - 44.4 23.8 17.5 60.5 35.7 56.7 21.9925147998127 0.696736553370308 0.482426790648009 1.44423271442789 0.148673525458239 NA hypothetical protein V - Conserved hypotheticals Rv3749c - 129.4 103.5 98.5 61.1 162.5 123.5 95.7614061602821 -0.185198854019956 0.363626587193729 -0.509310541479433 0.610534570128753 0.931582271037618 hypothetical protein VI - Unknowns Rv3750c - 384.4 331 283.2 156.6 474.5 411.8 223.309388266965 -0.134540125259575 0.558302953964956 -0.240980500468604 0.809570229608984 0.965980858268586 Possible excisionase IV.B.3 - Phage-related functions Rv3751 - 0.1 4 5 0 0 0 0.26083726298143 -1.01625779579024 4.02086293843537 -0.25274619188728 0.800464350465632 NA Probable integrase (fragment) IV.B.3 - Phage-related functions Rv3752c - 51.1 25.9 23.9 75.3 30.1 24.1 26.6737503182598 0.238694289267894 0.476978920948997 0.500429429445201 0.61677273548517 NA Possible cytidine/deoxycytidylate deaminase I.F.3 - 2'-deoxyribonucleotide metabolism Rv3753c - 143.1 88.7 63.3 140.6 75.8 69.2 75.8453568963331 -0.169596932087127 0.310101633751052 -0.546907573609491 0.584442232253959 0.928941202821899 hypothetical protein VI - Unknowns Rv3754 tyrA 45.6 31 25.1 26 36.6 35.2 48.369840618996 -0.305909243496589 0.354918038809411 -0.861915174902847 0.38873419777898 0.893826103932853 Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase) I.D.4 - Aromatic amino acid family Rv3755c - 382.3 229.7 155.7 234.1 340.5 247 251.924861847906 -0.0511412843952808 0.231261364446564 -0.221140632451373 0.824982933217589 0.967727711626973 hypothetical protein VI - Unknowns Rv3756c proZ 68.2 31.4 44.8 59 42.3 35.2 53.4979625992298 -0.279191848902013 0.346850109758886 -0.804935160885762 0.420857097016642 0.901158530199572 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ III.E - Adaptations and atypical conditions Rv3757c proW 105.8 74.3 60.9 128.6 99.4 72.6 98.4823077562421 0.146049413316423 0.269250109850975 0.542430283119506 0.587522122621032 0.928941202821899 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW III.E - Adaptations and atypical conditions Rv3758c proV 141.9 84.3 66.6 144.6 112.3 74.9 184.589084911736 0.0175516448695465 0.230155291279805 0.0762600102389502 0.939212240365179 0.998153412295216 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV III.E - Adaptations and atypical conditions Rv3759c proX 274.4 185 104.9 248.9 284 210.2 324.390622011707 0.254643059444994 0.210221602683872 1.21130776377879 0.225777474334608 0.77867892021138 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX III.E - Adaptations and atypical conditions Rv3760 - 59 38.3 23.8 33.7 41.8 61.9 20.7687251844676 -0.0484704671401169 0.51024388146523 -0.0949947052788322 0.924319032478545 NA Possible conserved membrane protein V - Conserved hypotheticals Rv3761c fadE36 18.4 9.8 7.2 13.8 19.6 3 18.5285902571345 -0.147131271153186 0.550893549771576 -0.267077498391828 0.789409492188005 NA Possible acyl-CoA dehydrogenase FadE36 I.A.3 - Fatty acids Rv3762c - 22.1 14.7 12.7 19.7 21.4 15.4 52.9441736559867 0.0114558388688143 0.324930516480499 0.0352562726114457 0.971875391036333 0.998153412295216 Possible hydrolase I.C.5 - Sulphur metabolism Rv3763 lpqH 513.3 308 231.7 290.4 367.6 280.5 254.262677680801 -0.326948857992469 0.214967370947215 -1.52092318267571 0.128279115554999 0.671582561030228 19 kDa lipoprotein antigen precursor LpqH II.C.1 - Lipoproteins(lppA-lpr0) Rv3764c tcrY 28.8 13.9 16.3 30.3 15.1 34.2 52.6982674688053 0.229589726767818 0.371933745801949 0.617286625263824 0.537045687094138 0.924361123608528 Possible two component sensor kinase TcrY I.J.2 - Two component systems Rv3765c tcrX 40.6 27.1 16.5 36.8 45.8 29.2 35.940409646534 0.255564111790528 0.38126538588691 0.670305045384668 0.502663351478016 0.915911629458156 Probable two component transcriptional regulatory protein TcrX I.J.2 - Two component systems Rv3766 - 56.7 41.8 23.9 27 58.6 54.6 48.1174125805881 0.0167588953525565 0.40011270120734 0.0418854370330823 0.9665900257742 0.998153412295216 Hypothetical protein VI - Unknowns Rv3767c - 86.3 71.1 28.9 86.2 76.7 62 101.489242842249 0.136951379024426 0.286184089487954 0.478542952088853 0.632263810906075 0.93413540068838 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv3768 - 26.6 14.4 19.2 14.5 23.9 28.3 12.1682077401714 -0.18174858902652 0.643532543709856 -0.282423306797773 0.777618945848397 NA hypothetical protein VI - Unknowns Rv3769 - 503.7 331.2 257.1 345.9 274.4 232.8 142.223959304228 -0.524981587578891 0.236043515015048 -2.2240881624959 0.0261425131758112 0.341085808699499 Hypothetical protein V - Conserved hypotheticals Rv3770c - 19.9 3 3.1 17.3 17.3 12.6 9.76095072431798 0.825519238595175 0.762604721013956 1.08249951232608 0.27903063197893 NA