gene wt1 wt2 wt3 ko1 ko3 DESeq2.baseMean DESeq2.log2FoldChange DESeq2.lfcSE DESeq2.stat DESeq2.pvalue DESeq2.padj annot funcat Rv0001 dnaA 100.3 114.9 71.2 106.5 74 323.874213978679 0.865696674756333 0.37084553973127 2.33438610420838 0.0195755137420269 0.0685142980970942 Chromosomal replication initiator protein DnaA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0002 dnaN 50.2 36.2 21.1 60.1 28.8 102.755163403022 1.17735014419586 0.375993512366921 3.13130441210091 0.00174031665329984 0.0098000025214436 DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0003 recF 84.8 63.7 66.3 53.4 35.2 147.48370796986 0.170991543122325 0.389101542472723 0.439452236646715 0.660333883549175 0.809588998107019 DNA replication and repair protein RecF (single-strand DNA binding protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0004 - 83.9 40.9 36 31.4 0 33.4708512025735 -1.0797681708622 0.658325928129963 -1.64017263292269 0.10096927781359 0.234430555176933 hypothetical protein V - Conserved hypotheticals Rv0005 gyrB 1184.4 859 880.7 882.2 500.2 3677.60271084231 0.41266612449215 0.293804727127181 1.40455917277844 0.1601524042891 0.32582413325215 DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0006 gyrA 716.7 441.6 450.2 306.2 105 1854.14526664199 -0.635702981308652 0.241176355873017 -2.63584288355099 0.00839285827727757 0.0349735341389614 DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0007 - 250.7 156.6 101 39.1 11.6 166.245521629451 -1.95235201427561 0.346454698121909 -5.63523030531577 1.7482454118503e-08 4.15589614011662e-07 Possible conserved membrane protein V - Conserved hypotheticals Rv0008c - 29.1 6.1 12.3 12.3 9 11.5466031276286 0.277506493954543 0.919025312842504 0.301957399950419 0.762684537883603 0.875802258232129 Possible membrane protein VI - Unknowns Rv0009 ppiA 297.6 187.1 151.7 465.8 224.6 332.975322802344 1.58761975051673 0.289001249493502 5.49347019536821 3.9411164591641e-08 8.61693487553039e-07 Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A) II.A.6 - Protein translation and modification Rv0010c - 161.6 90.7 64.8 112.7 26.8 69.111614977199 0.137129419041377 0.418391602493715 0.327753755630019 0.743097855189313 0.86306318073778 Probable conserved membrane protein VI - Unknowns Rv0011c - 299.2 170.6 148.7 429.4 118 132.524527990428 1.14537810953101 0.330323510193042 3.46744350367811 0.000525434180627442 0.00361376285006291 Probable conserved transmembrane protein VI - Unknowns Rv0012 - 80.1 70.7 46.3 82.7 29.2 96.8185399177826 0.527626925188257 0.376100560741326 1.4028878982479 0.160650270149685 0.326461994762011 Probable conserved membrane protein III.C - Cell division Rv0013 trpG 73.6 42.1 45.4 46.8 23.6 63.7945759822141 0.151252081162017 0.437255576562538 0.345912297679718 0.729408626319326 0.854071191544811 Possible anthranilate synthase component II TrpG (glutamine amidotransferase) I.G.2 - Folic acid Rv0014c pknB 190.2 147.2 77.7 40.9 17.3 303.933898356031 -1.43987117325208 0.31709339096357 -4.54084258544986 5.60298547683344e-06 7.75225568708752e-05 Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0015c pknA 193.7 143.5 106 46.9 21.3 233.196060344509 -1.33403248796334 0.318456896553746 -4.18905196401736 2.8012225594399e-05 0.000313985136251143 Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0016c pbpA 243.9 162.2 132.3 48.6 19.4 307.133270321158 -1.63035413376999 0.29466113283065 -5.53297992886969 3.14835510083438e-08 7.0135055139342e-07 Probable penicillin-binding protein PbpA II.C.3 - Murein sacculus and peptidoglycan Rv0017c rodA 139.7 78.3 61.5 51.7 13.1 165.461767670492 -0.782118300370474 0.327241069085663 -2.39003711409382 0.0168466702760107 0.0610131964392945 Probable cell division protein RodA II.C.3 - Murein sacculus and peptidoglycan Rv0018c pstP 232.2 158.3 113.4 95.7 34 352.225165873511 -0.596556020163831 0.273023607936773 -2.18499793725523 0.0288889978342129 0.0921947808332832 Phosphoserine/threonine phosphatase PstP I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0019c fhaB 429.3 312.1 185.9 408.8 107.5 255.894135583582 0.461916985890477 0.296882752068616 1.55589027207521 0.119734187006954 0.265892470456822 Conserved protein with FHA domain, FhaB V - Conserved hypotheticals Rv0020c fhaA 790.6 416.5 407.7 479.8 168.5 1352.56497916363 0.0615037754150335 0.234780871141001 0.261962463620371 0.793350381535799 0.893212667323522 Conserved protein with FHA domain, FhaA V - Conserved hypotheticals Rv0021c - 22 11.4 1.7 15 5.4 19.0925525291336 0.716211797195785 0.78722099907724 0.909797627394734 0.362929246082913 0.564225414284906 hypothetical protein V - Conserved hypotheticals Rv0022c whiB5 3.4 4.1 0 1.6 0 0.841161794096693 -0.200101331855645 2.88486842419856 -0.0693623772152573 0.944701175395841 NA Probable transcriptional regulatory protein WhiB-like WhiB5 V - Conserved hypotheticals Rv0023 - 99.9 64.4 39 16.8 2.6 53.5761984012169 -2.0645015140487 0.536885499288556 -3.84532924950374 0.000120390675193008 0.00105550438498425 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0024 - 61.5 31.1 45.7 18.8 6.8 48.4356810337015 -1.22087887594794 0.518043830958712 -2.35670961217419 0.0184376586075437 0.0654396428182718 Putative secreted protein P60-related protein IV.A - Virulence Rv0025 - 113 86.4 46.9 55.8 6.6 37.1059379084049 -0.670683392333291 0.566823319279741 -1.18323182819212 0.23671728209833 0.423033609077843 hypothetical protein V - Conserved hypotheticals Rv0026 - 55.8 29.5 25.5 20.4 7 65.5408765957732 -0.644533115857611 0.426435710832412 -1.51144263832752 0.130675712850207 0.281883906769448 hypothetical protein V - Conserved hypotheticals Rv0027 - 34.6 25.3 29.6 20.4 6.3 12.530104190643 -0.575739622786185 0.86205550509826 -0.667868390586474 0.504217606129516 0.6887538607446 hypothetical protein V - Conserved hypotheticals Rv0028 - 22.4 16.6 9.3 23.8 5.7 7.87334218281513 0.619414338663925 1.01845638512729 0.608189361576353 0.543061889580282 0.722043998833844 hypothetical protein VI - Unknowns Rv0029 - 55.3 35.7 31.2 53.8 17.6 83.4143737682246 0.562083979751763 0.380956990941926 1.47545259206819 0.140090904919778 0.296594133428484 hypothetical protein V - Conserved hypotheticals Rv0030 - 63.8 48.2 44.2 65.8 12.2 27.8531830498709 0.241264703306621 0.600011519620666 0.402100118776305 0.687610345362998 0.827240874741502 hypothetical protein VI - Unknowns Rv0031 - 19.5 10.1 10.3 13.7 2.4 3.43972369762901 -0.299052871189159 1.55593423402409 -0.192201485544619 0.847584382300961 NA Possible remnant of a transposase V - Conserved hypotheticals Rv0032 bioF2 7.8 7.4 3.7 4.4 2.6 23.5656910402059 -0.0236738562270748 0.658039580661116 -0.0359763408202441 0.971301224029258 0.988606015951619 Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) I.G.1 - Biotin Rv0033 acpA 3.9 0 1.7 3.8 0 0.563864064728586 1.38469218662391 3.65462794313048 0.37888731990535 0.704771540686704 NA Probable acyl carrier protein AcpA (ACP) I.H.1 - Synthesis of fatty and mycolic acids Rv0034 - 6.2 0 7.6 4.7 0.4 2.26731851909149 -0.319860051111373 1.97232148433757 -0.162174398875344 0.871168519641304 NA hypothetical protein VI - Unknowns Rv0035 fadD34 8.4 5.3 3 4.3 4.6 18.2745833378365 0.615945109501858 0.759924755986193 0.810534338630034 0.417633137602388 0.613290453311633 Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0036c - 81.3 47.7 40 33.8 6.5 54.7419570334337 -0.751550454006612 0.469349293687592 -1.60126043463668 0.109319248310767 0.248369760269072 hypothetical protein V - Conserved hypotheticals Rv0037c - 27.8 11.6 15.8 31.6 5.7 44.7302380200473 0.690537925602763 0.508597529312527 1.3577296109483 0.174549497292142 0.344272339275188 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0038 - 323.3 125 123.9 192.7 35.6 167.514468351963 -0.0349549467595174 0.358446304911454 -0.0975179441957205 0.922315084738144 0.963101423980692 hypothetical protein V - Conserved hypotheticals Rv0039c - 61.6 20 16.7 46.4 3 15.0883116384697 0.177024405238583 0.873710614293969 0.202612171973707 0.839438175471287 0.91350881138875 Possible conserved transmembrane protein V - Conserved hypotheticals Rv0040c mtc28 161.6 84.8 56.4 111.4 36.1 156.689557688188 0.356691397787292 0.32829585191132 1.08649376990497 0.277260595764481 0.473508693441559 Secreted proline rich protein Mtc28 (proline rich 28 kDa antigen) V - Conserved hypotheticals Rv0041 leuS 50.8 29.4 18.9 36.9 10.8 157.993582738516 0.304500160117283 0.324639890060148 0.937962861128575 0.348263496357745 0.548976103292894 Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv0042c - 169.4 113.5 86.8 56.8 2.8 86.1456544519907 -1.44033144564565 0.496742543934671 -2.89955322577539 0.00373694892388051 0.0180823402846787 Possible transcriptional regulatory protein (probably MarR-family) V - Conserved hypotheticals Rv0043c - 78.6 51.9 42.1 36.4 26.2 69.6841979786917 -0.00110836351288257 0.453978448056289 -0.002441445221966 0.998052010486563 0.999585202738999 Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0044c - 43.2 20.3 11.5 18 3.4 24.5599652319237 -0.444273974543561 0.655070114751853 -0.678208278073953 0.497639644605678 0.684221070039329 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0045c - 42.4 26.2 17.1 40.1 9.3 44.5616167045932 0.553388173946926 0.483840640634416 1.14374057793351 0.252731239658917 0.444696498197658 Possible hydrolase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0046c ino1 192.2 197.3 89 200.5 66.6 325.394934321579 0.500959108728834 0.321699318545835 1.55722775849604 0.119416420106852 0.265353174415602 myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase) V - Conserved hypotheticals Rv0047c - 200.4 223.8 120 277.2 98.8 206.94615916567 0.799793702416493 0.340615674128673 2.3480824963867 0.018870341292207 0.0666388323599174 hypothetical protein V - Conserved hypotheticals Rv0048c - 23.1 14.1 11.1 17.4 8.8 25.7159007707467 0.491594393811646 0.605228252068311 0.812246275899495 0.416650330954719 0.612100983924352 Possible membrane protein VI - Unknowns Rv0049 - 241.7 148.4 80.5 221 48.9 112.189517969604 0.528946737074842 0.373715669390167 1.41537211414759 0.156959421273884 0.321358537660171 hypothetical protein VI - Unknowns Rv0050 ponA1 190.6 140 94.6 102.1 21.2 391.332792353658 -0.550424865761238 0.292598367106893 -1.88116178228758 0.0599499147707379 0.160137705971307 Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) II.C.3 - Murein sacculus and peptidoglycan Rv0051 - 70.6 44.7 39.7 31.7 1.2 102.060252262898 -1.34567429289894 0.995767095062725 -1.35139461784904 0.176569056971084 0.347255746691605 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0052 - 76.1 31.6 41.3 16.1 3.5 30.4036698976535 -1.66911355049682 0.636206727111755 -2.62353961278316 0.00870213250348132 0.0355512725805431 hypothetical protein V - Conserved hypotheticals Rv0053 rpsF 75.8 29.8 29.2 176.1 31.2 38.3725003308658 1.86453956805903 0.541053179031439 3.44612995601803 0.00056867681102941 0.00387429792521597 30S ribosomal protein S6 RpsF II.A.1 - Ribosomal protein synthesis and modification Rv0054 ssb 141.5 98.4 84.5 183 79.4 125.596917901212 1.08370443107574 0.34743241312398 3.1191805661754 0.00181354785350738 0.0101639026853214 Single-strand binding protein Ssb (helix-destabilizing protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0055 rpsR1 145 99.8 62.9 328.8 163.1 98.2789869956207 2.17077538471065 0.385957790738886 5.62438545560868 1.86169535434191e-08 4.39608329671936e-07 30S ribosomal protein S18-1 RpsR1 II.A.1 - Ribosomal protein synthesis and modification Rv0056 rplI 164 101.5 58.2 346.8 97.3 148.165889875117 1.80094886405425 0.333964349264475 5.39263807056254 6.94307117099308e-08 1.42978826091032e-06 50S ribosomal protein L9 RplI II.A.1 - Ribosomal protein synthesis and modification Rv0057 - 121 103.4 78.9 82.8 38 87.1567434355218 0.00739712320513335 0.400792487663306 0.0184562421522917 0.98527488531735 0.995391798001726 Hypothetical protein VI - Unknowns Rv0058 dnaB 150.7 93.3 71.1 58.9 18.4 362.551264907789 -0.688279562459827 0.268536058896118 -2.56308059814822 0.0103747961283876 0.0408760043234136 Probable replicative DNA helicase DnaB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0059 - 55.1 45 26.7 8.5 1.6 29.464397480803 -2.50550259209662 0.715035833663161 -3.50402381830407 0.000458284366242217 0.00322072068498003 Hypothetical protein VI - Unknowns Rv0060 - 160.6 141.5 82.7 98.3 14.5 182.689927389339 -0.572529963546452 0.368911938238878 -1.55194208753344 0.120676081214277 0.26731374587928 hypothetical protein VI - Unknowns Rv0061c - 177.9 104.1 72.4 277.8 89.6 101.80909308899 1.41203750341251 0.357697468105623 3.94757477845931 7.89468633619723e-05 0.000732015157141639 Hypothetical protein ? Rv0062 celA1 27.3 11.7 13.9 11.8 0.8 23.1569892192665 -0.894331006638356 0.739052168620747 -1.2101053817451 0.226238458350187 0.409681298300799 Possible cellulase CelA1 (endoglucanase) (endo-1,4-beta-glucanase) (FI-cmcase) (carboxymethyl cellulase) II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv0063 - 37.6 26.4 21.5 20.9 9 63.6530412961732 -0.141653173414322 0.431727319394056 -0.328107967809722 0.742830029748264 0.86306318073778 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0064 - 130.5 76.2 66.1 130.7 62.6 584.700345881866 0.978278767882566 0.268950502264927 3.63739334801064 0.000275411172660703 0.00213463830800709 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0064A vapB1 45.7 40 21.6 56.4 19.2 16.5890579617924 0.767780467239056 0.726388049171791 1.05698389189423 0.290518939012939 0.486303441391225 Possible antitoxin VapB1 ? Rv0065 vapC1 48.8 29 32.2 64.5 35.6 38.6538926156732 1.28373281288662 0.529100641520144 2.42625450084197 0.0152555678999403 0.0561696689205703 Possible toxin VapC1 V - Conserved hypotheticals Rv0066c icd2 110.1 67.5 65.5 164.3 64.2 457.347199710696 1.2962659923115 0.265560618092825 4.88124331695296 1.05419074204865e-06 1.71281816896162e-05 Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) I.B.3 - TCA cycle Rv0067c - 42.6 36.6 18.6 20.4 0 21.3337572502064 -0.981581360287426 0.765003698926893 -1.28310668518902 0.199454701973505 0.376783229008083 Possible transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0068 - 9.1 7.6 7 5 2.2 9.44148762761398 -0.547150579793331 0.964939552992941 -0.567030937944497 0.570693162363532 0.742341234334055 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0069c sdaA 51.4 38.4 25.4 35.7 12.2 85.2942834369064 0.0875831797111907 0.384500721253469 0.227784175347371 0.819814029570702 0.904886660249121 Probable L-serine dehydratase SdaA (L-serine deaminase) (SDH) (L-SD) I.C.2 - Gluconeogenesis Rv0070c glyA2 21.5 5.9 8.6 11.6 7.1 27.581941816307 0.459055934065381 0.62659493103697 0.732619929282983 0.463790272472894 0.656310485457048 Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) I.D.3 - Serine family Rv0071 - 21 14.6 14.8 4.6 0 12.6396567232513 -2.07340951007425 0.963211976708219 -2.1525993864405 0.031350176809311 0.0982675453615747 Possible maturase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0072 - 174.4 125.7 79.6 105 41.1 208.990320641894 0.0119244060829862 0.306788181757036 0.0388685314235145 0.968995205887182 0.987109870363071 Probable glutamine-transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv0073 - 215.8 180.4 117.6 101.5 33.7 234.204892248025 -0.602568814633611 0.308857190485388 -1.95096255873673 0.0510614998541666 0.141962191902243 Probable glutamine-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv0074 - 112.3 80.1 64.8 16.7 14.5 127.648592666526 -1.62075164037468 0.430863599158187 -3.76163510573016 0.000168806196610123 0.00140026123745446 hypothetical protein V - Conserved hypotheticals Rv0075 - 91.6 74.1 39 24.6 6.1 92.7318610540166 -1.40347859994427 0.413751976404704 -3.39207708961245 0.000693649212706771 0.00458377893919288 Probable aminotransferase IV.H - Miscellaneous transferases Rv0076c - 8.9 0 11.5 30.5 2.5 6.8549674060972 1.46195913887558 1.28158325550604 1.14074456933999 0.253976233579437 NA Probable membrane protein II.C.5 - Other membrane proteins Rv0077c - 8.5 8.3 7.6 22.2 3.1 15.3312740463317 1.32965554478488 0.7794844219286 1.70581413480342 0.0880426905678318 0.212332973774288 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0078 - 6.2 2.8 1.4 4.6 2 3.68377395190307 0.969074049930499 1.47808744744124 0.655627007460277 0.512064144011729 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0078A - 409.6 267.5 208.4 276.7 71.6 268.767826369242 -0.0445975588855642 0.285354663115135 -0.156288172755635 0.875805878555804 0.93588751858224 Hypothetical protein ? Rv0078B - 1015.4 608.1 528.9 533.4 195.3 221.869880782037 -0.196013028716315 0.294851069433646 -0.664786561882987 0.506187018935368 0.690911144920645 hypothetical protein ? Rv0079 - 1501.7 628.8 793.9 781.7 249.8 1192.02703417822 -0.149264029855119 0.264872688694029 -0.563531221701544 0.573073206047822 0.743263052300572 hypothetical protein VI - Unknowns Rv0080 - 1085.4 375.9 604.6 563.2 202.5 484.359190320512 -0.0475361349138261 0.316347882521133 -0.150265380425458 0.880555245243862 0.939435746582457 hypothetical protein VI - Unknowns Rv0081 - 353 154.8 158.7 290.2 43.7 120.198418548496 0.224863648759316 0.39199172470354 0.573643866919329 0.566208820648057 0.738415274699507 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0082 - 423.9 212.3 205.8 256 88.1 212.591501488923 0.0712554087074987 0.298704053921286 0.238548515736836 0.81145569105792 0.90028507684997 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0083 - 123.2 51.4 60.7 29.6 2.8 163.607908455462 -1.64341871482067 0.420277970804761 -3.91031371849874 9.21763243409521e-05 0.000843639640350523 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0084 hycD 208.9 105.1 107.1 47.1 8 147.517730456357 -1.64118044209145 0.376437993866397 -4.35976301232209 1.30203375502761e-05 0.000163539133344248 Possible formate hydrogenlyase HycD (FHL) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0085 hycP 150.4 64.7 59.1 18.7 2.1 59.6176842859993 -2.32353517682264 0.527152244781525 -4.40771181347357 1.04468418327059e-05 0.000134555322805252 Possible hydrogenase HycP I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0086 hycQ 139.6 84.3 69.3 13.8 1.9 143.345297979547 -2.87961358698542 0.409994545608717 -7.02354121006677 2.16314307826541e-12 1.12674305635531e-10 Possible hydrogenase HycQ I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0087 hycE 111.6 79.4 53.8 10.4 5.3 126.322538737272 -2.68041425558103 0.399712675586093 -6.70585252682011 2.00233865969239e-11 8.64912625930542e-10 Possible formate hydrogenase HycE (FHL) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0088 - 312.6 240 184.7 171.8 50.1 235.96399691808 -0.439766916185182 0.301845749466319 -1.4569259860797 0.145136811993453 0.304073036187314 Possible polyketide cyclase/dehydrase VI - Unknowns Rv0089 - 44.6 40.5 20.7 58.8 19.2 43.5344047004736 0.893649668646715 0.493045605882025 1.8125091431411 0.0699075624742132 0.178492016644115 Possible methyltransferase/methylase I.G.1 - Biotin Rv0090 - 7.1 6.7 3.2 5.2 1 5.26061974515618 -0.362929738889545 1.3063705125264 -0.277815317637316 0.78115413210969 NA Possible membrane protein VI - Unknowns Rv0091 mtn 5.6 8.5 4.2 10.4 1.3 7.33004072671795 0.352310739026124 1.13802172098318 0.309581735155063 0.756879047603053 0.873502154112057 Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase) + S-adenosylhomocysteine nucleosidase (S-adenosyl-L-homocysteine homocysteinylribohydrolase) V - Conserved hypotheticals Rv0092 ctpA 28.8 11.6 9.8 25.6 6 67.9367076533385 0.672570367657884 0.433874396561135 1.55014993507024 0.121105533069721 0.267595632023052 Cation transporter P-type ATPase a CtpA III.A.2 - Cations Rv0093c - 32.3 24.4 16.8 24.4 2.3 28.1796492422863 -0.286340364665723 0.642765477538864 -0.445481866515474 0.655971561435627 0.805868918214254 Probable conserved membrane protein VI - Unknowns Rv0094c - 10.5 8.9 9.1 0 2.1 10.1733228251758 -4.19176246866553 1.39411023482634 -3.00676543644174 0.00264043419212484 0.0139172885543247 hypothetical protein IV.B.2 - REP13E12 family Rv0095c - 19.9 4.2 15.7 6.3 4.8 7.15077573631219 -0.823312349834406 1.18647639044407 -0.693913807695961 0.48773626388812 NA hypothetical protein IV.B.2 - REP13E12 family Rv0096 PPE1 3.9 3.8 1.9 16.9 13.7 33.0596567791537 3.31932637445159 0.637140459028879 5.20972468066283 1.8912105976513e-07 3.62090158750319e-06 PPE family protein PPE1 IV.C.2 - PPE family Rv0097 - 19.7 12.3 15.7 29.3 18.2 39.1459531257804 1.41649160754059 0.544174827279483 2.60300832844862 0.00924097088147719 0.0372372228238819 Possible oxidoreductase V - Conserved hypotheticals Rv0098 fcoT 20 16.4 5.8 29.1 46.3 39.492995678566 2.67919532210922 0.661408222607923 4.05074389844322 5.10550623523835e-05 0.000509045105803316 Probable fatty acyl CoA thioesterase type III FcoT VI - Unknowns Rv0099 fadD10 22 18.3 10.7 33.6 10.5 62.6893321501803 1.15169729426646 0.426285735296695 2.70170263488849 0.00689854297076337 0.0300570652135302 Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0100 - 24.3 42.4 8.1 33 42.6 18.4511251503448 1.69794326110529 0.828447561572644 2.0495482633591 0.0404085335127854 0.119650302974289 hypothetical protein VI - Unknowns Rv0101 nrp 19 14.6 8.8 5.5 0.5 118.326195614203 -1.58190431079232 0.434511745970622 -3.64064798123841 0.000271952747877093 0.00211704754501245 Probable peptide synthetase Nrp (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv0102 - 84 48.7 40 26.4 6.4 137.303898759869 -1.08853755687033 0.349427268779192 -3.1152049485817 0.00183817143125999 0.0102856290829745 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0103c ctpB 55.2 29 27.3 59.8 12.2 154.61296849816 0.631609529070951 0.336186323032374 1.87874843739592 0.0602788505858553 0.160652888468848 Probable cation-transporter P-type ATPase B CtpB III.A.2 - Cations Rv0104 - 4.5 8 3.5 4.6 1.8 12.8497788154672 -0.00998091305584818 0.867928042077832 -0.0114997010949822 0.990824768269798 0.996155108273772 hypothetical protein VI - Unknowns Rv0105c rpmB1 0.6 0 0 0 7.7 1.31703868011353 3.14942856747555 2.80446874231654 1.12300362630324 0.261435954338064 NA 50S ribosomal protein L28-1 RpmB1 II.A.1 - Ribosomal protein synthesis and modification Rv0106 - 5.5 1 3.6 34.8 14 36.1221220416334 3.63926326784392 0.588219869321502 6.18690978943252 6.13550520854127e-10 1.94035352220118e-08 hypothetical protein V - Conserved hypotheticals Rv0107c ctpI 39.7 28.7 21.7 25.7 9.1 231.544787309476 -0.029905927579739 0.294237879328273 -0.101638604954646 0.919043535782895 0.960690356564489 Probable cation-transporter ATPase I CtpI III.A.2 - Cations Rv0108c - 720.4 485.1 264.5 1737 344.2 300.162979342043 1.7528081773808 0.314353124217443 5.57592097022822 2.46223697358627e-08 5.70015905911278e-07 Hypothetical protein VI - Unknowns Rv0109 PE_PGRS1 8.4 3.4 4.3 4.7 2.5 13.3333887125016 0.22429325289646 0.824792125645862 0.271939129778701 0.785668823360609 0.886819302849992 PE-PGRS family protein PE_PGRS1 IV.C.1.b - PE_PGRS subfamily Rv0110 - 29.2 19.7 10.2 12.1 1.6 17.5456283152304 -0.712572283931466 0.755083073048928 -0.943700513711943 0.345322711433092 0.54628541487093 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0111 - 10.7 8.8 6.7 4 1 21.3383544483187 -1.15689317950206 0.702739946970934 -1.64626073199437 0.099710090361086 0.232487594610968 Possible transmembrane acyltransferase IV.H - Miscellaneous transferases Rv0112 gca 29.3 30.8 11.3 79.7 10.6 58.006287311747 1.54540504755098 0.509999121016782 3.03021119814857 0.00244382782812495 0.0131351110276458 Possible GDP-mannose 4,6-dehydratase Gca (GDP-D-mannose dehydratase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0113 gmhA 26.6 33.2 8.3 64.2 33.7 46.4216159382429 2.02436869168545 0.54525173252563 3.71272307986714 0.00020504119569474 0.00164311293020536 Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0114 gmhB 48 30.2 29.3 37.1 5.8 29.2974770447578 -0.127662405398573 0.605326713529936 -0.210898350502517 0.832966591288662 0.912296742839963 Possible D-alpha,beta-D-heptose-1,7-biphosphate phosphatase GmhB (D-glycero-D-manno-heptose 7-phosphate kinase) I.D.5 - Histidine Rv0115 hddA 24.7 30.3 8.7 7.4 1.7 27.4885263338271 -1.55525117853105 0.708851956117826 -2.19404230334456 0.0282323684794861 0.0906609693149047 Possible D-alpha-D-heptose-7-phosphate kinase HddA V - Conserved hypotheticals Rv0116c ldtA 46.6 26.6 18.4 67.9 20 54.0900084898535 1.28328209608639 0.445436470122799 2.88095425983556 0.00396473172486401 0.0189771348236059 Probable L,D-transpeptidase LdtA V - Conserved hypotheticals Rv0117 oxyS 15.9 7.3 4.2 8.4 2.1 11.2059971765842 -0.0966159660556662 0.897674214945679 -0.107629209402559 0.914289825821505 0.95801370906451 Oxidative stress response regulatory protein OxyS I.J.1 - Repressors/activators Rv0118c oxcA 49.2 18.7 33 12.8 5.9 73.8075968804368 -1.12964626920787 0.467579462893688 -2.41594500797123 0.0156944314544219 0.057368086905637 Probable oxalyl-CoA decarboxylase OxcA I.A.1 - Carbon compounds Rv0119 fadD7 10.2 11.4 5.4 4.3 0 15.8871307854382 -1.34515679518148 0.865943625754094 -1.5533999618163 0.120327612030852 0.266875642963855 Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0120c fusA2 38 23.2 22 39.4 13.3 116.999571047006 0.679847779975432 0.344191381266399 1.9752027998901 0.0482451383152952 0.136598145413889 Probable elongation factor G FusA2 (EF-G) II.A.6 - Protein translation and modification Rv0121c - 45.7 25 22.2 9.7 4.5 15.0721708474034 -1.54046094464399 0.81681039150833 -1.88594680070041 0.0593021239443989 0.158886628601408 hypothetical protein VI - Unknowns Rv0122 - 10.9 13.7 0 39.4 26.2 17.7389985855586 3.17336701019024 0.824976284488719 3.84661604200773 0.000119760422996029 0.00105258416439686 Hypothetical protein VI - Unknowns Rv0123 - 6.3 0.4 2.9 40.9 22.2 13.746256207896 4.08637686079976 0.948715491870128 4.30727325085059 1.65279384238062e-05 0.000200486157181923 hypothetical protein VI - Unknowns Rv0124 PE_PGRS2 2.6 0 3.7 2.5 3.4 9.48186414801949 1.3246396776048 1.11561162537769 1.1873663266608 0.235083156243353 0.420775448049506 PE-PGRS family protein PE_PGRS2 IV.C.1.b - PE_PGRS subfamily Rv0125 pepA 85 43 34.1 58.7 25 102.399491684706 0.464940813519993 0.366589942474948 1.26828578651409 0.204695911009496 0.384632847106437 Probable serine protease PepA (serine proteinase) (MTB32A) II.B.3 - Proteins, peptides and glycopeptides Rv0126 treS 63.8 58.2 30.6 46.7 16 147.451103124532 0.0646894829861615 0.348872811522388 0.18542426021642 0.852896281446718 0.919904717299549 Trehalose synthase TreS II.A.8 - Polysaccharides (cytoplasmic) Rv0127 mak 89.9 41.2 40.6 51.3 9.5 110.056144512889 -0.203726423986138 0.379250619246624 -0.537181519679092 0.591142235263487 0.757979835068748 Maltokinase Mak V - Conserved hypotheticals Rv0128 - 15.5 23.8 13.1 24.9 5.1 23.8928238521422 0.466267137771969 0.669705420698045 0.696227211788088 0.486286548724727 0.674139708643046 Probable conserved transmembrane protein VI - Unknowns Rv0129c fbpC 220.1 134.6 125.7 300.3 162.9 443.690281399013 1.44670010141614 0.29485923696406 4.90640929655691 9.2758854991276e-07 1.54249701586432e-05 Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0130 htdZ 7.7 6 2.4 3 0 2.20360263282044 -0.755737116647435 1.88187812784458 -0.401586641273643 0.687988262819888 NA Probable 3-hydroxyl-thioester dehydratase V - Conserved hypotheticals Rv0131c fadE1 19.3 12.8 5.4 35.1 7.9 42.7368703358769 1.56102467600471 0.509440030523431 3.06419712326261 0.00218255047582198 0.0118204797941306 Probable acyl-CoA dehydrogenase FadE1 I.A.3 - Fatty acids Rv0132c fgd2 9.1 3.2 6.3 10.6 1.8 11.3196992215157 0.575998021785294 0.899230688047595 0.640545334407902 0.521818125990354 0.704374924640942 Putative F420-dependent glucose-6-phosphate dehydrogenase Fgd2 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0133 - 104.1 70.1 34.9 21.6 13.5 50.4039795465852 -1.24774220871204 0.516967002295643 -2.4135819175524 0.0157965765207463 0.0576225273290252 GCN5-related N-acetyltransferase IV.D - Antibiotic production and resistance Rv0134 ephF 191.8 130.4 91.2 102.4 32.8 180.688503760403 -0.256433545238832 0.310125072459361 -0.82687137549137 0.408309969213708 0.604865709307802 Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv0135c - 97.6 61 41.2 144.3 29.2 85.328649685596 1.0708162390908 0.396431372988584 2.70113899164494 0.00691024536000918 0.0300689054854453 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0136 cyp138 21.3 5.2 17 48.5 20.8 70.4925927050158 2.03103590980989 0.487760940367403 4.16399867582678 3.12721927668423e-05 0.000339773333681459 Probable cytochrome P450 138 Cyp138 IV.F - Cytochrome P450 enzymes Rv0137c msrA 98.1 85 64.5 57.3 32.2 73.264018412242 -0.124264882681655 0.435165276260812 -0.285557900550821 0.775216751765781 0.881423631580758 Probable peptide methionine sulfoxide reductase MsrA (protein-methionine-S-oxide reductase) (peptide met(O) reductase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0138 - 77.3 57.9 47.9 28.4 13.5 40.9054888399315 -0.860412914206459 0.522915920069281 -1.64541349992263 0.099884567450813 0.232604298429178 hypothetical protein V - Conserved hypotheticals Rv0139 - 80.1 44 29.4 23.6 7.8 63.0730301849035 -0.943276063836466 0.444289812544902 -2.12310981976687 0.0337446503429002 0.10339407570463 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0140 - 85 55.1 61.5 79.3 24.8 45.6473844626533 0.357680566383342 0.48551949896087 0.736696604665446 0.461306872090427 0.653430085400565 hypothetical protein V - Conserved hypotheticals Rv0141c - 232.1 167.7 77.2 150.9 63.7 109.346277181557 0.289818337308556 0.381915116505665 0.7588553706914 0.44793907863978 0.642277823420826 hypothetical protein VI - Unknowns Rv0142 - 27.3 13 7.4 22.8 4.5 23.6712674944354 0.532225973182106 0.65114411542805 0.817370472329663 0.413716744692046 0.60956102732913 hypothetical protein VI - Unknowns Rv0143c - 71.7 42.1 24.7 25.2 5.3 82.1066957378513 -0.851690725588472 0.423408910340747 -2.01150874435556 0.0442717476281835 0.128217931397405 Probable conserved transmembrane protein III.A.4 - Anions Rv0144 - 757 611.3 410.2 586.4 188.3 823.974346128895 0.121615425373559 0.252821384415448 0.481032985618473 0.630493055254898 0.784685822827163 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0145 - 771.9 517.1 362.9 294.4 71.8 663.105372725355 -0.897690577907824 0.260907318617463 -3.44064927984638 0.000580320216508452 0.00393019924832301 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0146 - 171.1 109.7 87.6 46.8 2.7 125.331328328692 -1.67865064017456 0.446473362831058 -3.7598002029289 0.000170049110635478 0.00140248482738321 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0147 - 197.5 131.7 95.1 152.7 34.5 339.232991166432 0.0846856638917762 0.28372153783566 0.298481618765329 0.765335603206001 0.876096305656509 Probable aldehyde dehydrogenase (NAD+) dependent I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0148 - 267.2 164.1 198.3 214.1 142.8 374.08102997307 0.703712105683881 0.345517210512493 2.03669190498525 0.0416809262505015 0.122112357964662 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0149 - 148.2 67.2 56 159.6 68.8 204.977760694177 1.21580586126757 0.315117267107292 3.85826480544339 0.000114194885282338 0.00101278170963168 Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0150c - 1.2 0 0 3.6 0 0.415743629058934 2.15872566068642 4.13269646932891 0.522352821386121 0.601424698093119 NA hypothetical protein V - Conserved hypotheticals Rv0151c PE1 25.1 16.3 16.3 5.4 6.7 48.5446141627865 -0.76382748008463 0.580654220564335 -1.31546013622749 0.188355306334339 0.363197845810667 PE family protein PE1 IV.C.1.a - PE subfamily Rv0152c PE2 18.8 9.8 9.8 5.1 3.7 28.0813001325773 -0.769332334243211 0.634673598275162 -1.21217006085334 0.225447289398019 0.409294873935307 PE family protein PE2 IV.C.1.a - PE subfamily Rv0153c ptbB 75.9 59.5 53.1 29.4 8.3 65.6193346198706 -1.07629218539859 0.450922443520994 -2.38686763292252 0.0169926082114281 0.0613535354585917 Phosphotyrosine protein phosphatase PTPB (protein-tyrosine-phosphatase) (PTPase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0154c fadE2 106.6 64 65.1 49.2 29.7 150.509728159907 -0.137513128646077 0.364551794095789 -0.377211498813649 0.706016435598642 0.83916450164107 Probable acyl-CoA dehydrogenase FadE2 I.A.3 - Fatty acids Rv0155 pntAa 24.5 17.3 11.3 4.7 5.4 26.2574246189897 -0.995159982840585 0.695666287157054 -1.43051345337929 0.152569707374682 0.314505210733468 Probable NAD(P) transhydrogenase (subunit alpha) PntAa [first part; catalytic part] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha) I.C.1 - General Rv0156 pntAb 78.6 44.1 23 15.8 8.9 18.4093427037437 -1.26718959457129 0.757889652846188 -1.67199748645792 0.0945248177216171 0.225155954519144 Probable NAD(P) transhydrogenase (subunit alpha) PntAb [second part; integral membrane protein] (pyridine nucleotide transhydrogenase subunit alpha) (nicotinamide nucleotide transhydrogenase subunit alpha) I.C.1 - General Rv0157 pntB 100 77.9 38.9 23 6.2 115.999771526877 -1.55659727787487 0.394485227389644 -3.94589497856501 7.95024571856251e-05 0.000735242045304136 Probable NAD(P) transhydrogenase (subunit beta) PntB [integral membrane protein] (pyridine nucleotide transhydrogenase subunit beta) (nicotinamide nucleotide transhydrogenase subunit beta) I.C.1 - General Rv0157A - 119.7 101 47.5 473.5 70.4 40.7028694089428 2.27450863171712 0.544362952487896 4.1782943187481 2.93703433183401e-05 0.000323073776501741 hypothetical protein ? Rv0158 - 64 30.1 25.8 34.5 8.9 35.6466937291848 -0.156173914275898 0.539340257026949 -0.28956472698105 0.772149255153483 0.880822113286195 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0159c PE3 3.2 1.2 1.5 3.4 1.3 5.0907367223237 0.983481844274367 1.25374063027348 0.784438041271613 0.432783124195667 NA PE family protein PE3 IV.C.1.a - PE subfamily Rv0160c PE4 2 1.1 3.6 2.3 1.3 5.80608036771115 0.192917607401313 1.25876523212648 0.153259402530057 0.878193714474971 NA PE family protein PE4 IV.C.1.a - PE subfamily Rv0161 - 9.2 2.7 5.7 5.3 1.5 11.0108152395163 -0.205751641652256 0.922604202874174 -0.223011819165013 0.823526307775461 0.906045859973057 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0162c adhE1 14.2 7.5 3.7 10.1 1.7 13.5563960135828 0.167266104779809 0.837812634047023 0.199646195321543 0.84175729637543 0.91350881138875 Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0163 - 26 16.9 7.1 10.6 8.9 12.1000294722569 0.0169215955485864 0.886010162995938 0.0190986472337609 0.984762410585194 0.995391798001726 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0164 TB18.5 122.4 98.7 75.8 85.4 58.1 90.5566457988899 0.396345999110437 0.42083874644646 0.941800160886235 0.346294962798133 0.547015054800113 Conserved protein TB18.5 V - Conserved hypotheticals Rv0165c mce1R 75.6 58.8 38.3 96.4 36.7 85.0342032160717 0.98083197774126 0.38363286522196 2.55669434675201 0.0105672023524436 0.0415878119248392 Probable transcriptional regulatory protein Mce1R (probably GntR-family) I.J.1 - Repressors/activators Rv0166 fadD5 171.9 142.6 85.6 296 93.2 552.183301135789 1.28975572528236 0.266045996002035 4.84786745398903 1.24795733039455e-06 2.00921130193523e-05 Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0167 yrbE1A 183.8 148.4 61 116.2 10.2 135.842896008525 -0.501615666844555 0.457462239057581 -1.09651819104881 0.272852066973848 0.468691571882332 Conserved integral membrane protein YrbE1A IV.A - Virulence Rv0168 yrbE1B 90.7 59.4 37.7 40.7 11.9 72.3406644018936 -0.500442400346384 0.414281357287015 -1.2079771187958 0.227056063707004 0.410532198902608 Conserved integral membrane protein YrbE1B IV.A - Virulence Rv0169 mce1A 209.9 181.4 113.2 85 22.5 292.927751842136 -0.96229948129477 0.308219740557418 -3.12212150835778 0.00179552815308129 0.0100788600922566 Mce-family protein Mce1A IV.A - Virulence Rv0170 mce1B 226.1 187.1 133.8 76 23.2 236.573411424093 -1.16726462834257 0.3142257570261 -3.71473248848157 0.000203418774646209 0.00163380793604733 Mce-family protein Mce1B IV.A - Virulence Rv0171 mce1C 294.2 258.8 165 66.7 48.2 474.497360058137 -1.09903147833765 0.345716103338612 -3.17899995899586 0.00147784112080488 0.00855585318933445 Mce-family protein Mce1C IV.A - Virulence Rv0172 mce1D 279.2 179.4 142.6 50.4 15.4 354.417545311783 -1.87233620274663 0.284293962134499 -6.58591617172945 4.52088857778452e-11 1.79921206095649e-09 Mce-family protein Mce1D IV.A - Virulence Rv0173 lprK 276.1 198.8 172.7 33.4 23 286.307223419144 -2.13619433071545 0.354863425540089 -6.01976472346859 1.74670772506804e-09 5.0711793132713e-08 Possible Mce-family lipoprotein LprK (Mce-family lipoprotein Mce1E) II.C.1 - Lipoproteins(lppA-lpr0) Rv0174 mce1F 698.2 418.5 319.9 135.5 38.3 825.915023268384 -1.71577141508717 0.248325280559106 -6.90937069002439 4.86808375858214e-12 2.36202091409561e-10 Mce-family protein Mce1F IV.A - Virulence Rv0175 - 682.5 404.6 292.4 221.4 48.9 355.15958052856 -1.05709364025127 0.290645194404085 -3.63705872522218 0.000275769075394253 0.00213463830800709 Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv0176 - 286.2 226.9 163 65.6 20 252.3801326497 -1.67649091030801 0.313541041071079 -5.34695842235198 8.94445524648349e-08 1.7899017222059e-06 Probable conserved Mce associated transmembrane protein V - Conserved hypotheticals Rv0177 - 542.1 390.2 320.8 155.6 60.1 288.690909591986 -1.19446318386396 0.296845450890462 -4.02385544491541 5.72530669666384e-05 0.00056330656443287 Probable conserved Mce associated protein V - Conserved hypotheticals Rv0178 - 463 306.9 352.9 127.2 57.2 348.616224206468 -1.26533510063218 0.31967265522072 -3.95822126155434 7.55099931622208e-05 0.000707556602594143 Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv0179c lprO 156.7 82 45.5 163.5 42.4 206.197532091964 0.896735650547843 0.329127346905918 2.72458566259514 0.00643822264472785 0.0284341453960424 Possible lipoprotein LprO II.C.1 - Lipoproteins(lppA-lpr0) Rv0180c - 51.3 42.8 14.6 36.2 5.8 69.4891226456161 -0.102737635486205 0.488292217335646 -0.210401951615756 0.833353969577129 0.912438874881666 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0181c - 124.2 83.6 64.4 66.3 28.1 101.694907178731 -0.15859282255089 0.367299729536815 -0.431780395675445 0.665901029253932 0.813317739868078 hypothetical protein V - Conserved hypotheticals Rv0182c sigG 96.9 71.3 54.6 41.2 10.8 107.580123385933 -0.791263334577066 0.370371278956978 -2.13640576236198 0.0326463547817618 0.101343898893076 Probable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0183 - 109.6 83.9 43.8 27.5 11.6 80.030266197415 -1.23961671604442 0.42838717220201 -2.89368308969782 0.00380752237143437 0.0182988388597294 Possible lysophospholipase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0184 - 127.7 90.2 53.7 22.4 5.3 72.4293043672294 -1.95565054059157 0.455294609418956 -4.29535184501166 1.74416487722923e-05 0.00020853145205658 hypothetical protein V - Conserved hypotheticals Rv0185 - 97.9 83.3 58.1 20.5 0 42.899592089825 -2.21994871160598 0.629520219638039 -3.5264136756122 0.00042122845954532 0.00298996233208322 hypothetical protein V - Conserved hypotheticals Rv0186 bglS 79.1 54.7 33.5 18.8 4.7 131.097767363243 -1.4924511388652 0.365746513562505 -4.08056149142251 4.49270417107724e-05 0.000462230824819856 Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase) I.A.1 - Carbon compounds Rv0186A mymT 174.2 132.7 62 75.7 38.2 28.6033908921107 -0.278808722517936 0.603671664382058 -0.461854910489024 0.644185370394081 0.79647685134055 Metallothionein, MymT ? Rv0187 - 52.1 44.5 34.7 22.6 8.8 38.3558278526371 -0.815642677690931 0.536602287125261 -1.52001342010779 0.12850760280633 0.278734800453166 Probable O-methyltransferase IV.H - Miscellaneous transferases Rv0188 - 138.6 56.7 78.5 841.6 239.1 275.822669339897 3.28553412557238 0.308332286454226 10.6558225327471 1.63790288317012e-26 5.2740472838078e-24 Probable conserved transmembrane protein IV.H - Miscellaneous transferases Rv0189c ilvD 190.4 101.3 74 83.3 27.4 292.93925748826 -0.331678750373164 0.283923923301928 -1.1681958551286 0.242727772026527 0.430948254896219 Probable dihydroxy-acid dehydratase IlvD (dad) I.D.7 - Branched amino acid family Rv0190 - 362 279.9 166.6 67.5 48.9 95.7628288206514 -1.37911676901691 0.441152374882073 -3.12616875152393 0.0017709989478363 0.00995694964005744 hypothetical protein V - Conserved hypotheticals Rv0191 - 57.6 29.5 30.2 12.9 3.4 54.615499021408 -1.55081740981783 0.484712845227152 -3.19945597705599 0.0013768721322892 0.00811953373674459 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0192 - 151.3 114.8 69.3 53 24.5 164.197770815859 -0.729521339958455 0.341614241062213 -2.1355120843033 0.0327192041675782 0.101481104344625 hypothetical protein V - Conserved hypotheticals Rv0192A - 117.3 69.3 48.5 34.6 9.5 27.6123971147477 -1.10030754788305 0.614438133456414 -1.7907540043022 0.0733327792752984 0.184477772864423 Conserved secreted protein ? Rv0193c - 8.5 5.6 5.9 6.7 6.3 27.9166274149691 0.774641109543973 0.637059411705966 1.21596368456371 0.223998756235625 0.408296983716801 Hypothetical protein VI - Unknowns Rv0194 - 2.1 0.9 1.5 1.9 0.6 8.71291357313893 0.296356658617298 0.987261350743619 0.300180553400655 0.764039437618595 0.876096305656509 Probable transmembrane multidrug efflux pump II.C.5 - Other membrane proteins Rv0195 - 2.7 0 0 1.9 0 0.797405353204265 1.10289738676582 3.18725737495748 0.346033362549058 0.729317642056152 NA Possible two component transcriptional regulatory protein (probably LuxR-family) I.J.1 - Repressors/activators Rv0196 - 16.8 14.1 9.2 7.7 3.4 10.2228359163708 -0.70761175294018 0.936097644121022 -0.755916604837324 0.449699197678487 0.64349198451521 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0197 - 22.4 11.7 6.5 13.2 4.3 47.8751884386057 0.186886673978907 0.48490758750613 0.385406784290716 0.6999360569475 0.834176821570674 Possible oxidoreductase V - Conserved hypotheticals Rv0198c zmp1 131.6 78.6 65.8 103.9 34.6 318.528379580878 0.362069895068464 0.26839851718087 1.34900110057042 0.177336612588169 0.347992399882158 Probable zinc metalloprotease Zmp1 II.B.3 - Proteins, peptides and glycopeptides Rv0199 - 44.9 21.8 26.2 20.3 9 29.7878759723219 -0.290973908569808 0.585375647948408 -0.497072110173351 0.619138201263791 0.77682873144752 Probable conserved membrane protein V - Conserved hypotheticals Rv0200 - 101 63.8 53.8 24.7 5.7 56.8683246287674 -1.5306230866445 0.475063220982945 -3.22193556360249 0.00127327766976113 0.00763104823399987 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0201c - 122.5 88.5 39.7 67.9 19.8 60.499056576374 -0.162730600457186 0.455070046030587 -0.357594620600996 0.72064670460827 0.849224787904526 hypothetical protein V - Conserved hypotheticals Rv0202c mmpL11 151.9 87.4 64.5 72.3 21.4 410.32309483056 -0.347947987822891 0.263779106557971 -1.31908850690728 0.187139525015985 0.361619311296574 Probable conserved transmembrane transport protein MmpL11 II.C.4 - Conserved membrane proteins Rv0203 - 67.6 49.9 35.1 28.3 9.5 27.3037625708233 -0.688155964771417 0.602063041901566 -1.14299652507806 0.253040033819127 0.444797915527221 Possible exported protein VI - Unknowns Rv0204c - 39.9 16.7 21.9 26.9 8.5 52.1626062385029 0.139421423565004 0.465493626013181 0.299513066933071 0.764548603414631 0.876096305656509 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0205 - 24.7 19.8 9.5 15 3.6 27.9104778279349 -0.22071670492722 0.6033258534784 -0.365833328133886 0.71448944894913 0.84554681863609 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0206c mmpL3 310.1 203.1 157.8 169.1 65.3 966.1359952433 -0.121407551209523 0.240073442250734 -0.50571004469009 0.613060215772457 0.771837398966258 Possible conserved transmembrane transport protein MmpL3 II.C.4 - Conserved membrane proteins Rv0207c - 173.4 103.4 77.7 300 74.9 215.273844547454 1.3853147634089 0.297729578925074 4.65292957592745 3.27252038696118e-06 4.78667622164462e-05 hypothetical protein V - Conserved hypotheticals Rv0208c - 85.1 51.7 38.6 125.5 49.2 118.640008310105 1.38954032393916 0.342400659231887 4.05822911397525 4.94462449660803e-05 0.000497552839971183 Hypothetical methlytransferase (methylase) V - Conserved hypotheticals Rv0209 - 16.8 11.2 4 7.8 0 12.6707984661576 -0.668009387950076 0.936173216664182 -0.71355319299815 0.475503509748328 0.664654077162028 Hypothetical protein VI - Unknowns Rv0210 - 18.4 8.2 5.4 6.6 2.7 20.7123716061133 -0.379587913458856 0.686716471166529 -0.552757840239434 0.580429241097407 0.750047563650863 Hypothetical protein VI - Unknowns Rv0211 pckA 480.4 279.4 231.7 417.7 154.9 1133.58007966565 0.609964249188411 0.232064275509299 2.62842804154045 0.00857805018540389 0.0354119507653853 Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase) I.C.2 - Gluconeogenesis Rv0212c nadR 25 10.3 8.8 25.7 0 21.0538194974851 0.402172807608631 0.773854042431585 0.51970111359105 0.603271910631632 0.76520577719971 Possible transcriptional regulatory protein NadR (probably AsnC-family) I.J.1 - Repressors/activators Rv0213c - 7.5 5 4.3 6.1 3 13.2552733030351 0.481492132953904 0.805193705105187 0.59798298210864 0.549851288294645 0.726435383491098 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0214 fadD4 6.6 3.2 2 5 0 8.39915302268379 0.0353544696524584 1.06168451492836 0.0333003534998757 0.973435071865316 0.989924497429501 Probable fatty-acid-CoA ligase FadD4 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0215c fadE3 28.4 17.3 22.5 11.6 2.9 30.8021420562101 -1.0405137354855 0.607715529653544 -1.71217236472252 0.0868649086454717 0.210160865042528 Probable acyl-CoA dehydrogenase FadE3 I.A.3 - Fatty acids Rv0216 - 15.5 15.3 1.1 5.5 0 11.1602680561877 -1.18993614790464 1.13302042777294 -1.05023362221595 0.293610714775621 0.489419195946797 Double hotdog hydratase V - Conserved hypotheticals Rv0217c lipW 18 6.9 5.9 6.7 2.2 11.4797675905841 -0.533391065256179 0.890888353696489 -0.598718192962141 0.549360823131331 0.726392246777547 Possible esterase LipW II.B.5 - Esterases and lipases Rv0218 - 7.9 0 0 3.7 3 7.85665289222762 1.74756708277414 2.48988917589463 0.701865408184774 0.482763103299536 0.670830487205554 Probable conserved transmembrane protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0219 - 6.3 0 2.2 4.9 3.6 3.26032125620119 1.3420874011388 1.63296096585749 0.821873534762694 0.41114887674586 NA Probable conserved transmembrane protein VI - Unknowns Rv0220 lipC 460.3 341.9 239.7 143.3 48.5 523.391031211616 -1.10743332785222 0.26463648084434 -4.18473418448917 2.8549998579452e-05 0.000315028333234951 Probable esterase LipC II.B.5 - Esterases and lipases Rv0221 - 172.3 146.9 87.2 74.9 20 248.600750843976 -0.818110300768538 0.315737430009199 -2.59110964685024 0.00956670052593346 0.0382452068429529 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv0222 echA1 140.6 76.2 56.2 45.3 5.5 81.4833392270011 -1.147097515488 0.454711848454664 -2.52269106113335 0.0116460665496736 0.0451353356669073 Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0223c - 22.9 10.2 10.5 22.8 10.5 47.4814165132507 1.04951541190168 0.479400593339185 2.18922426564276 0.0285805437860607 0.0914474129089676 Probable aldehyde dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0224c - 8.6 9.8 4.2 9.4 5.5 11.8186479935165 0.739829658197663 0.866988405593514 0.853332816707275 0.393474766445094 0.593853153515779 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0225 - 76.8 60.1 32.4 22.3 8.5 80.142951938939 -1.10698458766217 0.421062679804454 -2.62902565522136 0.00856299005561813 0.0354119507653853 Possible conserved protein II.C.5 - Other membrane proteins Rv0226c - 16.8 11.9 5.2 4.6 0 20.1150460390772 -1.48944911888073 0.793457925828094 -1.87716206543184 0.0604958849830772 0.160989049293809 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0227c - 88.6 73.4 53.5 40.2 36.2 154.501370132098 0.0742440408235863 0.412282970064773 0.180080299731813 0.85708952830821 0.922738938987137 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0228 - 16 12.7 7.6 4.7 0 15.825628874423 -1.58683353439746 0.859216559890871 -1.8468376989836 0.0647706663025295 0.168689485326147 Probable integral membrane acyltransferase IV.H - Miscellaneous transferases Rv0229c - 597.3 380.8 257.6 348 109.9 423.429209229128 -0.0727782687317429 0.262117459292807 -0.277655173860218 0.781277074052171 0.885336132396263 Possible conserved membrane protein with PIN domain V - Conserved hypotheticals Rv0230c php 163.3 82.6 66.4 318.8 68.5 274.266625653252 1.57863967686072 0.301226110518227 5.24071327729471 1.59957091981162e-07 3.07917402063737e-06 Probable phosphotriesterase Php (parathion hydrolase) (PTE) (aryldialkylphosphatase) (paraoxonase) (a-esterase) (aryltriphosphatase) (paraoxon hydrolase) V - Conserved hypotheticals Rv0231 fadE4 13.5 12.1 7.3 22.5 9.8 49.3045297748717 1.37877573476874 0.475985970856594 2.89667305170249 0.00377142574806701 0.0181499864125725 Probable acyl-CoA dehydrogenase FadE4 I.A.3 - Fatty acids Rv0232 - 331.6 170.5 128.1 804.7 186.1 464.310306878125 1.94317182484478 0.276118099522236 7.03746631679353 1.95766838683141e-12 1.03493454121744e-10 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv0233 nrdB 301.5 138.4 133.2 949.7 236.7 722.142909087436 2.34588315885558 0.260533974768788 9.00413529919637 2.17371984427476e-19 3.20804820350884e-17 Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0234c gabD1 61.9 39.9 20.2 39.4 5.1 85.175768517353 -0.209149002178155 0.447714266060365 -0.467148398058765 0.640393709541057 0.793102978739309 Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 I.A.1 - Carbon compounds Rv0235c - 22.5 23.3 7.3 8.5 6.7 38.170544429808 -0.318696430076721 0.604478839221026 -0.527225122532686 0.598037264649835 0.761959709132992 Probable conserved transmembrane protein V - Conserved hypotheticals Rv0236c aftD 53.2 31.9 19.9 6.1 1.2 147.805071880676 -2.47969394930061 0.386902994288215 -6.40908441110025 1.46396128565234e-10 5.23772815533393e-09 Possible arabinofuranosyltransferase AftD II.C.5 - Other membrane proteins Rv0236A - 433.1 253.9 127 235.1 103.7 75.3641600662131 0.192035951205355 0.425436288219931 0.451385921988115 0.651711427963465 0.802629303840957 Small secreted protein ? Rv0237 lpqI 40 26.2 15.9 16.5 5.1 42.0523568394794 -0.546480888245096 0.505725996958791 -1.08058690186264 0.279880911498105 0.476375871468664 Probable conserved lipoprotein LpqI II.C.1 - Lipoproteins(lppA-lpr0) Rv0238 - 400.4 294.4 252.9 182.2 115.9 304.474958498648 -0.173556483154993 0.333573554088108 -0.520294492857641 0.602858333700355 0.76520577719971 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv0239 vapB24 1065.9 741.8 505.3 937.5 130.1 277.642092465025 0.037269666579061 0.344099920937901 0.108310593264527 0.9137493198421 0.95801370906451 Possible antitoxin VapB24 V - Conserved hypotheticals Rv0240 vapC24 96.7 37.3 21.4 62.4 25.3 39.8618057659692 0.647456914906588 0.544565902585571 1.18894134177791 0.234462750261985 0.420276852949367 Possible toxin VapC24 Contains PIN domain VI - Unknowns Rv0241c htdX 491.1 279.4 302.5 171.7 66.6 399.20352775013 -0.814862100832453 0.284233568560529 -2.86687496117801 0.00414546762084504 0.0197090554537358 Probable 3-hydroxyacyl-thioester dehydratase HtdX VI - Unknowns Rv0242c fabG4 477.3 279.6 225.1 165.8 58.7 580.649188723025 -0.754504214571352 0.250238531109398 -3.01514003949097 0.00256860629205991 0.0136401851371457 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG4 (3-ketoacyl-acyl carrier protein reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv0243 fadA2 1188.2 676 575.3 377.7 90.4 1306.93627188224 -1.10931875484745 0.244514718050593 -4.53681792119328 5.71093717553963e-06 7.87087139134684e-05 Probable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) I.A.3 - Fatty acids Rv0244c fadE5 83.7 38.9 29 25.7 8.5 115.687571589946 -0.750443095149997 0.369024602060565 -2.03358554134239 0.0419934008466948 0.122824629066055 Probable acyl-CoA dehydrogenase FadE5 I.A.3 - Fatty acids Rv0245 - 105.1 61.5 39.3 92.4 53.7 74.4015310369565 1.0094331701001 0.428325764519617 2.35669495910948 0.0184383860905238 0.0654396428182718 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0246 - 22.1 12 4.6 19.6 17.4 47.9704495204487 1.61106595917806 0.563656780446876 2.85823929573024 0.00425999001619641 0.0201453733476204 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0247c - 517.8 415.7 332.1 119.8 84.6 405.919750246694 -1.12760799872098 0.342821653475469 -3.28919713002222 0.00100473626162898 0.00619995790712517 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0248c - 314.7 220.8 200.3 87.4 49.6 624.045818951206 -0.958426691759602 0.300063648378043 -3.19407797958952 0.00140278219892996 0.00822624925266541 Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0249c - 347.1 228 182.7 215.4 72.7 322.524029692168 -0.0522369365575874 0.271360087794935 -0.192500440953065 0.847350222539454 0.91718647671135 Probable succinate dehydrogenase [membrane anchor subunit] (succinic dehydrogenase) II.C.5 - Other membrane proteins Rv0250c - 1130.3 903.6 559.8 1116.3 564.3 536.133526426788 0.859346037716501 0.290431848202262 2.95885607255454 0.00308783281104262 0.0155814900768308 hypothetical protein VI - Unknowns Rv0251c hsp 15.8 7.4 8.9 29.2 11.5 14.516385353995 1.69909674302781 0.773939221474976 2.19538782359378 0.028135789815221 0.0904328198961097 Heat shock protein Hsp (heat-stress-induced ribosome-binding protein A) III.B - Chaperones/Heat shock Rv0252 nirB 208 46.4 167.9 125.8 46.5 591.307586518897 0.0505965549754855 0.747575769557491 0.0676808385662832 0.9460397029391 0.976108861086856 Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB I.B.6.b - anaerobic Rv0253 nirD 98.4 14.4 73.8 40.1 24.8 35.2226593556818 -0.175354817500994 0.664122811526107 -0.264039744543695 0.791749293405169 0.892260896354155 Probable nitrite reductase [NAD(P)H] small subunit NirD I.B.6.b - anaerobic Rv0254c cobU 23.9 18.1 3.2 13.5 0.1 9.11024777931756 -0.372457523773752 1.10392607547712 -0.337393537527207 0.735820255665353 0.858772482744039 Probable bifunctional cobalamin biosynthesis protein CobU: cobinamide kinase + cobinamide phosphate guanylyltransferase I.G.13 - Cobalamin Rv0255c cobQ1 23.5 6.5 13.5 6.5 4.3 29.5845250992078 -0.672279266000984 0.645192698420134 -1.04198213595283 0.297419961292103 0.493333637261146 Probable cobyric acid synthase CobQ1 I.G.13 - Cobalamin Rv0256c PPE2 15.5 7.4 7.4 8.3 5.9 30.2587883769063 0.353960559658789 0.596887863126176 0.59301014734147 0.553174361291415 0.729149825588738 PPE family protein PPE2 IV.C.2 - PPE family Rv0257 - 20.3 26.6 4.7 19.4 11.3 11.9257738128575 0.710009134733269 0.913579242756803 0.77717301521733 0.437056700572827 0.631859115685287 hypothetical protein ? Rv0258c - 12.6 3.8 1.1 10.9 0 3.31683323717964 0.849838787086776 1.72711116253907 0.492057955225885 0.622678373826382 NA hypothetical protein V - Conserved hypotheticals Rv0259c - 11 6.9 4.2 6.6 2.7 7.40079537890019 0.0857982029998165 1.05640637290123 0.0812170441230744 0.935269345043494 0.97175829279673 hypothetical protein V - Conserved hypotheticals Rv0260c - 12.6 4.5 7.1 10.4 5.2 18.9710522081932 0.758762819481245 0.701696486736127 1.08132623409668 0.279552021779546 0.476044837088053 Possible transcriptional regulatory protein I.J.2 - Two component systems Rv0261c narK3 4.6 3.7 4.9 2.4 2.8 11.117757955808 -0.0729659744967754 0.958258754285344 -0.0761443338456035 0.939304269190011 0.973096145501906 Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator) III.A.4 - Anions Rv0262c aac 57.3 30.8 37.4 24.7 9.5 31.4874856663815 -0.575445280850261 0.573203537892291 -1.00391090216612 0.315421561172088 0.513193922678702 Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC) IV.D - Antibiotic production and resistance Rv0263c - 60.7 51.4 30.5 18.8 4.6 50.0911406146116 -1.30115795422475 0.502243245450729 -2.59069278882397 0.0095782954778949 0.0382483907358554 hypothetical protein V - Conserved hypotheticals Rv0264c - 35.2 30.2 15.6 16.4 0 19.4263954887253 -1.0026286830218 0.788037447768694 -1.27231096169442 0.203262655388018 0.382955492225724 hypothetical protein V - Conserved hypotheticals Rv0265c - 103.8 79.9 47.1 36.7 7.2 91.7122286781394 -1.07622788832033 0.409074920373674 -2.63088210672324 0.00851635731238731 0.0352969062149155 Probable periplasmic iron-transport lipoprotein III.A.2 - Cations Rv0266c oplA 13.7 9.5 7.7 8.9 1.6 53.033900470286 -0.265734150305866 0.468934044020392 -0.566677027813126 0.570933631064503 0.742381395459056 Probable 5-oxoprolinase OplA (5-oxo-L-prolinase) (pyroglutamase) (5-OPASE) V - Conserved hypotheticals Rv0267 narU 1.9 0 0 1.2 1.4 2.37267206107174 1.59724777136669 2.0062091643212 0.796152165872059 0.425943596561445 NA Probable integral membrane nitrite extrusion protein NarU (nitrite facilitator) III.A.4 - Anions Rv0268c - 88.7 47.7 44.9 313.3 56.8 115.197482197663 2.25448025577996 0.37694444623155 5.98093506435447 2.21860312227046e-09 6.3373324670016e-08 Hypothetical protein VI - Unknowns Rv0269c - 24 12.6 5.4 9.9 0 18.3863723558066 -0.747335424481671 0.817831374695319 -0.913801362487577 0.36082123039259 0.56201794109523 hypothetical protein V - Conserved hypotheticals Rv0270 fadD2 471.7 338.5 208.7 384.3 113.8 967.565970013613 0.292411644074675 0.246744230886365 1.18507996326504 0.23598583240011 0.422152433515753 Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0271c fadE6 76.4 37.7 43.6 47.7 18.1 187.811277155412 0.0998912546918555 0.318112131203815 0.314012717194538 0.753511380021236 0.870778893323073 Probable acyl-CoA dehydrogenase FadE6 I.A.3 - Fatty acids Rv0272c - 68.6 49.9 44.6 55.8 17.6 102.097643013645 0.139864211744871 0.367780437092594 0.380292689982469 0.703728161191845 0.837568933784111 hypothetical protein VI - Unknowns Rv0273c - 68.5 44.4 36.2 70.5 45.8 74.9747028594905 1.15858372538292 0.432976959116578 2.67585537980318 0.00745388014894558 0.0320093707937713 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0274 - 101.4 70.3 33.8 130.5 23.3 76.606541861299 0.864292226451036 0.431238840297189 2.00420775145255 0.0450478105801009 0.129828596480649 hypothetical protein VI - Unknowns Rv0275c - 297.7 154 102.5 267.6 102.9 269.242543609982 0.868169249194033 0.296331756822334 2.92972058919269 0.00339266915276489 0.01673653779818 Possible transcriptional regulatory protein (possibly TetR-family) I.A.3 - Fatty acids Rv0276 - 223 123.7 86.5 441.9 154.1 416.599167115815 1.8643092493621 0.264766075982763 7.04134486430003 1.90393119261193e-12 1.02177640670173e-10 hypothetical protein V - Conserved hypotheticals Rv0277c vapC25 272.8 152.3 144.3 179.7 120.9 158.848991424344 0.597026475188231 0.365788604524913 1.63216258736012 0.102645239858764 0.237162061043538 Possible toxin VapC25 Contains PIN domain V - Conserved hypotheticals Rv0278c PE_PGRS3 5.5 1.9 3 3.5 2.1 18.9323981267634 0.53082364531861 0.715812509982038 0.741567991500917 0.458349122843824 0.652258976742798 PE-PGRS family protein PE_PGRS3 IV.C.1.b - PE_PGRS subfamily Rv0279c PE_PGRS4 26 7.4 7.1 16 1.6 46.0610964395907 0.0880346257860907 0.572632294271181 0.153736746367295 0.877817309783138 0.937361745930623 PE-PGRS family protein PE_PGRS4 IV.C.1.b - PE_PGRS subfamily Rv0280 PPE3 203.5 122.2 101 715.1 870.7 2147.82351241842 3.75773921943237 0.674630871899715 5.57006709291384 2.54641259112775e-08 5.85674895959383e-07 PPE family protein PPE3 IV.C.2 - PPE family Rv0281 - 169.5 94.9 69.8 226.3 122.2 284.343412831363 1.59119372803143 0.310449658212374 5.12544847752069 2.96830332262293e-07 5.3369189688987e-06 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0282 eccA3 577.4 442.8 328.1 608.4 388.5 2023.57007213818 1.13973256581713 0.29857213974995 3.81727701309183 0.000134932644396861 0.00116002773411088 ESX conserved component EccA3 ESX-3 type VII secretion system protein V - Conserved hypotheticals Rv0283 eccB3 232.3 134.3 120.3 159 63.5 446.823326349131 0.270942005016772 0.261986075984365 1.03418475199019 0.301049801087089 0.497349997878018 ESX conserved component EccB3 ESX-3 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv0284 eccC3 222.2 152.3 129.6 85.3 66.4 1050.27024658057 -0.0949647042896002 0.33020325893249 -0.287594691211136 0.77365700907577 0.881423631580758 ESX conserved component EccC3 ESX-3 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv0285 PE5 229 147.1 117.8 92.9 47 72.9082151454724 -0.432596822012971 0.420323012506295 -1.02920089821751 0.303385280329381 0.499819605717656 PE family protein PE5 IV.C.1.a - PE subfamily Rv0286 PPE4 219.7 136.6 134.4 59.3 51.3 358.756893433853 -0.546088673416736 0.366795917638489 -1.48880793693826 0.136537951701669 0.290635471711125 PPE family protein PPE4 IV.C.2 - PPE family Rv0287 esxG 510.5 322.6 285 249.1 165.1 182.264636599136 0.0799534723649279 0.358235840222567 0.223186692641512 0.823390208480661 0.906045859973057 ESAT-6 like protein EsxG (conserved protein TB9.8) V - Conserved hypotheticals Rv0288 esxH 1017.5 692.7 574.5 393.1 407.2 379.93865339057 0.204648881318577 0.38929061173562 0.525696934755675 0.59909879388546 0.76276345360974 Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4) V - Conserved hypotheticals Rv0289 espG3 396.2 220.3 161.7 125.7 72 319.319634713348 -0.450238147095364 0.314457819807577 -1.43179186121329 0.152203397195916 0.314163422417211 ESX-3 secretion-associated protein EspG3 V - Conserved hypotheticals Rv0290 eccD3 173.6 106.7 65.4 29.5 11.7 181.752124820999 -1.67118422670508 0.340610749879147 -4.90643418417663 9.27470913039037e-07 1.54249701586432e-05 ESX conserved component EccD3 ESX-3 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv0291 mycP3 335.1 189.1 176.9 59.1 20.5 363.859166639247 -1.7864660760597 0.283990015905402 -6.2905946547599 3.16252141285125e-10 1.03814689247123e-08 Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) II.C.5 - Other membrane proteins Rv0292 eccE3 136.9 74.8 53.4 18.3 4.4 90.05424483162 -2.20908616994461 0.43071026921098 -5.12893777525074 2.91381627899625e-07 5.27727430541885e-06 ESX conserved component EccE3 ESX-3 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv0293c - 112.5 60.8 47.6 91.4 16.6 139.643727313851 0.226498893154034 0.356887831234721 0.634650087032717 0.525656653623772 0.706862515996735 hypothetical protein V - Conserved hypotheticals Rv0294 tam 4 6.3 1.4 3.1 0 3.21938426050039 -0.465529491709755 1.65438434943678 -0.28139137792753 0.778410230488258 NA Probable trans-aconitate methyltransferase Tam V - Conserved hypotheticals Rv0295c - 54.5 24.3 29.5 31.9 2.5 36.6984401670289 -0.470236188663792 0.60687216587268 -0.774852127198146 0.438427043036475 0.633211846321845 hypothetical protein VI - Unknowns Rv0296c - 12.7 15.3 5.4 16.5 8.5 35.4262238208236 1.07290866542415 0.572721001752226 1.87335310236854 0.0610196415109514 0.161775127419004 Probable sulfatase I.C.5 - Sulphur metabolism Rv0297 PE_PGRS5 85.6 52.4 35.5 103.4 13.3 183.826220637559 0.61174611861948 0.367874454999347 1.66292089680586 0.0963282708182098 0.227766845953337 PE-PGRS family protein PE_PGRS5 IV.C.1.b - PE_PGRS subfamily Rv0298 - 1207.3 637.8 501.4 680.5 170.2 258.060930292751 -0.145588418568698 0.294259715695 -0.494761636756287 0.62076838731952 0.77859831015784 Hypothetical protein VI - Unknowns Rv0299 - 766.5 468.8 346 297.3 110 215.761482216098 -0.576824222851464 0.300134713893628 -1.9218843944053 0.0546203058766636 0.149740807596859 Hypothetical protein VI - Unknowns Rv0300 vapB2 864.6 525.9 337.9 462 113.2 179.506094929658 -0.254992626361991 0.322435240685527 -0.790833613037624 0.429041092337219 0.623393457326405 Possible antitoxin VapB2 VI - Unknowns Rv0301 vapC2 630 431.5 378.6 211.9 57.7 253.280763885862 -1.13752404553257 0.304098920237648 -3.74063822602072 0.000183553565941042 0.00150149360407198 Possible toxin VapC2 V - Conserved hypotheticals Rv0302 - 140.8 84.6 68.3 56.6 29.7 89.3947897779831 -0.38723736784241 0.393562760484531 -0.98392786798646 0.325150980306348 0.524685545441952 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv0303 - 52.5 43.8 38.5 7.9 3.2 45.0597544972267 -2.39494729021363 0.563606072451463 -4.24932840023628 2.14412387562611e-05 0.000247377419135755 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0304c PPE5 9.1 8.3 6.6 6.1 2.4 83.0702898278767 -0.178839699649704 0.410347954836983 -0.435824518050176 0.662964053579102 0.811587316217242 PPE family protein PPE5 IV.C.2 - PPE family Rv0305c PPE6 14.1 8.9 8.6 22.8 12.4 90.4491827581852 1.61898753681627 0.398691726664021 4.06075027029741 4.89152711661964e-05 0.000493612223563156 PPE family protein PPE6 IV.C.2 - PPE family Rv0306 - 2.6 2.6 1.6 3.3 0 1.80090573772509 0.649896307066679 2.02956280300127 0.320214928114384 0.748805407524797 NA Putative oxidoreductase I.G.13 - Cobalamin Rv0307c - 15 12.3 6.7 13.6 6.1 9.66999549564211 0.536144584181474 0.924954962360455 0.57964398916597 0.562154722006354 0.73610156192777 hypothetical protein VI - Unknowns Rv0308 - 91.8 57 40.1 71.1 15.2 70.7937571969513 0.184683980658776 0.41511028853378 0.444903404613513 0.656389562125387 0.805868918214254 Probable conserved integral membrane protein V - Conserved hypotheticals Rv0309 - 239.8 98.9 103.4 144.6 45.6 152.752358297597 0.15699492054739 0.334730656703392 0.469018649482423 0.639056305684957 0.792118010272337 Possible conserved exported protein VI - Unknowns Rv0310c - 19.1 21.1 6.8 7.1 4 9.69203745314845 -0.939366594722674 0.998363245566572 -0.940906627817195 0.346752710828931 0.547325357288803 hypothetical protein V - Conserved hypotheticals Rv0311 - 22.7 9.5 7.5 22.7 6.9 32.9265184250727 0.959126421399434 0.549952592095782 1.74401654830711 0.0811562043036389 0.200736924332046 hypothetical protein VI - Unknowns Rv0312 - 35.9 27 15.6 61.2 15.3 116.008826844593 1.27905945284735 0.354730657167183 3.60572007804935 0.000311288547703776 0.00233598312704825 Conserved hypothetical proline and threonine rich protein V - Conserved hypotheticals Rv0313 - 636 337.5 284.5 696.8 165.5 313.235664750722 0.746613399664318 0.281685484286418 2.65052138400274 0.00803676395695528 0.0339692338132883 hypothetical protein VI - Unknowns Rv0314c - 201.3 134.3 84.6 98.8 23.9 125.547304909649 -0.460203806759252 0.354590290315587 -1.29784661150667 0.194340048918016 0.370879554562291 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0315 - 70.9 50.8 27.4 44.4 21.8 74.5803172023953 0.266100556049928 0.420570491496289 0.632713329704151 0.526920863590106 0.707756427317465 Possible beta-1,3-glucanase precursor II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv0316 - 37.8 45.1 17.3 13.8 9.7 28.6826537779935 -0.68801012691409 0.657413456653542 -1.04654098566265 0.295311332326183 0.491085811251187 Possible muconolactone isomerase II.B.6 - Aromatic hydrocarbons Rv0317c glpQ2 144 122.5 57.1 77.3 10.2 105.990831937487 -0.669091001129875 0.434562799135732 -1.53968771017809 0.123636493958583 0.270822796290229 Possible glycerophosphoryl diester phosphodiesterase GlpQ2 (glycerophosphodiester phosphodiesterase) I.C.1 - General Rv0318c - 6 0 1.3 3.6 2.5 3.53187538826221 1.01138782152775 1.59890596156357 0.63254990965117 0.527027606279009 NA Probable conserved integral membrane protein ? Rv0319 pcp 39.7 27.7 18 14.4 5.8 24.4497321574179 -0.724341235351998 0.63356935607534 -1.14327062760571 0.252926246203896 0.444797915527221 Probable pyrrolidone-carboxylate peptidase Pcp (5-oxoprolyl-peptidase) (pyroglutamyl-peptidase I) (PGP-I) (pyrase) II.B.3 - Proteins, peptides and glycopeptides Rv0320 - 19.3 14.9 1.6 6.2 3 9.05376435607963 -0.678884318473094 1.101196217703 -0.616497139709749 0.537566459116993 0.717160225307868 Possible conserved exported protein V - Conserved hypotheticals Rv0321 dcd 36.8 24.1 25.2 27.4 24.1 35.4184264141958 0.707079378697314 0.581843490164026 1.21523982076002 0.224274636819641 0.408421986434534 Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0322 udgA 6.1 3.3 1.2 5.7 0 6.4479105673502 0.441370141553333 1.2054175619973 0.366155393341053 0.714249125255199 NA Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH) I.C.3 - Sugar nucleotides Rv0323c - 31.7 9.9 17.7 10.3 6.6 18.2596413811523 -0.5519405729012 0.748917907433729 -0.736984077190116 0.461132032471388 0.653430085400565 hypothetical protein V - Conserved hypotheticals Rv0324 - 31.4 35.1 14.5 12.7 6.6 24.3784075130893 -0.819749521786608 0.670775779018977 -1.22209171444071 0.221672946039751 0.405223171830146 Possible transcriptional regulatory protein (possibly ArsR-family) I.J.1 - Repressors/activators Rv0325 - 21.5 13.1 10.7 12.5 0.7 3.58784413329867 -0.392148176759527 1.53325560885223 -0.255761775463572 0.798134791142638 NA Hypothetical protein VI - Unknowns Rv0326 - 16.3 13.3 7.9 11.3 0 6.68287408921975 -0.32898226025261 1.16566406806207 -0.28222733227039 0.777769201703437 NA Hypothetical protein VI - Unknowns Rv0327c cyp135A1 4.7 2.5 1.6 0.3 0 3.42864243300131 -3.14390934723447 1.69627940887795 -1.85341479167875 0.063822928826622 NA Possible cytochrome P450 135A1 Cyp135A1 IV.F - Cytochrome P450 enzymes Rv0328 - 60.7 40.8 14.5 31.4 5.8 29.381592201815 -0.346553664505028 0.636415628508837 -0.544539839973802 0.586070040583612 0.754483040505571 Possible transcriptional regulatory protein (possibly TetR/AcrR-family) I.J.1 - Repressors/activators Rv0329c - 4.2 8.3 5 0.1 0 3.58914211373252 -4.13231104530459 1.87189590760315 -2.20755386478502 0.0272753882034156 NA hypothetical protein V - Conserved hypotheticals Rv0330c - 7.2 17.5 1.4 3.4 0 6.76648689675633 -1.53010447326834 1.38298804550335 -1.10637577688638 0.268563905518797 NA Hypothetical protein VI - Unknowns Rv0331 - 9.8 6.6 3.5 2.6 1.7 9.10637041998245 -1.06837650644623 1.00868910193087 -1.05917324218245 0.289520888737768 0.485550657153966 Possible dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0332 - 30.3 28.1 16.5 20.2 2.5 25.4798602341036 -0.529335023448181 0.666499452390736 -0.794201737975109 0.427077996904804 0.6222432483507 hypothetical protein VI - Unknowns Rv0333 - 75.3 46.8 46.8 77.5 37.5 44.4967359503126 0.782285261123027 0.487786625894831 1.60374479248574 0.108770318144532 0.247440248470091 hypothetical protein VI - Unknowns Rv0334 rmlA 23.9 23.1 14.4 27.6 11.9 35.6427738115937 0.706071914526216 0.536941942557508 1.31498744754996 0.188514121147691 0.363284557728575 Alpha-D-glucose-1-phosphate thymidylyltransferase RmlA (dTDP-glucose synthase) (dTDP-glucose pyrophosphorylase) I.C.3 - Sugar nucleotides Rv0335c PE6 7.5 3.3 5.4 2.9 0 2.8522177547701 -0.934147275593201 1.70768746852135 -0.547024729532074 0.584361742621991 NA PE family protein PE6 IV.C.1.a - PE subfamily Rv0336 - 108.1 70 60.4 30.4 23.4 167.620664013533 -0.665093266693031 0.382102396124909 -1.74061527338764 0.0817510386032063 0.201644542363387 Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0337c aspC 189.1 98.9 113.8 95.9 27.1 244.71569676827 -0.416652561882426 0.306519018762795 -1.35930410962479 0.174050242333311 0.343853296826176 Probable aspartate aminotransferase AspC (transaminase A) (ASPAT) I.D.2 - Aspartate family Rv0338c - 277.9 159 136.5 120.6 48.7 724.738927486105 -0.341778440987592 0.249352097078027 -1.37066599797091 0.170479098954005 0.339105116989886 Probable iron-sulfur-binding reductase V - Conserved hypotheticals Rv0339c - 32.3 20.9 12.5 13.4 1.6 65.4251767828136 -0.841753175674855 0.478673684757503 -1.75851149223148 0.0786605179052052 0.195932176104245 Possible transcriptional regulatory protein V - Conserved hypotheticals Rv0340 - 104.6 49.4 33.4 71.6 11.3 49.5127677733119 0.146677874910113 0.497360904317349 0.29491235365883 0.768060834585804 0.878421529255059 hypothetical protein VI - Unknowns Rv0341 iniB 45.3 20.6 10.4 138.3 23.5 136.857369648383 2.3553949602645 0.406902721443503 5.78859475775596 7.09777044260534e-09 1.81747364577054e-07 Isoniazid inductible gene protein IniB V - Conserved hypotheticals Rv0342 iniA 50.8 33.8 28.8 74.8 16 152.689964676696 0.930803944100511 0.33325196674091 2.79309362583349 0.00522065791048888 0.0238590772189859 Isoniazid inductible gene protein IniA V - Conserved hypotheticals Rv0343 iniC 48.8 18.3 20.8 27.6 13.2 73.7452934021775 0.322504766725776 0.424950801382395 0.758922599220065 0.447898859214587 0.642277823420826 Isoniazid inductible gene protein IniC V - Conserved hypotheticals Rv0344c lpqJ 12.4 11.5 6.2 3.6 0 5.84773526277364 -1.61717918689255 1.2951086904734 -1.24868221392401 0.211781328731438 NA Probable lipoprotein LpqJ II.C.1 - Lipoproteins(lppA-lpr0) Rv0345 - 24.9 0.1 17.4 11.9 5.8 9.65535605122271 0.0934695487392657 1.07669090522535 0.0868118679981814 0.930821053942454 0.968441588895881 hypothetical protein II.C.5 - Other membrane proteins Rv0346c ansP2 195.1 156.5 145.8 101.3 61.4 389.391156121341 -0.140270366995437 0.331707603790371 -0.422873534982586 0.672387532678334 0.817591999101511 Possible L-asparagine permease AnsP2 (L-asparagine transport protein) III.A.1 - Amino acids Rv0347 - 34.4 23.5 11.6 32.9 24.5 57.5511508452409 1.30088292898157 0.494116550137243 2.63274510562386 0.00846978850926354 0.0351699776082198 Probable conserved membrane protein V - Conserved hypotheticals Rv0348 - 20.2 14.1 18 29.1 23.3 33.071830581698 1.46228584220518 0.602555153146538 2.42680829226858 0.0152323024475509 0.0561423676058536 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0349 - 27.3 11.3 13.3 32 11.7 25.3352684030043 1.09605596973888 0.604908323355191 1.81193732574134 0.0699958811741038 0.178492016644115 Hypothetical protein VI - Unknowns Rv0350 dnaK 385.1 178.4 301.7 562.2 251 1412.7438636032 1.31677514547354 0.315812205412567 4.16948782506156 3.05284922920388e-05 0.0003337404928963 Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70) III.B - Chaperones/Heat shock Rv0351 grpE 414.8 196.9 622 390.5 357.2 681.933819926121 0.842601088743514 0.932871239495147 0.903234072474476 0.366401678034546 0.567350045263647 Probable GrpE protein (HSP-70 cofactor) III.B - Chaperones/Heat shock Rv0352 dnaJ1 395.1 133.8 203.4 281.5 90.2 499.235896367717 0.386990975508225 0.307777842305372 1.25737113695228 0.208619275683799 0.389320060311916 Probable chaperone protein DnaJ1 III.B - Chaperones/Heat shock Rv0353 hspR 329.3 170.1 292.7 236.7 113.1 177.938379750319 0.181528198918968 0.384643116696943 0.471939288756315 0.636970123557589 0.790521435753672 Probable heat shock protein transcriptional repressor HspR (MerR family) III.B - Chaperones/Heat shock Rv0354c PPE7 20 2.4 14.2 10.9 8.7 10.2905897549204 0.491443114233292 0.987449132312927 0.497689549923623 0.618702874781456 0.776623700814895 PPE family protein PPE7 IV.C.2 - PPE family Rv0355c PPE8 33.9 27 27.1 25.7 17 560.998723130922 0.471075033381885 0.337436544962487 1.3960403531107 0.162702343791221 0.328933619696634 PPE family protein PPE8 IV.C.2 - PPE family Rv0356c - 38.1 17.1 13.9 23 10.4 24.3513560795101 0.33678281343405 0.625021336654012 0.538834106427442 0.590001327590895 0.757409331039006 hypothetical protein VI - Unknowns Rv0357c purA 44.3 17.5 21.3 42.5 11.1 67.0366208682049 0.704888458281659 0.4272106858702 1.64997852721275 0.0989473279710356 0.231640076453013 Probable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase) I.F.1 - Purine ribonucleotide biosynthesis Rv0358 - 12.4 2.6 5.1 2.4 2.6 5.32103006577464 -0.832983333627471 1.3429974521949 -0.620241931409552 0.53509851900545 NA hypothetical protein VI - Unknowns Rv0359 - 5.9 0.7 5.2 1.9 2.5 4.43335231290467 -0.515813444738797 1.51912977411345 -0.339545345979293 0.734198942650251 NA Probable conserved integral membrane protein V - Conserved hypotheticals Rv0360c - 28.1 16.7 19.3 7.3 11.3 15.2805053025801 -0.420791388123101 0.864578247207639 -0.486701336151062 0.626469998214649 0.782596643106496 hypothetical protein VI - Unknowns Rv0361 - 158.1 139 125.1 48.8 31.3 156.9622350744 -1.03612655185888 0.391212429515482 -2.64850110499332 0.00808495849317008 0.0340941498092227 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0362 mgtE 36.4 30.2 18.8 6.6 4.3 46.9078019937524 -1.65001135954616 0.543554922853563 -3.03559270677543 0.00240063409399142 0.0129422312951562 Possible Mg2+ transport transmembrane protein MgtE III.A.2 - Cations Rv0363c fba 298.7 211.7 147.4 175 45.4 327.268482149529 -0.288714611213599 0.281362572601022 -1.02613012293928 0.304830253178607 0.500792558793425 Probable fructose-bisphosphate aldolase Fba I.B.1 - Glycolysis Rv0364 - 152.8 87.7 85.3 95.2 30.1 114.774541971165 -0.054576304231813 0.34975800019745 -0.156040188361675 0.876001343458179 0.93588751858224 Possible conserved transmembrane protein V - Conserved hypotheticals Rv0365c - 45.6 24.5 19.1 26.9 4 44.7996798444512 -0.268344514030272 0.520197989677919 -0.515850732519011 0.605958666221156 0.76692285009813 hypothetical protein V - Conserved hypotheticals Rv0366c - 35.4 8.5 33 12.2 3.3 18.4156795132571 -1.18384634161222 0.838831755688702 -1.41130367750593 0.158155090606511 0.323619486382589 hypothetical protein V - Conserved hypotheticals Rv0367c - 86.1 86 46.7 43.2 24.8 43.3831535076375 -0.307571954357702 0.530211759786129 -0.580092668034686 0.561852127871111 0.73610156192777 Hypothetical protein VI - Unknowns Rv0368c - 1 2.1 0 0.7 0 1.27597512476978 -0.384045415358532 2.46716141111343 -0.155662865683851 0.876298769181125 NA hypothetical protein V - Conserved hypotheticals Rv0369c - 15 10 4.2 5.4 3.8 6.6196022075268 -0.521612731441339 1.15154510427418 -0.452967694886873 0.650572003888712 NA Possible membrane oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0370c - 7.5 7.7 1.2 4.7 2.2 6.70855037570106 0.100318728378816 1.17339074760754 0.0854947327506706 0.93186808279739 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0371c - 2.2 0 0 1.2 0 0.442395837673083 0.688228224721522 4.03739730173258 0.170463338950115 0.864645763642738 NA hypothetical protein II.C.5 - Other membrane proteins Rv0372c - 1 0 0.7 0.9 0 0.318962141281706 1.17223380750856 4.41539034622166 0.265488148406101 0.790633438594006 NA hypothetical protein V - Conserved hypotheticals Rv0373c - 6.7 5 4.5 7.1 1.6 21.9459136521009 0.40204556431402 0.648051397121194 0.62039147836114 0.535000081425563 0.71481338680096 Probable carbon monoxyde dehydrogenase (large chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0374c - 3.6 0 0.8 2.3 0 0.711984500398238 0.914730331683237 3.33218727834453 0.274513481768553 0.783690044469548 NA Probable carbon monoxyde dehydrogenase (small chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0375c - 2.9 0 1.9 1 0 1.35015959556462 -0.62850735437351 2.38713793348693 -0.263289081689318 0.792327774453555 NA Probable carbon monoxyde dehydrogenase (medium chain) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0376c - 6.7 1.5 0.9 7.1 1.7 6.40238184909702 1.3518427923597 1.21552447643597 1.11214773422205 0.266074635766281 NA hypothetical protein V - Conserved hypotheticals Rv0377 - 31.2 21.7 17.2 13.9 1 25.8657875812091 -1.05297614651488 0.708779713226127 -1.48561834779679 0.137380099126109 0.29225243910191 Probable transcriptional regulatory protein (probably LysR-family) I.J.1 - Repressors/activators Rv0378 - 2.2 3.5 0 1.5 0 0.184167809919128 1.00293571130176 4.4274868195387 0.22652483275066 0.820793247395944 NA Conserved hypothetical glycine rich protein V - Conserved hypotheticals Rv0379 secE2 131.8 34.7 39 256.7 54.3 43.4177368926769 1.86964376777633 0.53741854518145 3.47893422089681 0.000503412138575308 0.00350311551047886 Possible protein transport protein SecE2 III.D - Protein and peptide secretion Rv0380c - 59.5 20.4 21.1 5.6 0 17.0055294494372 -2.67415849848466 0.900477332601648 -2.96971217560637 0.00298078887197071 0.0152351431234058 Possible RNA methyltransferase (RNA methylase) IV.H - Miscellaneous transferases Rv0381c - 58.4 24.8 26.8 28.9 8.3 46.8013769794726 -0.216067575065746 0.485557068259419 -0.444989042874581 0.656327672520323 0.805868918214254 Hypothetical protein VI - Unknowns Rv0382c pyrE 273.4 154.7 119.8 160.6 27.3 136.219151621262 -0.280206566118875 0.363188707250131 -0.77151783776662 0.440400053529113 0.634104467317121 Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv0383c - 608.1 335.5 267.3 344.4 90.4 504.435997811361 -0.161291107186317 0.258380091913417 -0.624239685000054 0.532470188045992 0.712472486026145 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0384c clpB 39.2 21.6 18.3 51.8 13.8 145.540826070372 1.04064410915887 0.323944416797743 3.21241563428027 0.00131623800448708 0.00783548741494664 Probable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1) III.B - Chaperones/Heat shock Rv0385 - 15.4 7.4 5.9 11.2 5 20.7595810075396 0.616864465181877 0.666532896364242 0.925482400863794 0.354715034043183 0.554445977368376 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0386 - 14.3 6.9 6 18.1 6.1 67.7499822319114 1.19766642825571 0.411087804943954 2.91340782638638 0.00357507361868461 0.0175386575586993 Probable transcriptional regulatory protein (probably LuxR/UhpA-family) I.J.1 - Repressors/activators Rv0387c - 5.6 0 2.9 3.4 0 2.58145767125404 -0.03516637230026 1.87063985882676 -0.0187991141824145 0.985001360478886 NA hypothetical protein V - Conserved hypotheticals Rv0388c PPE9 9.8 3.6 7.6 6 2.8 5.63891878816787 0.0738933512749958 1.23509662157445 0.0598279923888057 0.952292630801561 NA PPE family protein PPE9 IV.C.2 - PPE family Rv0389 purT 34.6 6.6 17.5 28.1 15.8 55.1349122294861 1.02328016718888 0.522961554290568 1.95670247419436 0.0503824588434328 0.140892068046728 Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase) I.F.1 - Purine ribonucleotide biosynthesis Rv0390 - 78 29.6 27.4 58 25.3 36.9265771374538 0.728675388659521 0.533290370864565 1.36637642168224 0.171820845458027 0.341137575455343 hypothetical protein VI - Unknowns Rv0391 metZ 42.8 25.2 16.5 22.2 7.3 49.4680782433107 -0.164077210556156 0.46782055759069 -0.350726807306558 0.725793312216284 0.852373976084243 Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase) I.D.2 - Aspartate family Rv0392c ndhA 44.3 33 26.8 34.5 14 84.6530082967435 0.239201003454013 0.388868044522864 0.615121264971796 0.53847463956708 0.717561013298193 Probable membrane NADH dehydrogenase NdhA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0393 - 1.1 0 0 1.4 0 0.918873580259768 1.55638773391947 3.02244425280829 0.514943404654481 0.606592568887922 NA Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0394c - 44.1 31.2 23.4 19.9 8.2 33.5665544277177 -0.448826079205465 0.551157597101021 -0.814333471163604 0.415453939910033 0.611611743624828 Possible secreted protein VI - Unknowns Rv0395 - 2.2 0 1.5 1 0 0.258228027753954 0.616797980480997 4.42497613393415 0.139390125915236 0.889141874567981 NA Hypothetical protein VI - Unknowns Rv0396 - 1.8 0 0 1.2 0 0.318962141281706 1.17223380750856 4.41539034622166 0.265488148406101 0.790633438594006 NA Hypothetical protein VI - Unknowns Rv0397 - 2.5 0 0 0.1 0 0.172807174947927 -0.25937561286276 4.45633197988856 -0.0582038353590628 0.953586265728918 NA Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0397A - 111.7 34.9 25.1 270.7 78 55.7248300228891 2.4088087982641 0.500464205929371 4.81314901190766 1.48570423841575e-06 2.34926982699491e-05 hypothetical protein ? Rv0398c - 37.7 22.1 16.7 14.3 1 17.8116207235722 -1.07482050984021 0.804604448294731 -1.3358371459643 0.1816025087128 0.354204893095119 Possible secreted protein VI - Unknowns Rv0399c lpqK 54.7 34.1 40.4 28.2 9.8 76.5532647805412 -0.469456765227243 0.421503928815822 -1.11376604850669 0.265379565826132 0.459196102665442 Possible conserved