Hypothetical leucine rich protein VI - Unknowns Rv3770A - 9.8 0 8.7 7.4 10.3 2.7 1.42287061041588 -0.423842429705022 1.7346127138066 -0.244344127269136 0.806964310335185 NA Probable remnant of a transposase ? Rv3770B - 31.4 17.9 28.2 38.1 27.5 53.7 9.99952692391972 0.369156819918775 0.697498042238318 0.529258575026428 0.596626087968672 NA Probable remnant of a transposase ? Rv3771c - 19.2 14 20.8 19.8 8.9 0 7.10717064376595 -1.00606626631836 0.876375033065188 -1.14798599727284 0.250974344486405 NA hypothetical protein V - Conserved hypotheticals Rv3772 hisC2 30.1 14.8 14.6 24.8 32.9 17.5 36.7474688972953 0.124698945619713 0.382549501918367 0.325968129599926 0.744448468186899 0.956095160416489 Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase) I.D.5 - Histidine Rv3773c - 37.3 15 18.5 18.3 18.5 13.8 17.9235009038454 -0.720599970788723 0.521770833447137 -1.381066024768 0.16725866082892 NA hypothetical protein V - Conserved hypotheticals Rv3774 echA21 327.2 218.1 105.3 226.4 207.3 132.1 261.325373289388 -0.325434090672601 0.236261118247827 -1.37743397257282 0.168378115533088 0.725442161315452 Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3775 lipE 91.5 68.6 48.6 66.4 76.3 52.4 135.054045461055 -0.279476527732374 0.244552516420378 -1.14280781822732 0.253118392026615 0.796502243851669 Probable lipase LipE II.B.5 - Esterases and lipases Rv3776 - 73.7 43.2 42.3 110.5 131.3 80 195.643556986252 0.823289290781797 0.227784531805277 3.61433361719922 0.000301121117571918 0.0185089113600872 hypothetical protein V - Conserved hypotheticals Rv3777 - 75.7 50.6 34.9 50.5 35.8 36.6 74.5732131283683 -0.546922460983055 0.293119559675039 -1.86586818562838 0.062059809665032 0.513474618974024 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3778c - 88 43.2 31.7 110.5 75.2 52.3 122.208090095969 0.413563489554801 0.272575325827048 1.51724477738389 0.129204894890816 0.673033407284364 Possible aminotransferase V - Conserved hypotheticals Rv3779 - 39.8 18.5 17 29.4 30.6 25 83.3981947118069 0.0167625764860014 0.280612095757914 0.0597357588621646 0.952366091122161 0.998153412295216 Probable conserved transmembrane protein alanine and leucine rich II.C.5 - Other membrane proteins Rv3780 - 142 82.6 68.1 117 109.3 85.2 84.9550767221304 -0.0709824211327282 0.270983034687159 -0.261944151650214 0.793364499581734 0.965360560531176 hypothetical protein VI - Unknowns Rv3781 rfbE 101.1 51.3 45.6 90.5 71 71.2 92.5335621614843 0.0741301842577096 0.269347066476801 0.275221799247234 0.783145840060867 0.963989543249515 Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE II.C.5 - Other membrane proteins Rv3782 glfT1 362.4 243.2 155.4 300.6 399.4 339.8 436.693081839832 0.303800481384857 0.214220724009807 1.4181656923676 0.156142395630608 0.70782226167295 UDP-galactofuranosyl transferase GlfT1 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3783 rfbD 152 88.3 66.3 171.8 196.8 113.8 171.892224770993 0.499575809198462 0.231266558056555 2.16017314996443 0.0307592678926831 0.374802356789257 Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD II.C.5 - Other membrane proteins Rv3784 - 67 68.1 37.7 46.5 77.7 82.1 101.321995592022 0.0553234498433843 0.330836033530661 0.167223168688658 0.867194455112767 0.977876220223739 Possible dTDP-glucose 4,6-dehydratase I.C.3 - Sugar nucleotides Rv3785 - 157.1 103 65.4 141.3 109.7 85.6 186.592194042543 -0.0915808864943848 0.226052251297887 -0.405131494902483 0.685380856944177 0.942913432418385 Hypothetical protein VI - Unknowns Rv3786c - 24.4 16.2 12.9 22.8 25 11.3 35.8999041483041 -0.0218860733476217 0.383739753650697 -0.0570336357893837 0.954518401253508 0.998153412295216 hypothetical protein VI - Unknowns Rv3787c - 8.7 6.5 6 8.5 2 0 7.30892015826505 -1.00684536630982 0.886250542072052 -1.1360730611863 0.25592598827167 NA hypothetical protein V - Conserved hypotheticals Rv3788 - 10.6 6.6 3.9 13.9 23 5.8 7.20530047782703 0.895806770182211 0.811770625487182 1.10352203203287 0.269800529161437 NA Hypothetical protein VI - Unknowns Rv3789 - 15.6 17.1 13.9 11.5 8.2 5.8 6.86819064503696 -1.13563957544387 0.842194307300831 -1.34842941302169 0.177520309069059 NA GTRA family protein V - Conserved hypotheticals Rv3790 dprE1 14.9 14.3 8.4 21.2 11.8 18.8 32.9766168376201 0.286288964284888 0.41823178403932 0.684522255864639 0.493645440580614 0.913326614478915 Decaprenylphosphoryl-beta-D-ribose 2'-oxidase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3791 dprE2 35.7 34.2 22.5 60.4 60 52.8 53.4410920710239 0.737374222579533 0.336820507386656 2.18922009322033 0.0285808469015351 0.359339193316574 Decaprenylphosphoryl-D-2-keto erythro pentose reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3792 aftA 17.5 10.9 6.5 21.6 17.8 15.8 44.44045432814 0.516902746689304 0.349156387180514 1.48043331202779 0.138757645497596 0.682181933169668 Arabinofuranosyltransferase AftA II.C.5 - Other membrane proteins Rv3793 embC 43.1 21.8 24.3 50.2 44.4 38.1 191.977892582601 0.385752561291448 0.223093437591865 1.7291076127356 0.0837898369333918 0.562041621739757 Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3794 embA 38.2 20.3 16.3 49.4 48.3 40.1 181.186687050298 0.72828205504754 0.219843672834541 3.31272692844638 0.000923911394230413 0.0464643439352968 Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3795 embB 61.1 36.3 28.1 63.5 63.7 60.1 271.289590435398 0.421570988090894 0.203332992744782 2.07330341426706 0.0381440511603864 0.401181069479615 Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3796 - 46.9 28.6 19.9 26 53.2 47.7 66.2673676727235 0.232672848020939 0.357833778012272 0.650226061143282 0.515546209338989 0.915911629458156 hypothetical protein I.C.5 - Sulphur metabolism Rv3797 fadE35 28.1 31.6 11.2 14.7 21.7 13.9 57.9355891773349 -0.700096350583755 0.370936186228893 -1.88737679572666 0.0591096638673795 0.499013258722963 Probable acyl-CoA dehydrogenase FadE35 I.A.3 - Fatty acids Rv3798 - 30.7 15.6 12.7 25.8 23.8 15.3 42.7085501567748 -0.0141189864480478 0.353961430992572 -0.0398884884391375 0.968182028694972 0.998153412295216 Probable transposase IV.B.1.c - Others Rv3799c accD4 762.9 427.4 393.5 676.5 610.7 563.3 1433.2478565782 0.0596464026349576 0.165341870594093 0.360745904353453 0.718289405404525 0.949890877982223 Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase) I.H.1 - Synthesis of fatty and mycolic acids Rv3800c pks13 573 291.3 263.2 477.4 392.4 339.4 3202.81496645991 -0.0484226411718067 0.1621327534878 -0.298660450341704 0.765199136487607 0.959593750764785 Polyketide synthase Pks13 I.I - Polyketide and non-ribosomal peptide synthesis Rv3801c fadD32 544.1 345.2 333.2 375.7 413.2 329.1 1214.87535981254 -0.327384651861398 0.179378126684971 -1.82510910283036 0.0679845668008107 0.520912460856883 Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Also shown to have acyl-ACP ligase activity I.A.3 - Fatty acids Rv3802c - 234 157.5 115.7 146.7 183.4 122.3 258.978573313241 -0.342786214255613 0.212675924651663 -1.61177723720753 0.107010423233184 0.643080319504058 Probable conserved membrane protein VI - Unknowns Rv3803c fbpD 163.1 75.3 81 147.6 136.2 94.6 164.423201365737 0.0791225435206785 0.233850030070969 0.338347373727796 0.735101427490944 0.953602020109268 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3804c fbpA 1063.9 628.8 599.9 820.2 798.6 616.7 1235.17976721528 -0.224504042599395 0.167921051614834 -1.33696186654636 0.181235084607583 0.735038480974451 Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3805c aftB 122.4 75.6 53.7 135.1 115.3 91.7 292.159861613803 0.287197602831474 0.196918406221976 1.4584599192202 0.144713815122628 0.690135194188255 Possible arabinofuranosyltransferase AftB II.C.5 - Other membrane proteins Rv3806c ubiA 105.2 78 42.3 167.1 90.6 90.2 134.922680792677 0.492507800349361 0.275438552572527 1.78808592969089 0.0737621453015749 0.54162997700187 Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase) II.C.5 - Other membrane proteins Rv3807c - 119.6 89.3 43.1 167.7 110.4 76.1 77.5603206651619 0.36606306211543 0.314441595686558 1.16416869503591 0.244355654016402 0.78958848015113 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv3808c glfT2 170 111.2 82.6 166.6 142.7 128.9 406.769940308412 0.104202345422888 0.184345760054827 0.565254906822357 0.571900395191902 0.92561526805196 Bifunctional UDP-galactofuranosyl transferase GlfT2 VI - Unknowns Rv3809c glf 54.8 31.8 23.9 43.8 53.5 33.3 75.2679931499995 0.0848326452768342 0.290190138298363 0.292334693984716 0.770030734805794 0.961582398407596 UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) II.C.3 - Murein sacculus and peptidoglycan Rv3810 pirG 350.1 127.4 128.2 214.3 261.4 265.9 300.069365512657 0.191794127345401 0.250043036265481 0.767044466464426 0.443055078054691 0.901158530199572 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3811 - 180.8 102.4 89.9 134 158.1 136.1 345.448051336574 0.0304502557846012 0.20273353606391 0.150198415002253 0.880608076355367 0.980703859230131 hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3812 PE_PGRS62 40 25.7 19.2 21.1 52.9 33.9 77.5553010559536 0.161087543759496 0.353076559964873 0.456239699898294 0.648217620216349 0.939577115195416 PE-PGRS family protein PE_PGRS62 IV.C.1.b - PE_PGRS subfamily Rv3813c - 60.5 29.7 34.5 52.7 42 37.3 55.958312680172 -0.0918048077722172 0.323468314969215 -0.283813911668457 0.776552992767032 0.963013023606306 hypothetical protein V - Conserved hypotheticals Rv3814c - 66.9 28.5 29.2 50.9 60.2 