lipoprotein LpqK II.C.1 - Lipoproteins(lppA-lpr0) Rv0400c fadE7 90.8 55.6 48.3 43.3 9.7 101.950732455991 -0.596431352322845 0.378216438792885 -1.57695777112813 0.114805242122195 0.257856796193288 Acyl-CoA dehydrogenase FadE7 I.A.3 - Fatty acids Rv0401 - 13 4.4 4.1 2.7 0 2.32808119035976 -1.19882313289381 1.85425307961522 -0.646526165210727 0.517938657597572 NA Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0402c mmpL1 20 17.3 11.9 5.2 2.7 58.4286359515099 -1.37253868408147 0.482273675785809 -2.84597470895561 0.00442757112244519 0.0207714661135111 Probable conserved transmembrane transport protein MmpL1 II.C.4 - Conserved membrane proteins Rv0403c mmpS1 12.7 9.3 8.6 4.8 0 4.40457000072005 -1.19763901569291 1.42738474164173 -0.839044289008875 0.401444456911058 NA Probable conserved membrane protein MmpS1 II.C.4 - Conserved membrane proteins Rv0404 fadD30 52.9 34.5 22.5 36 15.3 109.715179257397 0.300856488584874 0.358318526215339 0.83963419855123 0.401113518374791 0.599976386014995 Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv0405 pks6 61.7 53.3 39.6 23.4 9.9 290.609838065804 -0.859431257382565 0.310402619008556 -2.7687629058274 0.00562695666819801 0.0253335582232402 Probable membrane bound polyketide synthase Pks6 I.I - Polyketide and non-ribosomal peptide synthesis Rv0406c - 21.5 12.5 9.8 11.6 2.4 15.134981485165 -0.392957938407066 0.784093428544 -0.501162137191684 0.616257018912951 0.774585649747932 Beta lactamase like protein V - Conserved hypotheticals Rv0407 fgd1 56.7 37.8 32.1 26.6 7.1 57.6361730819524 -0.59878161399094 0.448008248006026 -1.33654149595676 0.181372346785289 0.354204893095119 F420-dependent glucose-6-phosphate dehydrogenase Fgd1 IV.G - Coenzyme F420-dependent enzymes Rv0408 pta 67.3 42.1 43.1 27.1 5.1 132.366769050857 -0.982927871570504 0.370662577448378 -2.65181308115033 0.00800608498492057 0.0339108395383134 Probable phosphate acetyltransferase Pta (phosphotransacetylase) I.A.1 - Carbon compounds Rv0409 ackA 85.2 57.4 42.6 22.8 10.1 87.8109338618851 -1.18190406467094 0.398958866410614 -2.96247098179416 0.00305180573951831 0.0154863838529711 Probable acetate kinase AckA (acetokinase) I.B.6.c - Electron transport Rv0410c pknG 165.9 81.3 75.3 288.7 97.4 688.186212059038 1.64682662124215 0.24639377657161 6.68371841268291 2.32954232385589e-11 9.70733989540891e-10 Serine/threonine-protein kinase PknG (protein kinase G) (STPK G) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0411c glnH 163.4 98.4 74.2 265.4 94.7 295.509404893311 1.49568335065395 0.273451420626107 5.46964922409021 4.50927128847925e-08 9.62158970108042e-07 Probable glutamine-binding lipoprotein GlnH (GLNBP) III.A.1 - Amino acids Rv0412c - 239.7 189.1 90.5 274.3 87.5 463.276290302732 0.841737034333844 0.289055938102098 2.91202125049074 0.00359098204392524 0.0175856761723431 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0413 mutT3 70.8 37.6 34.6 37.2 12.4 44.8341754615941 -0.21815740980991 0.483862254081234 -0.450866766253861 0.652085577315011 0.802810954066656 Possible mutator protein MutT3 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0414c thiE 15.3 5.2 4.8 11.1 1.5 7.32067181214021 0.0908670172094505 1.13102699134171 0.0803402729599379 0.9359666285263 0.972161509425038 Thiamine-phosphate pyrophosphorylase ThiE (TMP pyrophosphorylase) (TMP-PPASE) (thiamine-phosphate synthase) I.G.8 - Thiamine Rv0415 thiO 36 13.3 12.6 22.4 8.7 35.5328311510506 0.37763156338312 0.540182893945442 0.699080936504555 0.484501451415593 0.672454600671642 Possible thiamine biosynthesis oxidoreductase ThiO V - Conserved hypotheticals Rv0416 thiS 14.9 12.5 7.6 15.5 2.2 3.07596025430694 0.258016269417509 1.61628932586184 0.159634952287969 0.873168644097268 NA Possible protein ThiS V - Conserved hypotheticals Rv0417 thiG 15.4 1.3 5.6 16.2 8.6 15.326668765637 1.5638009225537 0.824022370596266 1.89776513157297 0.0577270283765005 0.156321968279484 Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein) I.G.8 - Thiamine Rv0418 lpqL 67.4 40.4 39.5 35 22.6 124.518196639756 0.104951034078345 0.382468178247837 0.274404617291683 0.783773695064445 0.885336132396263 Probable lipoprotein aminopeptidase LpqL II.C.1 - Lipoproteins(lppA-lpr0) Rv0419 lpqM 133.8 72 72 110.3 49.1 267.758965763311 0.625441158490606 0.295743668714443 2.11480827707762 0.0344462911392664 0.105089374001104 Possible lipoprotein peptidase LpqM II.C.1 - Lipoproteins(lppA-lpr0) Rv0420c - 49.8 31.1 19.3 21.1 4.8 16.6181250601398 -0.695314720174917 0.762245239357868 -0.912192932501179 0.361667163724166 0.563013783263851 Possible transmembrane protein VI - Unknowns Rv0421c - 80.4 38.2 29.6 14.1 18 42.5413871129863 -0.724697998485526 0.59926029109233 -1.20932090655389 0.226539581905007 0.409807558277597 hypothetical protein VI - Unknowns Rv0422c thiD 115 49.7 41.8 43.3 11.8 69.7298310693598 -0.56600938235307 0.43243118164452 -1.30890048261681 0.190568063131271 0.365849365642798 Probable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase) I.G.8 - Thiamine Rv0423c thiC 240.2 176.1 116.3 92.9 25.3 373.357588575804 -0.863375957966451 0.279972215790196 -3.08379156670833 0.0020438073091052 0.0112061385276325 Probable thiamine biosynthesis protein ThiC I.G.7 - Pyridine nucleotide Rv0424c - 245.3 132.6 117 59.7 60.5 65.8609608915354 -0.518084585965718 0.505536097457313 -1.02482214142871 0.305447117067721 0.501573337345326 Hypothetical protein VI - Unknowns Rv0425c ctpH 109.2 60.7 55.6 39.5 8.8 432.069641600468 -0.951753642849074 0.280280479517162 -3.39571861903711 0.000684486867431265 0.00453168688680662 Possible metal cation transporting P-type ATPase CtpH III.A.2 - Cations Rv0426c - 156.7 122.7 125 178.5 76.9 123.019940975751 0.673955681625784 0.369520514623322 1.82386540112068 0.0681724234922311 0.174722665708743 Possible transmembrane protein VI - Unknowns Rv0427c xthA 40.6 29 19.3 13.3 13.5 41.050271537925 -0.224092652760922 0.577823396708151 -0.387822047424133 0.698147728551676 0.832886242684418 Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0428c - 19.6 21.3 5 2.2 0 13.2574016122566 -2.83570958682572 1.04171842956161 -2.72214593344487 0.00648594938874534 0.0285736725558905 GCN5-related N-acetyltransferase VI - Unknowns Rv0429c def 43.7 35.6 21.2 6.2 3.3 21.1014695195988 -2.25050462602404 0.749283861275108 -3.00354077050879 0.00266857791036092 0.0140249837203443 Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) II.A.6 - Protein translation and modification Rv0430 - 68.5 27.7 19.2 77 2.7 18.4104562919124 0.596395194041279 0.81509580916662 0.731687229076853 0.464359493055144 0.656853564058035 hypothetical protein VI - Unknowns Rv0431 - 97.1 68 59.4 40.4 23.6 53.8127342778656 -0.489254067989532 0.476081816270736 -1.02766804206465 0.304106005555838 0.500298872122052 Putative tuberculin related peptide II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0432 sodC 214.2 141.6 97.4 85.4 29.8 146.138666568568 -0.609937739631661 0.331699528135654 -1.83882606966573 0.0659407725204632 0.170732614230615 Periplasmic superoxide dismutase [Cu-Zn] SodC III.F - Detoxification Rv0433 - 199.6 140.2 85.7 87.6 24 211.920053777599 -0.615762946937265 0.312627408543592 -1.9696383941698 0.0488798280925364 0.137625080368652 hypothetical protein V - Conserved hypotheticals Rv0434 - 94.5 42.3 49.6 15.9 9.1 47.4685354463674 -1.56112745659577 0.53169069752976 -2.93615717530659 0.00332305902303438 0.0164667078960714 hypothetical protein V - Conserved hypotheticals Rv0435c - 51.8 33.5 27.9 17.1 4.4 101.006911952065 -1.06862755667489 0.378422924986378 -2.82389751285116 0.00474435528764571 0.0218524140817179 Putative conserved ATPase III.C - Cell division Rv0436c pssA 84.5 56.3 29.1 61.3 17.1 77.9545158243345 0.239810649336046 0.406229703546252 0.590332630141464 0.554967667364147 0.730198914488785 Probable CDP-diacylglycerol--serine O-phosphatidyltransferase PssA (PS synthase) (phosphatidylserine synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0437c psd 43.3 10.4 23.6 24.7 10.1 28.7211435153081 0.136360748533004 0.616965481315918 0.221018440516577 0.825078074560933 0.906459844942564 Possible phosphatidylserine decarboxylase Psd (PS decarboxylase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0438c moeA2 21.8 13.9 19.7 11.5 0 27.2031898351515 -1.09181964823689 0.724042867581931 -1.507948903472 0.131567605020327 0.283635092502737 Probable molybdopterin biosynthesis protein MoeA2 I.G.4 - Molybdopterin Rv0439c - 30.7 29.7 12.7 7.2 8.4 31.1374987468466 -0.85661523679309 0.664115970200274 -1.28985790920638 0.197099997183153 0.374130862820326 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0440 groEL2 326.8 163.1 173 650.7 243.8 1135.4027142794 1.83440477598937 0.245749760584558 7.46452314592667 8.36018182939994e-14 5.69457000764127e-12 60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) (heat shock protein 65) (cell wall protein A) (antigen A) III.B - Chaperones/Heat shock Rv0441c - 55.4 32 20 27.4 0 17.8139766181496 -0.665414919351258 0.803500666125272 -0.828144826015009 0.40758848590729 0.604865709307802 Hypothetical protein II.C.5 - Other membrane proteins Rv0442c PPE10 33 20.7 21.7 33.8 3.4 57.7649846149446 0.143068501363685 0.496931322583951 0.287903971558394 0.773420246714486 0.881423631580758 PPE family protein PPE10 IV.C.2 - PPE family Rv0443 - 169.7 97.2 85.4 58.9 14.6 74.7042493035527 -0.940301151591928 0.416223150551863 -2.25912746646888 0.0238754570607653 0.0794801399522844 hypothetical protein VI - Unknowns Rv0444c rskA 144.9 114.4 67 56.8 11.4 92.911898745395 -0.978129935721979 0.411871350552823 -2.37484334467331 0.0175563995669353 0.0630038168855976 Anti-sigma factor RskA (regulator of sigma K) V - Conserved hypotheticals Rv0445c sigK 73.5 53.6 43.9 75.2 16.7 55.8108679725492 0.396390931588792 0.448858194026474 0.883109491737188 0.377177116288399 0.577837952376086 Alternative RNA polymerase sigma factor SigK II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0446c - 54.7 32.4 21.9 20.9 7.1 36.2408793822837 -0.648510302503344 0.535696837994611 -1.2105919925364 0.226051814680991 0.409681298300799 Possible conserved transmembrane protein V - Conserved hypotheticals Rv0447c ufaA1 27.5 15.6 11 8.8 1.2 26.2382758894347 -1.10871749458478 0.650391201630537 -1.70469325508281 0.0882516484656812 0.212588411831909 Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) I.H.2 - Modification of fatty and mycolic acids Rv0448c - 5.3 2.6 5.4 2 5.9 6.88221700206465 0.817026002253969 1.24935137514482 0.653960141644909 0.513137485184231 NA hypothetical protein V - Conserved hypotheticals Rv0449c - 17.5 16.7 8.8 7.8 1.5 22.8770055243986 -0.97266541722124 0.692279444020274 -1.40501848729276 0.160015780918656 0.325799260451735 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0450c mmpL4 83 68.4 51.1 46.8 17.7 292.475360376493 -0.309362531752758 0.295814758713124 -1.04579816469797 0.295654228709631 0.491239576406811 Probable conserved transmembrane transport protein MmpL4 II.C.4 - Conserved membrane proteins Rv0451c mmpS4 120.5 114.8 77.8 67.6 36.8 69.5525759483173 -0.204247502613236 0.44830057147053 -0.455603930959214 0.648674815893634 0.800280807347701 Probable conserved membrane protein MmpS4 II.C.4 - Conserved membrane proteins Rv0452 - 4.6 4.9 4.5 3.6 0 4.10636366004488 -0.707879964915052 1.47347685268123 -0.480414716815502 0.630932531753956 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0453 PPE11 2.8 1.1 0.7 2.1 0 2.71038415234953 0.387885435081834 1.7487976609606 0.221801208762352 0.824468638440071 NA PPE family protein PPE11 IV.C.2 - PPE family Rv0454 - 3.7 0 0.3 4.7 0 0.78407924889719 1.56480628845475 3.21081116234534 0.487355440521059 0.626006465374926 NA hypothetical protein V - Conserved hypotheticals Rv0455c - 825.8 891.6 625 561.3 256.4 559.962772214504 -0.15070909039445 0.313305471852475 -0.481029231642063 0.630495723254124 0.784685822827163 hypothetical protein VI - Unknowns Rv0456c echA2 9.6 9.2 4.8 4.9 0 8.13282780972836 -0.906270682445725 1.10114940721395 -0.823022449549969 0.410495227169269 0.606833929312834 enoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0456A mazF1 32 12.2 1.6 26 1.5 5.52500804651626 0.549566743510947 1.41625954378129 0.388040981558827 0.697985706224882 NA Possible toxin MazF1 ? Rv0456B mazE1 34.1 1 4.3 53.7 10.8 6.08510580680769 1.95371436093805 1.29947736759465 1.50346162977382 0.13272004435753 NA Possible antitoxin MazE1 ? Rv0457c - 17 6.8 9.8 11.2 4.3 37.7816795956363 0.224511574476064 0.527973233807412 0.425232871857968 0.670666923344395 0.816743718855789 Probable peptidase II.B.3 - Proteins, peptides and glycopeptides Rv0458 - 79.5 53.5 41.1 64.7 23.3 156.353099867765 0.385514334701627 0.317531580108785 1.21409761690333 0.224710449930968 0.408585427954563 Probable aldehyde dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0459 - 55.3 23.9 25.3 45.1 10 28.2899304803096 0.393380064731324 0.584888224438137 0.672573063185224 0.501218943458937 0.686511020004468 hypothetical protein V - Conserved hypotheticals Rv0460 - 67.9 41.3 16.5 72.7 19.6 19.8329447813003 0.973378845693667 0.686068646477639 1.41877762624938 0.155963857538543 0.320060245307949 Conserved hydrophobic protein V - Conserved hypotheticals Rv0461 - 38.8 20 11.1 48.2 4.6 22.0830365497618 0.859107898561391 0.685663097490793 1.2529592181719 0.210220548775225 0.390866763129579 Probable transmembrane protein II.C.5 - Other membrane proteins Rv0462 lpdC 179.3 113.6 74.6 188 53.8 330.391003810208 0.733997199555748 0.273804429071392 2.68073530455698 0.00734605974870556 0.031654189330797 Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) I.B.2 - Pyruvate dehydrogenase Rv0463 - 56 31.7 35.4 68.6 8.7 21.0899345812882 0.542744316267507 0.678784013681465 0.799583233146387 0.42395230509249 0.618722317526823 Probable conserved membrane protein V - Conserved hypotheticals Rv0464c - 158.8 119.9 63.1 86.8 41.1 102.274246919235 -0.0118523149841392 0.384215869310499 -0.0308480620683601 0.975390710652176 0.990491369590025 hypothetical protein V - Conserved hypotheticals Rv0465c - 59.8 32 31.4 23.6 16.4 90.8882949836156 -0.177050762700779 0.419173121513228 -0.422381001104318 0.672746943103768 0.817591999101511 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0466 - 97 56.2 45.4 58.5 13.9 76.64933897739 -0.143562034816737 0.401786036588617 -0.357309666696376 0.720859994035344 0.849224787904526 hypothetical protein V - Conserved hypotheticals Rv0467 icl1 74.5 96.1 42.2 25.9 12.3 117.716636866848 -1.13532560746477 0.432679300861017 -2.62394250246202 0.00869184568935539 0.0355502510758623 Isocitrate lyase Icl (isocitrase) (isocitratase) I.B.4 - Glyoxylate bypass Rv0468 fadB2 33.3 37.2 8.6 23.5 11.1 37.877815369092 0.281552877758781 0.590668372629288 0.476668280892514 0.633598353029035 0.787993457313498 3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) I.A.3 - Fatty acids Rv0469 umaA 276.1 261.4 204.4 280.8 88.4 378.009534859539 0.263414945517467 0.298583448139961 0.882215498408977 0.377660282352314 0.578328024250712 Possible mycolic acid synthase UmaA I.H.2 - Modification of fatty and mycolic acids Rv0470c pcaA 401.6 290.8 217.5 303.4 148.6 480.283724627618 0.446103874716512 0.281384215130746 1.5853905469048 0.112877627631928 0.254495580567975 Mycolic acid synthase PcaA (cyclopropane synthase) I.H.2 - Modification of fatty and mycolic acids Rv0470A - 48.9 27.7 22.9 16.2 7 18.1339533282304 -0.810279698536249 0.721607955834384 -1.12288077201052 0.261488134798167 0.455345779254933 Hypothetical protein ? Rv0471c - 105 48.7 55 48.5 10.1 44.8058520866579 -0.527724060738191 0.502654635221173 -1.04987405618171 0.293776021049589 0.489442458399644 Hypothetical protein VI - Unknowns Rv0472c - 336.2 211.9 141.6 235.5 75.9 265.540738361381 0.219437757849124 0.283391415201523 0.774327471045936 0.438737162337097 0.633254698043194 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0473 - 87.3 56.9 53.1 76.9 38.6 179.91302890159 0.646337239074659 0.329995693646735 1.95862325332818 0.0501569243029082 0.140439388048143 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0474 - 172.8 84.8 111.3 294.6 142.5 157.545813622284 1.66631579970222 0.350421241479506 4.75517920279863 1.98270464744128e-06 3.04014712607663e-05 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0475 hbhA 465.9 252.9 226.4 483.5 268.1 452.558811253859 1.20735194918116 0.295269139165396 4.08898794026984 4.3325937499146e-05 0.000448714826380045 Iron-regulated heparin binding hemagglutinin HbhA (adhesin) II.C.5 - Other membrane proteins Rv0476 - 629.4 346.1 203.7 536.4 175 192.322581958755 0.679537810941895 0.318688170134477 2.13229694298081 0.0329824432121741 0.101834257129666 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0477 - 255.3 186.8 109.7 234.7 64.2 143.934284002041 0.444741809344556 0.33396443184179 1.33170411858484 0.182957435352077 0.355926293098279 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0478 deoC 124 51.6 60.6 67 31 86.2662532397881 0.132294094753352 0.400771650761435 0.330098435111374 0.741325585623484 0.862606841090138 Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase) I.F.4 - Salvage of nucleosides and nucleotides Rv0479c - 91 59.5 62.1 90.8 69.7 183.997706019945 1.15156219189209 0.383843202016967 3.00008489362588 0.00269904368771089 0.0141629818398103 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv0480c - 44.4 24.8 11.5 20.6 7.1 32.2867470904933 -0.134762423021719 0.573951103148591 -0.23479774197216 0.814365720401958 0.90224691325109 Possible amidohydrolase V - Conserved hypotheticals Rv0481c - 56.6 42.4 35.6 41.6 3.8 31.488731802087 -0.40436942401926 0.624317921335128 -0.647697927931494 0.517180344690481 0.701544784749428 Hypothetical protein VI - Unknowns Rv0482 murB 17.1 9.4 7.4 4.8 0 13.0607951351119 -1.44881266783532 0.916248310327317 -1.58124457257416 0.113822127531622 0.256135943911693 Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase) II.C.3 - Murein sacculus and peptidoglycan Rv0483 lprQ 619.6 286 249.7 222.5 43.5 640.735208772106 -0.855576261361958 0.288466168155487 -2.96595010372513 0.00301749440589949 0.0153562718185288 Probable conserved lipoprotein LprQ V - Conserved hypotheticals Rv0484c - 42.3 21.2 21.4 24.8 11 35.2059940794298 0.136755809768377 0.536140831035471 0.255074416742807 0.798665623223004 0.895213176410089 Probable short-chain type oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0485 - 320.4 154.4 142.4 108.5 26.4 335.237711728254 -0.875782148103302 0.289519236109113 -3.02495322892204 0.00248671578997377 0.0132762446009738 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0486 mshA 275.5 159.4 139.2 142.2 41.6 394.669697010016 -0.323331219436732 0.263712791600719 -1.22607332573492 0.22017108271496 0.403229563069487 Glycosyltransferase MshA V - Conserved hypotheticals Rv0487 - 185.2 96.2 85.1 207.9 39.3 125.403495871467 0.688692631125734 0.358798225141056 1.91944269193356 0.0549283324023419 0.150468796109122 hypothetical protein V - Conserved hypotheticals Rv0488 - 13.9 3.6 4.5 16.5 11 13.5798352426276 1.72432274758415 0.840217690537965 2.05223332834151 0.0401469919290471 0.119295843467017 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0489 gpm1 151.9 94.2 60.3 60.9 7.9 92.4430001259039 -0.863045056613864 0.423656896745771 -2.03713208316248 0.041636807581327 0.122084083156507 Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) I.B.1 - Glycolysis Rv0490 senX3 350.2 229.3 234.5 294.8 149.5 651.427969421766 0.575893482706229 0.287961717885074 1.99989598247941 0.0455114970776872 0.130633486749731 Putative two component sensor histidine kinase SenX3 I.J.2 - Two component systems Rv0491 regX3 150.2 93 102.6 207.6 45.1 159.422124409634 0.770755928113569 0.342307808185187 2.25164576934393 0.0243446662560871 0.080754608268565 Two component sensory transduction protein RegX3 (transcriptional regulatory protein) (probably LuxR-family) I.J.2 - Two component systems Rv0492c - 14.5 10.9 1.9 5.8 1 19.9320073889996 -0.686689686214156 0.806777645377991 -0.85115110730718 0.394685418508932 0.594614104267602 Probable oxidoreductase GMC-type I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0492A - 4.2 4.8 6.9 3.4 0 1.85053002888461 -0.673865006959259 2.01948840311901 -0.33368104809045 0.738620252142756 NA Hypothetical protein ? Rv0493c - 7.9 8.9 6.4 3.7 2 9.74921569356744 -0.938701309510485 0.980174349303887 -0.957688099241879 0.33822005954683 0.53947231466201 hypothetical protein V - Conserved hypotheticals Rv0494 - 0.5 0 0 0.6 0 0.159481070640853 1.1765567663428 4.42884339089194 0.265657794258978 0.79050277092913 NA Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0495c - 204.5 133 145.4 126.2 74.7 251.262741839637 0.197357330119725 0.341709944445462 0.577558052751444 0.563562534152815 0.73658247083737 hypothetical protein V - Conserved hypotheticals Rv0496 - 108.6 51.3 46.6 74.3 24 113.229237357764 0.300286652632475 0.351095725003287 0.855284275049672 0.39239379078785 0.593196247106515 hypothetical protein V - Conserved hypotheticals Rv0497 - 98.5 73.3 44.1 46.7 25.4 103.557314894399 -0.138722102187054 0.390983309668869 -0.354803130354951 0.722737083078925 0.849911935015123 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0498 - 47.4 29.1 31.8 16.3 5.7 38.9450307858676 -0.976053216172729 0.53577763170376 -1.82175058908096 0.0684928380992486 0.175163633608331 hypothetical protein V - Conserved hypotheticals Rv0499 - 35.5 33.9 21.1 7.6 0.9 27.5273446224833 -2.17742649644715 0.726253643613418 -2.99816257804028 0.00271612737518637 0.014210521658656 hypothetical protein VI - Unknowns Rv0500 proC 89 67.2 47.3 33 6.9 73.6614740779489 -1.04632937581812 0.429913303349713 -2.4338148358414 0.0149406358614038 0.055239803988614 Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase) I.D.1 - Glutamate family Rv0500A - 252 159.8 106.1 485.9 46.7 89.3046970181889 1.18024334962516 0.451899498067313 2.61173857167983 0.00900831105438899 0.0365270761792879 hypothetical protein ? Rv0500B - 496.5 313.1 176.7 1017.8 74.2 74.138438943085 1.26992673392659 0.501545477757595 2.53202708477089 0.0113405231048958 0.0441408053159791 hypothetical protein ? Rv0501 galE2 228.4 115.5 134.7 399 175.4 543.973455360514 1.6966663758265 0.278844659920397 6.08462925670105 1.16761173620171e-09 3.53476988856963e-08 Possible UDP-glucose 4-epimerase GalE2 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.A.1 - Carbon compounds Rv0502 - 317.9 161.6 163.2 509.4 181.9 619.839254884323 1.48753462867554 0.251516320266835 5.91426682410669 3.33357114325779e-09 9.08269922263006e-08 hypothetical protein V - Conserved hypotheticals Rv0503c cmaA2 191.1 186.8 114.6 144.4 71.6 261.915427469485 0.236972953146302 0.33114714702936 0.715612244502567 0.474230810837834 0.6633987093158 Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 2) (mycolic acid trans-cyclopropane synthetase) I.H.2 - Modification of fatty and mycolic acids Rv0504c - 63.9 52.6 43 65.1 25.2 50.0194194718218 0.501714253637465 0.46763336908014 1.07287949665432 0.283325186499037 0.479805307564333 hypothetical protein V - Conserved hypotheticals Rv0505c serB1 108.1 62.6 48.1 78.9 29.1 140.769854991966 0.365592814220877 0.326159150264464 1.12090313555342 0.262329096074092 0.455698704411199 Possible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase) I.D.3 - Serine family Rv0506 mmpS2 51 27.7 26 51.4 12.9 26.9832479552939 0.596071388133034 0.590404143733609 1.00959892382121 0.312687485440455 0.510386669783453 Probable conserved membrane protein MmpS2 II.C.4 - Conserved membrane proteins Rv0507 mmpL2 62.9 55.6 29.9 54.9 23.8 267.092318370569 0.498444432746144 0.31467706549867 1.58398716460717 0.113196640013397 0.255015216502098 Probable conserved transmembrane transport protein MmpL2 II.C.4 - Conserved membrane proteins Rv0508 - 152.5 81.1 76.1 85.6 8.9 39.3123648899022 -0.456065369402959 0.554500980357742 -0.822478923497526 0.410804377274775 0.607037590449417 hypothetical protein VI - Unknowns Rv0509 hemA 581.9 287.8 318.6 311.9 90.6 814.271064756899 -0.251049615213313 0.255826848253399 -0.981326303033863 0.326431855785031 0.526272932722157 Probable glutamyl-tRNA reductase HemA (GLUTR) I.G.12 - Heme and porphyrin Rv0510 hemC 1005.5 555.9 587.8 233.1 105.1 813.881604398452 -1.25051755906344 0.270939749859376 -4.6154820756736 3.92183890225332e-06 5.62394874161184e-05 Probable porphobilinogen deaminase HemC (PBG) (hydroxymethylbilane synthase) (HMBS) (pre-uroporphyrinogen synthase) I.G.12 - Heme and porphyrin Rv0511 hemD 566.1 293.7 266.8 95 30.6 701.287207863068 -1.81191509974168 0.255780991701034 -7.08385360339643 1.40200017254594e-12 7.75919470493392e-11 Probable uroporphyrin-III C-methyltransferase HemD (uroporphyrinogen III methylase) (urogen III methylase) (SUMT) (urogen III methylase) (UROM) I.D.3 - Serine family Rv0512 hemB 540 342.6 255.4 101.9 27.5 415.387219945351 -1.8076097099384 0.27746046669083 -6.51483698379485 7.2768642085216e-11 2.83237945347071e-09 Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH) I.G.12 - Heme and porphyrin Rv0513 - 451 281 186.2 75.6 26.9 184.418699603332 -1.80583929563362 0.333014577603007 -5.42270344028723 5.87043420694406e-08 1.23035964266248e-06 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0514 - 191.3 84.9 59.5 19.6 12 35.0173465565633 -2.03007688758779 0.621637134148291 -3.26569436745315 0.00109196037082728 0.00668000627542353 Possible transmembrane protein II.C.5 - Other membrane proteins Rv0515 - 132 86.7 86.2 38 3.9 174.662173707876 -1.66604849321461 0.396336740361551 -4.20361859890856 2.62681415770383e-05 0.000297258011073066 Conserved 13E12 repeat family protein V - Conserved hypotheticals Rv0516c - 226.6 198.6 105.9 73.9 15.3 99.7943765892477 -1.26406964257975 0.411975213533412 -3.06831479432494 0.00215269719371901 0.0116962875729694 Possible anti-anti-sigma factor V - Conserved hypotheticals Rv0517 - 21.1 9.8 8 22.9 2.1 28.0236200549579 0.589607580749099 0.630848592915251 0.934626132753073 0.349981006578893 0.550947877912196 Possible membrane acyltransferase IV.H - Miscellaneous transferases Rv0518 - 30 18.2 7.5 14.3 0 14.675986576564 -0.646394804080157 0.877577996354122 -0.73656678581914 0.461385839521969 0.653430085400565 Possible exported protein VI - Unknowns Rv0519c - 29.5 33.6 10.4 8 6.6 29.5429138314449 -0.910691421280729 0.680509221219054 -1.33824993531951 0.180814976015957 0.353642542820828 Possible conserved membrane protein V - Conserved hypotheticals Rv0520 - 9.2 7.2 2.1 23.7 8.4 7.21613776730917 2.22685470331634 1.08979731868431 2.04336592239443 0.0410162282527696 NA Possible methyltransferase/methylase (fragment) IV.H - Miscellaneous transferases Rv0521 - 4 3.8 3.3 8.4 5.8 3.05524483497499 1.78915310837809 1.60833543962315 1.112425346293 0.265955311742074 NA Possible methyltransferase/methylase (fragment) ? Rv0522 gabP 30.7 38.4 10.1 22.9 8.7 54.3787410639743 0.0437820830892764 0.527983560211804 0.0829231938049604 0.933912611562595 0.970633353918636 Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease) III.A.1 - Amino acids Rv0523c - 35.6 16.2 13 23.5 10 14.6812077731674 0.40771979827328 0.77035896529151 0.529259496732144 0.596625448666595 0.761090484565671 hypothetical protein V - Conserved hypotheticals Rv0524 hemL 299.3 158.6 142.3 81.8 28.1 339.387918067314 -1.07626297824715 0.278049560393087 -3.87075950318212 0.00010849679064892 0.000970443516359783 Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) I.G.12 - Heme and porphyrin Rv0525 - 261 117.4 87.6 84.4 26.5 118.648474703406 -0.688362876202475 0.368434073143761 -1.86834749112328 0.061713651013087 0.162278954631295 hypothetical protein V - Conserved hypotheticals Rv0526 - 265.4 182.2 158.9 83.3 34.2 168.001644497038 -1.04213332372903 0.332365038330429 -3.13550826213245 0.00171556595847256 0.00969144278295025 Possible thioredoxin protein (thiol-disulfide interchange protein) V - Conserved hypotheticals Rv0527 ccdA 164.4 80.5 74.3 16.7 7.6 86.9299904983517 -2.37151195907924 0.437778991755828 -5.41714427539721 6.05584734512153e-08 1.26175360567179e-06 Possible cytochrome C-type biogenesis protein CcdA I.B.6.a - aerobic Rv0528 - 175 89.7 124.8 21.5 3.7 218.182790229651 -2.6704265824369 0.388531227394691 -6.87313243865503 6.28072045156835e-12 2.88913140772144e-10 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0529 ccsA 170.3 104.2 106.3 28.9 5.5 133.700059592313 -2.18932604804295 0.395076501409197 -5.54152433828347 2.99849889280023e-08 6.76476629190982e-07 Possible cytochrome C-type biogenesis protein CcsA I.B.6.a - aerobic Rv0530 - 144.4 79.6 52.6 42.2 5 125.545001899819 -1.25317424355856 0.408714138582387 -3.0661387147143 0.00216842689171316 0.0117619725121716 hypothetical protein V - Conserved hypotheticals Rv0530A - 187.8 174.8 94.8 169.9 12.5 34.119580618259 -0.171640264926412 0.625232109581548 -0.274522473008122 0.783683135784592 0.885336132396263 hypothetical protein ? Rv0531 - 133.8 87.4 47.9 68.8 24 40.8346891149702 -0.156474736766324 0.509161438505532 -0.307318514193851 0.758600944822088 0.874152454138993 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0532 PE_PGRS6 14.3 6.4 6.8 3.3 0.6 16.8247075864453 -1.64516419945643 0.839630208476384 -1.95939138783702 0.0500669684761898 0.140298419574893 PE-PGRS family protein PE_PGRS6 IV.C.1.b - PE_PGRS subfamily Rv0533c fabH 49.4 26.4 20.8 38.8 9.9 53.1943645950893 0.34449541977956 0.451905709909052 0.762317032570559 0.445870810649223 0.640538218153687 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) I.H.1 - Synthesis of fatty and mycolic acids Rv0534c menA 12.3 6.1 10.5 9 4.8 14.8298012763025 0.176495554210591 0.792110450782551 0.222816848377932 0.823678054520961 0.906045859973057 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0535 pnp 20.8 10.1 5.4 5.1 2.5 10.5589570987289 -1.00912607683213 0.95125897704163 -1.06083211952487 0.288766202432932 0.484973868666403 Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv0536 galE3 12.3 9.5 5.4 3.8 0 9.77557670830404 -1.39480192797907 1.0324821664229 -1.3509210844885 0.17672071334308 0.347342599258077 Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.A.1 - Carbon compounds Rv0537c - 66.8 41 25.7 39.2 6.9 87.8631063773894 -0.238534780974999 0.408070010383174 -0.584543766769377 0.558854528313295 0.732862917173524 Probable integral membrane protein II.C.5 - Other membrane proteins Rv0538 - 33.1 23.3 25.1 13.4 8.7 67.1784486278118 -0.512522447760553 0.470054572643295 -1.09034669076496 0.275560455105419 0.471577094280145 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv0539 - 31.8 16.6 21.2 13.6 3.6 18.0978084572253 -0.845859034616841 0.744918492847319 -1.13550548514871 0.256163584982018 0.448286273718532 Probable dolichyl-phosphate sugar synthase (dolichol-phosphate sugar synthetase) (dolichol-phosphate sugar transferase) (sugar phosphoryldolichol synthase) IV.H - Miscellaneous transferases Rv0540 - 12.7 0.6 3.9 5.6 1.7 4.23439578401002 -0.266852976246787 1.56185448912738 -0.170856490220084 0.864336609286615 NA hypothetical protein V - Conserved hypotheticals Rv0541c - 81.2 54.8 37.4 18 0.1 81.0356698356759 -2.28342692573686 1.04549833813297 -2.18405600702777 0.0289581328224105 0.0922777125619633 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0542c menE 152.7 79.8 70.1 63.5 25.7 154.959569810802 -0.379442787425005 0.327116195419477 -1.15996331804491 0.246063741213477 0.435778885689068 Possible O-succinylbenzoic acid--CoA ligase MenE (OSB-CoA synthetase) (O-succinylbenzoate-CoA synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0543c - 265.1 155.4 123.5 238.2 55.1 94.0951508725842 0.418670845653592 0.372840136837049 1.12292321638261 0.261470106393888 0.455345779254933 hypothetical protein V - Conserved hypotheticals Rv0544c - 166.7 130.7 82.4 69.8 28.1 47.6640824897741 -0.637797764286458 0.486237941107123 -1.31169888313167 0.189621753766134 0.365021875999807 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0545c pitA 392.1 293.5 200.5 169.1 59.8 506.240529074238 -0.598226887720235 0.263883846064782 -2.26700836993779 0.0233897144182021 0.0784530004443862 Probable low-affinity inorganic phosphate transporter integral membrane protein PitA III.A.4 - Anions Rv0546c - 81.7 82.7 31.4 18.4 15.3 32.1294738621616 -1.11253208426171 0.649634356104579 -1.7125511817645 0.0867951409848616 0.210135604489665 hypothetical protein V - Conserved hypotheticals Rv0547c - 40.2 19.9 9 24.2 8.9 32.6508147806884 0.333089077019569 0.576349007106878 0.577929471400652 0.563311736969689 0.73658247083737 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0548c menB 120.9 71.8 63.1 73.7 19 119.019816310976 -0.151683471382469 0.348075031454329 -0.435778087123067 0.662997743982437 0.811587316217242 Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0549c vapC3 42.3 21.3 27.7 49.4 28.6 31.6500101532867 1.22793919887603 0.576353690612262 2.13053064268849 0.0331278287561092 0.101856570706718 Possible toxin VapC3 V - Conserved hypotheticals Rv0550c vapB3 24.1 4 4.7 39.4 15 9.59442686604504 2.17882569737162 1.02140997600249 2.1331549021079 0.0329120212422849 0.101811684925916 Possible antitoxin VapB3 VI - Unknowns Rv0551c fadD8 22 15.1 8.7 10.4 1.1 31.5345393855369 -0.756574360448896 0.621410332123979 -1.21751171703716 0.223409581142894 0.407685078005219 Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0552 - 29.1 13.2 17.3 15.6 7.4 51.513570398963 0.00535517298221682 0.479691494975753 0.0111637855544792 0.991092772884464 0.996155108273772 hypothetical protein I.J.1 - Repressors/activators Rv0553 menC 13.8 4.1 8.9 4.1 0 9.11791062185857 -1.33771665449575 1.09733236851711 -1.21906242162845 0.222820501326676 0.406819698813962 Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0554 bpoC 51.5 28.9 22.7 18.9 3.9 32.5331438006322 -0.873654086043063 0.577722982309085 -1.51223702846506 0.130473574262904 0.28172463752718 Possible peroxidase BpoC (non-haem peroxidase) III.F - Detoxification Rv0555 menD 178 80.9 68.1 53.8 17.7 225.343156313651 -0.812243103712256 0.309938638042434 -2.62065778194796 0.0087760308881174 0.0358118679789307 Probable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0556 - 173.9 161 97.3 96.2 39.2 110.899907728062 -0.320490534590871 0.378872091898036 -0.845906947078919 0.397604656708074 0.597250082298557 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0557 mgtA 100.5 72 46.9 45.1 8.1 104.634168302363 -0.782002196356723 0.395867866675939 -1.97541215689749 0.0482213943168959 0.136598145413889 Mannosyltransferase MgtA V - Conserved hypotheticals Rv0558 menH 216.1 139.3 88.9 97.1 22 136.490991683635 -0.573857345191857 0.349553639449507 -1.64168608313046 0.100655077269002 0.234091231264044 Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0559c - 916.9 702.8 393.3 466.6 147.2 321.961651338662 -0.364711470915683 0.291723032828097 -1.25019772137977 0.211227329000638 0.391676575290697 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv0560c - 42.6 31.7 34.9 20.5 0 31.2174993013188 -1.2272161863121 0.686056316351443 -1.78879802876625 0.0736473485267321 0.184917396204812 Possible benzoquinone methyltransferase (methylase) IV.H - Miscellaneous transferases Rv0561c - 23.7 14.1 11.4 17.3 4.8 32.0814584364025 0.212053972670103 0.545408384823762 0.388798519734206 0.69742519593073 0.832304597030542 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0562 grcC1 139.3 78.4 58.8 107.2 23.1 147.343745908909 0.201606826898965 0.338288268586005 0.595961626874181 0.551200861996555 0.727404416241356 Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0563 htpX 105.1 48.8 66.7 84.1 23.1 105.987183018515 0.234921439912416 0.38000208024134 0.618210931274948 0.536436305266207 0.715922152695141 Probable protease transmembrane protein heat shock protein HtpX III.B - Chaperones/Heat shock Rv0564c gpdA1 23.2 10.8 5.8 13.6 6.6 22.7713353215385 0.440268586556326 0.657204599888232 0.669910993671074 0.502914531127556 0.687769602028496 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA1 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0565c - 14.7 9.3 9.5 14 11 39.387762221586 1.04240130353388 0.550417006190013 1.89383920157078 0.058246356513155 0.157127642627262 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0566c - 26.3 11.4 13.3 18.6 13 17.1350197044065 0.714335131908956 0.742561795407149 0.961987455222208 0.33605590549503 0.537143509595396 hypothetical protein V - Conserved hypotheticals Rv0567 - 64.1 27.8 25.5 67.3 34.5 97.0771355675059 1.2656701138251 0.389077135482338 3.25300563410402 0.00114191233021663 0.00694957641516717 Probable methyltransferase/methylase IV.H - Miscellaneous transferases Rv0568 cyp135B1 249.2 122.4 148.4 124.2 48.6 369.130119308478 -0.210638294343373 0.291984356321254 -0.721402670325323 0.470661804137921 0.661541313593856 Possible cytochrome P450 135B1 Cyp135B1 IV.F - Cytochrome P450 enzymes Rv0569 - 613.3 294.1 686.5 2772.7 1157.9 740.813484871307 2.62337668751496 0.375068393996104 6.99439550095017 2.66405060141991e-12 1.36754597539555e-10 hypothetical protein V - Conserved hypotheticals Rv0570 nrdZ 185.8 63.3 147.7 895.1 212.7 1399.74760937789 2.66551091640288 0.35292854645091 7.55255119827389 4.26813773354515e-14 3.14952996921186e-12 Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv0571c - 61 11.3 35.9 169.3 41.1 182.128709117028 2.22120733257647 0.422281341795324 5.26001770083668 1.44041534998656e-07 2.78795145882644e-06 hypothetical protein V - Conserved hypotheticals Rv0572c - 84.4 45.4 64.8 937.3 393.8 279.527730015453 4.17619837497348 0.328579324014207 12.7098635542658 5.21253113667618e-37 6.15426176203567e-34 Hypothetical protein VI - Unknowns Rv0573c pncB2 18.5 5.1 13.5 88.9 34.3 110.950308130049 3.0906678189381 0.415466782183246 7.43902509533224 1.01431055968677e-13 6.7786566083218e-12 Nicotinic acid phosphoribosyltransferase PncB2 V - Conserved hypotheticals Rv0574c - 87.9 38.1 62.6 256.1 59.1 245.078515505016 1.95114286159961 0.339598752501027 5.74543589229971 9.16844894725793e-09 2.27095427770542e-07 hypothetical protein V - Conserved hypotheticals Rv0575c - 19.9 8.9 6.9 25.3 16.9 43.1084999695687 1.75036497631795 0.529072496712504 3.30836508643747 0.000938423872291481 0.00583937151466986 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0576 - 74.7 42.8 34.7 99.4 31.9 151.806332220128 1.1437160335434 0.315666633123663 3.62317683762079 0.000291006721613805 0.00222623284655745 Probable transcriptional regulatory protein (possibly ArsR-family) I.J.1 - Repressors/activators Rv0577 TB27.3 101 62.5 46.6 173.9 27.2 121.705431931672 1.15732134032728 0.375199468449726 3.08454952004376 0.00203860669507272 0.0112061385276325 Conserved protein TB27.3 V - Conserved hypotheticals Rv0578c PE_PGRS7 136.2 75.9 85.3 70.9 25.1 576.363920807413 -0.287751717768436 0.268853851380754 -1.07029048046226 0.284488578003167 0.480916121351566 PE-PGRS family protein PE_PGRS7 IV.C.1.b - PE_PGRS subfamily Rv0579 - 101.2 72.2 32.7 84.7 21.5 86.4565004856586 0.370634643232727 0.407982808219539 0.9084565225927 0.363637074451807 0.564913384959781 hypothetical protein V - Conserved hypotheticals Rv0580c - 70.5 57.3 27.6 78.1 4 38.3014528355236 0.200407770324332 0.619866812888225 0.323307791540809 0.746462153808186 0.865456284382519 hypothetical protein VI - Unknowns Rv0581 vapB26 109.8 64.9 15.6 59.3 17.9 19.7061270633901 0.132206488118873 0.73761567584541 0.179234921990162 0.8577532439112 0.922892463527786 Possible antitoxin VapB26 V - Conserved hypotheticals Rv0582 vapC26 37.2 38 20.9 18.3 9.9 19.0501100785668 -0.48942987450022 0.721934777855767 -0.677941954748164 0.497808497315458 0.684221070039329 Possible toxin VapC26 Contains PIN domain VI - Unknowns Rv0583c lpqN 9 11 9.4 6.6 8 13.5113123771292 0.290555991223252 0.886698180162516 0.327683080583292 0.743151297433941 0.86306318073778 Probable conserved lipoprotein LpqN II.C.1 - Lipoproteins(lppA-lpr0) Rv0584 - 11.7 9.3 7 6.8 1.9 34.7063420506183 -0.365755267426194 0.543179782047953 -0.673359501797333 0.500718606648741 0.686356542085852 Possible conserved exported protein VI - Unknowns Rv0585c - 7.2 2.9 3.6 4.6 2.5 19.9083542522227 0.47158829726908 0.69277188597367 0.680726667489223 0.496044459061537 0.683456496189807 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0586 mce2R 100.2 51 55.7 79.9 20.7 82.1773905183093 0.254358128016358 0.394210123903955 0.645234895282217 0.518774975854716 0.701655105911572 Probable transcriptional regulatory protein Mce2R (GntR-family) I.J.1 - Repressors/activators Rv0587 yrbE2A 95.9 67.4 52.3 57.4 4.8 74.1841460810881 -0.602433496437477 0.475157574424314 -1.26786045064601 0.204847789845216 0.38471414190443 Conserved hypothetical integral membrane protein YrbE2A IV.A - Virulence Rv0588 yrbE2B 67.7 66.4 38.3 33.9 4 63.6045507966191 -0.930925808585252 0.492135717963745 -1.89160382919785 0.058543785328619 0.157569975405751 Conserved hypothetical integral membrane protein YrbE2B IV.A - Virulence Rv0589 mce2A 64.5 69.3 45 34.1 3.5 89.6446109792743 -1.10159878714739 0.477300094829667 -2.30797940138796 0.0210002821999776 0.0722165044197287 Mce-family protein Mce2A IV.A - Virulence Rv0590 mce2B 62.5 85.1 27.2 23.6 11.9 63.8144113968473 -0.939414739135186 0.523419314399201 -1.79476514009324 0.0726911270770756 0.183216010102248 Mce-family protein Mce2B IV.A - Virulence Rv0590A - 35.1 40.9 8.2 23.6 2.8 8.57967157095761 -0.541535748819967 1.11310938183253 -0.486507218121215 0.626607588890464 0.782596643106496 Mce-family related protein ? Rv0591 mce2C 10.1 9.7 2.7 2.6 0.9 12.2983369810642 -1.3176829049742 0.921273247827655 -1.43028456332719 0.152635363424854 0.314505210733468 Mce-family protein Mce2C IV.A - Virulence Rv0592 mce2D 6.8 3.7 3.7 2.1 3.2 12.6739835198018 0.0938804730144965 0.914080227628093 0.102704850380697 0.91819722395841 0.96050046286494 Mce-family protein Mce2D IV.A - Virulence Rv0593 lprL 12.2 3 8.1 1.1 0 9.02531088535606 -2.9425686374666 1.19911850080128 -2.45394315532644 0.0141299315855943 0.052626937619532 Possible Mce-family lipoprotein LprL (Mce-family lipoprotein Mce2E) II.C.1 - Lipoproteins(lppA-lpr0) Rv0594 mce2F 14.4 12.7 7.2 5.8 0 19.8634251013372 -1.26982615159265 0.786425264996938 -1.61468127756245 0.106379734049263 0.243408926358197 Mce-family protein Mce2F IV.A - Virulence Rv0595c vapC4 37.7 28.6 19.5 22.3 10 16.9572825267327 -0.0436061496454296 0.727266282691738 -0.0599589870769695 0.952188299460587 0.978748655233813 Possible toxin VapC4 V - Conserved hypotheticals Rv0596c vapB4 38.5 22.1 30.9 12.3 0 8.47135897114722 -1.60765831301075 1.11905626421181 -1.43661973434649 0.150826073088413 0.311865703957478 Possible antitoxin VapB4 V - Conserved hypotheticals Rv0597c - 123.2 61.6 53.4 27.2 2.4 103.703697717418 -1.72949029479516 0.452248614749592 -3.82420252575627 0.00013119604110292 0.00113896170977094 hypothetical protein V - Conserved hypotheticals Rv0598c vapC27 186.4 124 84.1 63.3 20.2 68.6437041033885 -0.880278091893935 0.423982494663249 -2.07621329411985 0.0378742282731063 0.113976649569535 Possible toxin VapC27 Contains PIN domain V - Conserved hypotheticals Rv0599c vapB27 236 121.9 76.9 115.2 4.2 39.6609527251517 -0.68642327218177 0.639411708400605 -1.07352315130225 0.283036456950902 0.479672311253634 Possible antitoxin VapB27 V - Conserved hypotheticals Rv0600c - 0 0 0 0 0 0 NA NA NA NA NA Two component sensor kinase [second part] I.J.2 - Two component systems Rv0601c - 0 2.6 0 0 0 0.374079217145335 -0.186785519319731 4.45675302151425 -0.0419106731779962 0.966569907909474 NA Two component sensor kinase [first part] I.J.2 - Two component systems Rv0602c tcrA 1.8 0 1.4 0.5 0 0.644712741018434 -0.466300288665021 3.19588606732568 -0.145906418076794 0.883995264922347 NA Two component DNA binding transcriptional regulatory protein TcrA I.J.2 - Two component systems Rv0603 - 1.5 0 0 2 0 0.269588662725155 1.44594992034034 4.41723977225191 0.327342411753028 0.743408917832161 NA Possible exported protein VI - Unknowns Rv0604 lpqO 23 14.5 16.6 7.7 7.8 26.690532809781 -0.446543774288872 0.673312346488034 -0.663204494345045 0.507199593456387 0.691760092422997 Probable conserved lipoprotein LpqO II.C.1 - Lipoproteins(lppA-lpr0) Rv0605 - 130.3 129.5 52.4 29.2 3.2 67.0550474778987 -2.01055008377353 0.544129136295796 -3.69498699786693 0.000219898039799013 0.00175028956622046 Possible resolvase IV.B.1.c - Others Rv0606 - 89.2 67.4 54.3 29.6 10.6 65.5064670047586 -1.09925881968171 0.440851938150021 -2.49348755115971 0.012649501991103 0.048228779389114 Possible transposase (fragment) IV.B.1.c - Others Rv0607 - 31.3 13.3 15.7 12.9 0 8.76056057142853 -0.902684690747505 1.05981767379546 -0.851735834442894 0.3943607268614 0.594614104267602 Hypothetical protein VI - Unknowns Rv0608 vapB28 274.3 183.6 136 291.8 69.7 88.6848093966064 0.576938079269078 0.379514101321421 1.52020195629161 0.128460225899963 0.278734800453166 Possible antitoxin VapB28 V - Conserved hypotheticals Rv0609 vapC28 223 102.2 76.2 175.6 46.6 91.3795921047804 0.497551243470904 0.387509477511276 1.28397180545455 0.199151820757286 0.376411819168786 Possible toxin VapC28 Contains PIN domain V - Conserved hypotheticals Rv0609A - 226.2 95.8 84.8 132.4 58.4 52.2947784248681 0.320152089328853 0.466248248762054 0.686655853783679 0.492299622469294 0.680345401009067 hypothetical protein ? Rv0610c - 43 23 26.7 28.1 17.4 67.2083939880719 0.42022761839387 0.451507310711644 0.930721626038628 0.351997579981845 0.552648682755184 Hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0611c - 235.9 115.7 72.4 190.7 15.4 79.5891693576292 0.178899052685494 0.480270708858373 0.372496280505522 0.709523380807345 0.842090458521737 Hypothetical protein VI - Unknowns Rv0612 - 18.7 4 5.4 27.9 5.3 13.0848903896049 1.48258134075843 0.858970403686704 1.72599816523967 0.0843477428221582 0.206325763174091 hypothetical protein VI - Unknowns Rv0613c - 75 40.3 36.9 29.4 13.1 183.385912499593 -0.434279493322509 0.320071409106651 -1.35682063741533 0.174838208460841 0.344506798974102 hypothetical protein VI - Unknowns Rv0614 - 0.8 1.7 0 0.9 0 0.778462211233068 0.62647564444206 2.980809067566 0.210169665430337 0.833535254282601 NA hypothetical protein V - Conserved hypotheticals Rv0615 - 76.4 56.7 33.3 68.5 56.3 32.3396239997841 1.10075872757159 0.59243718601474 1.85801761529568 0.063166512839621 0.165485050649362 Probable integral membrane protein II.C.5 - Other membrane proteins Rv0616c - 4.5 11.5 0 4.7 0 1.79620930824889 -0.272078395201265 2.19459102030367 -0.123976810569296 0.901333635876873 NA Hypothetical protein VI - Unknowns Rv0616A vapB29 332.4 164.4 156.1 134.2 82.6 75.6485620425017 -0.177263813273065 0.427491816612091 -0.414660132392464 0.678390721396896 0.820589432842296 Possible antitoxin VapB29 ? Rv0617 vapC29 222.9 107.1 137.9 70.4 35.8 84.6946596710264 -0.77682601278595 0.424470737971978 -1.83010498320201 0.0672342419439147 0.173195407247524 Possible toxin VapC29 Contains PIN domain V - Conserved hypotheticals Rv0618 galTa 34.5 20.9 11.4 18.4 1.2 18.2913749689242 -0.578484006054503 0.799754727621326 -0.723326772665742 0.469479148180612 0.660928117192261 Probable galactose-1-phosphate uridylyltransferase GalTa [first part] I.A.1 - Carbon compounds Rv0619 galTb 3.4 0 1.9 1.2 3.6 2.14591923105109 0.860124867124635 2.01913144245535 0.425987555361272 0.670116914113575 NA Probable galactose-1-phosphate uridylyltransferase GalTb [second part] I.A.1 - Carbon compounds Rv0620 galK 1 0 1.3 0 0 0.797656165807235 -1.82947535364364 3.19131176582134 -0.573267511258898 0.566463579528625 NA Probable galactokinase GalK (galactose kinase) I.A.1 - Carbon compounds Rv0621 - 22.4 4.8 5.5 23.8 7.4 26.1473371450026 1.27883957374552 0.645046413119109 1.98255435227012 0.0474172305261798 0.135009510067306 Possible membrane protein II.C.5 - Other membrane proteins Rv0622 - 8.6 5.8 0.2 11.3 0 7.29625124514338 0.893189883234602 1.26935685668145 0.703655460269635 0.481647364057085 0.669542764321112 Possible membrane protein II.C.5 - Other membrane proteins Rv0623 vapB30 185.8 34.8 56.4 165.3 21.2 39.3802821403984 0.694429417276901 0.607977721764411 1.14219549897585 0.253372766486122 0.445161874451312 Possible antitoxin VapB30 V - Conserved hypotheticals Rv0624 vapC30 190.7 120.7 85.9 158.8 37.8 85.8752642148342 0.289822109829308 0.386244172339375 0.7503598256873 0.453038020031008 0.647301600221795 Possible toxin VapC30 Contains PIN domain V - Conserved hypotheticals Rv0625c - 25.5 7 4.4 7.5 1.4 9.23696886985331 -0.909547315532052 1.08121116000835 -0.841230047537638 0.400219070442113 0.599442325641651 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0626 vapB5 114.9 75.1 29.9 40.1 8.8 21.8836249098961 -0.93477513076738 0.715498690746418 -1.30646658457503 0.19139393537595 0.366838376137238 Possible antitoxin VapB5 V - Conserved hypotheticals Rv0627 vapC5 97 34.5 42.4 36.7 13.9 31.2412163183388 -0.455153600173167 0.58081329103216 -0.783648733940499 0.43324625169158 0.628402220922021 Possible toxin VapC5 V - Conserved hypotheticals Rv0628c - 62.2 19.8 26.4 58.9 12.6 76.3524288825267 0.697476611012722 0.430948269594756 1.61846945497332 0.105561464386979 0.242330484327464 hypothetical protein V - Conserved hypotheticals Rv0629c recD 21.9 13.8 10.2 4 0 26.9111492508295 -2.10625777380323 0.7173446862337 -2.93618648639022 0.00332274502800932 0.0164667078960714 Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0630c recB 16 7.1 5.2 2.1 0.6 30.676900106709 -2.07321248926363 0.643300967605657 -3.22277222274366 0.00126956465792327 0.00762169155654952 Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0631c recC 8.2 1.6 3.9 2.7 0.9 18.8233385049633 -0.630111860452225 0.757137856351197 -0.832228708638164 0.405279862183783 0.603696932605714 Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0632c echA3 451.9 334.9 250.5 236.1 110.1 369.863711322055 -0.170045216024966 0.288006789811992 -0.590420858258133 0.554908530056258 0.730198914488785 Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0633c - 97.9 50.4 54.3 44.9 14.6 78.8588476801357 -0.431508116129714 0.401953205888762 -1.07352823614282 0.283034176795461 0.479672311253634 Possible exported protein VI - Unknowns Rv0634c - 227.1 138.8 103.4 175.3 52.5 186.959645119318 0.296847794029001 0.302466957041794 0.981422225198581 0.326384570554177 0.526272932722157 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) III.F - Detoxification Rv0634A - 421.8 259.6 176.9 299.6 60.4 108.098662380563 0.0220838555215095 0.374189888541661 0.059017777331123 0.952937948529018 0.979180506404631 hypothetical protein ? Rv0634B rpmG2 215.2 210.1 147.6 389.7 154.9 82.6681613869352 1.29856912616306 0.406631545838185 3.19347856666246 0.00140569772326222 0.00822972121618972 50S ribosomal protein L33 RpmG2 ? Rv0635 hadA 292.7 187.6 137.3 274.8 113.5 195.13208133626 0.73736496897747 0.304282792060831 2.42328842845001 0.0153807095176656 0.0564765626706628 (3R)-hydroxyacyl-ACP dehydratase subunit HadA V - Conserved hypotheticals Rv0636 hadB 318.8 148.4 176.8 281.8 68.3 159.125090801504 0.395970773719155 0.336992419238452 1.17501389085839 0.23998915846156 0.427156582548164 (3R)-hydroxyacyl-ACP dehydratase subunit HadB VI - Unknowns Rv0637 hadC 366.1 210.7 173.7 280.1 113.1 226.161463212333 0.463892327725246 0.29290874752787 1.58374350933684 0.113252099254037 0.255015216502098 (3R)-hydroxyacyl-ACP dehydratase subunit HadC V - Conserved hypotheticals Rv0638 secE1 1000.2 429.6 464.9 1287.8 395.3 708.675832009804 1.18832530390832 0.258727968081815 4.59295263947863 4.3701826954656e-06 6.19167484293567e-05 Probable preprotein translocase SecE1 III.D - Protein and peptide secretion Rv0639 nusG 1027.1 591.2 597.7 1111.8 426.1 1114.8732374926 0.860133428878301 0.24504503141222 3.51010352636518 0.0004479322578696 0.00316681847779266 Probable transcription antitermination protein NusG II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0640 rplK 1165.4 823.3 764.7 1323.3 785.7 946.833357148807 1.13652418689002 0.298528674011096 3.80708550243913 0.000140614140553224 0.00120303209139981 50S ribosomal protein L11 RplK II.A.1 - Ribosomal protein synthesis and modification Rv0641 rplA 1348.3 745.5 612.4 813.1 225.9 965.383107051703 -0.0583716352110918 0.236973906227925 -0.246320939466428 0.805433801864063 0.897686131592986 50S ribosomal protein L1 RplA II.A.1 - Ribosomal protein synthesis and modification Rv0642c mmaA4 255.3 206.3 107.3 159.9 64.2 274.445516612117 0.0669971645854367 0.30893665502545 0.216863759918413 0.82831452088271 0.908325087605746 Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0643c mmaA3 111.1 52 49.9 83.7 45.5 125.467419058513 0.747548132663046 0.363941427410066 2.05403418342028 0.039972383337902 0.118976623346932 Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0644c mmaA2 47.6 42.1 19.9 53.8 17.6 61.1499922448132 0.729035282671894 0.442841456632805 1.6462670144191 0.0997087974810874 0.232487594610968 Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0645c mmaA1 53.3 37.5 20.6 43.1 39.3 78.3244739759998 1.19246088141862 0.472978155948458 2.52117537865441 0.0116963540566138 0.0452770339546733 Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) I.H.2 - Modification of fatty and mycolic acids Rv0646c lipG 87.3 60 34.9 20 3.6 59.4662796950232 -1.64068670189514 0.495938321717422 -3.30824747765706 0.000938818081754571 0.00583937151466986 Probable lipase/esterase LipG II.B.5 - Esterases and lipases Rv0647c - 101.4 59.4 34.9 19.7 4.4 102.689371416099 -1.66127731667888 0.408814654480493 -4.06364424188748 4.83124436262974e-05 0.000488921929498129 hypothetical protein V - Conserved hypotheticals Rv0648 - 5.6 3.1 2.2 2.9 1.1 19.0526164771618 -0.096574714856514 0.690518198754311 -0.139858319492135 0.888771933760571 0.943105027107524 Alpha-mannosidase V - Conserved hypotheticals Rv0649 fabD2 2.9 2.6 0 2.4 0 1.30627890171218 0.493547526572319 2.43440100286866 0.202738795289162 0.839339198557393 NA Possible malonyl CoA-acyl carrier protein transacylase FabD2 (MCT) I.H.1 - Synthesis of fatty and mycolic acids Rv0650 - 0.7 0 0 0.9 0 0.379696254809457 1.60190632026165 4.29252632779212 0.373184972655857 0.709010779723359 NA Possible sugar kinase I.J.1 - Repressors/activators Rv0651 rplJ 119.8 80.7 57.2 75.6 32 74.8728643225957 0.119991939258828 0.401942786042057 0.298529898845535 0.765298759866327 0.876096305656509 50S ribosomal protein L10 RplJ II.A.1 - Ribosomal protein synthesis and modification Rv0652 rplL 99.4 37.6 60 58.9 29.5 43.6498872473817 0.185078825578217 0.51502425343477 0.359359436655459 0.719326215623841 0.848914653385803 50S ribosomal protein L7/L12 RplL (SA1) II.A.1 - Ribosomal protein synthesis and modification Rv0653c - 7 6.8 1.6 6.9 2.8 5.73624581857004 0.697092824926931 1.21647205730311 0.573044666946455 0.566614450966881 NA Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv0654 - 24.1 15.4 10.5 43.7 14 67.7745433437017 1.5616554380704 0.408733682550228 3.82071628725752 0.000133064653688972 0.00115086202926672 Probable dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0655 mkl 1706.8 1245.8 956.3 1344.9 609.9 2570.6033235454 0.445345505799516 0.249163109103297 1.78736534233439 0.0738784593529618 0.18519285423085 Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl II.C.5 - Other membrane proteins Rv0656c vapC6 58.5 23.6 19.2 36.6 5.1 17.1576905041486 -0.00987347450274961 0.765502312088217 -0.0128980335484758 0.98970914349764 0.996155108273772 Possible toxin VapC6 I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0657c vapB6 213.7 102.8 79.3 184.8 17.6 30.8163036747317 0.27519235151761 0.608926026906705 0.451930676892832 0.65131892385477 0.802424914189076 Possible antitoxin VapB6 V - Conserved hypotheticals Rv0658c - 64.3 16.1 25.7 42.6 3.3 35.2724873803218 0.0385271665300987 0.619152751808322 0.0622256243189984 0.950383156770843 0.977994521000095 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0659c mazF2 1190.1 507.5 408.5 585.5 132.6 299.094224332819 -0.222684134545528 0.310954115703544 -0.716131812700718 0.473909961923764 0.663395108793737 Toxin MazF2 V - Conserved hypotheticals Rv0660c mazE2 1025.8 469.9 481.6 408.6 275.4 257.463976925272 0.0426109551854425 0.347495851986967 0.122622917487489 0.902405705867827 0.951569220060685 Possible antitoxin MazE2 V - Conserved hypotheticals Rv0661c vapC7 9.1 3.2 2.3 1.8 0 1.75742866717616 -1.09233547151159 2.07054559984441 -0.527559244091834 0.597805286714044 NA Possible toxin VapC7 V - Conserved hypotheticals Rv0662c vapB7 14.1 28.5 0 1.6 7.7 4.76161623128516 -1.73537972235599 1.67695267701359 -1.03484120103285 0.300743078053289 NA Possible antitoxin VapB7 VI - Unknowns Rv0663 atsD 79.2 49.4 40.6 49.3 19.4 214.803569437108 0.076265829211073 0.296839352669233 0.256926275189852 0.79723568659661 0.894742966389477 Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) I.C.5 - Sulphur metabolism Rv0664 vapB8 36.6 24.1 14.7 16.1 0.4 7.57080265469269 -0.908251136373309 1.12456362595081 -0.807647620298396 0.419293464903793 0.614454883197863 Possible antitoxin VapB8 VI - Unknowns Rv0665 vapC8 17.5 12.5 10.4 12.5 0 5.64618385023273 -0.390217684491832 1.25310500513184 -0.31140062715716 0.755496077186532 NA Possible toxin VapC8 V - Conserved hypotheticals Rv0666 - 21.4 8.6 6.9 9.8 0 2.04973859984371 -0.185759130103986 1.94338643064504 -0.0955852769036416 0.923849958981998 NA Possible membrane protein VI - Unknowns Rv0667 rpoB 636.5 351.1 396.7 1384.3 486.4 5122.23806562563 1.78566205501739 0.240795743649494 7.41567117405791 1.21010399283211e-13 7.93738581965062e-12 DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0668 rpoC 469.7 312.7 249.6 131.4 24.7 1574.07144390729 -1.54394593854519 0.271453151381685 -5.68770681307832 1.28756626973647e-08 3.10242158326979e-07 DNA-directed RNA polymerase (beta' chain) RpoC (transcriptase beta' chain) (RNA polymerase beta' subunit) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0669c - 18 9.8 4 9.7 2.1 27.5881827927216 -0.0681199897017105 0.632503521563966 -0.107698988826612 0.914234471648463 0.95801370906451 Possible hydrolase V - Conserved hypotheticals Rv0670 end 348.7 180.8 135.7 241.5 94.6 293.890140364215 0.446437074501588 0.284300973715809 1.57029738121071 0.116345943157928 0.260821095357835 Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) II.B.2 - DNA Rv0671 lpqP 157.1 96.9 68.6 152.1 52.7 175.852885043201 0.725796614275175 0.306559790516978 2.36755320406242 0.0179061452842485 0.063935046972589 Possible conserved lipoprotein LpqP II.C.1 - Lipoproteins(lppA-lpr0) Rv0672 fadE8 100.5 65.9 44.8 53.4 20.9 172.758073111422 -0.124495070718114 0.315965002886697 -0.394015380123467 0.693569684173251 0.830220960237125 Probable acyl-CoA dehydrogenase FadE8 I.A.3 - Fatty acids Rv0673 echA4 60.1 32.2 27.1 15.5 3 41.8157929699778 -1.36491910487162 0.536012023296139 -2.54643374691153 0.0108829868016817 0.0426410832428722 Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0674 - 41.4 42 26.1 12.1 2.7 29.8933262270025 -1.67617251153067 0.645141917711971 -2.59814540880447 0.00937287939294438 0.0376402934351576 hypothetical protein VI - Unknowns Rv0675 echA5 21.9 17 12 9.4 2.5 16.4740335650443 -0.881949131786719 0.767457492117882 -1.14918303729485 0.25048051385351 0.442053801728517 Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0676c mmpL5 123.4 80.4 80.4 89.7 29.2 447.217831106401 0.0498832640521348 0.270957669924493 0.184099841373878 0.853935130917701 0.920462030952677 Probable conserved transmembrane transport protein MmpL5 II.C.4 - Conserved membrane proteins Rv0677c mmpS5 302.4 167.9 163.7 213.7 83.2 155.813540701769 0.28094269413937 0.323254712812169 0.869106258947617 0.384789013608423 0.585699478384629 Possible conserved membrane protein MmpS5 II.C.4 - Conserved membrane proteins Rv0678 - 170.6 129.5 97.9 146.7 28.7 104.005067666507 0.0741426625330284 0.37901055677842 0.195621629020677 0.844906329845773 0.915606208783323 hypothetical protein VI - Unknowns Rv0679c - 105.1 67.4 46.8 112.4 44.4 76.3245366558025 0.896681022009529 0.393355601920211 2.27956845569829 0.0226332956061619 0.0765684174183624 Conserved threonine rich protein II.C.5 - Other membrane proteins Rv0680c - 78.9 24.4 54.9 50.4 12.2 28.9991954170934 -0.129243131955606 0.634839503771104 -0.203583947104535 0.838678638780846 0.91350881138875 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0681 - 56.5 24.3 17 36.7 9.5 29.0493801054095 0.264261172477089 0.592382265274974 0.446099061312079 0.655525690844458 0.805868918214254 Probable transcriptional regulatory protein (possibly TetR-family) I.J.1 - Repressors/activators Rv0682 rpsL 689.8 378.7 469 634.7 354.4 413.32776440456 0.847993621152745 0.319107758380885 2.65738954594951 0.00787483907723284 0.0334826906225911 30S ribosomal protein S12 RpsL II.A.1 - Ribosomal protein synthesis and modification Rv0683 rpsG 579.9 372.3 390.2 706.8 344.5 497.31377098571 1.08801972652009 0.291189196912942 3.73647009591974 0.000186621631435878 0.00152147778372623 30S ribosomal protein S7 RpsG II.A.1 - Ribosomal protein synthesis and modification Rv0684 fusA1 562.1 356.9 344.5 570.2 191.9 1710.61604305728 0.600282928601715 0.235430021897146 2.54972974034707 0.0107806454565648 0.0422868728761379 Probable elongation factor G FusA1 (EF-G) II.A.6 - Protein translation and modification Rv0685 tuf 912.9 653.5 498.2 333.5 154.3 1119.60935249584 -0.640774800850769 0.259174427579614 -2.4723689248004 0.0134220923740231 0.0504146884292574 Probable iron-regulated elongation factor TU Tuf (EF-TU) II.A.6 - Protein translation and modification Rv0686 - 181.4 90 96.5 190.4 52.1 189.485591456002 0.71029466762149 0.310026284257609 2.29107886553028 0.0219588527519453 0.0747867850455677 Probable membrane protein II.C.5 - Other membrane proteins Rv0687 - 33.4 18 12.9 53.5 24 51.9045359764977 1.69719704178389 0.461730107612689 3.67573397056348 0.000237166566923111 0.00188350668170776 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0688 - 37.2 26.3 7.5 44.7 10.5 57.3731026559182 0.972117500613381 0.499204813351412 1.94733198601806 0.0514949463342289 0.142719170513176 Putative ferredoxin reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0689c - 3.5 0 2.1 0 0 0.172807174947927 -0.25937561286276 4.45633197988856 -0.0582038353590628 0.953586265728918 NA Hypothetical protein VI - Unknowns Rv0690c - 232.9 155.3 111.8 101.5 17.9 220.274186935802 -0.831105791420941 0.332993854376487 -2.49585924934603 0.0125652448188285 0.0481667718055091 hypothetical protein VI - Unknowns Rv0691c - 371 238.3 98.4 289 54.4 220.218285735837 0.242500707475781 0.366083500218378 0.662419112937684 0.507702657939263 0.692179682225124 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv0691A - 278.5 230.7 218.8 789.8 120.4 122.119163930067 1.44500515963791 0.4000665748322 3.61191174304924 0.000303948017852626 0.00230531879921628 Mycofactocin precursor protein ? Rv0692 - 1135.8 1120.5 757.3 890 286.4 530.46562056224 -0.0775042392064369 0.288853268968625 -0.268316988355965 0.788455330696324 0.889681038969857 hypothetical protein VI - Unknowns Rv0693 pqqE 1171.5 888.4 635.2 295.9 114.9 1276.8678378867 -1.33699238571385 0.249033091801695 -5.36873383388944 7.92913376462279e-08 1.60485667395965e-06 Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0694 lldD1 532.9 332.7 231.1 77.9 3.2 438.630257028122 -2.80893482900754 0.861544531367313 -3.26034781342019 0.00111275665543184 0.00679548978196478 Possible L-lactate dehydrogenase (cytochrome) LldD1 I.B.6.a - aerobic Rv0695 - 189.1 159.6 80.8 18.6 19 121.865165063937 -2.08027539738054 0.475003013750627 -4.37949936560333 1.18952267927228e-05 0.000151013954479656 hypothetical protein V - Conserved hypotheticals Rv0696 - 106.1 103.7 44.5 16.8 9.8 135.422994272254 -1.90014377573306 0.422901268740529 -4.49311438906771 7.01890577945539e-06 9.52527366698506e-05 Probable membrane sugar transferase IV.H - Miscellaneous transferases Rv0697 - 48.5 58.1 27 3.3 0 63.8231364252154 -3.8834400297187 0.640974107324699 -6.05865351710917 1.37265705030988e-09 4.11822460509878e-08 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0698 - 53.9 39.3 24.1 11.6 1.8 24.4963515339128 -1.91491290182875 0.740463490087682 -2.58610036478908 0.00970686612196134 0.0386311458471765 hypothetical protein V - Conserved hypotheticals Rv0699 - 17.7 8.2 3.5 1.9 11.1 4.1712908432346 0.647221091247056 1.61696749988388 0.400268460122752 0.688958795703818 NA Hypothetical protein VI - Unknowns Rv0700 rpsJ 1044.5 490.7 617.9 2583.5 825.9 758.616330221162 1.99303684434682 0.264992081599211 7.5211184889713 5.43096008854669e-14 3.92580829257804e-12 30S ribosomal protein S10 RpsJ (transcription antitermination factor NusE) II.A.1 - Ribosomal protein synthesis and modification Rv0701 rplC 750.8 318.8 394.7 1299.6 380.5 864.402643936752 1.52310030399258 0.264989521891874 5.747775584176 9.04251440361806e-09 2.25553422659262e-07 50S ribosomal protein L3 RplC II.A.1 - Ribosomal protein synthesis and modification Rv0702 rplD 715.9 279.1 410.7 857.3 207.6 646.994571547724 0.851665348811878 0.300084064041843 2.83808922520165 0.00453844939777303 0.0211515628512001 50S ribosomal protein L4 RplD II.A.1 - Ribosomal protein synthesis and modification Rv0703 rplW 814.2 337.9 589.5 1494.3 678.3 551.069761377393 1.74156299610738 0.327581497350404 5.31642663030043 1.05824864541737e-07 2.09403167713313e-06 50S ribosomal protein L23 RplW II.A.1 - Ribosomal protein synthesis and modification Rv0704 rplB 741.4 364.7 455.5 640.1 244 829.041138687496 0.5577134020675 0.269466395283772 2.06969556066602 0.0384808627434101 0.115410004942556 50S ribosomal protein L2 RplB II.A.1 - Ribosomal protein synthesis and modification Rv0705 rpsS 965.7 588.5 615.1 493.6 190.6 302.620752778816 -0.314400915628251 0.292489954443823 -1.07491184176254 0.282414199750986 0.479305747732627 30S ribosomal protein S19 RpsS II.A.1 - Ribosomal protein synthesis and modification Rv0706 rplV 491.6 241 312.9 106.1 49.3 250.313449691337 -1.39024536034106 0.336018928502105 -4.13740192119073 3.51260514521086e-05 0.000375880586837972 50S ribosomal protein L22 RplV II.A.1 - Ribosomal protein synthesis and modification Rv0707 rpsC 584.4 331.6 327.7 122.4 46.4 399.938476298628 -1.52791805351733 0.281657353550374 -5.42474050209403 5.80387959964704e-08 1.22365128225892e-06 30S ribosomal protein S3 RpsC II.A.1 - Ribosomal protein synthesis and modification Rv0708 rplP 681.8 465.2 378.9 121.6 28.6 232.25262647331 -2.03699214824541 0.323896557240928 -6.28902068486701 3.19474904797752e-10 1.03814689247123e-08 50S ribosomal protein L16 RplP II.A.1 - Ribosomal protein synthesis and modification Rv0709 rpmC 1579.8 1240 1018.5 230.3 118.6 339.287193527122 -2.11066457068978 0.323824790144705 -6.51792152709063 7.12882673911569e-11 2.80558936777197e-09 50S ribosomal protein L29 RpmC II.A.1 - Ribosomal protein synthesis and modification Rv0710 rpsQ 1012.4 723 574 132.1 86.7 359.970231721694 -1.95357334381738 0.336360718304978 -5.80797113783684 6.3234413664044e-09 1.64688450880915e-07 30S ribosomal protein S17 RpsQ II.A.1 - Ribosomal protein synthesis and modification Rv0711 atsA 142.2 102 79.7 32.9 15 307.694565883 -1.39702800151705 0.300840772456762 -4.64374556051186 3.42148891610698e-06 4.94649540442895e-05 Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) I.C.5 - Sulphur metabolism Rv0712 - 60 34.7 34 22 7 49.754354035007 -0.832400462576316 0.476909701810653 -1.74540475778956 0.0809144380818254 0.200418838941137 hypothetical protein V - Conserved hypotheticals Rv0713 - 39.3 34.2 15.2 26.3 4.2 38.4050651096331 -0.256929274433472 0.556770631216022 -0.461463410654981 0.644466166595287 0.79647685134055 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv0714 rplN 487.6 203.1 188.7 935.9 348.1 356.82102140666 1.98033952696386 0.28515035409945 6.94489590664578 3.78739483507236e-12 1.88942993039807e-10 50S ribosomal protein L14 RplN II.A.1 - Ribosomal protein synthesis and modification Rv0715 rplX 551.5 358.9 245.3 1262 313.6 362.358768368832 1.73585099575379 0.274347908841533 6.32718872574472 2.4966792931006e-10 8.58566801569156e-09 50S ribosomal protein L24 RplX II.A.1 - Ribosomal protein synthesis and modification Rv0716 rplE 372.7 181.9 168.3 487.9 174.5 327.835648652741 1.27170596731422 0.273195872462859 4.65492379460128 3.24100555899536e-06 4.78318403748398e-05 50S ribosomal protein L5 RplE II.A.1 - Ribosomal protein synthesis and modification Rv0717 rpsN1 352.3 237.7 299.2 954.2 462.5 209.532360301525 2.07843774799532 0.348634689161487 5.9616492925424 2.49704629097264e-09 7.01947457351197e-08 30S ribosomal protein S14 RpsN1 II.A.1 - Ribosomal protein synthesis and modification Rv0718 rpsH 468.4 218.4 254.4 524 265.9 304.780911270969 1.22782195396649 0.310274965982409 3.95720599010913 7.58315348730637e-05 0.000708694713774121 30S ribosomal protein S8 RpsH II.A.1 - Ribosomal protein synthesis and modification Rv0719 rplF 504.2 307.1 290.8 254.7 76.7 281.905843497036 -0.418824337512428 0.285373098566309 -1.467637768299 0.142202643157342 0.300167915413174 50S ribosomal protein L6 RplF II.A.1 - Ribosomal protein synthesis and modification Rv0720 rplR 397.6 235.4 290.5 139.6 107.6 170.973375217935 -0.407818765362895 0.399146860187992 -1.02172610144251 0.306910553767297 0.503043582343252 50S ribosomal protein L18 RplR II.A.1 - Ribosomal protein synthesis and modification Rv0721 rpsE 530.4 356.5 276.5 150.8 29.6 298.514203637694 -1.43571751237818 0.311172770250354 -4.61389186214164 3.95198096824334e-06 5.64432120545077e-05 30S ribosomal protein S5 RpsE II.A.1 - Ribosomal protein synthesis and modification Rv0722 rpmD 362.6 247.7 212.6 86.2 36 65.3867266324981 -1.43258673803608 0.450364336247478 -3.18095067201073 0.00146792621936017 0.00852359781798973 50S ribosomal protein L30 RpmD II.A.1 - Ribosomal protein synthesis and modification Rv0723 rplO 1082.9 880 501.6 154.4 69 397.825134745119 -2.09227376512524 0.31116697709792 -6.72395825752046 1.76853116518151e-11 7.73350294700358e-10 50S ribosomal protein L15 RplO II.A.1 - Ribosomal protein synthesis and modification Rv0724 sppA 562 362.9 292.9 267.7 102.3 1100.03524984843 -0.330424897396717 0.237281363429415 -1.39254466773582 0.163757525284542 0.330312730386017 Possible protease IV SppA (endopeptidase IV) (signal peptide peptidase) II.B.3 - Proteins, peptides and glycopeptides Rv0724A - 36 19.6 10.8 12.3 0.7 7.64200535274424 -1.04545925774909 1.13607371830548 -0.920238925435623 0.357447917064603 0.557744723454988 hypothetical protein ? Rv0725c - 32.1 15.1 11.1 14.5 4.2 23.8292022237889 -0.273772619331356 0.635961198095159 -0.430486356952852 0.666841888920098 0.813625205151562 hypothetical protein V - Conserved hypotheticals Rv0726c - 45.3 19.7 21.2 29.7 16.2 59.72389364256 0.528502474050987 0.454643777193259 1.16245399269224 0.245051102427435 0.434202603700838 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0727c fucA 2.8 0 2.4 1.9 0 1.3975676047853 0.0418886191138441 2.34906807157675 0.0178320158622426 0.985772863852185 NA Possible L-fuculose phosphate aldolase FucA (L-fuculose-1-phosphate aldolase) I.A.1 - Carbon compounds Rv0728c serA2 3.4 0 0 3.7 0 1.88712063907609 1.3690003120028 2.27876307169907 0.600764655617337 0.547996748304541 NA Possible D-3-phosphoglycerate dehydrogenase SerA2 (phosphoglycerate dehydrogenase) (PGDH) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0729 xylB 8.5 7.1 3.3 6.1 1.5 11.673053502478 -0.067441112856561 0.879112866070245 -0.0767149651193618 0.93885029918208 0.973096145501906 Possible D-xylulose kinase XylB (xylulokinase) (xylulose kinase) I.A.1 - Carbon compounds Rv0730 - 188.3 138.1 75.2 83.6 27 132.216156914847 -0.508589100791829 0.35296380419305 -1.4409100727894 0.149610090013108 0.309712997560742 GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv0731c - 8.9 5.6 1.2 3.7 0.7 5.15615774847653 -0.63849638709508 1.39095761359866 -0.459033676405979 0.646209982884856 NA Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0732 secY 110.4 113.8 41.9 87.6 37 204.048547491279 0.328209390382312 0.367390223699078 0.893353631127491 0.37166782580249 0.57379582709341 Probable preprotein translocase SecY III.D - Protein and peptide secretion Rv0733 adk 180.4 104.2 91.8 88.9 21.6 93.7482347313556 -0.444872084678537 0.378142359230499 -1.17646720558847 0.239408229773204 0.426357455759955 Adenylate kinase Adk (ATP-AMP transphosphorylase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv0734 mapA 132.5 52.4 62.1 45.7 7.6 79.1436765141485 -0.904030065656364 0.44114618007979 -2.04927551564167 0.0404351814399278 0.119650302974289 Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) II.B.3 - Proteins, peptides and glycopeptides Rv0735 sigL 24.8 15.7 14.9 16.1 2.8 13.5665436170271 -0.284438923943857 0.817862558799006 -0.347783280801536 0.728002946769937 0.853457314122573 Probable alternative RNA polymerase sigma factor SigL II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv0736 rslA 11.2 4.3 8.4 6.6 0 7.22242648023305 -0.575655080082834 1.1520028342498 -0.499699360946197 0.617286782533521 0.775604747688446 Anti-sigma factor RslA VI - Unknowns Rv0737 - 8.9 8.6 2.2 9.5 0 4.34514692062169 0.310348327653468 1.43570720239498 0.216164080765047 0.828859851019419 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0738 - 35.3 20.4 13.9 60.7 0 22.6705156694884 0.943867987512042 0.762649494373845 1.237617010796 0.215858103922457 0.398213231298616 hypothetical protein II.C.5 - Other membrane proteins Rv0739 - 12.1 19.8 8.4 16.6 7.5 21.6614244130489 0.65552785125685 0.698439704346008 0.938560404252306 0.347956490246202 0.548736370637599 hypothetical protein V - Conserved hypotheticals Rv0740 - 71.7 39.1 45.3 71.3 22.1 50.6864048648386 0.552642007970023 0.463127319736137 1.19328310902688 0.232758515355263 0.417644711949514 hypothetical protein V - Conserved hypotheticals Rv0741 - 66.3 54.5 36.2 55.7 10.1 24.0193803084433 -0.0103066260305417 0.643661512679112 -0.0160124938768553 0.98722442430089 0.996155108273772 Probable transposase (fragment) IV.B.1.c - Others Rv0742 PE_PGRS8 16.5 8.7 4.7 7.4 1.2 5.57776922780256 -0.534385528659154 1.28177224713259 -0.416911451979561 0.67674317674863 NA PE-PGRS family protein PE_PGRS8 IV.C.1.b - PE_PGRS subfamily Rv0743c - 32.9 17 9.6 16.8 14.3 20.6185973396836 0.506997660174669 0.707522228366721 0.716581952972767 0.47363208333109 0.663395108793737 Hypothetical protein VI - Unknowns Rv0744c - 51.3 35.2 33.9 27.2 7.9 28.08035500794 -0.494584878681829 0.595691101565009 -0.830270718133018 0.406385739808032 0.604543591096198 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0745 - 0.3 0 0.1 0.4 0 0.0246867392782753 0.796308846248315 4.46498467717724 0.178345258454894 0.858451837397389 NA hypothetical protein V - Conserved hypotheticals Rv0746 PE_PGRS9 7.6 4.4 3.1 3.2 0 13.3196644007103 -0.931985686209537 0.894849705230505 -1.04149968510015 0.297643699273594 0.493333637261146 PE-PGRS family protein PE_PGRS9 IV.C.1.b - PE_PGRS subfamily Rv0747 PE_PGRS10 19.5 6.8 10.4 30.8 8.1 73.0921412172529 1.39227700943242 0.425848041091717 3.26942212969474 0.00107767395428277 0.00661546125835281 PE-PGRS family protein PE_PGRS10 IV.C.1.b - PE_PGRS subfamily Rv0748 vapB31 88.8 51.2 53.4 69.4 74 42.3574579095037 1.17920135412414 0.574411857161699 2.05288477147886 0.0400837543018739 0.119207941005237 Possible antitoxin VapB31 V - Conserved hypotheticals Rv0749 vapC31 25.1 8.1 12.2 19.8 15.4 15.1107618923861 1.02608248748103 0.79841909776933 1.28514271558354 0.198742417094407 0.376408170638811 Possible toxin VapC31 Contains PIN domain V - Conserved hypotheticals Rv0749A - 174.4 79.8 64.3 117.1 38.3 23.4480955591196 0.343165638111545 0.62989553870301 0.544797695849921 0.5858926635818 0.754483040505571 hypothetical protein ? Rv0750 - 198.3 74.3 76.2 314 53.9 66.3190457962139 1.34453148321947 0.451359208178218 2.97885023470836 0.00289332158210799 0.0148955596567246 hypothetical protein V - Conserved hypotheticals Rv0751c mmsB 72.4 43.5 32.9 73.1 10.1 72.1618993051049 0.380476380153178 0.441308694751834 0.86215473358651 0.388602375462551 0.589473583324055 Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh) I.A.2 - Amino acids and amines Rv0752c fadE9 47.4 24.1 26.6 52.2 25.5 89.5486314305417 1.08554229103158 0.390939207144603 2.77675472603608 0.00549045940781687 0.0249003933706624 Probable acyl-CoA dehydrogenase FadE9 I.A.3 - Fatty acids Rv0753c mmsA 52.9 43.8 32.5 42 16.7 113.155476836224 0.208291689183236 0.361457429751191 0.576255105135379 0.564442763392778 0.737460814436451 Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) I.A.2 - Amino acids and amines Rv0754 PE_PGRS11 6 1 5.5 6.8 2.2 14.6261578347827 0.829053186145411 0.851966328539875 0.973105577501246 0.330500832282576 0.530418644288575 PE-PGRS family protein PE_PGRS11 IV.C.1.b - PE_PGRS subfamily Rv0755c PPE12 69.7 61.6 64.8 96.5 61.5 322.680990179092 1.16001922627561 0.362199143132823 3.20271112803328 0.00136140466843631 0.00806370457458431 PPE family protein PPE12 IV.C.2 - PPE family Rv0755A - 256.5 157.2 105.3 446 50 67.3801669914632 1.10237755487009 0.473620595488043 2.32755409154904 0.0199357935808212 0.069228020454185 Putative transposase (fragment) ? Rv0756c - 139.6 66.8 51.5 74.9 20.3 90.1664772411435 -0.0791305975605608 0.38639556601138 -0.204791681171182 0.837734886735186 0.91350881138875 hypothetical protein VI - Unknowns Rv0757 phoP 200.1 148.2 120.7 210.3 85.6 234.74522377369 0.707143464716285 0.299481213580439 2.36122812600514 0.0182145220637181 0.0649052687622633 Possible two component system response transcriptional positive regulator PhoP I.J.2 - Two component systems Rv0758 phoR 62.2 29 26.2 74.7 21.1 123.080337028259 1.06106434298475 0.343761963631771 3.08662520941769 0.00202442667282267 0.0111690331388441 Possible two component system response sensor kinase membrane associated PhoR I.J.2 - Two component systems Rv0759c - 136.7 45.9 79.5 63.4 22.3 41.9106107827681 -0.279705988352223 0.532471327871658 -0.525297746021812 0.599376224048675 0.76284246697104 hypothetical protein V - Conserved hypotheticals Rv0760c - 100.6 58.9 48.6 56.4 17.6 42.5629260038308 -0.140632040993956 0.490699872820229 -0.286594818510332 0.774422582312043 0.881423631580758 hypothetical protein V - Conserved hypotheticals Rv0761c adhB 112.6 79.9 67.1 69.7 42.9 172.652601126551 0.257140167776908 0.352737018359266 0.728985488886251 0.466010538990423 0.658137691030334 Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0762c - 25.3 24.4 9.2 38.6 5.8 19.3964208351855 0.879759637899271 0.719884388159074 1.22208461854415 0.221675629147076 0.405223171830146 hypothetical protein VI - Unknowns Rv0763c - 17 17.5 13 29.9 13.9 7.73401605621095 1.25553175308695 1.0325062154643 1.2160040630093 0.223983374260547 0.408296983716801 Possible ferredoxin IV.F - Cytochrome P450 enzymes Rv0764c cyp51 28.8 24.1 10.2 62.1 15.3 77.4118830640487 1.62563302312156 0.418126554140564 3.88789711398013 0.000101116468489977 0.000915905035861288 Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) IV.F - Cytochrome P450 enzymes Rv0765c - 15 11.4 7 15.7 4.8 17.0268816229493 0.610838622892285 0.714710727522503 0.854665530220481 0.3927363383645 0.593207723022199 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0766c cyp123 9.7 15 1.5 21.6 11.8 34.0157032976194 1.96294712977878 0.674156643081458 2.91170776098337 0.00359458767610853 0.0175856761723431 Probable cytochrome P450 123 Cyp123 IV.F - Cytochrome P450 enzymes Rv0767c - 5.7 4 1.7 5.2 5.5 6.78871201705268 1.68575850266097 1.17425057968676 1.43560372191654 0.151115135062255 NA hypothetical protein VI - Unknowns Rv0768 aldA 8.8 5 4.6 10.8 2.7 17.7149448748737 0.856572149376023 0.70097380571349 1.22197454797067 0.221717252119374 0.405223171830146 Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0769 - 15.3 9 4 22.3 1.2 11.6480315068366 0.899591358814002 0.955394245591686 0.941591770062289 0.346401684900241 0.547015054800113 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0770 - 9.1 5.8 7 9.6 0.9 9.1778374887793 0.0212824250588501 1.02327490738052 0.0207983454938135 0.983406517559233 0.994639030609595 Probable dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0771 - 7.9 0.1 4.1 5.3 7.4 4.66956924757576 1.43693459698521 1.41738554153765 1.01379233445993 0.310681853808959 NA Possible 4-carboxymuconolactone decarboxylase (CMD) II.B.6 - Aromatic hydrocarbons Rv0772 purD 18.7 8.2 2.7 9.7 0 14.5359918838363 -0.289209059361831 0.914075417924248 -0.316395183253684 0.751702572536781 0.86982375430424 Probable phosphoribosylamine--glycine ligase PurD (GARS) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase) (5'-phosphoribosylglycinamide synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv0773c ggtA 35.5 26.8 10 11 2.6 43.0167781788818 -1.05015367824154 0.548709932323858 -1.91385942987035 0.0556381194264652 0.152211040786696 Probable bifunctional acylase GgtA: cephalosporin acylase (GL-7ACA acylase) + gamma-glutamyltranspeptidase (GGT) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv0774c - 56.4 30.8 21.2 22.6 4.3 40.8443382023448 -0.680217908309019 0.526795000641911 -1.29123835169308 0.196621040179338 0.373622169697005 Probable conserved exported protein V - Conserved hypotheticals Rv0775 - 100.7 70.5 42.8 93.5 21.4 75.5582558245493 0.418035444008551 0.406378022010161 1.02868615271251 0.303627178987947 0.499852027921654 hypothetical protein V - Conserved hypotheticals Rv0776c - 8.5 8.8 1.4 0.8 0 4.11019890349713 -2.77516139526124 1.61745765566107 -1.71575520728363 0.0862068556096036 NA hypothetical protein V - Conserved hypotheticals Rv0777 purB 117.5 65.6 67.6 80.8 25 191.182091458526 0.077699218942224 0.308270011349306 0.252049229836313 0.801003011928158 0.896375424790883 Probable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE) I.F.1 - Purine ribonucleotide biosynthesis Rv0778 cyp126 96.2 66 27.6 44.9 4.8 96.5130291809744 -0.668623718670862 0.460078782083069 -1.45328092646128 0.146145770839056 0.305217169995245 Possible cytochrome P450 126 Cyp126 IV.F - Cytochrome P450 enzymes Rv0779c - 7.8 2.8 3.5 3.9 0 3.1283440633473 -0.352292426645739 1.64470718972679 -0.214197657094367 0.830392923053654 NA Possible conserved transmembrane protein V - Conserved hypotheticals Rv0780 purC 34.8 18.2 13.3 8 4.6 23.834834766198 -1.07330977423774 0.662412755081528 -1.62030360376384 0.105167075167842 0.241884272886037 Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC (SAICAR synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv0781 ptrBa 86.9 61.1 40.2 74.2 13.6 70.3575530024546 0.177081139610592 0.426032754544505 0.415651467455641 0.677665059624754 0.820589432842296 Probable protease II PtrBa [first part] (oligopeptidase B) II.B.3 - Proteins, peptides and glycopeptides Rv0782 ptrBb 23.7 19.2 12.4 16.9 1.4 40.9324796290588 -0.340178292399484 0.556069790114035 -0.611754672609929 0.54070008334447 0.719714278544199 Probable protease II PtrBb [second part] (oligopeptidase B) II.B.3 - Proteins, peptides and glycopeptides Rv0783c emrB 48.6 27.6 18.8 26.2 6.1 71.685493822664 -0.225246816067848 0.417673477653005 -0.53928924894527 0.589687285981553 0.757314128697121 Possible multidrug resistance integral membrane efflux protein EmrB III.A.6 - Efflux proteins Rv0784 - 24 10 10.1 17.5 8.6 19.2994380728507 0.71596695619796 0.693224498410705 1.03280677160053 0.301694334154649 0.498174242367584 hypothetical protein V - Conserved hypotheticals Rv0785 - 18.3 10.1 6.1 8.5 4.6 30.0731198777271 -0.000305634989815945 0.582577495750319 -0.000524625465359434 0.999581409460187 0.999585202738999 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0786c - 116.9 65 63.6 33.3 15.2 40.7016363416114 -0.98369168351905 0.526017182836063 -1.87007519072932 0.0614733771103105 0.162216617313321 hypothetical protein V - Conserved hypotheticals Rv0787 - 8.7 3.7 6.1 2 1.1 6.08726865447642 -1.89801276899102 1.29598329897389 -1.46453489832299 0.143047855003111 NA hypothetical protein VI - Unknowns Rv0787A - 193.7 94.1 120.9 110.8 45.3 51.6586115651337 -0.04461588003934 0.473530329788254 -0.0942196882283983 0.924934645399768 0.964764669704692 hypothetical protein ? Rv0788 purQ 121.1 51.8 63 74.9 27.1 85.8942392284894 0.145095780938795 0.394199431092855 0.368077093710005 0.712815750333084 0.844695010933351 Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I) I.F.1 - Purine ribonucleotide biosynthesis Rv0789c - 15.2 14.8 5 4.7 0 7.03346654561824 -1.45056138725644 1.21395330624059 -1.19490706915951 0.232123340626276 NA Hypothetical protein VI - Unknowns Rv0790c - 15.3 11.8 5.4 9.4 0 9.42003700982638 -0.509234071491568 1.02334981137446 -0.497614858410554 0.618755528994814 0.776623700814895 Hypothetical protein VI - Unknowns Rv0791c - 17 15.2 7.2 14.8 1.9 19.2519270913145 -0.00853458535002587 0.734628147042976 -0.0116175583312173 0.990730738082198 0.996155108273772 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0792c - 27.9 19.8 8.7 20.8 0 19.1604714473239 -0.191474922195212 0.796278522958098 -0.24046224615465 0.809971927914224 0.900180115344522 Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv0793 - 1.9 0 0 0 0 0.123433696391377 -0.0198230044504359 4.45780257757907 -0.00444681075607464 0.996451970046118 NA Possible monooxygenase V - Conserved hypotheticals Rv0794c - 21.4 10.9 12.4 12.5 1.3 28.364469181429 -0.485527440825454 0.642780014487058 -0.75535553359248 0.450035686053188 0.64349198451521 Probable oxidoreductase I.B.3 - TCA cycle Rv0795 - 11.9 12.4 4.6 5 0.1 3.02490067675801 -0.992950332338063 1.65494408898214 -0.599990258854467 0.548512727497823 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv0796 - 6.4 6.5 4.2 2 4 9.88909514503939 -0.141972382637008 1.03850026198338 -0.136709048455955 0.891260777055501 0.944103829229912 Putative transposase for insertion sequence element IS6110 IV.B.1.a - IS6110 Rv0797 - 5.2 1.3 3.9 5.1 0 5.21410147969997 0.1771890259723 1.32699741740966 0.13352627793216 0.893777183558379 NA Putative transposase for insertion sequence element IS1547 IV.B.1.c - Others Rv0798c cfp29 75.7 32.6 42.2 31.5 5.7 49.8895514175984 -0.780288674472261 0.510591116811256 -1.5282065213851 0.126461270159044 0.275307817396026 29 KDa antigen CFP29 IV.E - Bacteriocin-like proteins Rv0799c - 70.7 79.2 44.2 36.2 11.7 89.6396964628954 -0.709506867380273 0.423021758084089 -1.67723492662341 0.0934965517601545 0.22300659012422 hypothetical protein V - Conserved hypotheticals Rv0800 pepC 21.2 15.5 13.2 4.8 0 22.649025532634 -2.00272881763916 0.762681220317847 -2.62590550846988 0.00864188038604936 0.035528959966192 Probable aminopeptidase PepC II.B.3 - Proteins, peptides and glycopeptides Rv0801 - 42.9 17.1 6.8 20.6 0 8.42009019173138 -0.275542997675827 1.11198231388416 -0.247794406651445 0.804293482840646 0.897686131592986 hypothetical protein VI - Unknowns Rv0802c - 13 10 4.4 9.4 3 8.65011829505582 0.123801447089551 0.991257612109346 0.124893312875658 0.900608012471854 0.950805836117826 Possible succinyltransferase in the GCN5-related N-acetyltransferase family IV.D - Antibiotic production and resistance Rv0803 purL 46.6 21.5 22.9 18.1 3 84.0148992174588 -0.844717999004323 0.429569647349587 -1.96642850400667 0.0492491335320118 0.138554750572189 Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II) I.F.1 - Purine ribonucleotide biosynthesis Rv0804 - 36.1 17.1 14.9 10.3 1.5 14.8780373076279 -1.34186587484779 0.870193209269023 -1.54203211488513 0.123065789711481 0.269906518364127 hypothetical protein V - Conserved hypotheticals Rv0805 - 325.5 136.5 142.3 434.7 118.5 442.884715937643 1.20196480220549 0.275645565027404 4.36054468021641 1.29739085826805e-05 0.000163535886832221 Class III cyclic nucleotide phosphodiesterase (cNMP PDE) V - Conserved hypotheticals Rv0806c cpsY 17.4 16.5 4.5 19.4 8.1 43.4701854543883 0.985035461278477 0.534512560024567 1.84286681913181 0.0653484579151199 0.169446733481226 Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0807 - 41.9 14.5 5.2 11.8 5.1 9.06905362303964 -0.584491745649017 1.04219000106463 -0.560830314100058 0.57491321915818 0.744821734549478 hypothetical protein V - Conserved hypotheticals Rv0808 purF 411.6 282.4 222 200.3 46.7 649.882395030829 -0.646033248108794 0.263225144799824 -2.45429914607925 0.0141159497627467 0.052626937619532 Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) I.F.1 - Purine ribonucleotide biosynthesis Rv0809 purM 226.9 136.5 100.2 169.3 40.6 268.734910476474 0.151796772527074 0.29005834887995 0.523331850688774 0.600743339907839 0.763754495213739 Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) I.F.1 - Purine ribonucleotide biosynthesis Rv0810c - 725.8 418.6 266 1703 578.6 301.694927073567 2.09450683989896 0.283528423911268 7.38729052630873 1.49850941563045e-13 9.47807205386257e-12 hypothetical protein VI - Unknowns Rv0811c - 135.1 98.5 56.2 98.8 29 172.144587277231 0.167457187220825 0.32251878076394 0.519216855601942 0.603609526114057 0.76520577719971 hypothetical protein V - Conserved hypotheticals Rv0812 - 44.1 35.8 13.3 11.7 6.1 33.3186897724169 -1.05531276430718 0.602505592239923 -1.75154019796542 0.0798529033779054 0.198622881857121 Probable amino acid aminotransferase I.G.2 - Folic acid Rv0813c - 133.5 44 63 104.6 16.2 85.9042090849491 0.247736981653439 0.439245838889542 0.564005301176542 0.572750524379238 0.743263052300572 hypothetical protein V - Conserved hypotheticals Rv0814c sseC2 277.9 125.7 126.9 277.2 79.8 103.70983738959 0.772433452225589 0.362447226839537 2.13116115954602 0.0330758675984867 0.101856570706718 Conserved protein SseC2 I.C.5 - Sulphur metabolism Rv0815c cysA2 160.9 71.8 89.9 222.2 107.8 246.465913124068 1.50169200396075 0.321860616469585 4.665659378996 3.07628940275268e-06 4.6209545386765e-05 Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.D.3 - Serine family Rv0816c thiX 23 5.9 0.5 5.5 0 3.59063220892004 -0.857630001285994 1.74170466569812 -0.492408396312262 0.622430664868112 NA Probable thioredoxin ThiX I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv0817c - 19.6 6.4 7.6 6.3 0 9.59990970688989 -1.07824261977631 1.03666188148232 -1.04011022208566 0.298288695076285 0.493940419803741 Probable conserved exported protein II.C.5 - Other membrane proteins Rv0818 - 295 169.9 126 159.9 62.4 233.540879746842 -0.00767828597728489 0.293672739272711 -0.0261457226036723 0.97914110814951 0.992876554556417 Transcriptional regulatory protein I.J.2 - Two component systems Rv0819 mshD 147.2 91.1 92.3 44.1 9.5 123.792680124183 -1.36634444684463 0.379253180609082 -3.6027237652965 0.00031490011933206 0.00235808926569589 GCN5-related N-acetyltransferase, MshD V - Conserved hypotheticals Rv0820 phoT 155.2 96.8 78.8 58.6 29 120.657518948103 -0.510699549753798 0.362540850374514 -1.40866760042691 0.158933479543669 0.324652215937749 Probable phosphate-transport ATP-binding protein ABC transporter PhoT III.A.4 - Anions Rv0821c phoY2 1405.5 970.1 727.3 820.2 319.1 1035.06930835863 -0.0489253302844759 0.24162311099394 -0.202486136707771 0.839536695249585 0.91350881138875 Probable phosphate-transport system transcriptional regulatory protein PhoY2 III.A.4 - Anions Rv0822c - 663.1 429.9 371.1 129 33.4 1120.82915878692 -1.89643700718878 0.249537444607859 -7.59980935994989 2.96567310081514e-14 2.23498172831643e-12 hypothetical protein V - Conserved hypotheticals Rv0823c - 1786.2 1093.6 934.2 1304.6 429.1 2481.70499577563 0.210474686571205 0.219955457349869 0.956896860423959 0.338619316036011 0.539536490058278 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0824c desA1 5416.9 4511.9 2805.4 4605.8 2365.9 8383.36333955601 0.632268005206946 0.272117019004809 2.32351510948962 0.0201514969187755 0.0698401194582221 Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) I.H.2 - Modification of fatty and mycolic acids Rv0825c - 19.7 19.7 9.2 45.4 24.3 36.7597884464922 2.01081626888431 0.551526560107619 3.64591012351597 0.000266447095986516 0.00208795489819522 hypothetical protein V - Conserved hypotheticals Rv0826 - 9.3 6.7 1.8 5.8 0 7.05384497397884 -0.165969455284974 1.1859536229977 -0.139945991197748 0.888702663092196 NA hypothetical protein V - Conserved hypotheticals Rv0827c kmtR 127.6 54.5 76.4 92.9 33.9 58.4492046077622 0.32099775830621 0.451078363743497 0.711623044036631 0.476698233322207 0.665536122359976 Metal sensor transcriptional regulator KmtR (ArsR-SmtB family) I.J.1 - Repressors/activators Rv0828c - 8.1 4.5 0.9 5.4 4.7 3.17582101158309 1.13365640196878 1.66466368621307 0.681012273745049 0.495863724189523 NA Possible deaminase V - Conserved hypotheticals Rv0829 - 11.5 0 0 3.6 6.8 2.34995079112934 1.08223925724096 2.04838371702313 0.528338146923835 0.597264659474387 NA Possible transposase (fragment) IV.B.1.c - Others Rv0830 - 66.7 29.3 17.3 29.5 3.4 41.1384882741667 -0.478235841320764 0.575900919691888 -0.830413400931231 0.406305091433378 0.604543591096198 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0831c - 491.5 403 280.3 218.1 204.4 551.382126172691 0.213421141216929 0.371735378333791 0.574121145459801 0.565885825165161 0.738415274699507 hypothetical protein V - Conserved hypotheticals Rv0832 PE_PGRS12 82.2 46 19.4 41.8 0 23.473013505224 -0.539983601237907 0.757140299944835 -0.713188297171938 0.475729246981978 0.664707294994149 PE-PGRS family protein PE_PGRS12 IV.C.1.b - PE_PGRS subfamily Rv0833 PE_PGRS13 17.4 6.3 5.8 2 0 20.548851651039 -2.37558500519945 0.819614635184284 -2.89841701602281 0.00375051544266918 0.0181050448939553 PE-PGRS family protein PE_PGRS13 IV.C.1.b - PE_PGRS subfamily Rv0834c PE_PGRS14 36.3 9.8 17.6 72.5 11.7 151.327685448369 1.59967426660572 0.406587701322607 3.93438921394344 8.34085295310675e-05 0.000769356801039169 PE-PGRS family protein PE_PGRS14 IV.C.1.b - PE_PGRS subfamily Rv0835 lpqQ 45 42.2 26.1 44.4 9.6 39.9089858255996 0.214474176392104 0.521369107768822 0.411367250564456 0.680803264051858 0.821853087261539 Possible lipoprotein LpqQ II.C.1 - Lipoproteins(lppA-lpr0) Rv0836c - 2.8 0.8 6.4 1.2 0 2.37767692377876 -1.48262099100983 2.00127684774968 -0.740837527140209 0.458791958319617 NA Hypothetical protein VI - Unknowns Rv0837c - 5.2 6.6 1.9 0.7 3.7 8.37659695905064 -0.0577564932424147 1.20772918986201 -0.0478223874418517 0.961857794368181 0.984368768463478 Hypothetical protein VI - Unknowns Rv0838 lpqR 33.9 15.8 13.6 19.6 4.2 22.1179412060274 -0.13316133595241 0.662580507982331 -0.200973820310394 0.840719044769279 0.91350881138875 Probable conserved lipoprotein LpqR II.C.1 - Lipoproteins(lppA-lpr0) Rv0839 - 247.7 105.6 120.5 67.1 24.4 157.775688507026 -1.02221753024065 0.34459464833801 -2.96643472314744 0.00301274307915566 0.0153541524983732 hypothetical protein V - Conserved hypotheticals Rv0840c pip 36.6 30.1 22.1 37.3 10.1 44.7218239619853 0.391790709156596 0.486082460379437 0.806016964386584 0.420233067529661 0.61532266440267 Probable proline iminopeptidase Pip (prolyl aminopeptidase) (pap) II.B.3 - Proteins, peptides and glycopeptides Rv0841 - 6.9 7.1 4.4 8.6 0 1.69079814564078 0.560570382531033 2.0768567418138 0.269912879037321 0.787227278754856 NA Probable conserved transmembrane protein ? Rv0842 - 8.8 7.5 5.8 7.3 1.5 13.5141598079867 -0.122825490993866 0.82196788676969 -0.149428576189961 0.881215464321144 0.939574104342411 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0843 - 11.5 9.5 3.2 4.6 3.9 12.7741276887127 -0.0982846607729018 0.875771670643269 -0.11222635313233 0.910643934379723 0.956928258280116 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0844c narL 136 105.2 62.9 65.2 26.5 94.7209176598154 -0.368161798898757 0.384583189680108 -0.957300809754554 0.338415446755327 0.53947231466201 Possible nitrate/nitrite response transcriptional regulatory protein NarL I.J.2 - Two component systems Rv0845 - 14.9 8.9 3.4 10.3 3.1 17.9695784497805 0.400782038891907 0.728997105505731 0.549771783543462 0.582475914262316 0.752143524723705 Possible two component sensor kinase I.J.2 - Two component systems Rv0846c - 5.7 2.5 2.7 4.6 2.6 10.9443225960112 0.822915569651048 0.887967567865243 0.926740569623972 0.354061248112823 0.554169218212823 Probable oxidase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0847 lpqS 38.3 14.9 7.8 8 12.2 12.4497679527996 0.0589354798534302 0.96128756375543 0.0613088966044551 0.951113205666827 0.97846150870517 Probable lipoprotein LpqS II.C.1 - Lipoproteins(lppA-lpr0) Rv0848 cysK2 21.2 12.9 2.9 13.8 0 17.142779838896 -0.159182499194723 0.87231052563761 -0.182483753796699 0.855203102891498 0.921548339045235 Possible cysteine synthase a CysK2 (O-acetylserine sulfhydrylase) (O-acetylserine (thiol)-lyase) (CSASE) I.D.3 - Serine family Rv0849 - 2.5 1.2 0 0.3 0 1.15072876974307 -1.44633784690438 2.59918327710497 -0.556458584373222 0.5778973992664 NA Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv0850 - 4 8.5 0 0.7 0 1.0197125663517 -2.15583554573844 2.92798282451873 -0.736286950758597 0.461556085911818 NA Putative transposase (fragment) IV.B.1.c - Others Rv0851c - 10.5 5.7 3.9 8.5 0 7.17829497377764 0.0354555022354237 1.12637802354271 0.0314774449557425 0.974888779547925 NA Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0852 fadD16 7.4 7.2 6.4 14 2.4 10.7878273394048 0.828092957469073 0.90831581910671 0.911679550273018 0.36193743209819 0.563013783263851 Possible fatty-acid-CoA ligase FadD16 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv0853c pdc 21.4 7.9 5.4 17 4.7 34.0172667485584 0.699258364167574 0.566092140901593 1.23523771775721 0.216742045647464 0.399427848950738 Probable pyruvate or indole-3-pyruvate decarboxylase Pdc I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0854 - 63.5 38.2 47.4 57.4 25.8 41.756062953691 0.482987513338262 0.508630811222493 0.949583671853074 0.342323838322788 0.544599788735891 hypothetical protein V - Conserved hypotheticals Rv0855 far 21.6 8.7 9.8 17.2 1.9 20.6808410275072 0.109264007810789 0.714403081281864 0.152944480047224 0.878442058520069 0.937746163736614 Probable fatty-acid-CoA racemase Far I.A.3 - Fatty acids Rv0856 - 196.6 152.3 154.8 182 82.3 129.011364255383 0.429570843852626 0.368733641215203 1.16498956384052 0.244023217245211 0.432597715456725 hypothetical protein V - Conserved hypotheticals Rv0857 - 196.3 59.4 89.7 161.8 32.2 91.3567265419058 0.427200181595416 0.426537310967745 1.00155407419381 0.316559011340188 0.514571830273954 hypothetical protein V - Conserved hypotheticals Rv0858c dapC 16.3 10.1 14.5 3.2 0 17.0741115179317 -2.32001125046104 0.883124952403182 -2.62704755895275 0.00861292952136596 0.0354732515868352 Probable N-succinyldiaminopimelate aminotransferase DapC (DAP-at) IV.H - Miscellaneous transferases Rv0859 fadA 197.2 140.6 141.1 174.7 76.3 363.739150710239 0.448905650497394 0.296886378024554 1.51204529316689 0.130522340537014 0.28172463752718 Possible acyl-CoA thiolase FadA I.A.3 - Fatty acids Rv0860 fadB 257.9 168.3 169.8 241.5 96.2 825.240775140979 0.556486150313869 0.260764526186539 2.13405618644533 0.0328381817845815 0.101672062833031 Probable fatty oxidation protein FadB I.A.3 - Fatty acids Rv0861c ercc3 123.5 94.2 55.7 45.8 12.3 185.880858755345 -0.934173754282718 0.330168167224734 -2.82938770910297 0.00466371628130732 0.0216215746968463 DNA helicase Ercc3 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0862c - 40.4 25.2 17.6 9.9 3.6 74.9585636989161 -1.25868044532308 0.420092960654312 -2.9961950406468 0.00273371521094705 0.0142394401134918 hypothetical protein V - Conserved hypotheticals Rv0863 - 703.1 452.2 272 437.2 133.4 206.02624214388 0.0322516119415537 0.307358294931327 0.104931646464136 0.916430047331255 0.959264137345829 hypothetical protein V - Conserved hypotheticals Rv0864 moaC2 683 489.2 368.8 432.6 160.6 409.974143853258 -0.012457580170097 0.266660019573572 -0.0467170901360411 0.962738709258285 0.984610856411041 Probable molybdenum cofactor biosynthesis protein C 2 MoaC2 I.G.4 - Molybdopterin Rv0865 mog 272 153.9 148.7 180.5 45.8 140.436990357727 -0.0540711578454335 0.336444831190711 -0.160713296304985 0.87231921663315 0.934872818552078 Probable molybdopterin biosynthesis Mog protein I.G.4 - Molybdopterin Rv0866 moaE2 177 97.2 99.3 69.8 9.3 64.0982895535149 -0.97961184559515 0.473023919539261 -2.07095625639676 0.0383628841500247 0.115251344918904 Probable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) I.G.4 - Molybdopterin Rv0867c rpfA 75.1 36.4 31.3 24.7 10 76.2662964155731 -0.664733086863792 0.411007887755322 -1.61732440341757 0.105808274295896 0.242728567069989 Possible resuscitation-promoting factor RpfA II.C.5 - Other membrane proteins Rv0868c moaD2 385.8 350.5 224.7 244.9 161.2 159.171961885988 0.25723935739766 0.379420755960051 0.677979138876485 0.497784920227104 0.684221070039329 Probable molybdenum cofactor biosynthesis protein D 2 MoaD2 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) I.G.4 - Molybdopterin Rv0869c moaA2 229 134.7 98.8 105 22.3 219.45010282976 -0.56905112060867 0.314488496875365 -1.8094497136224 0.0703811657674564 0.179087707721502 Probable molybdenum cofactor biosynthesis protein A2 MoaA2 I.G.4 - Molybdopterin Rv0870c - 324.2 207.7 185.5 297.5 66 156.238469298547 0.267702209471812 0.332907319324219 0.804134345905133 0.421319390755816 0.61614916682787 Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv0871 cspB 215.1 133.1 95.7 132.8 37.6 91.280323909511 -0.0276011046640798 0.373755061001002 -0.0738481094815349 0.941131245673191 0.973691654363404 Probable cold shock-like protein B CspB III.E - Adaptations and atypical conditions Rv0872c PE_PGRS15 116.5 56.2 85.1 130.7 65.4 363.626868693088 1.04488439340909 0.331056421611212 3.15621243147548 0.00159832406651587 0.0091310707154826 PE-PGRS family protein PE_PGRS15 IV.C.1.b - PE_PGRS subfamily Rv0873 fadE10 169.9 108.2 91.5 182.5 56.2 470.764129839577 0.689939532407853 0.253008366526705 2.72694354688477 0.0063923974609071 0.0282670060006654 Probable acyl-CoA dehydrogenase FadE10 I.A.3 - Fatty acids Rv0874c - 21.8 9.3 13.9 21.8 3.2 29.0407223779849 0.382983491716267 0.606548091105081 0.631414882566858 0.527769287502621 0.708044721646746 hypothetical protein V - Conserved hypotheticals Rv0875c - 113.8 56 59.4 70.4 19.1 55.6527102012448 -0.0735117500283404 0.451532418472904 -0.162805032420395 0.870671945838524 0.933389840242146 Possible conserved exported protein II.C.5 - Other membrane proteins Rv0876c - 105.1 57.8 40.7 68.1 18.3 172.999166554795 0.104162542557672 0.31791237897899 0.327645443981142 0.743179757552295 0.86306318073778 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv0877 - 192.4 138.1 107.8 174.3 48.7 199.282039061116 0.319973056911004 0.304120227624285 1.05212684934033 0.292741355179498 0.488638020756731 hypothetical protein V - Conserved hypotheticals Rv0878c PPE13 10.8 13.9 16.9 4.1 5.6 29.1493809732975 -0.785405097849296 0.743971643136627 -1.05569224995994 0.291108839054023 0.4868307402877 PPE family protein PPE13 IV.C.2 - PPE family Rv0879c - 84.1 67.6 44.2 16.9 14.3 22.6872166355241 -1.41825596259261 0.714046110102738 -1.98622461844733 0.0470083884548666 0.134272255395661 Possible conserved transmembrane protein VI - Unknowns Rv0880 - 13.5 3.9 8.7 15.8 4.6 6.64581992841397 0.895768448520815 1.12690329223703 0.79489380738485 0.426675276791738 NA Possible transcriptional regulatory protein (possibly MarR-family) V - Conserved hypotheticals Rv0881 - 7.5 0.3 3.1 6.8 0 4.60819563081186 0.542242608202146 1.47389170584838 0.367898541019353 0.712948888158467 NA Possible rRNA methyltransferase (rRNA methylase) IV.H - Miscellaneous transferases Rv0882 - 14.4 22.2 12.4 9 6.1 6.69376042726406 -0.571789449577392 1.16917125474504 -0.489055343480952 0.624802515793308 NA Probable transmembrane protein II.C.5 - Other membrane proteins Rv0883c - 80.9 59.7 37.2 40.9 21.3 70.0257493547129 -0.136383356091373 0.427979685052261 -0.318667826662659 0.749978414258343 0.868396058614923 hypothetical protein V - Conserved hypotheticals Rv0884c serC 117.7 98.7 69.2 45.8 17 142.180793287103 -0.855347622976958 0.350250614152396 -2.44210170779256 0.0146020321691492 0.0542102863007287 Possible phosphoserine aminotransferase SerC (PSAT) I.D.3 - Serine family Rv0885 - 63.7 33.4 26.7 163.3 47.6 149.670432282892 2.11302945185363 0.324661083216293 6.50841619488438 7.59472590168116e-11 2.89252894018867e-09 hypothetical protein II.C.5 - Other membrane proteins Rv0886 fprB 21.5 9 8 40.5 10.8 63.4678276775726 1.73280656803425 0.433483437156585 3.99739971474002 6.40421085478784e-05 0.000616405294773329 Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) I.B.6.c - Electron transport Rv0887c - 4.1 3.8 0 15.9 0 3.24627177697252 2.45147106364874 1.70726225571132 1.4359077262136 0.151028599691725 NA hypothetical protein VI - Unknowns Rv0888 - 16.4 13 6.1 12.7 7.5 34.0938087632267 0.632828336857795 0.561428752359352 1.12717479145554 0.259668586423512 0.453747475634968 Probable exported protein II.C.5 - Other membrane proteins Rv0889c citA 200.2 108.8 116.3 110.4 31.1 231.302167676663 -0.289961062116889 0.302562362324917 -0.958351395357976 0.337885595547375 0.53947231466201 Probable citrate synthase II CitA I.B.3 - TCA cycle Rv0890c - 32.3 21.9 13.5 3.7 0.7 59.78939871105 -2.63517616853091 0.524082010973503 -5.02817519654217 4.95169372990759e-07 8.63985181839049e-06 Probable transcriptional regulatory protein (probably LuxR-family) I.J.1 - Repressors/activators Rv0891c - 29.4 25.3 11.9 5.7 0 19.2011220075795 -2.15334218943658 0.830632948028223 -2.5924112383794 0.00953057712058536 0.0381438465097326 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv0892 - 20.6 19.7 7.9 8.4 1.3 27.8082516592303 -1.07122974598837 0.663947757070089 -1.61342475304919 0.106652258966903 0.243560477924416 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0893c - 31 16.5 9.8 8.1 4 23.055076881214 -0.885072505175834 0.667561000733835 -1.3258301551512 0.184895962153071 0.358313944547312 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv0894 - 3.3 2.3 0.5 0.9 1.7 3.22154292181139 0.108376166355513 1.71109933407989 0.0633371565267955 0.949498028516697 NA Possible transcriptional regulatory protein (possibly LuxR-family) I.J.1 - Repressors/activators Rv0895 - 4.3 2.3 2.8 1.2 0 4.85375429684816 -1.54841498369543 1.38600072428637 -1.11718194410951 0.263916539140642 NA Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv0896 gltA2 554.8 434.7 297.9 295 133.8 853.099092651164 -0.154637621515215 0.266861868793407 -0.579466906285246 0.562274170380636 0.73610156192777 Probable citrate synthase I GltA2 I.B.3 - TCA cycle Rv0897c - 75.1 54.6 38.1 22.6 9.7 114.171052241485 -1.01750626046367 0.369685894169472 -2.7523534884921 0.0059168615348107 0.0264281507645643 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0898c - 450.3 320.4 279 181 78.7 127.305031973697 -0.675634917296545 0.357163298488563 -1.89166949727389 0.0585350298737701 0.157569975405751 hypothetical protein VI - Unknowns Rv0899 ompA 42.8 29.3 28.8 41.4 21.9 68.9504054541171 0.747999208254604 0.431664615546507 1.73282493240175 0.0831267899542817 0.204326918818921 Outer membrane protein A OmpA II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0900 - 80.6 34.8 35.9 75.6 2.6 10.8285593195964 0.226080094369065 0.958401421326042 0.235892903890168 0.813515774764691 0.901587257264248 Possible membrane protein VI - Unknowns Rv0901 - 95.6 45.9 40.5 45.1 20.8 48.8783234194812 -0.0712871414071328 0.47660166023774 -0.149573841961803 0.881100847071353 0.939574104342411 Possible conserved exported or membrane protein V - Conserved hypotheticals Rv0902c prrB 95.8 52.7 55.2 51.1 26.1 147.487000932063 0.00787926684373221 0.348947891226903 0.0225800672301777 0.981985243820395 0.994053081912501 Two component sensor histidine kinase PrrB I.J.2 - Two component systems Rv0903c prrA 145.3 86.7 57.1 109.2 20.3 105.002851429093 0.133115356328962 0.380270382595587 0.350054493911319 0.726297801410411 0.85240119701646 Two component response transcriptional regulatory protein PrrA I.J.2 - Two component systems Rv0904c accD3 6.3 2.7 1.4 3.3 0 5.71818059682926 -0.217834436029422 1.26782160616599 -0.171817892178201 0.863580698784578 NA Putative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain) I.H.1 - Synthesis of fatty and mycolic acids Rv0905 echA6 194.4 121.8 78.1 56.9 16.9 115.573043045537 -1.06522340690899 0.365948934933578 -2.91085259505493 0.00360444020592279 0.0176095547715566 Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0906 - 95.1 38.9 34.4 22.8 8.2 73.5273810609485 -1.07652003817049 0.432905403984361 -2.48673273251489 0.0128922213023048 0.0488910576582052 hypothetical protein II.C.5 - Other membrane proteins Rv0907 - 83.6 31.9 53.2 23.4 10.7 116.172900248782 -0.957750614050468 0.410201865289123 -2.33482754490991 0.0195524316317523 0.0685011996435873 hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv0908 ctpE 88.9 54.5 44 12.9 1.6 154.444533510975 -2.37326836084966 0.395617925038542 -5.99888986480692 1.98671041748289e-09 5.7210799176621e-08 Probable metal cation transporter ATPase P-type CtpE III.A.2 - Cations Rv0909 - 497 293.2 280.3 424.8 146.7 115.86029046513 0.433648352854599 0.345633618116421 1.25464749412348 0.209606754124239 0.390056125636197 hypothetical protein VI - Unknowns Rv0910 - 294 220.4 113.3 203.8 48.7 136.701403450134 -0.0113979982659895 0.358150919043103 -0.0318245679682809 0.974611954151576 0.99017882337715 hypothetical protein V - Conserved hypotheticals Rv0911 - 59.9 57.7 23.1 37 12.5 54.160823726747 -0.134427260817223 0.484773484869705 -0.277299120131032 0.781550435116983 0.885336132396263 hypothetical protein V - Conserved hypotheticals Rv0912 - 28.5 17.3 7.1 6.6 0 7.8472083336134 -1.52119474271188 1.15199902124489 -1.32048266939327 0.186673918517484 0.360916495299634 Probable conserved transmembrane protein V - Conserved hypotheticals Rv0913c - 81.8 62.6 55 50.5 16.6 151.427586747392 -0.268881729791557 0.337712664117306 -0.796184918011127 0.425924562411169 0.620833251053647 Possible dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0914c - 88 73.2 45.1 24.5 15.9 111.92713718353 -0.955859367243439 0.40721259131955 -2.34732271943269 0.0189088690859758 0.0667083807794088 Possible lipid carrier protein or keto acyl-CoA thiolase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv0915c PPE14 7.9 2.7 5.1 12.5 0 11.6142961097455 0.759590052969 0.956761503092769 0.793917868260372 0.427243246750113 0.6222432483507 PPE family protein PPE14 IV.C.2 - PPE family Rv0916c PE7 14.9 29.6 10.2 25.9 0 7.75441403060777 0.168080796677261 1.13763463413386 0.147745850586933 0.88254334515504 0.94007980290874 PE family protein PE7 IV.C.1.a - PE subfamily Rv0917 betP 17.6 11.7 6.8 20 1.1 33.0787193743098 0.368667110897648 0.636362819090915 0.57933477544196 0.562363305075253 0.73610156192777 Possible glycine betaine transport integral membrane protein BetP III.A.1 - Amino acids Rv0918 - 23.3 22.8 2.9 11.3 0 8.59014015548141 -0.722371427555045 1.14267302378878 -0.632176845446008 0.527271325653745 0.707958694262913 hypothetical protein V - Conserved hypotheticals Rv0919 - 11.7 6 5.8 15.6 0 5.89160045188109 0.745772464283 1.22503641698169 0.608775750618481 0.542673088989725 NA GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv0920c - 34.2 24.2 16.8 15.7 9.2 50.8309065432062 -0.189469082444491 0.483734942054998 -0.39167954590915 0.69529500493675 0.83088222249864 Probable transposase IV.B.1.c - Others Rv0921 - 48.3 44.2 26.8 13.1 6.8 28.4569607417912 -1.29453908175583 0.626961945648974 -2.0647809500078 0.038943731131186 0.116501820441772 Possible resolvase IV.B.1.c - Others Rv0922 - 209.1 116.5 101 113.7 11.9 304.764804686076 -0.645275970403341 0.368789130982617 -1.7497152605448 0.0801674590838896 0.199248328929529 Possible transposase IV.B.1.c - Others Rv0923c - 12 13 5 1.4 3.5 14.2947408713309 -1.30114191038004 0.97484418061183 -1.33471783107267 0.181968715357022 0.354723824873182 hypothetical protein VI - Unknowns Rv0924c mntH 9.1 1.8 3 2.6 2.4 8.6631206064536 -0.220257670790793 1.05174727102084 -0.209420720033822 0.834119819114063 0.912551913218825 Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) III.A.2 - Cations Rv0925c - 76.1 39.8 36.2 51.9 12.7 56.7153982129395 0.0527894777173346 0.446972506270898 0.118104529868646 0.90598483425944 0.953325419995372 hypothetical protein VI - Unknowns Rv0926c - 33.6 34.6 24.4 22.8 9.2 51.6335857432286 -0.224003296314042 0.486518656726479 -0.460420773627139 0.64521422659789 0.796844069250253 hypothetical protein V - Conserved hypotheticals Rv0927c - 26.1 14.2 10.4 11.9 7.5 21.3450104261647 0.0860320600119066 0.678938895954719 0.126715468099569 0.899165602756662 0.950132626779265 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0928 pstS3 43.5 46.2 32.6 47 10.4 74.6868090752318 0.120587217289901 0.439619733074289 0.274298918400744 0.783854915639379 0.885336132396263 Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1) III.A.4 - Anions Rv0929 pstC2 30.9 7.6 14.8 27.5 6.1 31.2140302455673 0.642323089147526 0.592578975434967 1.08394512086097 0.278389132089191 0.474520840163579 Phosphate-transport integral membrane ABC transporter PstC2 III.A.4 - Anions Rv0930 pstA1 35.2 23.6 15 23.6 10.6 38.8504618206796 0.282014824157794 0.513648622947562 0.549042305495647 0.582976417394579 0.752515477555248 Probable phosphate-transport integral membrane ABC transporter PstA1 III.A.4 - Anions Rv0931c pknD 1055.3 605.8 593.9 508.2 185.3 2177.02202720051 -0.326577256488154 0.23260079571706 -1.4040246744702 0.160311502123055 0.325960585832297 Transmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv0932c pstS2 2376.8 1545.2 1142.2 1347.9 435.4 2811.82335543467 -0.156398037048772 0.219966788001506 -0.711007504677031 0.477079585317481 0.665806103701544 Periplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2) III.A.4 - Anions Rv0933 pstB 87 73.5 50.7 36.7 14.6 79.8419788630277 -0.714789429430925 0.413169608668962 -1.73001453745265 0.0836276779222836 0.205131049307984 Phosphate-transport ATP-binding protein ABC transporter PstB III.A.4 - Anions Rv0934 pstS1 113.4 77 73.8 23.4 11.8 118.974302243465 -1.58947500691926 0.390355154394804 -4.07186888407696 4.66374308220773e-05 0.000474683275781028 Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1) III.A.4 - Anions Rv0935 pstC1 144.4 82.8 69.4 15.2 3.9 102.52142783475 -2.61257900824964 0.415400543834308 -6.2893008856814 3.18898846158792e-10 1.03814689247123e-08 Phosphate-transport integral membrane ABC transporter PstC1 III.A.4 - Anions Rv0936 pstA2 62.2 40.5 18 6.3 0 34.372085104043 -2.75396577810952 0.702912856958182 -3.91793342638113 8.93113627824179e-05 0.000819535872993068 Phosphate-transport integral membrane ABC transporter PstA2 III.A.4 - Anions Rv0937c mku 166.7 120.9 92.6 65 30.4 145.10176343933 -0.615429041695993 0.347252708238543 -1.77228003438127 0.0763480837857216 0.190574286658933 DNA end-binding protein, Mku V - Conserved hypotheticals Rv0938 ligD 222.3 161.5 129.2 72.1 23 487.565855148068 -1.11892958929371 0.267228207544581 -4.18716871087438 2.82455869715423e-05 0.000314875620260714 ATP dependent DNA ligase LigD (ATP dependent polydeoxyribonucleotide synthase) (thermostable DNA ligase) (ATP dependent polynucleotide ligase) (sealase) (DNA repair enzyme) (DNA joinase) V - Conserved hypotheticals Rv0939 - 194.3 88.5 94.3 81.8 11.5 302.605613874541 -0.825485637176889 0.346985202898036 -2.37902259313192 0.0173586119967878 0.0624205113630684 Possible bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) + cyclase/dehydrase II.B.6 - Aromatic hydrocarbons Rv0940c - 52.2 34.2 21.3 64.5 26.2 72.2880918435924 1.17747343067439 0.405861818464646 2.9011682723167 0.00371774178034444 0.0180386868301096 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0941c - 46.4 31.5 23.7 50.3 12.3 48.3081596835218 0.629992694342654 0.464591560839258 1.35601407224145 0.175094690683527 0.344738962980018 hypothetical protein VI - Unknowns Rv0942 - 1.1 0 0 1.9 0 0.220215184168605 1.83360503077235 4.42050447967725 0.414795424187924 0.678291669593945 NA Hypothetical protein VI - Unknowns Rv0943c - 4.2 0 0 0.4 0 1.02351694538049 -1.32115634495788 2.93448457869627 -0.450217511637033 0.652553610632879 NA Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0944 - 35.6 26.6 34 7.9 5.7 19.2020485964741 -1.69627380660294 0.788809709523289 -2.15042206773554 0.031521844333408 0.098544018207353 Possible formamidopyrimidine-DNA glycosylase (FAPY-DNA glycosylase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0945 - 45.9 39.8 27 21.6 4.1 35.5808374981775 -0.875829408724049 0.57101484201792 -1.53381198574268 0.125075913475406 0.273299744312085 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0946c pgi 41.1 27.2 23.6 26.8 11.9 84.2625078409668 0.117585028935475 0.389680172431098 0.301747528497273 0.76284453349819 0.875802258232129 Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) I.B.1 - Glycolysis Rv0948c - 136.7 101.3 45.4 90.4 12.5 41.154256154113 -0.179361005896017 0.549343923627398 -0.326500391069532 0.74404579346541 0.863502686911692 Chorismate mutase VI - Unknowns Rv0949 uvrD1 68.4 37.6 32.9 37.9 13.6 163.710646289171 -0.0670963870317677 0.315191647542802 -0.212874889150279 0.831424549030942 0.911171334364974 Probable ATP-dependent DNA helicase II UvrD1 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv0950c - 102.2 76.2 45.9 1.1 0.3 70.0253581679682 -6.15227210598335 0.818509431722749 -7.51643398052777 5.62904854478626e-14 3.98761798912659e-12 hypothetical protein V - Conserved hypotheticals Rv0951 sucC 342.7 220.3 175.2 185.3 73.9 437.776025606974 -0.118129783169567 0.263182111467269 -0.448851871090253 0.653538517148403 0.804320162522461 Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta) I.B.3 - TCA cycle Rv0952 sucD 291.2 183.1 135.9 144.4 75.3 293.535035948758 0.00801911616403633 0.303495538841232 0.0264225174269576 0.978920334108799 0.992876554556417 Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) I.B.3 - TCA cycle Rv0953c - 12.6 0 3.7 6.6 2.3 6.70384933285899 0.439187388554568 1.23394317114522 0.355921892372854 0.721899060238205 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv0954 - 204.9 104.4 83 135.2 28.1 178.48680430317 0.0254084855469864 0.330000530740515 0.0769952869165703 0.9386272943348 0.973096145501906 Probable conserved transmembrane protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv0955 - 91.2 53.2 35.3 61.2 16.9 128.368981042543 0.141462951623678 0.342284260482884 0.413290846105827 0.679393535724909 0.821020779098474 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv0956 purN 31.9 20.4 18.7 23.1 17.8 30.9536827752433 0.643200462383735 0.589949446111025 1.09026369398894 0.275597003150734 0.471577094280145 Probable 5'-phosphoribosylglycinamide formyltransferase PurN (GART) (gar transformylase) (5'-phosphoribosylglycinamide transformylase) I.F.1 - Purine ribonucleotide biosynthesis Rv0957 purH 56.8 27.9 24.2 39.8 9 89.1846786470935 0.167117850784097 0.38507380990771 0.433989137885409 0.664296328827013 0.811917735233016 Probable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC) I.F.1 - Purine ribonucleotide biosynthesis Rv0958 - 47 37.6 19.8 31 8.6 72.6091229572574 -0.0485419026928368 0.418398165966607 -0.116018440426699 0.907637927139055 0.954528960191963 Possible magnesium chelatase IV.K - Chelatases Rv0959 - 42.1 19.6 16.7 28.2 7.3 82.7961085176177 0.193274024825102 0.393677711098389 0.490944799200986 0.623465490376668 0.780875094382658 hypothetical protein VI - Unknowns Rv0959A vapB9 335.8 135.6 157.8 153.6 46.2 64.6448307269879 -0.331377997835874 0.436808556608028 -0.758634401324782 0.448071287880536 0.642277823420826 Possible antitoxin VapB9 ? Rv0960 vapC9 316.2 110 102.9 152.7 49.2 99.7269568414672 0.0364679413279697 0.395835180077192 0.0921291061619586 0.926595463413876 0.965862604888743 Possible toxin VapC9 V - Conserved hypotheticals Rv0961 - 238.4 145.3 116.3 164.1 30.4 83.8859300330409 -0.103642131323127 0.407151246184648 -0.25455437578625 0.79906730132222 0.895380063677097 Probable integral membrane protein VI - Unknowns Rv0962c lprP 2.4 0 1.6 0 0 0.633352106047233 -1.53934725597768 3.49057572743318 -0.441000962643389 0.659212300086716 NA Possible lipoprotein LprP VI - Unknowns Rv0963c - 8.6 2.2 4 1.6 2.5 5.01342855946413 -0.882010147890287 1.38396015632617 -0.637308916632145 0.523923644051384 NA hypothetical protein V - Conserved hypotheticals Rv0964c - 21.7 10.7 12.8 9 4.1 9.45103560394985 -0.667572563525756 0.965340016530689 -0.691541376192948 0.489225388065789 0.677153702434163 Hypothetical protein VI - Unknowns Rv0965c - 56.6 40.5 33.9 49.7 16.2 31.1481853329472 0.292526189581085 0.554688374760938 0.52737032700056 0.597936445322787 0.761959709132992 hypothetical protein V - Conserved hypotheticals Rv0966c - 141.9 60.2 38.1 114.9 31.5 86.431633964448 0.685559551460473 0.41035402582121 1.67065389474007 0.0947900605377612 0.225333150620638 hypothetical protein V - Conserved hypotheticals Rv0967 csoR 87.3 75.9 91 59.6 27.9 48.6475437364014 -0.267554028862092 0.520184481515751 -0.51434450347783 0.607011152240775 0.767594966525107 Copper-sensitive operon repressor CsoR V - Conserved hypotheticals Rv0968 - 108.5 70.5 48.3 98.1 26.9 38.6679818443611 0.443541844298944 0.507555396346907 0.873878688890521 0.382184321566223 0.582736490308895 hypothetical protein V - Conserved hypotheticals Rv0969 ctpV 39.7 20.3 15.4 24.5 4.2 82.5649861601664 -0.0904287171366231 0.41413007608067 -0.218358246260308 0.827149995219395 0.907781430302224 Probable metal cation transporter P-type ATPase CtpV III.A.2 - Cations Rv0970 - 78.2 44.7 29.8 73.9 12.3 53.1540129512133 0.448024423633029 0.475654288828862 0.94191187624133 0.346237759221135 0.547015054800113 Probable conserved integral membrane protein VI - Unknowns Rv0971c echA7 22.1 11.5 1.3 2.5 0 8.16426212104028 -2.21502498935649 1.29706746509612 -1.70771763918414 0.0876887475559141 0.21200924494406 Probable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv0972c fadE12 35.1 22 20 7.1 1.7 32.3216005522439 -1.86045344121566 0.61424986349858 -3.02882190419886 0.0024550936664014 0.0131756693430208 Acyl-CoA dehydrogenase FadE12 I.A.3 - Fatty acids Rv0973c accA2 25.2 8.5 20.8 4.4 1.5 40.9225037331422 -1.99219742197274 0.622701579339069 -3.19928114537182 0.00137770744657919 0.00811953373674459 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.A.3 - Fatty acids Rv0974c accD2 12.1 6.5 7.8 2.9 0.5 14.8927570875883 -1.86303226253185 0.891203613977269 -2.09046758037425 0.0365758176893916 0.110727817312671 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2 I.A.3 - Fatty acids Rv0975c fadE13 14 1.4 13.9 6.3 0 13.2131335951118 -1.05855943830281 1.05977300596461 -0.998854879625188 0.317864996372728 0.516220915704816 Probable acyl-CoA dehydrogenase FadE13 I.A.3 - Fatty acids Rv0976c - 7.7 6.5 5.1 6.9 0 14.2857646217496 -0.27278247058289 0.865736758150513 -0.315087083937199 0.752695534949034 0.87068830332772 hypothetical protein VI - Unknowns Rv0977 PE_PGRS16 13.1 10.1 5.7 11.4 3.4 46.1042260476239 0.39118099812425 0.478826996571061 0.816956856913969 0.413953083644087 0.60965564335441 PE-PGRS family protein PE_PGRS16 IV.C.1.b - PE_PGRS subfamily Rv0978c PE_PGRS17 0.7 0.9 1.1 0.2 0 0.435858191821031 -0.970997103457474 4.06496523691466 -0.23886971889444 0.811206606747648 NA PE-PGRS family protein PE_PGRS17 IV.C.1.b - PE_PGRS subfamily Rv0979c - 0.8 8.3 0 6.9 8.3 2.11822216128899 3.09409974636663 2.09689871303253 1.47555994342328 0.140062065118492 NA Hypothetical protein VI - Unknowns Rv0979A rpmF 305.6 116.1 144 81.4 27.5 39.5098965186398 -1.01414197338631 0.540437692064033 -1.87651969556956 0.060583952793669 0.161084350456701 50S ribosomal protein L32 RpmF ? Rv0980c PE_PGRS18 1.9 0 0.8 0.4 0 1.00168772588549 -0.626499209064778 2.69492527105072 -0.232473685187016 0.816170123573418 NA PE-PGRS family protein PE_PGRS18 IV.C.1.b - PE_PGRS subfamily Rv0981 mprA 288.9 133.2 179.2 167.6 49.4 206.918596647339 -0.175553655948704 0.327692759598189 -0.535726380295875 0.592147668828396 0.758548659309287 Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein) I.J.2 - Two component systems Rv0982 mprB 353.9 183.9 195.3 132.9 64.4 524.29824576656 -0.440551168458164 0.284369691002285 -1.54921984444054 0.121328880624946 0.267922004472295 Two component sensor kinase MprB I.J.2 - Two component systems Rv0983 pepD 304.5 168.9 138.7 152.1 37.1 392.283317523599 -0.396870728780001 0.273393398059062 -1.4516470829126 0.146599760058354 0.305628951189143 Probable serine protease PepD (serine proteinase) (MTB32B) II.B.3 - Proteins, peptides and glycopeptides Rv0984 moaB2 356 161 152 200.5 74.3 192.882014270251 0.116993122864807 0.311730038661418 0.375302692570726 0.707435363885305 0.840287075413062 Possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) I.G.4 - Molybdopterin Rv0985c mscL 21.5 18.8 8.5 43.1 7.7 17.5281571597123 1.38726925179387 0.720304467376639 1.92594842129236 0.0541108144939032 0.148689297856792 Possible large-conductance ion mechanosensitive channel MscL II.C.5 - Other membrane proteins Rv0986 - 30.9 24.7 30.8 40.5 16.3 44.8224870551961 0.710826120425556 0.514322956489513 1.38206181827322 0.166952720780583 0.334429968004262 Probable adhesion component transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv0987 - 41.5 35.2 20.9 47.2 21.5 181.117304598409 0.914053309621208 0.330408989885932 2.7664299023364 0.00566737676060316 0.0254421400330246 Probable adhesion component transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv0988 - 60 41.2 39.1 67.2 19.5 104.052655729381 0.603154793191755 0.363072969534697 1.66124951126144 0.0966633455103273 0.228264495749882 Possible conserved exported protein V - Conserved hypotheticals Rv0989c grcC2 7.4 14.1 0 14.4 6.2 17.7490427115405 1.44725425059481 0.895088560721479 1.6168838639031 0.105903352135076 0.242789432532324 Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv0990c - 8.8 5.8 6.9 39.1 13.6 22.386392038889 2.67182651551484 0.664353715408395 4.02169274220496 5.77813991149448e-05 0.000566929960291231 Hypothetical protein VI - Unknowns Rv0991c - 59 28.6 38.9 243.3 64.1 64.8795377077501 2.56682452250411 0.437037111911887 5.87324154526635 4.27355083187388e-09 1.14673613988616e-07 Conserved serine rich protein VI - Unknowns Rv0992c - 73.4 38.8 27.9 20.2 10 35.366108245592 -0.826894721503983 0.55916047864605 -1.4788146750039 0.139189852621537 0.29521584310508 hypothetical protein V - Conserved hypotheticals Rv0993 galU 98.2 59.4 35.9 67.4 19.9 94.5766502790123 0.21542430197136 0.37574501765292 0.573325771069437 0.566424139288131 0.738415274699507 UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase) (UDPGP) (alpha-D-glucosyl-1-phosphate uridylyltransferase) (uridine diphosphoglucose pyrophosphorylase) I.A.1 - Carbon compounds Rv0994 moeA1 136.4 76.8 43.6 86.8 35 184.478965563479 0.367420859860002 0.329161211331662 1.11623376999239 0.264322082822358 0.4582617803998 Probable molybdopterin biosynthesis protein MoeA1 I.G.4 - Molybdopterin Rv0995 rimJ 49.9 30 47.9 24.8 8.5 36.3397190036186 -0.695540616440015 0.577873030801228 -1.2036218673774 0.228735763591006 0.412726477146889 Ribosomal-protein-alanine acetyltransferase RimJ (acetylating enzyme for N-terminal of ribosomal protein S5) II.A.1 - Ribosomal protein synthesis and modification Rv0996 - 151.4 117.6 84.1 153.4 61.4 249.73923925736 0.659081343317216 0.295610980189069 2.22955636795249 0.0257769092233078 0.084460511072115 Probable conserved transmembrane protein VI - Unknowns Rv0997 - 108.7 99.8 49.1 42.9 8.6 45.2130900037266 -1.00386898817938 0.525259326768681 -1.91118736406841 0.0559805071285711 0.152760366910169 Hypothetical protein VI - Unknowns Rv0998 - 65.3 40.8 19.8 34.8 8.3 58.4688882261289 -0.167998650541945 0.46305635299198 -0.36280389947453 0.716751378720352 0.847091552695191 hypothetical protein VI - Unknowns Rv0999 - 51.5 24.5 16.6 25.2 4.3 29.8661517699247 -0.363260837586304 0.608257608361715 -0.597215443904949 0.550363549405356 0.726570142375614 hypothetical protein VI - Unknowns Rv1000c - 150.6 44.5 62.1 53.5 27.9 76.3482751138985 -0.207355520457614 0.451213348624724 -0.459550944336251 0.645838577218327 0.797337135067032 hypothetical protein ? Rv1001 arcA 96.8 54.6 30.9 65.5 29.7 131.797748282181 0.535855858292308 0.35897152617543 1.49275309939328 0.135501828251772 0.288950918523647 Probable arginine deiminase ArcA (adi) (ad) (arginine dihydrolase) I.A.2 - Amino acids and amines Rv1002c - 23.5 6.2 8.4 13.3 5.6 32.5129062741122 0.419526715596041 0.580448954899945 0.722762461805718 0.469825833376489 0.660952603946471 hypothetical protein II.C.5 - Other membrane proteins Rv1003 - 12.5 4.6 12.6 3.4 4.6 12.8385937061097 -0.624234168082431 0.96337333257135 -0.647967041412991 0.517006267584923 0.701544784749428 hypothetical protein V - Conserved hypotheticals Rv1004c - 32.5 11.9 10 13.5 0.2 25.3866444335928 -0.712482075985526 0.730827990931206 -0.974897082250089 0.329611313580116 0.529951553654458 Probable membrane protein II.C.5 - Other membrane proteins Rv1005c pabB 35.1 20.8 19.1 16.6 7.2 50.2857211827756 -0.301952575562971 0.468237230015506 -0.64487092483648 0.519010834976939 0.701655105911572 Probable para-aminobenzoate synthase component I PABD I.G.2 - Folic acid Rv1006 - 262.8 167.2 123.7 94.9 35.2 414.419841865401 -0.712221380286952 0.26543047102728 -2.68326909691447 0.00729063008942288 0.0314919655813852 hypothetical protein VI - Unknowns Rv1007c metS 54.1 45.3 28.4 44.7 10.1 104.208404981479 0.0555114527561529 0.378064536415497 0.146830626544525 0.883265710183702 0.94007980290874 Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1008 tatD 7.5 2.1 2.8 6.1 0.5 4.1439991313843 0.307244982765351 1.44919789298418 0.21201037087673 0.832098943445596 NA Probable deoxyribonuclease TatD (YJJV protein) V - Conserved hypotheticals Rv1009 rpfB 118.3 66.6 43.1 68.5 5.4 107.116304923312 -0.417781920505623 0.445718863642277 -0.937321604680667 0.348593152994627 0.549251311346516 Probable resuscitation-promoting factor RpfB V - Conserved hypotheticals Rv1010 ksgA 72.6 45.9 30.6 41.6 4.1 61.2855506480765 -0.463526527865734 0.489694649057738 -0.946562370566318 0.343861826233016 0.54487031010848 Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase) II.A.2 - Ribosome modification and maturation Rv1011 ispE 45.9 28.9 11.8 19.2 4.3 33.0678618060004 -0.500123203030158 0.59017337564043 -0.847417426256218 0.396762494698041 0.596237910997226 Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) V - Conserved hypotheticals Rv1012 - 5.9 0 1.6 8 6.7 2.43144070526362 2.37915798895473 1.98341956056224 1.19952330624405 0.230324527957801 NA Hypothetical protein VI - Unknowns Rv1013 pks16 170.5 88.1 90.6 191.8 72.5 416.910198925079 0.990257460759963 0.267262456259386 3.70518730771108 0.000211234576425239 0.00168892295642933 Putative polyketide synthase Pks16 I.I - Polyketide and non-ribosomal peptide synthesis Rv1014c pth 13.3 4.2 3.8 21.6 17.7 17.8505546620943 2.42534131188215 0.786392223660687 3.08413694707215 0.00204143601169857 0.0112061385276325 Probable peptidyl-tRNA hydrolase Pth II.B.1 - RNA Rv1015c rplY 63.4 43.8 26.4 67.1 32.3 63.5086471253485 1.00044072549831 0.431615381364434 2.31789868640847 0.0204548278635246 0.0707529299732463 50S ribosomal protein L25 RplY II.A.1 - Ribosomal protein synthesis and modification Rv1016c lpqT 94.3 66.4 42.3 76.4 19.8 74.8955337478097 0.249859698095216 0.402581477279535 0.620643800563444 0.534834013909875 0.71481338680096 Probable conserved lipoprotein LpqT II.C.1 - Lipoproteins(lppA-lpr0) Rv1017c prsA 132.1 93.9 57.9 90.6 21.7 140.78009275533 -0.0261133910556809 0.34116271027125 -0.0765423367486992 0.938987632892782 0.973096145501906 Probable ribose-phosphate pyrophosphokinase PrsA (phosphoribosyl pyrophosphate synthetase) (PRPP synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv1018c glmU 81.6 46.7 40.9 33.8 7.2 107.371669076135 -0.735569573629692 0.372521599395924 -1.97456892384893 0.048317088573994 0.136692594032817 Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU II.C.3 - Murein sacculus and peptidoglycan Rv1019 - 178.3 126.9 83.2 192.5 63.1 151.542081882124 0.751782735310325 0.320789901283786 2.34353616588841 0.0191019102073623 0.0672554333543512 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv1020 mfd 62.4 42.4 23.1 23.3 9.2 210.802231012469 -0.576119998982795 0.321041314061492 -1.79453538765558 0.0727277555628913 0.183216010102248 Probable transcription-repair coupling factor Mfd (TRCF) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1021 - 89.9 81.9 34.6 40.1 10.4 86.6826573028677 -0.715389539729768 0.42938791062524 -1.66606819155219 0.0956998331256047 0.226707605941319 hypothetical protein V - Conserved hypotheticals Rv1022 lpqU 77.8 52.1 28.3 25.2 14.8 52.95681412407 -0.552143734007766 0.490424974538216 -1.12584750506979 0.260230072405739 0.454280392538752 Probable conserved lipoprotein LpqU II.C.1 - Lipoproteins(lppA-lpr0) Rv1023 eno 76.7 49.5 35.7 30.8 5.1 84.8528067885175 -0.891424015564533 0.420737072400193 -2.11871991806949 0.0341141440203637 0.10416577424149 Probable enolase Eno I.B.1 - Glycolysis Rv1024 - 67.8 48 28.7 17.6 9.9 40.8987860546981 -1.08105114035038 0.534026884037525 -2.02433842314654 0.0429353427741521 0.125063309297736 Possible conserved membrane protein VI - Unknowns Rv1025 - 72.9 40.6 31.8 21.9 0 24.1856108307926 -1.40409252072179 0.728560097763334 -1.92721578498786 0.0539527435853943 0.148600791430378 hypothetical protein VI - Unknowns Rv1026 - 36.4 19.4 13.6 6.3 0 22.0430502395839 -2.04419597283297 0.771838710001388 -2.64847557701439 0.00808556912471684 0.0340941498092227 hypothetical protein III.E - Adaptations and atypical conditions Rv1027c kdpE 17.5 5.1 9.9 26.6 9.1 19.2645180569066 1.46851111206431 0.697941684567846 2.10405990147097 0.0353732220938829 0.107639134584651 Probable transcriptional regulatory protein KdpE I.J.2 - Two component systems Rv1028c kdpD 19 10 10.3 13.1 4.4 55.1343979966907 0.147503405695936 0.444431651357359 0.331892216149409 0.739970648189627 0.861879656654936 Probable sensor protein KdpD I.J.2 - Two component systems Rv1028A kdpF 9.7 10.6 0 10.8 0 0.88856980331737 0.770393110320736 2.83175748592327 0.272054762510695 0.785579912300773 NA Probable membrane protein KdpF ? Rv1029 kdpA 5.1 3.8 1.9 4.7 2.3 12.1698793810764 0.739723967823124 0.839808741039917 0.880824325437646 0.378412911409405 0.579230134923126 Probable potassium-transporting ATPase a chain KdpA (potassium-translocating ATPase a chain) (ATP phosphohydrolase [potassium-transporting] a chain) (potassium binding and translocating subunit A) III.A.2 - Cations Rv1030 kdpB 8.4 7.3 2.7 5.3 0.9 17.1635629677816 -0.350137123731772 0.770972058870006 -0.454150211675582 0.649720715411795 0.801013147925019 Probable potassium-transporting P-type ATPase B chain KdpB (potassium-translocating ATPase B chain) (ATP phosphohydrolase [potassium-transporting] B chain) (potassium binding and translocating subunit B) III.A.2 - Cations Rv1031 kdpC 12.4 7.4 10 8.3 0 6.92710621708168 -0.561945230953727 1.16082595284067 -0.484090857530008 0.628321389364024 NA Probable potassium-transporting ATPase C chain KdpC (potassium-translocating ATPase C chain) (ATP phosphohydrolase [potassium-transporting] C chain) (potassium binding and translocating subunit C) III.A.2 - Cations Rv1032c trcS 19.8 18.6 11.2 7.1 9.2 42.0483218256992 -0.120606718454653 0.599709702434896 -0.201108499604017 0.840613736049771 0.91350881138875 Two component sensor histidine kinase TrcS I.J.2 - Two component systems Rv1033c trcR 31.9 47.2 13.6 20 5.1 32.2627951926234 -0.590890964681441 0.638177725680714 -0.925903460593467 0.354496152727668 0.554445977368376 Two component transcriptional regulator TrcR I.J.2 - Two component systems Rv1034c - 0.8 0 0 1 0 0.134794331362578 1.39059033623594 4.43074404925885 0.31385029710045 0.753634741426698 NA Probable transposase (fragment) IV.B.1.c - Others Rv1035c - 6 3 1.5 6 0 3.37677330216242 0.562744072074476 1.57342213513694 0.357656130232018 0.720600667192269 NA Probable transposase (fragment) IV.B.1.c - Others Rv1036c - 5.4 2.7 2.2 9.8 5.8 3.06086187263911 2.16182090680226 1.66001056629777 1.30229346167576 0.192816085909447 NA Probable IS1560 transposase (fragment) IV.B.1.c - Others Rv1037c esxI 20.3 11.4 10 22.1 0 5.64304696010596 0.318607369903944 1.23925854777375 0.257095156193436 0.797105316703945 NA Putative ESAT-6 like protein EsxI (ESAT-6 like protein 1) V - Conserved hypotheticals Rv1038c esxJ 8 12.1 12.2 18.7 2.4 4.933919979491 0.422670418469537 1.34655990987116 0.313889055638065 0.75360530294801 NA ESAT-6 like protein EsxJ (ESAT-6 like protein 2) V - Conserved hypotheticals Rv1039c PPE15 1.4 0 0.4 2.9 0.8 1.4560854363742 2.09644045525911 2.53771747830671 0.826112628052652 0.408740204868067 NA PPE family protein PPE15 IV.C.2 - PPE family Rv1040c PE8 1.3 0 0 1.4 0 0.563864064728586 1.38469218662391 3.65462794313048 0.37888731990535 0.704771540686704 NA PE family protein PE8 IV.C.1.a - PE subfamily Rv1041c - 137.1 80.9 53 75.6 43.2 133.839681035767 0.306481868679491 0.364454057355264 0.84093416575889 0.400384816868677 0.599442325641651 Probable is like-2 transposase IV.B.1.c - Others Rv1042c - 280.9 164.3 99.4 167.1 65.5 118.909340852286 0.184677874374462 0.355322765297087 0.519746811663056 0.60324005518878 0.76520577719971 Probable is like-2 transposase IV.B.1.c - Others Rv1043c - 59.9 32.2 44.8 14.7 7.7 58.222712337588 -1.35698598369334 0.496412995210634 -2.73358271597534 0.00626493852828483 0.0277380153339811 hypothetical protein VI - Unknowns Rv1044 - 49.7 27.1 15 14.4 10.9 26.2159260707722 -0.492733556438035 0.648606929177332 -0.759679760225502 0.44744602983179 0.642161198405268 hypothetical protein V - Conserved hypotheticals Rv1045 - 52.1 34.3 21.5 45.3 14.3 55.9145063526497 0.489394931403198 0.440724193817247 1.11043355066215 0.266812247380454 0.460940428353949 Hypothetical protein VI - Unknowns Rv1046c - 338.6 216.2 248.1 254.7 168.2 279.595417617287 0.58280019876732 0.351393803598329 1.6585386332922 0.0972087964443984 0.228476149307272 Hypothetical protein VI - Unknowns Rv1047 - 3.8 4.1 0 0.7 0 3.13881495455404 -1.92405706928442 1.82491733143925 -1.05432560485739 0.291733869850554 NA Probable transposase IV.B.1.b - IS1081 Rv1048c - 10.6 7.7 5.5 9.9 6.2 18.4307057686349 0.799822076857184 0.702893126993535 1.13789998243153 0.255162248619207 0.447418160697639 Hypothetical protein VI - Unknowns Rv1049 - 15.2 0 19.2 19.6 13.2 14.6485979997734 1.29006069793719 0.923603448326554 1.39676903575296 0.162483036492382 0.328677849946327 Probable transcriptional repressor protein I.J.1 - Repressors/activators Rv1050 - 1.6 1.9 1.2 2.4 2.2 2.95846334719776 1.42149376678004 1.62911253190006 0.872557137058012 0.382904512112108 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1051c - 1.2 0 0 0 0 0.172807174947927 -0.25937561286276 4.45633197988856 -0.0582038353590628 0.953586265728918 NA hypothetical protein V - Conserved hypotheticals Rv1052 - 78.1 55.8 37.1 65.7 9.2 33.4887046184579 0.0891132894131431 0.563208862037424 0.158224231576849 0.874280110220319 0.935276396979876 Hypothetical protein VI - Unknowns Rv1053c - 0 0 0 1.3 2.8 0.0854208528060269 2.09694716487919 4.43926588087807 0.472363499089273 0.636667353215063 NA Hypothetical protein VI - Unknowns Rv1054 - 68.5 24.3 29 42.8 11.6 19.8631928172896 0.196417001499366 0.684570256479833 0.286920151204601 0.774173460483229 0.881423631580758 Probable integrase (fragment) IV.B.3 - Phage-related functions Rv1055 - 71.4 82 38.3 99.9 61.7 21.8609908102177 1.25629910395325 0.679070081439972 1.85002864695388 0.0643094208223723 0.167858488248226 Possible integrase (fragment) IV.B.3 - Phage-related functions Rv1056 - 19.5 5.7 12.2 11.4 2.6 12.9913166106444 -0.24316208606091 0.860948167021744 -0.282435221277112 0.777609811152363 0.882503669048917 hypothetical protein V - Conserved hypotheticals Rv1057 - 61.2 43.2 45.5 6.5 1.7 61.7051595238214 -2.97966281639495 0.538410597676708 -5.53418307375908 3.12682250371953e-08 7.00962361276871e-07 hypothetical protein V - Conserved hypotheticals Rv1058 fadD14 26.2 8.6 19.3 24.5 8.5 56.3098039816738 0.568112626519929 0.493153826605267 1.15199882038969 0.249321558060905 0.440654256534582 Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1059 - 54.3 32.2 18.8 26.4 3.7 47.3216342451324 -0.510049300423586 0.516238152348781 -0.988011633977385 0.323146950507617 0.522642236848392 hypothetical protein V - Conserved hypotheticals Rv1060 - 54.3 22.2 16.9 81.7 7.2 28.8046734686263 1.09906678181139 0.650929983155375 1.68845622455994 0.0913236853609837 0.218821599985213 hypothetical protein VI - Unknowns Rv1061 - 31.8 30.9 22.7 26.4 9.1 39.5824947566545 0.0264550736536681 0.522041198947384 0.0506762180973661 0.959583527503068 0.983462052782369 hypothetical protein V - Conserved hypotheticals Rv1062 - 15.8 15.1 9.7 13.8 0 14.9303531098081 -0.313495904321361 0.855748829848089 -0.366341025995925 0.714110619826999 0.84554681863609 hypothetical protein V - Conserved hypotheticals Rv1063c - 85.7 43.4 38.5 136 31 142.829560973968 1.28664927290707 0.335925658366339 3.83016075391281 0.000128059572216339 0.00111720937140461 hypothetical protein V - Conserved hypotheticals Rv1064c lpqV 16.2 13.9 6.8 13 4.3 7.64947543031828 0.211815073465952 1.03839762726436 0.203982624675265 0.83836707694639 0.91350881138875 Possible lipoprotein LpqV II.C.1 - Lipoproteins(lppA-lpr0) Rv1065 - 194.2 85.5 82.1 351.4 54.9 164.757756784551 1.3807509507103 0.364040485424786 3.7928499878225 0.000148928132265509 0.00126196996288142 hypothetical protein V - Conserved hypotheticals Rv1066 - 74.3 23.1 26.5 71.1 7.8 26.3243450451868 0.589809085500407 0.662338229473365 0.890495307766506 0.373199986812418 0.574727979691124 hypothetical protein V - Conserved hypotheticals Rv1067c PE_PGRS19 1.8 1.7 1.2 0.1 0 2.75073983751668 -3.77417551862091 1.97440704180139 -1.91154885427144 0.055934084845722 NA PE-PGRS family protein PE_PGRS19 IV.C.1.b - PE_PGRS subfamily Rv1068c PE_PGRS20 5.7 4.8 2.7 1.2 1.1 7.16673941222304 -1.40726729096023 1.17611695177759 -1.19653686551604 0.231487121186653 NA PE-PGRS family protein PE_PGRS20 IV.C.1.b - PE_PGRS subfamily Rv1069c - 59.6 30.6 30.2 25.4 5.9 91.6305000650556 -0.651488480601971 0.392522507337855 -1.65974808685612 0.0969651411871604 0.228264495749882 hypothetical protein V - Conserved hypotheticals Rv1070c echA8 77 68.5 43.1 36.2 15.5 69.2265799517969 -0.513359168265058 0.435313667941566 -1.17928566473123 0.238284444539875 0.425178940412413 Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1071c echA9 48 33.1 11.8 33.6 3 43.2401413595701 -0.121780949883171 0.588147031990511 -0.207058683049065 0.835964028953057 0.913196861927262 Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1072 - 1091.7 533.8 472.9 1495.4 326.9 1270.41249574133 1.0534812983906 0.257821059620977 4.08609482848035 4.38694539995692e-05 0.000453019259669021 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1073 - 278.3 113 108.4 607.3 139.6 436.86365418063 1.87496630153155 0.29034672891231 6.45768012801626 1.06320168074591e-10 3.96406352968634e-09 hypothetical protein V - Conserved hypotheticals Rv1074c fadA3 364 247.4 205.9 201.9 73.7 498.975639275414 -0.216328412558046 0.258647503849554 -0.836383144388962 0.402939391962814 0.601184214967265 Probable beta-ketoacyl CoA thiolase FadA3 I.A.3 - Fatty acids Rv1075c - 19.3 10.4 10 43 11.5 37.1312621189908 1.79880127795874 0.516674247476373 3.48149977813826 0.000498614194564338 0.0034765580258797 Conserved exported protein V - Conserved hypotheticals Rv1076 lipU 58.6 27 33.8 119.2 45.2 114.219635586498 1.84077016240693 0.358897057241102 5.12896421207023 2.91340716539643e-07 5.27727430541885e-06 Possible lipase LipU II.B.5 - Esterases and lipases Rv1077 cbs 182.6 77.6 74 113 36.8 250.353690167382 0.232365500987001 0.298638445644269 0.778083010999159 0.436520077500416 0.631598902984671 Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) I.D.3 - Serine family Rv1078 pra 155.5 89.2 76.2 179.2 46.6 153.217110706363 0.798387668789508 0.32001926982427 2.49481123192339 0.0126024153172841 0.0482049190646007 Probable proline-rich antigen homolog Pra V - Conserved hypotheticals Rv1079 metB 75.6 47.3 38.5 64.9 15.4 104.444528817733 0.293477696293362 0.361066737261357 0.812807345587552 0.416328523354294 0.612100983924352 Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase) I.D.2 - Aspartate family Rv1080c greA 1006.5 590 486.3 991.3 366.2 689.342112284305 0.778791273587738 0.24202007115222 3.21787887211186 0.00129142342825522 0.00771369609254638 Probable transcription elongation factor GreA (transcript cleavage factor GreA) II.A.6 - Protein translation and modification Rv1081c - 21.1 6.7 6.3 15.1 6.3 8.67969465578541 0.740004552341387 0.998850388735635 0.740856249030547 0.458780605398964 0.652348817472152 Probable conserved membrane protein VI - Unknowns Rv1082 mca 102.6 77.3 63.9 86 22.9 114.46431017338 0.107422834470098 0.358692827118704 0.299484200264055 0.764570625515628 0.876096305656509 Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) IV.D - Antibiotic production and resistance Rv1083 - 116.6 64.9 50.8 92.2 25.4 33.7217116826959 0.32628873936897 0.536789290383875 0.60785255073854 0.54328527203889 0.722069956308348 hypothetical protein V - Conserved hypotheticals Rv1084 - 35.3 10.5 13.3 22.7 0.7 51.9854564445688 -0.163508226845192 0.597644926351698 -0.273587576227448 0.784401582587448 0.885671152542155 hypothetical protein V - Conserved hypotheticals Rv1085c - 41.6 38.6 26.5 27.7 12.2 41.300544232871 -0.108055921272245 0.516122475753756 -0.209361007025392 0.834166430100494 0.912551913218825 Possible hemolysin-like protein IV.A - Virulence Rv1086 - 178.8 84 64.3 122.5 32.9 137.629931805309 0.27262828010211 0.343640104441007 0.79335408346936 0.427571554757222 0.622465452918241 Short (C15) chain Z-isoprenyl diphosphate synthase (Z-FPP synthase) (Z-farnesyl diphosphate synthase) (Z-FPP synthetase) (Z-farnesyl diphosphate synthetase) (geranyltranstransferase) (farnesyl pyrophosphate synthetase) V - Conserved hypotheticals Rv1087 PE_PGRS21 25.2 10.2 10.6 14.4 7.2 61.2800098862642 0.35542210029218 0.451059928893555 0.787970904806434 0.430713724726214 0.625240988926331 PE-PGRS family protein PE_PGRS21 IV.C.1.b - PE_PGRS subfamily Rv1087A - 0.2 0 0 2 0 0.170841705612054 2.5399620612275 4.42904585943518 0.573478383796055 0.566320831043089 NA hypothetical protein ? Rv1088 PE9 4 4.5 0.8 1.9 4.5 2.2929948055728 1.06262458608061 1.95298775509015 0.544102021792532 0.586371269265497 NA PE family protein PE9 IV.C.1.a - PE subfamily Rv1089 PE10 3.7 13.4 0 1.1 5.4 3.14564379428364 -0.572071707719353 1.87759690177833 -0.304682920587228 0.760607658905099 NA PE family protein PE10 IV.C.1.a - PE subfamily Rv1089A celA2a 2.2 2 9.5 0 0 0.337111234707929 -0.540146991889947 4.45488346974389 -0.121248287538484 0.903494378288365 NA Probable cellulase CelA2a (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) ? Rv1090 celA2b 28.3 16.2 7.8 20 0 9.98272965376407 -0.0832535180064951 1.00156504554101 -0.0831234260591874 0.933753399001026 0.970633353918636 Probable cellulase CelA2b (endo-1,4-beta-glucanase) (endoglucanase) (carboxymethyl cellulase) II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1091 PE_PGRS22 20.2 9.4 11 4.4 2.8 44.056786814316 -1.14413013267516 0.539553999733339 -2.12051089092217 0.0339629840583794 0.103793692437256 PE-PGRS family protein PE_PGRS22 IV.C.1.b - PE_PGRS subfamily Rv1092c coaA 111.5 123.2 70.2 12.2 6.3 103.862890238419 -2.76176662250013 0.466750184045908 -5.91701239099778 3.27842004002145e-09 9.00167735019844e-08 Probable pantothenate kinase CoaA (pantothenic acid kinase) I.G.5 - Pantothenate Rv1093 glyA1 181.8 160.1 104.6 119.5 69.5 334.431068428379 0.247792310886388 0.326067908296263 0.759940811658303 0.447289965195085 0.642161198405268 Serine hydroxymethyltransferase 1 GlyA1 I.D.3 - Serine family Rv1094 desA2 4689.7 2876.8 2226.9 3727.5 1383.9 4850.05817893402 0.468315664800701 0.219200762965351 2.13646913662763 0.0326411940208377 0.101343898893076 Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) I.H.2 - Modification of fatty and mycolic acids Rv1095 phoH2 701.7 420 417.8 555 176.8 1140.35627140244 0.244987026704468 0.24012097129918 1.02026501633306 0.307602790052396 0.503922590616387 Probable PHOH-like protein PhoH2 (phosphate starvation-inducible protein PSIH) I.A.4 - Phosphorous compounds Rv1096 - 110.6 81.1 75.7 127.3 78.3 189.818305048332 1.11548276368978 0.356016603074742 3.1332324224654 0.00172892476961882 0.00975135594584374 Possible glycosyl hydrolase I.A.1 - Carbon compounds Rv1097c - 153.8 125.9 73.3 35.8 6.4 114.168675451929 -1.78625748384837 0.414150765363443 -4.31306092669132 1.61009724285506e-05 0.000197334409487634 Probable membrane glycine and proline rich protein II.C.5 - Other membrane proteins Rv1098c fum 96.8 106 52.6 32.7 11.1 150.697143293269 -1.23902273329571 0.383440393648296 -3.23133074610858 0.00123215272607565 0.00743489770998286 Probable fumarase Fum (fumarate hydratase) I.B.3 - TCA cycle Rv1099c glpX 122.2 80.9 66.1 29.2 21.2 127.946218840803 -0.987362264566845 0.398511463767813 -2.47762575066628 0.0132259793170468 0.0499428771225798 Fructose 1,6-bisphosphatase GlpX V - Conserved hypotheticals Rv1100 - 164.8 117.3 82.7 69.8 11.9 106.488210286937 -0.874104011609269 0.390253969655119 -2.23983374821721 0.025101718035866 0.0828614028732874 hypothetical protein V - Conserved hypotheticals Rv1101c - 125.4 81.6 42.1 83.7 26 153.010408629943 0.197006250335679 0.341032103795782 0.577676553447447 0.56348251175193 0.73658247083737 hypothetical protein II.C.5 - Other membrane proteins Rv1102c mazF3 448.9 315.5 264.2 386 225.5 220.786291164802 0.731718706020784 0.332907781675297 2.19796215738348 0.0279518027874414 0.0899230567421592 Toxin MazF3 V - Conserved hypotheticals Rv1103c mazE3 453.2 267.1 240.9 308.9 96.2 164.702407797093 0.0909462195431919 0.313745889792739 0.289872226225086 0.771913990074354 0.880822113286195 Possible antitoxin MazE3 VI - Unknowns Rv1104 - 33.8 12.8 11.5 22.5 0 16.8384086112488 -0.114672725086949 0.82720609728431 -0.138626547197145 0.889745264225166 0.943363751032937 Possible para-nitrobenzyl esterase (fragment) II.B.5 - Esterases and lipases Rv1105 - 5.3 5.9 5.6 2.9 0 2.97942957913268 -0.943210916545463 1.66675102029236 -0.56589790860306 0.571463183371403 NA Possible para-nitrobenzyl esterase (fragment) II.B.5 - Esterases and lipases Rv1106c - 134.7 88.5 65.2 53.4 21.5 146.634028603037 -0.567685262989892 0.33343630371243 -1.7025298585348 0.0886560861188907 0.213328707223581 3-beta-hydroxysteroid dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1107c xseB 509.4 342.3 230.1 101.1 62.7 112.414795864481 -1.35059316514647 0.398346260196971 -3.39050042663546 0.000697651459361623 0.00459308823245143 Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit) II.B.2 - DNA Rv1108c xseA 192.5 116.2 97.3 47.7 13.1 195.742349807516 -1.42994179583116 0.319125171689556 -4.4808179444466 7.43575193207045e-06 0.000100142332104158 Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit) II.B.2 - DNA Rv1109c - 842.7 639.7 496.5 308.9 145.3 575.172904213347 -0.709971718003088 0.27959293502317 -2.53930492894698 0.0111072967298295 0.0434238907473024 hypothetical protein VI - Unknowns Rv1110 lytB2 402.4 239.2 188.8 240.6 70.7 421.528587328389 -0.0812879875219511 0.258448329129186 -0.314523169083128 0.75312372227346 0.870778893323073 Probable LYTB-related protein LytB2 II.C.3 - Murein sacculus and peptidoglycan Rv1111c - 71 35.7 45.2 32.4 17.8 76.4056948579096 -0.232156929377303 0.431646004395212 -0.537841024852257 0.59068680652086 0.757773512747876 hypothetical protein VI - Unknowns Rv1112 - 11.3 8.5 5.7 7.9 3.8 14.9804327239329 0.230784535443621 0.76388333191494 0.302120135106338 0.762560483629021 0.875802258232129 Probable GTP binding protein V - Conserved hypotheticals Rv1113 vapB32 39.9 16.8 6.1 34.6 6.7 6.77280949791411 0.870591063077093 1.14976651116166 0.757189442052452 0.448936374625176 NA Possible antitoxin VapB32 VI - Unknowns Rv1114 vapC32 24.7 19.4 12.2 11.7 2.6 8.05981245304148 -0.988348686089817 1.09951829247956 -0.898892444855062 0.368709952606518 0.570043933711168 Possible toxin VapC32 Contains PIN domain V - Conserved hypotheticals Rv1115 - 18.1 23 13.8 6 7.3 19.2643581811044 -0.738841886486304 0.794289933089765 -0.930191679016037 0.352271849399346 0.55283424482609 Possible exported protein VI - Unknowns Rv1116 - 12.4 7 2.1 0 0 0.867814002710841 -2.00709356294587 3.10561480739544 -0.646278977729741 0.518098699806254 NA Hypothetical protein VI - Unknowns Rv1116A - 38.4 9.4 13.3 14.1 6.5 7.03169196157455 -0.302061631677419 1.12305235311197 -0.268964871352976 0.787956715436277 NA Conserved hypothetical protein (fragment) ? Rv1117 - 924.2 824.3 480 338.9 94.5 300.891654089537 -1.08195048929134 0.311502466096176 -3.47332880811701 0.000514045176957344 0.00356942448581077 hypothetical protein V - Conserved hypotheticals Rv1118c - 6.5 8.3 3.6 3.6 3 8.19014392817756 -0.0234885118130943 1.05888844104569 -0.0221822345986689 0.982302588841227 0.994090219907322 hypothetical protein VI - Unknowns Rv1119c - 3.1 0.9 1.1 0.8 2.3 0.0987469571131013 0.126759651879696 4.45882529160685 0.0284289344366787 0.977320047179988 NA Hypothetical protein VI - Unknowns Rv1120c - 7 6.7 8.5 1.4 0 3.76010807230459 -2.60966547469838 1.60353515727973 -1.62744512513556 0.103642594233563 NA hypothetical protein V - Conserved hypotheticals Rv1121 zwf1 140.5 97.4 63.1 79 18.4 196.536510866163 -0.339330605183197 0.318900611108543 -1.06406382855033 0.287299785504056 0.48365771875255 Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD) I.B.5 - Pentose phosphate pathway Rv1122 gnd2 163.9 98.6 86.4 55.4 20.3 153.499969473066 -0.864815218170477 0.329437845637871 -2.6251240700533 0.00866173986035354 0.035528959966192 Probable 6-phosphogluconate dehydrogenase,decarboxylating Gnd2 I.B.5 - Pentose phosphate pathway Rv1123c bpoB 51.8 33.2 28.4 28.1 10.8 51.7019548658715 -0.208644334823079 0.459178183337997 -0.454386428611087 0.649550718649217 0.801013147925019 Possible peroxidase BpoB (non-haem peroxidase) III.F - Detoxification Rv1124 ephC 16.7 10 13.6 15.5 2.1 18.9458412069344 -0.0672652769485197 0.74174074484125 -0.090685697686617 0.927742335392869 0.966205043211274 Probable epoxide hydrolase EphC (epoxide hydratase) III.F - Detoxification Rv1125 - 9.2 2.8 5.1 6.6 0 8.99943952722483 -0.116251931010645 1.04927153711467 -0.110792990087504 0.911780504228702 0.957180363360422 hypothetical protein VI - Unknowns Rv1126c - 75.5 45.3 54.4 48.1 3.3 45.7081276062833 -0.646496983823051 0.579587153340319 -1.11544395022752 0.264660224592742 0.458399274086793 hypothetical protein V - Conserved hypotheticals Rv1127c ppdK 94.1 61.2 45.1 46.1 15.4 140.219724926532 -0.352437060347908 0.330654207947397 -1.06587804382026 0.286478775402509 0.483018240837741 Probable pyruvate, phosphate dikinase PpdK I.C.1 - General Rv1128c - 23.4 20.8 11.6 9.8 0.1 28.4321111028866 -1.23154403637639 0.699392066469208 -1.76087790442588 0.0782590704450378 0.195069407119158 hypothetical protein IV.B.2 - REP13E12 family Rv1129c - 5.6 6 5.1 2.4 0 9.08171274359149 -1.45276092461389 1.08242769226373 -1.34213207496167 0.1795531755554 0.351562934116765 Probable transcriptional regulator protein I.J.1 - Repressors/activators Rv1130 prpD 10.7 18.6 2.7 5.9 0 19.1002744367914 -1.16831365345243 0.909096572151669 -1.28513701320778 0.19874440941343 0.376408170638811 Possible methylcitrate dehydratase PrpD V - Conserved hypotheticals Rv1131 prpC 11.4 16.1 5.4 7.7 1.7 16.9520754603463 -0.603127140569879 0.798739972870863 -0.755098231032679 0.450190044502736 0.64349198451521 Probable methylcitrate synthase PrpC I.B.3 - TCA cycle Rv1132 - 24.7 17.9 15.5 12.1 1.1 40.7809026967108 -0.947789711580496 0.578657304457975 -1.63791194594577 0.101440063612584 0.234990650958649 hypothetical protein II.C.5 - Other membrane proteins Rv1133c metE 659.1 314.8 341 261 83.1 1344.81427623372 -0.582193582895435 0.245138137400271 -2.37496127314048 0.017550791498281 0.0630038168855976 Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (methionine synthase, vitamin-B12 independent isozyme) I.D.2 - Aspartate family Rv1134 - 9.2 6.8 5.5 5.4 0 1.84570703976546 -0.421852784671212 1.99388274011518 -0.211573517431042 0.832439771632725 NA Hypothetical protein VI - Unknowns Rv1135c PPE16 8.8 7.4 5.8 8.3 6.4 31.2526972946804 0.919987211895151 0.600378622737395 1.5323450520282 0.125437309178551 0.273751663037848 PPE family protein PPE16 IV.C.2 - PPE family Rv1135A - 4.1 0 0 0.8 0 0.197493914226203 -0.360258545605612 4.45577981803402 -0.0808519631395443 0.93555968269119 NA Possible acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase) ? Rv1136 - 11.8 0 6.3 4.7 0 2.23977426002993 -0.595702325685782 1.97733672888706 -0.301264987891604 0.763212437007466 NA Possible enoyl-CoA hydratase I.A.3 - Fatty acids Rv1137c - 10.3 0 0 3 2.4 1.15634580740719 -0.0912827604518362 2.76579317295211 -0.0330041889409988 0.97367124717081 NA Hypothetical protein VI - Unknowns Rv1138c - 11.6 6.5 3.8 6.7 0.8 8.81999901120537 -0.417279556888619 1.04527967959338 -0.399203739472812 0.689743088077259 0.828440155296593 Possible oxidoreductase V - Conserved hypotheticals Rv1139c - 27.6 10.5 14.1 33.9 11.1 19.0613667237417 1.05027744223857 0.685150881897505 1.53291409233811 0.125297023172675 0.273614091293227 hypothetical protein V - Conserved hypotheticals Rv1140 - 75.6 33 29.9 58.5 19.9 70.5551589007007 0.560912398089919 0.41097079390941 1.36484734779854 0.172301033772166 0.341899306230259 Probable integral membrane protein V - Conserved hypotheticals Rv1141c echA11 48.1 15.4 12 25.9 9.8 32.1640189575956 0.310368961604167 0.583009669648501 0.532356456096671 0.594479137598109 0.759338299809773 Probable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1142c echA10 189.7 117.6 78.8 56.9 12.2 121.508820800967 -1.1530437007736 0.370518868381727 -3.11197026432047 0.00185843217377823 0.010382597412496 Probable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1143 mcr 45 28.7 23.6 23 8.3 50.6954037695923 -0.311365749812112 0.461575589412712 -0.674571526211514 0.499948028429548 0.686356542085852 Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) I.A.3 - Fatty acids Rv1144 - 27.5 17 8.1 17 4.5 18.5487917087799 0.00162828324402872 0.715591628943772 0.00227543640558246 0.998184465989585 0.999585202738999 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1145 mmpL13a 7.5 0.3 2.4 7 0 4.54067305882908 0.744664266923005 1.48730545808552 0.50068011441412 0.616596269497663 NA Probable conserved transmembrane transport protein MmpL13a III.A.6 - Efflux proteins Rv1146 mmpL13b 8.7 6.1 2.5 6.4 0 10.233375174518 -0.11708021983599 0.993870988184916 -0.117802231102259 0.906224361695206 0.953325419995372 Probable conserved transmembrane transport protein MmpL13b III.A.6 - Efflux proteins Rv1147 - 12.5 16.2 3.3 1.2 0 6.61302648708311 -3.03830252594203 1.36258140737265 -2.22981357994641 0.0257598214748765 NA hypothetical protein IV.H - Miscellaneous transferases Rv1148c - 29.5 28.9 25.4 19.5 10 65.8793091606765 -0.173963768809134 0.465544764030824 -0.373677854956213 0.708644002907423 0.841440515688264 hypothetical protein IV.B.2 - REP13E12 family Rv1149 - 309.1 144.2 157.9 147.5 79.1 132.759970434936 0.0201767359350487 0.365144484060581 0.0552568553430516 0.955933834068264 0.980690994096051 Possible transposase IV.B.1.c - Others Rv1151c - 28.7 19.8 18.9 26.8 5.8 25.5519068788258 0.231066781421932 0.613221119500293 0.37680825737089 0.706316103813913 0.839239060620222 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv1152 - 124.7 63.8 85.4 127.6 45.7 66.1893665100557 0.671776093190598 0.429313882661716 1.56476675998837 0.117637608378138 0.262719047210193 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1153c omt 24 15.1 10.9 26.1 16.3 34.7905801458482 1.20797319993551 0.549470142089854 2.19843283083791 0.0279182762555521 0.0898968495428779 Probable O-methyltransferase Omt I.I - Polyketide and non-ribosomal peptide synthesis Rv1154c - 46.2 43.6 21.7 47.6 30.8 53.7816272772094 0.959520590614532 0.491973381933224 1.95035062027963 0.0511343431020526 0.142053210405859 Hypothetical protein VI - Unknowns Rv1155 - 358.6 233.3 157.1 195.5 51.8 157.542462266332 -0.276705693258859 0.326040587233871 -0.84868480825173 0.396056701756341 0.59593578488571 Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) VI - Unknowns Rv1156 - 689.6 352.5 341.4 509.7 190.6 477.979273822897 0.412172596924886 0.259906316424808 1.5858506349311 0.112773196256184 0.254422077158856 hypothetical protein VI - Unknowns Rv1157c - 55.7 30.5 24.6 31.4 9.4 59.9650441344994 -0.109912341432981 0.433248448483245 -0.253693560398824 0.799732309400166 0.895841821598795 Conserved ala-, pro-rich protein V - Conserved hypotheticals Rv1158c - 81 29.9 43.2 31.7 30 61.46641726511 0.246948926630222 0.518550121348302 0.476229618822806 0.633910800444348 0.788105319471352 Conserved hypothetical ala-, pro-rich protein V - Conserved hypotheticals Rv1159 pimE 32.7 17.4 18.6 8.4 3 35.2469406773076 -1.28443238219576 0.561739574512489 -2.28652642696656 0.0222234799001193 0.0753259002930361 Mannosyltransferase PimE II.C.5 - Other membrane proteins Rv1159A - 228 135.4 86.5 442.2 69 103.417030448101 1.40889258818089 0.398912224359173 3.53183608360006 0.00041268507926739 0.00295869392487625 hypothetical protein ? Rv1160 mutT2 56.1 39.2 12.9 34.6 4.6 19.8396144026145 -0.195583966365353 0.750597144130478 -0.260571157104422 0.794423234738696 0.89373135806772 Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1161 narG 608.3 365.7 354.4 850.6 247.8 3658.36058172667 1.01535650019419 0.227363866851431 4.46577776079811 7.97783923576911e-06 0.000106632100275827 Respiratory nitrate reductase (alpha chain) NarG I.B.6.b - anaerobic Rv1162 narH 328.4 200.7 180.5 366.8 122 812.390770755675 0.803814844549534 0.238288709611333 3.3732812849615 0.000742780305048991 0.00482739053299729 Probable respiratory nitrate reductase (beta chain) NarH I.B.6.b - anaerobic Rv1163 narJ 112.5 46.7 46.9 76.2 8.2 58.6530513557543 -0.0464180352971598 0.49307097064721 -0.0941406776315204 0.924997407768812 0.964764669704692 Probable respiratory nitrate reductase (delta chain) NarJ I.B.6.b - anaerobic Rv1164 narI 74.6 49.4 24.6 87.4 14.4 67.2060239734841 0.743926533790139 0.448086584776355 1.66022942677795 0.0968683069088248 0.228264495749882 Probable respiratory nitrate reductase (gamma chain) NarI I.B.6.b - anaerobic Rv1165 typA 81.9 60.3 44.5 36.5 10.6 156.089784728937 -0.688434729870902 0.331063707383289 -2.07946299916791 0.0375748152578908 0.113171765002933 Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein) V - Conserved hypotheticals Rv1166 lpqW 78.2 39 34.2 31.8 8.3 125.723532316397 -0.575688823499083 0.35096009964372 -1.64032556431201 0.100937492972488 0.234430555176933 Probable conserved lipoprotein LpqW II.C.1 - Lipoproteins(lppA-lpr0) Rv1167c - 113.9 92.2 49.5 45.4 23.3 72.0559516785177 -0.536297517661174 0.435535423581612 -1.23135223594661 0.218191152958716 0.401471721444038 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1168c PPE17 69.8 58.6 29.3 58.9 10.6 84.2074349828618 0.0801168954135607 0.422518129294822 0.189617651548526 0.849608754218958 0.918313764859185 PPE family protein PPE17 IV.C.2 - PPE family Rv1169c lipX 25.4 38.8 5.6 39.3 11.5 13.0292632489057 0.83128196453455 0.896903372709212 0.926835587677138 0.354011904541873 0.554169218212823 PE family protein Possible lipase LipX IV.C.1.a - PE subfamily Rv1170 mshB 26.2 13.6 14.6 15.9 4.9 24.2954336367142 -0.127161148571311 0.622224471100857 -0.204365393000912 0.838067971839151 0.91350881138875 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) IV.D - Antibiotic production and resistance Rv1171 - 128 44.2 37.4 90.3 24.3 51.5420911594056 0.533057441146794 0.486415174965401 1.0958898253631 0.27312699224953 0.468720354876599 hypothetical protein VI - Unknowns Rv1172c PE12 101.2 40.7 64.9 120.6 52.9 152.443975175539 1.14601485955066 0.362090826134741 3.16499280521459 0.00155086785984549 0.00891749019411158 PE family protein PE12 IV.C.1.a - PE subfamily Rv1173 fbiC 267.3 159.2 126.8 133.5 30.7 646.310114130329 -0.487588980866405 0.260435576351901 -1.87220573969346 0.061178145326614 0.161831957241872 Probable F420 biosynthesis protein FbiC V - Conserved hypotheticals Rv1174c TB8.4 1312.4 745.8 707.6 1084.7 363.1 547.048584223405 0.416138320714223 0.250742333286362 1.65962530243734 0.0969898549134873 0.228264495749882 Low molecular weight T-cell antigen TB8.4 VI - Unknowns Rv1175c fadH 65.2 26.9 25 28.2 6.1 103.136679292817 -0.437274534239557 0.389935742980085 -1.12140151835706 0.262116990139011 0.455553669809802 Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) I.A.3 - Fatty acids Rv1176c - 24.5 6.1 7.7 27.2 4 12.5096253086305 0.924088396653683 0.887243808591699 1.04152701625551 0.297631021366361 0.493333637261146 hypothetical protein V - Conserved hypotheticals Rv1177 fdxC 2971 1911.4 1493 2854.2 1293 1440.42063107797 0.84438691191967 0.247379505653293 3.4133260541926 0.000641751116765674 0.00428075792012056 Probable ferredoxin FdxC I.B.6.c - Electron transport Rv1178 - 922.9 467.6 414.2 543.1 97 923.587248898931 -0.290684717786943 0.284107350345655 -1.02315099357087 0.306236459644034 0.502403677655938 Probable aminotransferase IV.H - Miscellaneous transferases Rv1179c - 34.7 24.6 18.4 17.3 4.8 99.9806584856584 -0.498566279934203 0.371115638242542 -1.34342568342099 0.179134175106302 0.350936531098739 hypothetical protein VI - Unknowns Rv1180 pks3 94.7 59.6 33.3 70.2 12.1 138.160664508613 0.0935157752404159 0.37019244134779 0.252613951003282 0.800566548268146 0.896209454477172 Probable polyketide beta-ketoacyl synthase Pks3 I.I - Polyketide and non-ribosomal peptide synthesis Rv1181 pks4 99.6 58.8 45.1 32.5 8.5 396.203647303385 -0.988668927169789 0.271996569268099 -3.63485807865205 0.000278133703722653 0.00214629537818222 Probable polyketide beta-ketoacyl synthase Pks4 I.I - Polyketide and non-ribosomal peptide synthesis Rv1182 papA3 307.9 243.2 216 71.5 51.5 469.761042601049 -1.13592176998383 0.344092131307971 -3.301214025633 0.000962674167035437 0.00597161453527061 Probable conserved polyketide synthase associated protein PapA3 I.I - Polyketide and non-ribosomal peptide synthesis Rv1183 mmpL10 146.9 95.7 78.6 17.8 7.1 345.352887697624 -2.37304241893111 0.29685848114556 -7.99385084021747 1.30787982330015e-15 1.32357438117975e-13 Probable conserved transmembrane transport protein MmpL10 II.C.4 - Conserved membrane proteins Rv1184c - 757.3 592 445.4 180.8 89.1 794.634466363998 -1.30487247392784 0.280484241757301 -4.65221313594128 3.2839139521729e-06 4.78667622164462e-05 Possible exported protein V - Conserved hypotheticals Rv1185c fadD21 714.5 636.2 384.1 265.3 124.3 1361.17680268898 -0.715609164402537 0.278419675671603 -2.57025356658558 0.0101624100959608 0.0401732774105951 Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1186c - 20.9 