49.6 58.2305157678234 0.194398814151661 0.324789751804194 0.598537401724602 0.549481410435732 0.92521033104044 Possible acyltransferase IV.H - Miscellaneous transferases Rv3815c - 80.1 34.3 51.7 75.1 78.8 51.5 73.869513970985 0.0899350771137101 0.307470086256284 0.292500250052771 0.769904168721838 0.961582398407596 Possible acyltransferase IV.H - Miscellaneous transferases Rv3816c - 133 81.5 63.1 106.7 103.6 91.1 119.127358523232 -0.0589196021258446 0.243645163720165 -0.241825453155786 0.808915415393432 0.965980858268586 Possible acyltransferase IV.H - Miscellaneous transferases Rv3817 - 17.3 17.2 7.7 20 21.5 10.5 18.0410701943552 0.140594921662918 0.521002209472947 0.269854751297784 0.787271999299377 NA Possible phosphotransferase IV.D - Antibiotic production and resistance Rv3818 - 76.3 62 36.9 59.9 81.6 64.8 158.689910116539 0.0563599639534591 0.254546003134494 0.221413666918511 0.824770351834054 0.967727711626973 hypothetical protein VI - Unknowns Rv3819 - 43.4 45.3 34.1 48.8 55.1 68.8 26.4753837845743 0.271759348535681 0.459965041121415 0.590826093811651 0.55463694941694 NA hypothetical protein VI - Unknowns Rv3820c papA2 8.6 15.9 6.8 6.7 20.6 20 30.1784078878639 0.387751752912623 0.540908246738817 0.716853098932049 0.473464743960283 0.904373078832156 Possible conserved polyketide synthase associated protein PapA2 I.I - Polyketide and non-ribosomal peptide synthesis Rv3821 - 85.3 56.1 46.7 78.5 82.8 57 76.7571783473379 0.0466361235247377 0.282738169284437 0.164944562111179 0.868987617248717 0.977876220223739 Probable conserved integral membrane protein V - Conserved hypotheticals Rv3822 - 332.1 315.1 214.8 128.7 357.2 282.3 549.826774244442 -0.357488009676943 0.508008487325407 -0.70370479745145 0.481616632077975 0.907292899730371 hypothetical protein V - Conserved hypotheticals Rv3823c mmpL8 137.4 120.3 82.8 111.4 140.2 116.1 629.633211415645 -0.0915525882474791 0.211814968709029 -0.432229076186041 0.665574928735896 0.940245605545295 Conserved integral membrane transport protein MmpL8 II.C.4 - Conserved membrane proteins Rv3824c papA1 102.8 91.4 60.5 68.1 90.3 92.9 213.03587438095 -0.21381158098863 0.260009372287581 -0.822322592095435 0.410893322014075 0.901158530199572 Conserved polyketide synthase associated protein PapA1 I.I - Polyketide and non-ribosomal peptide synthesis Rv3825c pks2 166.4 113.6 79.5 163.9 150.4 127.8 1356.1005173781 0.130753068256439 0.163032025505132 0.802008487911006 0.422548048382496 0.901158530199572 Polyketide synthase Pks2 I.I - Polyketide and non-ribosomal peptide synthesis Rv3826 fadD23 49.9 49.1 28 38.5 55.8 60 134.2694752259 0.0806552685299924 0.299293638561739 0.269485408769738 0.787556169154219 0.963989543249515 Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv3827c - 77.8 44.4 33.3 56.1 33 64.2 100.802716295246 -0.170863381690318 0.302119387711404 -0.565549212133095 0.57170026130024 0.92561526805196 Possible transposase IV.B.1.c - Others Rv3828c - 31.2 29 11.8 47.7 39.5 25.9 28.9305804326106 0.52361873129098 0.42966215091786 1.21867548764164 0.222967385154565 0.774556499980442 Possible resolvase IV.B.1.c - Others Rv3829c - 9.2 2.7 4.8 4.5 3.9 1.5 10.8409199583726 -0.96251175455153 0.683651870832931 -1.40789749229948 0.159161425766574 NA Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3830c - 9.8 4.5 3.5 5.8 4.6 6.7 5.027792061085 -0.298373332590079 0.930538086296584 -0.32064601866815 0.74847865961163 NA Transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3831 - 10.4 7.5 6.7 13.8 19.1 23.8 9.95968528493638 0.945207163506698 0.688424546680776 1.37300037900158 0.169752228876713 NA Hypothetical protein VI - Unknowns Rv3832c - 4.1 0 0 1 6.4 1.3 1.32536940674794 0.529119811262528 1.97586136289571 0.267791972250057 0.78885945033705 NA hypothetical protein VI - Unknowns Rv3833 - 13.4 14 4.8 11.6 19.3 7.7 13.7221531125022 0.118412999186881 0.605055458093266 0.195706025956761 0.844840267589189 NA Transcriptional regulatory protein (probably AraC-family) I.J.1 - Repressors/activators Rv3834c serS 10.7 3.5 3.2 10.3 2.9 2.2 9.7362772811232 -0.247466978087324 0.754369484578364 -0.328044788590089 0.742877798277384 NA SERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3835 - 66.3 37.4 47.4 46 46.7 44.4 105.987886085837 -0.367108922171446 0.279182921012685 -1.31494047286212 0.188529909183711 0.739746500217031 hypothetical protein VI - Unknowns Rv3836 - 66.2 35.7 31.2 48.9 62.7 37.4 30.4348918651322 -0.0338596605977417 0.407503509911261 -0.0830904759694343 0.933779598734802 0.998010361628995 hypothetical protein VI - Unknowns Rv3837c - 195.6 110.2 97.6 157.2 127.7 144.9 154.959120412291 -0.0847034120579901 0.234731914250062 -0.360851707483435 0.718210306354831 0.949890877982223 Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) I.B.1 - Glycolysis Rv3838c pheA 76.6 36.5 35.4 55.5 33.8 36.9 70.0296446714959 -0.381656643254972 0.307810955624075 -1.23990597566996 0.215010173384425 0.773070552038584 Prephenate dehydratase PheA I.D.4 - Aromatic amino acid family Rv3839 - 4.3 0 1.5 1.3 2.4 2.8 1.907174734224 -0.299509332252366 1.53178793648065 -0.195529240777612 0.844978648600908 NA hypothetical protein VI - Unknowns Rv3840 - 6.1 8.3 5.7 1.3 4.5 2.1 2.62280323897562 -2.54852980435118 1.44865038400643 -1.75924421274296 0.0785360376165437 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3841 bfrB 14818.5 5482.3 4878.8 4493.4 8053 7579.3 6472.64090590785 -0.354520980573217 0.264408066987211 -1.3408100010442 0.179982148291587 0.735038480974451 Bacterioferritin BfrB I.G.14 - Iron utilisation Rv3842c glpQ1 117.1 158.2 82.6 242.2 200.1 154.8 210.813412496345 0.512019426266784 0.276931898137357 1.8489001437199 0.0644722329529549 0.514454587842348 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) I.C.1 - General Rv3843c - 137.6 95.6 68.4 148 120 105.8 184.06855204304 0.14442096800158 0.219461362554716 0.658070132803321 0.510493066681095 0.915911629458156 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3844 - 23.2 13.4 10.4 21.1 16.6 23.7 13.269371319685 0.183933703740541 0.585129441154148 0.314347032987673 0.753257480099386 NA Possible transposase IV.B.1.c - Others Rv3845 - 11.7 9.2 10.7 7.1 10.6 13.8 5.71237272072739 -0.600004687977594 0.900832173983547 -0.666056014989261 0.505375297415011 NA Hypothetical protein VI - Unknowns Rv3846 sodA 117.2 100.6 59 48.4 151 182.2 112.156097975964 0.336589020838014 0.640762080422095 0.525294849870468 0.599378237042904 0.930785668439449 Superoxide dismutase [FE] SodA III.F - Detoxification Rv3847 - 175.5 116.4 59.5 179.5 155.7 116 110.900698038964 0.232338805104742 0.265899109254153 0.873785571363712 0.382235039510369 0.893712695930414 Hypothetical protein VI - Unknowns Rv3848 - 145.7 55.5 83.3 68.3 67 62.7 117.803607114437 -0.711939125048445 0.281402000723506 -2.52997179557358 0.0114071695935198 0.223774688621813 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3849 espR 400.8 379.2 194.5 349.4 403.1 366.7 224.94402658535 0.0248079311960986 0.247003226451677 0.10043565645873 0.91999846310856 0.9932884147079 ESX-1 transcriptional regulatory protein EspR VI - Unknowns Rv3850 - 74.4 74.1 35.4 86.8 91.2 49.4 71.4701147366925 0.151012764109806 0.318471719445529 0.474179510735598 0.635371903020441 0.934597866696866 hypothetical protein VI - Unknowns Rv3851 - 22.9 11.3 14.2 32.7 20.7 9.9 7.75181675716864 0.203643913141642 0.769000953804843 0.26481620358734 0.791151053744728 NA Possible membrane protein VI - Unknowns Rv3852 hns 277.6 173.4 163 194.3 312.4 197 142.932680103884 0.00206518475010099 0.265492457512967 0.00777869461696522 0.993793562251935 0.999833281786427 Possible histone-like protein Hns II.A.4 - Nucleoproteins Rv3853 rraA 96.8 57.6 32.3 103.2 122.8 66.3 57.6323151301993 0.510871393302941 0.329989007611257 1.54814670040395 0.121586980531897 0.665646250765128 Regulator of RNase E activity a RraA I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3854c ethA 542.8 409.6 256 221.9 376.9 207.3 800.076540543561 -0.761134736309536 0.229694042905677 -3.31368949181714 0.000920736943514744 0.0464643439352968 Monooxygenase EthA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3855 ethR 157.5 100 59.5 45.2 99.3 41.7 86.6199190246564 -0.934105595782409 0.334785670711582 -2.79016002625495 0.00526819957092329 0.140727431742496 Transcriptional regulatory repressor protein (TetR-family) EthR I.J.1 - Repressors/activators Rv3856c - 285.8 196.8 141.9 242.3 234.9 175.8 342.486977595308 -0.108667885169256 0.190828751240777 -0.569452372678083 0.569049183529078 0.92521033104044 hypothetical protein V - Conserved hypotheticals Rv3857c - 600.4 304.5 302.9 331.6 479 320.1 123.026624441461 -0.286865482229874 0.264644726454918 -1.08396447596979 0.278380549925578 0.82002193939739 Possible membrane protein VI - Unknowns Rv3858c gltD 243.9 120.7 131.8 214.4 188.9 161.3 413.106060516113 0.0116591108754918 0.195414720807985 0.0596634216055202 0.952423705141496 0.998153412295216 Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT) I.D.1 - Glutamate family Rv3859c gltB 251.2 141.7 138.1 209.1 214.1 186 1396.54909352489 0.0247252710403985 0.171823614319983 0.143899144120861 0.885580111546782 0.982420376752145 Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT) I.D.1 - Glutamate family Rv3860 - 22.3 21.3 12.4 29.4 6.3 27.8 37.8434382141875 0.0172333513005474 0.471279757669055 0.0365671366531492 0.970830147147955 0.998153412295216 hypothetical protein V - Conserved hypotheticals Rv3861 - 5.3 0 2.6 3.4 9.2 0 