10.5 8.4 28.6 4.1 41.8065417330266 0.94699689018133 0.524100653664883 1.80689889157599 0.0707780454093529 0.179839194289762 hypothetical protein VI - Unknowns Rv1187 rocA 36.3 28 17.1 38.9 9.1 79.2274774425563 0.526592343411 0.401570460773003 1.31133236841509 0.189745497245489 0.365022122784171 Probable pyrroline-5-carboxylate dehydrogenase RocA I.A.2 - Amino acids and amines Rv1188 - 15.5 7 9.4 11.2 0 13.4000785892731 -0.27075915733485 0.893062201893312 -0.303180625896869 0.761752212895802 0.875802258232129 Probable proline dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1189 sigI 12.9 2 5.3 4.2 2.3 7.38120869240162 -0.408351133496572 1.13804843444347 -0.358817007376548 0.719731988740137 0.848914653385803 Possible alternative RNA polymerase sigma factor SigI II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1190 - 5.3 1.9 0.8 2 2.2 3.53958445490517 0.380470142667651 1.54374223810546 0.246459631197615 0.805326450388534 NA hypothetical protein V - Conserved hypotheticals Rv1191 - 32.8 18.8 10.9 12.1 0 20.5885111444971 -1.01701686190598 0.771842448610069 -1.31764826324002 0.187621421199234 0.362352821094704 hypothetical protein V - Conserved hypotheticals Rv1192 - 216 98.3 112.1 162.6 61.1 210.359292916361 0.448224254747478 0.309415252326806 1.44861719445576 0.147444516663229 0.306304092681031 hypothetical protein VI - Unknowns Rv1193 fadD36 72.4 28.1 29.2 36.6 9.6 87.2094315139737 -0.141196750478165 0.401193194781368 -0.351942037688628 0.724881731988215 0.851868312774471 Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1194c - 127.4 69.7 54 112.7 29.9 186.869758386461 0.502210156406975 0.307666360798364 1.63232065768837 0.102611953677246 0.237162061043538 hypothetical protein V - Conserved hypotheticals Rv1195 PE13 1036.6 941.4 1068 613.3 586.1 567.473268364071 0.285667970768486 0.678705635062022 0.420901132996164 0.673827277852142 0.818202337385083 PE family protein PE13 IV.C.1.a - PE subfamily Rv1196 PPE18 771.6 495.5 463.1 316.3 105.9 914.890872179466 -0.707442078305673 0.245990165366671 -2.87589577921201 0.00402882712261762 0.0192319483400426 PPE family protein PPE18 IV.C.2 - PPE family Rv1197 esxK 1078.5 1113.8 974.7 537.6 295.5 468.804025236892 -0.521476791342185 0.341487417419815 -1.5270746877947 0.126742440323399 0.275706020082039 ESAT-6 like protein EsxK (ESAT-6 like protein 3) V - Conserved hypotheticals Rv1198 esxL 1302.1 993.2 686.8 607.9 143.2 373.875435490982 -0.730382177383554 0.287939617591804 -2.53658104949968 0.0111940827396697 0.0436187470450057 Putative ESAT-6 like protein EsxL (ESAT-6 like protein 4) V - Conserved hypotheticals Rv1199c - 4 2.8 1.7 4.2 1.6 6.1331705586178 0.688684969840237 1.13706346461382 0.605669772420431 0.54473406025143 NA Possible transposase IV.B.1.b - IS1081 Rv1200 - 208.2 111.9 98.5 122.1 29.1 259.481022944506 -0.174659608382434 0.293821860455877 -0.594440482105184 0.552217539159754 0.728474682943706 Probable conserved integral membrane transport protein III.A.3 - Carbohydrates, organic acids and alcohols Rv1201c dapD 222.8 137.5 117.7 116.4 33.1 215.327096448949 -0.366503361127285 0.298615653261462 -1.22734142408262 0.219694292362017 0.40280903019061 Tetrahydrodipicolinate N-succinyltransferase DapD V - Conserved hypotheticals Rv1202 dapE 37.5 38.4 17.6 20.4 7.6 46.7956163578397 -0.439308570242957 0.506936382444291 -0.866595070814896 0.386163915249813 0.587035445414093 Probable succinyl-diaminopimelate desuccinylase DapE I.D.2 - Aspartate family Rv1203c - 7.4 8.7 0.7 8.3 0 4.03272242519204 0.435389822682622 1.57452905401176 0.276520666019651 0.782148189013058 NA Hypothetical protein VI - Unknowns Rv1204c - 17.7 11.3 12.5 14.6 0.7 32.1940235392497 -0.259679862858867 0.627599121323354 -0.413767091182834 0.679044687087313 0.820879277018178 hypothetical protein V - Conserved hypotheticals Rv1205 - 106.3 104.8 66.2 51.8 26.7 76.5957746505423 -0.490162518301527 0.436329790016624 -1.12337623860808 0.261277737051677 0.455345779254933 hypothetical protein V - Conserved hypotheticals Rv1206 fadD6 39.8 23.4 15.9 19.7 6.3 66.9105520591464 -0.251044348469901 0.419354281913251 -0.598645010430186 0.549409634125367 0.726392246777547 Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1207 folP2 88.9 62.6 54.3 57 16.3 98.3984142283926 -0.18175654567714 0.371719752952747 -0.488961224775819 0.624869148856737 0.781527727842713 Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2) I.G.2 - Folic acid Rv1208 gpgS 97 58.1 40.9 67.3 17.4 99.0798697400898 0.129095233625971 0.367352476397718 0.351420616220931 0.725272817968171 0.852045214342707 Probable glucosyl-3-phosphoglycerate synthase GpgS V - Conserved hypotheticals Rv1209 - 192.2 124.6 98.6 85.2 47.8 76.856001103711 -0.266259556583698 0.416101043555892 -0.639891585727141 0.522243084608859 0.704395037915461 hypothetical protein V - Conserved hypotheticals Rv1210 tagA 122.5 77.2 60.7 95 48.7 102.380503822863 0.578334651983588 0.374220062420035 1.54543999657199 0.122239872134487 0.269262205908181 Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine glycosidase I) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1211 - 2031.7 1331.9 1182.3 1592.4 1263.7 770.683137583075 0.97868021766942 0.336720524552229 2.90650597842489 0.00365489914706868 0.0177824900809303 hypothetical protein V - Conserved hypotheticals Rv1212c glgA 15.6 13.2 5.5 8.1 3.7 19.1380396366507 -0.213528631853163 0.704042172688647 -0.303289547326014 0.76166921131306 0.875802258232129 Putative glycosyl transferase GlgA II.C.5 - Other membrane proteins Rv1213 glgC 112.2 77.5 55.5 148 53.1 225.865113280093 1.08577614176994 0.290692998828295 3.73513000363411 0.000187618239572602 0.00152418303799577 Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase) I.C.1 - General Rv1214c PE14 37.3 17.7 3.2 21.8 0 7.30150641530657 -0.0140725651585367 1.2188037641673 -0.011546210778362 0.990787661375086 0.996155108273772 PE family protein PE14 IV.C.1.a - PE subfamily Rv1215c - 30.9 17.1 14.3 25.5 9.8 65.0204786248885 0.577778338057255 0.416502855946614 1.38721338835504 0.165376704134194 0.332631377435323 hypothetical protein V - Conserved hypotheticals Rv1216c - 39.3 7.7 8 34.3 5.8 21.7815508944916 0.875940382223318 0.723757305504224 1.21026810446227 0.22617603244716 0.409681298300799 Probable conserved integral membrane protein V - Conserved hypotheticals Rv1217c - 21.3 15.6 9.5 6 1.2 28.1222488920714 -1.40909294843125 0.639264076248293 -2.20424234801511 0.0275073050269079 0.0888967832165217 Probable tetronasin-transport integral membrane protein ABC transporter II.C.5 - Other membrane proteins Rv1218c - 27 13.4 20.6 14.3 2.6 25.7495958647019 -0.604576583017697 0.646571305424909 -0.935050129730681 0.349762465542273 0.550848667385829 Probable tetronasin-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1219c - 48.1 47 29.9 29.8 8.8 37.5555517815876 -0.443586673697261 0.541819038183456 -0.818698942703202 0.412958200017239 0.608950018510016 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1220c - 117.3 71.5 45.8 22.5 6 54.9549298776378 -1.68755151218737 0.485926500015233 -3.4728534297563 0.000514956496964795 0.00356942448581077 Probable methyltransferase IV.H - Miscellaneous transferases Rv1221 sigE 202.2 138.1 83 81.8 50.2 164.082751731206 -0.191137069918224 0.360454134335047 -0.530267381371076 0.595926558945714 0.760912715135443 Alternative RNA polymerase sigma factor SigE II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1222 rseA 488.5 254.9 255.3 541.4 133.7 299.568880118242 0.713935719882135 0.285527645231891 2.50040839058618 0.0124050211721873 0.0476557320953227 Anti-sigma factor RseA VI - Unknowns Rv1223 htrA 441.2 334.8 206.6 360.3 142.3 934.249101336862 0.441470088218347 0.254932979818567 1.73171038338208 0.0833251409698517 0.204672433644393 Probable serine protease HtrA (DEGP protein) II.B.3 - Proteins, peptides and glycopeptides Rv1224 tatB 302.7 218.4 181.4 239.6 45.4 141.228257650125 -0.0696974789133548 0.354342753250261 -0.19669508766313 0.844066154478091 0.915115494080624 Probable protein TatB V - Conserved hypotheticals Rv1225c - 20.9 6.2 15.8 10.4 0 14.3425786879848 -0.834042368633869 0.908520044589228 -0.918023078963511 0.358606783366124 0.559306572735717 hypothetical protein V - Conserved hypotheticals Rv1226c - 25 9.9 16.6 17.3 4.1 39.0185833906026 0.0154345574929143 0.535702540495729 0.0288118056685552 0.977014685227671 0.991856123552998 Probable transmembrane protein II.C.5 - Other membrane proteins Rv1227c - 48.3 29 50.2 18.5 3.7 27.6474519107966 -1.38774887787214 0.686431626635196 -2.02168551684414 0.0432088510484498 0.125756573881355 Probable transmembrane protein II.C.5 - Other membrane proteins Rv1228 lpqX 12.2 16.8 1.9 13.3 1.8 7.67359391205844 0.0594907905328782 1.20620089073504 0.0493207980443668 0.960663645243484 0.983985104390034 Probable lipoprotein LpqX II.C.1 - Lipoproteins(lppA-lpr0) Rv1229c mrp 164 72.6 84.6 68.7 26.4 178.090383057797 -0.374190929841131 0.329169541361002 -1.13677264395114 0.255633342089339 0.447579484765417 Probable Mrp-related protein Mrp V - Conserved hypotheticals Rv1230c - 47.8 24.2 26.5 35 10.3 65.8817585960304 0.177275791742794 0.419929526669528 0.422156053537776 0.67291111608384 0.817591999101511 Possible membrane protein II.C.5 - Other membrane proteins Rv1231c - 110.8 112.8 87 21.2 26 75.5343847643479 -1.26215781527779 0.541508059191434 -2.33082000139095 0.0197628529893956 0.0688045631915934 Probable membrane protein VI - Unknowns Rv1232c - 80.6 27.9 34 40.3 5.4 81.7533861695742 -0.362090223499765 0.449867341228173 -0.804882218191768 0.420887650531489 0.615772019075809 hypothetical protein VI - Unknowns Rv1233c - 234.4 167.5 101.8 55.7 24.7 120.116814262514 -1.28695618043698 0.373455243037801 -3.44607875891225 0.00056878456270816 0.00387429792521597 hypothetical protein VI - Unknowns Rv1234 - 125.7 78.8 72.1 91 14.9 70.7052303965807 -0.160459052220127 0.438371363969766 -0.366034520975676 0.714339316381598 0.84554681863609 Probable transmembrane protein VI - Unknowns Rv1235 lpqY 35.6 22.4 23.7 34.6 14 74.2513803123657 0.590066393691816 0.407022483163123 1.4497144951458 0.147138151907418 0.305847027028212 Probable sugar-binding lipoprotein LpqY II.C.1 - Lipoproteins(lppA-lpr0) Rv1236 sugA 46.2 17.7 24.2 38.1 12.8 49.7164403374597 0.577379108508451 0.474926800988961 1.2157223119566 0.224090721723733 0.408296983716801 Probable sugar-transport integral membrane protein ABC transporter SugA III.A.3 - Carbohydrates, organic acids and alcohols Rv1237 sugB 76.7 43.3 39.5 57.7 12.2 67.6184355038912 0.0932907848729799 0.423741654802312 0.220159580290738 0.825746874555605 0.906913311527428 Probable sugar-transport integral membrane protein ABC transporter SugB III.A.3 - Carbohydrates, organic acids and alcohols Rv1238 sugC 112.7 60.5 73.1 83.7 38.7 176.673714634043 0.378883682506747 0.336622549792567 1.12554456836068 0.260358342322413 0.454280417983244 Probable sugar-transport ATP-binding protein ABC transporter SugC III.A.3 - Carbohydrates, organic acids and alcohols Rv1239c corA 14.5 11 9.3 34.8 12.5 39.4039188774776 1.82236761078065 0.506583002515352 3.59737220106477 0.000321448346528035 0.00240002966342455 Possible magnesium and cobalt transport transmembrane protein CorA III.A.2 - Cations Rv1240 mdh 108.3 67 42 65.3 23.6 112.51949279356 0.089402811947605 0.355355102711311 0.251587246856662 0.801360117149593 0.896375424790883 Probable malate dehydrogenase Mdh I.B.3 - TCA cycle Rv1241 vapB33 92 71.9 28.2 94.4 49.9 37.8160263652312 1.07740616277129 0.546231198528172 1.97243615098217 0.0485598383758327 0.137129302705151 Possible antitoxin VapB33 V - Conserved hypotheticals Rv1242 vapC33 53.1 44.9 34.7 22.2 15 28.0572283800858 -0.515051260413479 0.621159019017325 -0.829177786435898 0.407003812737572 0.604819932769508 Possible toxin VapC33 Contains PIN domain V - Conserved hypotheticals Rv1243c PE_PGRS23 6.2 3.7 4.7 1.4 0 8.71260932626585 -2.06056757591004 1.1283591109961 -1.8261629261725 0.0678257239371701 0.17408602477207 PE-PGRS family protein PE_PGRS23 IV.C.1.b - PE_PGRS subfamily Rv1244 lpqZ 39 16.2 9.3 14.1 0 19.7100325534576 -0.843579494254368 0.800652899994322 -1.05361448670248 0.292059453956508 0.487786456500464 Probable lipoprotein LpqZ II.C.1 - Lipoproteins(lppA-lpr0) Rv1245c - 67.4 32.1 48.6 42.9 11.5 61.9636892613731 -0.158081419942905 0.458106413289342 -0.345075762654866 0.730037414188877 0.854524957388302 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1246c relE 52.3 19.5 29.7 44.5 18.1 18.6157229410439 0.635482531601947 0.701253691600924 0.906209178237872 0.364825145936969 0.566262343080081 Toxin RelE V - Conserved hypotheticals Rv1247c relB 109.8 84.8 74.6 154 71 58.7179679820737 1.12716198580419 0.447665450156938 2.51786682534702 0.011806795350249 0.0456546606229059 Antitoxin RelB V - Conserved hypotheticals Rv1248c - 127.2 67.5 72.3 144.3 57.2 727.011309022312 0.994656771322648 0.257584770647609 3.86147352120982 0.000112705228577356 0.00100301989854521 Multifunctional alpha-ketoglutarate metabolic enzyme I.B.3 - TCA cycle Rv1249c - 74.1 33.1 31.3 58.6 3.9 51.4953896642315 0.0125499766123399 0.547031194423197 0.0229419761437424 0.981696557076226 0.994053081912501 Possible membrane protein II.C.5 - Other membrane proteins Rv1250 - 13.4 5.2 5.8 15.1 4.5 29.1895643089014 1.03085043296721 0.57631467641612 1.78869370354695 0.0736641575508159 0.184917396204812 Probable drug-transport integral membrane protein III.A.6 - Efflux proteins Rv1251c - 14.3 6.3 8.8 10.1 4.7 60.0182534213957 0.375614212817569 0.453813340422111 0.82768437893032 0.407849268032864 0.604865709307802 hypothetical protein VI - Unknowns Rv1252c lprE 16.2 2.8 6.5 30.4 10.5 17.0918889966136 2.03265261809231 0.771697467129118 2.63400193038629 0.00843850081753181 0.0350987925329146 Probable lipoprotein LprE II.C.1 - Lipoproteins(lppA-lpr0) Rv1253 deaD 52.8 33.3 26.4 39.1 21 121.094654541476 0.556059013904739 0.362996196989492 1.5318590622062 0.125557217562632 0.273844621063327 Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1254 - 52 16.9 13.7 45.3 11.9 58.9361229563803 0.856306042375941 0.475672413936425 1.80020118318316 0.0718288770889232 0.181467819293128 Probable acyltransferase IV.H - Miscellaneous transferases Rv1255c - 24 16.8 20.7 13.4 12.6 22.5419459971356 0.144524429519899 0.703051933276893 0.205567217269822 0.837128987404948 0.91350881138875 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1256c cyp130 28.2 19.6 10.5 13.4 5.4 33.8394481509486 -0.300287408720826 0.55072341420203 -0.545259927174019 0.585574760708678 0.754483040505571 Probable cytochrome P450 130 Cyp130 IV.F - Cytochrome P450 enzymes Rv1257c - 89.6 40.3 47.6 47.7 9 110.898615683946 -0.385126950822048 0.387244771821875 -0.994531053344212 0.319964394989863 0.518916614951508 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1258c - 8.1 9 0 10 3.1 14.5208237607 1.02241586889229 0.934723216699504 1.09381670490911 0.274035376128739 0.470040340071668 Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv1259 udgB 10.8 2.6 4.8 6.1 1.4 7.71988177314191 0.0981628459962363 1.05795980951504 0.0927850426012243 0.926074334020271 0.965603559346423 Probable uracil DNA glycosylase, UdgB VI - Unknowns Rv1260 - 80.8 66.1 39 46.4 18.4 105.370408419819 -0.149773632954375 0.372730411751024 -0.401828314064217 0.687810382866664 0.827240874741502 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1261c - 231.6 219.2 118 109.4 37.2 116.834786222877 -0.619255458732298 0.378663073264015 -1.63537324459556 0.101970827653782 0.235911607805157 hypothetical protein V - Conserved hypotheticals Rv1262c - 118.3 47.1 71.4 32.8 18.1 44.6870977254559 -0.909727965683235 0.533722472489057 -1.70449627395423 0.0882884115767189 0.212588411831909 Hypothetical hit-like protein V - Conserved hypotheticals Rv1263 amiB2 8.8 6.2 5 6.6 4.2 18.1338236594512 0.569701056715207 0.720326912934616 0.790892366348277 0.429006803357347 0.623393457326405 Probable amidase AmiB2 (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1264 - 219.1 127.4 141.7 59.1 16.4 231.966225987271 -1.41399793583031 0.322549744432729 -4.38381353647364 1.16619602297772e-05 0.000148585119186586 Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase) IV.J - Cyclases Rv1265 - 369.2 279.5 151.3 272.6 60.4 277.670921852309 0.000765311100851864 0.31328599234498 0.00244285132291881 0.998050888583668 0.999585202738999 hypothetical protein VI - Unknowns Rv1266c pknH 36.2 31.1 15.2 34.3 14.4 99.2556684012616 0.638347973693329 0.384499077860368 1.66020677408529 0.0968728623633105 0.228264495749882 Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1267c embR 7.2 7 2 7.2 1.6 9.48056069202574 0.461139706286546 0.970406801559995 0.475202467197502 0.634642668740611 0.788738362343595 Probable transcriptional regulatory protein EmbR I.J.1 - Repressors/activators Rv1268c - 6 0 2.1 8.5 0 3.51429859366532 1.25166756829352 1.62817527375374 0.768754806973461 0.442038882150061 NA Hypothetical protein VI - Unknowns Rv1269c - 18 14.2 11.2 6.9 14.5 11.0522697921762 0.395543272140862 0.987960439947644 0.400363472207272 0.688888824323934 0.827739625706974 Conserved probable secreted protein V - Conserved hypotheticals Rv1270c lprA 33.2 36 20 34.7 17.4 42.7477746304156 0.602062724183653 0.516084250973808 1.16659774648734 0.24337285383944 0.431660815372708 Possible lipoprotein LprA II.C.1 - Lipoproteins(lppA-lpr0) Rv1271c - 55.5 67.8 28.6 2.3 0 16.8753836588016 -4.41998928903641 1.07198201564916 -4.12319350932375 3.7365553570203e-05 0.00039744381605303 Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1272c - 48.3 35.3 20.8 10.6 10 88.8505452107792 -0.811513111151544 0.47026651337969 -1.72564511412773 0.0844112778473157 0.206338679182327 Probable drugs-transport transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1273c - 20.3 19.8 8.1 4.8 2.7 34.3767639968594 -1.32188577909217 0.609035827316187 -2.17045651471322 0.02997227947304 0.094787333833489 Probable drugs-transport transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1274 lprB 157.5 110.4 81.9 97.1 46.8 108.719847953989 0.128449727454046 0.368012572073694 0.349036248219052 0.727062096641164 0.853015550282545 Possible lipoprotein LprB II.C.1 - Lipoproteins(lppA-lpr0) Rv1275 lprC 134.4 74.4 54.7 150.7 46.7 99.1957480273678 0.938507648992002 0.360352520333625 2.60441538780721 0.00920311415613026 0.0371269138280335 Possible lipoprotein LprC II.C.1 - Lipoproteins(lppA-lpr0) Rv1276c - 6.7 0 2.5 4.6 0 1.63764653911303 0.434372807829796 2.23798454707404 0.194091066624074 0.84610457642309 NA hypothetical protein VI - Unknowns Rv1277 - 23.6 15.1 14.2 18.9 2.6 31.7420506623534 -0.0927037088789479 0.59180386211056 -0.156646001849899 0.87552384581974 0.93588751858224 hypothetical protein VI - Unknowns Rv1278 - 29.1 20.1 12.8 22.3 7.3 91.2255941497525 0.300300958353934 0.373098995996026 0.804882783327386 0.420887324381794 0.615772019075809 Hypothetical protein VI - Unknowns Rv1279 - 72.8 43.9 40.7 34 16.6 125.9209599328 -0.243156811990535 0.357010799946489 -0.681090913851852 0.495813966010902 0.683456496189807 Probable dehydrogenase FAD flavoprotein GMC oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1280c oppA 104.3 69.4 58.9 26.4 10.8 167.991041210548 -1.30295014116096 0.334336475969006 -3.89712231483157 9.73424621331231e-05 0.000884069233014159 Probable periplasmic oligopeptide-binding lipoprotein OppA III.A.1 - Amino acids Rv1281c oppD 28.8 17.8 13.8 8.6 1.4 42.2751402292286 -1.26358392132873 0.533229472709142 -2.36968132108101 0.0178034230605405 0.0637610965424009 Probable oligopeptide-transport ATP-binding protein ABC transporter OppD III.A.1 - Amino acids Rv1282c oppC 32.2 26.7 16.3 10.3 6.8 30.1451349408984 -0.775867177301119 0.613434278941617 -1.26479266636314 0.205945660984503 0.385997981910995 Probable oligopeptide-transport integral membrane protein ABC transporter OppC III.A.1 - Amino acids Rv1283c oppB 34.6 24.2 20 9 2 28.4265453378761 -1.60816052154311 0.637485358096786 -2.52266267941319 0.0116470064369151 0.0451353356669073 Probable oligopeptide-transport integral membrane protein ABC transporter OppB III.A.1 - Amino acids Rv1284 canA 9.2 1.1 4.4 84.7 65.2 51.2410434798832 4.90165258844509 0.633735187178783 7.73454384041056 1.03774515431264e-14 8.54812403854734e-13 Beta-carbonic anhydrase V - Conserved hypotheticals Rv1285 cysD 80.4 46.1 39.9 34.8 7.9 71.1760789178889 -0.660676778537172 0.423240795874532 -1.56099502925287 0.118524923701369 0.264200931246223 Probable sulfate adenylyltransferase subunit 2 CysD I.C.5 - Sulphur metabolism Rv1286 cysN 42.9 26 43.3 25.5 16.7 119.92293005394 0.00452255016996914 0.443081563425112 0.0102070375824462 0.991856103711771 0.996463915980206 Probable bifunctional enzyme CysN/CysC: sulfate adenyltransferase (subunit 1) + adenylylsulfate kinase I.C.5 - Sulphur metabolism Rv1287 - 79.3 45.9 39.3 52.6 8.5 37.2309406609968 -0.1555555769257 0.541689754702949 -0.287167286394411 0.773984233528972 0.881423631580758 hypothetical protein V - Conserved hypotheticals Rv1288 - 16.9 13.4 3.4 4.7 0 15.5811744916987 -1.42013488259285 0.904158432005998 -1.57067039616286 0.116259228985239 0.260791760016286 hypothetical protein V - Conserved hypotheticals Rv1289 - 101.6 62.5 65.4 83.1 20.7 79.060842082807 0.139614160606647 0.401683917630415 0.347572194152678 0.728161491608813 0.853457314122573 hypothetical protein VI - Unknowns Rv1290c - 28.6 17.6 13.5 6.7 2.5 36.0262278015091 -1.38285408108819 0.554868989618561 -2.49221727463779 0.0126948353114785 0.0482976441173544 hypothetical protein VI - Unknowns Rv1290A - 3.1 0 6.8 0 0 1.06070718268034 -2.25007925811519 2.88687435978959 -0.779417105730636 0.435734050590385 NA Hypothetical protein ? Rv1291c - 3.2 10 0 0 0 1.34441830494048 -2.55181933691255 2.68110167695701 -0.951780142783997 0.341208494706321 NA Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1292 argS 72.1 56.6 37.2 36.9 16.2 136.353273534665 -0.269792226095242 0.348262746332332 -0.774680119928164 0.438528701024135 0.633211846321845 Probable arginyl-tRNA synthetase ArgS (ARGRS) (arginine--tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1293 lysA 180.6 107.9 65.2 79.2 31.9 227.423306390456 -0.2378206772084 0.310224797772818 -0.76660756624156 0.443314875538859 0.637782814442989 Diaminopimelate decarboxylase LysA (DAP decarboxylase) I.D.2 - Aspartate family Rv1294 thrA 240.5 131.3 115 92.6 26.7 279.654607665789 -0.704311837739493 0.285092997110238 -2.47046347991198 0.0134938096161717 0.0506303746403392 Probable homoserine dehydrogenase ThrA I.D.2 - Aspartate family Rv1295 thrC 208.9 102.5 100.3 64.4 28.2 193.70241069534 -0.759629157753049 0.320740367426975 -2.36836156249026 0.0178670655804706 0.0639243901879058 Threonine synthase ThrC (ts) I.D.2 - Aspartate family Rv1296 thrB 93.5 43.2 30.1 25.5 6.4 61.300197811965 -0.990779557919034 0.462546413448165 -2.14201111307518 0.032192587775506 0.100286847757997 Probable homoserine kinase ThrB I.D.2 - Aspartate family Rv1297 rho 1116.4 794.1 585.5 1531 466.6 3316.06818714589 0.990494440861193 0.223298535342344 4.43574087641302 9.17561669981688e-06 0.00012004153640229 Probable transcription termination factor Rho homolog II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1298 rpmE 2428.8 2259.7 1386.4 2140.1 509.6 791.710705939877 0.0164545887497331 0.282003899641043 0.0583487986183091 0.953470798020771 0.979180506404631 50S ribosomal protein L31 RpmE II.A.1 - Ribosomal protein synthesis and modification Rv1299 prfA 223.4 143.1 156.7 130.7 23.2 258.193476478565 -0.586310125543547 0.335756899251186 -1.74623403674251 0.0807702926671853 0.20020180309809 Probable peptide chain release factor 1 PrfA (RF-1) II.A.6 - Protein translation and modification Rv1300 hemK 281.9 199.7 129 139 46.3 282.563674573773 -0.363672357092114 0.286163899140995 -1.27085337522931 0.203780816042062 0.383523724984582 Probable HemK protein homolog HemK I.G.12 - Heme and porphyrin Rv1301 - 221 119.7 151.3 86.1 36.3 148.678944429779 -0.655975974343928 0.358991664812876 -1.82727355156241 0.067658649815658 0.173909243575516 hypothetical protein V - Conserved hypotheticals Rv1302 rfe 64.4 36.1 40.1 36.9 8.9 81.3911985502614 -0.327660216719393 0.404627693709121 -0.809781984312082 0.418065488662087 0.613670932797809 Probable undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe (UDP-GlcNAc transferase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1303 - 660.8 371.1 242.4 575.7 113.6 343.952887173872 0.376624407810363 0.303354387097252 1.24153275452588 0.214409005875945 0.395952397712513 hypothetical protein V - Conserved hypotheticals Rv1304 atpB 738.9 627.6 464.4 664.5 445.5 986.998340092086 0.844017448126872 0.318316279035875 2.65150576239222 0.00801337456057829 0.0339108395383134 Probable ATP synthase a chain AtpB (protein 6) I.B.8 - ATP-proton motive force Rv1305 atpE 1315.1 887.6 711.5 2053.2 464.8 527.186415767401 1.01750196513623 0.267937785374674 3.79753069808126 0.000146144682293294 0.00124135363233297 Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) I.B.8 - ATP-proton motive force Rv1306 atpF 1373.5 911.8 800.1 1615.6 524.2 1092.52100303733 0.795414254432815 0.235716710715095 3.37444999983142 0.000739633509735641 0.00481577553581552 Probable ATP synthase B chain AtpF I.B.8 - ATP-proton motive force Rv1307 atpH 1010.9 688.4 654.6 799.2 356.3 1913.02149439242 0.392267422450539 0.256564779665699 1.52892155720539 0.126283891404155 0.275260026679088 Probable ATP synthase delta chain AtpH I.B.8 - ATP-proton motive force Rv1308 atpA 897 538.6 489.6 603.3 176.2 1664.85689823918 -0.00190499266088633 0.228889719428713 -0.00832275327018188 0.993359480325271 0.997584144970828 Probable ATP synthase alpha chain AtpA I.B.8 - ATP-proton motive force Rv1309 atpG 759.3 509.7 448.1 376.2 107.3 730.763581323131 -0.543919952038572 0.250937588561555 -2.16755072508856 0.0301928862985901 0.0952299227690169 Probable ATP synthase gamma chain AtpG I.B.8 - ATP-proton motive force Rv1310 atpD 963.5 594.7 477.1 307.7 101 1245.64723826667 -0.966068515140538 0.230554580939481 -4.19019440517698 2.78715556632835e-05 0.000313400159236032 Probable ATP synthase beta chain AtpD I.B.8 - ATP-proton motive force Rv1311 atpC 1330.4 814.9 608.9 437.8 97.5 406.833189954796 -1.07518244697068 0.281583213926639 -3.81834709525973 0.000134348813809573 0.00115781873117642 Probable ATP synthase epsilon chain AtpC I.B.8 - ATP-proton motive force Rv1312 - 502.3 330.7 241.3 154.8 39.5 190.596845105775 -1.16019147013246 0.321440221480915 -3.60935375413603 0.000306960770478048 0.00231824104271481 Conserved hypothetical secreted protein V - Conserved hypotheticals Rv1313c - 34.5 12.8 9.2 27.4 10.7 49.587597649911 0.886971219913822 0.491369144822995 1.80510158046927 0.0710587878093568 0.18029385846758 Possible transposase IV.B.1.c - Others Rv1314c - 54.2 46.8 26.2 18.4 18.4 38.4124587376843 -0.30360422308544 0.596375976889906 -0.509081912837491 0.610694809262155 0.769779720429378 hypothetical protein V - Conserved hypotheticals Rv1315 murA 60.9 39.1 21.3 59.8 14.1 91.4545072306259 0.628765052259715 0.387943724893859 1.62076355902327 0.105068356571635 0.241814242350053 Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA II.C.3 - Murein sacculus and peptidoglycan Rvnr01 rrs 11779.3 10136.9 12635.9 8847.7 12297.9 43609.4604662657 1.0641756611747 0.798412719009754 1.33286411380641 0.18257640106156 0.355517104211131 16S rRNA ? Rv1316c ogt 50.5 45.9 24.4 103.5 28.2 50.9696687283179 1.44072735674358 0.46882320173357 3.07307179213015 0.00211867510508095 0.0115451495726104 Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1317c alkA 33.3 24 15.3 20.6 14.4 67.3941277522425 0.451127666517623 0.456762104778837 0.98766439202757 0.323317038937222 0.522678663585413 Probable bifunctional regulatory protein and DNA repair enzyme AlkA (regulatory protein of adaptative response) (methylphosphotriester-DNA--protein-cysteine S-methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1318c - 16.1 19 8 7.3 1.3 27.5994951119353 -1.10601156476559 0.671375451861271 -1.64738159803038 0.0994796353475991 0.232487594610968 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1319c - 43.3 21.2 21.2 12.7 5.2 58.4035358570496 -0.896861802153364 0.455065824115875 -1.97083972169484 0.04874221165969 0.137346788940829 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1320c - 140.7 82.1 74.5 62.9 18.2 229.795801358794 -0.553457494846211 0.295865923097707 -1.87063616198692 0.0613955287238305 0.162216617313321 Possible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) IV.J - Cyclases Rv1321 - 118.1 71.9 65.8 82.8 20 88.6037001089208 -0.0293415584418912 0.384360526722593 -0.0763386362592537 0.93914968821914 0.973096145501906 hypothetical protein V - Conserved hypotheticals Rv1322 - 95.2 64.2 48 59.5 13.3 29.1639516309418 -0.207010288603081 0.58070463381768 -0.356481206705981 0.721480223795393 0.849224787904526 hypothetical protein VI - Unknowns Rv1322A - 5027.5 3081.1 2476.8 1815.3 1027.9 2321.47089060723 -0.341798547317647 0.27240831956813 -1.25472873904705 0.209577249238948 0.390056125636197 hypothetical protein ? Rv1323 fadA4 610.6 436 316.1 384.2 161.4 865.758290245395 0.0961801972768725 0.252415789305575 0.381038751741621 0.703174493974333 0.837472783341321 Probable acetyl-CoA acetyltransferase FadA4 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv1324 - 708.7 452.2 281.6 296.6 81.6 580.081432015413 -0.595408956257132 0.263553354487324 -2.25915908911631 0.023873490634086 0.0794801399522844 Possible thioredoxin VI - Unknowns Rv1325c PE_PGRS24 23.4 12.1 12.1 7.5 1.1 32.7386529080492 -1.22448901796727 0.608407072503994 -2.01261470043025 0.0441551792449699 0.127984979448186 PE-PGRS family protein PE_PGRS24 IV.C.1.b - PE_PGRS subfamily Rv1326c glgB 122.5 69.3 62.2 69 40.1 322.41469108003 0.2956258520769 0.311378485890694 0.949410012163383 0.342412120134057 0.544599788735891 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) II.A.8 - Polysaccharides (cytoplasmic) Rv1327c glgE 138.1 80.6 106.7 75.4 47.3 388.370735819645 0.0850769911427415 0.346019791176535 0.245873193707976 0.805780395260357 0.897789921362751 Probable glucanase GlgE II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1328 glgP 79.2 47.9 41.6 36.9 6 187.220995728764 -0.740092771182828 0.343950738149446 -2.15174061019535 0.0314177897444692 0.0983189810623365 Probable glycogen phosphorylase GlgP II.A.8 - Polysaccharides (cytoplasmic) Rv1329c dinG 24.3 16.1 13.1 9.5 3 46.1888561060877 -0.748164605851734 0.486716200804981 -1.53716807579929 0.124252155828364 0.271667367866706 Probable ATP-dependent helicase DinG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1330c pncB1 25.2 14.2 20.1 14.1 8.3 44.3095728876465 -0.0767911064151545 0.528893217729739 -0.145192080066329 0.884559218866536 0.941156128935197 Nicotinic acid phosphoribosyltransferase PncB1 V - Conserved hypotheticals Rv1331 - 960.4 589.4 405.3 1084.8 251.1 382.124059613723 0.727755705351188 0.278277063438885 2.6152198688521 0.00891700336290869 0.0363034780591064 hypothetical protein V - Conserved hypotheticals Rv1332 - 639.3 380.3 304.9 794.6 255.8 635.844448218816 1.02219689370815 0.240453177771919 4.25112657349762 2.1269791452265e-05 0.000247008528930894 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1333 - 170.1 88.5 74.3 80.3 13.5 148.202762594109 -0.56928054323253 0.362829571801865 -1.56900260473643 0.11664733208641 0.261058638720299 Probable hydrolase II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv1334 mec 276.5 231.7 196 92.8 65.9 146.740355455987 -0.723359119892873 0.396760596178033 -1.82316270028057 0.0682787525072702 0.174742298685514 Possible hydrolase V - Conserved hypotheticals Rv1335 cysO 335.1 187 199.4 130.7 74.2 99.2115222007059 -0.437754815248238 0.39695373720641 -1.10278547401762 0.27012033771774 0.465806346736238 Sulfur carrier protein CysO V - Conserved hypotheticals Rv1336 cysM 309 166.5 175.3 68 37.1 260.807884151124 -1.21031485857491 0.327216762570869 -3.69881679980492 0.000216606870434981 0.00172797643036194 Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) I.D.3 - Serine family Rv1337 - 258.4 166.9 133.5 156.3 51.8 206.210474205347 -0.088615903751918 0.297146550663536 -0.298222892219467 0.765533050820693 0.876096305656509 Probable integral membrane protein V - Conserved hypotheticals Rv1338 murI 161.2 98.9 86.9 57.9 22.6 125.016525770262 -0.770124141927383 0.34926066824892 -2.20501250767381 0.0274532168545028 0.0888461147525813 Probable glutamate racemase MurI II.C.3 - Murein sacculus and peptidoglycan Rv1339 - 263.3 148.7 108.9 93.6 36.5 189.85171904827 -0.605528734445143 0.313445903547009 -1.93184446691717 0.0533787057836677 0.147248735113513 hypothetical protein V - Conserved hypotheticals Rv1340 rphA 181.6 124.9 61.3 95.2 37.5 143.843128355806 -0.0610363428290051 0.353429879022099 -0.172697178285791 0.862889461869194 0.926740289848456 Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase) II.B.1 - RNA Rv1341 - 76.2 44.6 42.4 38 18.7 51.05390800146 -0.184215014332542 0.468998539794186 -0.392783769462017 0.694479193319092 0.830500653218631 hypothetical protein V - Conserved hypotheticals Rv1342c - 53.4 24.9 36.6 52.9 11.1 23.4593301395946 0.41627593755253 0.645442911505703 0.644946175923495 0.518962066434788 0.701655105911572 hypothetical protein I.I - Polyketide and non-ribosomal peptide synthesis Rv1343c lprD 48.4 31 27.5 24.6 15.4 22.3763058823501 -0.0103456588949565 0.664768138487565 -0.0155628079866977 0.987583177014506 0.996155108273772 Probable conserved lipoprotein LprD V - Conserved hypotheticals Rv1344 mbtL 44.8 21.1 15.8 20.7 3.6 10.9431969723141 -0.309627396780019 0.90111623242929 -0.343604282818549 0.731143903397771 0.855254856616547 Acyl carrier protein (ACP) MbtL I.H.1 - Synthesis of fatty and mycolic acids Rv1345 mbtM 39.7 20.6 19.7 22.5 5 58.7573743118701 -0.262421722199699 0.448319123971682 -0.585345813212006 0.558315215942465 0.732666445172649 Probable fatty acyl-AMP ligase MbtM I.A.3 - Fatty acids Rv1346 mbtN 58.4 48.4 35.3 35.7 8.9 77.6678721884679 -0.404388992773902 0.414466400134855 -0.9756858279521 0.329220177355594 0.529743627617507 Acyl-CoA dehydrogenase MbtN I.A.3 - Fatty acids Rv1347c mbtK 9.1 4.3 10.5 11.3 2.7 8.62942963192825 0.400702426903975 1.02733795684731 0.39003954271645 0.696507307079554 0.831711165461068 Lysine N-acetyltransferase MbtK IV.D - Antibiotic production and resistance Rv1348 irtA 8.9 6 5.3 6.9 2.9 30.5808628918655 0.293987670598924 0.56138464661954 0.523683133069658 0.600498949005884 0.763722541249135 Iron-regulated transporter IrtA II.C.5 - Other membrane proteins Rv1349 irtB 6.5 7.8 3.2 4.2 0.3 12.0861237920244 -0.792333379447858 0.952113589943523 -0.832183667806756 0.405305281122639 0.603696932605714 Iron-regulated transporter IrtB II.C.5 - Other membrane proteins Rv1350 fabG2 49.3 36.8 22.3 28.3 8.4 38.5171055720215 -0.22214528483522 0.517805655615653 -0.429012859218575 0.667913866551626 0.814652519051605 Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv1351 - 81.4 59.5 28.8 105 26.2 38.0033345344936 0.970563316443636 0.522854596415052 1.85627767853299 0.0634139890142679 0.165887997849732 Hypothetical protein VI - Unknowns Rv1352 - 124.9 76.6 70.2 96.8 60.1 67.4269788142012 0.638892025351644 0.43853808801801 1.45686781332755 0.145152872310154 0.304073036187314 hypothetical protein V - Conserved hypotheticals Rv1353c - 8.3 3.8 2.2 2.5 0 3.38945816862506 -0.852466756254393 1.59888796090378 -0.533162283473904 0.593921247546783 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1354c - 10.1 9.4 7.5 2.9 1.1 19.5613414013269 -1.66426649994783 0.750242042768109 -2.2183060999985 0.0265339685454611 0.0865408071712919 hypothetical protein V - Conserved hypotheticals Rv1355c moeY 12.7 8.4 5.8 6.9 0 22.827059174938 -0.711116658963437 0.735495256864581 -0.966854173873168 0.333616938111382 0.53445101528291 Possible molybdopterin biosynthesis protein MoeY I.G.4 - Molybdopterin Rv1356c - 3.6 2.2 3.2 3.3 0 2.70866949561662 -0.0248454070560988 1.72758188620091 -0.014381608915069 0.988525531833858 NA Hypothetical protein VI - Unknowns Rv1357c - 0.2 0.9 0 0.4 0 0.110107592084302 1.67248802158158 4.43368925467055 0.377222652629464 0.706008147306355 NA hypothetical protein V - Conserved hypotheticals Rv1358 - 2.9 2.5 3.1 1.7 0.6 13.0012157081686 -0.811163186319216 0.870013723938065 -0.932356770934065 0.351152177609818 0.552178724927541 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1359 - 7.5 8.3 7.6 7.5 0 7.72070719125715 -0.391152412691929 1.11682151268773 -0.350237175992953 0.72616070903434 0.85240119701646 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1360 - 320 235.8 166.3 70.9 24.8 286.003142307149 -1.58355335772325 0.298761183685362 -5.30039859324883 1.15550131982684e-07 2.27376981934815e-06 Probable oxidoreductase IV.G - Coenzyme F420-dependent enzymes Rv1361c PPE19 158.6 94.9 75.9 52.2 10 156.227288550353 -1.106930132787 0.347172250338763 -3.18841765638494 0.00143053747255534 0.00834755144611369 PPE family protein PPE19 IV.C.2 - PPE family Rv1362c - 42.2 28.8 12.6 45.4 17.8 39.6401276698256 1.0599403977755 0.521528925919264 2.03237125516522 0.0421160858265408 0.123081828380864 Possible membrane protein V - Conserved hypotheticals Rv1363c - 57.4 59 52.7 40.4 14 67.2270479639399 -0.371425525649186 0.459665001551851 -0.808035252619267 0.419070288609685 0.614454883197863 Possible membrane protein V - Conserved hypotheticals Rv1364c - 36.8 33.1 15.4 41.5 15.8 114.315526193562 0.82500739348498 0.371732818637621 2.21935581719307 0.0264625270060648 0.0863873462262502 Possible sigma factor regulatory protein II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1365c rsfA 45.2 16.3 6.7 37.8 29.9 23.8188084808482 1.53761020200077 0.706550723315405 2.1762205476002 0.0295387731947265 0.0938307431403724 Anti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A) V - Conserved hypotheticals Rv1366 - 15 16.1 12.7 15.4 2.4 17.3830512408842 -0.139178094777899 0.764963283442253 -0.181940882380149 0.855629120406738 0.921719500493178 Hypothetical protein VI - Unknowns Rv1366A - 55.1 57.5 26 67.8 2.8 17.3506304133668 0.151442163488787 0.822508962378013 0.184122204639499 0.853917587481084 0.920462030952677 hypothetical protein ? Rv1367c - 19 7.5 8.7 16.9 12.5 34.1208568726422 1.26180435334956 0.581819754387201 2.1687203705872 0.0301039198807689 0.0950968684200131 hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv1368 lprF 95.4 82.3 48.9 57.7 34.9 101.816832232982 0.172650734548503 0.404313681427028 0.427021746924642 0.66936348811389 0.815858731899311 Probable conserved lipoprotein LprF II.C.1 - Lipoproteins(lppA-lpr0) Rv1369c - 5.6 6 1.7 4.6 2 6.46076237473038 0.301879265319569 1.14362515101817 0.26396696946618 0.791805370829638 NA Probable transposase IV.B.1.a - IS6110 Rv1370c - 10.8 10.2 0 4 0 2.2899440938144 -0.809340803137434 1.98692629037703 -0.407333078764517 0.683763370798779 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1371 - 1.3 1.2 0 0.6 0 1.02532960401582 -0.100981235354553 2.67035995718666 -0.0378155892739425 0.969834714819393 NA Probable conserved membrane protein VI - Unknowns Rv1372 - 31.6 15.1 14 15.1 8.7 38.1505186422166 0.038356685966809 0.52993448246046 0.0723800530750911 0.942299458493595 0.973691654363404 hypothetical protein I.I - Polyketide and non-ribosomal peptide synthesis Rv1373 - 29.2 15.1 15.2 20.8 9.5 34.1384698805539 0.350717169471207 0.536610815972952 0.653578271312527 0.513383546969287 0.697776102596014 Glycolipid sulfotransferase IV.H - Miscellaneous transferases Rv1374c - 6.3 3.8 2.4 4.9 11.8 7.21718089384884 2.2938853926156 1.22435010220888 1.87355347827157 0.0609919952593271 NA Hypothetical protein VI - Unknowns Rv1375 - 56.2 28.2 35.5 124.4 55.5 186.282464457692 1.99287018637683 0.329316594456962 6.05153284080035 1.43474027599641e-09 4.23487504798273e-08 hypothetical protein V - Conserved hypotheticals Rv1376 - 21.5 14.6 14.5 20.8 4.5 41.5735045215063 0.239119290341982 0.509973189409912 0.468886002847848 0.639151121783834 0.792118010272337 hypothetical protein V - Conserved hypotheticals Rv1377c - 53.6 25.1 19.7 35.5 6.2 30.1706282096425 0.0765708178526088 0.585441586376605 0.130791559114409 0.895940200486224 0.947855492868042 Putative transferase IV.H - Miscellaneous transferases Rv1378c - 135 102.4 71.7 45.6 11 179.491716910325 -1.15644046434331 0.333132226526787 -3.47141576904847 0.000517721724228048 0.00358158270940575 hypothetical protein V - Conserved hypotheticals Rv1379 pyrR 67.7 37.5 27.7 54.3 5.9 37.1206529299329 0.0516940715188941 0.574117047814487 0.0900409972420779 0.928254636035189 0.966454415295896 Probable pyrimidine operon regulatory protein PyrR I.J.1 - Repressors/activators Rv1380 pyrB 11.7 5.9 5.9 8.5 2 10.7028386676428 0.0910565802539587 0.897542302263775 0.101451017990234 0.919192438847277 0.960690356564489 Probable aspartate carbamoyltransferase PyrB (ATCase) (aspartate transcarbamylase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1381 pyrC 26.4 14 10.9 8.6 3.8 28.7471472759096 -0.667329598216558 0.594634998520099 -1.12225079229675 0.261755822043104 0.455345779254933 Probable dihydroorotase PyrC (DHOase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1382 - 22.1 12 10.9 13.8 0 8.93400898422089 -0.369976210067206 1.0352031943299 -0.357394772440493 0.720796289683732 0.849224787904526 Probable export or membrane protein VI - Unknowns Rv1383 carA 25.7 8.5 8.8 12 2.9 21.2113751199843 -0.238503414568277 0.688699002812488 -0.346310091337847 0.729109685511696 0.854003474233607 Probable carbamoyl-phosphate synthase small chain CarA (carbamoyl-phosphate synthetase glutamine chain) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1384 carB 55.2 21.6 33.1 13.3 6.7 154.280393120522 -1.08904267559624 0.382791751462976 -2.84500037274594 0.00444113710917119 0.020807549789265 Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1385 pyrF 27.4 8.9 8.9 6.1 0 12.3553745316233 -1.47848583586107 0.956077356331339 -1.54640817091863 0.122006022049754 0.268914331114019 Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (ompdecase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1386 PE15 767.4 518.6 243.3 322 82.9 203.833526238924 -0.572996094259468 0.342284823705183 -1.67403301162134 0.0941241116875598 0.224352357737104 PE family protein PE15 IV.C.1.a - PE subfamily Rv1387 PPE20 579.2 518.3 326.8 196 104.6 1037.77049282116 -0.769772524331707 0.294556054991064 -2.61333118531568 0.0089664367759323 0.0364628232610244 PPE family protein PPE20 IV.C.2 - PPE family Rv1388 mihF 276.1 217.5 130.2 149.3 59.5 178.307831208432 -0.210103941757893 0.324914474174885 -0.64664383540145 0.517862480696362 0.701655105911572 Putative integration host factor MihF II.A.4 - Nucleoproteins Rv1389 gmk 349.8 133.8 91.1 84.2 14.9 130.234331569298 -1.19170656315872 0.418451219471194 -2.84789841134817 0.00440089702952403 0.0206737099185333 Probable guanylate kinase Gmk I.F.1 - Purine ribonucleotide biosynthesis Rv1390 rpoZ 1014.8 562.4 534.2 980.6 388.5 474.668872109167 0.779095381299972 0.260944997709709 2.98566896525331 0.00282958769660894 0.0146099119845319 Probable DNA-directed RNA polymerase (omega chain) RpoZ (transcriptase omega chain) (RNA polymerase omega subunit) VI - Unknowns Rv1391 dfp 395.6 181.5 220.1 338.8 88.9 583.179730748669 0.383549647851354 0.275361046177893 1.39289726406533 0.163650859902048 0.330285667107154 Probable DNA/pantothenate metabolism flavoprotein homolog Dfp I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1392 metK 436.2 239.9 246 198.1 62.4 518.628403265667 -0.493942448870847 0.261420286949443 -1.88945722091711 0.0588305897830621 0.158101630509564 Probable S-adenosylmethionine synthetase MetK (mat) (AdoMet synthetase) (methionine adenosyltransferase) I.D.2 - Aspartate family Rv1393c - 47.5 32.6 28.1 68.7 23 122.366653078566 1.09379380305909 0.339752731516386 3.21938192572365 0.00128467254894253 0.00768633474384197 Probable monoxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1394c cyp132 35.2 31.9 20.4 34.9 19.6 85.4156552260298 0.7690689811415 0.416233358231041 1.8476870388524 0.0646476300543179 0.16849294014157 Probable cytochrome P450 132 Cyp132 IV.F - Cytochrome P450 enzymes Rv1395 - 17.1 12.9 4.1 8.3 0 12.9214439869116 -0.693887117181961 0.932148939898918 -0.744395114859226 0.456637473528583 0.650871212827001 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv1396c PE_PGRS25 344.9 181.3 182.9 184.5 66.1 618.972142736265 -0.129369982755595 0.253980454531231 -0.509369837117474 0.610493014595689 0.769779720429378 PE-PGRS family protein PE_PGRS25 IV.C.1.b - PE_PGRS subfamily Rv1397c vapC10 1949.7 1153.1 1017.9 2081 760.2 1144.77857490042 0.847892098374621 0.232675208674978 3.64410159209972 0.000268327425233127 0.00209804799155791 Possible toxin VapC10 V - Conserved hypotheticals Rv1398c vapB10 10706 4571.7 2783.5 15444.6 2501.2 3437.52375882332 1.2311223036749 0.325391648551395 3.78350922390206 0.000154632591184118 0.00130406818565273 Possible antitoxin VapB10 V - Conserved hypotheticals Rv1399c nlhH 29.1 13.1 11.6 10.3 3.8 22.6732600396852 -0.56204802801864 0.653235117559821 -0.860406939109745 0.389564762069291 0.590178950919345 Probable non lipolytic carboxylesterase NlhH II.B.5 - Esterases and lipases Rv1400c lipI 64.6 7.7 17.9 23.8 6.5 37.8858478839152 -0.146071547625997 0.633853569907188 -0.230449988074353 0.817742121362049 0.903581426877352 Probable lipase LipH II.B.5 - Esterases and lipases Rv1401 - 33.3 36.9 8.8 15.9 1.6 17.784471503118 -0.993494218555131 0.86074004628327 -1.15423259652563 0.24840482203456 0.439309357142768 Possible membrane protein II.C.5 - Other membrane proteins Rv1402 priA 25.4 15.2 16 4.3 0 38.2164087129416 -2.3515457190554 0.651944418394829 -3.6069726999814 0.000309790239701982 0.00232967522085864 Putative primosomal protein N' PriA (replication factor Y) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1403c - 11.5 6.2 8.8 50.6 27.6 45.7619766599594 3.06503343109717 0.529570013866475 5.78777753808015 7.13237822592054e-09 1.81747364577054e-07 Putative methyltransferase IV.H - Miscellaneous transferases Rv1404 - 581.9 363.5 390.2 508.5 177.3 386.820937439079 0.362906447260995 0.280511682767245 1.29373024210944 0.195758615431053 0.372583028402359 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1405c - 49.5 1.8 20.4 113.3 42.3 86.7527121162717 2.63522687480355 1.23423623089117 2.13510737154492 0.0327522406484382 0.101494694992798 Putative methyltransferase IV.H - Miscellaneous transferases Rv1406 fmt 27.8 12.3 16 19.4 2.1 23.9502246447301 -0.207174727738783 0.681404803515223 -0.304040603573694 0.761096957322079 0.875802258232129 Probable methionyl-tRNA formyltransferase Fmt II.A.3 - Aminoacyl tRNA synthases and their modification Rv1407 fmu 27.4 15.2 6.7 12.2 1.4 26.7081333439454 -0.576011659927894 0.67504860824442 -0.853289160059024 0.393498969876209 0.593853153515779 Probable Fmu protein (sun protein) II.A.4 - Nucleoproteins Rv1408 rpe 181.3 176.6 127.2 36 14.1 130.639247457382 -1.9969771573308 0.397358217917664 -5.02563447107212 5.01770822763587e-07 8.71211889327757e-06 Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase) I.B.5 - Pentose phosphate pathway Rv1409 ribG 106.4 62.1 46.5 36.9 10.8 91.8779017490039 -0.8272280850728 0.383117097292462 -2.15920430312019 0.0308343203752833 0.0969078640366048 Probable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase) I.G.9 - Riboflavin Rv1410c - 462 248 213.3 201.8 52.9 641.692117843235 -0.54951031129588 0.253017709851189 -2.17182548849672 0.0298688283781463 0.0945910924602623 Aminoglycosides/tetracycline-transport integral membrane protein III.A.6 - Efflux proteins Rv1411c lprG 849.1 602.4 451.1 337.4 155.8 631.640281052836 -0.517004806759737 0.268844862258029 -1.92306002211615 0.0544725122904156 0.149451307926144 Conserved lipoprotein LprG II.C.1 - Lipoproteins(lppA-lpr0) Rv1412 ribC 41.7 29.7 22.7 12.5 3.3 21.6878997368863 -1.3700578445063 0.697480304438512 -1.96429610382938 0.0494957632674158 0.139027750589363 Probable riboflavin synthase alpha chain RibC (RibE) I.G.9 - Riboflavin Rv1413 - 23.4 13.3 12.3 2.5 0 7.85332699648346 -2.71388724732172 1.1965463540668 -2.26810038582945 0.0233230888684547 0.0783779703719795 hypothetical protein VI - Unknowns Rv1414 - 11.2 0 9.4 4.3 0 2.99941758225182 -0.844852879456882 1.78906889458032 -0.472230489287594 0.636762279367235 NA hypothetical protein VI - Unknowns Rv1415 ribA2 407.6 242.7 185.7 309.7 80.7 580.424487832101 0.205997880336123 0.251933837972694 0.817666582598762 0.413547596993276 0.60956102732913 Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) I.G.9 - Riboflavin Rv1416 ribH 353.5 208.7 209.8 229.1 62.7 189.113403814143 -0.116257474955983 0.313620358997312 -0.370694923402532 0.710864771910371 0.84294711151876 Probable riboflavin synthase beta chain RibH (6,7-dimethyl-8-ribityllumazine synthase) (DMRL synthase) (lumazine synthase) I.G.9 - Riboflavin Rv1417 - 195.1 88.3 82.1 86.3 35.7 83.1947748825971 -0.169281141633816 0.398237430409022 -0.425075918805399 0.67078133205858 0.816743718855789 Possible conserved membrane protein VI - Unknowns Rv1418 lprH 90.2 42.4 39.3 55.9 9.8 55.7628766434184 -0.118044387191853 0.470797617538591 -0.250732762431996 0.80202072884687 0.896420770456174 Probable lipoprotein LprH II.C.1 - Lipoproteins(lppA-lpr0) Rv1419 - 218 131.9 137.8 143.5 91.7 144.02068543988 0.418393108218294 0.372894903980898 1.12201347819901 0.261856709232314 0.455345779254933 hypothetical protein VI - Unknowns Rv1420 uvrC 94.1 45.1 57.6 104.4 26.1 245.509822623882 0.665256511356223 0.313516704226375 2.12191727709626 0.0338446853282222 0.103610955430046 Probable excinuclease ABC (subunit C-nuclease) UvrC II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1421 - 86.5 50.2 32 58 15.9 79.6829340816362 0.171031226999264 0.395811508365609 0.43210271400518 0.665666762240163 0.813312063420027 hypothetical protein V - Conserved hypotheticals Rv1422 - 83 22.2 30.8 45.7 6.2 63.5830770338635 -0.11675507155315 0.502238545076012 -0.232469356838153 0.816173485026306 0.903402026238493 hypothetical protein V - Conserved hypotheticals Rv1423 whiA 70.1 22.7 46.1 38.8 4.4 59.8525778472188 -0.523817418388637 0.538016085316121 -0.973609214826466 0.330250609224419 0.530418644288575 Probable transcriptional regulatory protein WhiA I.J.1 - Repressors/activators Rv1424c - 34.6 22.3 15.6 24.4 10.4 31.0639068380448 0.29553506488784 0.554668649653768 0.532813716932294 0.594162537585179 0.759338299809773 Possible membrane protein II.C.5 - Other membrane proteins Rv1425 - 124.1 62.2 58.1 68.7 32.6 185.403209838104 0.182282794901167 0.323425932685967 0.563599812134284 0.57302651471 0.743263052300572 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv1426c lipO 43.9 15.8 20.8 6 8.4 44.8199243477276 -0.929713315008297 0.619929054975225 -1.49970921276702 0.133689743093046 0.286987315173072 Probable esterase LipO II.B.5 - Esterases and lipases Rv1427c fadD12 56.3 38.9 38.3 18.6 9.3 95.2119312252969 -0.940485696369825 0.403017543123548 -2.33360982025914 0.0196161619147041 0.0685281288221459 Possible long-chain-fatty-acid--CoA ligase FadD12 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1428c - 27.6 19.8 14.3 20.9 0 21.6579019414252 -0.349223213598771 0.747545459067509 -0.46715983538231 0.640385527233848 0.793102978739309 hypothetical protein V - Conserved hypotheticals Rv1429 - 14.9 8.2 9.5 15.3 3.6 23.5940002179972 0.439092705066434 0.63253935557842 0.694174522413566 0.487572768175433 0.675658350890995 hypothetical protein V - Conserved hypotheticals Rv1430 PE16 6 3.8 3.7 1.9 2.4 11.3864545680857 -0.270992557667277 0.942715681255755 -0.287459478032972 0.773760524990351 0.881423631580758 PE family protein PE16 IV.C.1.a - PE subfamily Rv1431 - 19.6 17.5 13.8 20.8 10.5 61.1483965702877 0.683199133736162 0.45006120122543 1.51801384317498 0.129010908920655 0.279655226069131 hypothetical protein II.C.5 - Other membrane proteins Rv1432 - 7.1 2.4 1.5 4.3 1.4 7.56107049808602 0.351467149781729 1.06920593097364 0.328717920093912 0.742368908124517 0.86306318073778 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1433 - 21.2 8.5 9.5 31.8 8.1 24.916709370045 1.33092842612582 0.616895745107069 2.15746086219937 0.0309697734572961 0.0972472850937436 Possible conserved exported protein II.C.5 - Other membrane proteins Rv1434 - 29.1 19.2 29.6 38.5 0 5.13245875486514 0.182922457001943 1.31289040157239 0.139328048086013 0.889190926868062 NA Hypothetical protein VI - Unknowns Rv1435c - 467.4 196.7 130.2 442.4 37.3 258.286386682318 0.41406220827659 0.424479181107109 0.975459402264794 0.329332430269269 0.529743627617507 Probable conserved proline, glycine, valine-rich secreted protein V - Conserved hypotheticals Rv1436 gap 690.5 417.3 437.9 351.5 161.8 809.816296060607 -0.165924927757669 0.272525446553012 -0.608841962672992 0.542629196331216 0.721739622007198 Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) I.B.1 - Glycolysis Rv1437 pgk 370.3 247.6 192.3 108.9 42.2 419.867750457002 -1.05009160262559 0.270817976440793 -3.87748116438334 0.00010554349580191 0.000951234254784641 Probable phosphoglycerate kinase Pgk I.B.1 - Glycolysis Rv1438 tpi 233.1 137.1 116.6 65.9 13.2 147.55033805277 -1.34050464890953 0.357643814758503 -3.74815554915916 0.00017813976909282 0.00146058116233049 Probable triosephosphate isomerase Tpi (TIM) I.B.1 - Glycolysis Rv1439c - 40.9 25.9 14.2 46.2 9.3 20.7935403941015 0.786015944294388 0.667211014245473 1.17806200364253 0.238771888438637 0.425631619954531 hypothetical protein VI - Unknowns Rv1440 secG 369.2 268.6 131.1 185.8 16.1 73.5540890135487 -0.684678435075261 0.488416448478873 -1.4018332863433 0.160965036050978 0.326726737932701 Probable protein-export membrane protein (translocase subunit) SecG III.D - Protein and peptide secretion Rv1441c PE_PGRS26 15.2 3.6 6 5.4 2.7 17.0601109265352 -0.253337575648425 0.766131110356544 -0.330671307069787 0.740892777807221 0.862386532695753 PE-PGRS family protein PE_PGRS26 IV.C.1.b - PE_PGRS subfamily Rv1442 bisC 114.8 55.4 60.1 59.3 8.1 231.668929225498 -0.598907505115764 0.359391113720835 -1.66645051101897 0.0956237173834517 0.226707605941319 Probable biotin sulfoxide reductase BisC (BDS reductase) (BSO reductase) I.G.1 - Biotin Rv1443c - 78.5 35.3 30.1 70 16.1 40.1391057350923 0.584026358279814 0.512090223396072 1.14047550919187 0.254088250279849 0.446197611547459 hypothetical protein VI - Unknowns Rv1444c - 97.7 76.1 39.6 37.7 10.6 36.3147487148263 -0.844135552226828 0.552863076159613 -1.5268437857896 0.126799860732253 0.275706020082039 hypothetical protein VI - Unknowns Rv1445c devB 110.9 45.8 49.6 30.2 7.4 59.0640579590487 -1.13886551926085 0.471825106637087 -2.41374505773562 0.0157895060095106 0.0576225273290252 Probable 6-phosphogluconolactonase DevB (6PGL) I.B.5 - Pentose phosphate pathway Rv1446c opcA 129 73.4 51.4 32.4 8.8 87.9913968214459 -1.29052449527493 0.404019366047679 -3.19421444545962 0.00140211921319939 0.00822624925266541 Putative OXPP cycle protein OpcA I.B.5 - Pentose phosphate pathway Rv1447c zwf2 240.6 177.7 159.1 106.1 41.6 415.990092726566 -0.624190305010853 0.283102275575681 -2.20482263429914 0.0274665430982712 0.0888461147525813 Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) I.B.5 - Pentose phosphate pathway Rv1448c tal 365 209.7 201.4 348.6 128.5 566.945388288942 0.670582019865967 0.252875242825887 2.65182946488631 0.00800569653081569 0.0339108395383134 Probable transaldolase Tal I.B.5 - Pentose phosphate pathway Rv1449c tkt 223.6 141.6 107 96.3 48.4 490.867576293693 -0.22508359924823 0.280628704129783 -0.802069054005734 0.42251301467057 0.617384941403944 Transketolase Tkt (TK) I.B.5 - Pentose phosphate pathway Rv1450c PE_PGRS27 3.6 2.6 3.6 0.5 0.5 15.1325839798516 -2.4611575240609 0.922689073952689 -2.66737473493384 0.00764463809078591 0.0327020629439175 PE-PGRS family protein PE_PGRS27 IV.C.1.b - PE_PGRS subfamily Rv1451 ctaB 278.6 171 137.5 183.3 32.1 261.366916424871 -0.223166305137929 0.316336430479831 -0.705471402074754 0.480516922858311 0.669021596212318 Probable cytochrome C oxidase assembly factor CtaB I.B.6.a - aerobic Rv1452c PE_PGRS28 2.6 0 1.5 0.6 0 3.12481674797907 -1.38796144730024 1.77737798886066 -0.780903924769521 0.434859003554554 NA PE-PGRS family protein PE_PGRS28 IV.C.1.b - PE_PGRS subfamily Rv1453 - 2.9 0 2.7 2.9 0.5 3.42455637694608 0.10096606840562 1.67127518821689 0.0604125934002182 0.951827028895061 NA Possible transcriptional activator protein V - Conserved hypotheticals Rv1454c qor 38.2 28.1 19.7 30.6 6 43.4239674129119 0.0796227452864727 0.496759593431157 0.160284262929906 0.872657154963431 0.934952100084837 Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1455 - 3.3 2 1.4 3 2.3 3.40085918487084 1.13577675374429 1.52315403343127 0.745674258030014 0.455864213013549 NA hypothetical protein V - Conserved hypotheticals Rv1456c - 19.8 8.2 1.9 6 0 9.04785381785502 -0.884485547622987 1.13952376332669 -0.776188769456507 0.437637536110959 0.632440698859656 Probable unidentified antibiotic-transport integral membrane ABC transporter II.C.5 - Other membrane proteins Rv1457c - 35.1 20.4 17.8 8.4 7.4 25.0542693522488 -0.966172810495232 0.662299790088132 -1.45881491275524 0.14461605696242 0.303633712958442 Probable unidentified antibiotic-transport integral membrane ABC transporter II.C.5 - Other membrane proteins Rv1458c - 63.1 40.8 29.3 25.3 12 58.6306379285838 -0.476173961474565 0.448396093076949 -1.06194939881613 0.288258657478647 0.484580998950816 Probable unidentified antibiotic-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1459c - 46.6 42.7 21.7 12.2 5.9 79.9639867970679 -1.30342201177734 0.440856040398919 -2.9565706088498 0.00311080996572753 0.0156447311510853 Possible conserved integral membrane protein V - Conserved hypotheticals Rv1460 - 70.2 40.4 39 19.7 5.7 47.0325284851371 -1.28394035325376 0.50252672438757 -2.55496930002778 0.0106197163941121 0.0417480970787402 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1461 - 132 100.1 91 116.5 59.6 535.936255370112 0.56985976061858 0.295799064664122 1.92650967732319 0.0540407646746804 0.148612102855371 hypothetical protein V - Conserved hypotheticals Rv1462 - 70.4 35.7 33.3 46.5 22.6 98.8069072045123 0.402446104362367 0.375155666566113 1.07274430384072 0.28338585641575 0.479805307564333 hypothetical protein V - Conserved hypotheticals Rv1463 - 82.2 36.2 40.3 56.7 21.6 72.9023924348986 0.334336890707525 0.408235440567008 0.818980562400845 0.412797503604955 0.608950018510016 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1464 csd 68.9 38.9 39 31.3 7.7 82.0450593255232 -0.610787443167635 0.401414892676345 -1.52158640426952 0.12811274629738 0.278219097109331 Probable cysteine desulfurase Csd IV.H - Miscellaneous transferases Rv1465 - 86.3 52.3 37.8 33.7 6.4 34.4271794578063 -0.839000482599433 0.568238495146262 -1.47649356698982 0.139811440939446 0.296179499884879 Possible nitrogen fixation related protein V - Conserved hypotheticals Rv1466 - 170.5 56.6 96.3 55.5 21.8 49.335271669189 -0.740661542876814 0.510437332179901 -1.45103325360962 0.146770600734552 0.305628951189143 hypothetical protein V - Conserved hypotheticals Rv1467c fadE15 42.7 23.1 16.7 47.3 19 112.930279998183 1.11056803850388 0.353263664904241 3.14373695580869 0.00166805306447693 0.00948307128376154 Probable acyl-CoA dehydrogenase FadE15 I.A.3 - Fatty acids Rv1468c PE_PGRS29 37.7 7 10.2 47.6 15 53.0645875889566 1.62428570280119 0.525167883802049 3.09288848937578 0.00198218601534391 0.0110006339132206 PE-PGRS family protein PE_PGRS29 IV.C.1.b - PE_PGRS subfamily Rv1469 ctpD 12.7 7.9 4.3 6.3 0 19.0045308901133 -0.707297489623823 0.789382352232769 -0.8960138108272 0.370245387113759 0.571918517730892 Probable cation transporter P-type ATPase D CtpD III.A.2 - Cations Rv1470 trxA 25.9 23 8.4 57.3 43.1 30.4494602861259 2.42630998155827 0.628922862129614 3.85788166984814 0.000114373993182573 0.00101278170963168 Probable thioredoxin TrxA I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv1471 trxB1 37.5 13.3 17.9 57.7 34.1 27.7159234852433 1.86905652154543 0.617455537699383 3.02703013808812 0.00246969333473697 0.013233969427592 Probable thioredoxin TrxB1 I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv1472 echA12 116.5 57.9 80.3 49.8 41.7 123.879678855858 0.0554954832133385 0.432850271973753 0.128209422071713 0.897983243873943 0.949166412951807 Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1473 - 51.8 21.2 30.4 29.1 8.5 83.4326915525416 -0.163636331177462 0.412186121821796 -0.396996217277321 0.691370250069259 0.82955061847741 Probable macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1473A - 15.2 15.6 23 19.6 0 4.37306624524623 -0.127489497484405 1.42648744748169 -0.0893730244240659 0.92878546105433 NA Possible transcriptional regulatory protein ? Rv1474c - 158.4 72.3 78.6 65.5 10.2 71.4541833217894 -0.774290005493441 0.456516534991495 -1.69608315612898 0.0898701330599624 0.21595658839782 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1475c acn 543.7 311.2 342.3 183.1 95 1557.57473462316 -0.624784615750492 0.279368840389286 -2.23641482307006 0.0253246110584973 0.0832866967216318 Probable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase) I.B.3 - TCA cycle Rv1476 - 121.8 76.8 60.7 88.6 23.3 76.5445255622155 0.124137755862925 0.395116176811968 0.314180393383389 0.75338403310383 0.870778893323073 Possible membrane protein VI - Unknowns Rv1477 ripA 241.6 131.3 111.9 153.2 85.1 419.580026059112 0.508724594710195 0.296916175773298 1.71336099619785 0.0866461472070202 0.209918367583629 Peptidoglycan hydrolase IV.A - Virulence Rv1478 - 160.2 63.9 52.3 81.2 35.2 106.19418307929 0.208717901654071 0.383897215042605 0.543681729055802 0.586660507565781 0.754521248292665 Possible invasion protein IV.A - Virulence Rv1479 moxR1 433.3 231.7 227.5 292.1 88.9 541.207202040155 0.102411931498514 0.25414563266619 0.402965537609801 0.686973577050583 0.827076957822286 Probable transcriptional regulatory protein MoxR1 I.J.1 - Repressors/activators Rv1480 - 300.3 124.8 123.2 158.9 30.2 240.922124036095 -0.256553035934603 0.329259190150573 -0.77918261238898 0.435872151093701 0.630919149641965 hypothetical protein V - Conserved hypotheticals Rv1481 - 277.7 128.4 158.8 143.2 33.4 264.938667006643 -0.411686702591328 0.315679311761451 -1.30412949868069 0.192189432638622 0.367766056405186 Probable membrane protein II.C.5 - Other membrane proteins Rv1482c - 1.5 0 0 1 0 0.503129951200834 1.06644310803735 3.82832226054155 0.278566702450617 0.780577369114619 NA hypothetical protein V - Conserved hypotheticals Rv1483 fabG1 210.9 194 132 92.6 50.4 193.546092516 -0.50860475287637 0.351712580997869 -1.44608063616425 0.148154586223437 0.307418596604226 3-oxoacyl-[acyl-carrier protein] reductase FabG1 (3-ketoacyl-acyl carrier protein reductase) (mycolic acid biosynthesis a protein) I.H.1 - Synthesis of fatty and mycolic acids Rv1484 inhA 235.4 100.3 74.9 100.1 20.5 143.622118146548 -0.417304619764065 0.367056048526027 -1.13689618095062 0.25558168883976 0.447579484765417 NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) I.H.1 - Synthesis of fatty and mycolic acids Rv1485 hemZ 52.2 39.9 41.6 20.4 5.2 58.0105744355374 -1.14698383395188 0.483888231728693 -2.37034868538603 0.0177713165363109 0.0637105295259245 Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase) I.G.12 - Heme and porphyrin Rv1486c - 216.5 142.5 106.2 85.1 22.8 172.438739177179 -0.801659446444113 0.321896250953347 -2.49042803098784 0.0127589333221889 0.0484894225613658 hypothetical protein V - Conserved hypotheticals Rv1487 - 265.4 183.8 221.7 91.7 46.2 132.405467102273 -0.941403790575877 0.393999298169375 -2.38935397842049 0.0168780317381939 0.0610643395471734 hypothetical protein V - Conserved hypotheticals Rv1488 - 289.7 205 164.5 226.4 78.8 429.431419793541 0.231132684760187 0.262736282433832 0.879713614804592 0.379014471965403 0.579461267126646 Possible exported conserved protein V - Conserved hypotheticals Rv1489 - 398.9 252.8 174 244.5 78.7 150.937878164672 -0.00425978818443135 0.322759348725144 -0.0131980319121877 0.989469799811002 0.996155108273772 hypothetical protein ? Rv1489A - 245.1 108.6 125 182.1 33.9 56.2554232739866 0.11824910792125 0.466771796898024 0.253333874726548 0.800010221411417 0.895869808485374 hypothetical protein ? Rv1490 - 10.7 9.7 3.6 18.3 4.3 23.0308616898066 1.22634083861969 0.651076854994836 1.88355772319601 0.0596248249769818 0.159389532127147 Probable membrane protein II.C.5 - Other membrane proteins Rv1491c - 151.3 66.2 98.1 57.4 39 123.270780718292 -0.22558693766125 0.415907919962321 -0.542396349849954 0.587545493680457 0.755111080775101 hypothetical protein II.C.5 - Other membrane proteins Rv1492 mutA 93.5 41.2 31.3 29.1 12.7 133.668950637984 -0.55927088621505 0.362222369735059 -1.54399875033703 0.122588635360057 0.269642096722463 Probable methylmalonyl-CoA mutase small subunit MutA (MCM) I.A.3 - Fatty acids Rv1493 mutB 97.9 44.4 57.3 62.5 20.8 240.511205877919 0.076830308547889 0.311627063757894 0.246545687083132 0.805259842448952 0.897686131592986 Probable methylmalonyl-CoA mutase large subunit MutB (MCM) I.A.3 - Fatty acids Rv1494 mazE4 131.9 63.8 72.3 150.6 35.9 52.626940976041 0.773027237362585 0.457985405360367 1.68788618221213 0.0914330796098575 0.218821599985213 Possible antitoxin MazE4 VI - Unknowns Rv1495 mazF4 48.7 26 25.9 19.5 21.3 18.3754776378733 0.0547882911717865 0.753033287117486 0.0727567985493829 0.941999649561661 0.973691654363404 Possible toxin MazF4 V - Conserved hypotheticals Rv1496 - 47.2 22.3 25.6 13.5 5.2 39.4283517957074 -1.04207070914787 0.534104701433178 -1.95106073088602 0.0510498218394229 0.141962191902243 Possible transport system kinase V - Conserved hypotheticals Rv1497 lipL 123.6 86.5 65.7 160.8 43.7 245.212114285952 0.864501784444225 0.288467186214163 2.99688084384892 0.00272757303116054 0.0142283706573941 Probable esterase LipL II.B.5 - Esterases and lipases Rv1498c - 80.2 43.4 34.5 71.4 17.6 56.5189187224459 0.50743732787771 0.440593227901487 1.15171386154662 0.249438674294703 0.440654256534582 Probable methyltransferase IV.H - Miscellaneous transferases Rv1498A - 47.3 20.9 20 59.1 5.1 9.72695321580694 0.64429406721714 1.00100715081744 0.643645818804588 0.519805131512357 0.70219289695529 hypothetical protein ? Rv1499 - 11.2 4.1 3.6 6.1 0 2.74185935008282 -0.119862138773915 1.72947132628692 -0.0693056525147788 0.944746326502705 NA Hypothetical protein VI - Unknowns Rv1500 - 34.1 15.8 14.1 58.5 23.9 66.3561297186502 1.77431497374994 0.422918165591457 4.19540969886818 2.72378789713718e-05 0.000307250214384073 Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1501 - 88.3 40.6 41.9 76.5 30.3 91.9398919165112 0.722080057238849 0.377308775876665 1.91376427850404 0.0556502817105508 0.152211040786696 hypothetical protein V - Conserved hypotheticals Rv1502 - 499.9 427.8 322 243.2 140.2 578.816398632705 -0.228644263282675 0.3092265292853 -0.739407009518649 0.459659887180362 0.652503806127907 Hypothetical protein VI - Unknowns Rv1503c - 39.6 42.4 22.5 19.9 5.2 24.7057752728033 -0.786868455515472 0.654628369217657 -1.20200787579043 0.229360476703584 0.413432472510989 hypothetical protein V - Conserved hypotheticals Rv1504c - 41.9 39 27.3 8.6 5.7 25.2081243735212 -1.80315129321057 0.681937187135493 -2.64416038196243 0.00818938425110001 0.0342603520211156 hypothetical protein V - Conserved hypotheticals Rv1505c - 124.7 118.4 79.5 48 37.1 106.849465426418 -0.494199231096453 0.431862689354617 -1.14434342970214 0.25248123890285 0.444696498197658 hypothetical protein V - Conserved hypotheticals Rv1506c - 66 53.9 38.1 45.1 10.3 38.2083617078075 -0.225678072065337 0.527792451393041 -0.427588669503871 0.668950616568793 0.815636173454963 Hypothetical protein VI - Unknowns Rv1507c - 122.8 104.8 91.9 115.6 51.4 139.851801766909 0.423088899661555 0.358853820700962 1.17900068288285 0.238397903912776 0.425178940412413 hypothetical protein VI - Unknowns Rv1507A - 10.5 0 7.9 10.7 0 4.74127530544153 0.335629508631962 1.4627803388864 0.229446280968935 0.818522068437451 NA Hypothetical protein ? Rv1508c - 75.7 42.4 34 35.8 16.1 137.452846816613 -0.141505582417825 0.340083214024682 -0.416091052372714 0.677343377103717 0.820502818639317 Probable membrane protein II.C.5 - Other membrane proteins Rv1508A - 72.1 50.9 28 47.2 21.3 30.0375609306215 0.263141222176593 0.571279607190205 0.460617215921347 0.645073257811346 0.796844069250253 hypothetical protein ? Rv1509 - 77.5 108.8 57.4 49.3 14.3 99.6151399220497 -0.701248204347955 0.439416859011846 -1.59586094608412 0.110519842549314 0.250294937538153 Hypothetical protein VI - Unknowns Rv1510 - 27.3 8.2 13.5 12.5 0 24.7756903097254 -0.740404085330169 0.744200757764905 -0.994898322267047 0.31978571895022 0.518864414347998 Conserved probable membrane protein II.C.5 - Other membrane proteins Rv1511 gmdA 119.5 79.6 51.6 67.3 23.1 127.646685526754 -0.121321630928736 0.340618586227357 -0.35618030205714 0.721705542592205 0.849224787904526 GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD) I.C.3 - Sugar nucleotides Rv1512 epiA 100.5 47.1 44.2 46.1 18.1 90.0487414900319 -0.214167758841803 0.383035481929564 -0.55913294967589 0.576070988948776 0.745503632757239 Probable nucleotide-sugar epimerase EpiA I.C.3 - Sugar nucleotides Rv1513 - 141.1 111.5 88.1 84.3 24.5 121.081353922569 -0.345424423225715 0.356152916471166 -0.969876722190709 0.332107944279064 0.532274361373957 hypothetical protein V - Conserved hypotheticals Rv1514c - 15.7 12.8 6.3 8.9 2.5 11.7311809088254 -0.346229762990437 0.87516758769134 -0.395615385967136 0.692388784898467 0.829929298176099 hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1515c - 12.4 5.3 9.2 10.9 2.3 11.9675488526609 0.13902335024431 0.876356057060843 0.158637974969411 0.873954107935469 0.935276396979876 hypothetical protein V - Conserved hypotheticals Rv1516c - 11.6 7.8 8.2 8.2 2.4 13.9930470244874 -0.0393879874202545 0.791634151151771 -0.0497552908284057 0.960317395274596 0.983929480492513 Probable sugar transferase IV.H - Miscellaneous transferases Rv1517 - 5.9 9.1 9.1 6.6 2.6 9.08540469319432 -0.263331163426665 1.01918863318928 -0.258373332326754 0.796118795757418 0.894413994739489 hypothetical protein V - Conserved hypotheticals Rv1518 - 7.2 5.3 2.5 2.1 0 4.52410131618021 -1.26183667133282 1.42298652229132 -0.886752370149637 0.375212236056145 NA hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1519 - 2.8 18.3 4.3 9.7 0 2.78638358846264 0.0728911901019221 1.82374299283805 0.0399679068751301 0.968118712442503 NA hypothetical protein V - Conserved hypotheticals Rv1520 - 27.8 18.3 11.4 27 10.4 39.5029085048705 0.776840822683334 0.503205708793424 1.54378380274347 0.122640716493475 0.269642096722463 Probable sugar transferase IV.H - Miscellaneous transferases Rv1521 fadD25 251 143.9 147.9 235.6 128.5 690.897320313821 0.932563026167226 0.289143520249455 3.22525998633022 0.00125858317398012 0.00758146530992789 Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1522c mmpL12 38.2 31.2 21.2 46.9 15.8 213.869129213543 0.801779203232013 0.302827645818737 2.64764203104473 0.00810553031614402 0.0341031352548649 Probable conserved transmembrane transport protein MmpL12 II.C.4 - Conserved membrane proteins Rv1523 - 22 22.8 4.7 12.7 5.7 26.6298198987591 0.0311524472348182 0.677198039879802 0.0460019749028623 0.963308675832829 0.984610856411041 Probable methyltransferase IV.H - Miscellaneous transferases Rv1524 - 21.7 10.1 8.3 14.2 4.6 26.2138475999357 0.208527082498066 0.599538866260437 0.347812450923711 0.727981038330131 0.853457314122573 Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1525 wbbL2 47.1 44.4 20.5 24.2 8.2 40.5263534874255 -0.460185489552747 0.527779820457344 -0.871927026603588 0.38324818855688 0.583855950050955 Possible rhamnosyl transferase WbbL2 I.C.3 - Sugar nucleotides Rv1526c - 16.5 14.8 4.2 8.6 4.6 23.8833860654772 0.0530311059266521 0.677666199153998 0.0782554980503032 0.937624816265265 0.973096145501906 Probable glycosyltransferase IV.H - Miscellaneous transferases Rv1527c pks5 16.2 11.7 5.7 6.2 0.6 82.1343325232554 -1.02639934367155 0.474526498281789 -2.16299689772443 0.030541418223434 0.096157958531025 Probable polyketide synthase Pks5 I.I - Polyketide and non-ribosomal peptide synthesis Rv1528c papA4 3 3.5 1.6 9.2 4 3.78798513597975 2.22347359386768 1.455342415847 1.52780099697268 0.126561954671341 NA Probable conserved polyketide synthase associated protein PapA4 I.I - Polyketide and non-ribosomal peptide synthesis Rv1529 fadD24 15.1 9.8 11.8 13.6 5.9 39.4954639540394 0.385497482340262 0.522021012684883 0.738471197466848 0.460228163505539 0.652573320711217 Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv1530 adh 15.2 4.3 6 6.6 3.6 14.3075321793256 0.0543323944828429 0.813943269781007 0.0667520655308829 0.946779084408245 0.976271183980787 Probable alcohol dehydrogenase Adh I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1531 - 40.2 14.9 16.4 26 7 20.9112436912479 0.214368213856312 0.667682709630023 0.321063000081428 0.748162648782912 0.866745856242036 hypothetical protein V - Conserved hypotheticals Rv1532c - 31.1 15.7 22.2 20 13.2 17.6327144915311 0.203761047734267 0.736183122430923 0.276780384561705 0.781948743834917 0.885336132396263 hypothetical protein V - Conserved hypotheticals Rv1533 - 111.9 78.2 53.9 54.9 25.2 138.627418081657 -0.196357939258218 0.344918788667867 -0.56928745463993 0.569161079119634 0.741219001419742 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1534 - 82.5 65.7 38.6 51.2 9.1 58.1234585616507 -0.346307606084671 0.466366443563579 -0.742565445829421 0.457744815157297 0.651660826080042 Probable transcriptional regulator I.J.1 - Repressors/activators Rv1535 - 324.2 163.5 147.6 159.6 72.7 77.166623686818 -0.0643246318358058 0.404347504119855 -0.159082549491239 0.873603836619757 0.935276396979876 hypothetical protein VI - Unknowns Rv1536 ileS 127 76.2 67.3 73.2 22.2 420.106443032967 -0.182516169625432 0.260216076442114 -0.701402358074651 0.483051950799565 0.670968631267474 Isoleucyl-tRNA synthetase IleS II.A.3 - Aminoacyl tRNA synthases and their modification Rv1537 dinX 17.3 7.8 12.4 9.6 5.7 28.7483400370857 0.0243684554916528 0.609986455320672 0.0399491747383837 0.968133646597873 0.986515931026946 Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1538c ansA 40 24.6 20.7 14.2 0 30.7501250253431 -1.30955567003553 0.672897066152997 -1.94614560815722 0.0516372513808015 0.143001676615167 Probable L-aparaginase AnsA I.A.2 - Amino acids and amines Rv1539 lspA 350.6 190.3 163.1 181.6 58.3 209.531292257842 -0.191751385272639 0.296949044992482 -0.645738346380248 0.518448822156973 0.701655105911572 Probable lipoprotein signal peptidase LspA III.D - Protein and peptide secretion Rv1540 - 278.8 155.3 125.5 130.2 37.3 238.999717601998 -0.398088772084441 0.291170306507499 -1.36720250378343 0.171561840781141 0.341005634145231 Conserved hypothetical protein member of yabO/yceC/yfiI family V - Conserved hypotheticals Rv1541c lprI 5.4 0.7 3.6 15.3 0 4.69032678279057 1.84467326015179 1.44357272380402 1.27785267048467 0.201301378904414 NA Possible lipoprotein LprI II.C.1 - Lipoproteins(lppA-lpr0) Rv1542c glbN 12.5 0 18 42.7 33.6 24.5320837443249 2.73665346776001 0.767922294348442 3.56371144307248 0.00036564790092872 0.00268141794014394 Hemoglobin GlbN I.B.6.a - aerobic Rv1543 - 234.1 155.2 160.2 109.8 61 288.797173304752 -0.255790637091188 0.323140892054686 -0.791576192863575 0.428607833028511 0.623393457326405 Possible fatty acyl-CoA reductase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1544 - 264.9 153.8 147.8 67.3 21.9 180.273384453731 -1.3563527570057 0.325449295151807 -4.16763157029737 3.07780867593736e-05 0.000335433794774466 Possible ketoacyl reductase I.I - Polyketide and non-ribosomal peptide synthesis Rv1545 - 177.3 59.5 56.5 61.4 20.4 28.0535616043191 -0.534418558386216 0.615493792072635 -0.868276114673059 0.385243194683243 0.586138915622014 Hypothetical protein VI - Unknowns Rv1546 - 136.4 88 45.8 52 13.7 48.9983390610534 -0.652491703090813 0.490138320529161 -1.33123992914158 0.183110076927821 0.355926293098279 hypothetical protein V - Conserved hypotheticals Rv1547 dnaE1 90.2 64.8 47.4 47.9 21.1 367.97961529592 -0.141432769218986 0.281700784881034 -0.502067359445643 0.615620139430612 0.774334706627567 Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1548c PPE21 13.4 8.3 6.9 9.8 3.9 32.6371391375613 0.282364725274824 0.541285126506966 0.521656168712757 0.601909747742826 0.764693086981739 PPE family protein PPE21 IV.C.2 - PPE family Rv1549 fadD11.1 16.9 1.9 5.6 29.1 14.9 16.4761136851632 2.23472693565854 0.799472473814328 2.79525188027617 0.00518592928367073 0.023762692784944 Possible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1550 fadD11 10.6 11 9.4 10.8 2.2 28.1964152541318 -0.0154300005845528 0.617013441623952 -0.025007559874128 0.980048933587922 0.993121291743379 Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1551 plsB1 5 2.9 1.6 3.2 1.1 8.33873866077411 0.11229479991795 1.00553349455493 0.111676836749883 0.911079646016891 0.957011893888442 Possible acyltransferase PlsB1 I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1552 frdA 6.9 4.5 4.2 12.7 5.2 25.1101178002906 1.56087764630578 0.606545960215327 2.57338725947769 0.0100708451738551 0.0398557917383181 Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1553 frdB 2.2 2.3 1.4 2.4 0 1.60537729283476 0.413944120971453 2.11550836175679 0.195671228937001 0.844867505053007 NA Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1554 frdC 2.4 0 4.9 1.1 0 0.858390279334987 -0.870280692069364 2.87075566356324 -0.303153870987806 0.761772601404234 NA Probable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1555 frdD 2.9 0.5 0.8 0.3 0 0.222180653504478 -0.451834289233534 4.45530996974715 -0.10141478197962 0.919221202649329 NA Probable fumarate reductase [membrane anchor subunit] FrdD (fumarate dehydrogenase) (fumaric hydrogenase) I.B.6.b - anaerobic Rv1556 - 11.8 10.6 1.8 3.7 3.9 7.4162824512012 -0.0782611590535021 1.17884969360764 -0.0663877332944787 0.947069136071078 0.976286053540092 Possible regulatory protein I.J.1 - Repressors/activators Rv1557 mmpL6 14.4 2.9 6.1 22.1 1.7 18.4227470519226 1.14220022750166 0.798033395087159 1.43126870947163 0.15235321811969 0.314289515771661 Probable conserved transmembrane transport protein MmpL6 II.C.4 - Conserved membrane proteins Rv1558 - 140.1 73.7 59.5 80.9 20.4 58.4759923279829 -0.114473820291922 0.442764759585521 -0.258543205649616 0.795987708746595 0.894413994739489 hypothetical protein V - Conserved hypotheticals Rv1559 ilvA 158.2 79 67.2 72.6 19 177.697557221993 -0.399942073360149 0.319840873201058 -1.25044078749978 0.211138572822844 0.391676575290697 Probable threonine dehydratase IlvA I.D.7 - Branched amino acid family Rv1560 vapB11 120.4 78 64.7 132.9 39.7 37.1803064741447 0.719934833317581 0.510781450232016 1.40947724900847 0.158694096148906 0.324534924110522 Possible antitoxin VapB11 V - Conserved hypotheticals Rv1561 vapC11 61.3 32.2 29.8 47.8 19.7 29.5029249172639 0.483004599230604 0.564949692157216 0.854951522119233 0.392577985902198 0.593207723022199 Possible toxin VapC11 V - Conserved hypotheticals Rv1562c treZ 26.9 19.3 16.8 2.7 1.1 37.9062717451488 -2.87709634626855 0.618882487974191 -4.64885725832419 3.33779093736306e-06 4.84526864759834e-05 Maltooligosyltrehalose trehalohydrolase TreZ II.A.8 - Polysaccharides (cytoplasmic) Rv1563c treY 36.8 23.7 10.2 3.6 1.3 53.5185049774497 -2.49925049507982 0.549101321417759 -4.55152883010162 5.32574981516039e-06 7.42669521468429e-05 Maltooligosyltrehalose synthase TreY II.A.8 - Polysaccharides (cytoplasmic) Rv1564c treX 93.3 75.3 38.4 24.3 6.9 173.195662147707 -1.40403046558297 0.353164084502959 -3.9755754539961 7.02092784472246e-05 0.000662246642192804 Probable maltooligosyltrehalose synthase TreX II.A.8 - Polysaccharides (cytoplasmic) Rv1565c - 140.6 95.5 54.2 58.7 28.3 306.815205864699 -0.266383350089196 0.30847854381555 -0.863539313931912 0.387841013788337 0.5888863169926 hypothetical protein II.C.5 - Other membrane proteins Rv1566c - 173.7 99 63.4 43.1 41.2 111.589575875178 -0.374341297392524 0.446005921277239 -0.839319120070228 0.401290256632693 0.599987373994512 Possible Inv protein IV.A - Virulence Rv1567c - 48.7 39.3 23.6 25.6 0 12.0824699170132 -0.806673360549674 0.927427606427095 -0.869796580303852 0.384411580642272 0.585376534236857 Probable hypothetical membrane protein VI - Unknowns Rv1568 bioA 26.8 9.6 8.1 5.5 1.7 20.4164535955284 -1.37477269358289 0.735472114311663 -1.86923836652809 0.0615896586712175 0.162216617313321 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA I.G.1 - Biotin Rv1569 bioF1 45.8 13.8 13.9 13.4 0.2 29.6161061735857 -1.12778559410056 0.710174673341229 -1.58803972661339 0.112277356190268 0.253788382658539 Probable 8-amino-7-oxononanoate synthase BioF1 (AONS) (8-amino-7-ketopelargonate synthase) (7-keto-8-amino-pelargonic acid synthetase) (7-KAP synthetase) (L-alanine--pimelyl CoA ligase) I.G.1 - Biotin Rv1570 bioD 49.9 29.1 21.3 9.5 1.1 22.9659527604179 -1.98328273330913 0.755814220882387 -2.62403468803976 0.00868949348180553 0.0355502510758623 Dethiobiotin synthetase BioD I.G.1 - Biotin Rv1571 - 28.8 12 9.8 1.8 0 7.30072556482365 -3.26292773536811 1.28529175923382 -2.53866696952387 0.0111275690941634 0.0434551816224111 hypothetical protein V - Conserved hypotheticals Rv1572c - 5.6 0 0 3.9 0 0.208854549197404 0.856351915824248 4.42645697911262 0.19346215717563 0.846597040357858 NA hypothetical protein V - Conserved hypotheticals Rv1573 - 25.1 18.2 3.3 1 0.8 5.50125742017091 -3.85524240983224 1.54586605322265 -2.49390456682535 0.012634650913085 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1574 - 49.7 28.2 22.6 27.7 8 15.0648925872765 -0.146252858627703 0.763285102708612 -0.191609738102717 0.8480479139553 0.91718647671135 Probable PhiRv1 phage related protein IV.B.3 - Phage-related functions Rv1575 - 20 8.4 4.5 7.1 1.6 5.70316839352981 -0.811162212297501 1.28926739172201 -0.629165227869503 0.529240890792753 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1576c - 90.7 39.8 30.6 97.3 32 164.598757923917 1.09111748739296 0.329557781484466 3.31085335772717 0.000930119367604999 0.00581037530874234 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1577c - 170.5 78 81.5 216 44.4 114.979592928408 0.929482058036319 0.366379069959655 2.53694092879998 0.011182582139566 0.0436187470450057 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1578c - 32.6 18.2 5.3 12.3 0 9.10386294416605 -0.779157866120571 1.09306615965666 -0.712818578488709 0.475958027725774 0.664764721689546 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1579c - 18 10.8 6.4 1.9 4 4.65829479097294 -1.51696745091888 1.46622562421451 -1.03460710675518 0.300852433717034 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1580c - 13.8 4.8 10.7 5.3 2.7 2.74211016268579 -1.11616413613811 1.73670505055005 -0.642690672077331 0.52042483486427 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1581c - 4.9 0 2.4 1 0 0.768146437409811 -0.791279006678447 2.98939381084606 -0.264695472308648 0.791244065702079 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1582c - 12.7 8.6 8.6 8.9 1.4 19.0818355168285 -0.351306471965641 0.727429663820544 -0.482942185943503 0.629136787009924 0.784372579932824 Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1583c - 15.3 14.1 1.5 8.5 0 4.57700211010499 -0.521910464143395 1.44698278995062 -0.36068878480663 0.718332109572671 NA Probable PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1584c - 56.2 30.3 7.6 23.6 3.4 7.27995656615507 -0.559976196407659 1.19357727000002 -0.469157892398244 0.638956780896092 0.792118010272337 Possible PhiRv1 phage protein IV.B.3 - Phage-related functions Rv1585c - 66.5 28.1 41.2 46.3 16.3 39.4460763452659 0.200624704082032 0.52002324963655 0.385799489200243 0.699645173630039 0.834110806125075 Possible phage PhiRv1 protein IV.B.3 - Phage-related functions Rv1586c - 65.5 40 36.1 55 20.2 120.899242500375 0.449656813777717 0.341602300492292 1.31631670257988 0.188067767108812 0.363016910680879 Probable PhiRv1 integrase IV.B.3 - Phage-related functions Rv1587c - 35.5 31.1 14.4 21.1 8.9 41.5981532531208 -0.0735165121055466 0.517703207382037 -0.142005131622249 0.887075952318509 0.942978839353035 Partial REP13E12 repeat protein IV.B.2 - REP13E12 family Rv1588c - 56.7 32 28.6 28.2 5.9 34.4270647216974 -0.462851340169445 0.550129328898912 -0.84135005326083 0.400151857648695 0.599442325641651 Partial REP13E12 repeat protein IV.B.2 - REP13E12 family Rv1589 bioB 92 36.3 49.1 26.1 9.1 77.1780578226072 -0.976792490982421 0.432228238844302 -2.25989975480127 0.0238274731463261 0.0794697833185376 Probable biotin synthetase BioB I.G.1 - Biotin Rv1590 - 177.4 71.4 65.5 66.1 3.3 27.5166884737843 -0.956877627520772 0.705302712300353 -1.35669069582889 0.174879510038237 0.344506798974102 hypothetical protein V - Conserved hypotheticals Rv1591 - 74.9 40.7 22.1 12.8 2.6 30.991682803399 -1.82079543641535 0.640338856489739 -2.84348734730347 0.00446227810922423 0.0208514367584066 Probable transmembrane protein V - Conserved hypotheticals Rv1592c - 82.9 36.3 42.2 130 49.9 199.727714236315 1.55182153298384 0.31222297669579 4.97023489240459 6.68718385429672e-07 1.13875025057303e-05 hypothetical protein V - Conserved hypotheticals Rv1593c - 377.4 226.9 139.2 309.6 78 296.100082063698 0.382893243123297 0.293023087248915 1.30669991473416 0.191314647661049 0.366838376137238 hypothetical protein V - Conserved hypotheticals Rv1594 nadA 1725 863.1 885.9 940 355.6 1884.68131438461 -0.0135889902271625 0.238782916539904 -0.0569093904374502 0.95461737395062 0.979789840200839 Probable quinolinate synthetase NadA I.G.7 - Pyridine nucleotide Rv1595 nadB 848 314.6 516.1 256.6 70 1096.56291119481 -1.07765609630254 0.307203933777047 -3.50795018492391 0.000451573599413254 0.00318620256797161 Probable L-aspartate oxidase NadB I.G.7 - Pyridine nucleotide Rv1596 nadC 859.7 326.1 378.1 217.3 65.8 530.637555824851 -1.0973872525168 0.289386955485234 -3.7921102928663 0.000149372543040597 0.00126271491038137 Probable nicotinate-nucleotide pyrophosphatase NadC I.G.7 - Pyridine nucleotide Rv1597 - 152 37.7 52.9 61.8 17.8 83.3059936933934 -0.214355295154427 0.449081925106934 -0.477318910360032 0.633135047144151 0.787693831044813 Hypothetical protein VI - Unknowns Rv1598c - 220.1 142.5 76.4 131 47.6 93.7079044166541 0.101323660384791 0.384636743391778 0.263426888162855 0.792221568489307 0.892509158902394 hypothetical protein V - Conserved hypotheticals Rv1599 hisD 226.1 112.2 110.4 118.1 25.7 272.77296035855 -0.367898875077111 0.303841400666546 -1.21082536570079 0.225962341436897 0.409681298300799 Probable histidinol dehydrogenase HisD (HDH) I.D.5 - Histidine Rv1600 hisC1 221.8 115.4 107.9 207.3 55.6 308.205704187862 0.548560343561199 0.277560964204418 1.9763598427234 0.0481140363158399 0.136598145413889 Probable histidinol-phosphate aminotransferase HisC1 I.D.5 - Histidine Rv1601 hisB 200.4 118.2 154 106.4 75.5 172.870450610162 0.111914871952003 0.392031259812333 0.285474357339711 0.775280747275066 0.881423631580758 Probable imidazole glycerol-phosphate dehydratase HisB I.D.5 - Histidine Rv1602 hisH 228.2 114.6 121.1 183.4 98.3 194.933735025513 0.757640360006326 0.332117254745936 2.28124359448264 0.0225340364056178 0.0763055037750461 Probable amidotransferase HisH I.D.5 - Histidine Rv1603 hisA 187.2 87.1 91.2 123.6 11.4 123.663493023486 -0.271199890578124 0.4243129610376 -0.639150616363311 0.522724954573417 0.704525033903745 Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA I.D.5 - Histidine Rv1604 impA 224.6 114.9 136.8 88.8 16.2 161.874335459097 -0.93239121698322 0.362180095556686 -2.57438558447033 0.0100418293279418 0.0397854132881094 Probable inositol-monophosphatase ImpA (imp) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1605 hisF 168.5 71.8 86.9 56.3 21.5 114.700858635794 -0.71448293517218 0.373566772893393 -1.91259765861478 0.0557995796573211 0.152501628970858 Probable cyclase HisF I.D.5 - Histidine Rv1606 hisI 151.2 98 86.9 66.3 21.8 52.5844078859936 -0.617072910409957 0.462705788642805 -1.33361830682935 0.182328980161015 0.355230609312604 Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI I.D.5 - Histidine Rv1607 chaA 39.8 36.8 15.8 13.6 2.7 38.6636741908439 -1.19081995047069 0.574715259914236 -2.07201728147674 0.0382638295848994 0.115051344982779 Probable ionic transporter integral membrane protein ChaA III.A.2 - Cations Rv1608c bcpB 103.4 75.4 40.7 56.9 9.8 44.1352607773401 -0.442125207340217 0.524427767476208 -0.843062161769065 0.399193679246945 0.598875057980804 Probable peroxidoxin BcpB III.F - Detoxification Rv1609 trpE 116 57 53.7 63.4 19.5 174.210958424593 -0.105183982714044 0.31439515758233 -0.334559805319201 0.737957169880515 0.860666544523143 Anthranilate synthase component I TrpE (glutamine amidotransferase) I.D.4 - Aromatic amino acid family Rv1610 - 109 47.8 61.5 55.3 8.7 67.9068154454069 -0.509338333682071 0.458776230570674 -1.11021081682567 0.266908192702978 0.460940428353949 Possible conserved membrane protein II.C.5 - Other membrane proteins Rv1611 trpC 399.6 317.1 201.5 123.7 24 294.027880354211 -1.39380146395646 0.323297103898593 -4.31120924731095 1.62364166919049e-05 0.000198308234216301 Probable indole-3-glycerol phosphate synthase TrpC I.D.4 - Aromatic amino acid family Rv1612 trpB 366.6 362 235.6 92.9 41.2 482.544050737895 -1.4980300750186 0.309908658948897 -4.83377934679012 1.33965070270045e-06 2.14707818505203e-05 Tryptophan synthase, beta subunit TrpB I.D.4 - Aromatic amino acid family Rv1613 trpA 300.1 267.9 230.7 18.3 12.8 230.261083780507 -3.50364830522671 0.410821543613606 -8.5283947730892 1.48392391742027e-17 1.81243397086297e-15 Probable tryptophan synthase, alpha subunit TrpA I.D.4 - Aromatic amino acid family Rv1614 lgt 450.1 396.8 245.8 51.6 20.4 548.765066399892 -2.58919332197923 0.301788885571133 -8.57948534810754 9.52985578385793e-18 1.20552675665803e-15 Possible prolipoprotein diacylglyceryl transferases Lgt III.D - Protein and peptide secretion Rv1615 - 232.8 194.1 102.2 162.9 65.6 128.955526842782 0.177526878853594 0.356674087775573 0.497728556511505 0.618675377640105 0.776623700814895 Probable membrane protein VI - Unknowns Rv1616 - 136.3 108.2 56.8 114.7 12.4 58.2526910242275 -0.0112212888439977 0.494816899195711 -0.0226776588718718 0.981907396890168 0.994053081912501 hypothetical protein V - Conserved hypotheticals Rv1617 pykA 89.2 57 67.4 69 29.2 178.393499323322 0.232756385342574 0.34076470098285 0.683041361594223 0.494580706821883 0.682964859088932 Probable pyruvate kinase PykA I.B.1 - Glycolysis Rv1618 tesB1 115.6 92.5 72.4 86.3 38.1 146.070134223407 0.208771419529221 0.343742499775549 0.607348290262453 0.543619797320622 0.722243556680286 Probable acyl-CoA thioesterase II TesB1 I.H.1 - Synthesis of fatty and mycolic acids Rv1619 - 29.6 16.8 13.1 16.9 11.7 52.8407566043821 0.42459831512087 0.486276852277412 0.873161683786349 0.382574956262899 0.583081108039238 hypothetical protein V - Conserved hypotheticals Rv1620c cydC 192.9 59.9 110.1 230.6 82.5 488.845039401261 1.17069497406777 0.328636483286937 3.56227939868022 0.000367648806391088 0.00268816525771253 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydC I.B.6.c - Electron transport Rv1621c cydD 128.2 42.9 62.2 293.3 56.7 371.175149369444 1.8057481781908 0.334247998646097 5.40242031517063 6.57476674723525e-08 1.36186104202966e-06 Probable 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein ABC transporter CydD I.B.6.c - Electron transport Rv1622c cydB 145.4 83.1 75 670.7 197.8 567.087004239159 2.83999020367909 0.251534841418619 11.2906434260239 1.4596420507369e-29 7.38578877672872e-27 Probable integral membrane cytochrome D ubiquinol oxidase (subunit II) CydB (cytochrome BD-I oxidase subunit II) I.B.6.c - Electron transport Rv1623c cydA 329.7 239 192.5 996.4 468.4 1607.54718352149 2.40297906062323 0.258719808364914 9.28795934029884 1.57274645942283e-20 2.6526990282265e-18 Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) CydA (cytochrome BD-I oxidase subunit I) I.B.6.c - Electron transport Rv1624c - 61.3 40 22.2 78.1 29.6 55.8027606800239 1.1999328111384 0.444610237089229 2.69884206669218 0.00695811886078224 0.0302400699446512 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv1625c cya 187.4 106.9 103.4 173.7 78 359.725088728474 0.767015932095451 0.281612060677041 2.72366151595717 0.00645626378948408 0.0284783142495051 Membrane-anchored adenylyl cyclase Cya (ATP pyrophosphate-lyase) (adenylate cyclase) IV.J - Cyclases Rv1626 - 789.5 555.5 331.5 625.9 300.2 656.995487277655 0.63545948710769 0.27781700816543 2.28733111519686 0.0221765036540895 0.0752423853786514 Probable two-component system transcriptional regulator I.J.2 - Two component systems Rv1627c - 178.8 79.1 100.5 123.4 32.7 229.688716340534 0.0953343788187016 0.316224339979511 0.3014770426112 0.763050753502075 0.875802258232129 Probable nonspecific lipid-transfer protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1628c - 282.3 86.9 152 201.7 73.3 151.976472494009 0.45257503114994 0.374135931079825 1.20965401490235 0.22641168218768 0.409785476907902 hypothetical protein V - Conserved hypotheticals Rv1629 polA 42.6 11.9 20.3 30.8 8.4 114.596909140321 0.403555129759278 0.40027815937071 1.00818673293022 0.313364825791047 0.511199083743142 Probable DNA polymerase I PolA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1630 rpsA 591.1 344.7 281.3 536 223.4 1169.1732879738 0.76560303472871 0.240433488521338 3.18426122516108 0.00145123983509365 0.00844054432824583 30S ribosomal protein S1 RpsA II.A.1 - Ribosomal protein synthesis and modification Rv1631 coaE 308.6 167.3 176.8 127.8 53.5 377.330205976845 -0.454135615773064 0.284206583670716 -1.5979067406096 0.110063733726698 0.249421461842588 Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase) V - Conserved hypotheticals Rv1632c - 118.3 67.8 59.6 6.8 6.7 37.5618260042142 -3.18322690694842 0.664909550821205 -4.78745853931101 1.68906617492575e-06 2.64720017326858e-05 Hypothetical protein VI - Unknowns Rv1633 uvrB 146.1 98.2 86.5 119.4 42 404.167588884113 0.30693030700106 0.26593097480617 1.15417283460407 0.24842931743562 0.439309357142768 Probable excinuclease ABC (subunit B-helicase) UvrB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1634 - 92.3 53.1 39.9 58.9 15.5 132.475930199479 0.014671887863375 0.33736870942098 0.0434891780229297 0.965311591052389 0.98505723293217 Possible drug efflux membrane protein III.A.6 - Efflux proteins Rv1635c - 66.7 21.8 36.4 43.3 17.2 120.326543675346 0.343137221392926 0.387756101343364 0.884930553520995 0.376194087973201 0.576830934892241 Probable mannosyltransferase Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1636 TB15.3 235.1 143.5 95.7 255.2 68.7 135.44098951492 0.779947927923721 0.333938052846115 2.3356066230737 0.0195117530899586 0.0684263657867659 Iron-regulated universal stress protein family protein TB15.3 V - Conserved hypotheticals Rv1637c - 50.3 26 19.7 49.9 16.4 51.0323252631437 0.846100719736678 0.454382483160304 1.86208921138841 0.0625905164698799 0.164340703733369 hypothetical protein V - Conserved hypotheticals Rv1638 uvrA 80.4 41.5 38.4 111.9 25.9 341.114755988476 1.05602494798332 0.280789054916655 3.76091920070309 0.00016929011138674 0.0014009943330183 Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1638A - 174.8 87.8 118.5 170.2 86.5 69.6338942228424 0.812920503130467 0.435089638314232 1.86839775426542 0.061706649876069 0.162278954631295 hypothetical protein ? Rv1639c - 245 167.3 126.8 232.3 57.6 460.309158902215 0.372625015452581 0.264949814675724 1.40639847553259 0.159605832717246 0.325272646423755 hypothetical protein V - Conserved hypotheticals Rv1640c lysX 12.8 6.9 6.9 9.5 3.2 52.2004109574428 0.263898836844741 0.451808359637323 0.584094630423791 0.559156647224486 0.732987729263186 Lysyl-tRNA synthetase 2 LysX II.A.3 - Aminoacyl tRNA synthases and their modification Rv1641 infC 747 580.4 466.3 2566.3 1479.3 1871.89906999427 2.70001593572517 0.288762100551902 9.35031269880886 8.73889780518743e-21 1.54765880129869e-18 Probable initiation factor if-3 InfC II.A.6 - Protein translation and modification Rv1642 rpmI 891.3 548.6 690.6 1608.4 945.9 445.891844534985 1.75137344882973 0.330958365218147 5.29182408692202 1.21102351841946e-07 2.35683807815479e-06 50S ribosomal protein L35 RpmI II.A.1 - Ribosomal protein synthesis and modification Rv1643 rplT 681.9 348.8 425.5 946.3 460 504.161318260875 1.40856557362959 0.294741472790031 4.77898668380827 1.76180860966142e-06 2.74904233278446e-05 50S ribosomal protein L20 RplT II.A.1 - Ribosomal protein synthesis and modification Rv1644 tsnR 422.5 212.7 242.4 204.4 38.1 304.105905142479 -0.633680168611258 0.319740290385141 -1.98185898889365 0.0474950250948022 0.135122392679349 Possible 23S rRNA methyltransferase TsnR II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv1645c - 30.1 21.2 6.9 55.2 5.6 44.6509283298101 1.30952968295407 0.56432181305299 2.32053706354091 0.0203118423349809 0.0703270239985362 hypothetical protein V - Conserved hypotheticals Rv1646 PE17 201.3 104.9 68.3 285 39.9 236.977053635229 0.993479746914812 0.358537991130618 2.77091904202944 0.00558983230170345 0.0252540637916245 PE family protein PE17 IV.C.1.a - PE subfamily Rv1647 - 22.4 14.4 9.6 27.7 7.5 30.352548070746 0.952233361711519 0.555448903745405 1.71434916027485 0.0864646195785008 0.20988176752288 Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase) V - Conserved hypotheticals Rv1648 - 31.5 22.5 4.9 22 2.4 20.984195951747 -0.00942913941420512 0.766698371095647 -0.0122983689149234 0.990187568675188 0.996155108273772 Probable transmembrane protein II.C.5 - Other membrane proteins Rv1649 pheS 34.7 18.1 18.1 18.5 11.1 40.6515453907013 0.116286302577981 0.519091111519607 0.224019059462529 0.822742472788198 0.906045859973057 Probable phenylalanyl-tRNA synthetase, alpha chain PheS II.A.3 - Aminoacyl tRNA synthases and their modification Rv1650 pheT 41.2 20.2 20 13.8 4.5 85.906435753134 -0.807834027705819 0.39453211658958 -2.04757482024254 0.0406016786749664 0.120042692710126 Probable phenylalanyl-tRNA synthetase, beta chain PheT II.A.3 - Aminoacyl tRNA synthases and their modification Rv1651c PE_PGRS30 16.5 10.9 8.5 15.6 7.7 75.3090617267451 0.769620863192514 0.405690754284198 1.89706286146559 0.0578196420564214 0.156453149093846 PE-PGRS family protein PE_PGRS30 IV.C.1.b - PE_PGRS subfamily Rv1652 argC 21.2 17.9 9.2 83.1 11.8 59.4530119758666 2.18102758399734 0.482411618829198 4.52109256673927 6.15212768447782e-06 8.41345029282642e-05 Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC I.D.1 - Glutamate family Rv1653 argJ 32.6 9.2 20.4 127.7 40.8 130.335002209477 2.75522916730033 0.3882399429541 7.09671742257099 1.27754895748368e-12 7.18266413874159e-11 Probable glutamate N-acetyltransferase ArgJ I.D.1 - Glutamate family Rv1654 argB 37.2 10 12.8 133.7 42.7 97.5581170373619 2.93554320518717 0.416654961817748 7.04550161212584 1.84794571668051e-12 1.00698826592037e-10 Probable acetylglutamate kinase ArgB I.D.1 - Glutamate family Rv1655 argD 26.2 13 17.8 72.2 27.1 87.0886059211143 2.14573768796299 0.394892579011174 5.4337250229822 5.51896081669072e-08 1.17054845585141e-06 Probable acetylornithine aminotransferase ArgD I.D.1 - Glutamate family Rv1656 argF 21.7 14.5 7.6 69.9 24.2 58.051656997994 2.46648608968231 0.447249232401222 5.51479110749966 3.49194464863122e-08 7.73029246590737e-07 Probable ornithine carbamoyltransferase, anabolic ArgF I.D.1 - Glutamate family Rv1657 argR 19.8 17.7 15.7 34.3 4.5 16.0605732103366 0.689818091675921 0.784819420576559 0.878951353126753 0.379427652959431 0.579531154283012 Probable arginine repressor ArgR (AHRC) I.J.1 - Repressors/activators Rv1658 argG 86.8 62.9 55.2 169.1 56 221.66389450538 1.46101245603043 0.298471248957284 4.89498556773729 9.8312943199725e-07 1.61964858052756e-05 Probable argininosuccinate synthase ArgG I.D.1 - Glutamate family Rv1659 argH 40.7 16 20.6 54.5 22.3 93.595217208089 1.38648800155762 0.387647060944529 3.57667616047274 0.000347990837107197 0.00257324330904738 Probable argininosuccinate lyase ArgH I.D.1 - Glutamate family Rv1660 pks10 32 18.9 18.2 42.1 7.1 46.3476194923806 0.741706983174557 0.492150046650887 1.50707490169293 0.131791459239079 0.283944859260838 Chalcone synthase Pks10 I.I - Polyketide and non-ribosomal peptide synthesis Rv1661 pks7 19 15.9 14.6 5.8 4.2 145.769865437166 -0.912091251739306 0.406170381374084 -2.2455877965638 0.024730422867408 0.0817881958882906 Probable polyketide synthase Pks7 I.I - Polyketide and non-ribosomal peptide synthesis Rv1662 pks8 17.4 14.1 16.2 5.4 1.6 93.5636139761192 -1.55213757691078 0.439583422597379 -3.5309283679071 0.000414103877282694 0.00295869392487625 Probable polyketide synthase Pks8 I.I - Polyketide and non-ribosomal peptide synthesis Rv1663 pks17 24.7 18.7 21.5 3.3 2.8 38.0956898145587 -2.3319263865329 0.635597468130744 -3.66887299502775 0.000243622061358501 0.00192613692261565 Probable polyketide synthase Pks17 I.I - Polyketide and non-ribosomal peptide synthesis Rv1664 pks9 30.1 26.3 22 20.7 7.1 123.803819480822 -0.198662649620245 0.364957916904087 -0.544343992604647 0.586204779071522 0.754483040505571 Probable polyketide synthase Pks9 I.I - Polyketide and non-ribosomal peptide synthesis Rv1665 pks11 42.4 17.7 12.7 43.3 14.1 53.9350433496289 1.03012840707153 0.461841866989067 2.23047861335602 0.0257156857212513 0.0843379248376593 Chalcone synthase Pks11 I.I - Polyketide and non-ribosomal peptide synthesis Rv1666c cyp139 24.8 10.3 12.1 8.2 1.4 23.2477056235103 -1.01365466424388 0.686379535535191 -1.47681364575287 0.139725597701716 0.296174785792626 Probable cytochrome P450 139 Cyp139 IV.F - Cytochrome P450 enzymes Rv1667c - 20.3 11.2 11.4 9.4 3.1 12.0505181156701 -0.581785834768663 0.86229271349145 -0.674696452452896 0.499868638888763 0.686356542085852 Probable second part of macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1668c - 29 26.9 19.9 7.6 7 38.2761488625299 -1.11344665354013 0.597516516355661 -1.86345753307573 0.0623979220080865 0.163956557680002 Probable first part of macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1669 - 4.7 9 0 2.7 0 1.72411455974994 -0.899010457526589 2.22393109571338 -0.404243845171025 0.686033414787072 NA Hypothetical protein VI - Unknowns Rv1670 - 19.1 2.5 0.5 18 16.2 8.71207322235337 2.37625932108248 1.23321973078491 1.92687423154513 0.0539953055748826 0.148602464915489 hypothetical protein V - Conserved hypotheticals Rv1671 - 5.9 2.2 2.3 13.3 0 2.57531045064345 1.88242958704673 1.85771116461983 1.01330584802291 0.310914095079381 NA Probable membrane protein II.C.5 - Other membrane proteins Rv1672c - 24.1 15 10.7 14 7.3 37.1561363596706 0.178292809640748 0.528499853273186 0.337356403292296 0.735848245377797 0.858772482744039 Probable conserved integral membrane transport protein II.C.5 - Other membrane proteins Rv1673c - 4.3 3.7 4.1 2.3 3.2 6.66834627177298 0.1283171976781 1.17728779577901 0.108993907979139 0.913207322277252 NA hypothetical protein V - Conserved hypotheticals Rv1674c - 3.7 0 0.7 1.5 0 0.835418196789614 0.581502924407969 3.12594913764179 0.186024435716396 0.852425598848105 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1675c cmr 2.4 3.2 0 1.7 0 1.54556378749493 -0.0626014570721761 2.28402113127984 -0.0274084404101365 0.978133966305139 NA Probable transcriptional regulatory protein Cmr I.J.1 - Repressors/activators Rv1676 - 297.4 218.1 184 168 69.5 252.656494856986 -0.194322681439366 0.301100657800356 -0.645374483267357 0.518684535126783 0.701655105911572 hypothetical protein IV.F - Cytochrome P450 enzymes Rv1677 dsbF 240.1 124.1 100.5 143.3 25 118.773886917975 -0.190019593287199 0.375894903541541 -0.505512555495979 0.61319888218268 0.771837398966258 Probable conserved lipoprotein DsbF II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1678 - 139.9 105.9 90.7 33.1 29.6 136.991169694688 -0.952339023043312 0.423673642949919 -2.24781276553445 0.0245881315261755 0.0813936092202932 Probable integral membrane protein II.C.5 - Other membrane proteins Rv1679 fadE16 96.1 66.2 43.2 26.6 8.7 92.0202297664622 -1.19752280690394 0.391835380242697 -3.05618856102839 0.00224170229900972 0.0121223046459426 Possible acyl-CoA dehydrogenase FadE16 I.A.3 - Fatty acids Rv1680 - 62.1 51.8 34.6 7.5 4.8 45.0205720343866 -2.38863160195421 0.570682712947938 -4.18556852653801 2.84453234111374e-05 0.000314875620260714 Hypothetical protein VI - Unknowns Rv1681 moeX 46.1 29.8 19.9 4.9 3.6 34.5418326152689 -2.19038963430997 0.628407396100789 -3.48562039196409 0.00049099722565033 0.00343020152515477 Possible molybdopterin biosynthesis protein MoeX I.G.4 - Molybdopterin Rv1682 - 86.1 45.8 47.6 135.2 35.3 129.452636485895 1.22430142363756 0.339361830217125 3.60765800577586 0.000308973380056313 0.002328475983318 Probable coiled-coil structural protein V - Conserved hypotheticals Rv1683 - 91.8 57.6 43.5 55.6 14.6 285.855739584797 -0.146188891867414 0.281470749181932 -0.519375076423742 0.603499208218218 0.76520577719971 Possible bifunctional enzyme; long-chain acyl-CoA synthase and lipase I.A.3 - Fatty acids Rv1684 - 45 14.9 28.6 24.3 14.9 10.6360109128411 -0.0120332497623156 0.91893775897187 -0.0130947386205772 0.989552208812 0.996155108273772 hypothetical protein V - Conserved hypotheticals Rv1685c - 8 0.3 3.5 11.5 0.5 4.40194778879476 1.16138579173108 1.48675026911719 0.781157276951891 0.434709997819946 NA hypothetical protein V - Conserved hypotheticals Rv1686c - 13.8 10.2 8 22 5.7 15.658417816575 1.14252857102386 0.739780035835905 1.54441660450173 0.122487440044654 0.26963984626362 Probable conserved integral membrane protein ABC transporter II.C.5 - Other membrane proteins Rv1687c - 8 10.3 4.8 15.1 6 13.2574763869118 1.2354055922392 0.816440078454868 1.51316137563609 0.130238672597244 0.281541174292748 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1688 mpg 4 0 0 3.5 0 1.201788347292 1.1347090762539 2.71429903133926 0.418048661239078 0.675911539516922 NA Possible 3-methyladenine DNA glycosylase Mpg II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1689 tyrS 35 30.6 20.7 14 1.2 42.6592872194239 -1.26279474895499 0.573830812466197 -2.20063949429236 0.0277615553321927 0.0895550355069458 Probable tyrosyl-tRNA synthase TyrS (TYRRS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv1690 lprJ 51.3 39.3 20.3 120.9 21.1 36.8100473557869 1.61048448816189 0.543575462367121 2.96276156607341 0.00304892641785289 0.0154863838529711 Probable lipoprotein LprJ II.C.1 - Lipoproteins(lppA-lpr0) Rv1691 - 28 18.9 11.6 32 8.7 27.9542972199486 0.822787672231925 0.577954392113339 1.42362041617736 0.154556382563703 0.317908656818022 hypothetical protein VI - Unknowns Rv1692 - 37.3 17.6 16.3 22.7 5.7 37.5645358987238 0.0196557235693439 0.520082367392688 0.0377934819591815 0.969852341304284 0.987415059758486 Probable phosphatase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1693 - 211.8 134.4 76.2 116.8 38.4 36.3313032181219 -0.123503589545391 0.530445419025853 -0.232829967260726 0.815893441813314 0.903402026238493 hypothetical protein VI - Unknowns Rv1694 tlyA 78.3 64.7 32.1 32.8 5.7 56.9183723712082 -0.921526956902472 0.497454598710017 -1.85248454691573 0.0639562745572978 0.167059826314122 2'-O-methyltransferase TlyA IV.A - Virulence Rv1695 ppnK 66.7 41.4 40.1 27 5.2 57.3810968769956 -0.901098602460506 0.466750497507885 -1.93057877232425 0.0535351650982494 0.147565412278599 Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase) V - Conserved hypotheticals Rv1696 recN 47 27.9 25.5 8.9 1.6 63.3110926004469 -1.93257136790017 0.480780482871165 -4.01965436774613 5.82835831063813e-05 0.000568706477583478 Probable DNA repair protein RecN (recombination protein N) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv1697 - 234.8 178.5 104.1 65.3 38.5 266.654843944481 -0.837853788913205 0.335989251555658 -2.49369223876619 0.01264221057106 0.048228779389114 hypothetical protein V - Conserved hypotheticals Rv1698 mctB 150.6 103.5 64.7 63.4 26.9 141.116855532593 -0.430156833291689 0.342761065286206 -1.25497577425402 0.209487554472652 0.390056125636197 Outer membrane protein MctB V - Conserved hypotheticals Rv1699 pyrG 142.9 89.9 84.9 135.5 56.1 368.702528202094 0.66055464468472 0.276686253212599 2.3873778946913 0.0169690386756865 0.0613309540706955 Probable CTP synthase PyrG I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv1700 - 143.3 75.6 73.4 83.9 31.1 95.4516089099182 0.0140341677643218 0.370460964551057 0.0378829866227042 0.969780978020001 0.987415059758486 NUDIX hydrolase V - Conserved hypotheticals Rv1701 - 75.4 54.6 43.8 24.8 13.4 72.5927845059166 -0.856499357672236 0.433510795938465 -1.97572786121297 0.0481856076176792 0.136598145413889 Probable integrase/recombinase IV.B.3 - Phage-related functions Rv1702c - 20.3 17.4 13.8 0.9 0 22.9507461356818 -4.23903212277326 0.913442908451444 -4.64071928694446 3.47198511814031e-06 4.99909401969633e-05 hypothetical protein IV.B.2 - REP13E12 family Rv1703c - 150.8 98.4 70.6 139.2 45 115.678398214247 0.555612037022155 0.343001761340649 1.61985184813776 0.105264105547856 0.241950332154774 Probable catechol-O-methyltransferase IV.H - Miscellaneous transferases Rv1704c cycA 29.1 15.8 15.5 21.6 5.9 54.2243490178452 0.178301800081479 0.448074677387596 0.397928758485147 0.69068270062667 0.829287500210056 Probable D-serine/alanine/glycine transporter protein CycA III.A.1 - Amino acids Rv1705c PPE22 12.5 5.9 6.9 12.5 7.3 22.8694646878753 1.09973223914 0.650646108858167 1.6902156551277 0.0909867044036644 0.218491462371376 PPE family protein PPE22 IV.C.2 - PPE family Rv1706c PPE23 22.7 5.8 7.5 23.4 5.3 27.8760791952137 1.03036214830452 0.621764546450971 1.65715809012562 0.0974875172239822 0.228827558652979 PPE family protein PPE23 IV.C.2 - PPE family Rv1706A - 0 0 0 2.1 0 0.0854208528060269 2.09694716487919 4.43926588087807 0.472363499089273 0.636667353215063 NA hypothetical protein ? Rv1707 - 59.6 40 26.3 42.5 9.4 92.4895459943936 0.0172354322511563 0.384989041474611 0.0447686307774892 0.964291729025705 0.984867734777695 Probable conserved transmembrane protein III.A.4 - Anions Rv1708 - 74.1 74.5 37.8 40.4 17.3 88.3965278993799 -0.308656075419282 0.414906062718648 -0.743917968797156 0.456926103882592 0.650871212827001 Putative initiation inhibitor protein III.C - Cell division Rv1709 scpA 84.4 81.7 44.2 40.3 14.1 80.9842221839442 -0.603787758603011 0.420950600751881 -1.4343435014098 0.151474262057933 0.31302324166231 Possible segregation and condensation protein ScpA V - Conserved hypotheticals Rv1710 scpB 96.5 42.6 35.9 47.5 13.4 56.4282740062732 -0.178641830381081 0.45585854826962 -0.391879961578394 0.695146909558444 0.83088222249864 Possible segregation and condensation protein ScpB V - Conserved hypotheticals Rv1711 - 101.6 80.1 40.7 39.9 10.4 70.9659927304704 -0.836106774899146 0.439394668730681 -1.90286053609727 0.0570587456162628 0.15506744486081 hypothetical protein V - Conserved hypotheticals Rv1712 cmk 141.3 80.7 70.2 26.2 7.2 74.3289489125573 -1.79056017628389 0.43344567464134 -4.13099098927567 3.612027416786e-05 0.000385355455128193 Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv1713 engA 115.7 83.4 49.3 13.7 6.3 122.766546523739 -2.30367103285947 0.39625916419361 -5.81354638837806 6.1163012460767e-09 1.61671186668684e-07 Probable GTP-binding protein EngA V - Conserved hypotheticals Rv1714 - 28.8 19.3 11.4 2.7 2.4 16.7120645328787 -2.52210355887133 0.858558074572439 -2.9376039123822 0.00330759306032619 0.0164543463759485 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1715 fadB3 13.1 23.2 8.2 0.7 0 13.3849622511245 -4.51080912281213 1.20825971213661 -3.73331087472535 0.000188979107028902 0.00153172539381321 Probable 3-hydroxybutyryl-CoA dehydrogenase FadB3 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD) I.A.3 - Fatty acids Rv1716 - 27 21.2 12.1 1 0 15.7455897514231 -4.34188959545868 1.06577544758111 -4.073925333252 4.62273077389795e-05 0.000472675320890956 hypothetical protein V - Conserved hypotheticals Rv1717 - 15.3 3 1.8 0 0 1.79740698009738 -3.21156981073007 2.29199749648511 -1.40120999942416 0.161151284990306 NA hypothetical protein V - Conserved hypotheticals Rv1718 - 23.3 20.3 12.4 3.2 0 15.25354106485 -2.71286126980079 0.93281487774153 -2.90825257458264 0.00363454658943819 0.0177321818454408 hypothetical protein V - Conserved hypotheticals Rv1719 - 9.2 15.9 6.4 1.3 0 8.37537614528085 -3.02433468989862 1.24007337050158 -2.43883528333113 0.0147346828005438 0.0545923080329771 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1720c vapC12 57.4 15.5 21.2 20.9 0 12.9560514614058 -0.794440650502704 0.933899259406872 -0.850670607670532 0.394952354921062 0.594614104267602 Possible toxin VapC12 V - Conserved hypotheticals Rv1721c vapB12 47.3 23.5 17.3 32.1 0 8.39458084616761 -0.201891448555104 1.06072876406909 -0.190332774403724 0.84904837278192 0.917988197922332 Possible antitoxin VapB12 VI - Unknowns Rv1722 - 17.4 11 9.4 9.1 3.7 27.0757521416434 -0.244675444228881 0.593315685658917 -0.412386609932877 0.680056075961803 0.821541139514566 Possible carboxylase I.H.1 - Synthesis of fatty and mycolic acids Rv1723 - 9.8 6.8 5.3 4.4 0 10.3660644239062 -0.995521329548029 0.988574850062705 -1.0070267612866 0.313921914120716 0.511458794763375 Probable hydrolase II.B.6 - Aromatic hydrocarbons Rv1724c - 27.6 39 14.7 41.6 30.1 29.6825886872287 1.34002035762988 0.631714982500931 2.12124200747115 0.0339014418562072 0.103695083812337 Hypothetical protein VI - Unknowns Rv1725c - 22.8 13.4 8.3 10.3 7.3 17.169216345429 0.0569234150930366 0.74468636311674 0.0764394487563794 0.939069485827819 0.973096145501906 hypothetical protein V - Conserved hypotheticals Rv1726 - 1 0 0.8 1.7 0 1.32807956346665 1.35990660327216 2.41963401042145 0.56202987617755 0.574095663843106 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1727 - 1.2 0 1.3 0.8 0 0.496592305348782 -0.0217013119679595 3.54654769466031 -0.00611899622853882 0.995117777848444 NA hypothetical protein V - Conserved hypotheticals Rv1728c - 65.8 45.7 28.5 48.3 23.6 65.7825645921308 0.451844333587225 0.428662348197343 1.05407982643535 0.291846371442414 0.487786456500464 hypothetical protein V - Conserved hypotheticals Rv1729c - 23 16.7 6 29.2 8.4 29.8754444499933 1.08762839428089 0.58945881583704 1.84513042312625 0.0650185685924499 0.169210705330241 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv1730c - 39.9 32.6 16.6 33.1 12.4 81.8109279783532 0.408636744597603 0.401216479739087 1.01849441693756 0.308443052733782 0.504621382347832 Possible penicillin-binding protein II.C.3 - Murein sacculus and peptidoglycan Rv1731 gabD2 66.6 32.9 29.5 49.9 14.3 111.392133169697 0.325175215791745 0.352640831545247 0.922114476553524 0.356468866595691 0.556462197215486 Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 I.A.1 - Carbon compounds Rv1732c - 183.9 91.4 132 146.6 138.4 182.720746463452 1.13122015815566 0.425110252603485 2.6610041776875 0.00779079904693611 0.0332464854021531 hypothetical protein V - Conserved hypotheticals Rv1733c - 522.7 182.8 425.8 516.8 347.6 587.891296945399 1.16825499762619 0.397274062333171 2.94067775470938 0.00327495037279656 0.0163378510147119 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv1734c - 41.9 21.1 27.8 22 21.7 13.8834523759963 0.274529115984704 0.839974109989226 0.326830449557814 0.743796127628631 0.863495864982173 hypothetical protein VI - Unknowns Rv1735c - 87.9 40.1 65.1 66 12.7 48.8081945785371 -0.0716079661302268 0.510237766187316 -0.140342347971041 0.888389506551632 0.943105027107524 Hypothetical membrane protein VI - Unknowns Rv1736c narX 1443.1 775.2 986.5 1140 439.3 3740.75032947701 0.349290137785885 0.263214201715241 1.3270185860403 0.184502534568448 0.357890458620725 Probable nitrate reductase NarX I.B.6.b - anaerobic Rv1737c narK2 1025.4 460.2 631 814.2 199.3 1391.17529734501 0.177572155573933 0.280196602735112 0.633741286798551 0.526249675831306 0.707123046963007 Possible nitrate/nitrite transporter NarK2 III.A.4 - Anions Rv1738 - 16936.9 8529.8 11592.9 25691.1 11395.5 9499.57262480356 1.4301978054062 0.277474468984006 5.15434018359593 2.54525522695416e-07 4.74489158624824e-06 hypothetical protein V - Conserved hypotheticals Rv1739c - 11.5 4.1 2.5 23.2 12.5 43.6701726288881 2.50450863193606 0.553682354645507 4.5233672536658 6.08634976928996e-06 8.35575615613374e-05 Probable sulphate-transport transmembrane protein ABC transporter III.A.4 - Anions Rv1740 vapB34 103.1 57.2 43.4 229 26.8 35.0265246486089 1.52521724853406 0.576448614015858 2.64588588028438 0.00814772985635386 0.0341934350132765 Possible antitoxin VapB34 V - Conserved hypotheticals Rv1741 vapC34 122.1 57.8 29.4 152.9 30 35.5644748792432 1.15566473286956 0.560945551698172 2.06020839165401 0.0393786230294843 0.117505545720668 Possible toxin VapC34 Contains PIN domain V - Conserved hypotheticals Rv1742 - 33.1 17.1 6.2 40.5 4.6 24.7427515498038 0.905299986031416 0.692394950487623 1.30749073977772 0.191046097872766 0.366568406644279 hypothetical protein VI - Unknowns Rv1743 pknE 89.7 69.6 39.6 79.6 17.2 183.657298816197 0.224864274257022 0.333810926558188 0.673627662747658 0.50054806164658 0.686356542085852 Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1744c - 3.2 4.3 2.5 3.6 0 1.4458962221939 0.386738846539829 2.20291888476867 0.175557461154744 0.860641624285354 NA Probable membrane protein VI - Unknowns Rv1745c idi 3.6 0 2.2 3.5 0 1.7278903810382 0.40964313863323 2.16612594899033 0.189113259468671 0.85000404944804 NA Probable isopentenyl-diphosphate delta-isomerase Idi (IPP isomerase) (isopentenyl pyrophosphate isomerase) V - Conserved hypotheticals Rv1746 pknF 41.9 39.9 24.9 16.6 4.1 63.9485730081338 -1.06438092819591 0.460329014549874 -2.31221777153608 0.0207656854156845 0.0716183619691864 Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv1747 - 174.1 118.8 84.3 84.6 31.1 471.258801310906 -0.327443051861468 0.260549262103517 -1.25674142854174 0.208847281304256 0.38933530019983 Probable conserved transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv1748 - 17 10.6 13.6 12.6 5.4 16.6384160806705 0.093760756561346 0.742631751784059 0.126254710138774 0.899530305373853 0.950234518829164 hypothetical protein VI - Unknowns Rv1749c - 56.9 26.1 20.2 42.4 10.6 31.6290392482452 0.401083477722262 0.557859223587707 0.71896898135485 0.47216003190016 0.662333003164501 Possible integral membrane protein II.C.5 - Other membrane proteins Rv1750c fadD1 20.7 20.7 11.6 14.2 4.9 42.7744898754769 -0.174343040031895 0.512257723132815 -0.340342433425241 0.733598665124304 0.85727696201593 Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv1751 - 125.8 105.4 67.2 39.7 9.3 163.288214468913 -1.33752396627391 0.354647702519942 -3.77141584950405 0.000162323899550393 0.00135601710426296 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1752 - 54.5 53.3 29.7 15.1 4.1 23.2155675502409 -1.61550716765768 0.701442966140846 -2.30311977685908 0.0212721048675894 0.0730094917063969 hypothetical protein VI - Unknowns Rv1753c PPE24 8.4 5.5 9.3 8.4 12.8 77.7768346265901 1.59067964179286 0.573595516227063 2.77317307543802 0.00555125874805964 0.0251323722308361 PPE family protein PPE24 IV.C.2 - PPE family Rv1754c - 15.3 12.4 7.5 11.8 2.5 29.2992629471888 -0.0200342910023692 0.58721151400153 -0.0341176739976474 0.972783314877212 0.989545807379404 hypothetical protein V - Conserved hypotheticals Rv1756c - 4.8 4.4 2.3 3.3 0 4.48215753392311 -0.441796043100293 1.39605280732769 -0.316460839290152 0.75165274464766 NA Putative transposase IV.B.1.a - IS6110 Rv1757c - 9.3 16.4 7.9 3.9 12.1 7.96736241810323 0.365207270773689 1.18862568505377 0.307251707047847 0.758651791085055 0.874152454138993 Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1758 cut1 0 0 0 0 0 0 NA NA NA NA NA Probable cutinase Cut1 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1759c wag22 4.8 4.1 4.8 0.9 0.7 14.3709751882938 -2.2254566905967 0.918856032251659 -2.42198626605652 0.0154359339060566 0.0565621135244576 PE-PGRS family protein Wag22 IV.C.1.b - PE_PGRS subfamily Rv1760 - 7.9 6 2 13 6.7 23.883489397873 1.83149469468158 0.654292481572154 2.79919874714258 0.00512295945549243 0.0235045626831013 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv1761c - 9.2 6.7 5.8 8.3 1.6 3.46244496757142 0.0186246338897123 1.53860323331602 0.0121048971472472 0.990341925320603 NA Possible exported protein VI - Unknowns Rv1762c - 25.1 15.3 17.5 17.7 4.8 23.1495278560903 -0.055246242461206 0.64043570202432 -0.0862635269810553 0.931256931614729 0.968441588895881 hypothetical protein VI - Unknowns Rv1763 - 12.6 10.4 7.8 9.8 0 4.27238237653778 -0.354984121738511 1.41612582201245 -0.250672727112656 0.802067148167192 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv1764 - 5.3 2.2 1.6 2.5 0 3.20332488937006 -0.551255689246065 1.61922724431655 -0.340443684591499 0.733522425666 NA Putative transposase IV.B.1.a - IS6110 Rv1765c - 52.9 38.2 22 24.2 4.5 52.4958156046136 -0.653561260224455 0.482912389836253 -1.35337438835659 0.17593605529353 0.346203059916491 hypothetical protein V - Conserved hypotheticals Rv1765A - 2.8 0 0 21.5 0 1.74642989970589 3.50071648522988 2.35306119659004 1.48772861934189 0.13682247687651 NA Putative transposase (fragment) ? Rv1766 - 78.3 29.2 41.9 111.1 64.2 40.5667276158222 1.67889393629647 0.531723572603955 3.15745628517952 0.00159152097388466 0.00910689384410255 hypothetical protein V - Conserved hypotheticals Rv1767 - 38.3 43.9 9.9 32.9 10.4 17.989542508525 0.311750928260194 0.758416281017885 0.411055163322426 0.681032085978065 0.821853087261539 hypothetical protein V - Conserved hypotheticals Rv1768 PE_PGRS31 25.2 19 13.1 11.5 4 48.6229058252146 -0.552031118557566 0.47740720942788 -1.15631081319261 0.247554046961337 0.438199117609722 PE-PGRS family protein PE_PGRS31 IV.C.1.b - PE_PGRS subfamily Rv1769 - 90.2 80.8 60.1 56.2 14.2 136.2694517515 -0.478925729118594 0.362238942742722 -1.32212656511298 0.186126009126517 0.360053699795807 hypothetical protein VI - Unknowns Rv1770 - 114.2 83.3 55 84.1 38.8 193.839824013436 0.390777291987072 0.318518213732488 1.22686011392514 0.219875172100822 0.402895943911593 hypothetical protein V - Conserved hypotheticals Rv1771 - 102.7 74.6 57.6 104.1 56.8 221.5029284592 0.92308104346265 0.324004383550733 2.84897702107204 0.00438600481622827 0.0206585492806922 L-gulono-1,4-lactone dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1772 - 264.9 180.3 103.4 587.8 125.5 158.989450613053 1.65961196951935 0.338393566507138 4.90438392978238 9.37210202036753e-07 1.55121426897859e-05 Hypothetical protein VI - Unknowns Rv1773c - 7 2.9 3.4 3.8 2.6 4.95425629196874 0.142589508557862 1.27705753389633 0.111654725627606 0.911097178490153 NA Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1774 - 30.3 24.8 6.1 18.5 1.5 34.0823518012207 -0.396301160476316 0.67633245988014 -0.585956144329593 0.557904986455136 0.732431231291361 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1775 - 70.8 40.4 32.5 24.2 8.4 49.2413558507054 -0.819861377491473 0.476012689230163 -1.7223519373347 0.0850057845845252 0.207505505856918 hypothetical protein V - Conserved hypotheticals Rv1776c - 21.6 11.5 3.6 6.9 0 6.98110898763546 -1.02139599034994 1.20512164921242 -0.847545964357587 0.396690878490955 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv1777 cyp144 5.2 7.3 4.7 4.2 4.6 15.7538888429975 0.512472753195654 0.8362732970379 0.612805353239 0.54000505080573 0.719329781855545 Probable cytochrome P450 144 Cyp144 IV.F - Cytochrome P450 enzymes Rv1778c - 123.2 39 50.9 37.9 16.3 42.0020137168033 -0.591710192478349 0.532015834902882 -1.11220409931288 0.266050405778696 0.46013209827546 hypothetical protein VI - Unknowns Rv1779c - 114.1 63 60.9 32.8 14.1 181.108540501133 -0.973383364238695 0.325841531615735 -2.98729066062274 0.00281461982391199 0.0145579135427629 Possible integral membrane protein II.C.5 - Other membrane proteins Rv1780 - 47.6 40.1 22.2 55.2 9.9 35.1172339877511 0.510061233404432 0.551731129060481 0.924474271141802 0.35523944115468 0.554787522297124 hypothetical protein V - Conserved hypotheticals Rv1781c malQ 7.8 2.4 3 5.3 2.1 16.1831393727299 0.425448216374924 0.747414986668901 0.56922623169636 0.569202621078966 0.741219001419742 Probable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme) II.A.8 - Polysaccharides (cytoplasmic) Rv1782 eccB5 219 91 111.6 191.7 68.5 412.691170689818 0.697244653832232 0.284623743731702 2.44970656590577 0.0142972675683787 0.053194245511762 ESX conserved component EccB5 ESX-5 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv1783 eccC5 228.6 106.9 110.4 220 73 1225.67991830624 0.769875915327883 0.241329119231547 3.19014927738253 0.00142199322275454 0.00831138613035737 ESX conserved component EccC5 ESX-5 type VII secretion system protein V - Conserved hypotheticals Rv1785c cyp143 17.9 8.3 10 10.1 4.2 22.3579612902658 0.000553918345580227 0.649166719300034 0.00085327594454856 0.999319184380355 0.999585202738999 Probable cytochrome P450 143 Cyp143 IV.F - Cytochrome P450 enzymes Rv1786 - 41.6 13.5 33.4 89.4 37.9 19.5276094550543 1.88171381864515 0.710976935926575 2.64665943937101 0.00812911739432886 0.0341557933697661 Probable ferredoxin I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1787 PPE25 18.5 9.9 9.2 14.4 3.6 21.7704017680702 0.25567258791429 0.646087479448399 0.395724412013946 0.692308344370555 0.829929298176099 PPE family protein PPE25 IV.C.2 - PPE family Rv1788 PE18 39.9 23.7 13.2 33.8 1.1 10.040577689768 0.109945969114909 0.987799818508118 0.111303896857322 0.91137536536356 0.957038702673504 PE family protein PE18 IV.C.1.a - PE subfamily Rv1789 PPE26 168.2 106.6 90.2 105.4 16.1 199.679279340446 -0.379352411228838 0.344146851548414 -1.10229807281986 0.270332106931439 0.465944682603969 PPE family protein PPE26 IV.C.2 - PPE family Rv1790 PPE27 10.2 6 6.1 15.6 1.9 14.4332686961045 0.783898015977434 0.807422251807235 0.970865014213879 0.331615502096389 0.531725716806432 PPE family protein PPE27 IV.C.2 - PPE family Rv1791 PE19 296.4 227.3 241.9 278.9 311.8 206.983735729711 1.32069660805846 0.438445346055616 3.01222631267463 0.00259339173734373 0.0137306330847108 PE family protein PE19 IV.C.1.a - PE subfamily Rv1793 esxN 664.1 412.2 356.6 774.3 341.1 311.489105198022 1.06636217672354 0.283645662432646 3.75948698660871 0.000170262133194461 0.00140248482738321 Putative ESAT-6 like protein EsxN (ESAT-6 like protein 5) V - Conserved hypotheticals Rv1794 - 409.5 369.1 255.6 324.2 168.4 570.638060439071 0.382693870218428 0.300502488354625 1.27351314897202 0.202836009638552 0.38235505382637 hypothetical protein V - Conserved hypotheticals Rv1795 eccD5 182.8 108.6 83 97.8 23.7 265.073173739023 -0.319796030682881 0.291153871993022 -1.09837464462965 0.272040929439057 0.467524974319816 ESX conserved component EccD5 ESX-5 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv1796 mycP5 384.4 243.6 164.3 237.9 38.6 648.7915350937 -0.335672276126165 0.302116121071308 -1.11107038888182 0.266538052434993 0.460750503525987 Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) V - Conserved hypotheticals Rv1797 eccE5 344.8 294.6 201.4 101.7 42.9 430.518188859213 -1.17420597714382 0.293055711344815 -4.00676708109682 6.15555116907599e-05 0.000595709350843365 ESX conserved component EccE5 ESX-5 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv1798 eccA5 227.8 191.7 119.1 71.8 32.2 423.411927978272 -0.981949238844942 0.295320187496165 -3.32503255930546 0.000884082099558929 0.00555216098694633 ESX conserved component EccA5 ESX-5 type VII secretion system protein V - Conserved hypotheticals Rv1799 lppT 27.1 8.2 14.2 69.6 8.1 8.54101150163394 1.86741960232557 1.03054300559655 1.8120734333106 0.069974850702285 0.178492016644115 Probable lipoprotein LppT II.C.1 - Lipoproteins(lppA-lpr0) Rv1800 PPE28 18.2 8.3 15.3 21.6 6 54.2507146387605 0.678161444138933 0.485947047955088 1.39554596944812 0.162851262598991 0.32904687514297 PPE family protein PPE28 IV.C.2 - PPE family Rv1801 PPE29 2.7 0.6 1.7 2.5 0 2.62886568047472 0.298531824408522 1.84583345469565 0.161732806201493 0.871516269025359 NA PPE family protein PPE29 IV.C.2 - PPE family Rv1802 PPE30 2.5 3.7 2.3 3.8 1.4 6.76179767744831 0.514149396692922 1.10990208351667 0.463238518359986 0.643193409565741 NA PPE family protein PPE30 IV.C.2 - PPE family Rv1803c PE_PGRS32 10.4 8.6 6 15.1 5 35.2166989039665 1.07465802444385 0.525270732494145 2.04591262745794 0.0407649677412864 0.120224409441829 PE-PGRS family protein PE_PGRS32 IV.C.1.b - PE_PGRS subfamily Rv1804c - 17.9 0 10.1 31.3 6 7.49231938983129 1.47216160090278 1.13772384727169 1.29395336525035 0.195681529625233 0.372583028402359 hypothetical protein V - Conserved hypotheticals Rv1805c - 3.1 2.9 0 0.7 5.3 1.97403266429109 1.01084559329057 2.14915631830354 0.470345309311189 0.638108331126604 NA Hypothetical protein VI - Unknowns Rv1806 PE20 4.9 14.7 3.5 28 17.7 10.1540122548179 2.73913973709248 1.03597398785775 2.64402366198078 0.00819269287461461 0.0342603520211156 PE family protein PE20 IV.C.1.a - PE subfamily Rv1807 PPE31 17.5 11 4.5 25.1 2.2 24.3999947196912 0.991994566486035 0.679523586125821 1.45983831428385 0.144334515760012 0.303222333820855 PPE family protein PPE31 IV.C.2 - PPE family Rv1808 PPE32 14.8 8.3 6.6 22.2 6 27.9558971405725 1.29332739079347 0.576288788636728 2.24423486331041 0.0248172940021271 0.0819989322346402 PPE family protein PPE32 IV.C.2 - PPE family Rv1809 PPE33 25.1 24.5 9.7 24.9 4.6 44.6428776588436 0.269099336396644 0.525966598585731 0.511628185364288 0.60891125554366 0.768899703078661 PPE family protein PPE33 IV.C.2 - PPE family Rv1810 - 260.4 144.7 121.7 118.1 44.3 89.0975320311617 -0.327919155759665 0.37990299941154 -0.863165482419468 0.388046488949951 0.5888863169926 hypothetical protein V - Conserved hypotheticals Rv1811 mgtC 41.5 26.9 21.5 26.5 2.6 27.406162830873 -0.406053856978766 0.643344085238425 -0.631161249937163 0.527935095953997 0.708044721646746 Possible Mg2+ transport P-type ATPase C MgtC III.A.2 - Cations Rv1812c - 165.4 69.7 119.9 121.7 36.3 235.191506462562 0.0992411997317706 0.348244413672075 0.284975711987217 0.775662749756416 0.881423631580758 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1813c - 2645.1 1901 3372.3 1426.7 997.7 1879.65300397412 -0.219088833385947 0.64129381009043 -0.341635658942432 0.732625098170873 0.85642181442945 hypothetical protein V - Conserved hypotheticals Rv1814 erg3 54.7 29.3 33.3 55.1 13.1 63.4671676292311 0.515383467735842 0.429906762158223 1.19882614813619 0.230595552903892 0.415025126212188 Membrane-bound C-5 sterol desaturase Erg3 (sterol-C5-desaturase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1815 - 220.4 138.9 93.6 63.8 42.1 136.992116628035 -0.6256406418669 0.379589650194289 -1.64820258283299 0.0993111070106701 0.232338138065914 hypothetical protein V - Conserved hypotheticals Rv1816 - 90.6 31.1 49.7 58.7 13.2 60.6019171410129 0.00588250968458224 0.470176929134498 0.0125112682483396 0.990017712653556 0.996155108273772 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv1817 - 28.4 20.3 14.2 43 6.6 60.9104005934801 0.900252775925842 0.453322601754888 1.98589872298626 0.047044570566351 0.134272255395661 Possible flavoprotein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1818c PE_PGRS33 107.9 54.3 59.8 75.4 9.9 158.819892379791 -0.209474730905265 0.382083792091514 -0.548242912264369 0.583525120361697 0.752675155251687 PE-PGRS family protein PE_PGRS33 IV.C.1.b - PE_PGRS subfamily Rv1819c bacA 12.5 8.4 4.8 5.5 1 19.7644939639533 -0.700837257440879 0.717186334255485 -0.977203864555537 0.328468235166644 0.528833858618298 Probable drug-transport transmembrane ATP-binding protein ABC transporter BacA III.A.6 - Efflux proteins Rv1820 ilvG 71.1 35.3 28.6 26.2 10.2 100.236076949306 -0.495886025251201 0.374042441292851 -1.3257480181586 0.184923176350222 0.358313944547312 Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) I.D.7 - Branched amino acid family Rv1821 secA2 373.5 232.5 191.2 210.7 62.9 951.723752256462 -0.221904952489668 0.234513335992543 -0.946235963726702 0.344028246702189 0.54487031010848 Possible preprotein translocase ATPase SecA2 III.D - Protein and peptide secretion Rv1822 pgsA2 59.2 42.4 27.8 37.5 15.7 43.6833075062207 0.0887820954585136 0.488839296845298 0.181618163743105 0.855882393315094 0.921719500493178 Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA2 (PGP synthase) (phosphatidylglycerophosphate synthase) (3-phosphatidyl-1'-glycerol-3'phosphate synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1823 - 41.1 15.3 26.7 11.3 2.1 28.8484030164393 -1.41443792417827 0.663715157999248 -2.13109179010172 0.0330815809460143 0.101856570706718 hypothetical protein V - Conserved hypotheticals Rv1824 - 49.6 28.1 10.8 26.2 3.9 13.9914887145994 -0.217256973974161 0.835883613393092 -0.259912947799338 0.794930923528406 0.893855660678608 hypothetical protein II.C.5 - Other membrane proteins Rv1825 - 75.6 51.6 48.4 22.9 4.8 60.2512860379618 -1.39588542587864 0.475426961352046 -2.93606702890586 0.00332402488585293 0.0164667078960714 hypothetical protein VI - Unknowns Rv1826 gcvH 234 99.6 120 228.5 98.8 131.497364232118 0.932002896710858 0.350665074063445 2.65781500823841 0.00786490510841412 0.0334825647764457 Probable glycine cleavage system H protein GcvH I.C.1 - General Rv1827 garA 836.7 544.1 379.5 783.5 235.5 526.191625338814 0.548617760602632 0.251211216896092 2.18389038268763 0.0289703038873245 0.0922777125619633 Conserved protein with FHA domain, GarA V - Conserved hypotheticals Rv1828 - 306.2 154.9 140.5 264.6 56.3 251.07485739159 0.3634868733721 0.3037503499994 1.19666322482532 0.231437846409861 0.415907078632028 hypothetical protein V - Conserved hypotheticals Rv1829 - 344 247.3 222.2 307.7 147.1 261.657126094144 0.57309672933554 0.3085569985573 1.85734477589272 0.0632621178906726 0.165613024071517 hypothetical protein V - Conserved hypotheticals Rv1830 - 217.1 112 95.1 229.8 83.1 202.90826941747 0.952008277788234 0.297972757283198 3.19495072793997 0.00139854714857929 0.00822624925266541 hypothetical protein V - Conserved hypotheticals Rv1831 - 1078.9 629.6 468.3 1220 264.5 355.967391056659 0.709945413744417 0.284202984036009 2.49802237704325 0.0124888310105148 0.0479257198691695 Hypothetical protein VI - Unknowns Rv1832 gcvB 329.3 186.8 198.4 288.1 138.9 1353.73259267154 0.723485149128057 0.266931009849776 2.71038254242256 0.00672056471141493 0.0294971997618732 Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein) I.C.1 - General Rv1833c - 18.1 14.9 11.3 14.5 3.6 19.0788941253597 -0.0434788752724287 0.697836627066882 -0.0623052353316239 0.950319759387521 0.977994521000095 Possible haloalkane dehalogenase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv1834 lipZ 19.1 13.9 5.8 22.7 13.6 29.4411137705646 1.46754433355805 0.605484247403865 2.42375311967312 0.0153610442234183 0.0564765626706628 Probable hydrolase V - Conserved hypotheticals Rv1835c - 65.6 33.2 30.6 16.3 4 93.0974365139385 -1.33884949879545 0.397784670881565 -3.36576443689576 0.000763318638336377 0.00491577203088627 hypothetical protein V - Conserved hypotheticals Rv1836c - 362.4 206.6 174 178.8 57.5 722.404165596629 -0.302013518966203 0.240294315083038 -1.25684837305384 0.208808545976025 0.38933530019983 hypothetical protein V - Conserved hypotheticals Rv1837c glcB 367.7 257.8 190.2 309.4 91.4 1035.48013580852 0.284010550630343 0.236441946455879 1.20118513185789 0.22967939552563 0.413796754298974 Malate synthase G GlcB I.B.4 - Glyoxylate bypass Rv1838c vapC13 69.3 34.3 18.5 46.5 25.9 30.6736553151963 0.690850380321641 0.58723898890228 1.17643820212456 0.239419813525282 0.426357455759955 Possible toxin VapC13 V - Conserved hypotheticals Rv1839c vapB13 67.2 51.8 25.2 33.9 16.2 18.4943717567803 -0.213000527439018 0.712063278563413 -0.299131459030925 0.764839743743452 0.876096305656509 Possible antitoxin VapB13 V - Conserved hypotheticals Rv1840c PE_PGRS34 15.9 6.6 3.7 6.3 0.7 15.5753424093403 -0.463021868770722 0.81044263857663 -0.571319729159267 0.567782930447642 0.739914326580408 PE-PGRS family protein PE_PGRS34 IV.C.1.b - PE_PGRS subfamily Rv1841c - 97.2 59.5 50.9 28.3 3.6 81.4923718008208 -1.40430372878625 0.443993815784162 -3.16289029005062 0.00156211188457915 0.00896062955605706 hypothetical protein II.C.5 - Other membrane proteins Rv1842c - 112.5 74.5 49.7 81.2 19.7 167.129220807089 0.0671793033918001 0.323717572576766 0.207524425866221 0.835600318776698 0.913196861927262 hypothetical protein II.C.5 - Other membrane proteins Rv1843c guaB1 246.1 127.5 101.9 168.4 45.5 363.829676083821 0.182324072415816 0.271614923656119 0.671259406374332 0.502055289858358 0.687051667949455 Probable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv1844c gnd1 207.7 139.1 119.3 149 50.4 372.161250039542 0.111971633829179 0.26754582974985 0.41851384465185 0.675571466346861 0.819477443082391 Probable 6-phosphogluconate dehydrogenase Gnd1 I.B.5 - Pentose phosphate pathway Rv1845c blaR 273.9 117.7 79.9 150.9 34.1 215.367317725406 -0.000350119483773157 0.338486358761909 -0.00103436807632012 0.999174693828885 0.999585202738999 Possible sensor-transducer protein BlaR VI - Unknowns Rv1846c blaI 2004.5 1223.6 735.6 1246.8 391.5 861.165061888849 0.106884659045819 0.253337759660831 0.421905756129352 0.673093808407681 0.817591999101511 Transcriptional repressor BlaI I.J.1 - Repressors/activators Rv1847 - 55.9 36.8 26 68.9 12.4 30.9226876503364 0.714238502172301 0.567301706513712 1.25900996589905 0.208026732242088 0.388759864896304 hypothetical protein V - Conserved hypotheticals Rv1848 ureA 84 72.5 60.1 49.1 44 40.7338993696171 0.226024177188532 0.568655851397347 0.397470942456896 0.691020210064157 0.829411583885884 Urease gamma subunit UreA (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1849 ureB 43.6 23.7 15.8 23.9 1.9 10.1330663713726 -0.480345368318821 0.990030802078491 -0.48518224615878 0.627547074608778 0.783217666759793 Urease beta subunit UreB (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1850 ureC 50.1 40.3 43.1 20.5 6.9 102.462978700456 -1.01695847352408 0.408471511270369 -2.48966805631385 0.0127862452699038 0.0485411369196133 Urease alpha subunit UreC (urea amidohydrolase) I.A.2 - Amino acids and amines Rv1851 ureF 34 22.6 19.5 5.3 3 17.3739772013949 -2.12058799399812 0.803018442847647 -2.64077122124137 0.00827175549128705 0.0345094911073483 Urease accessory protein UreF I.A.2 - Amino acids and amines Rv1852 ureG 29.7 19.7 13.6 6.8 0 14.3503471767917 -1.8067584968156 0.895382455301587 -2.01786229573489 0.0436056047841965 0.126703078052193 Urease accessory protein UreG I.A.2 - Amino acids and amines Rv1853 ureD 35.2 32.5 17.1 11.2 6.2 22.7200028666868 -0.970790445818607 0.682524485182885 -1.42235255568667 0.15492392895748 0.318479719307831 Probable urease accessory protein UreD I.A.2 - Amino acids and amines Rv1854c ndh 152.1 74.7 69.5 213.7 57.8 317.867308094584 1.19748223656914 0.276648488506038 4.32853345064636 1.501055367675e-05 0.000185252199035013 Probable NADH dehydrogenase Ndh I.B.6.a - aerobic Rv1855c - 161.6 101.1 83.7 162.4 53.2 205.6872071659 0.657020129444213 0.293502730911073 2.23854860704271 0.0251853013754795 0.0829826395087893 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1856c - 130.7 65.5 75.6 144.6 46.5 125.270264163019 0.82055976977994 0.344621033246284 2.38104958960391 0.0172633878117784 0.0622043943329799 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1857 modA 68.3 47.7 26.4 46.3 9.9 54.6242518566125 -0.0409544991674113 0.465898604002727 -0.0879043182691563 0.929952724410983 0.967937863609668 Probable molybdate-binding lipoprotein ModA III.A.4 - Anions Rv1858 modB 9.2 0 5.6 2.4 0 3.87963708108181 -1.28769746080808 1.65050809990379 -0.780182454653294 0.435283488169268 NA Probable molybdenum-transport integral membrane protein ABC transporter ModB III.A.4 - Anions Rv1859 modC 148.9 75.6 60.2 100.6 14.4 151.263480882765 -0.0765395828171449 0.372644719408773 -0.205395592183837 0.837263063794315 0.91350881138875 Probable molybdenum-transport ATP-binding protein ABC transporter ModC III.A.4 - Anions Rv1860 apa 41.8 19.7 16.6 12.2 10 37.1543654568378 -0.366104077995269 0.575594849045373 -0.636044743281588 0.524747259411201 0.706175833143798 Alanine and proline rich secreted protein Apa (fibronectin attachment protein) (immunogenic protein MPT32) (antigen MPT-32) (45-kDa glycoprotein) (45/47 kDa antigen) III.A.4 - Anions Rv1861 - 40.2 13.2 7.4 34.1 12.6 12.0916636630245 1.11413788270436 0.885073503790728 1.25880831132393 0.208099577595537 0.388759864896304 Probable conserved transmembrane protein VI - Unknowns Rv1862 adhA 51.2 33.2 25.4 30.4 12.2 59.5640053527306 -0.0271436999954473 0.432807656072301 -0.0627153878047686 0.94999314381924 0.977994521000095 Probable alcohol dehydrogenase AdhA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1863c - 158.8 80.3 104.2 98.4 23 129.956649866663 -0.228263494262811 0.366526438968528 -0.622774976084087 0.533432404766641 0.713256918717796 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv1864c - 16.7 16.2 8.3 19.3 2.6 15.7522347709622 0.322103343504343 0.784148451276368 0.410768321967673 0.681242423545985 0.821853087261539 hypothetical protein V - Conserved hypotheticals Rv1865c - 11.6 7.6 5 17 4.6 15.0355342950516 1.18406076845233 0.754538665698792 1.56925128198136 0.116589399222605 0.261058638720299 Probable short-chain type dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1866 - 7.8 5.7 3.2 4.2 5.1 27.9196109892485 0.802973929138971 0.669096992331074 1.2000859940223 0.230105944486712 0.414354476549026 hypothetical protein V - Conserved hypotheticals Rv1867 - 26.8 22 13.1 11 6.6 44.7467920182098 -0.434574385249288 0.516812146700281 -0.840874944646596 0.400417996179601 0.599442325641651 hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1868 - 18.3 6.5 8.4 16.8 7.4 49.9784981928467 0.957715663511257 0.478335850270402 2.00218248949951 0.0452651082463862 0.130199350841148 hypothetical protein V - Conserved hypotheticals Rv1869c - 533.1 324.2 259.5 172.4 45.1 564.968746652101 -1.05575254584172 0.257700987073451 -4.0968121924221 4.18878461402579e-05 0.000436372797143511 Probable reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1870c - 1802.3 1159 1118.2 1510.6 588 1574.86948451432 0.419706320990428 0.243831804086079 1.72129440851063 0.0851974136182086 0.207763457504727 hypothetical protein VI - Unknowns Rv1871c - 6002.9 3233.8 2797.6 8585.9 2662.4 3749.93236410773 1.25470689485723 0.217540306749129 5.7676984721005 8.0361419372781e-09 2.01872444977582e-07 hypothetical protein VI - Unknowns Rv1872c lldD2 4624.9 2634.6 2406.3 4327.2 1577 7790.18449375446 0.680305242272558 0.219474680358445 3.0996980661345 0.00193718007653701 0.0107715727332717 Possible L-lactate dehydrogenase (cytochrome) LldD2 I.B.6.a - aerobic Rv1873 - 5.4 0 6.2 2.8 0.6 2.07179007420116 -0.652189424270635 2.04518286524054 -0.318890518473969 0.749809534433122 NA hypothetical protein VI - Unknowns Rv1874 - 34.8 25 12.5 27.1 3.1 22.6450368282678 -0.0340212212560906 0.694452878552938 -0.0489899636199681 0.96092729420811 0.983985104390034 hypothetical protein VI - Unknowns Rv1875 - 75 36.6 30.7 49.3 35.3 43.2158666576535 0.759100599120459 0.526349360080554 1.44219914887763 0.149246200639032 0.30914037582658 hypothetical protein V - Conserved hypotheticals Rv1876 bfrA 106.8 81.6 88.3 235.3 125.7 148.843133028504 1.83195045662796 0.373134533671195 4.90962452229702 9.12509419006974e-07 1.53180491095863e-05 Probable bacterioferritin BfrA I.G.14 - Iron utilisation Rv1877 - 46 28.6 22.9 36.5 24.4 143.356395878084 0.849613618396502 0.371175098706068 2.2889833433285 0.0220803201935542 0.0751282364318627 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv1878 glnA3 15 11.9 7.5 10.4 4.1 24.33520382499 0.0760019740191936 0.61896578342131 0.122788651739512 0.902274460854693 0.951569220060685 Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) I.D.1 - Glutamate family Rv1879 - 13.6 9.1 7.8 10.1 0 14.8041861465934 -0.349793854691481 0.850984597166033 -0.411046046962979 0.681038770521346 0.821853087261539 hypothetical protein V - Conserved hypotheticals Rv1880c cyp140 185.1 116.2 101.3 165 62.2 332.061369358697 0.55144629205983 0.271627262997627 2.03015811437399 0.0423404698857277 0.123533726800039 Probable cytochrome P450 140 Cyp140 IV.F - Cytochrome P450 enzymes Rv1881c lppE 315.9 196.9 122.2 187.2 54 133.851031455144 -0.0411311687816683 0.340408749639563 -0.120828764904602 0.903826665920799 0.952219708896739 Possible conserved lipoprotein LppE II.C.1 - Lipoproteins(lppA-lpr0) Rv1882c - 148.2 87.7 54.6 92.7 24.4 121.877778814376 0.0459872625644382 0.352752984639267 0.130366756815583 0.896276266316152 0.947927899460081 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1883c - 800.7 433.5 292.5 472.9 110.9 344.088906884975 -0.0685122562869752 0.289922466599791 -0.236312339262585 0.813190312712437 0.901508634625181 hypothetical protein V - Conserved hypotheticals Rv1884c rpfC 1165.5 689.6 468 183 122 480.025466041405 -1.37203783099147 0.322980030666371 -4.2480577767012 2.15631790616448e-05 0.000247976559208916 Probable resuscitation-promoting factor RpfC V - Conserved hypotheticals Rv1885c - 51 23.2 16 16.1 5.5 21.3988349374137 -0.752732765479026 0.685210733042718 -1.09854199471814 0.271967890605663 0.467524974319816 Chorismate mutase VI - Unknowns Rv1886c fbpB 143.2 76.8 54.3 67.9 14.5 119.327982698108 -0.397367869070407 0.364137373760482 -1.09125812867476 0.275159316435218 0.471577094280145 Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular alpha-antigen) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv1887 - 254.8 135.8 95.8 238.8 71.4 350.916535853399 0.714117438888649 0.273473894576096 2.61128192873979 0.00902034964744371 0.0365270761792879 Hypothetical protein VI - Unknowns Rv1888c - 47 36.5 17.6 84.7 3.5 34.9655188872398 0.900999320969456 0.649647099260663 1.38690578622586 0.165470493235753 0.332631377435323 Possible transmembrane protein VI - Unknowns Rv1888A - 9.2 4 11.2 9.4 0 1.72135273518615 -0.0296204607392509 2.18150130913511 -0.0135780164858092 0.989166643158184 NA hypothetical protein ? Rv1889c - 13.4 8.4 5.9 8.7 0.8 3.64857824682642 -0.264943484681889 1.515549011367 -0.17481683712948 0.861223557951076 NA hypothetical protein V - Conserved hypotheticals Rv1890c - 9.8 8.5 1.8 5.4 5.1 7.13701925249722 0.436263564074262 1.14880296291158 0.379754908508048 0.704127356938346 NA Hypothetical protein VI - Unknowns Rv1891 - 227.2 132.4 94.9 290.2 66.7 127.731057394814 0.95817233269615 0.343100112388259 2.79269023267432 0.00522717219704491 0.0238590772189859 hypothetical protein VI - Unknowns Rv1892 - 78.2 50.1 60.7 151 60.9 56.2676067046855 1.52145933294983 0.456834442878607 3.3304391922877 0.00086709099923912 0.00547457454421562 Probable membrane protein VI - Unknowns Rv1893 - 80.8 86.7 59.6 193.6 140.4 64.6688968776572 2.11142313347587 0.491889126686776 4.29247775346817 1.76690258318907e-05 0.000210012380860929 hypothetical protein VI - Unknowns Rv1894c - 81.5 28.9 40.1 127.4 41 152.276158297882 1.52391119967835 0.345875166733483 4.40595725350995 1.05317732739799e-05 0.000135157757016076 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1895 - 10.3 6.5 5.5 15.7 6.1 20.5585180221426 1.29942990803013 0.654560405308682 1.98519479255293 0.0471228034666838 0.13431649136846 Possible dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1896c - 30.3 12.6 10.1 15.6 11.6 30.6535943317709 0.570238558939369 0.607172018602799 0.939171341017296 0.347642780701281 0.548485848215563 hypothetical protein V - Conserved hypotheticals Rv1897c - 18.4 10.5 13.7 12.8 2.7 8.96095238671259 -0.155243815244415 0.979498918157387 -0.158493095159774 0.874068261161246 0.935276396979876 hypothetical protein V - Conserved hypotheticals Rv1898 - 119.7 56.3 51.7 64.3 18.4 32.9286005101923 -0.14093418052593 0.552473180122989 -0.255096872746937 0.798648279470988 0.895213176410089 hypothetical protein VI - Unknowns Rv1899c lppD 299.4 115.2 133.2 219.9 31.2 284.517881384224 0.0692768941405775 0.355638445330812 0.194795852501652 0.845552769319664 0.915606208783323 Possible lipoprotein LppD II.C.1 - Lipoproteins(lppA-lpr0) Rv1900c lipJ 104.6 66.1 34.8 96.9 14.4 153.411814843118 0.339315594831136 0.382915919425609 0.886136035660583 0.375544226703998 0.576583290414201 Probable lignin peroxidase LipJ II.B.5 - Esterases and lipases Rv1901 cinA 78.6 45.2 38.4 44.3 13.7 104.350453053486 -0.132038898227444 0.357346381881543 -0.369498349282893 0.711756303337124 0.843721829457863 Probable CinA-like protein CinA III.E - Adaptations and atypical conditions Rv1902c nanT 16.2 8.6 4.2 9.8 1.6 16.000328393334 -0.0789531134704464 0.787009137133645 -0.100320453404138 0.920089919936333 0.961344689207815 Probable sialic acid-transport integral membrane protein NanT III.A.3 - Carbohydrates, organic acids and alcohols Rv1903 - 56.4 68.1 46.4 39.1 23 37.496513855978 -0.171864354647945 0.567793785653468 -0.302687981077758 0.76212765809077 0.875802258232129 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv1904 - 263.3 174.6 130.5 436.6 200.6 236.632616238825 1.62057398885053 0.301739976204216 5.37076329506216 7.84040672638197e-08 1.59601842671523e-06 hypothetical protein V - Conserved hypotheticals Rv1905c aao 193.8 124.1 99.6 110.7 47.7 212.324805166384 -0.00820227679100262 0.303158213318333 -0.0270560929265993 0.978414994696701 0.992708654029137 Probable D-amino acid oxidase Aao I.A.2 - Amino acids and amines Rv1906c - 831.5 545.4 386.3 442.7 185.9 426.631517934586 -0.0621539962265072 0.269894105584226 -0.230290306236832 0.817866192707169 0.903581426877352 hypothetical protein V - Conserved hypotheticals Rv1907c - 28.2 7.8 10.8 29 15.5 25.129686315281 1.40538204755016 0.648762575114308 2.16625018374795 0.0302920741945922 0.095457764054489 Hypothetical protein VI - Unknowns Rv1908c katG 112.2 60.2 48.2 216.1 75.3 499.677836292655 1.79857802180449 0.253032452536057 7.10809227740538 1.17657888266733e-12 6.72168129420596e-11 Catalase-peroxidase-peroxynitritase T KatG III.F - Detoxification Rv1909c furA 44.1 21.7 33.9 67.9 48.7 47.9505268532723 1.71264731175985 0.527536280036011 3.24650147596094 0.00116832842252062 0.00708599190508225 Ferric uptake regulation protein FurA (fur) I.J.1 - Repressors/activators Rv1910c - 48 33.6 23.4 28.5 16.8 35.5051637162505 0.18676942671392 0.544763961115772 0.342844681449528 0.731715309908916 0.855640682633669 Probable exported protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1911c lppC 152.5 103.5 57.6 87.3 27.3 94.4239350969798 -0.0728303805401699 0.380049670736937 -0.191633847225674 0.848029027604025 0.91718647671135 Probable lipoprotein LppC II.C.1 - Lipoproteins(lppA-lpr0) Rv1912c fadB5 20.6 17.2 8 24.3 5.2 27.5078058093691 0.68810171022951 0.598496323450062 1.14971752251194 0.250260234891816 0.441885220332408 Possible oxidoreductase FadB5 I.A.3 - Fatty acids Rv1913 - 10.7 3.9 8.5 9.6 5.2 11.4201305430129 0.76157612959987 0.893437326551011 0.852411363357548 0.393985815400257 0.59433464997773 hypothetical protein VI - Unknowns Rv1914c - 28.1 36.2 12.7 39.5 4.8 16.913126503828 0.388149280693864 0.791153896455553 0.490611602158329 0.62370117888597 0.780894158930401 hypothetical protein VI - Unknowns Rv1915 aceAa 170.3 87.3 71.8 169.3 57.3 244.398861286302 0.843255387510391 0.286051190243903 2.94791777230986 0.00319922148830249 0.0160051447903495 Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) I.B.4 - Glyoxylate bypass Rv1916 aceAb 119.6 80.5 80.8 130 55.9 235.458452307918 0.780265924637569 0.30929369180144 2.52273468654667 0.0116446219844676 0.0451353356669073 Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) I.B.4 - Glyoxylate bypass Rv1917c PPE34 3 0.4 1.9 1.9 0.5 11.0895718868273 -0.0433568093608867 0.981672144080856 -0.0441662826253279 0.964771858381534 0.98505723293217 PPE family protein PPE34 IV.C.2 - PPE family Rv1918c PPE35 24.2 23.7 15.9 13.4 3.3 85.6743694779685 -0.662060660643165 0.417310429594498 -1.58649440246795 0.112627200911234 0.254254649858247 PPE family protein PPE35 IV.C.2 - PPE family Rv1919c - 159.4 105.3 89.9 124 55.1 99.4456020963928 0.383892540821699 0.36961458304298 1.03862931397666 0.298977167085837 0.494849124214035 hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1920 - 30.6 11.3 14.8 48.5 18 45.9192214158764 1.62288767656942 0.487077157553369 3.33189034099099 0.000862582380172537 0.0054558335545913 Probable membrane protein II.C.5 - Other membrane proteins Rv1921c lppF 5 2.6 4.1 3 3.1 9.94027897554833 0.370736177063086 0.977898366935564 0.379115243054205 0.704602287427978 0.838305512053535 Probable conserved lipoprotein LppF II.C.1 - Lipoproteins(lppA-lpr0) Rv1922 - 35.8 28.4 25.3 21 13.3 55.8092896043047 -0.00485019876348895 0.481482281390933 -0.0100734730039856 0.991962667347884 0.996463915980206 Probable conserved lipoprotein II.C.3 - Murein sacculus and peptidoglycan Rv1923 lipD 127.1 66.5 74.4 72.6 34.9 197.768463702047 0.0925925693803232 0.326810415137667 0.283321966165978 0.776930040274167 0.882297596233119 Probable lipase LipD II.B.5 - Esterases and lipases Rv1924c - 46.7 4.5 11.4 10.5 0.6 7.29368398708271 -1.08646872480307 1.26478241768504 -0.859016309533821 0.390331517927853 0.591087745404213 hypothetical protein VI - Unknowns Rv1925 fadD31 1855.5 1170 826.6 973.4 331.1 3526.95438601681 -0.181611991982437 0.220905116124034 -0.822126690268527 0.411004796486428 0.607080479213898 Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) I.A.3 - Fatty acids Rv1926c mpt63 35.7 16 15.3 165 53.7 64.1923202040325 3.05412192331909 0.442310200032667 6.90493215642218 5.02274261494471e-12 2.37207391228455e-10 Immunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein) VI - Unknowns Rv1927 - 335.4 200.1 224.1 341.2 131 391.024365894812 0.668881886998243 0.283598320981778 2.35855376252817 0.0183463020884352 0.0652435763024472 hypothetical protein VI - Unknowns Rv1928c - 13.2 4.3 7 31.8 12.1 23.0997007707787 2.14941791133614 0.646665203120551 3.32384965352071 0.000887840464919173 0.00556589544556409 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1929c - 168.7 42.8 47.6 210.4 48 127.577065936954 1.36237641132838 0.409460937606504 3.32724391071863 0.000877095653286192 0.00552082008873878 hypothetical protein VI - Unknowns Rv1930c - 3.8 0 0 3.2 3.2 2.22455162540209 1.97245381559574 2.06526870296127 0.95505917112265 0.339547774735417 NA hypothetical protein V - Conserved hypotheticals Rv1931c - 9.6 3.3 2.1 6.9 5.1 8.68458658391967 1.23004791891017 1.03013124064753 1.19406913446967 0.232450925739444 0.417304196132341 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1932 tpx 437.8 265.8 155.2 207.3 35.3 183.106609739461 -0.557178060842851 0.357155352432701 -1.56004398939489 0.118749486210439 0.264368749313247 Probable thiol peroxidase Tpx III.F - Detoxification Rv1933c fadE18 2.1 3.2 3.9 0.5 0 3.51324067952184 -2.48033637258655 1.65779472235113 -1.49616616529511 0.134610359212898 NA Probable acyl-CoA dehydrogenase FadE18 I.A.3 - Fatty acids Rv1934c fadE17 1.3 0 0 0.9 0 0.687297761119962 0.99020352668478 3.38080367315669 0.292889981913743 0.769606246517605 NA Probable acyl-CoA dehydrogenase FadE17 I.A.3 - Fatty acids Rv1935c echA13 2 0 2.2 3.3 0 2.28325133057886 0.684902519349896 1.95222239358978 0.350832221574145 0.725714222448682 NA Possible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv1936 - 6 0.1 0.8 10.1 1.9 6.83117221211953 2.01220788922925 1.25667643709309 1.60121398781362 0.109329531766992 NA Possible monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1937 - 6.4 6.1 3.7 9.1 3.8 31.1146435548393 1.09764861782159 0.562355911951771 1.9518753061775 0.0509530107184285 0.141883305003674 Possible oxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1938 ephB 6.9 3.2 4 5.3 3.7 10.2703509391983 0.760361630175961 0.921181357931957 0.825420123441236 0.409133114045494 0.605578558273773 Probable epoxide hydrolase EphB (epoxide hydratase) III.F - Detoxification Rv1939 - 8.7 6.4 4.2 4.7 0 3.80244227980315 -0.617619949478606 1.50278674957755 -0.41098309500814 0.681084930537506 NA Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1940 ribA1 7.2 3.5 3.8 3.8 0 5.84472262560688 -0.591876430556187 1.24601909425997 -0.475013932998924 0.634777042364844 NA Probable riboflavin biosynthesis protein RibA1 (GTP cyclohydrolase II) I.G.9 - Riboflavin Rv1941 - 18.2 8.5 7.6 13 0 11.3481522652311 -0.132662270481726 0.941167299885556 -0.140955035834604 0.88790546380797 0.943076997187058 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv1942c mazF5 435.4 244 222.8 307.1 81.2 156.309977257919 0.0886268224686598 0.322368141484293 0.274924259142332 0.783374428934989 0.885336132396263 Possible toxin MazF5 V - Conserved hypotheticals Rv1943c mazE5 234.8 137.1 122.5 167.9 46.3 98.7208568107273 0.090661693807471 0.365325514653478 0.248166881783404 0.804005289459325 0.897686131592986 Possible antitoxin MazE5 V - Conserved hypotheticals Rv1944c - 24.1 7.7 15.3 14.6 7 15.4525867959235 0.156924822885928 0.781318139236682 0.200846255840467 0.840818792879286 0.91350881138875 hypothetical protein VI - Unknowns Rv1945 - 25.3 10.8 8.5 14.9 11.5 41.7376031872789 0.782738312376103 0.546189908963483 1.43308819795211 0.151832633777003 0.313580868127197 hypothetical protein IV.B.2 - REP13E12 family Rv1946c lppG 2.2 0.3 0 2.9 2.3 0.624598178256337 1.67077630310097 3.50794336791528 0.476283716089146 0.633872264859529 NA Possible lipoprotein II.C.1 - Lipoproteins(lppA-lpr0) Rv1947 - 77.1 59.2 33.3 24.3 5.5 25.7331827755809 -1.25895748949342 0.662055067321141 -1.90159029306658 0.0572247379464082 0.15531802437255 Hypothetical protein VI - Unknowns Rv1948c - 20 20 15.3 34.7 0 10.2378902355532 0.504581014649946 0.98259596813955 0.513518303566136 0.607588810617809 0.767777226974057 Hypothetical protein VI - Unknowns Rv1949c - 11.1 11 8.4 8.9 4.1 16.2708768160602 0.0602943312644847 0.753313283985358 0.0800388530857989 0.936206354785094 0.972161509425038 hypothetical protein V - Conserved hypotheticals Rv1950c - 103.6 101.5 63 62.3 1.4 20.2837123491718 -0.853741724943699 0.775425552568206 -1.10099766781751 0.270897672186529 0.466687742723192 hypothetical protein V - Conserved hypotheticals Rv1951c - 10.9 2.9 13.2 20.2 5.7 5.76010764487988 1.14091983529827 1.27308588033142 0.896184501709542 0.370154231689071 NA hypothetical protein V - Conserved hypotheticals Rv1952 vapB14 74.5 36.3 39.2 23.8 14.7 14.1938306395409 -0.73522345551658 0.812921373060026 -0.904421362116519 0.365772015043128 0.566986642136875 Possible antitoxin VapB14 V - Conserved hypotheticals Rv1953 vapC14 47.5 63.9 27.2 37.1 34.2 29.6786328720273 0.563373521954503 0.656680524592675 0.85791111637421 0.390941545443941 0.591600438191876 Possible toxin VapC14 V - Conserved hypotheticals Rv1954c - 1.3 1.6 0.1 2.5 0 0.575224699699787 1.89363041340958 3.62355752991424 0.522588753670042 0.601260468465803 NA Hypothetical protein VI - Unknowns Rv1954A - 226.8 146.8 100.6 958.1 483.2 304.664857854735 3.11020113770879 0.308552735556724 10.0799661753024 6.77494414054807e-24 1.99973767881844e-21 Hypothetical protein ? Rv1955 higB 30 15.1 24.1 148.5 96.2 66.6499586387546 3.33608369310999 0.490650239836138 6.79931124506153 1.05120492485139e-11 4.65420980477952e-10 Possible toxin HigB VI - Unknowns Rv1956 higA 17.8 8.7 5.2 68.8 21.3 24.7906789103325 2.96261812883797 0.655658670638588 4.51853725346527 6.2268318540929e-06 8.48286093353733e-05 Possible antitoxin HigA I.J.1 - Repressors/activators Rv1957 - 28.5 18 27.1 84.2 44.2 55.1381294397889 2.20790109281422 0.495689504044225 4.45420182352144 8.42058635921524e-06 0.000111706804810264 Hypothetical protein VI - Unknowns Rv1958c - 15.8 14 8.5 9.6 3.8 12.003026234764 -0.129134213975035 0.855387404969715 -0.150965765014517 0.880002721891553 0.939129147616717 Hypothetical protein VI - Unknowns Rv1959c parE1 88.9 56.1 30.3 147.6 15.9 36.1512865100678 1.13409002784465 0.566276801963343 2.00271320300008 0.0452080808196516 0.130184570945696 Possible toxin ParE1 V - Conserved hypotheticals Rv1960c parD1 77.8 71.5 13.1 112.2 10.7 24.402883103898 0.846010128057518 0.721582044419896 1.1724378878325 0.241021295557353 0.428133113773392 Possible antitoxin ParD1 VI - Unknowns Rv1961 - 6.5 0 4.3 4.1 11.6 7.40721655403506 2.00641454149153 1.24125294025201 1.61644293151416 0.105998582603809 0.242850568940938 Hypothetical protein VI - Unknowns Rv1962c vapC35 33.8 22.1 13.8 33.7 2.6 13.0405122569043 0.21285986764063 0.892904347439557 0.238390448261357 0.811578275093719 0.90028507684997 Possible toxin VapC35 Contains PIN domain V - Conserved hypotheticals Rv1962A vapB35 36.8 42 9.6 59.2 14.7 16.9284008381177 1.07864411627475 0.761875640541417 1.41577451604599 0.156841533148428 0.321353243315247 Possible antitoxin VapB35 ? Rv1963c mce3R 14.2 10.3 1.8 11.6 5.9 21.7029617601728 0.937694984094472 0.724987436524297 1.29339480500508 0.195874545959594 0.372603459607348 Probable transcriptional repressor (probably TetR-family) Mce3R I.J.1 - Repressors/activators Rv1964 yrbE3A 5.5 3.6 4.2 6.1 2.5 6.04029145177179 0.558548333459226 1.1546120297909 0.483754126102756 0.628560375087453 NA Conserved hypothetical integral membrane protein YrbE3A IV.A - Virulence Rv1965 yrbE3B 2.3 0 0 2.5 0 1.07835465090062 1.45867076638804 2.83700006398122 0.514159581773523 0.607140423577417 NA Conserved hypothetical integral membrane protein YrbE3B IV.A - Virulence Rv1966 mce3A 2.1 2.7 1.7 3.2 1.5 5.21233150902215 0.750280654975066 1.24040265467762 0.604868630477145 0.545266287930659 NA Mce-family protein Mce3A IV.A - Virulence Rv1967 mce3B 1.8 3.4 1 1 3.8 5.99901573049137 1.49697121277956 1.35616401523592 1.10382755770079 0.269667948209587 NA Mce-family protein Mce3B IV.A - Virulence Rv1968 mce3C 1.6 0 0.8 1.7 0 1.39077914633027 0.870806242967166 2.37057405748227 0.367339818057415 0.713365556457797 NA Mce-family protein Mce3C IV.A - Virulence Rv1969 mce3D 2.2 1.4 2.6 2.1 3 7.13651409114686 1.22670986499039 1.1781259742502 1.04123828164565 0.297764972853497 NA Mce-family protein Mce3D IV.A - Virulence Rv1970 lprM 8.4 3 3.7 3.7 1.9 7.61748324770056 -0.253141986184979 1.05687996166392 -0.239518200143032 0.810703785444929 0.900180115344522 Possible Mce-family lipoprotein LprM (Mce-family lipoprotein Mce3E) II.C.1 - Lipoproteins(lppA-lpr0) Rv1971 mce3F 6.4 3.7 6 2.2 1.5 9.06870408421956 -1.03560682281978 1.03073059158847 -1.00473084942963 0.315026469245955 0.5127866516862 Mce-family protein Mce3F IV.A - Virulence Rv1972 - 5.2 5.9 0.5 2.2 0 2.16651039742302 -0.694970150111338 2.02649346573553 -0.342942211194889 0.731641935288764 NA Probable conserved Mce associated membrane protein V - Conserved hypotheticals Rv1973 - 4 0 9.1 2.6 0 2.57320536866909 -0.991302994658157 1.92881922182936 -0.513942926034286 0.607291894539742 NA Possible conserved Mce associated membrane protein V - Conserved hypotheticals Rv1974 - 7.1 0 2.5 6.9 0 1.70974128761198 0.827485009265902 2.19980387600691 0.37616308357814 0.706795658352821 NA Probable conserved membrane protein V - Conserved hypotheticals Rv1975 - 1.5 0 0 1.7 5.9 4.41623314795606 3.77380212300718 1.71555303063371 2.19975836107682 0.0278240436694154 NA hypothetical protein VI - Unknowns Rv1976c - 60.6 42.3 40.1 42.2 38.6 41.2663952502192 0.683793898606098 0.560354459931084 1.22028813456789 0.222355666221144 0.406180386671115 hypothetical protein VI - Unknowns Rv1977 - 47.2 17.8 25.1 61.2 22.3 75.7077635025723 1.24051215797891 0.409930601944637 3.02615162687085 0.00247688060470392 0.0132524336886122 hypothetical protein II.B.3 - Proteins, peptides and glycopeptides Rv1978 - 28.1 24.6 18.4 39.1 14.6 43.9527800583089 0.928797854543129 0.490323945628036 1.89425350898062 0.058191368726376 0.157098954290262 hypothetical protein IV.H - Miscellaneous transferases Rv1979c - 82.9 52.8 40.5 109.3 32.1 184.873157812451 1.01474612638507 0.301119008225665 3.36991720437854 0.000751907722387 0.00485110592476276 Possible conserved permease II.C.5 - Other membrane proteins Rv1980c mpt64 244.9 166.1 164.9 458 373.4 517.005241418824 2.16679771227871 0.356071857219013 6.08528213715568 1.16286351069892e-09 3.53476988856963e-08 Immunogenic protein Mpt64 (antigen Mpt64/MPB64) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1981c nrdF1 187.2 148 80.7 144.9 41.3 217.062697964743 0.159736580038692 0.31335852969135 0.509756604347193 0.610221991418134 0.769779720429378 Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv1982c vapC36 201.1 173.1 87.4 107.7 95.2 119.121088373485 0.40512816708335 0.43569871520198 0.929835578917284 0.352456221838786 0.552878626108494 Possible toxin VapC36 Contains PIN domain V - Conserved hypotheticals Rv1982A vapB36 443.6 294.5 297.2 99.6 222.8 159.499168237066 0.281973274707752 0.936335532296916 0.301145545567459 0.763303511698657 0.875808564443358 Possible antitoxin VapB36 ? Rv1983 PE_PGRS35 20.4 20 15.5 30.2 9.3 65.3193852613377 0.801067091621419 0.43752121128596 1.83092172666767 0.0671122269190925 0.173006919757952 PE-PGRS family protein PE_PGRS35 IV.C.1.b - PE_PGRS subfamily Rv1984c cfp21 74 54.4 30.7 61.6 15.8 56.4042031859367 0.268660510738183 0.449517388165097 0.597664334709808 0.550063927581246 0.726445351041303 Probable cutinase precursor CFP21 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1985c - 11 9.3 7.7 16.9 5.2 18.5686791060071 1.03924415782173 0.690647800086615 1.50473824385077 0.132391386578925 0.284890820937153 Probable transcriptional regulatory protein (probably LysR-family) I.J.1 - Repressors/activators Rv1986 - 26.6 12.4 10.7 31.2 3.3 16.4239878391533 0.68124679036948 0.775486061285844 0.878477156945794 0.379684828887101 0.579673993068152 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv1987 - 421.1 285.2 201.1 637.2 242.7 330.721884688552 1.35574978716196 0.272569209632723 4.97396528752748 6.55970601250975e-07 1.12243858436278e-05 Possible chitinase II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv1988 erm(37) 134.5 61.4 61.3 151.9 73 113.535466213102 1.25655009581211 0.365124736806915 3.44142691289798 0.000578654771954722 0.00392642759054335 Probable 23S rRNA methyltransferase Erm(37) IV.H - Miscellaneous transferases Rv1989c - 84.8 36.4 33.6 199.1 52.8 96.9329175157869 2.04126242169479 0.378766784891236 5.38923290826818 7.07590551597381e-08 1.44872007731672e-06 Hypothetical protein VI - Unknowns Rv1990c - 66.6 49.8 24.6 193.9 45.7 54.5634590226833 2.09821277263628 0.459845134599586 4.56286826751646 5.04594773634724e-06 7.06432683088613e-05 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv1990A - 19.4 9.1 18 31 8.3 11.2914012951837 0.957770357350489 0.878095467374508 