1.35531034874377 0.227641092621179 1.77073056414915 0.128557724834079 0.897707619333257 NA Hypothetical protein VI - Unknowns Rv3862c whiB6 10 3.8 0 19.6 28.8 8.1 5.40966673423225 1.84195374779531 1.00853184473695 1.82637143031981 0.067794332295123 NA Possible transcriptional regulatory protein WhiB-like WhiB6 VI - Unknowns Rv3863 - 55.7 43.1 27.3 74.7 76 52.8 101.614321406092 0.519680483415947 0.262679229431724 1.97838437603238 0.0478853609450234 0.441006936592839 Unknown alanine rich protein VI - Unknowns Rv3864 espE 270.8 184.9 161.5 206.1 269 287.1 452.774765994918 0.125329951354503 0.232914115830271 0.538095129647848 0.590511374682444 0.928941202821899 ESX-1 secretion-associated protein EspE V - Conserved hypotheticals Rv3865 espF 546.5 435.8 416 325.3 588.6 516.1 244.026398368079 -0.199001701649351 0.283631319905567 -0.701621040002237 0.482915526810476 0.907435018449577 ESX-1 secretion-associated protein EspF V - Conserved hypotheticals Rv3866 espG1 244.6 139.8 157 194 206.6 167.8 254.992266246987 -0.135637447276746 0.218870983442231 -0.61971415828424 0.535445992628287 0.923716916208796 ESX-1 secretion-associated protein EspG1 V - Conserved hypotheticals Rv3867 espH 386.1 182.3 222.2 336.7 300.4 222.5 241.575570062975 -0.0655323324360741 0.222564744855644 -0.294441657768299 0.768420438644021 0.960872935483437 ESX-1 secretion-associated protein EspH V - Conserved hypotheticals Rv3868 eccA1 344.6 195.6 218.7 237.6 222.2 223.9 675.73173203021 -0.346123348214568 0.199946095137426 -1.73108331011252 0.0834369066514085 0.562041621739757 ESX conserved component EccA1 ESX-1 type VII secretion system protein V - Conserved hypotheticals Rv3869 eccB1 787.7 542.3 456.7 513.1 633.7 515.1 1350.25755387628 -0.292134149100704 0.185712168293311 -1.57304796872174 0.115707711434411 0.652035899977573 ESX conserved component EccB1 ESX-1 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv3870 eccCa1 973.5 674.7 537.4 592.7 737.9 577.6 2488.9141661209 -0.378011867159027 0.178849208515819 -2.11357864144863 0.0345512716837382 0.390076806029468 ESX conserved component EccCa1 ESX-1 type VII secretion system protein Possible transmembrane protein V - Conserved hypotheticals Rv3871 eccCb1 648.5 443 299 414.9 447 347.8 1235.21729580906 -0.36413024114643 0.170633362880147 -2.13399205759189 0.032843430973461 0.383117660251623 ESX conserved component EccCb1 ESX-1 type VII secretion system protein V - Conserved hypotheticals Rv3872 PE35 715 498 383.6 487.1 552.8 542 257.250821620213 -0.198525240807934 0.219609084208257 -0.903993755648428 0.365998712490323 0.883373818299354 PE family-related protein PE35 IV.C.1.a - PE subfamily Rv3873 PPE68 627.1 365.4 307.1 420.1 339.8 251.9 681.861874088687 -0.530217665185633 0.179014877601969 -2.96186368579123 0.00305783128150306 0.099505427348676 PPE family protein PPE68 IV.C.2 - PPE family Rv3874 esxB 6111.3 5590.3 5007.5 3556.6 6019.1 6466.9 2790.45902301226 -0.27232007592811 0.273693541079812 -0.99498174072255 0.319745145034584 0.849868688356633 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) V - Conserved hypotheticals Rv3875 esxA 4119.9 2561 1881.1 2614.4 3197.4 2870 1326.73772820345 -0.122781329212576 0.187365935361854 -0.65530230442077 0.512273137423177 0.915911629458156 6 kDa early secretory antigenic target EsxA (ESAT-6) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3876 espI 133.4 88.3 66.1 77.4 102.3 71.3 288.981157110939 -0.373243271478614 0.212786498579012 -1.75407403181655 0.079417822647229 0.55332417491747 ESX-1 secretion-associated protein EspI Conserved proline and alanine rich protein V - Conserved hypotheticals Rv3877 eccD1 191 78.2 69.3 176 118.2 120.6 298.53649727106 0.180529280785013 0.228985636911225 0.788386919023231 0.430470419901305 0.901158530199572 ESX conserved component EccD1 ESX-1 type VII secretion system protein Probable transmembrane protein V - Conserved hypotheticals Rv3878 espJ 436.6 286.9 208.5 311.3 428.5 324.2 447.879282141566 0.0249133425276016 0.206773540358556 0.120486124503167 0.904098070613496 0.991208909356546 ESX-1 secretion-associated protein EspJ Conserved alanine rich protein VI - Unknowns Rv3879c espK 220.7 158.2 127.9 188.2 220 187.1 650.198017823443 0.0431828624694684 0.192069570823667 0.224829275581155 0.822112090436283 0.967698799911269 ESX-1 secretion-associated protein EspK Alanine and proline rich protein VI - Unknowns Rv3880c espL 255 180.1 149.3 256.4 186.9 249.8 119.574347694011 0.0612225212552767 0.26424684156532 0.231686861014545 0.816781237135723 0.967203057682185 ESX-1 secretion-associated protein EspL V - Conserved hypotheticals Rv3881c espB 379.7 304.5 223.9 340.3 379.9 328.3 731.790007302128 0.0110297249267451 0.193603983542889 0.0569705474283368 