1.09073602237603 0.275389055127996 0.471577094280145 Possible dehydrogenase (fragment) ? Rv1991c mazF6 77.2 46.2 33.1 66.6 10.4 28.1366696105856 0.302378396225378 0.593663557007778 0.509343032187196 0.610511799855219 0.769779720429378 Toxin MazF6 V - Conserved hypotheticals Rv1991A mazE6 130 84.9 46 141.6 37 40.6818530638684 0.788841891256881 0.506219006213386 1.55830160775189 0.119161768027344 0.26511996378948 Antitoxin MazE6 ? Rv1992c ctpG 32.1 12.9 21.3 43.1 14 118.059818208029 1.10597239241836 0.377896789860567 2.9266519909482 0.00342632040546792 0.0168555928835658 Probable metal cation transporter P-type ATPase G CtpG III.A.2 - Cations Rv1993c - 56.7 16.9 31.4 48.2 54.6 28.6051459898589 1.54787457349799 0.674863454611657 2.29361148973269 0.0218128248290528 0.074387773636285 hypothetical protein V - Conserved hypotheticals Rv1994c cmtR 70.9 43.9 43.9 83.1 65.3 52.8385871114327 1.40351437494501 0.502191207986069 2.79478085762095 0.00519349068589279 0.0237665943274319 Metal sensor transcriptional regulator CmtR (ArsR-SmtB family) I.J.1 - Repressors/activators Rv1995 - 1.6 6.4 2.5 4.2 5.1 7.59392443880233 1.45604870518995 1.18178266163972 1.23207824285532 0.217919857908685 0.401180944237299 hypothetical protein VI - Unknowns Rv1996 - 1074.7 410.4 692.4 1897.1 563.5 1875.96689449895 1.47531915389643 0.29775827830308 4.95475444815255 7.24216885490773e-07 1.22735703751594e-05 Universal stress protein family protein V - Conserved hypotheticals Rv1997 ctpF 279 126 229.5 964.1 287.7 2335.0542139912 2.23041694103502 0.313275851301534 7.11965806419021 1.08195143380156e-12 6.28241307954937e-11 Probable metal cation transporter P-type ATPase A CtpF III.A.2 - Cations Rv1998c - 10 1.5 9.2 7.2 4.9 10.9495206506933 0.51662615263598 0.967471929288943 0.533996012696391 0.593344292734003 0.759028225843 hypothetical protein V - Conserved hypotheticals Rv1999c - 1 1.3 3.2 0.6 1.5 3.92067438536797 -0.584581039153925 1.60125527200471 -0.365076730346719 0.715054130375492 NA Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2000 - 5.8 5.3 3.3 6.3 6.1 21.1599188989214 1.30728305723922 0.714717964953615 1.82908940497119 0.0673862159079197 0.173460738914136 hypothetical protein VI - Unknowns Rv2001 - 16.6 11.2 13.6 5.3 2.6 12.6339535072188 -1.27681281264488 0.882873413647781 -1.44620145188136 0.148120706623077 0.307418596604226 hypothetical protein V - Conserved hypotheticals Rv2002 fabG3 23.3 18 15 16.5 0.2 18.4093853247733 -0.561517340162296 0.792468871939504 -0.70856706180525 0.478593182500435 0.667392540321473 Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) I.H.1 - Synthesis of fatty and mycolic acids Rv2003c - 271.2 93.8 191.5 191.7 61.9 266.508233277536 0.167781438066729 0.363586655384059 0.46146203547955 0.644467153004522 0.79647685134055 hypothetical protein V - Conserved hypotheticals Rv2004c - 661.6 291 713.2 1012.6 457.2 2123.887228113 1.17463053498261 0.676304444576736 1.7368369295839 0.0824159585603654 0.202861240598203 hypothetical protein VI - Unknowns Rv2005c - 1267.4 598.6 939.7 2408 755.8 2286.80139223196 1.45899932776938 0.289530269738138 5.03919444792061 4.67495333837844e-07 8.23815160424698e-06 Universal stress protein family protein V - Conserved hypotheticals Rv2006 otsB1 74.4 41.2 59.7 49.8 23.5 400.442397575558 0.137999197504312 0.328153926744275 0.420531909745673 0.674096923565062 0.818249247178702 Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP) III.E - Adaptations and atypical conditions Rv2007c fdxA 5122 2259 3821.2 8724.5 3252.8 3527.79740450145 1.4465383487413 0.300470196848843 4.81424901341882 1.47754473929794e-06 2.3468446038535e-05 Ferredoxin FdxA I.B.6.c - Electron transport Rv2008c - 2 6.6 0.8 4 0 5.61731766636268 0.0497535850653898 1.38952863383063 0.0358060883770562 0.971436978358831 NA hypothetical protein V - Conserved hypotheticals Rv2009 vapB15 785 420.3 327.5 429 108.6 177.926580700377 -0.177778335128878 0.316991106890401 -0.560830670843848 0.574912975939471 0.744821734549478 Antitoxin VapB15 V - Conserved hypotheticals Rv2010 vapC15 587.3 405.9 273.3 262 108 240.418421028014 -0.379510805659852 0.299655070161753 -1.26649218868545 0.205336924272213 0.385428397335549 Toxin VapC15 V - Conserved hypotheticals Rv2011c - 4.9 4.8 2.5 6.1 0 2.33446602551127 0.327149040912755 1.83793352738685 0.17799829865332 0.85872431188296 NA Conserved hypothetical protein, probable transcription repressor VI - Unknowns Rv2012 - 3.9 0 0 6 0 1.42003806212473 1.85816453952222 2.5625172366249 0.725132503682048 0.468370745665292 NA hypothetical protein VI - Unknowns Rv2013 - 0 0 0 0 0 0 NA NA NA NA NA Transposase IV.B.1.c - Others Rv2014 - 0.3 0 0 0 0 0.0246867392782753 0.796308846248315 4.46498467717724 0.178345258454894 0.858451837397389 NA Transposase IV.B.1.c - Others Rv2015c - 66.1 49 32.4 23.5 8.8 79.9530214908234 -0.852539048358139 0.406048113863902 -2.09960105526778 0.0357639498772638 0.108641432646028 hypothetical protein V - Conserved hypotheticals Rv2016 - 51.2 48.6 19.2 26.7 20.2 38.2634330535052 0.0716588426968046 0.573429682438245 0.124965353017843 0.900550979561719 0.950805836117826 Hypothetical protein VI - Unknowns Rv2017 - 16.3 17.6 5.1 10.2 2.7 18.5726867061961 -0.257729162423707 0.742256468552684 -0.347223868491506 0.728423140579 0.853481562663189 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv2018 - 27.4 23.2 14.5 14.1 3.9 20.8974628360501 -0.571102228132188 0.679703658702411 -0.840222383416989 0.400783710537983 0.59973633406233 hypothetical protein V - Conserved hypotheticals Rv2019 - 31.1 12.4 15.6 23.8 3.7 12.2465612387619 0.121199032286406 0.855476142099449 0.141674356913061 0.887337230819781 0.942978839353035 hypothetical protein VI - Unknowns Rv2020c - 23.5 35 6 22.2 2.8 8.12852180549363 -0.231937114272202 1.15874226722939 -0.200162815176126 0.841353247825362 0.91350881138875 hypothetical protein VI - Unknowns Rv2021c - 77.5 56.8 59 93 48.5 44.5444351534108 0.925708690136735 0.503707246640369 1.83779109058096 0.0660931949843496 0.171002261968274 Transcriptional regulatory protein I.J.1 - Repressors/activators Rv2022c - 30.7 30.9 22 70.7 51.6 65.0372324974954 2.09283119016522 0.486110714785599 4.30525624412181 1.66792556905006e-05 0.000201631138756836 hypothetical protein V - Conserved hypotheticals Rv2023c - 31.2 11.3 6 16.2 0 6.34474424442147 -0.174666345202711 1.22696442985133 -0.142356486425507 0.886798431070544 NA Hypothetical protein VI - Unknowns Rv2024c - 55 40.1 21.3 20.2 8 78.8348276344933 -0.673314722096134 0.414596318746683 -1.62402484453203 0.104370506263036 0.240364325867148 hypothetical protein V - Conserved hypotheticals Rv2025c - 10.4 4.6 11.5 6.1 1.3 11.9521176663795 -0.620810816066551 0.91871483479722 -0.675738316779849 0.499206803826735 0.68587684218553 hypothetical protein II.C.5 - Other membrane proteins Rv2026c - 22.5 10.9 11.9 11.2 0 15.6581570601128 -0.742998486809372 0.841167560663959 -0.883294270433945 0.377077298666394 0.577837952376086 Universal stress protein family protein V - Conserved hypotheticals Rv2027c dosT 123.8 97 84.2 90.1 35.1 290.927167074392 0.06013174259164 0.298192404664751 0.201654172443608 0.84018709159171 0.91350881138875 Two component sensor histidine kinase DosT I.J.2 - Two component systems Rv2028c - 593.6 224.7 291.1 316.7 65 437.03667677921 -0.283202921131024 0.314075845458941 -0.901702328357009 0.367215015828548 0.568228740089435 Universal stress protein family protein V - Conserved hypotheticals Rv2029c pfkB 1401.9 661.2 717.2 1240.3 239.9 1586.43808083857 0.285860093434534 0.27772451873303 1.02929368547876 0.303341689664781 0.499819605717656 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) I.B.1 - Glycolysis Rv2030c - 4267.9 1855.7 2472.2 5956 1234.7 12528.4512930406 0.933127391376566 0.282083534816788 3.30798248108536 0.000939706878419486 0.00583937151466986 hypothetical protein V - Conserved hypotheticals Rv2031c hspX 9301.8 4724.7 6561.7 20042.3 9860.9 10619.4377921753 2.00308770818935 0.290088444119014 6.90509308039706 5.01705206467177e-12 2.37207391228455e-10 Heat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3) III.B - Chaperones/Heat shock Rv2032 acg 828.8 376.7 641.4 1334.4 565.7 1677.71327631372 1.43137426971939 0.311638583597066 4.5930585782988 4.36796387566453e-06 6.19167484293567e-05 Conserved protein Acg V - Conserved hypotheticals Rv2033c - 15.8 8.1 3.5 17.8 8.4 19.2238717499366 1.46730588101129 0.715176709892075 2.05166899413254 0.0402018420038779 0.11932226935464 hypothetical protein VI - Unknowns Rv2034 - 17.5 6.5 3.6 30.8 17.6 10.8317882906596 2.25102094743569 0.946123240505456 2.37920479179129 0.0173500338722885 0.0624205113630684 ArsR repressor protein I.J.1 - Repressors/activators Rv2035 - 24.1 26.4 8.6 141.1 20.6 43.160920567018 2.73221101278686 0.558679648480178 4.89047886426418 1.00590959919911e-06 1.64950546313114e-05 hypothetical protein VI - Unknowns Rv2036 - 21.6 20 12 116.8 22.2 52.5759033808991 2.65443863077292 0.485209833391171 5.47070246334628 4.48255297392434e-08 9.62158970108042e-07 hypothetical protein IV.D - Antibiotic production and resistance Rv2037c - 30.3 22 17.5 25.1 2.5 32.4587338989108 -0.0833782375734026 0.588276970829092 -0.141732962036391 0.887290937817767 0.942978839353035 Conserved transmembrane protein II.C.5 - Other membrane proteins Rv2038c - 20.2 18.6 15.3 4.5 5.4 25.7591467197954 -1.32928565777518 0.70974432489134 -1.87290776573478 0.0610811226430836 0.161798318071749 Probable sugar-transport ATP-binding protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2039c - 14.8 4 10.8 5.9 2.5 10.8175030765648 -0.722016143295754 0.952432972038027 -0.758075543889221 0.448405759461243 0.642497249195681 Probable sugar-transport integral membrane protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2040c - 43.3 23 20.9 20 6.6 37.0023734377325 -0.351430901546392 0.52319180347344 -0.671705671253377 0.50177109022722 0.687001624114732 Probable sugar-transport integral membrane protein ABC transporter III.A.3 - Carbohydrates, organic acids and alcohols Rv2041c - 27.1 10 15.9 15.2 4.7 34.8650910916805 -0.0818107398317125 0.556712885579339 -0.146953199666965 0.883168960428717 0.94007980290874 Probable sugar-binding lipoprotein III.A.3 - Carbohydrates, organic acids and alcohols Rv2042c - 52.8 17.5 31.2 51.1 21.9 57.1298866092628 0.887020197964813 0.469913393146683 1.88762484938992 0.0590763316611639 0.158521489957456 hypothetical protein V - Conserved hypotheticals Rv2043c pncA 170.6 100.4 87.3 92.7 30.3 98.8592357180057 -0.205630026772048 0.364458490598137 -0.564206986739627 0.572613273478709 0.743263052300572 Pyrazinamidase/nicotinamidase PncA (PZase) IV.D - Antibiotic production and resistance Rv2044c - 11.2 6.1 9.3 9.9 3 3.29068265377143 -0.064510475534656 1.60076988385969 -0.040299655925005 0.967854228089727 NA hypothetical protein VI - Unknowns Rv2045c lipT 53.8 49.4 44.8 32.9 14.2 116.704518913963 -0.345382162209429 0.390042793322962 -0.885498125133788 0.375888030360046 0.576611261816926 Carboxylesterase LipT II.B.5 - Esterases and lipases Rv2046 lppI 20.9 27.3 5 13 1.4 13.6400664417473 -0.766507015214307 0.95632337072961 -0.80151446537327 0.422833873186614 0.617599001578139 Probable lipoprotein LppI II.C.1 - Lipoproteins(lppA-lpr0) Rv2047c - 54.5 36.9 22.4 2.3 0.8 93.0247225325679 -3.99181797424249 0.502441217692952 -7.94484575244768 1.94432572872944e-15 1.91300048087769e-13 hypothetical protein V - Conserved hypotheticals Rv2048c pks12 77.9 61.9 50.2 8.5 3.8 856.14613886849 -2.58474731801153 0.284807506067243 -9.07541852987987 1.13241442508898e-19 1.74391821463702e-17 Polyketide synthase Pks12 I.I - Polyketide and non-ribosomal peptide synthesis Rv2049c - 68.8 60.8 23 44.4 0 13.9144757869086 -0.522701832027257 0.891463109197208 -0.586341517259158 0.557646036471146 0.732362721980274 hypothetical protein VI - Unknowns Rv2050 - 56.8 12.4 13.5 169.3 55.1 46.8113968453617 2.77459385299088 0.540350159243197 5.13480713483441 2.82433506123827e-07 5.18331336109116e-06 hypothetical protein V - Conserved hypotheticals Rv2051c ppm1 71.6 55.4 37.5 33.2 17.3 216.32635664073 -0.270334485198954 0.327109904657243 -0.826433199820774 0.408558396836531 0.60498070300794 Polyprenol-monophosphomannose synthase Ppm1 II.C.5 - Other membrane proteins Rv2052c - 61 36.1 37.5 20.3 2.5 83.9184444794871 -1.32805651712132 0.45092119659992 -2.94520755984697 0.00322738078445364 0.0161232478681732 hypothetical protein VI - Unknowns Rv2053c fxsA 65.9 27 26.4 42.6 9.9 31.3283100720752 0.146834175280942 0.56912829983657 0.257998372815246 0.796408163031395 0.894413994739489 Probable transmembrane protein FxsA V - Conserved hypotheticals Rv2054 - 45.9 35.4 19.3 17.9 5.2 30.3750549533946 -0.763430898652925 0.585121428380316 -1.3047392585949 0.191981648565486 0.367567026604838 hypothetical protein VI - Unknowns Rv2055c rpsR2 17.3 17.5 10.1 40.6 28.5 15.1473666327946 2.16037342462321 0.799375053860886 2.70257798787798 0.0068804041408604 0.0300498045214889 30S ribosomal protein S18 RpsR2 II.A.1 - Ribosomal protein synthesis and modification Rv2056c rpsN2 2.9 0 4.8 11 15.3 5.73580959623479 3.16735549964609 1.36338383527547 2.32315758607049 0.0201706883453427 NA 30S ribosomal protein S14 RpsN2 II.A.1 - Ribosomal protein synthesis and modification Rv2057c rpmG1 11.1 6.9 0.8 25.2 72.1 15.1447409516527 4.33046065134982 1.07612868860676 4.02411040352094 5.71910848513095e-05 0.00056330656443287 50S ribosomal protein L33 RpmG1 II.A.1 - Ribosomal protein synthesis and modification Rv2058c rpmB2 6.6 8.6 0 43.5 124.8 36.9655603836426 5.69990411297781 1.52874319291017 3.72849026534487 0.000192630348546886 0.00155420659351497 50S ribosomal protein L28 RpmB2 II.A.1 - Ribosomal protein synthesis and modification Rv2059 - 17.1 11 12.3 18.9 22.2 66.2484406719386 1.66174548975891 0.527482073684908 3.15033547614274 0.00163083080187845 0.00930177568478821 hypothetical protein V - Conserved hypotheticals Rv2060 - 20.4 8.6 13.9 12 9.8 10.6769502152248 0.386989749773006 0.927615034532213 0.417187880065097 0.676540989522245 0.820372538475793 Possible conserved integral membrane protein V - Conserved hypotheticals Rv2061c - 133.3 65.7 83.1 89.5 16.6 55.0211571287627 -0.174663005342861 0.479967887708965 -0.363905606636689 0.715928497811497 0.846966846776327 hypothetical protein VI - Unknowns Rv2062c cobN 49.7 35.4 26.3 15.8 3.2 157.434688307509 -1.27744288595387 0.353517435369682 -3.61352159227456 0.000302066187503686 0.00229596230930913 Cobalamin biosynthesis protein CobN I.G.13 - Cobalamin Rv2063 mazE7 44.2 7.4 9.7 15.1 4.2 4.65499095992863 -0.548666223233681 1.44725030148013 -0.379109420583675 0.704606610949462 NA Antitoxin MazE7 ? Rv2063A mazF7 32.7 7.3 8.9 6.8 2.7 6.01482509147207 -1.3230792218768 1.31664174750272 -1.0048893135785 0.314950150745785 NA Possible toxin MazF7 ? Rv2064 cobG 63.3 26.4 23 22.6 7.2 52.5896329160481 -0.555993592877347 0.474097142289768 -1.1727419199197 0.240899315404091 0.428131146593723 Precorrin-3B synthase CobG I.G.13 - Cobalamin Rv2065 cobH 40.8 16.7 17.1 13.3 0 16.7540481243357 -1.12772283834664 0.830626561558144 -1.3576773131733 0.174566098627396 0.344272339275188 Precorrin-8X methylmutase CobH (aka precorrin isomerase) I.G.13 - Cobalamin Rv2066 cobI 50.9 32.8 17.5 14.9 5.2 62.1034897590192 -0.988483306132133 0.455180181842368 -2.17163080811469 0.0298835213052043 0.0945910924602623 Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase I.G.13 - Cobalamin Rv2067c - 84.4 65.8 33.9 56.3 12.9 110.241216333679 -0.101241580386023 0.378501050690187 -0.267480315315932 0.78909936831433 0.890124191901069 hypothetical protein V - Conserved hypotheticals Rv2068c blaC 136.6 85.2 49.5 44.5 17.1 107.166092898167 -0.748695946142818 0.376157374804392 -1.99037954933663 0.046549140965471 0.133072685471912 Class a beta-lactamase BlaC IV.D - Antibiotic production and resistance Rv2069 sigC 147.8 108.4 67 48.6 45.5 92.6708345584926 -0.233324533273742 0.45730827430278 -0.510212796017024 0.609902388452355 0.769779720429378 RNA polymerase sigma factor, ECF subfamily, SigC II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2070c cobK 18.2 4.5 4.5 13.3 0 8.75600144790789 0.221864209855979 1.0724642490954 0.206873292087001 0.836108815141195 0.913196861927262 Precorrin-6X reductase CobK I.G.13 - Cobalamin Rv2071c cobM 12.7 1.9 4.5 4.4 0 4.97223844447743 -0.749498729190395 1.40044600895168 -0.535185736829254 0.59252142815494 NA Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase) I.G.13 - Cobalamin Rv2072c cobL 7.8 3.3 3.2 5.6 0 6.81754186093938 0.0403710897923298 1.15847846392881 0.0348483731457701 0.97220064784283 NA Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL I.G.13 - Cobalamin Rv2073c - 9.1 2.3 0 6.9 0 3.62443474349014 0.732917528210958 1.68298331944217 0.435487101829318 0.663208899200733 NA Probable shortchain dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2074 - 400 225.7 139.7 162.9 50.5 140.384158874239 -0.469747129601295 0.345299855013407 -1.36040349505231 0.173702273085102 0.343592386212569 Possible pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) VI - Unknowns Rv2075c - 23.4 12.6 8.5 7.1 2.6 26.6477440036318 -0.823630381643009 0.61655668703215 -1.33585507864269 0.181596646126312 0.354204893095119 Possible hypothetical exported or envelope protein VI - Unknowns Rv2076c - 122.7 49.5 46 95.8 20.4 29.8496144206565 0.39461909501651 0.578650013034046 0.68196506718698 0.495261039981445 0.683456496189807 hypothetical protein VI - Unknowns Rv2077c - 1001.3 472.3 225 851.2 149.3 919.624547513458 0.514470095085862 0.342475567774595 1.50220962747471 0.133042979225014 0.286119145364298 Possible conserved transmembrane protein V - Conserved hypotheticals Rv2077A - 10.8 5.7 10.7 10.8 0 3.61446778417229 -0.0768951603853031 1.5499551198573 -0.049611217383109 0.96043220746196 NA hypothetical protein ? Rv2078 - 18.3 12 14.2 11.5 12.1 9.44368667019955 0.464622351524784 0.999895324194603 0.464670991335046 0.642167085164995 0.794743471577363 hypothetical protein VI - Unknowns Rv2079 - 20.6 24.8 12.5 8 4.3 51.7682618095251 -0.899768513604754 0.523777029743929 -1.71784645471117 0.0858246256263875 0.208928401353034 hypothetical protein VI - Unknowns Rv2080 lppJ 29.6 38.1 29.5 12 8.2 24.4380242903096 -1.1256724557764 0.698734160109845 -1.61101677868367 0.107176065442962 0.244284185198824 Lipoprotein LppJ II.C.1 - Lipoproteins(lppA-lpr0) Rv2081c - 70.2 26.2 18.9 84.5 18.8 36.5266282967855 1.19115610827574 0.545941264574392 2.18183930317916 0.0291213947460201 0.0926166464002983 Conserved transmembrane protein VI - Unknowns Rv2082 - 43.3 35 30.5 15.3 11.3 114.229640654198 -0.61853931520252 0.418262213377807 -1.47883144931337 0.139185368250088 0.29521584310508 hypothetical protein V - Conserved hypotheticals Rv2083 - 71.3 54 30.7 14.9 3.5 53.2228891148951 -1.80115992029815 0.510503570400704 -3.52820239608586 0.000418392118075453 0.00297579293619127 hypothetical protein V - Conserved hypotheticals Rv2084 - 72.4 52.2 41.9 13.3 8.3 75.8649889428592 -1.61917616057211 0.457703190496935 -3.5376116972533 0.000403763366677995 0.00290676797718183 Hypothetical protein VI - Unknowns Rv2085 - 89.8 35.4 53.5 6.9 0 17.5177335851938 -3.25750712621613 0.929428230894676 -3.50485063605225 0.000456863519313113 0.00321711846005377 hypothetical protein IV.B.1.c - Others Rv2086 - 14.7 16.2 9.1 3.2 0 8.16743989758843 -2.28726740847315 1.16942331226306 -1.95589346003958 0.0504777059151037 0.140892068046728 hypothetical protein IV.B.1.c - Others Rv2087 - 7.4 12.8 0 5.8 0 1.52087704821666 -0.0230108368462584 2.29907556215895 -0.0100087344778917 0.992014318614431 NA hypothetical protein IV.B.1.c - Others Rv2088 pknJ 12 7.2 4.1 9.4 3.1 23.199138444041 0.445263635992805 0.630357686166284 0.706366632412804 0.479960165875996 0.668509204692401 Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2089c pepE 6.2 7.6 1.9 8.1 0 8.49762291613633 0.300150848419161 1.08961601591367 0.275464791298499 0.782959172289718 0.885336132396263 Dipeptidase PepE II.B.3 - Proteins, peptides and glycopeptides Rv2090 - 3.3 7.3 2.7 1.4 0 5.78319677021709 -1.94785019523725 1.36013500141067 -1.43210063208213 0.152115023611875 NA Probable 5'-3' exonuclease II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2091c - 462.1 309.8 285.6 317 185.4 479.138496347688 0.430907067862973 0.305928110289772 1.40852394196408 0.158975982614212 0.324652215937749 Probable membrane protein II.C.5 - Other membrane proteins Rv2092c helY 162.7 123 83.9 32 7.1 368.954913489899 -1.96322750963719 0.303912839567174 -6.45983734163115 1.0481558237523e-10 3.94954034864962e-09 ATP-dependent DNA helicase HelY II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2093c tatC 226.7 140.3 104 121.5 41.5 215.507788565023 -0.166137026225743 0.294819898381737 -0.563520397156593 0.5730805747693 0.743263052300572 Sec-independent protein translocase transmembrane protein TatC II.C.5 - Other membrane proteins Rv2094c tatA 1037.3 629.9 583.2 762.6 355 343.081172456315 0.419643017604333 0.286455009014872 1.46495262571075 0.142933843363064 0.301172916830442 Sec-independent protein translocase membrane-bound protein TatA V - Conserved hypotheticals Rv2095c pafC 113.4 61.3 52.8 42.5 15.5 96.2001800645425 -0.617608540500575 0.374034821039392 -1.65120599944231 0.0986965184974339 0.231279488813622 Proteasome accessory factor C PafC V - Conserved hypotheticals Rv2096c pafB 142.6 71.5 63.2 111 26.1 151.798085288987 0.294429956314359 0.329805383154278 0.892738479579724 0.371997238601415 0.57379582709341 Proteasome accessory factor B PafB V - Conserved hypotheticals Rv2097c pafA 261.2 194.7 151.1 191.9 96.4 496.715924380909 0.37816453297739 0.285640340577291 1.32391850609443 0.185530111376827 0.359097078959956 Proteasome accessory factor a PafA V - Conserved hypotheticals Rv2100 - 9.4 9 6.5 2.5 0 14.5403565859203 -1.97218066504567 0.90948527267876 -2.16845805456189 0.0301238527293209 0.0950968684200131 hypothetical protein V - Conserved hypotheticals Rv2101 helZ 70.4 40.9 30.8 22.7 3.5 168.421470890747 -1.15271803679895 0.35755708411878 -3.22387134250155 0.00126470206226608 0.00760538999074103 Probable helicase HelZ II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2102 - 65.5 44.2 30.5 10.4 2.8 34.9573141133376 -2.15350823535869 0.603109765761832 -3.57067379374705 0.000356064110473405 0.00262199392785197 hypothetical protein V - Conserved hypotheticals Rv2103c vapC37 179.6 136 69.8 90.8 10.5 69.2876724891805 -0.708839565079547 0.486704527010881 -1.456406352809 0.14528032042781 0.304073036187314 Possible toxin VapC37 Contains PIN domain V - Conserved hypotheticals Rv2104c vapB37 300 147.9 133.3 272.6 70.8 88.5400715451538 0.574477607364737 0.378952971686791 1.5159601594035 0.129529426803274 0.280435959497064 Possible antitoxin VapB37 V - Conserved hypotheticals Rv2105 - 13.9 10.5 2.5 5.7 5.5 4.26305614991756 -0.0396012757413708 1.42440454598701 -0.0278019863478672 0.977820081699806 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2106 - 8.1 5.2 4 3.6 0 6.49609957212032 -0.957621222479735 1.20076985962695 -0.797506045644121 0.425157193106278 NA Probable transposase IV.B.1.a - IS6110 Rv2107 PE22 27.1 20.8 11.9 13.7 0 6.77796947800461 -0.809248658818623 1.17816662463141 -0.686871145303232 0.492163931555196 NA PE family protein PE22 IV.C.1.a - PE subfamily Rv2108 PPE36 30.2 21.8 16 14.2 16 30.7491650947041 0.274075697992748 0.630005564355916 0.435036948083067 0.663535608671729 0.811587316217242 PPE family protein PPE36 IV.C.2 - PPE family Rv2109c prcA 455.4 255.6 236.7 305.1 126.6 402.51420712798 0.274287724788531 0.269246095602129 1.01872498531549 0.308333547400408 0.504621382347832 Proteasome alpha subunit PrcA; assembles with beta subunit PrcB II.B.3 - Proteins, peptides and glycopeptides Rv2110c prcB 744.7 416.8 428.2 523.7 161.3 753.799149256937 0.101821492770043 0.249329038980731 0.408382004704684 0.682993242804435 0.823327540999627 Proteasome beta subunit PrcB; assembles with alpha subunit PrcA II.B.3 - Proteins, peptides and glycopeptides Rv2111c pup 1919.1 1155.9 1051.4 1435.9 582.7 475.015868771967 0.372226016970861 0.262770344763751 1.41654499599458 0.156615999790784 0.321212432691927 Prokaryotic ubiquitin-like protein Pup V - Conserved hypotheticals Rv2112c dop 201.7 148.1 112.7 50.2 21.3 312.944382359344 -1.32414369377465 0.297880798527711 -4.44521332129929 8.78046972018266e-06 0.000115614958174301 Deamidase of pup Dop V - Conserved hypotheticals Rv2113 - 18.1 13 9.9 5.5 3.2 21.529572847683 -0.962374867446711 0.690594625814772 -1.39354526008842 0.163454968491009 0.330078391331331 Probable integral membrane protein II.C.5 - Other membrane proteins Rv2114 - 40.8 23.6 23.9 31.7 3.3 25.5222878301387 -0.162399563495596 0.662562493007185 -0.245108295760164 0.80637257973265 0.898167194155046 hypothetical protein VI - Unknowns Rv2115c mpa 569.5 425.2 300.5 548.1 196.7 1494.09042216974 0.567907071939893 0.236610262378524 2.40017937612261 0.0163870394903117 0.0595311732048041 Mycobacterial proteasome ATPase Mpa III.C - Cell division Rv2116 lppK 11.2 15.1 2.9 7.7 7.8 10.2550902299788 0.482721603452819 0.997892821989066 0.483740931707101 0.628569740233955 0.784029780449398 Conserved lipoprotein LppK II.C.1 - Lipoproteins(lppA-lpr0) Rv2117 - 2.2 3.1 5 4.3 0 1.12601347272427 0.606999197426094 2.58980723027734 0.234380069037451 0.814689930363898 NA hypothetical protein V - Conserved hypotheticals Rv2118c - 27.8 15 5.1 15.6 0.2 15.7787771541399 -0.316938481923957 0.877615415421958 -0.36113595585781 0.717997815535393 0.84828160861453 RNA methyltransferase V - Conserved hypotheticals Rv2119 - 20.3 12.8 8.1 4.7 0 11.6385407910483 -1.67156457133358 0.971206580003482 -1.72112154689848 0.0852287701169873 0.207763457504727 hypothetical protein V - Conserved hypotheticals Rv2120c - 39.1 27.3 16.6 17 23.2 26.4404845313139 0.53857376214552 0.689402579641361 0.781218083671366 0.434674239539903 0.62995751082256 Probable conserved integral membrane protein VI - Unknowns Rv2121c hisG 8 1.8 5 3 5.8 9.58063966287312 0.87176813716179 1.07309420157944 0.812387333636385 0.416569411955922 0.612100983924352 ATP phosphoribosyltransferase HisG I.D.5 - Histidine Rv2122c hisE 1.6 6.8 0 10.8 0 1.49787640793076 2.31147499262218 2.36079133339256 0.979110249994221 0.327525507624606 NA Phosphoribosyl-AMP pyrophosphatase HisE I.D.5 - Histidine Rv2123 PPE37 0.7 0 0.4 0.6 0.3 0.453756472644283 1.25116270456649 3.99090223965305 0.31350372157331 0.75389799369728 NA PPE family protein PPE37 IV.C.2 - PPE family Rv2124c metH 159.9 110.9 94.3 163.3 51.4 821.508613979557 0.544242182575733 0.243108613766531 2.2386791407498 0.0251768007130164 0.0829826395087893 5-methyltetrahydrofolate--homocystein methyltransferase MetH (methionine synthase, vitamin-B12 dependent isozyme) (ms) I.D.2 - Aspartate family Rv2125 - 151.4 56.4 63.3 96.4 25.3 123.781737803569 0.17975788072069 0.365909200006247 0.491263626926082 0.623240002165197 0.780875094382658 hypothetical protein V - Conserved hypotheticals Rv2126c PE_PGRS37 8.3 3.8 2.3 0.2 0 2.70609134617685 -3.82383861904153 2.00385060455216 -1.9082453603851 0.0563595113953592 NA PE-PGRS family protein PE_PGRS37 IV.C.1.b - PE_PGRS subfamily Rv2127 ansP1 166 103.1 74.5 117.8 27.8 260.396874355383 0.0503694001870049 0.293243766818287 0.171766311466791 0.863621251395932 0.927234456636675 L-asparagine permease AnsP1 III.A.1 - Amino acids Rv2128 - 264.9 160.2 164.6 244 90.9 74.911985483597 0.512093212941432 0.401198595157749 1.27640829036323 0.201811227136356 0.380625860765161 Conserved transmembrane protein VI - Unknowns Rv2129c - 68.3 35.2 30.9 40.9 10.6 57.8712293421452 -0.0884391041569658 0.443130118207506 -0.199578183750426 0.841810491353157 0.91350881138875 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2130c mshC 183.4 108.3 101.4 76 36.9 236.345440125282 -0.39219307849727 0.310099674498377 -1.26473231270458 0.205967302600728 0.385997981910995 Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC II.A.3 - Aminoacyl tRNA synthases and their modification Rv2131c cysQ 360.5 218.9 172.3 146.8 50.2 272.953291684359 -0.569282480407065 0.282466781112331 -2.01539621107047 0.0438631511248114 0.127346951872198 Monophosphatase CysQ I.C.5 - Sulphur metabolism Rv2132 - 128 83.9 76.5 150.3 53.2 45.9001178260283 0.848992757017396 0.472074178097633 1.79843083228714 0.0721087604486471 0.182045067362158 hypothetical protein V - Conserved hypotheticals Rv2133c - 103.7 35 45.1 86.5 11.1 76.0321628582431 0.315248686530759 0.464591645043278 0.678550055503888 0.497422997620316 0.684221070039329 hypothetical protein V - Conserved hypotheticals Rv2134c - 323.4 192.1 185.1 170.5 59.3 202.748264263692 -0.274026051610649 0.304676579401024 -0.899399790260767 0.368439750878685 0.569874933455154 hypothetical protein V - Conserved hypotheticals Rv2135c - 224 134.4 105.8 72.6 18.4 134.585470856588 -1.0163580887701 0.345856549404202 -2.93866948745356 0.00329624376926655 0.0164209499729144 hypothetical protein V - Conserved hypotheticals Rv2136c - 285.9 191.3 139.9 338.7 56.8 308.788859795298 0.538731859847973 0.317194840775354 1.69842566963287 0.089427450658964 0.215038717063171 Possible conserved transmembrane protein III.A.6 - Efflux proteins Rv2137c - 2017.4 1205.9 600.5 5394.4 438.9 1448.6786041769 1.64145328422692 0.695783759725586 2.35914285334038 0.0183172030131793 0.0652055608770666 hypothetical protein V - Conserved hypotheticals Rv2138 lppL 165.3 103.2 59 137.3 32.4 195.610997076332 0.368828843977289 0.323570336245422 1.13987224001133 0.254339531803577 0.446230525505971 Probable conserved lipoprotein LppL II.C.1 - Lipoproteins(lppA-lpr0) Rv2139 pyrD 84.8 57.9 53.4 40.6 8.7 91.906059698463 -0.753388167727314 0.402813708423351 -1.8703141228141 0.0614402094944619 0.162216617313321 Probable dihydroorotate dehydrogenase PyrD I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv2140c TB18.6 18.2 4.4 2.7 19.6 7.2 10.8620516863274 1.5171154939102 0.94030652773054 1.61342652546698 0.106651874161646 0.243560477924416 Conserved protein TB18.6 V - Conserved hypotheticals Rv2141c - 30.1 19 12.4 19.5 5.3 42.0676447319115 0.0517694507739783 0.493622344131419 0.104876635730646 0.916473698695168 0.959264137345829 hypothetical protein I.D.2 - Aspartate family Rv2142c parE2 91 24.9 52 136.6 41.1 45.3684190177817 1.42102819583813 0.512468770410584 2.77290691235608 0.00555580108886072 0.0251323722308361 Possible toxin ParE2 VI - Unknowns Rv2142A parD2 213 97.2 75.9 318.7 49.6 60.2088378032904 1.20322917439782 0.46255608979901 2.60126112472251 0.00928817252592298 0.037342459803427 Possible antitoxin ParD2 ? Rv2143 - 34.8 22 17.6 25.5 5.6 40.3566345267529 0.0606359539447687 0.50432065902716 0.120232936841683 0.904298627192237 0.952431084601517 hypothetical protein V - Conserved hypotheticals Rv2144c - 479.2 289.7 266.8 600 294.9 306.563606828457 1.24915639535067 0.296693627852054 4.2102569050575 2.55080460843099e-05 0.000289581728303288 Probable transmembrane protein II.C.5 - Other membrane proteins Rv2145c wag31 633 408.5 331.6 580.3 241.9 703.647715182052 0.681286204342282 0.251475134204996 2.70915932303237 0.00674539393414522 0.0295695362806217 Diviva family protein Wag31 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2146c - 201.4 96.5 119.7 350.5 108.3 107.389126695321 1.44222772554206 0.361925448089722 3.98487515358281 6.7515613305946e-05 0.000644583025147334 Possible conserved transmembrane protein VI - Unknowns Rv2147c - 296.6 178.1 130.8 131.9 49.6 207.564473594956 -0.354089628485831 0.301628854017948 -1.1739249205408 0.240425099647505 0.427502862927441 hypothetical protein VI - Unknowns Rv2148c - 141.2 93.1 77.3 62.6 15.6 106.008448319083 -0.689583942572501 0.368864818682482 -1.86947604554853 0.0615566132974024 0.162216617313321 hypothetical protein V - Conserved hypotheticals Rv2149c yfiH 163.8 74 70.1 95.2 5.3 98.8643049319334 -0.469838837131441 0.482274328091595 -0.974214901694307 0.329949847171353 0.530255153666485 Conserved protein YfiH V - Conserved hypotheticals Rv2150c ftsZ 308.4 164.9 138.4 152.7 48.8 335.343712012649 -0.234785577521336 0.270507452342948 -0.867944951193714 0.385424469253809 0.586162932630739 Cell division protein FtsZ III.C - Cell division Rv2151c ftsQ 123.9 80.1 73.9 26 6.2 98.5924663038564 -1.78791732620543 0.401361515066102 -4.45463069848879 8.40377226657135e-06 0.000111706804810264 Possible cell division protein FtsQ III.C - Cell division Rv2152c murC 125.3 88.5 68 31.8 8.1 161.675023332551 -1.51233313100685 0.340958521776073 -4.43553404422631 9.1844314977472e-06 0.00012004153640229 Probable UDP-N-acetylmuramate-alanine ligase MurC II.C.3 - Murein sacculus and peptidoglycan Rv2153c murG 79.6 24.3 19.9 30 7.7 66.1515451535629 -0.293453620917714 0.474512616105682 -0.618431651672581 0.536290838919203 0.715922152695141 Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG II.C.3 - Murein sacculus and peptidoglycan Rv2154c ftsW 160.3 78.9 72.6 79.5 11.4 213.275357796933 -0.55162105822609 0.350378657229615 -1.57435690457765 0.115404960994479 0.259039525882412 FtsW-like protein FtsW III.C - Cell division Rv2155c murD 133.1 68 59.7 56 7.3 156.761957307795 -0.796013130750225 0.374668231619408 -2.12458133242218 0.0336215628882093 0.10319547292031 Probable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD II.C.3 - Murein sacculus and peptidoglycan Rv2156c murX 139.4 84 56.8 118.6 13.2 152.476996705976 0.093888525313991 0.391652180238336 0.23972425037148 0.810544033950762 0.900180115344522 Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX II.C.3 - Murein sacculus and peptidoglycan Rv2157c murF 93.7 52.1 50.6 68.6 16.1 156.733012705247 0.0548397462649867 0.330566778071972 0.165896121155426 0.868238700067734 0.931345086505122 Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF II.C.3 - Murein sacculus and peptidoglycan Rv2158c murE 242.5 121.6 113.1 278.3 87.3 544.510201622076 0.971128135102184 0.25085633338553 3.87125221036258 0.000108277688963434 0.000970443516359783 Probable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE II.C.3 - Murein sacculus and peptidoglycan Rv2159c - 386.1 202.4 204 571 217.6 707.87423466458 1.39418644891201 0.25093691358755 5.5559241124785 2.7614683514158e-08 6.3104005811063e-07 hypothetical protein VI - Unknowns Rv2160A - 813.2 473.2 390.4 1471.1 396.3 932.494821024327 1.45653718901165 0.236993593338813 6.14589267368651 7.95150382363755e-10 2.4705461880109e-08 hypothetical protein ? Rv2160c - 1132.6 713.7 582.9 1997.6 619.5 730.012719666602 1.44126962495006 0.237936271366762 6.0573766944866 1.38359324677232e-09 4.11822460509878e-08 hypothetical protein VI - Unknowns Rv2161c - 720.1 358.3 277.1 1130.8 198 883.592258694579 1.18224650678402 0.291843136599553 4.05096559939397 5.10067067897532e-05 0.000509045105803316 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2162c PE_PGRS38 237 102.1 143.8 202.7 80 495.689021338668 0.624128416470188 0.296256071760576 2.10671940919607 0.0351419087687105 0.107027206241421 PE-PGRS family protein PE_PGRS38 IV.C.1.b - PE_PGRS subfamily Rv2163c pbpB 62.8 36.3 29.1 41.2 16.7 146.091792612933 0.240709189102432 0.325786681984891 0.738855215430802 0.459994919226817 0.652503806127907 Probable penicillin-binding membrane protein PbpB II.C.3 - Murein sacculus and peptidoglycan Rv2164c - 61.3 28 29.5 27.7 6.8 60.9370974520193 -0.487645114342587 0.447007927349241 -1.09090932063403 0.275312785428052 0.471577094280145 Probable conserved proline rich membrane protein VI - Unknowns Rv2165c - 51.1 25.2 29.8 42.1 14.5 75.3867344392338 0.413524883912709 0.402769142645267 1.02670448186969 0.304559638238851 0.500580157142463 hypothetical protein V - Conserved hypotheticals Rv2166c - 354.3 212.8 196.5 378.9 196.4 252.448265688374 1.06165067177214 0.309854129027954 3.42629183320118 0.000611882577234634 0.004104712288949 hypothetical protein V - Conserved hypotheticals Rv2167c - 4.6 2.2 4.2 5.1 2 6.43813680000747 0.485307921523493 1.13054303500771 0.429269746038624 0.66772693114926 NA Probable transposase IV.B.1.a - IS6110 Rv2168c - 10.2 10.4 2.1 20.9 9.6 7.01695775409059 1.78537446852783 1.10267128409294 1.6191357245659 0.105418063781954 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2169c - 205.7 126.5 62 318.8 105.7 139.015686144898 1.51601317155319 0.348571616952059 4.34921576463781 1.36625238733088e-05 0.000169798805471086 Probable conserved transmembrane protein VI - Unknowns Rv2170 - 10.9 9.5 2.3 5.6 0 5.09828115473205 -0.575116678537069 1.3502523687008 -0.425932730701626 0.670156864075206 NA GCN5-related N-acetyltransferase VI - Unknowns Rv2171 lppM 27.4 21.6 11 27.2 5.2 22.7952034958225 0.464777410804438 0.645184037612409 0.720379587387825 0.471291314586814 0.661900807401465 Probable conserved lipoprotein LppM II.C.1 - Lipoproteins(lppA-lpr0) Rv2172c - 355.6 279.1 155.1 244.1 53.1 352.261739027196 -0.158380586503793 0.304125684664101 -0.520773464690168 0.602524590238427 0.765199748520799 hypothetical protein VI - Unknowns Rv2173 idsA2 63 32.5 22.8 27.1 5.6 53.7899061465564 -0.493273736806462 0.470435708562877 -1.04854654488996 0.294386869434898 0.489999197151507 Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv2174 mptA 43.4 29 21.7 15.9 3.8 60.6034647117754 -0.910030573672619 0.446631067083684 -2.03754427477412 0.0415955298335523 0.122064098318511 Alpha(1->6)mannosyltransferase Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2175c - 36.6 11.9 18.7 33.6 28.2 26.8281632352159 1.38228601945101 0.648200006751131 2.13249923643046 0.0329658271934878 0.101834257129666 Conserved regulatory protein I.J.1 - Repressors/activators Rv2176 pknL 26 21.8 14.2 38.6 12.8 56.4930715834574 1.09336309409575 0.441819804417374 2.4746810422805 0.013335521285675 0.0502493791424053 Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2177c - 25.1 10.1 13 20.2 7.2 19.4568847351406 0.566171841663134 0.682648546016333 0.829375298558957 0.406892074516919 0.604819932769508 Possible transposase IV.B.1.c - Others Rv2178c aroG 337 195.8 125.2 228.1 72.4 495.622099461557 0.249066037107824 0.263100065868091 0.946658969035364 0.343812584787377 0.54487031010848 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phenylalanine-repressible) I.D.4 - Aromatic amino acid family Rv2179c - 9.7 14.9 16.7 8.5 0 8.84814289737529 -1.11756014300211 1.12558480456509 -0.992870673510844 0.320772983068094 0.51975201556596 hypothetical protein VI - Unknowns Rv2180c - 12.2 4.6 6.6 10.2 2.2 10.8594336607599 0.257021248572401 0.898623165675427 0.286016718007951 0.774865317079291 0.881423631580758 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2181 - 91.6 54.7 47.7 81.4 21.5 143.901100930735 0.392593535786628 0.326361182559606 1.20294188392005 0.22899881079273 0.412990726999923 Alpha(1->2)mannosyltransferase II.C.5 - Other membrane proteins Rv2182c - 242.6 122.4 121.7 257.7 93.2 253.875438170273 0.905359027121683 0.286266433519169 3.16264472921886 0.00156343000159324 0.00896062955605706 1-acylglycerol-3-phosphate O-acyltransferase V - Conserved hypotheticals Rv2183c - 112 47.6 59.1 45.8 31.4 45.8657290074784 -0.0932693823055211 0.519440083882306 -0.179557537432275 0.857499942995581 0.922892463527786 hypothetical protein VI - Unknowns Rv2184c - 49.1 24.5 26.4 36.9 20.3 74.5201703801079 0.616093959432429 0.419977327772595 1.46696956880974 0.142384333787514 0.30037243018188 hypothetical protein V - Conserved hypotheticals Rv2185c TB16.3 126.2 40 92 248.9 104.2 122.49066042273 1.82967924961569 0.409684355315162 4.46607058794851 7.96693330080726e-06 0.000106632100275827 Conserved protein TB16.3 V - Conserved hypotheticals Rv2186c - 91.8 74.3 38 69.9 13.2 39.445571551183 -0.0101335881689969 0.531145909649906 -0.0190787276808293 0.984778301193579 0.995391798001726 hypothetical protein V - Conserved hypotheticals Rv2187 fadD15 55.3 33.9 29.4 110.4 55 243.830310669435 1.94575690280128 0.308628012543568 6.30453757831397 2.89055588705534e-10 9.75080852566667e-09 Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2188c pimB 15 7.4 10.9 17.2 5.1 25.5681975165229 0.741599276661553 0.610514246295841 1.21471248404282 0.224475769422044 0.408578199019979 Mannosyltransferase PimB V - Conserved hypotheticals Rv2189c - 91.5 55.9 38.3 13.3 2 48.6849305793064 -2.22623170943531 0.545635901599323 -4.0800682339816 4.5022482936999e-05 0.000462230824819856 hypothetical protein VI - Unknowns Rv2190c - 403.5 283.1 188.9 143.5 36.8 420.851336698298 -0.974555831540439 0.276144565648692 -3.5291508607135 0.000416895400842547 0.00297111370177928 hypothetical protein IV.A - Virulence Rv2191 - 9.9 4.9 6 2.9 0.4 14.3456198828921 -1.45550513158198 0.887488966059822 -1.64002617186778 0.100999725352908 0.234430555176933 hypothetical protein II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2192c trpD 79.9 46.4 49.5 29.6 8.9 84.0791028734869 -0.895478597303123 0.403032681371497 -2.22185107732668 0.0262933715590598 0.0859143192455625 Probable anthranilate phosphoribosyltransferase TrpD I.D.4 - Aromatic amino acid family Rv2193 ctaE 1293.5 852.8 619 1045.1 251.3 919.409462100453 0.170333281494272 0.248935116096493 0.684247703438702 0.493818764025966 0.682178651396245 Probable cytochrome C oxidase (subunit III) CtaE I.B.6.a - aerobic Rv2194 qcrC 1395.7 951.3 756.5 1007.9 406.7 1498.4771005862 0.271677543415297 0.238350094140025 1.13982561825922 0.254358958497051 0.446230525505971 Probable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) I.B.6.a - aerobic Rv2195 qcrA 1245.1 776.6 652.8 1162.1 451.6 2243.52827846049 0.67723167979478 0.22829228003249 2.96651152504325 0.0030119907214712 0.0153541524983732 Probable rieske iron-sulfur protein QcrA I.B.6.a - aerobic Rv2196 qcrB 1275.4 637.9 621.4 1088.7 252.6 2373.95968047097 0.335918319817383 0.246271833238064 1.36401437143914 0.172563042587266 0.342035980326859 Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) I.B.6.a - aerobic Rv2197c - 118.9 69.9 57.6 68.6 21 78.6542459828445 -0.117496696964751 0.391610549197313 -0.300034555263092 0.764150797846114 0.876096305656509 Probable conserved transmembrane protein VI - Unknowns Rv2198c mmpS3 207.2 141.5 108.8 174.1 70.9 253.052519370487 0.482927856759678 0.289250767623623 1.66958193655711 0.0950021067301117 0.225685755894068 Probable conserved membrane protein MmpS3 II.C.4 - Conserved membrane proteins Rv2199c - 600.7 330.4 193.4 405.3 69.8 231.076338064989 0.01620820912754 0.344851007066989 0.047000614164921 0.962512738038398 0.984610856411041 Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2200c ctaC 778.4 675.2 437.4 414.2 214.2 1075.25031079318 -0.117360828889395 0.286045968001228 -0.410286604315608 0.681595717484917 0.821999329700911 Probable transmembrane cytochrome C oxidase (subunit II) CtaC I.B.6.a - aerobic Rv2201 asnB 24.7 13.2 10.8 28.5 4 56.4951964418467 0.631617486636456 0.474430764560492 1.33131646136308 0.183084903986028 0.355926293098279 Probable asparagine synthetase AsnB I.D.2 - Aspartate family Rv2202c adoK 369.6 208.1 177.2 187.7 49.1 343.587855553714 -0.364467110056558 0.274120167178086 -1.3295888216053 0.183653783170291 0.356439287665299 Adenosine kinase I.A.1 - Carbon compounds Rv2203 - 17.1 11.8 7.5 18 9.1 18.1959930593683 0.995311667225178 0.70087394753832 1.42010081944266 0.155578331765145 0.319639472802869 Possible conserved membrane protein VI - Unknowns Rv2204c - 2572.4 1971.3 1509.5 3408.1 2631.3 2142.53476778469 1.64336359411332 0.326619170920087 5.03143642635539 4.86818541693172e-07 8.53619442909513e-06 hypothetical protein V - Conserved hypotheticals Rv2205c - 39.5 19.1 12.1 52.1 15 58.3583043051892 1.29667186045289 0.447121295414001 2.90004496263652 0.00373109135256187 0.0180786943512642 hypothetical protein V - Conserved hypotheticals Rv2206 - 185.2 125.9 84.4 91.8 24 128.060987966855 -0.452978055928308 0.346848672746717 -1.30598180567089 0.191558744956396 0.366955692068986 Probable conserved transmembrane protein VI - Unknowns Rv2207 cobT 100.6 56.5 49.4 24.4 1.2 79.9724874089435 -1.73121774837293 0.494555125981561 -3.50055566593697 0.000464289260502391 0.00325002482351673 Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT I.G.13 - Cobalamin Rv2208 cobS 56.6 21.8 21.5 11.3 0 24.8430346893313 -1.74532110127103 0.741650233725018 -2.35329407570597 0.0186079113181087 0.065909221888741 Probable cobalamin 5'-phosphate synthase CobS I.G.13 - Cobalamin Rv2209 - 32.4 18.6 12.3 38.5 3.9 56.2921847213203 0.649392010591612 0.49530767525759 1.31108812366756 0.189827992707071 0.365022122784171 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv2210c ilvE 134.8 89.1 81.9 84.6 25.7 171.585471642984 -0.159314321193152 0.317761274129363 -0.50136481114528 0.616114400209632 0.774585649747932 Branched-chain amino acid transaminase IlvE I.D.7 - Branched amino acid family Rv2211c gcvT 45.5 43.1 19.1 38.2 15.2 71.533314283773 0.372488926427728 0.432843096143952 0.86056339986961 0.389478551177334 0.590178950919345 Probable aminomethyltransferase GcvT (glycine cleavage system T protein) I.C.1 - General Rv2212 - 40.7 28.6 19.5 23.7 10.1 52.3557566459774 -0.0415998238705416 0.457452863036748 -0.0909379462495566 0.927541898346655 0.966205043211274 Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase) V - Conserved hypotheticals Rv2213 pepB 54.1 31.2 29 27.7 11.1 88.1244452490197 -0.202343961385942 0.382393532344951 -0.529151108140111 0.596700629954193 0.761090484565671 Probable aminopeptidase PepB II.B.3 - Proteins, peptides and glycopeptides Rv2214c ephD 171.1 135 95.2 57.7 20.9 303.809575042413 -1.01773586249279 0.294003082614472 -3.46165031142667 0.000536874228308179 0.00368528782299917 Possible short-chain dehydrogenase EphD III.F - Detoxification Rv2215 dlaT 355.7 215.3 166.6 174.7 96 654.504310800336 0.0794834930340545 0.282735802853647 0.281122844124547 0.778616180332588 0.883079894568692 DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase I.B.3 - TCA cycle Rv2216 - 236.6 127.8 106.9 138.1 46.1 219.705345950049 0.016146592961259 0.29297707056762 0.0551121387416983 0.956049125526162 0.980690994096051 hypothetical protein V - Conserved hypotheticals Rv2217 lipB 201.7 160.5 102.4 165.8 47.3 176.70196022072 0.180053279070749 0.319312585808625 0.563877802106619 0.572837298001102 0.743263052300572 Probable lipoate biosynthesis protein B LipB I.G.3 - Lipoate Rv2218 lipA 214.3 95.2 100.5 138.3 68.9 232.332268009795 0.491136528715849 0.318924505535469 1.5399773933685 0.123565864000681 0.270822796290229 Probable lipoate biosynthesis protein A LipA I.G.3 - Lipoate Rv2219 - 274.6 126 135.2 137 34.3 187.090848200473 -0.344739622831052 0.324418712601495 -1.06263791033077 0.287946188002555 0.484333844499261 Probable conserved transmembrane protein VI - Unknowns Rv2219A - 38.5 15.5 19.2 20.8 4.7 13.4849271432498 -0.313301002754754 0.827737461397608 -0.378502867594944 0.705057063920802 0.838305512053535 Probable conserved membrane protein ? Rv2220 glnA1 344.5 244.6 191.7 277.7 168.4 759.473787827116 0.737905163354413 0.297630010909983 2.47927002085011 0.0131651598953975 0.0497798835953653 Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) I.D.1 - Glutamate family Rv2221c glnE 69.5 43.7 31.5 47.5 11.6 220.36480595458 0.0128963326869447 0.300507658908681 0.0429151547543875 0.965769168133162 0.985197300737007 Glutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase) I.D.1 - Glutamate family Rv2222c glnA2 703.9 444.6 307.8 221.3 63.1 798.453877281966 -1.02703001556253 0.247870290377954 -4.14341716385818 3.42168700420891e-05 0.000367261071785089 Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) I.D.1 - Glutamate family Rv2223c - 109.9 53 39.1 54 10.8 141.780594295359 -0.320900707922901 0.357893673105953 -0.896636995949073 0.369912650026527 0.571653842231221 Probable exported protease II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2224c caeA 178 122.2 88.7 97.2 36.9 305.578044916213 -0.164383694603517 0.278961985008004 -0.589269160092909 0.555680729483003 0.730594336981736 Probable carboxylesterase CaeA II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2225 panB 45.2 13.4 22.8 26.4 11.5 39.0798013848362 0.265881669567064 0.538775368505824 0.493492622545883 0.621664551337742 0.779446315340985 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB I.G.5 - Pantothenate Rv2226 - 27.9 14.5 17.2 20 6.4 49.9875950325749 0.142157184387322 0.468265928384985 0.303582165112059 0.761446240861683 0.875802258232129 hypothetical protein VI - Unknowns Rv2227 - 11.4 7.4 7.5 5 5.6 10.9486309069288 0.00175396739872005 0.939029087054231 0.00186785204303129 0.998509670559596 0.999585202738999 hypothetical protein VI - Unknowns Rv2228c - 71 32.1 33 37.6 4.5 65.0650412535645 -0.435334116568202 0.470335167287766 -0.925582747891465 0.354662862466982 0.554445977368376 Multifunctional protein Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities VI - Unknowns Rv2229c - 64 48.4 38.1 46 14.8 58.6569118955708 0.018680392291223 0.438310029702576 0.0426191303536881 0.966005145527844 0.985197300737007 hypothetical protein VI - Unknowns Rv2230c - 33.2 22 15.2 11.8 4.5 34.6755784042726 -0.798808957918562 0.548064143475061 -1.45750997840075 0.144975658969439 0.304073036187314 hypothetical protein V - Conserved hypotheticals Rv2231c cobC 20.4 19 9.3 9 2.5 22.5884160990744 -0.76017073704871 0.673236539797125 -1.12912875655528 0.258843522018754 0.452529000488859 Possible aminotransferase CobC I.G.13 - Cobalamin Rv2231A vapC16 0.9 0 2.5 3.4 0 0.788902238016339 1.46518310232927 2.96862135192507 0.49355674861637 0.62161925272824 NA Possible toxin VapC16 ? Rv2231B vapB16 11 9 10.2 14.1 0 2.22343782523904 0.405995466021213 1.86197531217094 0.218045568793203 0.827393606735647 NA Possible antitoxin VapB16 ? Rv2232 ptkA 36.9 16.2 25.2 16.8 2.3 28.0006903784285 -0.838233203316612 0.65978072352496 -1.27047240610221 0.203916405943673 0.383575098169139 Protein tyrosine kinase transcriptional regulatory protein PtkA VI - Unknowns Rv2234 ptpA 42.4 27.7 40.8 27.8 16 30.7034586222929 -0.0844218756788348 0.608761790326238 -0.138678013338506 0.889704593011471 0.943363751032937 Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2235 - 131.3 68.6 62.1 73.1 26.1 109.720839358464 -0.0266795873788219 0.353790133644978 -0.0754107727763667 0.939887888181276 0.973416052613473 Probable conserved transmembrane protein VI - Unknowns Rv2236c cobD 10.1 3.7 5.3 3.5 0 6.27118565179258 -1.05972231901461 1.23629456435759 -0.857176234181104 0.391347494741432 NA Probable cobalamin biosynthesis transmembrane protein CobD I.G.13 - Cobalamin Rv2237 - 40.9 30.2 16.3 18.1 8.8 31.6815674283565 -0.367827286823908 0.571024370814787 -0.644153394537365 0.519475969122144 0.702015979637785 hypothetical protein V - Conserved hypotheticals Rv2237A - 277.2 187.5 161.4 305.1 106.4 99.1472119355271 0.743673959938837 0.361690897766271 2.05610360816823 0.0397725305395377 0.118481331514754 hypothetical protein ? Rv2238c ahpE 365.7 270 194.2 119.2 21.7 150.807128527419 -1.29213140774958 0.364109130523134 -3.54874761281903 0.000387067885190264 0.00280366963056016 Probable peroxiredoxin AhpE III.F - Detoxification Rv2239c - 415.6 283.5 287.6 140.6 59.3 205.706534070059 -0.983981287351753 0.329176830926091 -2.98921793670431 0.0027969255527123 0.0145259681931187 hypothetical protein VI - Unknowns Rv2240c - 78.2 48.7 41.8 43.4 17.2 50.2055137443302 -0.14438232707375 0.462695233138189 -0.312046281727369 0.755005350407182 0.872220792936151 hypothetical protein V - Conserved hypotheticals Rv2241 aceE 320.6 174.7 160.6 121 47.5 805.400714985999 -0.553808419596893 0.247722977223038 -2.23559568759046 0.0253782673375292 0.0833857355375958 Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase) I.B.2 - Pyruvate dehydrogenase Rv2242 - 126.2 48.4 68.1 63.2 15.5 141.308798265596 -0.326697582000708 0.366323628765303 -0.891827761976055 0.372485258861085 0.574126539114866 hypothetical protein VI - Unknowns Rv2243 fabD 200.5 97 69.3 323.1 172.8 372.030004074702 2.00595346170196 0.310726445039452 6.45568954212207 1.07727253775909e-10 3.97468680077363e-09 Malonyl CoA-acyl carrier protein transacylase FabD (malonyl CoA:ACPM acyltransferase) (MCT) I.H.1 - Synthesis of fatty and mycolic acids Rv2244 acpM 832.2 433.8 311.3 1916.9 686.2 657.535431054265 2.14968180239648 0.254424728537367 8.44918579555745 2.93341330632991e-17 3.46338331034018e-15 Meromycolate extension acyl carrier protein AcpM I.H.1 - Synthesis of fatty and mycolic acids Rv2245 kasA 858.3 287.6 383.9 1160.7 345.9 1554.25632737021 1.34769815113618 0.281147887547444 4.79355602808416 1.63850670835569e-06 2.57937367155372e-05 3-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I) I.H.1 - Synthesis of fatty and mycolic acids Rv2246 kasB 618 211.7 297.7 689.8 254.2 1133.93993055208 1.17473833744432 0.287174153918438 4.09068267953517 4.30105274424484e-05 0.000446754510853818 3-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I) I.H.1 - Synthesis of fatty and mycolic acids Rv2247 accD6 665.9 223.6 315.7 474.8 122.1 943.593458175623 0.2983769629297 0.29621104215963 1.00731208652547 0.313784823353372 0.511458794763375 Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 I.H.1 - Synthesis of fatty and mycolic acids Rv2248 - 193.8 81.8 77.6 107.7 49.2 159.496083669805 0.278357800116234 0.339290909666332 0.82041042711689 0.411982173244015 0.608270470041809 hypothetical protein V - Conserved hypotheticals Rv2249c glpD1 3.3 1.1 0 3.7 1.3 4.74201404004159 1.5470841761127 1.41588675039296 1.09266096012505 0.274542686676128 NA Probable glycerol-3-phosphate dehydrogenase GlpD1 I.B.6.a - aerobic Rv2250c - 2 0 0 1.1 0 0.417709098394807 0.771261012707335 4.13260337268224 0.186628365500934 0.851952025025268 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2250A - 8.5 0 2.3 7.5 0 2.07807690745024 0.741810092201541 2.05243273549949 0.361429672880855 0.71777826930977 NA Possible flavoprotein ? Rv2251 - 10.6 9.1 4.7 8.1 4.3 21.0768307987714 0.455041208922776 0.670471306354088 0.678688565208279 0.4973352129442 0.684221070039329 Possible flavoprotein V - Conserved hypotheticals Rv2252 - 8.7 1.9 3.2 7.9 4 9.69278339791668 1.31714232707861 0.975195435834982 1.35064447461328 0.176809346827305 0.347342599258077 Diacylglycerol kinase V - Conserved hypotheticals Rv2253 - 2.2 3.4 2.6 4.4 0 1.94052305820681 0.566491868362227 1.98072349384996 0.286002498643123 0.774876207816768 NA Possible secreted unknown protein VI - Unknowns Rv2254c - 13.3 3.6 11.7 32.2 4.7 10.2918739652175 1.45752730379714 0.976387684579842 1.49277518225185 0.135496045741249 0.288950918523647 Probable integral membrane protein VI - Unknowns Rv2255c - 75.5 9.3 24.3 125.1 24.7 19.1742183289619 1.79673945431452 0.770997048562895 2.33041028842272 0.0197844765186374 0.0688045631915934 Hypothetical protein VI - Unknowns Rv2256c - 615.8 374.3 277.6 545.1 136 389.638137564804 0.399001980524057 0.268801590826179 1.48437358312389 0.137709838969349 0.292778061002062 hypothetical protein V - Conserved hypotheticals Rv2257c - 58 47.5 32 12.3 2.4 40.3653582475209 -1.95084715682823 0.578630355179756 -3.37149121086499 0.000747624242061577 0.00484110615243529 hypothetical protein VI - Unknowns Rv2258c - 92.3 96.2 60.6 30.1 7.7 105.374836748823 -1.48693247671561 0.417446944790049 -3.56196756323956 0.000368085869562557 0.00268816525771253 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2259 mscR 249.6 178.5 116.3 65.1 32 246.76359061877 -1.0750947590513 0.318457143719263 -3.37594800510757 0.000735618197337693 0.00480730563647621 S-nitrosomycothiol reductase MscR I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2260 - 170.2 91.7 99.1 37.8 19.2 93.7457811250089 -1.32814220888596 0.409735393004253 -3.24146322617576 0.00118917775659382 0.00720011557923982 hypothetical protein V - Conserved hypotheticals Rv2261c - 8.1 6.9 2.5 7.8 1.9 2.88696945526866 0.346428540673999 1.68205067175207 0.2059560668961 0.836825229074783 NA hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2262c - 15 12.1 7.9 5.7 0 13.8458929940994 -1.25429457057668 0.891018614914126 -1.40770860404254 0.159217373031242 0.324667780815578 hypothetical protein I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2263 - 26.5 7.7 10.6 16.8 8.2 25.6721705809118 0.541481964799991 0.627202475523982 0.863328806774275 0.387956710141526 0.5888863169926 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2264c - 8.8 2.4 5.7 9.7 8.4 30.6821494784206 1.59505738852962 0.636035940587098 2.50781015151013 0.0121481917155967 0.0468214309647916 Conserved hypothetical proline rich protein V - Conserved hypotheticals Rv2265 - 2.9 1.4 2.2 2.6 0.9 3.31536939304971 -0.0821739861953035 1.59605645340122 -0.051485638882127 0.958938545186121 NA Possible conserved integral membrane protein II.C.5 - Other membrane proteins Rv2266 cyp124 49.8 29.3 22.1 45.6 16.9 83.6658532136513 0.686531076987829 0.37992587267465 1.80701322643467 0.0707602169673279 0.179839194289762 Probable cytochrome P450 124 Cyp124 IV.F - Cytochrome P450 enzymes Rv2267c - 7 5.3 3.7 11.9 10.1 23.4307474940278 2.04819645754024 0.68656116004964 2.98326875553541 0.00285187450053286 0.0147035509183222 hypothetical protein VI - Unknowns Rv2268c cyp128 4.9 4 0.7 5.2 0 6.36144485339623 0.485248567548396 1.24745142358394 0.388991954615973 0.69728209791491 NA Probable cytochrome P450 128 Cyp128 IV.F - Cytochrome P450 enzymes Rv2269c - 1.6 0 3.2 0 0 0.38648471326448 -0.792698001188563 4.27508631399427 -0.185422689266813 0.852897513519571 NA Hypothetical protein VI - Unknowns Rv2270 lppN 13.1 6.3 5.1 14.1 0 6.31701861691885 0.44144825171408 1.18532658481322 0.372427529568689 0.709574560103329 NA Probable lipoprotein LppN II.C.1 - Lipoproteins(lppA-lpr0) Rv2271 - 47.1 44.6 28.6 63.6 69.1 39.8988198800092 1.78712508402705 0.592657875673177 3.01544138259721 0.00256605533362516 0.0136401851371457 hypothetical protein VI - Unknowns Rv2272 - 68.3 29.8 20.3 17.3 9.2 17.117949445688 -0.871292513419976 0.760551692610019 -1.14560590934973 0.251958251063866 0.444219076788558 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2273 - 21.7 16.1 9.4 2.7 3.4 6.10053944483859 -1.7872483442072 1.31248318105088 -1.36173047396781 0.173282960282451 NA Probable conserved transmembrane protein VI - Unknowns Rv2274c mazF8 17.8 16.2 0 13.2 0 4.53220080806462 -0.0497397440922595 1.52873313560007 -0.0325365774666325 0.974044146861381 NA Possible toxin MazF8 VI - Unknowns Rv2274A mazE8 18.3 13.2 4.3 7.7 0 2.97070420908231 -0.77649257893128 1.69420515113943 -0.458322640802416 0.646720660401458 NA Possible antitoxin MazE8 ? Rv2275 - 69 62.9 34.8 17.1 3.3 53.5969135232423 -1.7377738564106 0.516624393244725 -3.36370848750731 0.000769027260800861 0.00494354729175435 hypothetical protein VI - Unknowns Rv2276 cyp121 45.1 32.7 30.7 7.4 3.3 48.4598458846102 -2.08216150449972 0.530018204517625 -3.9284716765431 8.54874166847434e-05 0.00078648423349964 Cytochrome P450 121 Cyp121 IV.F - Cytochrome P450 enzymes Rv2277c - 1.7 1.9 0 0.9 0 0.951269386180995 0.0676769648473414 2.74768710615802 0.0246305209554851 0.980349674477979 NA Possible glycerolphosphodiesterase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2278 - 14.1 12.6 9.7 9 5 5.95213963882544 -0.103798500167135 1.17981605024725 -0.0879785455922405 0.929893728147127 NA Putative transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2279 - 4.9 9.8 2 5.5 2 8.43837997501756 0.0570363115282074 1.06407472169757 0.0536017916459989 0.957252429039089 0.981356904097382 Probable transposase IV.B.1.a - IS6110 Rv2280 - 177.7 81.4 98.1 433.1 132 560.018723173355 1.98590009819465 0.267976884899152 7.41071417014944 1.25621071734658e-13 8.08999701971197e-12 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2281 pitB 30.8 10.2 20.8 76.8 28.3 127.016849941611 2.11150296663155 0.38480081686114 5.48726217333762 4.08211056730805e-08 8.8704513063835e-07 Putative phosphate-transport permease PitB III.A.4 - Anions Rv2282c - 5.6 0 1.1 2.4 0 2.16742869892801 0.0282624905603301 2.04586768844482 0.0138144273551796 0.988978032267205 NA Probable transcription regulator (LysR family) I.J.1 - Repressors/activators Rv2283 - 1.6 0 0 0 0 0.0493734785565507 0.514412337427994 4.4620599203744 0.115285842549786 0.908218559547373 NA Hypothetical protein VI - Unknowns Rv2284 lipM 29.5 27.7 9.5 14.8 9.1 45.9927408567059 0.00774591347804046 0.539964353311796 0.0143452311815252 0.988554554071896 0.996155108273772 Probable esterase LipM II.B.5 - Esterases and lipases Rv2285 - 48.9 34.4 24.4 25.7 13 74.9696613151179 -0.0943114979505783 0.413280024690041 -0.228202410753609 0.819488887373522 0.904809737866899 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv2286c - 21.6 7.5 10.5 19.4 20.5 28.3657368511161 1.60818190895534 0.664032139463927 2.42184348223511 0.015441999937366 0.0565621135244576 hypothetical protein V - Conserved hypotheticals Rv2287 yjcE 7.8 3.2 3.3 2.8 2.4 12.3271573678405 -0.118034266565239 0.877847442705802 -0.134458746273065 0.893039830507513 0.945069339604903 Probable conserved integral membrane transport protein YjcE III.A.2 - Cations Rv2288 - 95.5 56.4 40.2 31.1 14.8 31.1207975657972 -0.743152682440113 0.574283266749977 -1.2940524745668 0.19564729593284 0.372583028402359 Hypothetical protein VI - Unknowns Rv2289 cdh 131.7 108.8 63 73.6 41.3 129.70334669656 0.0512296723727898 0.374967746963235 0.13662421044926 0.891327838776066 0.944103829229912 Probable CDP-diacylglycerol pyrophosphatase Cdh (CDP-diacylglycerol diphosphatase) (CDP-diacylglycerol phosphatidylhydrolase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2290 lppO 448.3 261 190.1 171.7 49.8 200.221329761506 -0.680696304577297 0.307765661407512 -2.21173571302351 0.026984931355829 0.0875280465772402 Probable conserved lipoprotein LppO II.C.1 - Lipoproteins(lppA-lpr0) Rv2291 sseB 301.3 166.4 125.3 134.9 33.2 225.709404940731 -0.486718028355292 0.303329153234679 -1.60458704072776 0.108584715263154 0.247176774718568 Probable thiosulfate sulfurtransferase SseB I.C.5 - Sulphur metabolism Rv2292c - 19.5 30.4 14.1 35.1 10.9 9.65169359151535 0.99951853390434 0.948723660579455 1.05354021980843 0.292093470987432 0.487786456500464 Hypothetical protein VI - Unknowns Rv2293c - 31.1 23.3 14.7 32 16.2 36.9627652015632 0.905020847532962 0.527274248542773 1.71641389662812 0.0860863148913436 0.209421516033749 hypothetical protein VI - Unknowns Rv2294 - 6 3.8 0.9 5.8 0 5.84121066991712 0.506807873453432 1.28430600638728 0.394616135821921 0.693126203361062 NA Probable aminotransferase IV.H - Miscellaneous transferases Rv2295 - 249.9 187.1 127.6 156.8 40.1 175.714527877352 -0.230125748897312 0.322015439749329 -0.714641972063365 0.474830302541075 0.663975101302996 hypothetical protein V - Conserved hypotheticals Rv2296 - 96.8 75.6 58.4 49 16.6 97.9789964611588 -0.520161719857966 0.378764283998857 -1.37331248439342 0.169655223123993 0.337855433184778 Probable haloalkane dehalogenase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2297 - 64.2 65.6 64.5 32.9 17.3 42.5475249576582 -0.711661660017325 0.554177549677382 -1.28417627244486 0.19908028537921 0.376411819168786 hypothetical protein VI - Unknowns Rv2298 - 54 48.1 46.3 20.7 15.9 71.7990816963878 -0.625021833883503 0.48811057156046 -1.28049231116906 0.200372047150293 0.37831438753003 hypothetical protein V - Conserved hypotheticals Rv2299c htpG 59.8 35.2 35 72.1 21.3 172.795474262632 0.822575714442941 0.312311435620963 2.63383155601532 0.00844273609205061 0.0350987925329146 Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) III.B - Chaperones/Heat shock Rv2300c - 10.9 3.7 6.9 21.7 4.2 17.053614022038 1.4895687957841 0.741516110928905 2.00881514754697 0.0445567412285514 0.128727550922944 hypothetical protein V - Conserved hypotheticals Rv2301 cut2 27 16.2 18.1 36.8 25.6 41.4761091057657 1.54505103659965 0.538240933672579 2.87055654808212 0.00409749901020593 0.0195071794276201 Probable cutinase Cut2 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2302 - 188 91.3 84 254.5 106 75.2663018981574 1.39000982401201 0.400823595386322 3.46788422640712 0.000524573233046992 0.00361376285006291 hypothetical protein V - Conserved hypotheticals Rv2303c - 11.6 8.9 7.4 18.4 6.4 20.1475973822028 1.25477310793719 0.66377149544262 1.8903690751295 0.0587086163809629 0.157893636462696 Probable antibiotic-resistance protein IV.D - Antibiotic production and resistance Rv2304c - 29.3 26.4 10.7 37.3 11.3 9.36017770739277 1.01902958216553 0.945436482178716 1.07784034292523 0.281105012269669 0.477999977656826 Hypothetical protein VI - Unknowns Rv2305 - 19.3 6.6 11.1 9.2 6.9 27.8265513164148 0.184806051052989 0.635611098463769 0.290753341940777 0.771239972069095 0.880635712788115 hypothetical protein VI - Unknowns Rv2306A - 11.8 4 3.1 9.2 9.9 11.1458567691988 1.74558886235829 0.966954751333686 1.80524358554592 0.0710365732604573 0.18029385846758 Possible conserved membrane protein ? Rv2306B - 12.4 4 7.4 6.6 9.1 7.78972994735322 0.847645329960552 1.11942151423186 0.757217294096944 0.44891969085249 0.642973532146995 Possible conserved membrane protein ? Rv2307c - 32.3 21.2 13.4 19.1 13.1 34.3952762469887 0.404523704377588 0.563580115326537 0.717774977108992 0.472896044559136 0.663102846329557 hypothetical protein V - Conserved hypotheticals Rv2307A - 16.4 9.3 4.6 52.9 6.5 6.1229658396925 2.44115373585301 1.20277249327314 2.02960555674983 0.0423966496305182 NA Hypothetical glycine rich protein ? Rv2307B - 30.9 12.2 18.7 57.4 9.1 20.6914728717376 1.3265327731279 0.682571826302487 1.94343323590393 0.0519638348137283 0.143622338023031 Hypothetical glycine rich protein ? Rv2307D - 72.2 46.6 22.9 111 25.5 18.5250218964786 1.23068356993588 0.706302039825562 1.74243241636373 0.0814328077638982 0.201280533914674 Hypothetical protein ? Rv2308 - 21 9.6 4.3 11.5 8.3 15.9100370197067 0.782639565164597 0.80423076134685 0.973152983919573 0.330477274034966 0.530418644288575 hypothetical protein I.J.1 - Repressors/activators Rv2309c - 114.2 35.5 23.7 110.9 12.1 44.1888754293216 0.776554610029235 0.586091771670471 1.32497101574368 0.185180764811531 0.358616877508171 Possible integrase (fragment) IV.B.3 - Phage-related functions Rv2309A - 1.3 3.4 0 1.3 0.2 0.159481070640853 1.1765567663428 4.42884339089194 0.265657794258978 0.79050277092913 NA Hypothetical protein ? Rv2310 - 0.3 0.1 0 3.1 3.2 0.366370150502383 2.65528791214303 4.34255985950405 0.611456836071405 0.540897185599125 NA Possible excisionase IV.B.3 - Phage-related functions Rv2311 - 8.3 16.1 1.1 1.1 6.9 7.97862735785495 0.190528185306681 1.38283863825892 0.137780490098662 0.890413903932798 0.943700193815072 hypothetical protein VI - Unknowns Rv2312 - 24.1 18.8 6.7 33.1 0.5 6.52940048148449 0.792977095378647 1.19113059908789 0.665734803543684 0.505580623610526 NA Hypothetical protein VI - Unknowns Rv2313c - 110.8 69.9 65.6 103.9 22.4 118.432347428261 0.29703261746969 0.358286551823388 0.829036468039437 0.40708377180195 0.604819932769508 Hypothetical protein VI - Unknowns Rv2314c - 105.1 54.8 66.5 38.2 4.2 122.322540023139 -1.25022647189732 0.433741119919693 -2.88242551715825 0.00394626420261569 0.0189143001429835 hypothetical protein V - Conserved hypotheticals Rv2315c - 71.8 39.2 52.5 32.2 13 118.216201068986 -0.546302869726791 0.382476686109179 -1.42832985530221 0.153196938448145 0.315478811618214 hypothetical protein V - Conserved hypotheticals Rv2316 uspA 1.8 1.8 1.2 0 0 0.982744583914293 -2.16975587027337 2.75979300239602 -0.78620239575563 0.431748922762354 NA Probable sugar-transport integral membrane protein ABC transporter UspA III.A.3 - Carbohydrates, organic acids and alcohols Rv2317 uspB 1.8 2.4 1.4 0.1 0 0.958057844636018 -2.12283278849661 2.7855784098523 -0.762079710622531 0.446012431456901 NA Probable sugar-transport integral membrane protein ABC transporter UspB III.A.3 - Carbohydrates, organic acids and alcohols Rv2318 uspC 11.6 5.2 5.3 13.8 11.9 31.5269075269007 1.81710474993399 0.614663045689784 2.95626158539401 0.00311392870172647 0.0156447311510853 Probable periplasmic sugar-binding lipoprotein UspC III.A.3 - Carbohydrates, organic acids and alcohols Rv2319c - 9.6 1.4 7.4 5.2 0 6.59116409648171 -0.638933801952903 1.25954876970983 -0.507271982886455 0.611963994036488 NA Universal stress protein family protein VI - Unknowns Rv2320c rocE 16.3 13.2 6 14.9 1.3 24.2093909470334 0.0771141980962739 0.687795085173747 0.11211798362414 0.910729858459139 0.956928258280116 Probable cationic amino acid transport integral membrane protein RocE III.A.1 - Amino acids Rv2321c rocD2 14.5 16.1 3 12.9 0.2 7.66327813823519 -0.0700562253504074 1.15779344505207 -0.0605083969423033 0.951750728312814 0.978748655233813 Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase) I.A.2 - Amino acids and amines Rv2322c rocD1 18.1 10.3 7.5 15.6 3 11.730774978839 0.31461841221757 0.865963094008806 0.363316190255991 0.7163687004021 0.847091552695191 Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) I.A.2 - Amino acids and amines Rv2323c - 21.6 9.5 9.8 21.1 10.1 26.6639470884325 0.990865298648188 0.596824543731818 1.66022880435264 0.0968684320762099 0.228264495749882 hypothetical protein V - Conserved hypotheticals Rv2324 - 18.1 11.1 8.5 16.8 0 7.22570298299831 0.166807229212577 1.12049078320139 0.148869791446197 0.881656378486598 0.939761327896338 Probable transcriptional regulatory protein (probably AsnC-family) I.J.1 - Repressors/activators Rv2325c - 180.5 89.7 74.5 80.1 32.7 141.958658349507 -0.202041483059247 0.337172347553764 -0.599223170361058 0.549024073616197 0.726392246777547 hypothetical protein V - Conserved hypotheticals Rv2326c - 282.7 169.4 160.2 109.1 35 565.163621486366 -0.756039910632546 0.256301039946537 -2.94981210685002 0.00317967236440895 0.0159298437266429 Possible transmembrane ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2327 - 806.9 419 398.4 62.3 30.3 273.565363354106 -2.79778640657962 0.331796100698114 -8.43224619184178 3.39092662813166e-17 3.87440713446527e-15 hypothetical protein V - Conserved hypotheticals Rv2328 PE23 91.5 55.2 48.9 18.3 3.2 81.6028985209536 -1.86103787982029 0.436372844792445 -4.26478847625238 2.00091670704758e-05 0.000233902540474011 PE family protein PE23 IV.C.1.a - PE subfamily Rv2329c narK1 34.9 21.8 17.5 106 29.4 142.10974089166 2.18599075020094 0.328242853812374 6.65967506927194 2.74433629731425e-11 1.12652296169966e-09 Probable nitrite extrusion protein 1 NarK1 (nitrite facilitator 1) III.A.4 - Anions Rv2330c lppP 6.7 2.4 5.1 2.8 3.7 4.07050947777052 -0.0983878539320513 1.45142991125691 -0.0677868446619301 0.945955316112305 NA Probable lipoprotein LppP II.C.1 - Lipoproteins(lppA-lpr0) Rv2331 - 271.3 168.3 112.4 112.2 38.1 96.0615010186102 -0.518549391025331 0.375264779589638 -1.38182270020751 0.167026147204839 0.334429968004262 Hypothetical protein VI - Unknowns Rv2331A - 49.3 22.5 17.1 22.6 0.4 11.4358179577165 -0.64584351391514 0.94801732889034 -0.681257076461992 0.495708838234446 0.683456496189807 Hypothetical protein ? Rv2332 mez 27 29.3 16.3 5.3 3.7 48.0348363832499 -1.72897649021965 0.563501944991973 -3.06827066984531 0.00215301510377641 0.0116962875729694 Probable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2333c stp 12.5 1.1 5.6 7.3 3.7 19.1991269630223 0.656767808083844 0.797499866954929 0.823533439060702 0.410204709493602 0.60665765387321 Integral membrane drug efflux protein Stp III.A.6 - Efflux proteins Rv2334 cysK1 358 216.4 184.6 89.8 32.3 283.181943194639 -1.28744899084792 0.289158114997979 -4.45240484036535 8.4913875408538e-06 0.000112225726379493 Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) I.D.3 - Serine family Rv2335 cysE 261.5 182.8 129.7 52.7 21.6 152.241883769669 -1.6175069006813 0.346945489883345 -4.6621355453422 3.12944958576544e-06 4.63787047396702e-05 Probable serine acetyltransferase CysE (sat) I.D.3 - Serine family Rv2336 - 130.8 108.1 54.4 105.8 45.8 171.975965219064 0.473015240133831 0.340327036401257 1.38988440394177 0.164563982259582 0.331561789057701 Hypothetical protein VI - Unknowns Rv2337c - 38 20.8 15.8 78.9 16.9 76.5618937897802 1.66451151954591 0.404481004073923 4.11517847014072 3.86879951799404e-05 0.000407835949188539 Hypothetical protein VI - Unknowns Rv2338c moeW 44.8 28.7 16 127 30.5 98.9620580991707 2.13729868864783 0.380659943941225 5.61471918090188 1.96881723991969e-08 4.61824547271228e-07 Possible molybdopterin biosynthesis protein MoeW I.G.4 - Molybdopterin Rv2339 mmpL9 61.5 53.9 24.4 33.8 14 203.713256653074 -0.13251981257343 0.3430401638533 -0.386309903437726 0.699267166843132 0.833940843420327 Probable conserved transmembrane transport protein MmpL9 II.C.4 - Conserved membrane proteins Rv2340c PE_PGRS39 50 29 16.8 67 33.2 108.26488347178 1.55602831187946 0.377858587879291 4.11801759121732 3.82145531803643e-05 0.00040404760407418 PE-PGRS family protein PE_PGRS39 IV.C.1.a - PE subfamily Rv2341 lppQ 7.5 6.8 1.6 9.4 0 3.06917179585191 0.689021978041804 1.62937682870896 0.422874540684216 0.672386798877141 NA Probable conserved lipoprotein LppQ II.C.1 - Lipoproteins(lppA-lpr0) Rv2342 - 76.6 34.5 24.3 27.2 0 12.2201765769572 -0.931817073800056 0.936220178721374 -0.995296934394929 0.319591868335379 0.518787533292352 hypothetical protein VI - Unknowns Rv2343c dnaG 111.2 85.5 62.1 47.1 9.2 209.183596791791 -0.946310199276023 0.330817881716817 -2.86051707472715 0.00422950776706199 0.0200547744456942 Probable DNA primase DnaG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2344c dgt 78.4 34.5 38.1 48.2 20.5 110.01530022994 0.263827101910947 0.365630346482763 0.721567847004145 0.470560213250607 0.661541313593856 Probable deoxyguanosine triphosphate triphosphohydrolase Dgt (dGTPase) (dGTP triphosphohydrolase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2345 - 57.2 31 34.5 40.1 12.5 130.570190349221 0.0788706087661298 0.344160141002171 0.22916834162278 0.818738077558395 0.904262635083204 Possible conserved transmembrane protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2346c esxO 1018.2 674.7 630.6 1241.8 719.3 559.036378434171 1.27240355733746 0.30133943586172 4.22249266412427 2.41615265264539e-05 0.000275177257095497 Putative ESAT-6 like protein EsxO (ESAT-6 like protein 6) V - Conserved hypotheticals Rv2347c esxP 514.8 481.9 524.5 861 524.7 412.725787844347 1.31513938622756 0.360516886507508 3.64792728287409 0.000264364431116588 0.00207622797120833 Putative ESAT-6 like protein EsxP (ESAT-6 like protein 7) V - Conserved hypotheticals Rv2348c - 400.7 362.7 372.3 656.9 476.8 369.517335936079 1.52689806748813 0.372653412416788 4.09736773262229 4.1787479285298e-05 0.000436372797143511 Hypothetical protein VI - Unknowns Rv2349c plcC 41.7 23 16.2 15.5 2.6 49.0572468908756 -0.832127253576913 0.501288845684454 -1.659975602371 0.0969193607706356 0.228264495749882 Probable phospholipase C 3 PlcC II.B.5 - Esterases and lipases Rv2350c plcB 57.9 47.7 28.9 20.3 4.2 82.5065680651019 -1.16524488572123 0.4259221709746 -2.73581645927213 0.00622257223219597 0.0276541415890065 Membrane-associated phospholipase C 2 PlcB II.B.5 - Esterases and lipases Rv2351c plcA 9.4 6.8 7.4 9.4 1.2 18.0750454314803 0.0139698895219372 0.746343633523802 0.0187177714050826 0.985066251207181 0.995391798001726 Membrane-associated phospholipase C 1 PlcA (MTP40 antigen) II.B.5 - Esterases and lipases Rv2352c PPE38 6.8 13 9.6 5.7 3.4 18.0154547530776 -0.439048976213629 0.800717617094486 -0.548319366079116 0.583472632109699 0.752675155251687 PPE family protein PPE38 IV.C.2 - PPE family Rv2353c PPE39 0.9 1.6 0.8 0.8 0 1.115573445941 -0.140177217703423 2.43393392276099 -0.0575928608383953 0.954072936461083 NA PPE family protein PPE39 IV.C.2 - PPE family Rv2354 - 6.7 0 1.7 10.1 3 1.57951913276558 1.75468849592842 2.44883610447464 0.716539785052241 0.473658110440454 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2355 - 5.8 3.5 6.4 4.8 1.1 6.54452388474842 -0.461757675998202 1.20588924206292 -0.382918812019809 0.701779962545056 NA Probable transposase IV.B.1.a - IS6110 Rv2356c PPE40 72.9 53.9 56.2 64.7 29.9 212.37786768606 0.413882491266237 0.332979153049978 1.24296817826345 0.21387955999315 0.395386952763955 PPE family protein PPE40 IV.C.2 - PPE family Rv2357c glyS 32.6 23.3 17.8 32.6 17.1 73.9563358052748 0.866700591019492 0.416359372789102 2.0816166217507 0.0373775019295083 0.112673286667505 Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2358 smtB 111.8 50.7 57.5 92.3 29.7 53.7191097983123 0.490118036569731 0.449747686677693 1.08976221798995 0.275817900978106 0.471727187476799 Probable transcriptional regulatory protein SmtB (probably ArsR-family) I.J.1 - Repressors/activators Rv2359 zur 184.4 131.5 94.6 133.5 53.5 90.9323909371761 0.221406232323095 0.376285434997841 0.58839968739254 0.55626404753064 0.731081891431363 Probable zinc uptake regulation protein Zur I.J.1 - Repressors/activators Rv2360c - 102.4 56.5 33.6 42.8 10.7 34.648006816932 -0.530675506408361 0.560001222539158 -0.947632764089642 0.343316440462504 0.54487031010848 hypothetical protein VI - Unknowns Rv2361c - 126.7 85.1 60.2 67.7 39.1 133.973504136502 0.112655130086379 0.362966909181716 0.310373004361065 0.756277320584421 0.873340521495482 Long (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase) V - Conserved hypotheticals Rv2362c recO 89.8 55.9 36.6 46.1 6 62.4206663579503 -0.51384176870585 0.467288043306012 -1.0996253297441 0.271495400995169 0.467267594910053 Possible DNA repair protein RecO V - Conserved hypotheticals Rv2363 amiA2 16.5 9.2 8.8 9.5 1.5 21.8532331530492 -0.474074516286356 0.689475186171615 -0.687587495234899 0.491712585051358 0.680064809157326 Probable amidase AmiA2 (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2364c era 255.2 186.3 93.5 108.7 17.6 198.944475649505 -0.829818226534914 0.364638303547757 -2.27572972576161 0.0228621910617575 0.0771664330308866 Probable GTP-binding protein Era I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2365c - 240 90.8 90.2 58.2 6.5 50.8962484117165 -1.42975890081783 0.556387908004694 -2.56971598456407 0.010178192240176 0.0401908103842847 hypothetical protein V - Conserved hypotheticals Rv2366c - 337 189 174.6 159.3 41.4 416.897879236256 -0.512908127668867 0.2695782693223 -1.90263157693786 0.0570886358267917 0.15506744486081 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2367c - 583.9 388.6 286.7 346.8 92.3 337.003972513824 -0.223797700562049 0.27536476317738 -0.812731803371249 0.416371842864385 0.612100983924352 hypothetical protein V - Conserved hypotheticals Rv2368c phoH1 640.6 400.3 336.7 466.4 141.7 793.728225911914 0.139316516260808 0.238117706325751 0.585074156855097 0.55849785487469 0.732666445172649 Probable PHOH-like protein PhoH1 (phosphate starvation-inducible protein PSIH) I.A.4 - Phosphorous compounds Rv2369c - 76.9 30 26.3 68.7 26.1 26.4717790179929 0.895759684665086 0.604433909632736 1.48198118998546 0.138345300027077 0.293952641089327 Hypothetical protein VI - Unknowns Rv2370c - 3.8 1.6 1.8 3.9 1.5 5.75909134147246 0.832714506164325 1.17191362483007 0.710559625318011 0.477357169962379 NA hypothetical protein V - Conserved hypotheticals Rv2371 PE_PGRS40 24.1 12.9 2.7 16 0 2.73599149981573 0.208923180789086 1.8472521624902 0.113099437657415 0.909951720817071 NA PE-PGRS family protein PE_PGRS40 IV.C.1.a - PE subfamily Rv2372c - 84 43.3 36.6 69.2 14 69.9540283825611 0.320453689242283 0.420200667944406 0.762620608886516 0.445689690190765 0.640538218153687 hypothetical protein V - Conserved hypotheticals Rv2373c dnaJ2 162.6 76.6 85.1 175.9 53.9 253.507496017885 0.83540962026448 0.292358459718081 2.85748399779523 0.00427014164848353 0.0201664556252382 Probable chaperone protein DnaJ2 III.B - Chaperones/Heat shock Rv2374c hrcA 239.9 175.1 145.6 206.8 77.4 346.481228011895 0.372360941520722 0.277128244198587 1.34364125388061 0.179064422459069 0.350936531098739 Probable heat shock protein transcriptional repressor HrcA III.B - Chaperones/Heat shock Rv2375 - 138.5 60.8 61.7 103.7 19.4 42.753420456199 0.220593371858912 0.507633542599559 0.434552395275669 0.663887355561976 0.811697968036078 hypothetical protein VI - Unknowns Rv2376c cfp2 518.1 272.7 138.8 155.6 25.3 178.077618259973 -1.0582611353671 0.389950299255498 -2.71383593598352 0.00665090959125386 0.029264002201517 Low molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2) V - Conserved hypotheticals Rv2377c mbtH 92 44.3 44.3 14 4.5 12.6908976692413 -2.22213347303024 0.965407504880905 -2.30175699048908 0.0213488802777864 0.0732020657733974 Putative conserved protein MbtH I.I - Polyketide and non-ribosomal peptide synthesis Rv2378c mbtG 29.8 18.4 13.3 2.9 0 25.6610608438695 -2.90902004253596 0.761436920522964 -3.82043471248808 0.00013321666629005 0.00115086202926672 Lysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2379c mbtF 30.1 13.9 10.6 5.3 0.4 80.4994545290924 -1.94547532746838 0.500469419479101 -3.88730110521693 0.000101364984205992 0.000915905035861288 Peptide synthetase MbtF (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2380c mbtE 22.6 11.9 15 6.3 1.6 98.3852741993961 -1.38284324147556 0.411768872369658 -3.35829960510988 0.000784235614593814 0.00500497756196629 Peptide synthetase MbtE (peptide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2381c mbtD 9.4 4.4 5.3 2.8 0.7 21.749676404879 -1.18354422844902 0.701164143698103 -1.68797026928207 0.0914169362209681 0.218821599985213 Polyketide synthetase MbtD (polyketide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2382c mbtC 41.6 24.5 27 9.6 5.9 51.8294611383145 -1.32052207704801 0.506878006835335 -2.6052068924683 0.00918187972384162 0.0370834868664162 Polyketide synthetase MbtC (polyketide synthase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2383c mbtB 3.7 3 3.1 2.9 1.4 24.3585913543729 0.156364402394925 0.640590093736563 0.244094318541286 0.807157772636245 0.898759141992323 Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) I.I - Polyketide and non-ribosomal peptide synthesis Rv2384 mbtA 2 5.5 0 1.2 1.2 6.08303389593974 -0.585636534538297 1.41328679509677 -0.414379117225245 0.678596480077494 NA Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase I.I - Polyketide and non-ribosomal peptide synthesis Rv2385 mbtJ 7.9 1.6 0 2.9 0 2.86897317254298 -0.158607633594767 1.88290000959254 -0.0842358238816356 0.932868936054103 NA Putative acetyl hydrolase MbtJ II.B.5 - Esterases and lipases Rv2386c mbtI 3.9 0.2 1.7 15.9 2.9 13.3074732918849 2.91483987141901 0.907934597468609 3.21040731297806 0.00132547007054522 0.00787720635884423 Isochorismate synthase MbtI I.D.4 - Aromatic amino acid family Rv2387 - 31.7 26.1 27.4 29.5 7.5 58.6255328982038 0.0600297069715288 0.464771503962613 0.129159611679544 0.897231353668576 0.948654762595253 hypothetical protein V - Conserved hypotheticals Rv2388c hemN 107.2 79.2 51.5 25.2 5.7 100.4576125571 -1.62947194504427 0.401764030609483 -4.05579350289853 4.99643874804411e-05 0.000501342380894398 Probable oxygen-independent coproporphyrinogen III oxidase HemN (coproporphyrinogenase) (coprogen oxidase) I.G.12 - Heme and porphyrin Rv2389c rpfD 105.3 66.9 63.7 120.4 38.3 73.8607845214499 0.749495863084595 0.398762287216995 1.87955553248379 0.0601686784388828 0.160600948779595 Probable resuscitation-promoting factor RpfD V - Conserved hypotheticals Rv2390c - 62.1 28.7 34.2 53.6 17.7 42.1711380166264 0.528274061331347 0.493818132977806 1.06977453044457 0.284720809281263 0.480916121351566 hypothetical protein V - Conserved hypotheticals Rv2391 sirA 1051.3 808.9 585.5 443.4 211.2 1972.44307882468 -0.444567403626878 0.260635095194217 -1.7057081407076 0.0880624332225943 0.212332973774288 Ferredoxin-dependent sulfite