0.954568656770309 0.998153412295216 Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein V - Conserved hypotheticals Rv3882c eccE1 117.1 51.6 51.6 140.2 113.2 77.2 197.042929367724 0.433962786117129 0.233062097519614 1.86200497951241 0.0626023883475184 0.514454587842348 ESX conserved component EccE1 ESX-1 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv3883c mycP1 169.7 84.3 77.9 145.4 187.1 114.2 272.915378320403 0.268421699075192 0.217819564851359 1.23231216285995 0.217832498098786 0.773070552038584 Membrane-anchored mycosin MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1) II.B.3 - Proteins, peptides and glycopeptides Rv3884c eccA2 83.6 51.4 54.7 73.2 104.3 83 225.290717554976 0.248320468801216 0.244578484299513 1.01529972888834 0.309962973611372 0.844880251285152 ESX conserved component EccA2 ESX-2 type VII secretion system protein Probable CbxX/CfqX family protein V - Conserved hypotheticals Rv3885c eccE2 63.3 44.1 26.8 71.7 51.6 46.7 128.42247891338 0.201939937320098 0.249578846919567 0.809122807531752 0.418444510492874 0.901158530199572 ESX conserved component EccE2 ESX-2 type VII secretion system protein Possible membrane protein VI - Unknowns Rv3886c mycP2 39.7 17.8 16.9 32.8 28.4 34.2 73.4745254271669 0.19212408562864 0.301866161935108 0.636454528049889 0.524480209944377 0.920502703493749 Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2) II.B.3 - Proteins, peptides and glycopeptides Rv3887c eccD2 37.5 19 23.9 47.3 41.7 31.4 80.7545461404599 0.387799373014715 0.28756298088899 1.34857196088261 0.177474491876406 0.734764437650925 ESX conserved component EccD2 ESX-2 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv3888c - 71.7 50.6 40.4 43.5 84.2 72 100.408801566444 0.0938010779700311 0.317689628353998 0.295260120564935 0.767795178345213 0.960872935483437 Probable conserved membrane protein V - Conserved hypotheticals Rv3889c espG2 25.2 12.3 14.2 26.7 23.5 22.9 26.8128358245895 0.313375707439524 0.429311639019724 0.729949246554497 0.465421208464694 0.901158530199572 ESX-2 secretion-associated protein EspG2 VI - Unknowns Rv3890c esxC 132.4 142.4 58.9 100.7 115.3 132.6 52.6530532418617 -0.127643754416853 0.368045867482697 -0.346814801344981 0.728730456644352 0.949890877982223 ESAT-6 like protein EsxC (ESAT-6 like protein 11) VI - Unknowns Rv3891c esxD 106.4 53.5 81.9 50.8 161.2 170.9 55.1909407471271 0.433932529185735 0.454530254133734 0.954683489689251 0.339737781666464 0.855368447926409 Possible ESAT-6 like protein EsxD VI - Unknowns Rv3892c PPE69 9.8 6.5 4.8 12.3 7.4 5.3 13.9102722215804 0.11006636799648 0.580924933490317 0.189467453798512 0.84972646118722 NA PPE family protein PPE69 IV.C.2 - PPE family Rv3893c PE36 93.7 77.3 31.6 76 55.8 35.6 21.7553913439886 -0.414820000895863 0.493782941299114 -0.840085726340598 0.4008603225535 NA PE family protein PE36 IV.C.1.a - PE subfamily Rv3894c eccC2 45.6 33.9 23.1 49.9 44.4 41.9 265.932810875789 0.235585679577473 0.205916396222989 1.14408412296782 0.252588751468295 0.796502243851669 ESX conserved component EccC2 ESX-2 type VII secretion system protein Possible membrane protein II.C.5 - Other membrane proteins Rv3895c eccB2 22.5 16.6 8.2 21.8 20.6 8.6 37.1661558054825 -0.0138073982412403 0.393908313689224 -0.0350523148697332 0.972038025244506 0.998153412295216 ESX conserved component EccB2 ESX-2 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv3896c - 54.8 35.9 27.1 47.6 31.2 34.2 55.4909064243248 -0.215527016724095 0.324613505043547 -0.663949630484972 0.506722549654099 0.915911629458156 hypothetical protein IV.A - Virulence Rv3897c - 60.9 33.8 32.8 48.9 54.6 50.2 46.8978292548108 0.063704682292479 0.343321219070253 0.185554165469287 0.852794399894753 0.975712312098852 hypothetical protein V - Conserved hypotheticals Rv3898c - 99.1 73.4 39.1 60.8 70.7 48.2 34.0654956683928 -0.393514642341652 0.393625446267579 -0.999718504159277 0.31744675454171 0.847340730510678 hypothetical protein V - Conserved hypotheticals Rv3899c - 23.1 9.7 13.6 28.2 19.7 12.6 33.9335953274937 0.208137017357162 0.408188430356272 0.509904254698003 0.610118541036071 0.931582271037618 hypothetical protein V - Conserved hypotheticals Rv3900c - 81.9 35.3 45.7 81.8 94.7 66.9 99.3021195743262 0.389442789301091 0.277254262072951 1.40464130790755 0.160127966674264 0.713226981998413 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv3901c - 22.6 11.4 23.1 9.3 13.9 17.9 12.07492899552 -1.00754720672681 0.674362018123473 -1.49407466560837 0.135156104841373 NA Possible membrane protein II.C.5 - Other membrane proteins Rv3902c - 34.1 10.3 9.8 6 20.9 14.1 12.6490082298748 -0.671819641220458 0.683086742220491 -0.9835056072624 0.32535865695368 NA Hypothetical protein VI - Unknowns Rv3903c - 12.4 8.1 