reductase SirA I.B.6.b - anaerobic Rv2392 cysH 725.4 622.5 370 223.5 86.6 549.823223410986 -1.09831317433959 0.283680356496313 -3.87165748064007 0.000108097782528817 0.000970443516359783 Probable 3'-phosphoadenosine 5'-phosphosulfate reductase CysH (PAPS reductase, thioredoxin DEP.) (padops reductase) (3'-phosphoadenylylsulfate reductase) (PAPS sulfotransferase) I.B.6.b - anaerobic Rv2393 che1 352.7 243.9 158.7 38.3 9 217.53109056961 -2.6636675537178 0.346557929975243 -7.68606724396143 1.51726781829063e-14 1.22140059372395e-12 Ferrochelatase Che1 V - Conserved hypotheticals Rv2394 ggtB 159.1 151.3 84 24.5 6.1 273.595145790104 -2.39050725625042 0.346455650731939 -6.89989397257663 5.20413665955442e-12 2.42540158528181e-10 Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv2395 - 57.4 38.8 19 27.8 6.6 103.374986591819 -0.400027550591725 0.391478502998411 -1.02183784684941 0.306857653278591 0.503043582343252 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2395A aprA 4475.9 1970.2 1523 5110.4 1697.9 1294.93775327567 1.20579821719659 0.253401360326444 4.75845202899948 1.95083240942872e-06 3.00428191052022e-05 Acid and phagosome regulated protein A AprA ? Rv2395B aprB 959.8 574.5 540.4 1238.8 307.2 233.446599660527 0.841670548043577 0.296956005518708 2.83432741686227 0.00459222549305013 0.0213460140372488 Acid and phagosome regulated protein B AprB ? Rv2396 PE_PGRS41 187.8 105.8 83.9 155.7 37.9 228.952614434613 0.333273420119182 0.297486837600252 1.12029635599212 0.262587494407006 0.455923973132164 PE-PGRS family protein PE_PGRS41 IV.C.1.b - PE_PGRS subfamily Rv2397c cysA1 30.1 17.2 12.8 13.2 1.9 25.4014069015107 -0.732244719402462 0.656210738423437 -1.11586823641701 0.264478539924443 0.458308702745781 Sulfate-transport ATP-binding protein ABC transporter CysA1 III.A.4 - Anions Rv2398c cysW 44.3 31.1 19.6 34.9 9.6 41.6352852977181 0.21569418518776 0.495857014695342 0.434992707162335 0.663567720995238 0.811587316217242 Probable sulfate-transport integral membrane protein ABC transporter CysW III.A.4 - Anions Rv2399c cysT 25.8 22.2 12.1 20.6 4.6 25.9943335809223 0.0409838218705899 0.613557412753349 0.0667970446101766 0.946743276215897 0.976271183980787 Probable sulfate-transport integral membrane protein ABC transporter CysT III.A.4 - Anions Rv2400c subI 48.6 17.7 36.7 47 23.8 80.1191875096846 0.840404552769493 0.451908843066982 1.85967715760085 0.062931215674056 0.165112863642597 Probable sulfate-binding lipoprotein SubI III.A.4 - Anions Rv2401 - 5.8 3.2 0 1.9 6 2.23226069204504 0.78188428836563 1.99781737001462 0.391369251314452 0.695524317302876 NA Hypothetical protein VI - Unknowns Rv2401A - 14.9 8.2 5.2 19.7 18.1 6.54746166193405 2.19172359018757 1.19411745152249 1.83543384898458 0.066441432204291 NA Possible conserved membrane protein ? Rv2402 - 47.2 32.4 25.3 22.2 12.1 103.129691843949 -0.213822013062162 0.382139347987659 -0.559539377947196 0.575793664634879 0.745417090693254 hypothetical protein V - Conserved hypotheticals Rv2403c lppR 46.7 30.8 21.8 25.1 24.1 48.9647004180052 0.540692388143471 0.53326226208606 1.01393334309528 0.310614559824308 0.50736458873468 Probable conserved lipoprotein LppR II.C.1 - Lipoproteins(lppA-lpr0) Rv2404c lepA 27.4 13.6 15.6 32.4 15.2 88.8618483476233 1.17147070131792 0.391704822790389 2.99069767120228 0.00278340915634202 0.0144769974034706 Probable GTP-binding protein LepA (GTP-binding elongation factor) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2405 - 168.7 91.9 66.9 122.7 15.7 89.8448034737633 -0.0076317977020114 0.427058064561288 -0.0178706324392948 0.985742057190533 0.995579802272275 hypothetical protein VI - Unknowns Rv2406c - 471.7 329.8 156.3 275 54.2 190.074446186761 -0.257613008659066 0.355297042140403 -0.725063758220833 0.468412916788945 0.660421053780088 hypothetical protein V - Conserved hypotheticals Rv2407 - 10.3 7 2.3 5.7 2.4 7.45108946564467 -0.00485538574215081 1.06832411989417 -0.00454486204302098 0.996373737228774 0.999433305040629 hypothetical protein V - Conserved hypotheticals Rv2408 PE24 1.6 0 0 0.5 0 0.307601506310505 0.424338093240158 4.42394701211946 0.0959184393659506 0.923585349607653 NA Possible PE family-related protein PE24 IV.C.1.a - PE subfamily Rv2409c - 50.3 30.6 41.2 34.9 14.7 56.4013232341861 0.0100025577804356 0.471623098231111 0.021208795366367 0.983079098173729 0.994591878243744 hypothetical protein V - Conserved hypotheticals Rv2410c - 46.6 27.6 27.8 48.4 14 62.3137768383629 0.583675012834317 0.424548294771743 1.37481417313931 0.169189062948419 0.337615583641296 hypothetical protein V - Conserved hypotheticals Rv2411c - 45.1 23.3 27.7 49.1 23.5 120.056364229611 0.993967889303365 0.363463652927249 2.73471055853367 0.00624351495395455 0.0276777596582065 hypothetical protein V - Conserved hypotheticals Rv2412 rpsT 144.9 97.6 54.7 252.3 91.9 72.2553172908972 1.62111962809655 0.406568786673945 3.98731944318353 6.68240244746929e-05 0.00063970458024152 30S ribosomal protein S20 RpsT II.A.1 - Ribosomal protein synthesis and modification Rv2413c - 48.6 19.7 9.9 32.3 8.3 39.1422286696451 0.431958102477187 0.55558402638667 0.777484740312813 0.436872834018028 0.631851195627543 hypothetical protein V - Conserved hypotheticals Rv2414c - 20.8 12.3 7.1 11.1 8.2 37.4402338658809 0.404878645585012 0.554890546560029 0.729654970867686 0.465601111879944 0.657923657604383 hypothetical protein V - Conserved hypotheticals Rv2415c - 6.6 6 4.6 4.3 0.9 6.13715911791739 -0.727965774092186 1.2263510589741 -0.593603086787535 0.552777615978293 NA hypothetical protein V - Conserved hypotheticals Rv2416c eis 11.4 5.6 2.8 9.9 8.2 21.0845892583932 1.43626781414757 0.715588460460399 2.00711427518479 0.0447374965722131 0.129144427757766 Enhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv2417c - 76.8 36.1 29.9 20.6 8.6 49.8123829343052 -0.90049538182934 0.485968727160915 -1.85299039115158 0.0638837359165053 0.166993500085802 hypothetical protein V - Conserved hypotheticals Rv2418c - 43 17.3 34 46 15.9 47.3706545633986 0.701626223091152 0.507182351704522 1.38338059424416 0.166548197601886 0.333850433449847 hypothetical protein VI - Unknowns Rv2419c gpgP 35.4 24.3 13.6 36.4 1 23.291757154505 0.170899470264225 0.740484985763786 0.230793970910765 0.817474865320515 0.903581426877352 Glucosyl-3-phosphoglycerate phosphatase GpgP I.B.1 - Glycolysis Rv2420c - 47.6 47.3 33.5 66.9 29.2 36.2418050236584 0.960035746773521 0.537102264032853 1.78743567298535 0.0738671002883823 0.18519285423085 hypothetical protein V - Conserved hypotheticals Rv2421c nadD 23.6 9.5 18.2 29.1 14.7 25.7366660882043 1.08544974315998 0.633371184516812 1.71376559226964 0.0865717849663827 0.20988176752288 Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nicotinate mononucleotide adenylyltransferase) (NAMN adenylyltransferase) V - Conserved hypotheticals Rv2422 - 1 0 4 0 0 0.337111234707929 -0.540146991889947 4.45488346974389 -0.121248287538484 0.903494378288365 NA Hypothetical protein VI - Unknowns Rv2423 - 3.3 8.2 2 5.8 3.3 9.31667438578625 0.712289836043515 1.01956009971093 0.698624667879278 0.484786623484872 0.67258684699703 Hypothetical protein VI - Unknowns Rv2424c - 19.9 10.6 7.2 5.6 2 14.433744939634 -1.06052515004981 0.815359022642606 -1.30068487696697 0.193366340851449 0.369419406308433 Probable transposase IV.B.1.c - Others Rv2425c - 90.5 65 34.9 30 7.2 109.687177034192 -1.03652023848825 0.388481908934652 -2.6681300072138 0.00762747372023032 0.0326680917981328 hypothetical protein V - Conserved hypotheticals Rv2426c - 91.6 79.8 68 21.9 0.3 75.4540383890488 -2.21949091681423 0.55615775744698 -3.99075781483784 6.58625096700923e-05 0.000632208697158447 hypothetical protein V - Conserved hypotheticals Rv2427c proA 177.3 96.4 86.9 54.1 25.3 196.531158126264 -0.783909025028307 0.320117473154629 -2.44881673375464 0.0143326353169765 0.0532698785862861 Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase) I.D.1 - Glutamate family Rv2428 ahpC 25.2 6.5 19.4 18.9 15.7 22.0887708350249 0.851014722703167 0.724848544659944 1.17405867608165 0.240371524028875 0.427502862927441 Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C) III.F - Detoxification Rv2429 ahpD 37.4 1.1 32.1 19.6 11 21.8261098163851 0.318213595238726 1.70501660894573 0.186633721671186 0.851947825202659 0.919904717299549 Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D) III.F - Detoxification Rv2430c PPE41 450.9 286.6 182.3 398.7 112.2 317.342492752637 0.488134621543315 0.279103417705294 1.74893817337177 0.0803017071400102 0.199248328929529 PPE family protein PPE41 IV.C.2 - PPE family Rv2431c PE25 446.4 326.6 264.7 648.8 295.7 264.200588699464 1.29101940328968 0.300601002466373 4.29479407153375 1.74855565389058e-05 0.00020853145205658 PE family protein PE25 IV.C.1.a - PE subfamily Rv2432c - 29.6 23 23.2 65 19.3 27.0768205047929 1.44385746296299 0.594234446561219 2.42977745790144 0.0151080961885121 0.0557425798955311 Hypothetical protein VI - Unknowns Rv2433c - 21.7 16.4 11.7 8 5.6 6.35391592573287 -0.675337214187344 1.17112328631032 -0.576657660283597 0.564170739537972 NA Hypothetical protein VI - Unknowns Rv2434c - 11.6 9.9 6.1 3.1 0 13.745459937994 -1.72850740634838 0.912281812359076 -1.89470773496911 0.0581311324298893 0.157056042003561 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv2435c - 14.9 21.3 7 10 4.9 49.7208772245839 -0.136566027212934 0.546676658335272 -0.249811337525919 0.80273325160119 0.896651270000447 Probable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-) VI - Unknowns Rv2436 rbsK 44.3 36.1 9.5 14.1 0 28.4933498726179 -1.33690486553154 0.746856757932239 -1.79004186724228 0.073447181062651 0.18463443245132 Ribokinase RbsK I.B.5 - Pentose phosphate pathway Rv2437 - 14 13.2 5 2.8 0 4.33431646859696 -2.08089810502518 1.47913531571837 -1.40683417055359 0.159476567476862 NA Conserved transmembrane protein V - Conserved hypotheticals Rv2438c nadE 162 124.9 93.8 115.2 56.4 455.990940549506 0.292608379763773 0.287789104754082 1.01674585635828 0.309274345037996 0.50574779784145 Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) V - Conserved hypotheticals Rv2438A - 0 0 0 0 0 0 NA NA NA NA NA hypothetical protein ? Rv2439c proB 54 25.7 25.1 16.6 3 45.3694000809793 -1.15999170288114 0.528814621344877 -2.19356964815205 0.0282663624270514 0.09068791278679 Probable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK) I.D.1 - Glutamate family Rv2440c obg 86.1 44 61.6 53.8 13.2 136.57120379921 -0.261225009984177 0.36945652944794 -0.707052086410578 0.479534109801697 0.668441486390244 Probable GTP1/Obg-family GTP-binding protein Obg I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2441c rpmA 357 268 352.7 233.5 411.6 223.836905996217 1.24214737836067 0.903761428155383 1.37441955328404 0.16931146924392 0.337669608142997 50S ribosomal protein L27 RpmA II.A.1 - Ribosomal protein synthesis and modification Rv2442c rplU 186.6 170.5 205.5 311.4 281.5 191.671583737887 1.66328196031684 0.440185877758215 3.77859001017394 0.000157718844807779 0.00132379182063781 50S ribosomal protein L21 RplU II.A.1 - Ribosomal protein synthesis and modification Rv2443 dctA 13.9 4.6 6.7 17.4 0.4 19.9486575205868 0.594318699594344 0.798528292756389 0.744267554431733 0.456714626050953 0.650871212827001 Probable C4-dicarboxylate-transport transmembrane protein DctA III.A.3 - Carbohydrates, organic acids and alcohols Rv2444c rne 1004.3 535.5 578 750.2 245.2 3428.52694332985 0.249302769670316 0.234030881594871 1.06525586696666 0.286760158355677 0.483018240837741 Possible ribonuclease E Rne II.B.1 - RNA Rv2445c ndkA 132.8 65.8 44.5 153.3 50.3 73.4567468798245 1.12771756526995 0.407370477640733 2.76828495722388 0.00563521604827715 0.0253335582232402 Probable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2446c - 78.7 21.8 21.3 58 10.2 23.7606169792302 0.525377753216214 0.673148716103477 0.780477984504471 0.435109581134918 0.630072827628732 Probable conserved integral membrane protein VI - Unknowns Rv2447c folC 86.8 41.1 38.7 62.6 12.4 125.703102318063 0.128257656644624 0.360372221500638 0.355903282751765 0.721912997284169 0.849224787904526 Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) I.G.2 - Folic acid Rv2448c valS 76.9 35.9 32.5 80 23.2 254.966569794144 0.85581927514402 0.289406351773991 2.95715442974232 0.00310492568199143 0.0156438787562072 Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2449c - 74.8 39.9 56.6 53.8 11 107.752216123549 -0.198634965915453 0.404390669702697 -0.491195719380684 0.623288026242944 0.780875094382658 hypothetical protein V - Conserved hypotheticals Rv2450c rpfE 65.8 3.3 14 6.8 3.8 13.3593999805779 -1.66048114561446 1.05171507469464 -1.5788317440411 0.114374655317311 0.257052683460605 Probable resuscitation-promoting factor RpfE V - Conserved hypotheticals Rv2451 - 4.3 2.1 0.3 8.2 0 1.48077217565248 2.02333125581139 2.51936338174112 0.80311211573341 0.421909935523375 NA Hypothetical proline and serine rich protein VI - Unknowns Rv2452c - 96 23.1 83.9 176 50.7 26.3490251391844 1.39451787001863 0.652288859635223 2.1378839289061 0.032526164916399 0.10120570930454 Hypothetical protein VI - Unknowns Rv2453c mobA 122 23.8 66.3 146 38 94.366724755475 1.08652863277545 0.455643612223409 2.38460192050868 0.0170976112153396 0.0616697952390355 Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA VI - Unknowns Rv2454c - 311.9 149.6 183 372.3 166.6 577.71342131971 1.18522153835536 0.283921195709818 4.17447360839772 2.98675839421491e-05 0.000327526261062205 Probable oxidoreductase (beta subunit) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2455c - 331.7 182.5 157.2 401.1 113.1 923.713628554105 0.932388810409207 0.235873752548325 3.95291464326105 7.72049833886282e-05 0.000717742916437063 Probable oxidoreductase (alpha subunit) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2456c - 91.4 37.7 50.9 75 29.4 142.980967144293 0.60102155321416 0.350681076182074 1.71386936460212 0.0865527205636985 0.20988176752288 Probable conserved integral membrane transport protein II.C.5 - Other membrane proteins Rv2457c clpX 1217.3 848.8 608.4 1094.7 409.1 2139.04343274279 0.562016318824554 0.230169486155993 2.44174989574274 0.0146162686101626 0.0542102863007287 Probable ATP-dependent CLP protease ATP-binding subunit ClpX II.B.3 - Proteins, peptides and glycopeptides Rv2458 mmuM 15.3 9.5 3.7 12.3 0 11.2623563468621 0.0553679440712889 0.961375950051679 0.0575923956370165 0.954073307023011 0.979515261876958 Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (cysteine methyltransferase) V - Conserved hypotheticals Rv2459 - 55.7 53.2 25 128.6 35.1 191.110941643489 1.60083519092628 0.335318927919943 4.77406748511518 1.80541838614677e-06 2.80473329988239e-05 Probable conserved integral membrane transport protein III.A.6 - Efflux proteins Rv2460c clpP2 527 290.1 321.6 339.5 211.8 458.22944824516 0.491770414877498 0.319669996762046 1.53836900509484 0.123958416235465 0.271192532616441 Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) II.B.3 - Proteins, peptides and glycopeptides Rv2461c clpP1 427.6 235.3 239.5 413.7 148.2 355.168144596368 0.677152620881884 0.27148426171616 2.49426105440268 0.0126219676464745 0.0482276261098304 Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) II.B.3 - Proteins, peptides and glycopeptides Rv2462c tig 341.2 228.2 197.4 218.9 97.5 597.577106560707 0.141678042930483 0.266007158076902 0.532609888977212 0.594303655242878 0.759338299809773 Probable trigger factor (TF) protein Tig III.D - Protein and peptide secretion Rv2463 lipP 153.7 103.6 54.1 82.9 22.3 174.51543212963 -0.216420142975914 0.335012916736933 -0.646005369237321 0.518275878185276 0.701655105911572 Probable esterase/lipase LipP II.B.5 - Esterases and lipases Rv2464c - 40 24.6 21.3 13.8 4.5 29.2466547216695 -0.893523284673611 0.588816940960885 -1.51748909128783 0.129143245624182 0.279770872171775 Possible DNA glycosylase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2465c rpiB 69.6 61.4 46.9 23.2 8.6 36.0328086404654 -1.23585223708667 0.564489497159148 -2.18932724755062 0.0285730632997792 0.0914474129089676 Ribose-5-phosphate isomerase I.B.5 - Pentose phosphate pathway Rv2466c - 10.6 10.8 9.3 13.3 12.6 16.8142590347065 1.17516142033056 0.784237466585318 1.49847650794775 0.13400949170468 0.287325435604102 hypothetical protein V - Conserved hypotheticals Rv2467 pepN 44.6 20.3 18.4 31.4 9.5 118.928068882635 0.324929639321506 0.34984158786063 0.92879077444318 0.352997526460396 0.553482620063179 Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase) II.B.3 - Proteins, peptides and glycopeptides Rv2468c - 90.9 69.7 40 55.8 8 44.7295266209135 -0.379228976268538 0.521683415044037 -0.726933165464971 0.467266899053572 0.659649006156936 hypothetical protein VI - Unknowns Rv2468A - 157 136.3 67.1 123.7 26.5 42.5692595663287 0.0606040075909478 0.512059526470603 0.118353442242671 0.905787614128423 0.953325419995372 hypothetical protein ? Rv2469c - 28.4 14.3 10.3 26.3 8.5 21.6371116621122 0.728833226851071 0.647219531080497 1.1260989383839 0.260123643351929 0.454280392538752 hypothetical protein V - Conserved hypotheticals Rv2470 glbO 347.8 266.7 163.5 220.6 18 130.377904254314 -0.591151165170772 0.441276938784607 -1.33963756818781 0.180363203790087 0.352953849626789 Globin (oxygen-binding protein) GlbO I.B.6.a - aerobic Rv2471 aglA 213.3 102 105.3 73.3 22 293.371911099803 -0.802618254770176 0.291192056652013 -2.75631919358755 0.0058455920985454 0.0261758371846369 Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidase) (acid maltase) II.A.8 - Polysaccharides (cytoplasmic) Rv2472 - 175.9 144.4 108.6 57.1 20.1 52.8158083245863 -1.15664514435825 0.48239658693991 -2.39770590355011 0.0164981055666945 0.0598732478660165 hypothetical protein VI - Unknowns Rv2473 - 38.4 48.4 28.4 12.9 5.5 34.2269294096036 -1.40098000024243 0.609659600884716 -2.29797086474055 0.0215634474211041 0.0738662773361226 Possible alanine and proline rich membrane protein II.C.5 - Other membrane proteins Rv2474c - 149.1 100 67.7 30.1 1.5 70.950554709466 -2.09058864167911 0.549053630058943 -3.80762192839828 0.00014030956430016 0.00120303209139981 hypothetical protein VI - Unknowns Rv2475c - 187.5 78 93.5 65.6 27.8 66.7852726780798 -0.604975504145875 0.438494908918755 -1.37966369013868 0.167690217514595 0.33538043502919 hypothetical protein V - Conserved hypotheticals Rv2476c gdh 220.4 109.2 115.7 109.4 27.7 1009.08521181902 -0.41952391898683 0.254804008127358 -1.64645729896502 0.0996696445598425 0.232487594610968 Probable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase) VI - Unknowns Rv2477c - 215.7 126.1 121.8 201.7 73.2 496.526186425997 0.609346980082097 0.257359128308689 2.3676913427808 0.0178994617333219 0.063935046972589 Probable macrolide-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2478c - 50.7 35.7 18 18.3 19.4 28.4474734768214 0.10450786190095 0.659268451327538 0.158520951048859 0.874046312836606 0.935276396979876 hypothetical protein VI - Unknowns Rv2479c - 6 3.5 4.7 4.3 2 7.13993208622541 -0.0409664142963975 1.08303072153662 -0.0378257176659531 0.96982663930946 NA Probable transposase IV.B.1.a - IS6110 Rv2480c - 8.2 10.5 3.4 9 0 3.00282064466004 0.174465521434418 1.67167468141852 0.104365713839952 0.916879130451478 NA Possible transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2481c - 8.9 8.1 3.2 24.4 0 4.38653196219179 1.65599403346879 1.4127783323717 1.17215418408123 0.241135159040557 NA Hypothetical protein VI - Unknowns Rv2482c plsB2 96.6 51 50.3 137.1 30.8 338.171766593655 1.01286388401127 0.286456219531811 3.53584183183981 0.000406477983557688 0.00292037528957673 Probable glycerol-3-phosphate acyltransferase PlsB2 (GPAT) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2483c plsC 67.1 36.2 43 122.3 37 225.565453622419 1.42020066723334 0.30440578254944 4.66548518014002 3.07889686936097e-06 4.6209545386765e-05 Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoserine phosphohydrolase) (PSP) (pspase) + 1-acyl-SN-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (lysophosphatidic acid acyltransferase) (LPAAT) IV.H - Miscellaneous transferases Rv2484c - 91.6 43.5 53.9 156.7 52.4 252.391216395425 1.48647059866274 0.298758958157379 4.97548461084037 6.50846052993572e-07 1.11907607752584e-05 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv2485c lipQ 8.5 6.8 3.4 15.3 6.2 21.5172860436382 1.61838618344555 0.654150256398624 2.47402820317683 0.0133599149646935 0.0502877989425552 Probable carboxylesterase LipQ II.B.5 - Esterases and lipases Rv2486 echA14 36 11.6 18.5 33.7 5.1 28.2287214977802 0.480250288002366 0.621926212278487 0.772198178049005 0.43999706047125 0.633906393910052 Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2487c PE_PGRS42 2.3 1.3 1.7 1.6 0 4.3094746119352 -0.400748552673444 1.42015989948939 -0.2821855150378 0.777801264517942 NA PE-PGRS family protein PE_PGRS42 IV.C.1.b - PE_PGRS subfamily Rv2488c - 13.3 9.6 8.2 8.3 2.9 53.9680757131145 -0.145649954274903 0.453921306565651 -0.320870494881336 0.748308534271074 0.866745856242036 Probable transcriptional regulatory protein (LuxR-family) I.J.1 - Repressors/activators Rv2489c - 9 0 0 8.2 0 1.4220035314606 1.23692941827792 2.54564203945015 0.485900766529252 0.627037524900774 NA Hypothetical alanine rich protein VI - Unknowns Rv2490c PE_PGRS43 3 1.4 1.5 0.7 0 9.67996433463477 -1.7126829705715 1.05299384673611 -1.62648905867796 0.103845659041287 0.239629343657025 PE-PGRS family protein PE_PGRS43 IV.C.1.b - PE_PGRS subfamily Rv2491 - 6 5.5 1.7 6 2.9 4.77361579741785 0.814596271795633 1.30719147417536 0.623165227044892 0.533175949874212 NA hypothetical protein VI - Unknowns Rv2492 - 7.9 0.9 2.8 10 8.2 11.1466222600032 2.24919627858598 0.994619573779201 2.26136337739648 0.0237367646210832 0.0792418664353221 Hypothetical protein VI - Unknowns Rv2493 vapB38 135.3 57 45.4 58.4 24.6 24.9696556009833 -0.15258757767829 0.626432013904494 -0.24358202373347 0.807554551999474 0.898777505608312 Possible antitoxin VapB38 V - Conserved hypotheticals Rv2494 vapC38 54.8 32.7 25.5 22.1 13.6 22.8936421647713 -0.365059459429209 0.650925968069958 -0.560830996667158 0.57491275380159 0.744821734549478 Possible toxin VapC38 Contains PIN domain V - Conserved hypotheticals Rv2495c bkdC 226.4 94.8 135.4 242.7 75.3 366.393316764762 0.801319082703011 0.300885501334991 2.66320271049173 0.00774007713479291 0.0330703898811055 Probable branched-chain keto acid dehydrogenase E2 component BkdC I.B.2 - Pyruvate dehydrogenase Rv2496c bkdB 162.2 76.2 77.5 199.5 59.7 241.686406233364 1.04762784435104 0.291471125820897 3.59427659052163 0.000325294129828045 0.00242057102489693 Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB I.B.2 - Pyruvate dehydrogenase Rv2497c bkdA 163.2 75.9 91.9 212.2 92.1 306.774055540763 1.31306596773373 0.300387087964371 4.37124636958254 1.23539298745269e-05 0.000156277212912765 Probable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA I.B.2 - Pyruvate dehydrogenase Rv2498c citE 44.7 37.9 26.2 34.5 11.6 48.8651134885848 0.1028876710906 0.472690590094128 0.217663886793499 0.827691003186718 0.90792243211129 Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) I.B.3 - TCA cycle Rv2499c - 56.8 56.7 37 76.8 21.1 53.8233414605801 0.645722424433789 0.465840974315485 1.38614346963065 0.165703099075564 0.332858198963511 Possible oxidase regulatory-related protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2500c fadE19 171.2 155.4 85.1 177.5 71.6 320.277532754434 0.665436787368821 0.303413149520295 2.19317056106796 0.0282950927212686 0.0906979352205733 Possible acyl-CoA dehydrogenase FadE19 (MMGC) I.A.3 - Fatty acids Rv2501c accA1 35.7 28.4 18.3 39 10.4 99.8161619356858 0.571624829577073 0.369638977777392 1.5464408894706 0.121998125416572 0.268914331114019 Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.A.3 - Fatty acids Rv2502c accD1 31.8 21.5 15 32.1 4.3 58.1070602529463 0.290565494961059 0.47703196415642 0.609111164017895 0.54245075818671 0.721739622007198 Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD1 I.A.3 - Fatty acids Rv2503c scoB 34.5 23.6 19.5 53.8 8.9 34.7038557701206 0.967889981423385 0.542010511202157 1.78574024196809 0.0741413263805252 0.185720352220523 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (beta subunit) ScoB (3-oxo-acid:CoA transferase) (OXCT B) (succinyl CoA:3-oxoacid CoA-transferase) I.A.3 - Fatty acids Rv2504c scoA 37.8 25.7 14.7 37.8 10.1 35.2754153433498 0.632916548319735 0.528108238593213 1.19845990285195 0.230738024033931 0.415070635412993 Probable succinyl-CoA:3-ketoacid-coenzyme A transferase (alpha subunit) ScoA (3-oxo acid:CoA transferase) (OXCT A) (succinyl-CoA:3-oxoacid-coenzyme A transferase) I.A.3 - Fatty acids Rv2505c fadD35 5.4 4.7 1.3 7.9 2.3 13.7870077341239 1.27050538295522 0.80981040863443 1.5688923844504 0.11667301668386 0.261058638720299 Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2506 - 32.9 7.5 11.6 15.5 4.2 15.315437799445 -0.011306016076708 0.801667287523614 -0.0141031276349479 0.988747705212493 0.996155108273772 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv2507 - 128.7 93.5 62 36 41.5 119.6960959522 -0.250491984738419 0.458273461882903 -0.546599368222688 0.584654003225251 0.7535824160931 Possible conserved proline rich membrane protein II.C.5 - Other membrane proteins Rv2508c - 14.7 5.2 4 2.8 1.5 11.3414745015938 -1.24624020223593 0.937162255297326 -1.32980195818978 0.183583530597161 0.356439287665299 Probable conserved integral membrane leucine and alanine rich protein II.C.5 - Other membrane proteins Rv2509 - 160.9 119 91.2 51 24.5 130.191115366412 -0.949243951679193 0.361108762354045 -2.62869265617132 0.00857137886064139 0.0354119507653853 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2510c - 26.1 26.7 15.6 8.7 3.7 46.5880040481231 -1.12381852713865 0.522296741106636 -2.1516858879064 0.0314221023609726 0.0983189810623365 hypothetical protein V - Conserved hypotheticals Rv2511 orn 25.2 19.4 3.3 24.5 0 14.410036284105 0.27220546645194 0.935824766812147 0.290872261672661 0.771149016480724 0.880635712788115 Oligoribonuclease Orn V - Conserved hypotheticals Rv2512c - 1.8 4.1 1.8 2.6 0 4.31312848694639 -0.308578455063272 1.46354456723175 -0.210843224027635 0.833009608723351 NA Transposase for insertion sequence element IS1081 IV.B.1.b - IS1081 Rv2513 - 146.7 84 71 84.9 52.4 75.0439355601662 0.304306628558966 0.424793083798246 0.716364366947875 0.473766391380933 0.663395108793737 Hypothetical protein VI - Unknowns Rv2514c - 14.5 3.7 2.3 4.5 2.2 2.7770146738849 -0.581470842087742 1.77922982940219 -0.326810416776293 0.743811280239586 NA hypothetical protein VI - Unknowns Rv2515c - 7.6 0.3 5.6 8.4 0 8.51405273946377 0.430188975760204 1.19888028067906 0.358825633128723 0.719725535486489 0.848914653385803 hypothetical protein VI - Unknowns Rv2516c - 97.3 63 43.1 184.8 60.9 155.253226131432 1.64086863419452 0.317469320829859 5.16858961333752 2.35867185896475e-07 4.44383815130487e-06 Hypothetical protein VI - Unknowns Rv2517c - 259.2 165.1 141 537.3 90.4 116.627918401081 1.35457624353955 0.374674758223383 3.61533894079928 0.000299954914478568 0.00228481786469481 hypothetical protein VI - Unknowns Rv2518c ldtB 45.9 21.9 23.3 48.6 11.6 70.7732004239601 0.703937242232884 0.410655228084617 1.71418064130389 0.0864955550943885 0.20988176752288 Probable L,D-transpeptidase LdtB II.C.1 - Lipoproteins(lppA-lpr0) Rv2519 PE26 95.7 82.3 49.1 67 33 194.039208325036 0.25348761480464 0.335377193230265 0.755828422210568 0.449752073542977 0.64349198451521 PE family protein PE26 IV.C.1.a - PE subfamily Rv2520c - 19.2 22.2 4.1 19.1 0 4.17430521500964 0.165826997567482 1.46278718512966 0.113363720473654 0.909742201120371 NA Possible conserved membrane protein V - Conserved hypotheticals Rv2521 bcp 91.6 39.7 56.9 82.9 27.5 55.7454691561627 0.567659694494246 0.454424068802892 1.24918492101366 0.2115974458945 0.391986481881967 Probable bacterioferritin comigratory protein Bcp III.F - Detoxification Rv2522c - 29.5 17.7 12.7 14.2 2.9 36.5896727381892 -0.491276878018766 0.541298591270961 -0.907589426503505 0.364095182734317 0.56537708778823 hypothetical protein V - Conserved hypotheticals Rv2523c acpS 157.3 64 68.8 137.8 26.4 63.561176698372 0.444316466211448 0.448202732573821 0.991329222068648 0.32152484840832 0.520494064470872 holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase) I.H.1 - Synthesis of fatty and mycolic acids Rv2524c fas 526.8 212.1 221.9 483.3 132.6 5552.392753048 0.701386147103846 0.248106574539901 2.82695510348536 0.00469929159115888 0.0217012918068902 Probable fatty acid synthase Fas (fatty acid synthetase) I.H.1 - Synthesis of fatty and mycolic acids Rv2525c - 140.5 68.7 54.3 55.6 12.3 80.4357399947973 -0.630249314134123 0.412321900709197 -1.52853708000979 0.126379244468441 0.275298452587464 Conserved hypothetical protein Secreted; predicted to be a substrate of the twin arginine translocation (tat) export system VI - Unknowns Rv2526 vapB17 214.4 122.9 138.7 95.5 54.6 55.2418151549758 -0.320116203617971 0.475308224520594 -0.67349182510117 0.500634447823996 0.686356542085852 Possible antitoxin VapB17 V - Conserved hypotheticals Rv2527 vapC17 92.7 71.7 37.8 52.5 56.6 56.617490997755 0.761191753445104 0.533932286292607 1.42563349882901 0.153974161435509 0.316895107382088 Possible toxin VapC17 V - Conserved hypotheticals Rv2528c mrr 1.9 0 2.6 1.4 0 1.6606186216584 -0.250642418161275 2.21098940181214 -0.113362107460057 0.909743479875822 NA Probable restriction system protein Mrr II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2529 - 2.4 1.2 0.8 2.1 0 2.31736179323299 0.401957343817967 1.85618801274903 0.216549908229751 0.828559126762829 NA Hypothetical protein VI - Unknowns Rv2530c vapC39 123.1 69.8 48 34 6.3 38.0422345404061 -1.22732578225195 0.553795013864863 -2.21620952071526 0.02667715614404 0.0868478741380419 Possible toxin VapC39 Contains PIN domain V - Conserved hypotheticals Rv2530A vapB39 150.3 56 52.1 132.1 8.3 28.5544066946463 0.301165900456041 0.664881893588295 0.45296150092264 0.65057646409711 0.80178908692831 Possible antitoxin VapB39 ? Rv2531c - 101.8 60.8 51.2 77.4 28.2 353.165532061151 0.354540950883317 0.265370879182712 1.33602056101721 0.181542552930368 0.354204893095119 Probable amino acid decarboxylase I.A.2 - Amino acids and amines Rv2532c - 129.9 70.7 87.4 77.9 33.3 62.020184575073 -0.0310418369416865 0.444570250817097 -0.0698243683301643 0.944333451387731 0.975168829392228 Hypothetical protein VI - Unknowns Rv2533c nusB 184.4 102.9 102.3 116.3 30.7 91.7451730433089 -0.0933935491604335 0.378477909731502 -0.246760898744892 0.805093273098948 0.897686131592986 N utilization substance protein NusB (NusB protein) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2534c efp 239.3 130.4 111.2 211 87.4 178.002756193229 0.719821019606084 0.310904893919623 2.31524505944952 0.0205995245818556 0.0711839181160317 Probable elongation factor P Efp II.A.6 - Protein translation and modification Rv2535c pepQ 133.7 68 47.8 108.3 34.3 167.044795616035 0.578283230313451 0.320462360586007 1.80452777435698 0.0711486091168354 0.180392536500953 Probable cytoplasmic peptidase PepQ II.B.3 - Proteins, peptides and glycopeptides Rv2536 - 91.2 67.9 56.3 67.3 20.3 78.1460568652854 -0.0128154648302077 0.399591167520905 -0.032071441693058 0.974415077917576 0.99017882337715 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv2537c aroD 233 144.8 103.9 91 15.8 86.4459313959337 -0.902361347515731 0.420164195740683 -2.14763979573512 0.0317423814435933 0.0991459568546804 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) I.D.4 - Aromatic amino acid family Rv2538c aroB 169.4 85.9 97.7 57.9 21 167.372668853821 -0.821905304813165 0.334117454739976 -2.4599292648533 0.0138964401536556 0.0519210875783209 3-dehydroquinate synthase AroB I.D.4 - Aromatic amino acid family Rv2539c aroK 180.5 101.6 71.4 84.7 11.3 78.8481122133765 -0.587830304942189 0.436897061494517 -1.34546637354659 0.178474673404751 0.350031723809318 Shikimate kinase AroK (SK) I.D.4 - Aromatic amino acid family Rv2540c aroF 411.2 207 176.6 145.9 28.3 389.455459012164 -0.924502075767717 0.299279191488382 -3.08909574090321 0.00200766729044064 0.0111111836605324 Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) I.D.4 - Aromatic amino acid family Rv2541 - 56.1 12.7 21 4.5 4.8 12.4139459425488 -2.34533447107658 1.00313608934347 -2.33800228701925 0.0193871295046743 0.0681385125008204 Hypothetical alanine rich protein VI - Unknowns Rv2542 - 87.6 54.1 65.7 25.2 11.3 106.602025616315 -1.21680437966169 0.402523259412967 -3.02294178337981 0.00250330395810655 0.0133333873979149 hypothetical protein V - Conserved hypotheticals Rv2543 lppA 14.2 7 10.4 6.7 4.3 10.4955995438144 -0.229194150481603 0.927302308916193 -0.247162277369372 0.804782638030266 0.897686131592986 Probable conserved lipoprotein LppA II.C.1 - Lipoproteins(lppA-lpr0) Rv2544 lppB 20.4 13 15.9 3.1 4.7 13.7528570352617 -1.70364744372658 0.93381154878468 -1.82440177136791 0.0680913544076368 0.174641258010029 Probable conserved lipoprotein LppB II.C.1 - Lipoproteins(lppA-lpr0) Rv2545 vapB18 20.4 0 13.8 2.8 0 3.19233931996184 -2.0143957769355 1.7911883564577 -1.12461415332066 0.26075257356176 NA Possible antitoxin VapB18 V - Conserved hypotheticals Rv2546 vapC18 2 0 1.1 1.5 0 0.343648880559981 1.05981212668465 4.41472330823807 0.240063091769985 0.810281346138096 NA Possible toxin VapC18 V - Conserved hypotheticals Rv2547 vapB19 54.8 68.3 20.2 32.8 15.3 18.4790824898203 -0.242828374725626 0.751930395229359 -0.322939963946472 0.746740709624481 0.865495940278113 Possible antitoxin VapB19 V - Conserved hypotheticals Rv2548 vapC19 32 30 3.3 4.7 0 7.5063212776172 -2.21583903981933 1.27761543013993 -1.73435525866859 0.0828550684198755 0.20380045301611 Possible toxin VapC19 V - Conserved hypotheticals Rv2548A - 257.7 186.4 115.4 328.1 116 154.619330514688 1.04019445379322 0.321545108984014 3.23498764164045 0.00121647995971521 0.00735285327186224 hypothetical protein ? Rv2549c vapC20 34.3 29 12 26.3 2.5 12.629746734348 -0.261746549331972 0.918039323145946 -0.285114746975125 0.775556232301439 0.881423631580758 Possible toxin VapC20 VI - Unknowns Rv2550c vapB20 72.1 37.7 32.8 18.7 8 13.4512511683227 -1.26459519351369 0.844974444107124 -1.49660762208018 0.134495385683488 0.287932213412871 Possible antitoxin VapB20 VI - Unknowns Rv2551c - 53.7 28.4 31.7 16.8 0 17.100011288737 -1.43148146827956 0.828801915642897 -1.7271695941595 0.0841372098253182 0.206095433749154 hypothetical protein VI - Unknowns Rv2552c aroE 148.7 93.3 80.2 17.5 1.4 88.4517130158666 -2.7241699471168 0.475096270417244 -5.73393250324688 9.81283947535809e-09 2.41368593206377e-07 Probable shikimate 5-dehydrogenase AroE (5-dehydroshikimate reductase) I.D.4 - Aromatic amino acid family Rv2553c - 311.7 184 152 120.9 19.5 331.813331028054 -0.992334806838221 0.319110806536675 -3.10968725129706 0.00187285531725959 0.0104466984783204 Probable conserved membrane protein VI - Unknowns Rv2554c - 191.1 91.9 81.7 69.1 15.1 76.6983954533845 -0.798708672708491 0.420653583278688 -1.89873260197415 0.057599642713675 0.156215876333719 hypothetical protein VI - Unknowns Rv2555c alaS 591.3 327.8 369.4 378.1 156.4 1938.26119687551 0.137742652305251 0.2557600483527 0.538562035753527 0.590189089121303 0.757409331039006 Probable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2556c - 1041.8 565 435.3 373.9 151.6 358.347445696853 -0.527505350301547 0.277911327503356 -1.89810669122574 0.0576820289097134 0.156319622339866 hypothetical protein V - Conserved hypotheticals Rv2557 - 403.9 241.5 225 1950 600.8 1086.86547867008 2.87095169031263 0.236470738982693 12.1408327417742 6.41696151227617e-34 4.54577553529644e-31 hypothetical protein V - Conserved hypotheticals Rv2558 - 339.7 133.4 163.6 1171 282.7 646.918917887588 2.46821574745315 0.283428644294783 8.70842025722022 3.08138995995774e-18 4.19780124545012e-16 hypothetical protein V - Conserved hypotheticals Rv2559c - 21.5 10.9 8.6 7.6 3.1 24.1762388070786 -0.624111544089498 0.634118045433245 -0.984219812989378 0.325007446093501 0.524685545441952 Conserved hypothetical alanine leucine valine rich protein V - Conserved hypotheticals Rv2560 - 5.4 7.1 5.8 9 10.1 19.0105127337766 1.67351376662704 0.782873371287156 2.13765575379777 0.0325446930824028 0.10120570930454 Probable proline and glycine rich transmembrane protein II.C.5 - Other membrane proteins Rv2561 - 44.9 38.1 21.9 58.8 10.1 18.0213083280612 0.654189846064152 0.715034103871755 0.914907194666457 0.36024035271371 0.561360021694659 hypothetical protein VI - Unknowns Rv2562 - 27.3 24.2 12.6 26 14.1 16.3237199893571 0.689510764465286 0.743703067192176 0.927131801497752 0.353858106423569 0.554169218212823 hypothetical protein VI - Unknowns Rv2563 - 18.3 18.4 5.3 5.4 0 15.1226930318377 -1.53327171812766 0.911336039001317 -1.68244385441828 0.0924828035558382 0.220886102626284 Probable glutamine-transport transmembrane protein ABC transporter II.C.5 - Other membrane proteins Rv2564 glnQ 24.2 13.4 6.5 13.7 2 18.5163555215841 -0.212093531932919 0.746121923652754 -0.28426122488746 0.776210198990252 0.881762836697714 Probable glutamine-transport ATP-binding protein ABC transporter GlnQ III.A.1 - Amino acids Rv2565 - 46.5 37.9 28.4 25.3 9.6 97.2032502773957 -0.36047428932507 0.381581203070482 -0.944685656485251 0.344819381980925 0.545732909283484 hypothetical protein V - Conserved hypotheticals Rv2566 - 19.3 11.4 7.3 3.9 0.9 46.1672707863341 -1.65298448228268 0.527147778581603 -3.13571364510037 0.00171436507560505 0.00969144278295025 Long conserved protein VI - Unknowns Rv2567 - 65.9 43.6 33.6 10.2 2.5 134.821355217038 -2.17332714345122 0.373934399638554 -5.8120545891257 6.17107086861836e-09 1.6191061493812e-07 Conserved hypothetical alanine and leucine rich protein V - Conserved hypotheticals Rv2568c - 16.6 8.4 8.3 16.3 6.7 22.6572396753014 0.780986963406239 0.629977378672877 1.23970636064978 0.215084023649136 0.396991981117895 hypothetical protein V - Conserved hypotheticals Rv2569c - 13.9 10.9 7.5 12.9 2.1 15.1981694951725 0.0574438966424254 0.785245496326381 0.0731540606232898 0.94168352270058 0.973691654363404 hypothetical protein V - Conserved hypotheticals Rv2570 - 16.4 4.4 2.5 6.8 15.2 9.33555586583838 1.88209214363253 1.14876879453377 1.63835590989951 0.101347470880429 0.234990650958649 hypothetical protein VI - Unknowns Rv2571c - 15.1 11.6 8.3 6.6 1.8 15.4552416068805 -0.814362141069469 0.785507128961504 -1.03673424599738 0.299859727205218 0.496078072751462 Probable transmembrane alanine and valine and leucine rich protein V - Conserved hypotheticals Rv2572c aspS 30.1 21 11.5 18.7 4.4 53.7093092150245 -0.123835499193971 0.466405762418017 -0.265510225585471 0.790616433580622 0.891551546559237 Probable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2573 - 6.8 7 3.2 0.9 0 3.99066758803698 -2.71462052466649 1.57112867232629 -1.72781553317787 0.0840213016247252 NA hypothetical protein VI - Unknowns Rv2574 - 103 68.1 63.5 35.9 5.8 46.5080173603105 -1.21968654582157 0.524898413401507 -2.32366209285644 0.0201436116517325 0.0698401194582221 hypothetical protein VI - Unknowns Rv2575 - 53.5 20.1 19.4 35.2 6 39.9192134116781 0.119958534527724 0.53738354497391 0.223227033372501 0.823358813135191 0.906045859973057 Possible conserved membrane glycine rich protein V - Conserved hypotheticals Rv2576c - 1240 827.9 464.7 447.5 143.9 504.653975751842 -0.725101852514218 0.275939122858459 -2.62776022842602 0.00859490738315002 0.0354402351002531 Possible conserved membrane protein VI - Unknowns Rv2577 - 6.2 4.3 3.4 5.8 1.2 11.0976736853947 0.242575761064693 0.881580442059745 0.275160098263902 0.783193241068482 0.885336132396263 hypothetical protein VI - Unknowns Rv2578c - 14.2 10.1 8.3 7 6.7 19.530876586035 0.0626684554081052 0.723763916000009 0.0865868745632581 0.93099989929469 0.968441588895881 hypothetical protein VI - Unknowns Rv2579 dhaA 51.9 26.8 19.3 37.5 9.9 47.304159048323 0.284559710131322 0.475582515410331 0.59833930161584 0.549613557697297 0.726392246777547 Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2580c hisS 157.5 84.4 87.4 76.4 30.5 206.416127613874 -0.254993438630591 0.309235011143977 -0.824594335833043 0.409601938209503 0.606019241912306 Probable histidyl-tRNA synthetase HisS (histidine--tRNA ligase) (HISRS) (histidine--translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2581c - 144.4 90.6 102.1 73 23.7 107.812508751176 -0.520272022744168 0.377367596624642 -1.37868759108554 0.167991097067884 0.335792587931402 Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II) III.F - Detoxification Rv2582 ppiB 26.3 20.7 18.3 16.2 22 46.6288513109131 0.862189360299866 0.589848053664621 1.4617143431147 0.143819505115146 0.302678958477627 Probable peptidyl-prolyl cis-trans isomerase B PpiB (cyclophilin) (PPIase) (rotamase) (peptidylprolyl isomerase) II.A.6 - Protein translation and modification Rv2583c relA 145 82.9 58.8 193.8 38.8 467.303506287976 0.940880664019945 0.285889061778387 3.29106912369137 0.000998073851096403 0.00616959438147201 Probable GTP pyrophosphokinase RelA (ATP:GTP 3'-pyrophosphotransferase) (PPGPP synthetase I) ((P)PPGPP synthetase) (GTP diphosphokinase) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2584c apt 131.1 52.6 73.1 85.6 30.6 95.5900620197772 0.204092154245031 0.388916167701675 0.52477158625502 0.599741986047133 0.763033805524047 Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) I.F.4 - Salvage of nucleosides and nucleotides Rv2585c - 92.9 48.9 61.4 59.5 8.4 157.674517432327 -0.435347022897045 0.389097705581051 -1.11886299161525 0.263198593432432 0.456761106289895 Possible conserved lipoprotein V - Conserved hypotheticals Rv2586c secF 239.6 147.2 106 74.9 23.7 270.527945575076 -0.974781723202245 0.288653074333285 -3.37700100874984 0.000732807813556455 0.00479779163699993 Probable protein-export membrane protein SecF III.D - Protein and peptide secretion Rv2587c secD 241.9 162 148.9 95.9 30.2 419.331734459859 -0.821254547606829 0.272729653715785 -3.01124038555291 0.00260182785770391 0.0137469426155321 Probable protein-export membrane protein SecD III.D - Protein and peptide secretion Rv2588c yajC 311.3 235.4 196.8 181.3 63.9 128.572236291403 -0.296429830659896 0.348450342359458 -0.850708966599613 0.39493104102148 0.594614104267602 Probable conserved membrane protein secretion factor YajC V - Conserved hypotheticals Rv2589 gabT 111.7 72.5 56.3 58.3 18.5 156.114361557453 -0.30502051271024 0.320186421229857 -0.952634129638091 0.340775478467767 0.542496362932164 4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at) I.C.1 - General Rv2590 fadD9 870 522.3 464.6 333.5 98.1 2830.66675826816 -0.798049909125306 0.223219730595113 -3.57517638336751 0.00034999185736725 0.00258264824748916 Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv2591 PE_PGRS44 93.3 69.6 45.6 12.5 1.2 115.030749111535 -2.63355459036103 0.461961140207879 -5.700814118642 1.19236598299673e-08 2.89271254231124e-07 PE-PGRS family protein PE_PGRS44 IV.C.1.b - PE_PGRS subfamily Rv2592c ruvB 72 35 23.5 11 2.9 46.2995132193144 -1.88416886928551 0.537942057954926 -3.50254984049488 0.000460827559249768 0.00323218062349045 Probable holliday junction DNA helicase RuvB II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2593c ruvA 63.9 32.1 34.3 22.5 5 30.9726635050573 -0.959339606565889 0.590421250930348 -1.62483922293485 0.10419682112598 0.240223249291264 Probable holliday junction DNA helicase RuvA II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2594c ruvC 98.9 75.2 54.4 52.1 0 51.4462913027465 -1.25198352361951 1.17825466695014 -1.06257463580452 0.287974894555461 0.484333844499261 Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2595 vapB40 216.3 173.8 89.1 83 40.1 54.0037249468076 -0.589213252011989 0.478729506014236 -1.23078532785165 0.218403164493375 0.401653171669539 Possible antitoxin VapB40 V - Conserved hypotheticals Rv2596 vapC40 64.3 50.1 26.7 24 7.2 23.2313161814575 -0.865020806550493 0.659033776907959 -1.31255913863623 0.18933154607515 0.364661411744526 Possible toxin VapC40 Contains PIN domain V - Conserved hypotheticals Rv2597 - 46.4 47.1 30.7 29.9 10.9 37.9687290847408 -0.323535949902213 0.538008208274254 -0.60135876168136 0.547601059161152 0.725085215532262 Probable membrane protein VI - Unknowns Rv2598 - 16.1 12.7 13.9 10.7 0 8.61907578351336 -0.752152816050707 1.068872648011 -0.703687962686989 0.481627118281164 0.669542764321112 hypothetical protein VI - Unknowns Rv2599 - 19 17.5 5 8.8 3.4 7.80819101015468 -0.425810606001633 1.0739429336823 -0.396492767582749 0.691741542263437 0.829715050015948 Probable conserved membrane protein V - Conserved hypotheticals Rv2600 - 99.7 56.9 38.8 14.2 4 27.0081524883224 -2.11229503207215 0.664471990337201 -3.17890755786443 0.00147831229584209 0.00855585318933445 Probable conserved integral membrane protein V - Conserved hypotheticals Rv2601 speE 14.1 6.6 9.5 1.2 1.3 17.0135991541196 -2.85387400734591 0.899226407099927 -3.17369906489943 0.00150509652882246 0.00868249495942858 Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) I.E - Polyamine synthesis Rv2601A vapB41 157 71.9 66.5 76.2 7.6 34.4473623875088 -0.604164355541049 0.608048959970157 -0.993611362431573 0.320412110277998 0.519404894555913 Possible antitoxin VapB41 ? Rv2602 vapC41 147.7 72.9 50.8 63.7 13.2 50.2843055946624 -0.515872206211883 0.493314156094497 -1.04572755482222 0.29568683706926 0.491239576406811 Possible toxin VapC41 Contains PIN domain V - Conserved hypotheticals Rv2603c - 115.6 73 72.4 114.5 40.3 125.642983525831 0.569647744751908 0.342433555559804 1.66352781584345 0.0962068276446957 0.227631652316307 Highly conserved protein V - Conserved hypotheticals Rv2604c snoP 66.5 25.7 39.1 27.4 6 33.7375330122771 -0.644829890178071 0.578351433762877 -1.11494474213139 0.26487410188933 0.458545488217013 Probable glutamine amidotransferase SnoP V - Conserved hypotheticals Rv2605c tesB2 185.3 132.2 90.9 128.7 54.7 196.802126218369 0.251388862148709 0.311170513292016 0.807881375035024 0.419158874067167 0.614454883197863 Probable acyl-CoA thioesterase II TesB2 (TEII) I.H.1 - Synthesis of fatty and mycolic acids Rv2606c snzP 178.7 92.2 62.7 155.9 29.4 166.948221981168 0.436706940062564 0.346644949889192 1.25981047813378 0.207737738964897 0.388493701907954 Possible pyridoxine biosynthesis protein SnzP V - Conserved hypotheticals Rv2607 pdxH 2.4 0 4.2 8.4 2.9 4.72891019059696 1.8645910957687 1.38573871182478 1.3455574848691 0.178445270615129 NA Probable pyridoxamine 5'-phosphate oxidase PdxH (PNP/PMP oxidase) (pyridoxinephosphate oxidase) (PNPOX) (pyridoxine 5'-phosphate oxidase) I.G.6 - Pyridoxine Rv2608 PPE42 27.1 10.2 13.8 28.9 7.4 57.6721085988369 0.789258303633031 0.453321954106091 1.74105466652145 0.0816739966591984 0.201644542363387 PPE family protein PPE42 IV.C.2 - PPE family Rv2609c - 144 100.2 66.9 32 7.2 121.796301184561 -1.66609950355878 0.3787225488095 -4.39926143504288 1.0861991011954e-05 0.000138892318282819 Probable conserved membrane protein V - Conserved hypotheticals Rv2610c pimA 120.3 76 56.7 43 20.6 130.802380442174 -0.610670764043829 0.351466316349309 -1.73749442161879 0.0822999378119003 0.202716536668811 Alpha-mannosyltransferase PimA IV.H - Miscellaneous transferases Rv2611c - 72.1 32.7 31.2 19.9 5.5 50.9431100758589 -1.08839244790307 0.484023670825885 -2.24863475384573 0.0245357434034658 0.0812961675725688 Probable acyltransferase V - Conserved hypotheticals Rv2612c pgsA1 58.6 31.5 39.3 25.3 1.7 33.8779353695995 -0.99583757772608 0.615304461903884 -1.61844686554806 0.105566328999796 0.242330484327464 PI synthase PgsA1 (phosphatidylinositol synthase) (CDP-diacylglycerol--inositol-3-phosphatidyltransferase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2613c - 102.9 55.6 61.7 54.5 25.3 67.4180366832462 -0.110681607391464 0.429064470357958 -0.257960318408851 0.796437532300494 0.894413994739489 hypothetical protein V - Conserved hypotheticals Rv2614c thrS 68.3 50.6 41 32.6 27.1 190.642264563886 0.147136487535269 0.386802692449007 0.380391580533442 0.703654763516071 0.837568933784111 Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2614A - 1 0 0 0 0 0.0493734785565507 0.514412337427994 4.4620599203744 0.115285842549786 0.908218559547373 NA hypothetical protein ? Rv2615c PE_PGRS45 34 21.2 12 4.1 1.4 31.0709433825989 -2.33462532338358 0.64539056164935 -3.61738373957196 0.000297595931124306 0.0022717344569877 PE-PGRS family protein PE_PGRS45 IV.C.1.a - PE subfamily Rv2616 - 72.3 23.6 36.5 49.3 11.8 35.0618040103573 0.217904496087222 0.554822314754744 0.392746452859499 0.694506757434665 0.830500653218631 hypothetical protein VI - Unknowns Rv2617c - 54.4 25.6 14 39 2.2 17.4694201823972 0.0124300724982384 0.82534032753359 0.0150605417953874 0.987983880475061 0.996155108273772 Probable transmembrane protein VI - Unknowns Rv2618 - 20.4 7.9 7.8 13.7 0.4 10.3806992549598 -0.119084662415169 0.97906109239458 -0.121631493009197 0.903190870843498 0.952113709680854 hypothetical protein V - Conserved hypotheticals Rv2619c - 54.2 48.2 49.1 18.8 15.6 25.3526431389883 -0.938646520762976 0.683426195828585 -1.37344240898604 0.169614853401216 0.337855433184778 hypothetical protein VI - Unknowns Rv2620c - 25.1 27 9.7 13.4 2.9 11.3941962337604 -0.560889185759365 0.910751050896597 -0.615853459852934 0.537991240278568 0.717456691666675 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2621c - 62.5 26.2 34.3 21.4 0 30.817769543603 -1.25449848288703 0.684417768327541 -1.83294259871797 0.06681110786075 0.172607544888969 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv2622 - 15.5 6 2.6 4.9 0 6.46649184182047 -0.829156135934908 1.24117314911371 -0.668042276395514 0.504106606673919 NA Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2623 TB31.7 2430.4 941.3 2260.1 8336.7 2145.9 6372.75753875585 2.07296441058075 0.357718219298469 5.79496458035068 6.83356017465504e-09 1.76674964515534e-07 Universal stress protein family protein TB31.7 V - Conserved hypotheticals Rv2624c - 300.3 128.9 228.2 1233.1 327 819.217217457392 2.47413455000738 0.314302681354074 7.87182132633532 3.49515095904435e-15 3.2578486044566e-13 Universal stress protein family protein V - Conserved hypotheticals Rv2625c - 505.1 182.1 389.2 2396.6 587 2158.52716358114 2.66957781171527 0.337723552912596 7.90462432570158 2.68742839396324e-15 2.57266793822102e-13 Probable conserved transmembrane alanine and leucine rich protein V - Conserved hypotheticals Rv2626c hrp1 1433 671.7 1306.2 7926.1 3847.7 3500.44501322823 3.20192421325762 0.340443356074796 9.40515993666258 5.19511355671123e-21 9.68478537782693e-19 Hypoxic response protein 1 Hrp1 V - Conserved hypotheticals Rv2627c - 828.4 268.5 764.6 3490.9 781.8 3340.34696068457 2.33261158965848 0.678870110382298 3.43602046103473 0.000590326387145529 0.00397516361838301 hypothetical protein V - Conserved hypotheticals Rv2628 - 406.8 148.4 411.6 2124 649.7 644.318255587823 2.74500392235129 0.381417715673411 7.19684432461365 6.16220489840813e-13 3.71648283548185e-11 Hypothetical protein VI - Unknowns Rv2629 - 1584.2 630 1195.6 4527.6 1439 4787.4444754579 2.09978034183641 0.313598434624036 6.69576155363712 2.14551323764899e-11 9.15591311777436e-10 hypothetical protein VI - Unknowns Rv2630 - 733.5 328.7 476.7 1775.7 459 869.171837101675 1.78422141720398 0.287862121489821 6.19818060108014 5.71195773998808e-10 1.82268056892232e-08 Hypothetical protein VI - Unknowns Rv2631 - 311.6 136.5 202.9 489.6 105.2 639.486481802524 1.06376892673745 0.30876625425321 3.44522405568676 0.000570586219122559 0.00387911014996565 hypothetical protein V - Conserved hypotheticals Rv2632c - 92 62.2 28.3 542.3 203 130.812329006036 3.45961216887303 0.367822292567246 9.40566202425194 5.1703681973829e-21 9.68478537782693e-19 hypothetical protein V - Conserved hypotheticals Rv2633c - 128.4 69.7 63.1 324.7 168.3 183.192529632667 2.41921794715398 0.334969897438504 7.22219508574832 5.11550132788565e-13 3.17879047427561e-11 Hypothetical protein VI - Unknowns Rv2634c PE_PGRS46 7.5 2.8 4.4 8.3 1.5 19.5851431552594 0.596373909060887 0.707217058832277 0.84326855752828 0.399078263566727 0.598875057980804 PE-PGRS family protein PE_PGRS46 IV.C.1.b - PE_PGRS subfamily Rv2635 - 0 0 0 1.5 0 0.0854208528060269 2.09694716487919 4.43926588087807 0.472363499089273 0.636667353215063 NA Hypothetical protein VI - Unknowns Rv2636 - 7.2 2.5 4.7 10.3 0 5.24139492615855 0.706794372959411 1.31081417573784 0.5392025704647 0.589747086911924 NA hypothetical protein VI - Unknowns Rv2637 dedA 23.1 20.7 8.8 10.6 6 16.9801589140586 -0.331105335803843 0.755799047206268 -0.438086468920197 0.661323602780958 0.810241508491924 Possible transmembrane protein DedA V - Conserved hypotheticals Rv2638 - 22 8.4 8.7 18.2 5.3 10.3506290512671 0.672001499342948 0.903295334719486 0.74394439283984 0.456910117038338 0.650871212827001 hypothetical protein V - Conserved hypotheticals Rv2639c - 58.7 35 14.2 33.3 20.3 20.6314794394126 0.40901829923992 0.695489646969411 0.588101204701196 0.556464364567746 0.731081891431363 Probable conserved integral membrane protein V - Conserved hypotheticals Rv2640c - 242.3 139.2 159.4 69 54.3 91.6315217587107 -0.714442104469455 0.446360398425038 -1.60059473687704 0.10946670873979 0.248386343597909 Possible transcriptional regulatory protein (probably ArsR-family) I.J.1 - Repressors/activators Rv2641 cadI 245.2 175 104.1 136.7 60.4 125.906217864935 -0.00125291394271029 0.353990584447474 -0.0035393990624522 0.997175974029809 0.999433305040629 Cadmium inducible protein CadI V - Conserved hypotheticals Rv2642 - 38.2 11.2 28.3 19.9 0 11.8833832923312 -0.715640018059421 0.967481518472969 -0.739693735120601 0.459485850351515 0.652503806127907 Possible transcriptional regulatory protein (probably ArsR-family) I.J.1 - Repressors/activators Rv2643 arsC 11.4 3.5 6.5 6.4 2.6 17.0732556624012 0.0537417180999122 0.743186733351604 0.0723125369280331 0.942353187791572 0.973691654363404 Probable arsenic-transport integral membrane protein ArsC III.A.4 - Anions Rv2644c - 17.8 13.7 17.3 3.7 0 5.34955255365197 -2.38830292433331 1.38053465886341 -1.72998403843015 0.0836331270443832 NA Hypothetical protein VI - Unknowns Rv2645 - 47.4 19.4 23.6 36.3 24.4 27.5086897772341 0.826953293019317 0.608832031472855 1.35826180337259 0.174380625869815 0.344272339275188 Hypothetical protein VI - Unknowns Rv2646 - 18.8 9.9 13.2 16.1 8.2 26.476560396376 0.512925751285717 0.607707715771813 0.844033633231529 0.398650611540365 0.598567387060607 Probable integrase IV.B.3 - Phage-related functions Rv2647 - 50.5 16.3 24.6 29.4 15 18.8259017217328 0.296058974075989 0.713831996936851 0.414746012151904 0.67832784521034 0.820589432842296 Hypothetical protein IV.B.3 - Phage-related functions Rv2648 - 12.7 10.7 9.9 6.5 8.6 6.71771975032953 0.0971909378460177 1.17221138039341 0.0829124673857025 0.933921140636205 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv2649 - 6.5 2.9 1.5 4 4.6 7.94988081357903 1.14585508846912 1.0796456048324 1.06132520091813 0.288542136815178 0.484827442409564 Probable transposase for insertion sequence element IS6110 IV.B.1.a - IS6110 Rv2650c - 98.2 47.7 48.5 53.2 13 132.240240714064 -0.260323479327881 0.348567600875818 -0.746837854906156 0.455161442209289 0.649811297180694 Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2651c - 121.4 60.4 59.7 139.5 40.6 88.8738876632152 0.907117439790386 0.374355301745125 2.42314570025239 0.0153867540872924 0.0564765626706628 Possible PhiRv2 prophage protease IV.B.3 - Phage-related functions Rv2652c - 12.2 13.1 3.4 13 7.8 13.4734677039229 1.02029914044428 0.84542433198463 1.20684856331156 0.227490469693112 0.41089813546813 Probable PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2653c - 4.9 0.4 6.5 1.9 17.5 6.52439034802477 2.38155442150063 1.43739994757365 1.65684883008429 0.0975500418753965 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2654c - 2.7 0 5.2 0 0 0.698909208694134 -1.59056563768064 3.37848164590341 -0.470793037934447 0.63778853673454 NA Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2655c - 2.9 4.6 1.3 5.3 4.2 12.8184795703558 1.80352524855 0.897193956467616 2.01018434815448 0.0444116813494173 0.128441886580864 Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2656c - 6.6 5.1 2.7 22.1 19.9 12.3228459477865 3.1713181320418 0.935347336016204 3.39052457833361 0.00069758999047698 0.00459308823245143 Possible PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2657c - 87.2 25.4 18.5 274.1 17.5 37.9665588148958 2.28701028661201 0.664838936035141 3.439946372953 0.000581829460329237 0.00393290066504992 Probable PhiRv2 prophage protein IV.B.3 - Phage-related functions Rv2658c - 27.6 4.7 15.1 388.6 146 110.889624196589 4.82433003074378 0.439542583542276 10.9757966835988 4.99634643349031e-28 2.21213238342783e-25 Possible prophage protein IV.B.3 - Phage-related functions Rv2659c - 7.7 0 2.3 56.2 52 88.163964692013 5.38775580818474 1.27376120407216 4.22980052380331 2.33898622016739e-05 0.000267248038446223 Probable PhiRv2 prophage integrase IV.B.3 - Phage-related functions Rv2660c - 0.1 0 0 0 0 0 NA NA NA NA NA Hypothetical protein VI - Unknowns Rv2661c - 6 9 3 1.6 3.2 3.36690383960019 -0.545507576730876 1.66063178169507 -0.328494000141353 0.742538180031713 NA Hypothetical protein VI - Unknowns Rv2662 - 11 0 0 48.1 52.5 20.6773837099776 5.09660692108517 1.83401985348326 2.77892679918674 0.00545388138187971 0.0247662151982281 Hypothetical protein VI - Unknowns Rv2663 - 46.5 50.2 84.4 103.9 182.8 70.0488918631636 2.43657012224217 1.05768306116327 2.30368643661777 0.0212402517640499 0.0729708746345924 Hypothetical protein VI - Unknowns Rv2664 - 34.4 28.5 17.6 65.5 43.4 23.948696456553 1.90488944147077 0.653644271784135 2.91426013154118 0.00356532681629473 0.0175151006703411 Hypothetical protein VI - Unknowns Rv2665 - 572.4 325.4 338.5 326.4 173.9 195.343071413038 0.136048221583897 0.333327197042598 0.408152178372982 0.683161954544862 0.823327540999627 Hypothetical arginine rich protein V - Conserved hypotheticals Rv2666 - 4.8 4.5 3.4 5.1 2.5 5.74693665795629 0.433146588497326 1.17975171671511 0.367150632086702 0.713506661504024 NA Probable transposase for insertion sequence element IS1081 (fragment) IV.B.1.b - IS1081 Rv2667 clpC2 5.9 2.3 1.8 2.1 2.6 3.69252787969397 0.0941429259506996 1.50760795724124 0.0624452302062472 0.950208276720754 NA Possible ATP-dependent protease ATP-binding subunit ClpC2 II.B.3 - Proteins, peptides and glycopeptides Rv2668 - 29.2 24.1 12 27.3 3.8 16.5840013994236 0.160422822154502 0.770236709032647 0.208277300047124 0.835012454932408 0.913074326040876 Possible exported alanine and valine rich protein VI - Unknowns Rv2669 - 27.9 18.9 6.7 35.6 11.6 17.9358987936424 1.23729903666136 0.724796584057075 1.70709832783087 0.0878037778829654 0.212142552020098 GCN5-related N-acetyltransferase I.J.1 - Repressors/activators Rv2670c - 8.4 10.9 1.9 4 0 8.51528588910161 -0.99762737231597 1.1406652532064 -0.874601351721415 0.381790852047957 0.582387251487452 hypothetical protein V - Conserved hypotheticals Rv2671 ribD 25.7 17.7 11.5 12.1 5.1 20.022161516412 -0.328081404223026 0.681344053377466 -0.481520903568037 0.630146326722422 0.784685822827163 Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reductase (HTP reductase) I.G.9 - Riboflavin Rv2672 - 49.3 36.4 30.5 18.2 5.6 78.0924823198102 -0.9912248887344 0.413947443929054 -2.39456699943843 0.0166400030226747 0.0603263978570254 Possible secreted protease II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2673 aftC 28.4 19.2 13.2 11.7 7.8 40.0431213196842 -0.256868941972819 0.53369432146464 -0.481303494606955 0.630300813727966 0.784685822827163 Possible arabinofuranosyltransferase AftC II.C.5 - Other membrane proteins Rv2674 msrB 186.7 169.3 109.7 58.3 27.1 81.637369246202 -1.13717975959234 0.427993174505002 -2.65700442748311 0.00788384076206692 0.0334826906225911 Probable peptide methionine sulfoxide reductase MsrB (protein-methionine-R-oxide reductase) (peptide met(O) reductase) V - Conserved hypotheticals Rv2675c - 132.9 80.8 53.6 66.1 22.1 96.4965324177879 -0.214931805669337 0.371650656607571 -0.578316765618648 0.563050277277587 0.73658247083737 hypothetical protein IV.H - Miscellaneous transferases Rv2676c - 168.5 109.2 76.4 95 28.8 121.165739650246 -0.158920119725527 0.343787526026346 -0.462262611917306 0.643893007854638 0.79647685134055 hypothetical protein V - Conserved hypotheticals Rv2677c hemY 77.9 31.9 30.7 35.5 2.9 77.2432884757881 -0.629727980592405 0.484265575579848 -1.30037733910444 0.193471672747363 0.369421382679871 Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) I.G.12 - Heme and porphyrin Rv2678c hemE 96.1 57.4 47.6 40.3 9.2 92.4783283713302 -0.709189996117844 0.387142554850273 -1.83185750890165 0.0669726525514498 0.17285103695939 Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD) I.G.12 - Heme and porphyrin Rv2679 echA15 97.6 49.9 46.6 15.3 4.7 57.9998988930559 -1.94438516653205 0.480065608659571 -4.05024882319965 5.11632009220724e-05 0.000509045105803316 Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2680 - 123 74.4 64.5 61.6 12 73.0593666201957 -0.547069903847791 0.423786858737239 -1.29090813593867 0.196735533883046 0.373639282044906 hypothetical protein V - Conserved hypotheticals Rv2681 - 69.6 45.1 37.9 33.3 3 82.3704157590668 -0.864784877139936 0.46091435956912 -1.87623765496994 0.0606226536303735 0.161084350456701 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2682c dxs1 232.9 150.7 115.3 100.9 35.7 440.314162298168 -0.509643969881911 0.259988457998292 -1.96025613523682 0.0499658602399823 0.140125951678557 Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv2683 - 21.5 22.8 16 21.8 0 13.62210873876 -0.290488422380987 0.891564620085794 -0.325818696521441 0.744561532188615 0.863818194239133 hypothetical protein V - Conserved hypotheticals Rv2684 arsA 39.3 23.2 16.5 30.3 4.7 51.3595914250702 0.110591187538926 0.4798900181092 0.230451110391216 0.81774124934814 0.903581426877352 Probable arsenic-transport integral membrane protein ArsA III.A.4 - Anions Rv2685 arsB1 47.1 26.2 17.3 18.1 3.9 48.0972925159188 -0.685010467439306 0.492476504968555 -1.39095055404327 0.164240421242489 0.331098219715934 Probable arsenic-transport integral membrane protein ArsB1 III.A.4 - Anions Rv2686c - 33 17.1 11.4 26 7.8 26.9066785270344 0.534575899386785 0.591940595167692 0.903090451560167 0.366477891251635 0.567350045263647 Antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter II.C.5 - Other membrane proteins Rv2687c - 17 11.8 5.5 13.2 5.5 14.4589028667029 0.486201027884723 0.779200649864228 0.623974104705176 0.532644591472962 0.712472486026145 Antibiotic-transport integral membrane leucine and valine rich protein ABC transporter VI - Unknowns Rv2688c - 81.2 27.3 25 68.4 7.3 62.5720788011165 0.421174713659332 0.509199339053137 0.827131304692013 0.408162642549486 0.604865709307802 Antibiotic-transport ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv2689c - 11.7 11.3 4.2 4.8 0 12.1907671571451 -1.18379792445008 0.953336813407953 -1.24174154170999 0.21433193752368 0.395952397712513 Conserved alanine and valine and glycine rich protein IV.H - Miscellaneous transferases Rv2690c - 10.7 7.4 9 12.8 14.1 56.0461442222778 1.58814791488873 0.547957623351303 2.89830426151502 0.00375186418751077 0.0181050448939553 Probable conserved integral membrane alanine and valine and leucine rich protein II.C.5 - Other membrane proteins Rv2691 ceoB 62.6 40.1 22 32.8 13 42.3719429792523 -0.0683114535791585 0.502519371025534 -0.135937950888837 0.891870333459773 0.944396030228555 TRK system potassium uptake protein CeoB III.A.2 - Cations Rv2692 ceoC 56.5 25.6 29.6 31 4.4 32.4253326809612 -0.39539503546841 0.589227965271407 -0.671039154236824 0.502195586764861 0.687051667949455 TRK system potassium uptake protein CeoC III.A.2 - Cations Rv2693c - 70.7 29.2 31.2 72 23.6 60.163906617457 0.896742641344356 0.433171313278991 2.0701801200921 0.0384354802044698 0.115371585495112 Probable conserved integral membrane alanine and leucine rich protein V - Conserved hypotheticals Rv2694c - 123.8 65.5 45 237.8 74.1 85.9273480746491 1.79639488587375 0.385306489689045 4.6622492326135 3.12772083949578e-06 4.63787047396702e-05 hypothetical protein V - Conserved hypotheticals Rv2695 - 16.5 4.4 4.5 15 0 8.75207050923614 0.448858177259302 1.06276355183609 0.422349991664496 0.672769573727232 0.817591999101511 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2696c - 224.7 86.7 85.7 74.6 21.7 130.011144901965 -0.665566167513692 0.364106412111932 -1.82794409923516 0.0675579416905898 0.173776491988431 Conserved alanine and glycine and valine rich protein V - Conserved hypotheticals Rv2697c dut 491.7 305.5 240.5 97.7 41.8 186.708644767181 -1.53771745474467 0.327204443409138 -4.69956165241283 2.60720505918294e-06 3.96312882628966e-05 Probable deoxyuridine 5'-triphosphate nucleotidohydrolase Dut (dUTPase) (dUTP pyrophosphatase) (deoxyuridine 5'-triphosphatase) (dUTP diphosphatase) (deoxyuridine-triphosphatase) I.F.3 - 2'-deoxyribonucleotide metabolism Rv2698 - 26 13.8 11 29.3 11.1 17.3857358987839 1.02436882267216 0.706547530140828 1.44982294746397 0.147107898628039 0.305847027028212 Probable conserved alanine rich transmembrane protein V - Conserved hypotheticals Rv2699c - 27.7 0 15.9 49.6 20.4 15.4887279857176 2.01588731014137 0.83729534697967 2.40761795394322 0.0160569742854994 0.0584520071112423 hypothetical protein V - Conserved hypotheticals Rv2700 - 59 38.1 21.8 46.9 3 35.0639612373996 -0.0662513228887158 0.616595524384811 -0.107446973370129 0.914434390809993 0.95801370906451 Possible conserved secreted alanine rich protein V - Conserved hypotheticals Rv2701c suhB 21.9 9.9 8.6 11.2 0 13.6725818872626 -0.524023966450985 0.882951175297105 -0.593491442235926 0.552852308475468 0.729040534854843 Inositol-1-monophosphatase SuhB III.B - Chaperones/Heat shock Rv2702 ppgK 100.9 74.4 35.1 55.4 32.9 94.8081393293247 0.25227498662259 0.41744765690744 0.604327231086906 0.545626105287847 0.723823095479234 Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase) I.A.1 - Carbon compounds Rv2703 sigA 371.6 175.2 201.2 433.5 174.9 912.524162860922 1.12602544368808 0.261301088014303 4.30930254537037 1.63770202012661e-05 0.000199338163411975 RNA polymerase sigma factor SigA (sigma-A) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2704 - 116.4 71.2 46 157.8 52.1 77.0576518773038 1.21176397165895 0.392665455038 3.08599586775895 0.00202871641530896 0.0111752932239881 hypothetical protein V - Conserved hypotheticals Rv2705c - 36.7 37.5 20.5 14 19.3 21.3844881911015 -0.0551349570752592 0.755646256357737 -0.0729639783316246 0.941834782204099 0.973691654363404 hypothetical protein VI - Unknowns Rv2706c - 9.5 3.9 5.7 4.9 9.5 4.47978439999251 1.11446017037637 1.42766457872321 0.780617651362517 0.435027406950011 NA Hypothetical protein VI - Unknowns Rv2707 - 128.4 91.5 52.8 76.7 11.8 119.807593292563 -0.388908295615746 0.393451450945488 -0.98845307262478 0.322930806237594 0.522531254314097 Probable conserved transmembrane alanine and leucine rich protein V - Conserved hypotheticals Rv2708c - 595.3 391.5 242.8 407.4 200.5 183.749077214198 0.451301101327223 0.328649692592913 1.37319800230647 0.169690800574737 0.337855433184778 hypothetical protein V - Conserved hypotheticals Rv2709 - 236.1 145.7 110.2 73.7 49.7 102.481510277571 -0.556771271805402 0.404014374797405 -1.37809767804573 0.168173132375977 0.335966855541855 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2710 sigB 537.4 296.7 281.1 304.8 84.9 531.035178313584 -0.212542792002539 0.256690795696437 -0.8280109593563 0.407664293341858 0.604865709307802 RNA polymerase sigma factor SigB II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2711 ideR 685.3 427.7 383.2 243.2 81.9 448.650259732716 -0.860506322412812 0.263997246388872 -3.25952764350153 0.00111597904587292 0.00680343852062285 Iron-dependent repressor and activator IdeR I.J.1 - Repressors/activators Rv2712c - 21.7 16.7 9.1 30 13.1 40.8479222505617 1.23980197348313 0.502734014084413 2.46611913805172 0.0136585896101972 0.0511944173537762 Hypothetical protein VI - Unknowns Rv2713 sthA 95.4 54.5 40.7 124.8 39.6 204.161300002988 1.15073574907729 0.29483485699334 3.90298406644396 9.50139597780281e-05 0.000865139962811762 Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleotide transhydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2714 - 139.5 84.3 70.4 66.1 23 136.351304254417 -0.361227823642412 0.332915795659112 -1.08504260942995 0.277902783847588 0.473919913523427 Conserved alanine and leucine rich protein V - Conserved hypotheticals Rv2715 - 248.2 183.1 120.9 106.4 36.6 255.919159199522 -0.604222935433387 0.294781922697624 -2.04972859225556 0.0403909232438267 0.119650302974289 Possible hydrolase II.B.6 - Aromatic hydrocarbons Rv2716 - 128.5 120.7 87.1 26.3 18.1 94.8292928618912 -1.62330938069239 0.449557504731123 -3.61090486446953 0.000305130581302103 0.00230934298925652 hypothetical protein V - Conserved hypotheticals Rv2717c - 32.8 18.1 3.4 23.6 3.5 12.3560715104208 0.347559522987931 0.933538045691731 0.372303544126471 0.709666860160188 0.842090458521737 hypothetical protein V - Conserved hypotheticals Rv2718c nrdR 78.1 50.2 20.5 99.1 15.2 43.8723129477962 0.942873570621849 0.530071484096206 1.77876682468495 0.0752779982931303 0.188168433277535 Probable transcriptional regulatory protein NrdR V - Conserved hypotheticals Rv2719c - 61.4 21.8 37.7 21.8 6.6 24.9950811530003 -0.866547603539031 0.661465258021887 -1.31004250492375 0.19018145685045 0.365465068627432 Possible conserved membrane protein V - Conserved hypotheticals Rv2720 lexA 1409.5 824.8 501.9 273.7 56.5 698.722512334161 -1.74928926829067 0.289392980594684 -6.04468451410256 1.49702642468679e-09 4.38220462499223e-08 Repressor LexA I.J.1 - Repressors/activators Rv2721c - 102.4 64.2 41.1 93.4 25 258.821116307851 0.518081421898077 0.290595337629718 1.78282771541994 0.0746143526731711 0.186641269186703 Possible conserved transmembrane alanine and glycine rich protein V - Conserved hypotheticals Rv2722 - 17.1 7 6.7 24.1 11.8 6.49776843175943 1.69881789037119 1.13874940553378 1.49182768580668 0.135744323991342 NA hypothetical protein VI - Unknowns Rv2723 - 29 16.8 13.2 26.9 14.8 52.0440173655519 0.967353657720255 0.469872985095414 2.05875563908791 0.0395176532334039 0.117821151307 Probable conserved integral membrane protein III.A.2 - Cations Rv2724c fadE20 86.3 87.3 42.2 69.1 21 133.509621344091 0.0519149777142392 0.368496229823517 0.14088333478772 0.887962107741061 0.943076997187058 Probable acyl-CoA dehydrogenase FadE20 I.A.3 - Fatty acids Rv2725c hflX 115.2 80.7 66.7 38.7 16.6 170.532418083314 -0.9120736124078 0.33030915150739 -2.76127260854108 0.00575765950825915 0.0258147214914606 Probable GTP-binding protein HflX II.B.3 - Proteins, peptides and glycopeptides Rv2726c dapF 102 53.9 67.7 56.3 13.3 90.8405748114233 -0.436062276002229 0.404725032704921 -1.07742847801597 0.281288887253799 0.478083127952474 Probable diaminopimelate epimerase DapF (DAP epimerase) I.D.2 - Aspartate family Rv2727c miaA 39.4 14.9 10.4 23.3 3.9 28.7425322663694 0.120089481192739 0.616246213330055 0.194872566508445 0.845492711198937 0.915606208783323 Probable tRNA delta(2)-isopentenylpyrophosphate transferase MiaA (IPP transferase) (isopentenyl-diphosphate:tRNA isopentenyltransferase) (iptase) (IPPT) I.F.5 - Miscellaneous nucleoside/nucleotide reactions Rv2728c - 31.5 9.9 8.8 19.6 3.3 15.5150944162735 0.116987857704385 0.809234341776761 0.144566106089277 0.885053459472685 0.941399205240916 Conserved alanine rich protein V - Conserved hypotheticals Rv2729c - 71.5 55.5 35.6 41.7 10 68.4672861014672 -0.363042908463231 0.42799620423902 -0.848238617229616 0.396305094755784 0.596056325106152 Probable conserved integral membrane alanine valine and leucine rich protein V - Conserved hypotheticals Rv2730 - 11.8 3.1 1.6 19.5 0 5.09277286528295 1.54764747415891 1.37552403353318 1.12513299399329 0.260532681847151 NA Hypothetical protein VI - Unknowns Rv2731 - 48.7 20.7 22.2 65.1 11.1 83.7659942918102 0.970443671141967 0.416394073457134 2.33058953765793 0.019775013693831 0.0688045631915934 Conserved alanine and arginine rich protein VI - Unknowns Rv2732c - 75.4 15 17.8 43.5 12.8 34.9226028610278 0.469366918621947 0.606872465866314 0.773419367365635 0.439274231647876 0.633771620568952 Probable conserved transmembrane protein V - Conserved hypotheticals Rv2733c - 68.1 37.2 34 34.7 6.4 95.4053563299946 -0.480816203350056 0.393099892241756 -1.2231400029343 0.221276821756664 0.405045221014007 Conserved hypothetical alanine, arginine-rich protein V - Conserved hypotheticals Rv2734 - 8.3 5.2 0.9 16.6 1.4 9.4512862714863 1.63675794180062 1.01437130020855 1.61356885931622 0.10662097600285 0.243560477924416 hypothetical protein VI - Unknowns Rv2735c - 47.3 31.7 27.1 18.8 10.3 49.9473012213212 -0.531332144571592 0.483547910194483 -1.09882006181743 0.271846559757569 0.467524974319816 hypothetical protein VI - Unknowns Rv2736c recX 135.2 72.1 91 32 12 62.3109150806726 -1.47958996306243 0.470715000414032 -3.14328194716763 0.00167064835716183 0.00948307128376154 Regulatory protein RecX II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2737c recA 256.3 145 107.9 99 33.2 536.926952222106 -0.565618026817399 0.254095755597604 -2.22600344302143 0.026013950797812 0.0850797910672669 RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)] II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2737A - 4.9 2.5 3.8 1.3 0 0.460544931099306 -1.047364495413 3.97249754708454 -0.263653906138136 0.79204661658992 NA Conserved hypothetical cysteine rich protein (fragment) ? Rv2738c - 44.5 7.6 16.8 23.7 9.6 6.78847613712004 0.217603977529299 1.14509308021511 0.1900316937453 0.849284295007876 NA hypothetical protein V - Conserved hypotheticals Rv2739c - 27.6 10.5 12.9 6.7 3.4 24.1702290374901 -1.0262599825035 0.665231243592296 -1.54271163958208 0.122900756497791 0.269906518364127 Possible alanine rich transferase IV.H - Miscellaneous transferases Rv2740 ephG 98.2 65 37.4 63.7 19.5 46.5004977262931 0.0828959819728004 0.478745402639156 0.173152538939954 0.862531528486547 0.926740289848456 Epoxide hydrolase V - Conserved hypotheticals Rv2741 PE_PGRS47 55.6 30.3 37.1 47.1 13.5 111.507409534408 0.271651002544055 0.36662302582021 0.740954559349665 0.458720992782601 0.652348817472152 PE-PGRS family protein PE_PGRS47 IV.C.1.b - PE_PGRS subfamily Rv2742c - 22.9 20.7 6.4 28.8 11.5 31.0952273454027 1.15234405608961 0.583706291132569 1.97418474598536 0.0483607398429835 0.136706895868992 Conserved hypothetical arginine rich protein V - Conserved hypotheticals Rv2743c - 99.5 49.3 44.6 70.5 22.1 87.1062344563231 0.300320754123824 0.37871302240294 0.793003504918538 0.427775780739664 0.622506908537342 Possible conserved transmembrane alanine rich protein V - Conserved hypotheticals Rv2744c 35kd_ag 227.8 153.1 111.6 296.1 63.7 264.930179486967 0.790480365889045 0.29856684424936 2.64758254680431 0.00810695648915761 0.0341031352548649 Conserved 35 kDa alanine rich protein V - Conserved hypotheticals Rv2745c clgR 147.2 73.3 107 102.5 30.6 58.2985237671528 -0.0446800256555502 0.461472504020704 -0.0968205586817489 0.922868897169643 0.963395706977565 Transcriptional regulatory protein ClgR I.J.1 - Repressors/activators Rv2746c pgsA3 55.9 27.4 25.2 46.1 18.6 42.1806306790174 0.611758391188396 0.490615205773255 1.246920975929 0.212426474672366 0.393316556868541 Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase) (phosphatidylglycerophosphate synthase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2747 argA 27.9 23 10.2 24.6 7.5 17.8709294945698 0.436867065667141 0.709737539717412 0.615533265777492 0.538202607452911 0.717468436431393 Probable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase) V - Conserved hypotheticals Rv2748c ftsK 213.6 109.6 82.5 108.2 37.2 531.616222748681 -0.0715116589628241 0.258840408716405 -0.276277028449507 0.78233529818178 0.885336132396263 Possible cell division transmembrane protein FtsK III.C - Cell division Rv2749 - 98.8 26.3 28.3 49.5 12.5 22.6819004608287 0.0618732047266192 0.676536582865677 0.0914558152414115 0.927130413374599 0.966135900021426 hypothetical protein V - Conserved hypotheticals Rv2750 - 88.2 53.2 36.6 67.1 12 73.9483094643347 0.115828024192844 0.421505310138206 0.274796120966699 0.783472878438646 0.885336132396263 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2751 - 65.1 25.2 25.2 46.1 22.9 66.4262368703397 0.730535545591422 0.440463138194092 1.65856227739427 0.0972040284414839 0.228476149307272 hypothetical protein V - Conserved hypotheticals Rv2752c - 169.4 102.2 72.2 111.8 29.7 296.653290202946 0.04658059625422 0.280532248002843 0.166043642347129 0.868122605223044 0.931345086505122 hypothetical protein V - Conserved hypotheticals Rv2753c dapA 327.2 209.8 122.6 194.9 65.3 306.283269444931 0.0388266679278493 0.287333714941348 0.135127435135047 0.892511119008234 0.944792105058925 Probable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase) I.D.2 - Aspartate family Rv2754c thyX 9.5 10.3 5.2 3.3 0 6.72976742023896 -1.50155514487889 1.22533763576034 -1.22542154999357 0.220416431500669 NA Probable thymidylate synthase ThyX (ts) (TSase) V - Conserved hypotheticals Rv2755c hsdS.1 26.8 33.9 19.6 8.3 0 8.0173539925829 -1.90495343304858 1.1725460359791 -1.6246299715285 0.104241426922832 0.240223249291264 Possible type I restriction/modification system specificity determinant (fragment) HsdS.1 (S protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2756c hsdM 28.6 31.4 10 6.8 3.6 45.8271530320548 -1.36034387849694 0.575810243296933 -2.36248641689314 0.0181528066507256 0.0647504946192046 Possible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2757c vapC21 37 26.8 20.2 11.1 0 12.4124022680247 -1.50073600348755 0.936689906148572 -1.60216950522953 0.109118131471337 0.248072157683875 Possible toxin VapC21 V - Conserved hypotheticals Rv2758c vapB21 32.2 31.6 7.7 12.4 9.4 9.37784068035804 -0.310439669561088 1.02090403534763 -0.304083105573561 0.761064577580346 0.875802258232129 Possible antitoxin VapB21 V - Conserved hypotheticals Rv2759c vapC42 42.1 17.9 29.9 13.6 6.9 15.4672947523498 -0.846706824257272 0.805563644238076 -1.05107377959951 0.293224705543547 0.489214275570062 Possible toxin VapC42 Contains PIN domain V - Conserved hypotheticals Rv2760c vapB42 52.9 31.7 30.9 7.3 0 10.477747060085 -2.49753521101738 1.06190944052144 -2.35192862565662 0.0186763582190359 0.0660196215686878 Possible antitoxin VapB42 V - Conserved hypotheticals Rv2761c hsdS 65.9 41.4 29.3 17.6 8.8 62.7141574402542 -0.994749126340969 0.452108559477627 -2.2002439579784 0.0277895910512605 0.0895639049168015 Possible type I restriction/modification system specificity determinant HsdS (S protein) VI - Unknowns Rv2762c - 54.5 49.1 22.1 16.4 10.1 22.317334529332 -0.938584192981904 0.689878610572878 -1.36050629574165 0.173669761972888 0.343592386212569 hypothetical protein VI - Unknowns Rv2763c dfrA 82.3 55.2 46.6 85.1 12.5 48.2689237194837 0.337132189347288 0.490628662070478 0.68714328250733 0.491992441452332 0.680186271516065 Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) I.G.2 - Folic acid Rv2764c thyA 146.7 65.6 57.4 223.2 65.8 182.36592506018 1.46501868142744 0.31412773163316 4.66376742292302 3.10472261758351e-06 4.63787047396702e-05 Probable thymidylate synthase ThyA (ts) (TSASE) I.F.3 - 2'-deoxyribonucleotide metabolism Rv2765 - 3.6 0 0 3.2 0 1.33658267865458 1.13280333782852 2.60522291140601 0.434820119564033 0.663692999810562 NA Probable alanine rich hydrolase VI - Unknowns Rv2766c - 21.5 9.7 11 10.2 1.1 12.6968765744063 -0.758633060987723 0.911369880056859 -0.832409625980171 0.405177770496774 0.603696932605714 Probable short-chain type dehydrogenase/reductase I.H.1 - Synthesis of fatty and mycolic acids Rv2767c - 20.3 0 14.4 13.8 0 5.25315918443326 -0.0850715350031587 1.42492392060314 -0.0597025102695655 0.952392572397656 NA Possible membrane protein VI - Unknowns Rv2768c PPE43 15.3 2.9 17.2 13.6 1.7 20.7873202713232 -0.187490643628859 0.826143367300417 -0.226946860617572 0.820465063071463 0.905041187604834 PPE family protein PPE43 IV.C.2 - PPE family Rv2769c PE27 16.3 9.8 7.3 8.4 3.8 13.0977173204555 -0.161089536667692 0.814748545668571 -0.197716875377181 0.843266585712783 0.914808651330682 PE family protein PE27 IV.C.1.a - PE subfamily Rv2770c PPE44 34.4 18.4 17.8 34.4 6.5 46.400562042108 0.492142631367878 0.485292083230043 1.01411634018886 0.310527241902796 0.50736458873468 PPE family protein PPE44 IV.C.2 - PPE family Rv2771c - 88.2 52.5 50.6 49.1 14.9 41.4152651851994 -0.304090787135869 0.501807394269898 -0.60599104478782 0.54452069987108 0.722928367789082 hypothetical protein VI - Unknowns Rv2772c - 110.7 103 71 56.8 16.3 60.9763318295487 -0.684961347487259 0.457538565514895 -1.49705707696231 0.134378407132637 0.287932213412871 Probable conserved transmembrane protein VI - Unknowns Rv2773c dapB 148.4 87.7 80.2 99.3 29.3 122.043790963727 0.0217809120220116 0.34213973025126 0.063660867464928 0.949240264750117 0.977994521000095 Dihydrodipicolinate reductase DapB (DHPR) I.D.2 - Aspartate family Rv2774c - 12.8 21.3 5.1 5.5 0 5.73553794839345 -1.39923163403779 1.34590715562758 -1.03961973022229 0.298516606658009 NA Hypothetical protein VI - Unknowns Rv2775 - 47 19.7 21.7 61.9 17.3 29.722845226344 1.166115964457 0.570438556690251 2.0442446443714 0.0409293847843678 0.120608885945284 GCN5-related N-acetyltransferase VI - Unknowns Rv2776c - 48.2 23.2 12.7 35.7 17.4 50.6457693711091 0.807973206960113 0.48873505048942 1.65319267801851 0.0982916561726648 0.230562282227536 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2777c - 99.9 60.8 44.6 108.8 33.3 146.94911732557 0.825703122042506 0.319479949934565 2.58452250982143 0.00975139389960973 0.0387648004404239 hypothetical protein VI - Unknowns Rv2778c - 200.6 150.6 93.8 123.7 77.3 124.421461803089 0.338301043415637 0.380191920997876 0.889816497225166 0.373564426816705 0.575039200254138 hypothetical protein V - Conserved hypotheticals Rv2779c - 106.6 98.2 48.5 80.9 13.9 65.9393168826457 -0.156233742920918 0.461695676200359 -0.338391176210881 0.735068422715171 0.858428075587582 Possible transcriptional regulatory protein (probably Lrp/AsnC-family) I.J.1 - Repressors/activators Rv2780 ald 127 105.6 80.3 532.9 184.2 544.014288326362 2.53534394241971 0.268062798973565 9.45802234449448 3.1382223026526e-21 6.53857846823266e-19 Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43) I.A.2 - Amino acids and amines Rv2781c - 140.6 85 77.2 25.9 5.6 113.283968083454 -1.98841965622348 0.398288362055859 -4.99241214571217 5.96298400745995e-07 1.03028728558162e-05 Possible alanine rich oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2782c pepR 254.5 120.3 108.5 68.7 6.1 232.545647329677 -1.5138318802905 0.398218536046516 -3.80151033480187 0.000143816738805932 0.00122451655973705 Probable zinc protease PepR II.B.3 - Proteins, peptides and glycopeptides Rv2783c gpsI 389.1 213.5 215.9 231.3 114.6 1045.73154802413 0.239901890811201 0.26869320892887 0.89284687085154 0.371939182092129 0.57379582709341 Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI: guanosine pentaphosphate synthetase + polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) (pnpase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2784c