6.9 12 9.8 13.1 41.7954878752117 0.153628864346603 0.363572640910177 0.422553424157563 0.672621114531595 0.940710721884994 Hypothetical alanine and proline rich protein VI - Unknowns Rv3904c esxE 21.1 21.3 13.8 26.8 11.2 9.9 6.77759606863761 -0.349452394881392 0.836865554510594 -0.417572921956089 0.67625939798292 NA Putative ESAT-6 like protein EsxE (hypothetical alanine rich protein) (ESAT-6 like protein 12) VI - Unknowns Rv3905c esxF 15.5 10.9 9.4 7.1 17.2 4.5 4.50654047076241 -0.862030438448267 1.01436881524949 -0.849819538504097 0.395425425077023 NA Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13) VI - Unknowns Rv3906c - 104.3 34.2 60.4 115.9 101.3 54.6 61.6626329834751 0.275957020464653 0.346802219092329 0.795718727483648 0.426195539263042 0.901158530199572 hypothetical protein V - Conserved hypotheticals Rv3907c pcnA 54.5 34.4 32.6 69.1 65 41.1 112.49427020715 0.332555207172748 0.257520287373458 1.29137479056348 0.196573747808192 0.751109817915875 Probable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3908 mutT4 70.4 48.7 30.7 73 66.3 45 64.7070529456761 0.145438467777733 0.303686794546431 0.478909423753348 0.632003066545461 0.93413540068838 Possible mutator protein MutT4 V - Conserved hypotheticals Rv3909 - 61.2 32.8 30.8 58.6 66.4 38.1 181.749561557673 0.213933127060045 0.228876375927559 0.934710391988016 0.349937569890279 0.865921346048147 hypothetical protein V - Conserved hypotheticals Rv3910 - 95.4 62 38.8 93.7 93.4 79 431.533591923644 0.29444421568992 0.190798440559767 1.54322129062521 0.122777093244956 0.665885176304995 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3911 sigM 21.2 14.2 14.1 21.3 24.3 19.1 19.8360271895183 0.153341790790902 0.488388846470329 0.313974800815231 0.753540177729142 NA Possible alternative RNA polymerase sigma factor SigM II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3912 - 11.5 4 3.4 8 15.4 8.6 9.28445895348338 0.425769000640115 0.710287514089695 0.599431909183678 0.548884903684841 NA Hypothetical alanine rich protein VI - Unknowns Rv3913 trxB2 45.6 20 29.2 38.5 35.6 43.2 56.907082061436 0.0843928430115469 0.33946863082434 0.248602773124025 0.803668063191746 0.965592404376002 Probable thioredoxin reductase TrxB2 (TRXR) (TR) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv3914 trxC 100.4 34.7 59.7 52.9 78.2 82.7 38.0258198860604 -0.105463992707766 0.419448520621845 -0.251434890153892 0.801477895472473 0.965592404376002 Thioredoxin TrxC (TRX) (MPT46) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv3915 - 202.5 106.3 80 153.8 140.8 114.2 254.573784449099 -0.0629688480627015 0.205928310148859 -0.305780434060685 0.759771826738902 0.959593750764785 Probable peptidoglycan hydrolase II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3916c - 164.5 75.3 51.3 166.3 132.8 101.4 129.182714741753 0.347141198116413 0.264103227716827 1.31441482604151 0.188706643848395 0.739746500217031 hypothetical protein V - Conserved hypotheticals Rv3917c parB 275.7 199.9 126.7 249.5 261.1 259.1 377.977324529438 0.193018078983495 0.206527177471212 0.934589245574712 0.350000023456915 0.865921346048147 Probable chromosome partitioning protein ParB III.C - Cell division Rv3918c parA 169.2 150.3 75.6 173.7 235.4 216.5 283.978792033087 0.508364336729425 0.251469446963374 2.02157495818356 0.0432202812657089 0.418767550294889 Probable chromosome partitioning protein ParA III.C - Cell division Rv3919c gid 176.9 196.7 148.6 349.2 246.1 217.7 242.849336100085 0.391271672541178 0.260463812611243 1.50221126158962 0.13304255733395 0.680441181456551 Probable glucose-inhibited division protein B Gid III.C - Cell division Rv3920c - 440.6 364.2 260.2 923.3 690.9 634.1 491.172628691086 0.879655502897434 0.200611055951748 4.3848804779185 1.1604947941842e-05 0.0011888624447087 Conserved protein similar to jag protein V - Conserved hypotheticals Rv3921c - 440.7 391.3 254.3 517.1 619.3 624 844.206954194158 0.513087488174439 0.219635002734696 2.3360916146604 0.01948646724676 0.29134901840291 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3922c - 291.3 252.5 126.2 423.6 391.2 297.7 169.237994375327 0.577982019186314 0.241782034686463 2.39050854186014 0.0168250577622978 0.276757764055105 Possible hemolysin IV.A - Virulence Rv3923c rnpA 243 173.3 158.3 310.4 362.5 284.4 154.344506476115 0.531528281055006 0.243148127408581 2.18602662796509 0.0288136572495704 0.360627040508198 Ribonuclease P protein component RnpA (RNaseP protein) (RNase P protein) (protein C5) II.B.1 - RNA Rv3924c rpmH 264.6 155.8 78.8 247.7 280 391.7 53.1992488474259 0.754368246219632 0.372689340255358 2.02412080179904 0.0429577237768667 0.418767550294889 50S ribosomal protein L34 RpmH II.A.1 - Ribosomal protein synthesis and modification