lppU 205.6 102.1 124.4 309.6 111.1 187.813255851807 1.3199453925197 0.317175950759539 4.16155572122929 3.16086847991981e-05 0.000342379087335657 Probable lipoprotein LppU II.C.1 - Lipoproteins(lppA-lpr0) Rv2785c rpsO 1168.9 636.1 478.8 2793.8 738.8 668.050223031518 1.94627596449688 0.251553820021759 7.73701613566645 1.01777146454547e-14 8.54812403854734e-13 30S ribosomal protein S15 RpsO II.A.1 - Ribosomal protein synthesis and modification Rv2786c ribF 64.9 37.2 25.7 36.6 17.9 70.2407446314802 0.216443620286275 0.422219268031425 0.51263321376931 0.608207915292599 0.768285462184874 Probable bifunctional FAD synthetase/riboflavin biosynthesis protein RibF: riboflavin kinase (flavokinase) + FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)(FAD diphosphorylase) (flavin adenine dinucleotide synthetase) I.G.9 - Riboflavin Rv2787 - 15.3 9 6.7 6.6 3.2 25.7760394435238 -0.360726054024868 0.611616171843139 -0.589791556586544 0.555330404066435 0.730404861196923 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2788 sirR 66.5 37.8 36.8 50.1 5.4 46.2350503666402 -0.123514027551803 0.520235998909145 -0.237419224757211 0.812331576842114 0.90083858646674 Probable transcriptional repressor SirR I.J.1 - Repressors/activators Rv2789c fadE21 140 99.5 65.6 24.5 8.6 139.400042118535 -1.85113456358976 0.360452042145063 -5.13559183233806 2.81257497706579e-07 5.18331336109116e-06 Probable acyl-CoA dehydrogenase FadE21 I.A.3 - Fatty acids Rv2790c ltp1 227 166.1 123.4 47.6 12.2 233.063973344616 -1.8142306315825 0.319918147172789 -5.67092128913408 1.42031645817285e-08 3.39916276678935e-07 Probable lipid-transfer protein Ltp1 III.A.5 - Fatty acid transport Rv2791c - 1191.2 606.3 365.7 958.6 120.4 1524.50195193003 0.144615975372719 0.344951321967861 0.419235892611516 0.675043743035692 0.81911782728072 Probable transposase IV.B.1.c - Others Rv2792c - 277.4 186.4 161.4 82.3 31 151.715225294732 -1.13426888715868 0.339155613021941 -3.34439072687646 0.000824635079686726 0.00524390925000069 Possible resolvase IV.B.1.c - Others Rv2793c truB 106.3 61 72.4 39.5 3 83.9136196888318 -1.31233603322756 0.484958425616673 -2.70607945734481 0.00680827537333052 0.0297714955214033 Probable tRNA pseudouridine synthase B TruB (tRNA pseudouridine 55 synthase) (PSI55 synthase) (pseudouridylate synthase) (uracil hydrolyase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2794c pptT 93.3 69.8 35.7 45.8 8.2 57.9707826836713 -0.601531265493458 0.480741838302844 -1.25125632421974 0.210840974681713 0.391609193666821 Phosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase) V - Conserved hypotheticals Rv2795c - 134.9 79.7 66.8 58.1 21.1 127.135344601763 -0.477081554053831 0.341137927865857 -1.39850047468609 0.161962830221873 0.328359696476486 hypothetical protein VI - Unknowns Rv2796c lppV 40.8 35.1 13.9 11 0 17.6332273753836 -1.63891934341726 0.843380304177101 -1.94327438677428 0.0519830144961957 0.143622338023031 Probable conserved lipoprotein LppV II.C.1 - Lipoproteins(lppA-lpr0) Rv2797c - 19.2 11.7 9.6 4.1 4.7 31.4085050295997 -0.88691403993345 0.639053650374923 -1.38785536928411 0.16518109050486 0.332615930965444 hypothetical protein V - Conserved hypotheticals Rv2798c - 104.4 122.1 49 48.3 17.6 39.0890203077303 -0.781253959625562 0.564521623596543 -1.38392211559271 0.166382304168764 0.333706750490239 hypothetical protein V - Conserved hypotheticals Rv2799 - 67.5 50.3 27 15.3 6.8 35.0461207891986 -1.41833573797358 0.573412194804036 -2.4735011756391 0.0133796363902859 0.0503085691023276 Probable membrane protein VI - Unknowns Rv2800 - 38.7 25 19.1 10.9 4.4 56.1408494417851 -1.08217780913963 0.461547416114895 -2.34467309610123 0.0190437685301557 0.0671174409291655 Possible hydrolase V - Conserved hypotheticals Rv2801c mazF9 18.2 14.3 6.2 21.7 0 6.39003397360573 0.508016131355781 1.184455652167 0.428902619043902 0.667994094157433 NA Toxin MazF9 V - Conserved hypotheticals Rv2801A mazE9 22.9 16.6 7.6 41.4 0 6.16471642997448 1.16349510383191 1.21391699002809 0.958463480937845 0.337829097904172 NA Possible antitoxin MazE9 ? Rv2802c - 17.6 5.7 7.7 10.7 1.9 14.4094177611737 -0.0569331650643427 0.819958182433264 -0.0694342300425503 0.944643983023057 0.975205184455747 Hypothetical arginine and alanine rich protein VI - Unknowns Rv2803 - 14.2 7.4 13.6 4 4.1 7.03400624541582 -1.19107963835727 1.17921457824466 -1.01006183296197 0.312465666659717 NA hypothetical protein ? Rv2804c - 0.5 0 0 0 0 0.0493734785565507 0.514412337427994 4.4620599203744 0.115285842549786 0.908218559547373 NA Hypothetical protein VI - Unknowns Rv2805 - 15 13.2 0 4.4 0 3.75205249783918 -1.17587235247552 1.69029485437714 -0.695661085064843 0.486641101588672 NA hypothetical protein V - Conserved hypotheticals Rv2806 - 9.5 10.9 2.9 1 0 1.1184595234648 -2.32659402425124 2.82558224206703 -0.823403399700459 0.410278630401099 NA Possible membrane protein VI - Unknowns Rv2807 - 1.7 1.7 0.7 0.1 0 1.08149154102739 -2.34365224081114 2.66827624529762 -0.878339431661704 0.37975954300639 NA hypothetical protein V - Conserved hypotheticals Rv2808 - 41.8 60.1 31.5 70.1 65.8 35.7132442496879 1.59344239659134 0.62475863694582 2.55049278611177 0.0107570750241474 0.0422411970460422 Hypothetical protein VI - Unknowns Rv2809 - 204.1 148.7 142.4 168.3 191.1 132.912190570535 1.21995124156684 0.45712085909344 2.66877176418124 0.00761291626332642 0.032645217196976 Hypothetical protein VI - Unknowns Rv2810c - 0 0 0 0 0 0 NA NA NA NA NA Probable transposase IV.B.1.c - Others Rv2811 - 11.9 7 3.5 2 0 4.34189897559696 -1.8401610346922 1.46376661720169 -1.25714100394643 0.208702581607821 NA hypothetical protein V - Conserved hypotheticals Rv2812 - 4 3.7 1.4 0.3 0 4.02868043162233 -3.3492119354579 1.62980557581266 -2.05497636353827 0.0398812877591322 NA Probable transposase IV.B.1.c - Others Rv2813 - 1.9 2.1 1.3 0.5 0 1.06816543672032 -1.24023766838571 2.48880801775684 -0.498325969515132 0.618254306528161 NA hypothetical protein III.D - Protein and peptide secretion Rv2814c - 4.5 3.2 4.1 3 0 4.81181051459106 -0.693075537663639 1.36905037231443 -0.506245461583689 0.612684344178755 NA Probable transposase IV.B.1.a - IS6110 Rv2815c - 12.5 4.1 6.8 6.3 0 2.78469518278732 -0.486844506197143 1.71337695056664 -0.284143256413095 0.77630059865984 NA Probable transposase IV.B.1.a - IS6110 Rv2816c - 22.1 17.4 5 19.6 16.1 11.5262804402211 1.24072061891046 0.909507000270481 1.36416830056446 0.172514602470318 0.342035980326859 hypothetical protein V - Conserved hypotheticals Rv2817c - 13.6 19.4 9 7 0 16.5754471566485 -1.30016775619918 0.869711220401862 -1.49494191370605 0.134929602277493 0.288251297507165 hypothetical protein V - Conserved hypotheticals Rv2818c - 52.8 42.3 40.9 26.8 12.7 77.5183492702478 -0.45580246716348 0.430207261358579 -1.05949505762425 0.289374378919307 0.485534841370054 Hypothetical protein VI - Unknowns Rv2819c - 43.9 15.3 24.4 33.1 18.8 64.9565424231705 0.786686373834401 0.465973488033048 1.68826423399137 0.0913605176458635 0.218821599985213 Hypothetical protein VI - Unknowns Rv2820c - 48.3 19.9 24.3 33.8 12.9 47.8815388731894 0.343762753242226 0.476783567710799 0.72100377723324 0.47090719076601 0.661623669057202 Hypothetical protein VI - Unknowns Rv2821c - 46.1 23.5 21.3 33.6 35.2 55.0641700398404 1.24028062114188 0.530761858150653 2.33679304964269 0.0194499474107817 0.0682772187601473 hypothetical protein V - Conserved hypotheticals Rv2822c - 36.6 51.2 29.6 30.6 23.7 27.5385125522282 0.267823360002017 0.65700273636091 0.40764420782396 0.683534903530274 0.823496812348378 Hypothetical protein VI - Unknowns Rv2823c - 23.7 19.8 17 15.3 15.1 101.037796553198 0.600162071523882 0.462661309153037 1.29719529091931 0.19456400060035 0.370907260563207 hypothetical protein V - Conserved hypotheticals Rv2824c - 34.9 23.4 14.7 22.9 16.8 45.3008608898846 0.615616334501282 0.518370541763385 1.18759899512632 0.234991433931902 0.420775448049506 Hypothetical protein VI - Unknowns Rv2825c - 171.2 91.8 78.4 55.1 9.1 86.8590792091914 -1.08424873267653 0.415007136275053 -2.61260262271231 0.00898557110991552 0.0364987303570193 hypothetical protein V - Conserved hypotheticals Rv2826c - 100.2 45.4 50.5 52.3 19.7 87.3892332401073 -0.0903382917084904 0.389350802855205 -0.232022872550968 0.816520248778694 0.903503505521441 Hypothetical protein VI - Unknowns Rv2827c - 129.2 62 65.3 42.9 12.7 95.2807354930536 -0.886221800897032 0.386004219168577 -2.29588630612868 0.0216823829263082 0.0740588238427999 Hypothetical protein VI - Unknowns Rv2828c - 68.4 24.6 42.4 24.4 5.1 30.4422092429744 -0.941813613524151 0.618781469244457 -1.522045601453 0.127997654920193 0.278139689403266 hypothetical protein V - Conserved hypotheticals Rv2828A - 86.1 26.1 44.4 43.5 4.5 17.803029123333 -0.374751135541881 0.769416314383592 -0.487058993338487 0.62621652517967 0.782596643106496 hypothetical protein ? Rv2829c vapC22 130.8 44.9 68.6 90.8 35.7 55.8181488964062 0.390735065515736 0.464119317402413 0.841884943946322 0.399852358661249 0.599442325641651 Possible toxin VapC22 V - Conserved hypotheticals Rv2830c vapB22 322 137 126.6 251.9 77.2 74.5757243356936 0.547945939830771 0.405885330492857 1.35000183220569 0.17701539516504 0.347554617336237 Possible antitoxin VapB22 IV.B.3 - Phage-related functions Rv2831 echA16 72.2 20.7 29.6 20.2 0 32.2570849268405 -1.30637547015106 0.69257375651452 -1.88626187155226 0.059259674602291 0.158886628601408 Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv2832c ugpC 12.2 10.8 3.3 1.5 0 8.9050603031934 -2.64991689760473 1.17131711556679 -2.26233943172807 0.0236764399490366 0.0791897547681659 Probable Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter UgpC III.A.3 - Carbohydrates, organic acids and alcohols Rv2833c ugpB 11.2 7.9 7 1.2 0 11.4168617627498 -2.9983899820096 1.05676783212769 -2.83732139723884 0.00454937915188416 0.0211746398895844 Probable Sn-glycerol-3-phosphate-binding lipoprotein UgpB III.A.3 - Carbohydrates, organic acids and alcohols Rv2834c ugpE 11.7 5.1 8.9 3.6 0 7.76016851929396 -1.48581290711138 1.15673769122597 -1.28448559978766 0.198972098969924 0.376411819168786 Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpE III.A.3 - Carbohydrates, organic acids and alcohols Rv2835c ugpA 10.9 12.7 4.1 1.2 0 8.01830315851136 -2.98728962878311 1.24399370101214 -2.40137038182154 0.0163337945770991 0.0593986657002926 Probable Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter UgpA III.A.3 - Carbohydrates, organic acids and alcohols Rv2836c dinF 45.8 35 26.9 4.6 1.5 48.6374261505516 -2.951886879065 0.567400370288397 -5.20247612380764 1.96650630603547e-07 3.74482007310625e-06 Possible DNA-damage-inducible protein F DinF II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2837c - 163.2 130 88.6 72.5 19.6 169.246292546303 -0.768427839460205 0.332777988446922 -2.30913061000959 0.0209363346366796 0.0721366705088708 hypothetical protein V - Conserved hypotheticals Rv2838c rbfA 454 292.5 271.2 218.7 76.9 266.396840987429 -0.458954672404342 0.290314923551268 -1.58088556657782 0.113904205068284 0.256157901175786 Probable ribosome-binding factor a RbfA (P15B protein) II.A.2 - Ribosome modification and maturation Rv2839c infB 334.7 185.6 168.4 193.9 62.7 947.101835966437 -0.0713195210868055 0.235216860207852 -0.30320752102457 0.76173171770081 0.875802258232129 Probable translation initiation factor if-2 InfB II.A.6 - Protein translation and modification Rv2840c - 1647.4 1195.8 1492.5 1216.5 821.8 831.956004435101 0.427755295332442 0.348034058531681 1.2290615956872 0.219048712728061 0.402422479503523 hypothetical protein V - Conserved hypotheticals Rv2841c nusA 135.9 70.9 59.1 131.7 27.9 163.455173595959 0.545961961242407 0.330675251538268 1.65105177573056 0.0987280031299256 0.231279488813622 Probable N utilization substance protein A NusA II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv2842c - 187.2 135.6 111.1 187.7 44.7 138.491602112226 0.351950917687891 0.34146880057378 1.03069714450192 0.302682864250555 0.499349187319732 hypothetical protein V - Conserved hypotheticals Rv2843 - 45.7 17.4 12.7 36.7 7 22.3972578390015 0.551259849455825 0.666456653928831 0.827150342345735 0.408151853340473 0.604865709307802 Probable conserved transmembrane alanine rich protein VI - Unknowns Rv2844 - 55.5 24.2 24 24.2 10.3 24.3898301670268 -0.22433058920019 0.628795236603367 -0.356762545486162 0.721269577873249 0.849224787904526 Conserved alanine rich protein VI - Unknowns Rv2845c proS 92.4 55.8 40.7 117.7 36.1 241.907118566262 1.05584207825137 0.283805256324171 3.7203048735833 0.000198982428452978 0.00160180854904647 Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2846c efpA 1072.8 715.6 552 1886 735.1 3499.95765776226 1.5719838978354 0.226726256275344 6.93340032010378 4.10843437332986e-12 2.02112146532422e-10 Possible integral membrane efflux protein EfpA III.A.6 - Efflux proteins Rv2847c cysG 77.5 29.7 33.6 45.8 14.3 89.1063192751118 0.121038621724935 0.391754165475343 0.308965755547411 0.757347576306642 0.873502154112057 Possible multifunctional enzyme siroheme synthase CysG: uroporphyrin-III C-methyltransferase (urogen III methylase) (SUMT) (uroporphyrinogen III methylase) (UROM) + precorrin-2 oxidase + ferrochelatase I.D.3 - Serine family Rv2848c cobB 79.9 38.8 47.4 16.2 6.2 88.4991032734 -1.57692545781304 0.419083786101818 -3.76279281162627 0.000168026399807993 0.00139706457305144 Probable cobyrinic acid A,C-diamide synthase CobB I.G.13 - Cobalamin Rv2849c cobO 161.4 87.5 93 63.2 21.2 94.9921030824653 -0.685657022720346 0.382717100396586 -1.79155052651121 0.0732049941047263 0.18428719908951 Probable cob(I)alamin adenosyltransferase CobO (corrinoid adenosyltransferase) (corrinoid adotransferase activity) I.G.13 - Cobalamin Rv2850c - 135.3 52.1 84.2 60.2 11 223.326172798475 -0.724739265547442 0.371071924379014 -1.95309646980242 0.0508081652086296 0.141591283374482 Possible magnesium chelatase IV.K - Chelatases Rv2851c - 257 165.5 145 180 47.7 138.710955323282 -0.0151992567407436 0.333498494853437 -0.0455751884200355 0.963648845389919 0.984610856411041 GCN5-related N-acetyltransferase V - Conserved hypotheticals Rv2852c mqo 140.9 103.1 60 93.6 18.4 217.809725675222 -0.175786577981666 0.327356382152861 -0.536988394194745 0.591275630800381 0.757979835068748 Probable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor]) V - Conserved hypotheticals Rv2853 PE_PGRS48 17.3 4.8 12.8 12.7 3.2 34.8155339379999 0.146580756585322 0.594130707676694 0.246714661759389 0.805129058818227 0.897686131592986 PE-PGRS family protein PE_PGRS48 IV.C.1.b - PE_PGRS subfamily Rv2854 - 16.8 27.6 9.1 23.9 13.3 40.7242293019377 0.915635794771635 0.577067071038717 1.58670601863228 0.112579242575703 0.254254649858247 hypothetical protein VI - Unknowns Rv2855 mtr 108.9 63.2 55 103.9 43.9 213.681906647541 0.793211283772877 0.299864312815896 2.6452340270977 0.0081634435789616 0.034218836871813 NADPH-dependent mycothiol reductase Mtr I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv2856 nicT 95.2 73.5 63.8 29.4 5.3 102.020859361556 -1.46793125820978 0.409867980003517 -3.58147337637155 0.000341661959671413 0.00253703702548458 Possible nickel-transport integral membrane protein NicT III.A.2 - Cations Rv2857c - 74.1 61.7 40.3 26.2 12.5 60.840545711228 -0.837245292924078 0.459136025019 -1.82352341637629 0.0682241538158254 0.174728816207992 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2858c aldC 82.8 44.4 37.1 23.9 6.2 88.913388250943 -1.09790306678056 0.394585647313965 -2.78242017735373 0.00539551360046109 0.0245326176801453 Probable aldehyde dehydrogenase AldC I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2859c - 51.4 41.9 25.6 10.5 5.6 42.9453080790873 -1.60285606341864 0.54273279618885 -2.95330607376987 0.00314390073655597 0.0157729410890669 Possible amidotransferase V - Conserved hypotheticals Rv2860c glnA4 48.6 34.7 26.4 20.7 7.5 67.9362750453 -0.65195958587794 0.422745112587752 -1.54220490424383 0.123023808709879 0.269906518364127 Probable glutamine synthetase GlnA4 (glutamine synthase) (GS-II) I.D.1 - Glutamate family Rv2861c mapB 393.7 287.6 213.9 114.6 69.2 342.609920375233 -0.802993970202736 0.321037119247843 -2.50124961276774 0.0123755918430471 0.0475942956656599 Methionine aminopeptidase MapB (map) (peptidase M) II.B.3 - Proteins, peptides and glycopeptides Rv2862c - 26.9 10.1 12.3 20.5 0.1 12.6032164720109 -0.0153910601366585 0.91487596043054 -0.0168231113313061 0.986577732328892 0.996139774204371 hypothetical protein V - Conserved hypotheticals Rv2862A vapB23 0.8 0 0 0 0 0.0246867392782753 0.796308846248315 4.46498467717724 0.178345258454894 0.858451837397389 NA Possible antitoxin VapB23 ? Rv2863 vapC23 0.1 0 0 0.5 0 0 NA NA NA NA NA Possible toxin VapC23 V - Conserved hypotheticals Rv2864c - 17.2 10.3 3.7 8.4 5.4 31.9358182151981 0.33552009306273 0.609697757588586 0.550305604517466 0.582109780812223 0.75194487368231 Possible penicillin-binding lipoprotein II.C.3 - Murein sacculus and peptidoglycan Rv2865 relF 94.4 69.3 52.5 61.1 5.9 26.3505294499147 -0.458587509059918 0.651487092837805 -0.70390881738326 0.481489560017683 0.669542764321112 Antitoxin RelF V - Conserved hypotheticals Rv2866 relG 25.9 23.4 26.7 14.1 44.5 19.7785884975631 1.22721054744919 0.864452949716804 1.41963833641984 0.155712998580862 0.31973069041937 Toxin RelG V - Conserved hypotheticals Rv2867c - 325.4 165.6 107.5 249.2 42 264.68557782138 0.220030683750656 0.336021771332381 0.654810796568919 0.51258957848769 0.697232061061213 GCN5-related N-acetyltransferase VI - Unknowns Rv2868c gcpE 357.8 227.2 229 243.9 92.8 520.868084348426 0.0829064820029659 0.268100111797327 0.309237028836601 0.757141228408721 0.873502154112057 Probable GcpE protein V - Conserved hypotheticals Rv2869c rip 142.8 90.4 67.7 131.2 35.7 215.679773623454 0.461165964722798 0.294637998960445 1.56519514234384 0.117537160183297 0.262660328939583 Membrane bound metalloprotease II.C.5 - Other membrane proteins Rv2870c dxr 82.3 42 35.6 58 19.5 111.226782514181 0.325083225104867 0.350205460745565 0.928264294944989 0.353270490304007 0.553665520644598 Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase) V - Conserved hypotheticals Rv2871 vapB43 45.9 25.9 8.8 127.4 0 17.0968169929961 1.80850533892023 0.885501623833461 2.04235123939237 0.0411167028289503 0.120959602508423 Possible antitoxin VapB43 V - Conserved hypotheticals Rv2872 vapC43 17.4 4.8 2.4 24.7 13.1 11.6178330088927 2.03528402061981 0.935382026018695 2.17588532172537 0.0295638366303376 0.0938307431403724 Possible toxin VapC43 Contains PIN domain V - Conserved hypotheticals Rv2873 mpt83 17 3.9 7.2 33 18.3 25.7075984847102 2.33709863165385 0.659654491530649 3.54291323967323 0.00039573287255139 0.00286058333587148 Cell surface lipoprotein Mpt83 (lipoprotein P23) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2874 dipZ 6.9 8.2 2.9 7.8 1.9 21.200268536454 0.432146392029237 0.685858753839781 0.630080741274883 0.528641759307705 0.708455963476312 Possible integral membrane C-type cytochrome biogenesis protein DipZ II.C.5 - Other membrane proteins Rv2875 mpt70 23.3 20.2 25 16.2 6.3 20.4811854879003 -0.335149205409318 0.708313893820823 -0.473164804944653 0.636095605194418 0.789712805327244 Major secreted immunogenic protein Mpt70 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2876 - 100.6 70.9 46 75 9.6 31.7845399872354 -0.115284980101079 0.59109972139277 -0.195034739365873 0.845365751720206 0.915606208783323 Possible conserved transmembrane protein VI - Unknowns Rv2877c - 39.8 13.7 15.4 25.1 3.9 27.3527004844315 0.00347295702188831 0.63529487036646 0.00546668513140204 0.995638238059847 0.999305933467831 Probable conserved integral membrane protein III.A.2 - Cations Rv2878c mpt53 218.4 189.8 132.2 161.3 72.8 161.604119851611 0.182169787200783 0.341394334577742 0.533605185411474 0.593614719909136 0.759055356649155 Soluble secreted antigen Mpt53 precursor II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2879c - 565.9 282.5 291.2 537.4 178.1 418.434553279235 0.68331808923095 0.264713308877235 2.58135147087693 0.00984143298259658 0.0390351126812509 hypothetical protein V - Conserved hypotheticals Rv2880c - 197.8 111.7 104.7 153.2 45.4 191.388798519733 0.256769113866073 0.303000861477219 0.847420408688766 0.396760832919407 0.596237910997226 hypothetical protein V - Conserved hypotheticals Rv2881c cdsA 151 85.5 62 188.6 23.2 167.58241147695 0.6815795992567 0.377798074430078 1.80408436513311 0.0712180823517135 0.180439519091394 Probable integral membrane phosphatidate cytidylyltransferase CdsA (CDP-diglyceride synthetase) (CDP-diglyceride pyrophosphorylase) (CDP-diacylglycerol synthase) (CDS) (CTP:phosphatidate cytidylyltransferase) (CDP-DAG synthase) (CDP-DG synthetase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2882c frr 300.5 251.9 198 398.3 268.3 376.194342334458 1.37945357557384 0.338638715751662 4.07352588882794 4.63067013972789e-05 0.000472675320890956 Ribosome recycling factor Frr (ribosome releasing factor) (RRF) II.A.6 - Protein translation and modification Rv2883c pyrH 290.1 149.1 118.1 210.5 60.2 242.221000238717 0.314259336073262 0.290446181066753 1.08198818424483 0.279257778254903 0.475772511100946 Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase) I.F.2 - Pyrimidine ribonucleotide biosynthesis Rv2884 - 48.6 11.3 38.4 60.1 11.9 48.8000182800689 0.721052154005673 0.561178562711245 1.28488898528487 0.198831080537893 0.376408170638811 Probable transcriptional regulatory protein I.J.2 - Two component systems Rv2885c - 60.4 40.9 27.3 55.2 9.9 95.7281912018806 0.278430482948151 0.391996634652441 0.710287942127407 0.477525595597305 0.666166073101873 Probable transposase IV.B.1.c - Others Rv2886c - 20.3 11.4 17.8 10.3 2.3 18.6011606632886 -0.810249930505476 0.756980912996399 -1.07037035755396 0.284452636448276 0.480916121351566 Probable resolvase IV.B.1.c - Others Rv2887 - 44.3 26.6 12.4 31.5 8.5 18.5317278577762 0.362807240160744 0.702741674074013 0.516273978825586 0.605663067530672 0.76692285009813 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv2888c amiC 166.5 85.2 93 127 29.4 261.979845587479 0.121609708432689 0.30289682777968 0.401488880963604 0.688060222864358 0.827260458039904 Probable amidase AmiC (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv2889c tsf 210.3 109.9 101.9 330.7 73.4 265.057142865137 1.19779655925596 0.296765476756093 4.03617217322219 5.43303519823321e-05 0.000537536610953688 Probable elongation factor Tsf (EF-ts) II.A.6 - Protein translation and modification Rv2890c rpsB 276.9 154.6 224.6 422.6 246.3 545.140731543897 1.51142676995806 0.336978302558566 4.48523468271484 7.28337249006068e-06 9.84645242740264e-05 30S ribosomal protein S2 RpsB II.A.1 - Ribosomal protein synthesis and modification Rv2891 - 1.1 2.3 0.3 0.4 0 0.632307244899289 -0.286712111542847 3.23954309979013 -0.0885038731423026 0.92947620609876 NA hypothetical protein VI - Unknowns Rv2892c PPE45 17 4.8 8.1 12.9 4.8 22.5834565211272 0.646639575156603 0.661326518631784 0.977791691303161 0.328177361234227 0.528605826962998 PPE family protein PPE45 IV.C.2 - PPE family Rv2893 - 3.2 1.8 1 2.7 0 2.18256746187042 0.349361973458671 1.89471193180499 0.184387910158909 0.853709153509702 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2894c xerC 79.6 27 29.9 55.1 10.9 63.3500496211359 0.276377327490334 0.458600149760983 0.602654246045011 0.546738725203409 0.724485059734558 Probable integrase/recombinase XerC IV.B.3 - Phage-related functions Rv2895c viuB 78.4 62.2 36.9 58.7 15.1 77.6065080104165 0.0296595132084076 0.40772864097902 0.0727432665441174 0.942010418005644 0.973691654363404 Possible mycobactin utilization protein ViuB I.G.14 - Iron utilisation Rv2896c - 35.5 24.6 10.1 15.4 6.1 38.205851992236 -0.276684867646084 0.54429916060864 -0.508332343075254 0.611220291584762 0.770037761217479 hypothetical protein V - Conserved hypotheticals Rv2897c - 6.7 4.3 3.6 1.2 1.3 8.60910831904871 -1.6162264516845 1.08265086786233 -1.49284178275837 0.135478607209125 0.288950918523647 hypothetical protein V - Conserved hypotheticals Rv2898c - 28.3 23.1 17.6 22.6 7.6 13.7896852599941 0.0983650573518888 0.79248585313832 0.124122161881318 0.901218551201781 0.95116689760331 hypothetical protein V - Conserved hypotheticals Rv2899c fdhD 57.2 31.9 32.1 34.7 10.3 50.4102418561978 -0.107782921900295 0.463012966260176 -0.232785968762113 0.815927608953988 0.903402026238493 Possible FdhD protein homolog I.B.6.b - anaerobic Rv2900c fdhF 149.9 91.1 73.4 92.5 27.4 374.475070119609 -0.0595304924552603 0.263109851692496 -0.226257177647743 0.821001402068872 0.905069083762199 Possible formate dehydrogenase H FdhF (formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide) (formate dehydrogenase-H alpha subunit) (FDH-H) I.B.6.b - anaerobic Rv2901c - 1023 812.2 542.8 481.7 160.3 335.795247655823 -0.560688814350222 0.284297158016045 -1.97219282198585 0.0485875987845749 0.137129302705151 hypothetical protein VI - Unknowns Rv2902c rnhB 629.6 355.9 285.9 213.6 62.8 424.98883777497 -0.857362009680137 0.263738983752539 -3.25079742661245 0.00115081824097768 0.0069917636527323 Probable ribonuclease HII protein RnhB (RNase HII) II.B.1 - RNA Rv2903c lepB 565.5 306.2 277.2 415.5 127 566.156667125808 0.260655985115184 0.248195343901131 1.05020497571871 0.293623882379149 0.489419195946797 Probable signal peptidase I LepB (SPASE I) (leader peptidase I) III.D - Protein and peptide secretion Rv2904c rplS 790.5 405.9 396.1 894 323.8 395.617564020565 0.997099664733272 0.264615439369508 3.76810841842424 0.000164489263500915 0.00137087287369468 50S ribosomal protein L19 RplS II.A.1 - Ribosomal protein synthesis and modification Rv2905 lppW 304 162.3 120.5 172.8 48 274.218671441743 -0.0625647738325435 0.286786795549387 -0.218157791095962 0.827306170811852 0.907781430302224 Probable conserved alanine rich lipoprotein LppW II.C.1 - Lipoproteins(lppA-lpr0) Rv2906c trmD 15 6.2 6.1 12.4 5.6 12.3113356112511 0.794523327119912 0.834041269305476 0.952618720871605 0.34078328840318 0.542496362932164 Probable tRNA (guanine-N1)-methyltransferase TrmD (M1G-methyltransferase) (tRNA [GM37] methyltransferase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2907c rimM 28.5 25.5 7.8 46.1 7.4 22.2672470476384 1.08867779866124 0.68410695324689 1.59138537255643 0.111522874186983 0.252243946596611 Probable 16S rRNA processing protein RimM II.A.2 - Ribosome modification and maturation Rv2908c - 81.6 45.4 31.2 72.1 24 22.3863149575508 0.612590266441836 0.636168229773355 0.962937534086041 0.335578872045378 0.5370935111668 hypothetical protein V - Conserved hypotheticals Rv2909c rpsP 161.5 89 73.6 110.1 42 89.5716886995599 0.282650867311557 0.374163411075664 0.755420917558395 0.449996466319893 0.64349198451521 30S ribosomal protein S16 RpsP II.A.1 - Ribosomal protein synthesis and modification Rv2910c - 44.6 27 9.9 97.6 8.7 29.0839638505428 1.63809032665474 0.656490824669921 2.49522196670206 0.0125878360208845 0.0482012056064573 hypothetical protein V - Conserved hypotheticals Rv2911 dacB2 27 21.6 14.8 8.4 2.3 21.4286268479844 -1.34310345014637 0.703347979804419 -1.90958599258343 0.0561865400604032 0.153086711456883 Probable penicillin-binding protein DacB2 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase) II.C.3 - Murein sacculus and peptidoglycan Rv2912c - 22.3 9.9 12.7 15.7 2.5 12.3027231757735 -0.0212921356695287 0.856167828355113 -0.0248691144006609 0.980159362749198 0.993121291743379 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv2913c - 20.4 10.2 10.1 11.6 5.6 40.5229689535727 0.106161040299272 0.507269393165996 0.209279411944596 0.834230122812692 0.912551913218825 Possible D-amino acid aminohydrolase (D-amino acid hydrolase) I.A.2 - Amino acids and amines Rv2914c pknI 31.7 29.4 19.3 9.4 10.1 70.3984764997675 -0.517602433444797 0.515885184221616 -1.00332874305311 0.315702272285315 0.513414806443795 Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv2915c - 30.4 15.3 19.4 26.4 9 43.3525193778173 0.436831552859485 0.492736254032381 0.886542342449148 0.375325347810756 0.576497130071855 hypothetical protein V - Conserved hypotheticals Rv2916c ffh 58.5 19.9 24.9 54.6 15.7 104.562383763032 0.779475695992522 0.382394744861577 2.03840587891626 0.041509358852756 0.121912229731726 Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein) III.D - Protein and peptide secretion Rv2917 - 1.4 0 0.6 0.4 0 1.11179531796979 -0.340853617688297 2.58604942207215 -0.131804757781921 0.895138723222002 NA Conserved hypothetical alanine and arginine rich protein V - Conserved hypotheticals Rv2918c glnD 86.7 55.7 43.7 24.4 2.6 168.25306289659 -1.55580671508371 0.390999189905023 -3.97905355113812 6.91901565049694e-05 0.000657028242200005 Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl-transferase) (uridylyl removing enzyme) (UTASE) I.D.1 - Glutamate family Rv2919c glnB 918.7 761.8 675.8 515.7 342.3 450.245842504954 0.0558055260132179 0.337532512028102 0.165333779782884 0.868681272247194 0.931537713078886 Probable nitrogen regulatory protein P-II GlnB I.J.1 - Repressors/activators Rv2920c amt 117.7 119 84.3 69.9 41 249.757206128356 -0.0973509638141 0.353031539034034 -0.275757129463481 0.782734613133452 0.885336132396263 Probable ammonium-transport integral membrane protein Amt III.A.2 - Cations Rv2921c ftsY 113.5 61.9 48.1 60.6 19.2 138.754334756163 -0.122946371323128 0.331036606771037 -0.371398113708206 0.710341030311701 0.842608147811134 Probable cell division protein FtsY (SRP receptor) (signal recognition particle receptor) III.C - Cell division Rv2922c smc 57.5 25.5 30.3 44.3 20.2 261.799027640637 0.624526274424905 0.310100863925247 2.01394561279085 0.0440152439202397 0.127683860741596 Probable chromosome partition protein Smc III.C - Cell division Rv2922A acyP 63 36.1 24.4 65.6 10.7 19.061802946077 0.597240781126422 0.702168591132011 0.850566072976251 0.395010442501882 0.594614104267602 Probable acylphosphatase AcyP (acylphosphate phosphohydrolase) ? Rv2923c - 45.9 8.3 33.7 44 14.1 22.7285933825174 0.626724694330371 0.703638122233707 0.890691783925559 0.373094543729277 0.574727979691124 hypothetical protein V - Conserved hypotheticals Rv2924c fpg 38.8 11.6 11.9 16.7 5.6 25.4376564794396 -0.0635610954156666 0.640001089045465 -0.0993140425908733 0.920888929163795 0.961895779150151 Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2925c rnc 479.5 297.8 221.5 482 168.9 478.834735587962 0.762494299958956 0.252089523090779 3.02469650705942 0.00248882733344059 0.0132762446009738 Probable ribonuclease III Rnc (RNase III) II.B.1 - RNA Rv2926c - 461.3 247.1 154.6 506.9 102.8 341.098349849129 0.77973533422085 0.306583739603139 2.54330296587219 0.0109809969663111 0.0429775593974298 hypothetical protein VI - Unknowns Rv2927c - 637 373 275.7 694.2 214.8 643.667572853889 0.857534075848382 0.24287300722586 3.53079202025492 0.000414317387560311 0.00295869392487625 hypothetical protein V - Conserved hypotheticals Rv2928 tesA 92.5 65.6 37.8 58.6 22.2 81.3445718854597 0.0946848068497266 0.39429422108847 0.240137445048888 0.810223706392898 0.900180115344522 Probable thioesterase TesA I.I - Polyketide and non-ribosomal peptide synthesis Rv2929 - 95.4 32.4 37.8 129.3 49.3 45.7494531291528 1.52711002488214 0.496092768094667 3.0782751192832 0.00208202603244081 0.0113629217363719 Hypothetical protein VI - Unknowns Rv2930 fadD26 596.3 386.4 314.4 291 96.5 1077.37855495008 -0.401628370771915 0.233145309409688 -1.72265258858871 0.0849513688907759 0.207505505856918 Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2931 ppsA 165 105 78.3 15.4 6 677.161080562266 -2.66110040356205 0.268384655635375 -9.9152479386802 3.57368056367881e-23 9.0414118261074e-21 Phenolpthiocerol synthesis type-I polyketide synthase PpsA I.I - Polyketide and non-ribosomal peptide synthesis Rv2932 ppsB 95.9 74.9 54.4 3.9 0.4 340.003757974676 -4.39220312426056 0.406888568029907 -10.7946093091948 3.65011632814629e-27 1.29287120342942e-24 Phenolpthiocerol synthesis type-I polyketide synthase PpsB I.I - Polyketide and non-ribosomal peptide synthesis Rv2933 ppsC 136.2 101.5 59.3 5.3 1.8 632.174752494834 -4.0362829751607 0.312732597987051 -12.9064990382865 4.13685904540695e-38 7.32637736941571e-35 Phenolpthiocerol synthesis type-I polyketide synthase PpsC I.I - Polyketide and non-ribosomal peptide synthesis Rv2934 ppsD 113 80.6 59.1 18.8 7 515.114437045232 -1.9444197813586 0.27310113086513 -7.11977931105252 1.08100010347394e-12 6.28241307954937e-11 Phenolpthiocerol synthesis type-I polyketide synthase PpsD I.I - Polyketide and non-ribosomal peptide synthesis Rv2935 ppsE 154.4 98.3 76.8 59.8 14.3 623.531124926418 -0.876625392125813 0.259761042804845 -3.37473773072435 0.000738860688525654 0.00481577553581552 Phenolpthiocerol synthesis type-I polyketide synthase PpsE I.I - Polyketide and non-ribosomal peptide synthesis Rv2936 drrA 267.7 207.1 154.9 72.4 30.6 258.005599260666 -1.27120698809303 0.310072737513914 -4.09970576028468 4.13675741711033e-05 0.000434789162356225 Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA III.A.6 - Efflux proteins Rv2937 drrB 169.5 99 92.7 37.8 10.3 119.231112376423 -1.60448030343418 0.371407617531096 -4.31999837294625 1.56030351177778e-05 0.000191895661066558 Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB III.A.6 - Efflux proteins Rv2938 drrC 213.3 112 65.5 41 13 119.108700035141 -1.44409348469807 0.386518646277126 -3.73615477185204 0.000186855684901442 0.00152147778372623 Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC III.A.6 - Efflux proteins Rv2939 papA5 134.3 108.4 72.2 16.8 10.3 148.544511408231 -2.19255934296254 0.395594303365967 -5.54244417653857 2.98278510941119e-08 6.76476629190982e-07 Possible conserved polyketide synthase associated protein PapA5 I.I - Polyketide and non-ribosomal peptide synthesis Rv2940c mas 287.1 187.3 146.1 153.7 34.2 1810.44407374924 -0.497680593178801 0.247591125461228 -2.01009059695372 0.0444216010902196 0.128441886580864 Probable multifunctional mycocerosic acid synthase membrane-associated Mas I.I - Polyketide and non-ribosomal peptide synthesis Rv2941 fadD28 1013.2 744.6 584.4 824.8 483.5 2726.82281739696 0.702356877157397 0.283117901771789 2.48079288791685 0.0131090517384017 0.0496601724678276 Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2942 mmpL7 448.4 272.2 271.3 160.2 65.4 1224.45065972014 -0.745551278131056 0.251768970089137 -2.96125165014218 0.00306391482531013 0.0155255884281094 Conserved transmembrane transport protein MmpL7 II.C.4 - Conserved membrane proteins Rv2943 - 17.7 9.4 12.8 7.8 1.6 20.3595099386527 -0.89701905530389 0.719956867636999 -1.24593443805604 0.212788465680243 0.393575323989253 Probable transposase for insertion sequence element IS1533 IV.B.1.c - Others Rv2943A - 7.1 14.7 5.9 6.3 0 5.69463902728429 -0.804320321428505 1.31430566156176 -0.611973565169575 0.540555247526603 NA Possible transposase ? Rv2944 - 12.8 23.4 12.8 7.3 1.2 13.757686372355 -1.48678115117952 0.956713018725881 -1.55405134254321 0.120172170247729 0.266697886602417 Possible transposase for insertion sequence element IS1533 IV.B.1.c - Others Rv2945c lppX 125.4 111.5 56.8 14.2 12.9 77.2937088918106 -2.16963455093298 0.509121560545906 -4.26152557476959 2.03036113368457e-05 0.000236563787352328 Probable conserved lipoprotein LppX II.C.1 - Lipoproteins(lppA-lpr0) Rv2946c pks1 78.8 68.9 36.8 5.7 2 302.668425168767 -3.26696029117616 0.352759961216429 -9.26114256252505 2.02256157418735e-20 3.25632413444163e-18 Probable polyketide synthase Pks1 I.I - Polyketide and non-ribosomal peptide synthesis Rv2947c pks15 66.9 73 52.7 2 1.4 98.1525026580572 -4.90179009696429 0.596631310941156 -8.21577749453337 2.1079399641595e-16 2.33322604782905e-14 Probable polyketide synthase Pks15 I.I - Polyketide and non-ribosomal peptide synthesis Rv2948c fadD22 215.3 252 117.5 40.1 7.1 447.021305288417 -2.44856461180735 0.370121943839489 -6.615561850797 3.70143181887952e-11 1.48982630709901e-09 P-hydroxybenzoyl-AMP ligase FadD22 I.A.3 - Fatty acids Rv2949c - 879.4 930.8 560 364.7 119 619.318853030403 -1.00669011050862 0.298542321633655 -3.37201809445274 0.000746195458142179 0.00484070386948644 Chorismate pyruvate lyase VI - Unknowns Rv2950c fadD29 909.5 747.7 566 627.7 315.4 2384.99804830463 0.224850140588774 0.271675550537918 0.827642164131332 0.407873182085159 0.604865709307802 Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv2951c - 170.4 115.8 77 52.1 10 161.707477338348 -1.26918896310093 0.354730152738239 -3.57789985797313 0.000346366098533264 0.00256658728243686 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2952 - 176.9 171.5 86.3 36.4 19.4 139.58369999332 -1.59630159914373 0.398872591652468 -4.00203381368095 6.28003208589958e-05 0.000606100099407529 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2953 - 83.4 60.3 32.9 25.9 11.3 95.1311889195876 -0.846063926380489 0.398405644697998 -2.12362434528715 0.0337015681411838 0.103351475632964 Enoyl reductase V - Conserved hypotheticals Rv2954c - 164.7 106.9 92.9 122.1 38.6 144.350693608599 0.135166237499111 0.325826362583691 0.414841317403812 0.678258070845721 0.820589432842296 Hypothetical protein VI - Unknowns Rv2955c - 50.7 37.1 30.9 9.2 10.5 49.9098340654273 -1.25115926841933 0.56616403962901 -2.209888267081 0.0271129177247103 0.0878627214830046 hypothetical protein V - Conserved hypotheticals Rv2956 - 200.1 132.9 122.8 389.2 131.1 310.794340448931 1.52580448572372 0.277288451963601 5.50258936107445 3.74253423076338e-08 8.23357530767943e-07 hypothetical protein V - Conserved hypotheticals Rv2957 - 119.3 61.9 60.7 70.9 52.4 128.968962829233 0.571844872160868 0.394303731354447 1.45026492698043 0.146984655570317 0.305847027028212 Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2958c - 18.1 12.8 11.8 5.9 6.6 28.9103880057069 -0.319914078626391 0.65743746929134 -0.486607614517667 0.626536426397027 0.782596643106496 Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2959c - 50 43.5 39.9 77.3 38.8 83.3886033504941 1.19871274953804 0.418607232402234 2.86357391070161 0.00418891073707969 0.0198889032583596 Possible methyltransferase (methylase) IV.H - Miscellaneous transferases Rv2960c - 74.7 67.7 39.4 78.4 34.7 30.0952965371995 0.690006879843471 0.572087452087906 1.20612133219353 0.227770710715271 0.4111946265818 Hypothetical protein VI - Unknowns Rv2961 - 1.4 1 2.6 3.9 0 0.899009830100642 1.51938332421137 2.82189145284581 0.538427274613667 0.590282100726919 NA Probable transposase V - Conserved hypotheticals Rv2962c - 16.2 8.4 6 15.5 4.4 25.9807371179761 0.750894841165401 0.596949941668655 1.25788577693202 0.208433068196767 0.389177610729018 Possible glycosyl transferase IV.H - Miscellaneous transferases Rv2963 - 20.2 21.7 4.2 8.6 0 20.6099413540545 -1.09742226497661 0.837857109342317 -1.3097964470792 0.190264705406263 0.365465068627432 Probable integral membrane protein II.C.5 - Other membrane proteins Rv2964 purU 14.9 7.7 8.5 8.8 4.2 15.3803677944645 0.094039931323983 0.762994555928581 0.123251117053561 0.901908248543631 0.951569220060685 Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) I.F.1 - Purine ribonucleotide biosynthesis Rv2965c kdtB 90.4 94.2 42.7 27.8 8.9 43.6973176216555 -1.35392254327917 0.546568135264568 -2.47713405872773 0.0132442145478665 0.0499584748972771 Probable phosphopantetheine adenylyltransferase KdtB (pantetheine-phosphate adenylyltransferase) (PPAT) (dephospho-CoA pyrophosphorylase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv2966c - 36.8 41 18.4 6.3 2.2 19.8147773043852 -2.21668217766915 0.789575849786121 -2.80743411575924 0.00499378938329531 0.0229714311631584 Possible methyltransferase (methylase) V - Conserved hypotheticals Rv2967c pca 52.7 35.8 29.7 25.3 6.4 180.22655809976 -0.61151551533167 0.320358027545414 -1.9088502948314 0.0562814066057605 0.153227319137282 Probable pyruvate carboxylase Pca (pyruvic carboxylase) I.B.3 - TCA cycle Rv2968c - 63.4 31 32.7 80.3 8.7 47.8069963641904 0.643571838011318 0.522230398349266 1.23235231048519 0.217817507090587 0.401180944237299 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv2969c - 181.8 116.3 69.4 201.5 68 196.658534750733 0.945591098747592 0.307166107170853 3.07843566289568 0.00208090456467332 0.0113629217363719 Possible conserved membrane or secreted protein II.C.5 - Other membrane proteins Rv2970c lipN 136.9 100 70.7 75.9 19.2 163.026268727234 -0.397473911058312 0.327682326620823 -1.21298550079647 0.225135364016242 0.408938184279759 Probable lipase/esterase LipN II.B.5 - Esterases and lipases Rv2970A - 132.4 101.8 83.6 160 66.1 38.2916678764622 0.861364038394737 0.512414376370793 1.68099116284637 0.0927646310863408 0.221409921366455 hypothetical protein ? Rv2971 - 127.3 84.2 77.3 67.1 56.4 149.927340995012 0.335360889190243 0.402182313634188 0.833852901585515 0.404363880429258 0.603055521886498 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2972c - 18.4 12.1 7.5 2.3 0 8.62134918093326 -2.60749360993519 1.14991943211574 -2.2675446097451 0.0233569769964725 0.0784174526270194 Possible conserved membrane or exported protein VI - Unknowns Rv2973c recG 18.5 10.1 10.2 6.9 0.9 33.0403580063521 -1.06465028430895 0.607321958260107 -1.75302451990873 0.0795977983210867 0.198127478322761 Probable ATP-dependent DNA helicase RecG II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2974c - 20.9 11.2 7.7 8.4 0 20.9474230409595 -0.940614317873954 0.761375707109091 -1.23541414454294 0.216676411273731 0.399427848950738 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2975c - 40.1 27.4 25.8 38.1 7 11.9427378604226 0.172169080942763 0.859538506916307 0.200304092902643 0.841242761741714 0.91350881138875 hypothetical protein V - Conserved hypotheticals Rv2976c ung 32.9 9.8 17.9 23.1 0 18.0170281478759 -0.215319629972125 0.824628890033042 -0.261110946481026 0.794006950360129 0.893667816388807 Probable uracil-DNA glycosylase Ung (UDG) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2977c thiL 53.2 29.6 29.9 14 13.7 54.2496618472838 -0.592189563688502 0.526409529556918 -1.12495980873855 0.260606065837983 0.454488766714985 Probable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase) I.G.8 - Thiamine Rv2978c - 94.4 60.8 38.1 49.1 4.4 111.664538996516 -0.647156375580195 0.432731391695271 -1.49551520411979 0.134780034917305 0.288105542351897 Probable transposase IV.B.1.c - Others Rv2979c - 106.8 63.5 53.4 47.6 13.5 57.7404390748272 -0.562369819618074 0.445414734170079 -1.26257569962501 0.206741705508401 0.387039704498286 Probable resolvase IV.B.1.c - Others Rv2980 - 32.5 12.6 11.1 27.5 9.9 19.0159527415975 0.786063075497508 0.692991049591601 1.13430480229255 0.256666715463389 0.448944941319172 Possible conserved secreted protein VI - Unknowns Rv2981c ddlA 88.6 72.5 54.3 37.9 21.1 118.314511435506 -0.459187566887 0.384298687297682 -1.19487154670218 0.232137221244788 0.416952351749006 Probable D-alanine--D-alanine ligase DdlA (D-alanylalanine synthetase) (D-ala-D-ala ligase) II.C.3 - Murein sacculus and peptidoglycan Rv2982c gpdA2 74.5 52.8 28.8 17.1 5.9 60.5632125112578 -1.39113623102864 0.465529134460594 -2.98829037336308 0.0028054287676224 0.014548797503541 Probable glycerol-3-phosphate dehydrogenase [NAD(P)+] GpdA2 (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv2983 - 35 24.6 27.3 9.6 7.9 25.5236376553009 -1.05480087796791 0.679862067015833 -1.551492470521 0.120783710366139 0.267384938823039 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv2984 ppk1 73.7 51.8 39.1 52.9 28.4 225.361618007554 0.447479222938618 0.320174778135076 1.39760922314073 0.162230447181847 0.328359696476486 Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase) I.A.4 - Phosphorous compounds Rv2985 mutT1 55.4 38.1 40 26 12.1 61.6838738819507 -0.519360111385845 0.453507151287942 -1.14520820655393 0.252122919663533 0.444288249476734 Possible hydrolase MutT1 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv2986c hupB 939.9 495.6 392.2 881.3 330.8 789.847431291964 0.837168707728078 0.244299164123889 3.42681773280048 0.000610698835658376 0.00410454511556351 DNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein) II.A.4 - Nucleoproteins Rv2987c leuD 453.9 219.6 254.8 169.6 63.4 249.984244302941 -0.625180340627816 0.307705120906578 -2.03175149892168 0.0421788194913625 0.123163543807425 Probable 3-isopropylmalate dehydratase (small subunit) LeuD (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) I.D.7 - Branched amino acid family Rv2988c leuC 685.1 306.1 307.9 221.9 70.9 782.50692390442 -0.771997046613222 0.25626374157004 -3.01250985365101 0.00259097024362136 0.0137306330847108 Probable 3-isopropylmalate dehydratase (large subunit) LeuC (isopropylmalate isomerase) (alpha-IPM isomerase) (IPMI) I.D.7 - Branched amino acid family Rv2989 - 816.6 274.3 316.4 189.5 52.3 378.703703152922 -1.15935969112027 0.317242576457553 -3.65448958354237 0.000257694124727158 0.00203285654740221 Probable transcriptional regulatory protein I.J.1 - Repressors/activators Rv2990c - 123.2 95.6 57.6 720.3 405.4 672.304296880941 3.58572004461759 0.303527003408078 11.8135124860596 3.32379634387024e-32 1.96214777499806e-29 Hypothetical protein VI - Unknowns Rv2991 - 95.9 51.9 37 40.7 8 37.9769531268917 -0.593721101304271 0.537600869978622 -1.10439014231484 0.269423935082921 0.464831747717343 hypothetical protein V - Conserved hypotheticals Rv2992c gltS 111.3 94.7 44.2 23.4 7.4 138.080252497059 -1.67683671432078 0.384940167139191 -4.35609701835675 1.32402109168616e-05 0.000165129672772972 Glutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS) II.A.3 - Aminoacyl tRNA synthases and their modification Rv2993c - 151.8 166.9 76.8 35.2 9.4 106.637468537119 -1.88134588530059 0.43872607486775 -4.28820166630785 1.80125520484563e-05 0.000212668197852107 Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase) V - Conserved hypotheticals Rv2994 - 36.8 20.2 13.9 16.2 3.8 41.0597707786688 -0.4795762736878 0.514676799409054 -0.931800839358689 0.351439460789179 0.552178724927541 Probable conserved integral membrane protein III.A.6 - Efflux proteins Rv2995c leuB 120.9 59.5 57.6 80.2 8.6 111.205135844058 -0.232534275792701 0.419721960680169 -0.554019797810612 0.579565296683445 0.749204482063052 Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) I.D.7 - Branched amino acid family Rv2996c serA1 61.6 24.3 30.4 47.4 16.2 109.817957179812 0.478859199288273 0.367610139584973 1.30262783237943 0.192701850987048 0.368348600213775 Probable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH) I.D.3 - Serine family Rv2997 - 10.4 6.1 3.7 6.3 2.4 14.249087328043 0.0606875246971268 0.783334294541259 0.077473340718048 0.938246998542838 0.973096145501906 Possible alanine rich dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv2998 - 8.6 0 8.9 10.1 0 4.18877187568415 0.316958972877208 1.54046380690154 0.205755546775704 0.836981866686539 NA Hypothetical protein VI - Unknowns Rv2998A - 1.6 0 0 2 0 0.134794331362578 1.39059033623594 4.43074404925885 0.31385029710045 0.753634741426698 NA hypothetical protein ? Rv2999 lppY 11.6 11.3 4.5 4.5 3.6 11.8986907977273 -0.567309570318436 0.897876518462244 -0.631834733009884 0.5274948750561 0.707990468908187 Probable conserved lipoprotein LppY II.C.1 - Lipoproteins(lppA-lpr0) Rv3000 - 6.5 1.3 4.9 2.6 0 2.86462325088924 -0.981739659426814 1.82211483233298 -0.538791322042982 0.59003085214512 NA Possible conserved transmembrane protein V - Conserved hypotheticals Rv3001c ilvC 193.8 106.5 75.3 62 30.7 169.26348676897 -0.558889761659672 0.339457338191407 -1.64642121050432 0.0996770691738931 0.232487594610968 Probable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase) I.D.7 - Branched amino acid family Rv3002c ilvN 278.2 159.2 146.7 115.3 33.5 131.031113607273 -0.654058145955155 0.342112010153925 -1.91182456781005 0.0558986994905687 0.152654736773781 Probable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS) I.D.7 - Branched amino acid family Rv3003c ilvB1 214.4 110.1 117.2 72.8 13.4 330.928340898158 -1.1161937907824 0.314075290955646 -3.55390513970749 0.000379556090127265 0.002766229776195 Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) I.D.7 - Branched amino acid family Rv3004 cfp6 122.3 88 77.7 38.2 5.8 37.003036101288 -1.46315278328107 0.590177889755331 -2.47917248117792 0.0131687608494798 0.0497798835953653 Low molecular weight protein antigen 6 (CFP-6) VI - Unknowns Rv3005c - 231.1 126.5 81.5 174.8 80.1 234.050465530102 0.69693207270707 0.311622466485044 2.23646286023 0.0253214675039585 0.0832866967216318 hypothetical protein V - Conserved hypotheticals Rv3006 lppZ 322.6 218.2 139.5 94.6 38.1 319.711639141206 -0.954685084809651 0.290393293547837 -3.28755899678649 0.00101060011642457 0.00622529671717533 Probable conserved lipoprotein LppZ II.C.1 - Lipoproteins(lppA-lpr0) Rv3007c - 20.8 17.7 2.3 32.8 5.5 16.6457095554094 1.18871958346074 0.818847578988649 1.45169823293477 0.146585530877858 0.305628951189143 Possible oxidoreductase VI - Unknowns Rv3008 - 89.3 53.4 39.6 61.9 24.4 63.8216221522141 0.273528662939216 0.419633269152933 0.651827876973047 0.514512215923691 0.698773876074277 Hypothetical protein VI - Unknowns Rv3009c gatB 139.6 71.6 77.7 103.3 49.6 276.081168594412 0.533194240157626 0.305708633993136 1.74412555246836 0.0811371992905328 0.200736924332046 Probable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3010c pfkA 140 61.6 56.2 99.9 23.8 141.605052898881 0.25667511229841 0.344810994338613 0.744393643221099 0.456638363579421 0.650871212827001 Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) I.B.1 - Glycolysis Rv3011c gatA 23.5 9.7 7.1 9.4 4 28.2776642367486 -0.12818969005686 0.604521625720023 -0.212051454576465 0.832066892024061 0.911593235864283 Probable glutamyl-tRNA(GLN) amidotransferase (subunit A) GatA (Glu-ADT subunit A) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3012c gatC 11.8 12.7 1.7 7 0 2.54620665223248 -0.302886321190844 1.90393003601513 -0.159084795901837 0.873602066780916 NA Probable glutamyl-tRNA(GLN) amidotransferase (subunit C) GatC (Glu-ADT subunit C) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3013 - 18.1 5.2 6.8 13.1 1.3 8.38112818221758 0.115705075738755 1.07727758309012 0.107405071408671 0.914467631379759 0.95801370906451 hypothetical protein V - Conserved hypotheticals Rv3014c ligA 25.7 8.1 10.3 9.8 7.6 50.8504532054774 0.181541607014114 0.527551842439785 0.344120885209182 0.730755376886528 0.855082770046938 DNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3015c - 15.7 9 7.3 5.3 0 11.4437778369624 -1.17282295331057 0.955507420483773 -1.22743468880312 0.219659255180258 0.40280903019061 hypothetical protein V - Conserved hypotheticals Rv3016 lpqA 43.1 27.1 29.2 38 49.9 61.7796550394163 1.50374873610931 0.547958032680545 2.74427720085268 0.00606443047178183 0.0270191355107563 Probable lipoprotein LpqA II.C.1 - Lipoproteins(lppA-lpr0) Rv3017c esxQ 7.7 2.7 0.7 3.8 0 1.01958600670874 0.530226385200079 2.88974119063435 0.183485769216476 0.854416883744947 NA ESAT-6 like protein EsxQ (TB12.9) (ESAT-6 like protein 8) V - Conserved hypotheticals Rv3018c PPE46 3.4 0 1.3 2.2 1.5 3.74555292657877 0.864343318334377 1.52754101585839 0.565839679171342 0.571502770175302 NA PPE family protein PPE46 IV.C.2 - PPE family Rv3018A PE27A 1.2 10.8 6.7 0 0 0 NA NA NA NA NA PE family protein PE27A ? Rv3019c esxR 3.8 2.5 0 0.1 0 0.222180653504478 -0.451834289233534 4.45530996974715 -0.10141478197962 0.919221202649329 NA Secreted ESAT-6 like protein EsxR (TB10.3) (ESAT-6 like protein 9) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3020c esxS 4.2 2.7 0 3.7 0 0.588550804006861 1.2960274833571 3.59330880752 0.360678013713934 0.71834016244093 NA ESAT-6 like protein EsxS IV.C.1.a - PE subfamily Rv3022A PE29 0.6 0 0 1.4 3.6 1.40245953291955 3.3922017794808 2.54330741879672 1.33377575766507 0.182277358156966 NA PE family protein PE29 ? Rv3023c - 2.8 2.8 3.4 2 4.7 10.9052345989291 1.29286046103274 1.03433373405611 1.2499451757827 0.211319575206246 0.391676575290697 Probable transposase IV.B.1.b - IS1081 Rv3024c trmU 75.2 34.3 43.2 56.8 17.5 95.1780143816123 0.281756088766287 0.38124180518302 0.739048249525066 0.459877699445823 0.652503806127907 Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU V - Conserved hypotheticals Rv3025c iscS 101.3 64.1 52.9 87.5 21.9 144.178291646496 0.283014804600353 0.330027033121272 0.85755037071874 0.391140789559891 0.591600438191876 Cysteine desulfurase IscS (NIFS protein homolog) (nitrogenase metalloclusters biosynthesis protein NIFS) IV.H - Miscellaneous transferases Rv3026c - 6.8 5.7 5.1 2.7 0 6.07185282787346 -1.34819710249921 1.26681647864824 -1.06424026307094 0.287219871694071 NA hypothetical protein IV.H - Miscellaneous transferases Rv3027c - 13.1 3.7 7.7 9.4 8 15.5647691776333 0.851035630473781 0.797962688565049 1.06651055578071 0.286192909554634 0.482942013169372 GCN5-related N-acetyltransferase VI - Unknowns Rv3028c fixB 249.9 169.4 128.3 201 25.3 257.48621206088 -0.1382268970719 0.354620464788407 -0.389788268859147 0.696693119119986 0.831711165461068 Probable electron transfer flavoprotein (alpha-subunit) FixB (alpha-ETF) (electron transfer flavoprotein large subunit) (ETFLS) I.B.6.c - Electron transport Rv3029c fixA 477.7 336 233.1 413.1 162.6 520.707214459639 0.541059123644027 0.259583713623984 2.08433385935671 0.0371298094919627 0.112117463956123 Probable electron transfer flavoprotein (beta-subunit) FixA (beta-ETF) (electron transfer flavoprotein small subunit) (ETFSS) I.B.6.c - Electron transport Rv3030 - 34.9 33.5 24.7 9.4 7.2 33.9274210472034 -1.16836927721729 0.617440129018511 -1.89227946533786 0.0584537554342527 0.157567124618054 hypothetical protein V - Conserved hypotheticals Rv3031 - 25.9 20.3 13.7 7 2.5 37.6259618056221 -1.35490766131334 0.550108115660032 -2.4629843166151 0.0137785942743604 0.0515408519163962 hypothetical protein V - Conserved hypotheticals Rv3032 - 45 34 19.7 7.1 4 46.2135773910004 -1.83792210983453 0.538100042044843 -3.41557696752858 0.000636470395575829 0.00425354366250865 Alpha (1->4) glucosyltransferase V - Conserved hypotheticals Rv3032A - 18.3 7.2 9.5 3.2 0.3 4.14452931433077 -1.78908680729018 1.49161516216229 -1.19942921785313 0.230361092232598 NA hypothetical protein ? Rv3033 - 16.5 17.9 12 10.2 10.8 16.5353613847144 0.318018543994528 0.806842460918345 0.394151968195328 0.693468844960312 0.830220960237125 hypothetical protein VI - Unknowns Rv3034c - 64.2 35.2 25.4 37.5 21.8 66.2257100557831 0.386356565174266 0.439221545944831 0.879639372752435 0.379054702408933 0.579461267126646 Possible transferase V - Conserved hypotheticals Rv3035 - 32 17.7 11.2 22.9 6.2 34.4326798796867 0.280297187428205 0.540773093239186 0.518326800893973 0.604230276749963 0.76571865482947 hypothetical protein VI - Unknowns Rv3036c TB22.2 54.8 32.6 24 35.5 5.4 35.4307047188567 -0.132138757039946 0.549681632594391 -0.240391436068687 0.810026816617698 0.900180115344522 Probable conserved secreted protein TB22.2 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3037c - 55 34.3 24.4 18.6 9.2 54.6839657705081 -0.650133283358009 0.464991367068699 -1.39816205074181 0.162064409836782 0.328359696476486 hypothetical protein VI - Unknowns Rv3038c - 199.4 130.2 82.5 84.7 18.4 172.909394216379 -0.691575591322303 0.334785687155107 -2.06572627760486 0.0388543326176223 0.116333090559271 hypothetical protein VI - Unknowns Rv3039c echA17 80.3 46.9 32.6 23.9 7.9 49.6677231816716 -0.958712303153284 0.480345849377629 -1.9958792282591 0.0459470701903066 0.131670325739536 Probable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase) I.A.3 - Fatty acids Rv3040c - 45 26 19 7.5 2 26.9558929322421 -1.94399557636468 0.65701606735571 -2.95882501654589 0.00308814399602915 0.0155814900768308 hypothetical protein VI - Unknowns Rv3041c - 61 30.2 28.7 21.7 18.4 54.9097885352304 -0.100961531697482 0.505732076454231 -0.199634423834335 0.841766503345283 0.91350881138875 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv3042c serB2 184 93 75.3 76.6 13 180.68975317285 -0.698309930946186 0.348868934633132 -2.00163976101949 0.0453234894373617 0.130199350841148 Probable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase) I.D.3 - Serine family Rv3043c ctaD 176 109.6 73.9 119.6 34.3 325.238723819078 0.111208390876815 0.27550819038992 0.403648220836647 0.68647142078014 0.826753407821576 Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1) I.B.6.a - aerobic Rv3044 fecB 141.5 75.7 68.7 84.9 39 172.704553709241 0.21141346851179 0.322040818830561 0.656480347055084 0.51151510856644 0.696037846539504 Probable FEIII-dicitrate-binding periplasmic lipoprotein FecB III.A.2 - Cations Rv3045 adhC 402.2 267.4 250.4 164.7 97.8 478.204562895159 -0.313878878162117 0.309615637567399 -1.0137694614788 0.310692770458927 0.50736458873468 Probable NADP-dependent alcohol dehydrogenase AdhC I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3046c - 48.9 18.5 21.7 49.7 15.8 22.5762644393686 0.960889649004648 0.641121159080074 1.49876452429584 0.133934730868398 0.287325435604102 hypothetical protein V - Conserved hypotheticals Rv3047c - 49.1 42.6 15.5 95.6 11.8 20.919498660596 1.24994606906348 0.714753915790592 1.74877820386742 0.080329365813486 0.199248328929529 Hypothetical protein VI - Unknowns Rv3048c nrdF2 180.8 153.2 76.1 158.3 55.1 236.957162955235 0.428967297368202 0.315587505646108 1.35926578110236 0.174062383175984 0.343853296826176 Ribonucleoside-diphosphate reductase (beta chain) NrdF2 (ribonucleotide reductase small subunit) (R2F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3049c - 334.1 197.9 151.8 270.9 64.7 592.727545907177 0.253574383622235 0.25757836810508 0.984455276612313 0.324891710886861 0.524685545441952 Probable monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3050c - 398.7 215.8 184.5 340.2 90 342.532144463015 0.420456461688619 0.271107607366932 1.550884041109 0.120929475560455 0.267432573280091 Probable transcriptional regulatory protein (probably AsnC-family) I.J.1 - Repressors/activators Rv3051c nrdE 908.2 660.4 480.5 1684.3 791.7 4375.62538835354 1.74572788289755 0.250343082568147 6.9733418035321 3.094994301857e-12 1.56606711673964e-10 Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3052c nrdI 860.3 568.2 554.4 1571.6 874.7 969.095140723172 1.80932040713937 0.28951900368991 6.24940119328834 4.12029299598153e-10 1.32673434470605e-08 Probable NrdI protein I.F.3 - 2'-deoxyribonucleotide metabolism Rv3053c nrdH 2272.5 1885.9 1485.5 3105.1 1390.6 1064.89994503127 1.08348734796224 0.269660555122403 4.01796750537146 5.87022897541458e-05 0.000571218434915342 Probable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH I.F.3 - 2'-deoxyribonucleotide metabolism Rv3054c - 2.1 0 0 3.5 0 0.844813362424942 1.78964942280882 3.11948872604428 0.57369959630475 0.566171101548219 NA hypothetical protein V - Conserved hypotheticals Rv3055 - 37.3 28.2 21.9 11.4 2.7 20.361506272412 -1.355646510892 0.715214638019442 -1.89544010822545 0.0580341192913548 0.156913626358762 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3056 dinP 42.3 36.9 28.1 29 13.4 60.9914741883762 -0.0185177631073921 0.448600765617193 -0.0412789378143727 0.967073523945701 0.986002999946941 Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3057c - 58.3 32 26.3 53 6.8 53.0698188331431 0.302593253085949 0.482626439073839 0.626971977885476 0.530677603836234 0.71091530740845 Probable short chain alcohol dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3058c - 134.9 106.9 93.2 194 99.3 184.860177027861 1.23326056868201 0.339790375263253 3.62947469517505 0.000283998568310997 0.00218678897599468 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3059 cyp136 69.6 62.9 49.6 80.2 38 190.323393637179 0.767664797138086 0.339307569280722 2.2624452462567 0.0236699081204471 0.0791897547681659 Probable cytochrome P450 136 Cyp136 IV.F - Cytochrome P450 enzymes Rv3060c - 237.9 153.4 111.1 201.1 44.8 404.60134412858 0.225583655282619 0.277673246872266 0.812406876872768 0.416558201539536 0.612100983924352 Probable transcriptional regulatory protein (probably GntR-family) I.J.1 - Repressors/activators Rv3061c fadE22 90.5 43.1 57.4 72.5 31.6 259.808981183141 0.516746274760856 0.317709100401902 1.62647615100471 0.103848402742387 0.239629343657025 Probable acyl-CoA dehydrogenase FadE22 I.A.3 - Fatty acids Rv3062 ligB 15.5 10.6 13.8 13.3 3.6 32.1389165523118 -0.00295306659991778 0.578353808744552 -0.00510598625835642 0.995926030098937 0.999311614337233 Probable ATP-dependent DNA ligase LigB (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3063 cstA 12.5 10 5.6 8.4 3.5 34.2360096489674 0.10083776951027 0.543489394338174 0.185537695051186 0.852807317109919 0.919904717299549 Probable carbon starvation protein A homolog CstA III.E - Adaptations and atypical conditions Rv3064c - 43.5 20.9 16 25.6 5.6 16.1877977276145 0.0239133767717589 0.745182929788856 0.032090612674843 0.974399789556551 0.99017882337715 Probable conserved integral membrane protein V - Conserved hypotheticals Rv3065 mmr 62.3 36.9 30.3 70.7 6.1 22.0122950956416 0.41329663896996 0.69851024815034 0.591682999733179 0.554062882600798 0.729550457313021 Multidrugs-transport integral membrane protein Mmr III.A.6 - Efflux proteins Rv3066 - 32.8 11 13.8 11.8 0 12.7577634986346 -0.950774726797833 0.926002913837362 -1.02675133370565 0.304537570566566 0.500580157142463 Probable transcriptional regulatory protein (probably DeoR-family) I.J.1 - Repressors/activators Rv3067 - 34.9 28.9 15.6 19.1 0 12.8115586496897 -0.743628714236292 0.907879751594145 -0.819082827798015 0.412739158611354 0.608950018510016 hypothetical protein V - Conserved hypotheticals Rv3068c pgmA 40.2 29.5 19.3 22.2 14.9 84.1011017491926 0.205467590191642 0.423328136523256 0.485362470539103 0.627419249032746 0.783217666759793 Probable phosphoglucomutase PgmA (glucose phosphomutase) (PGM) I.A.1 - Carbon compounds Rv3069 - 23.9 8.3 9.6 22.2 0 7.9728142494581 0.304126933717092 1.08659794354068 0.27988911218265 0.779562580737885 0.883870249991545 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3070 - 26.4 18 23.4 16.6 5.1 11.5606857110358 -0.47749761066007 0.890824120738398 -0.536017828372536 0.591946228932399 0.758548659309287 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3071 - 13.5 7.9 9.1 7.7 5.4 19.8840448851903 0.182331483589964 0.707862583121771 0.257580338242851 0.796730805597124 0.894459750689386 hypothetical protein VI - Unknowns Rv3072c - 40.3 18.7 13.7 21.1 4.3 16.2104786162823 -0.280414637670712 0.772377902610574 -0.363053677122213 0.716564787337932 0.847091552695191 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3073c - 66.7 34.6 28 20.5 5.5 17.6847286508277 -1.09008944535533 0.748590646696764 -1.45618897346029 0.145340386861977 0.304073036187314 hypothetical protein V - Conserved hypotheticals Rv3074 - 139.5 89.3 63.9 17.7 1.5 124.843874180655 -2.62531479219094 0.453696691042235 -5.78649755227452 7.18691336280539e-09 1.81828908078976e-07 hypothetical protein V - Conserved hypotheticals Rv3075c - 332.1 176.3 130.4 193.9 34.7 275.995991718075 -0.219642491774196 0.31706694437823 -0.692732231059016 0.488477608196587 0.676647512018894 hypothetical protein V - Conserved hypotheticals Rv3076 - 28 9 2 37.8 13 17.3451983400289 1.85817728213722 0.816598588540682 2.27550880960732 0.0228754248115277 0.0771664330308866 hypothetical protein V - Conserved hypotheticals Rv3077 - 16.1 10.7 4.7 8.1 1.1 23.1620516244627 -0.490467552793066 0.694113085192044 -0.706610440368468 0.479808599073469 0.668509204692401 Possible hydrolase I.C.5 - Sulphur metabolism Rv3078 hab 25.2 10.2 6.1 11.6 4.1 7.44731133767347 -0.0489862421897558 1.07821012147815 -0.0454329274173377 0.963762235792512 0.984610856411041 Probable hydroxylaminobenzene mutase Hab II.C.5 - Other membrane proteins Rv3079c - 20.5 14.3 10.1 43.2 17.3 39.4887674314543 1.83675475022519 0.506517328763764 3.62624266914635 0.000287575119942396 0.00220474258622504 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3080c pknK 22.2 16 6.8 28.3 9.1 110.292321964678 1.12000443982178 0.376763995891396 2.97269498156778 0.00295197646964137 0.0151456207016507 Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K) I.J.3 - Serine-Threonine protein kinases and phosphoprotein phosphatases Rv3081 - 9.8 18 3 14.5 5 24.6086286633223 0.748335086044966 0.719089856817982 1.04066978410236 0.29802883135782 0.493740935766791 hypothetical protein VI - Unknowns Rv3082c virS 3.6 5.1 2.4 11.2 1.9 8.74529618099811 1.46613685461242 1.01041830494235 1.4510196890149 0.146774377744984 0.305628951189143 Virulence-regulating transcriptional regulator VirS (AraC/XylS family) I.J.1 - Repressors/activators Rv3083 - 64.3 45.3 26.3 69.4 26.5 140.863368973318 0.903195391566832 0.335498646550604 2.69209846553167 0.00710039785810113 0.0307828754141912 Probable monooxygenase (hydroxylase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3084 lipR 22 19 12.9 18.8 8.6 29.7518580879679 0.345287860972659 0.57397788651886 0.601569971740216 0.547460422157051 0.725085215532262 Probable acetyl-hydrolase/esterase LipR II.B.5 - Esterases and lipases Rv3085 - 29.9 19.1 7.7 29.5 13 33.7311032340481 1.06625815734546 0.565543276766022 1.88536969874827 0.0593799420489038 0.158974871305531 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3086 adhD 109.3 62.9 52.1 108.1 23.7 146.894330766035 0.518152788490012 0.332694668493414 1.55744241660509 0.119365482120723 0.265353174415602 Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3087 - 38.6 9.7 15.6 55 26.1 93.7338503787889 1.82312631020049 0.42625590557417 4.27706991588709 1.89369341363459e-05 0.000222101393082573 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3088 tgs4 40.5 19.2 28.3 100.5 58.6 180.41906513413 2.3490992765069 0.369166714066539 6.3632477875118 1.97531632806223e-10 6.85938277842785e-09 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4 V - Conserved hypotheticals Rv3089 fadD13 47.7 33.1 23.5 112.7 41.8 177.232217695322 1.95565248132878 0.310335507641258 6.30173613130175 2.94329942231557e-10 9.83506278664317e-09 Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) I.A.3 - Fatty acids Rv3090 - 3.4 3.9 3.5 4 3.9 6.69563971823156 0.813813726888093 1.13259313735761 0.718540224238648 0.472424255351049 NA Unknown alanine and valine rich protein VI - Unknowns Rv3091 - 73.6 38.9 42.5 46.3 8.8 125.158576657118 -0.249699616262707 0.370385752781524 -0.674160964312241 0.500208984070443 0.686356542085852 hypothetical protein VI - Unknowns Rv3092c - 239 192.2 80.8 85 27.7 198.90530441974 -0.815502282203162 0.353225596759383 -2.30872929279438 0.0209586077905548 0.072143234979733 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3093c - 98.7 112.3 56 3.2 2.2 89.5399852177549 -4.66262777606552 0.59722378837176 -7.80717022136285 5.84862558600509e-15 5.31175175016155e-13 Hypothetical oxidoreductase VI - Unknowns Rv3094c - 153.6 141.8 67.5 6.5 5 137.04309049822 -3.8359806883047 0.479101604729982 -8.00661206398303 1.1791170117669e-15 1.22836248696422e-13 hypothetical protein V - Conserved hypotheticals Rv3095 - 297.5 343.8 163 21.3 15 135.426910144414 -3.21393619091454 0.480286522680656 -6.69170596954581 2.20583745124577e-11 9.30128125275298e-10 Hypothetical transcriptional regulatory protein I.J.1 - Repressors/activators Rv3096 - 104.8 85.3 47.2 43.9 16.2 121.181629628723 -0.627417935167204 0.364733658451195 -1.72020848811012 0.0853945506681911 0.208024414351261 hypothetical protein VI - Unknowns Rv3097c lipY 5.6 2.7 0.7 3.8 2.3 7.28304765918804 0.889273844861048 1.11402217401653 0.798255066732495 0.424722487477576 0.619591042275773 PE-PGRS family protein, triacylglycerol lipase LipY (esterase/lipase) (triglyceride lipase) (tributyrase) IV.C.1.a - PE subfamily Rv3098c - 11.1 4.8 0 12.9 1.3 3.77436783779513 0.962598188492741 1.6052104779653 0.599671009943126 0.54872551229956 NA Hypothetical protein VI - Unknowns Rv3098A - 349.5 212.5 174.7 242.2 96.8 134.171525714997 0.265775054685729 0.333240405429093 0.797547507312345 0.425133123412949 0.619934756331275 PemK-like protein ? Rv3099c - 126.1 103.9 74.7 113.5 51.9 164.660080193939 0.519574415338213 0.335042338703895 1.55077241087851 0.120956234442322 0.267432573280091 hypothetical protein VI - Unknowns Rv3100c smpB 54.9 22.9 27.4 34.4 17.5 29.9678447916131 0.389412256355886 0.582233468659092 0.668824925596803 0.503607164676242 0.68845101400357 Probable SSRA-binding protein SmpB IV.A - Virulence Rv3101c ftsX 59.2 40.2 41.4 50.8 16.4 71.8114133499929 0.235060744728509 0.41383012320786 0.568012649505561 0.570026378689741 0.741939379119394 Putative cell division protein FtsX (septation component-transport integral membrane protein ABC transporter) III.C - Cell division Rv3102c ftsE 33 29.1 24.1 33.4 13.2 36.2649471562576 0.42603937854608 0.532507954669285 0.800061998718259 0.423674877047701 0.618572306060576 Putative cell division ATP-binding protein FtsE (septation component-transport ATP-binding protein ABC transporter) III.C - Cell division Rv3103c - 58.9 30 40.8 17.9 20.8 29.5676304958045 -0.356306429409709 0.65822368048625 -0.541315118207985 0.588290401794764 0.755794197735602 Hypothetical proline-rich protein VI - Unknowns Rv3104c - 160.1 79.7 63.5 99.7 19.9 136.277341473583 -0.0492037464620028 0.355212547736141 -0.138519167680282 0.889830122021751 0.943363751032937 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3105c prfB 75.4 70.2 52.8 81.4 31.7 145.064345868876 0.522073301261104 0.350318682606169 1.49028107030199 0.136150347664942 0.290159164518185 Probable peptide chain release factor 2 PrfB (RF-2) II.A.6 - Protein translation and modification Rv3106 fprA 19.2 9.3 3.9 8.8 4.2 21.7991455005164 0.0658469817486536 0.68545493433757 0.0960631814727378 0.923470392956174 0.963739579213544 NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) I.B.6.c - Electron transport Rv3107c agpS 19.5 12.2 9.2 9.6 3.3 30.1698900471171 -0.320835932057081 0.567322786707417 -0.565526256964088 0.571715870107502 0.743125729145237 Possible alkyldihydroxyacetonephosphate synthase AgpS (alkyl-DHAP synthase) (alkylglycerone-phosphate synthase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3108 - 1.3 2.7 0.3 0 0 0.497512913536711 -0.930556046292305 3.86806663909191 -0.24057394381157 0.809885346956891 NA Hypothetical protein VI - Unknowns Rv3109 moaA1 11.8 8.8 5.7 3.7 0 10.0386277251771 -1.43126710943063 1.02062408868318 -1.40234502134597 0.160812242361235 0.326603762868977 Probable molybdenum cofactor biosynthesis protein A MoaA1 I.G.4 - Molybdopterin Rv3110 moaB1 13.5 9.2 12.8 4 5 6.07686900896773 -1.04428446189695 1.25007088504094 -0.83538019675 0.403503676223764 NA Probable pterin-4-alpha-carbinolamine dehydratase MoaB1 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD) I.G.4 - Molybdopterin Rv3111 moaC1 10.4 15 1.8 3.2 0 4.55440739980555 -1.62949638354845 1.51372537781416 -1.07648085143519 0.281712260217279 NA Probable molybdenum cofactor biosynthesis protein C MoaC1 I.G.4 - Molybdopterin Rv3112 moaD1 21.8 9 13.2 3.5 0 3.62807325882286 -2.18060330855099 1.58341584520106 -1.37715137508561 0.168465451701227 NA Probable molybdenum cofactor biosynthesis protein D MoaD1 (molybdopterin converting factor small subunit) (molybdopterin [MPT] converting factor, subunit 1) I.G.4 - Molybdopterin Rv3113 - 7.6 4.9 5.8 3.3 0 4.70366839184263 -1.11967253857533 1.39631691214632 -0.801875655043267 0.422624889878635 NA Possible phosphatase VI - Unknowns Rv3114 - 6.6 2.7 0 3.2 0 1.71262736513578 0.127805076815037 2.21278121748575 0.0577576652427727 0.953941660094316 NA hypothetical protein VI - Unknowns Rv3115 - 2 4.1 3.4 3.6 3.2 9.52987532049296 0.88327774498913 1.03006703091488 0.857495404162801 0.39117115365482 0.591600438191876 Probable transposase IV.B.1.b - IS1081 Rv3116 moeB2 156.1 124.1 63.4 110.7 27.8 204.84335482571 -0.0081222356893474 0.327660593552748 -0.0247885642923364 0.980223612629829 0.993121291743379 Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) I.G.4 - Molybdopterin Rv3117 cysA3 147.6 91.6 89.5 219 123.5 263.332808856722 1.55849346810487 0.323397319812195 4.81912920308037 1.44186159826988e-06 2.30048368516753e-05 Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.D.3 - Serine family Rv3118 sseC1 165.1 83.1 53.8 147.5 61.5 61.8666377638262 0.884196596772927 0.436616719113841 2.02510934205061 0.0428561378469546 0.124935341772768 Conserved hypothetical protein SseC1 I.C.5 - Sulphur metabolism Rv3119 moaE1 90.5 93 33.2 36 3 36.4043862246218 -1.16046486262142 0.629262710612714 -1.84416594698814 0.0651589594495412 0.169292287667862 Probable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2) I.G.4 - Molybdopterin Rv3120 - 58.6 22.4 37.9 18.1 9.9 32.7576442135378 -0.752336101905451 0.599728499687731 -1.25446114749788 0.209674439077165 0.390056125636197 hypothetical protein IV.H - Miscellaneous transferases Rv3121 cyp141 63.5 45 38.3 15.2 7.1 71.6904750311294 -1.41109330348857 0.440750258164335 -3.20157113319817 0.00136680323922094 0.00808216539786405 Probable cytochrome P450 141 Cyp141 IV.F - Cytochrome P450 enzymes Rv3122 - 89.9 85.9 60.1 13.1 4.2 39.7868307939982 -2.58066386603247 0.607922709753534 -4.24505257761917 2.18542171058268e-05 0.000250510152067439 Hypothetical protein VI - Unknowns Rv3123 - 22.9 5.7 2.2 8.4 0 4.90735113741549 -0.315511845657595 1.44015140105359 -0.21908241413144 0.826585849510722 NA Hypothetical protein VI - Unknowns Rv3124 moaR1 4.3 2.4 3 6.3 3.3 7.15304775920409 1.25191619392899 1.06994757104146 1.17007246692509 0.241971807424869 NA Transcriptional regulatory protein MoaR1 I.J.1 - Repressors/activators Rv3125c PPE49 18.4 13.2 12.4 15.4 0.1 22.9036689844721 -0.350162619265574 0.738800001796071 -0.473961313500685 0.635527494938368 0.789364399640414 PPE family protein PPE49 IV.C.2 - PPE family Rv3126c - 16.7 6 8.3 65.8 9.7 12.39598902665 2.52476981108985 0.888909910776434 2.84029886547732 0.00450712855809648 0.0210332666044502 Hypothetical protein VI - Unknowns Rv3127 - 4587.1 2008.9 3045.6 6268.2 1790.9 7472.31820303646 1.01556978902296 0.279246341849026 3.63682396803616 0.000276020424920172 0.00213463830800709 hypothetical protein V - Conserved hypotheticals Rv3129 - 12.6 6.8 4.3 8.4 0 3.15198594147764 -0.155884183497297 1.61648821414264 -0.0964338509451961 0.923176008228635 NA hypothetical protein V - Conserved hypotheticals Rv3130c tgs1 4990.7 2197.8 3021.2 11203.2 3662.8 15496.2046247904 1.88193714904893 0.2615175913359 7.19621628294872 6.19064052211826e-13 3.71648283548185e-11 Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1 V - Conserved hypotheticals Rv3131 - 3489.5 1431.9 2490.8 2947.9 1024.9 4526.24284987541 0.434906234792809 0.301247059081784 1.44368624250947 0.148827253041328 0.308452972657919 hypothetical protein V - Conserved hypotheticals Rv3132c devS 1016.4 478 628.5 968.3 365.9 2449.32847304231 0.715189979321168 0.264235380062429 2.70663973595131 0.00679679714825831 0.0297580414080728 Two component sensor histidine kinase DevS I.J.2 - Two component systems Rv3133c devR 2048.3 907.6 1342.8 1873.5 627 1770.12889470587 0.550450066708058 0.279998030804291 1.96590692129833 0.0493093634256781 0.138614099407739 Two component transcriptional regulatory protein DevR (probably LuxR/UhpA-family) I.J.2 - Two component systems Rv3134c - 3071 1413.1 2011.2 2583.1 636.7 2960.14218319412 0.213506317741249 0.280126403640941 0.762178484306378 0.445953485592037 0.640538218153687 Universal stress protein family protein V - Conserved hypotheticals Rv3135 PPE50 251.4 141.4 147.7 390.8 93.2 162.436617068168 1.10364486923329 0.326532366555493 3.37989425328752 0.00072513723602052 0.00475636312960127 PPE family protein PPE50 IV.C.2 - PPE family Rv3136 PPE51 194.6 101.1 95.9 185 50.8 275.434661034777 0.587686149146484 0.282184345000128 2.08263200832851 0.0372847792921647 0.112489512992204 PPE family protein PPE51 IV.C.2 - PPE family Rv3136A - 13.6 5.2 3.1 12.3 0 2.99133345004588 0.630895374074946 1.67407162548867 0.376862832192609 0.706275543959533 NA hypothetical protein ? Rv3137 - 55.5 29.3 27.2 21.9 6.9 38.2302303764221 -0.654536900703196 0.523414965704718 -1.25051239186854 0.211112431458905 0.391676575290697 Probable monophosphatase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3138 pflA 50.3 42.5 26.6 35.3 18.3 75.2719641608543 0.232883135789224 0.419218481387119 0.555517340310607 0.578540852780864 0.748214132474823 Probable pyruvate formate lyase activating protein PflA (formate acetyltransferase activating enzyme) ([pyruvate formate-lyase] activating enzyme) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3139 fadE24 651.6 303.4 409.2 312.7 139.8 976.821100777632 -0.157532553275058 0.287924682378029 -0.547131117672732 0.584288655247921 0.753385663228299 Probable acyl-CoA dehydrogenase FadE24 I.A.3 - Fatty acids Rv3140 fadE23 951.4 464 507.8 728 274.3 1389.74915531217 0.462613983325775 0.247039957439294 1.87262816963306 0.0611197486109544 0.161798318071749 Probable acyl-CoA dehydrogenase FadE23 I.A.3 - Fatty acids Rv3141 fadB4 242 158.5 149.5 70.3 31.3 226.878437985075 -1.08565996524043 0.317374217644676 -3.42075664903539 0.00062447182799798 0.00418124615268212 Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) I.A.3 - Fatty acids Rv3142c - 384.4 268.4 151.6 296 141.7 216.302522406229 0.592396627445782 0.321243347704933 1.84407438061537 0.0651723009985808 0.169292287667862 Hypothetical protein VI - Unknowns Rv3143 - 7 4.5 3.9 8.3 4.9 3.9448594994403 1.13228424895656 1.40426378307952 0.806318771871683 0.420059069377783 NA Probable response regulator I.J.2 - Two component systems Rv3144c PPE52 77.5 72.3 49.2 48 13.8 118.387508051643 -0.407411918921753 0.371768608998526 -1.09587498530132 0.27313348742668 0.468720354876599 PPE family protein PPE52 IV.C.2 - PPE family Rv3145 nuoA 386.1 344.1 165.9 112.8 30.2 135.371078200172 -1.34833809347314 0.383994731034865 -3.51134529851328 0.00044584487468862 0.00315836509229418 Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A) I.B.6.a - aerobic Rv3146 nuoB 246.9 197.5 123.4 100.4 23.1 131.568539645888 -0.924095644264879 0.365091559368749 -2.53113395955431 0.0113694417240254 0.0442047887886915 Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B) I.B.6.a - aerobic Rv3147 nuoC 213.5 220 146.4 52 22.6 165.171420599044 -1.66490513988211 0.375989231323698 -4.42806602205251 9.50817998827303e-06 0.000123816079111997 Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C) I.B.6.a - aerobic Rv3148 nuoD 335.5 357.5 178.5 89.5 26.5 450.913538792239 -1.6316224370947 0.323670161098026 -5.04100356844617 4.63096830393847e-07 8.20144486627503e-06 Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D) I.B.6.a - aerobic Rv3149 nuoE 371.5 225 195.5 63.4 19.7 220.833470329802 -1.93712665539908 0.316367392835779 -6.12302879268157 9.18130955643906e-10 2.82784334338323e-08 Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E) I.B.6.a - aerobic Rv3150 nuoF 287.3 208.7 120.2 53.3 9.8 294.097300270309 -1.98921026555288 0.333173244639852 -5.97049822443919 2.36530157689506e-09 6.70231854828986e-08 Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) I.B.6.a - aerobic Rv3151 nuoG 333.5 225.8 159.9 32.4 8.7 593.56820525018 -2.81896291864001 0.280584774146274 -10.0467422981777 9.49546241278986e-24 2.58714829739244e-21 Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G) I.B.6.a - aerobic Rv3152 nuoH 278.9 218.3 144.3 27.6 7.3 271.631710377 -2.89611622853882 0.336604281581312 -8.60391975685318 7.70388506873328e-18 1.01063558938716e-15 Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) I.B.6.a - aerobic Rv3153 nuoI 433.6 292.5 275 32 27.1 229.466890965606 -2.74316133244114 0.399726070237132 -6.86260300914023 6.76169465474887e-12 3.07050288040006e-10 Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I) I.B.6.a - aerobic Rv3154 nuoJ 331.1 217.4 149.1 31.9 8.4 185.563155328361 -2.77475523067006 0.357215314716033 -7.76773871768585 7.98996617946735e-15 6.90255127016423e-13 Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J) I.B.6.a - aerobic Rv3155 nuoK 425.8 312 332.8 44.9 29.1 119.512119792721 -2.62317828455803 0.443294998883749 -5.91745517356025 3.26960930835508e-09 9.00167735019844e-08 Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K) I.B.6.a - aerobic Rv3156 nuoL 341.9 243.7 130.3 40.6 10.9 466.843809518164 -2.46072439522148 0.306802847288029 -8.0205396298403 1.05281612677405e-15 1.13002264273748e-13 Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L) I.B.6.a - aerobic Rv3157 nuoM 263.8 193.9 137.3 20.7 2 327.118829745148 -3.45602840845921 0.393081809822368 -8.79213517924162 1.46744056712729e-18 2.07906979550595e-16 Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M) I.B.6.a - aerobic Rv3158 nuoN 284.4 173.4 124.4 21.8 6.2 308.656383821702 -3.02660272413991 0.317571524938534 -9.53046002699931 1.56587782925732e-21 3.46646204451839e-19 Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N) I.B.6.a - aerobic Rv3159c PPE53 28.4 28 29.5 18.5 11.5 85.0569164146561 -0.154656613942891 0.463339050034958 -0.333787134780076 0.738540192170135 0.860909445719309 PPE family protein PPE53 IV.C.2 - PPE family Rv3160c - 70 52.2 38.5 44.9 17.6 54.1824919860312 -0.0305543652727998 0.451706014008272 -0.0676421484887299 0.946070502572325 0.976108861086856 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3161c - 125.9 104 77.9 148.2 37.2 220.122219729724 0.525166930254826 0.31094030963261 1.68896381069194 0.0912263653802284 0.218821599985213 Possible dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3162c - 15.7 3.9 1.2 4 0 2.42854280420577 -0.58150721267959 1.99362412979891 -0.291683474325848 0.770528645624203 NA Possible integral membrane protein III.A.2 - Cations Rv3163c - 18.1 14.6 6.7 5.7 0 17.9132560648921 -1.44344167467372 0.825368838905048 -1.74884440341681 0.0803179189951597 0.199248328929529 Possible conserved secreted protein II.C.5 - Other membrane proteins Rv3164c moxR3 32.1 29 18.3 23.1 2 33.490019838245 -0.499152558689799 0.619189506426604 -0.806138594903605 0.420162939970735 0.61532266440267 Probable methanol dehydrogenase transcriptional regulatory protein MoxR3 I.J.1 - Repressors/activators Rv3165c - 20.4 9 5.9 6.7 0 5.85611181831861 -0.959253960552763 1.26901113634306 -0.755906652889643 0.449705164866106 NA hypothetical protein VI - Unknowns Rv3166c - 19.9 7.4 6.8 13.6 2.1 15.0395087241342 0.139401576249392 0.803910418959413 0.173404365662824 0.862333593786785 0.926740289848456 hypothetical protein V - Conserved hypotheticals Rv3167c - 2.5 8.3 1.7 2.6 0 2.99158656933179 -0.88535261878729 1.75792167611924 -0.50363598720836 0.614517198849297 NA Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3168 - 5.4 4.9 2.4 6.6 4.5 12.0617776396026 1.27282941876027 0.863246442929143 1.47446818829782 0.140355576772523 0.296976973075433 Putative aminoglycoside phosphotransferase V - Conserved hypotheticals Rv3169 - 12.6 13.5 5.7 9.5 1.5 16.141090883549 -0.281700600431255 0.783323530663947 -0.359622288114446 0.719129613721734 0.848914653385803 hypothetical protein V - Conserved hypotheticals Rv3170 aofH 22.8 16.8 7.6 14 1.5 26.6328468965215 -0.342934244005403 0.666497850661917 -0.514531657776279 0.60688033270566 0.767594966525107 Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3171c hpx 126.7 47.3 52.8 109.7 16.6 110.813549915467 0.391391470751238 0.406759024891579 0.962219512782936 0.335939349414199 0.537143509595396 Possible non-heme haloperoxidase Hpx III.F - Detoxification Rv3172c - 126.3 86.8 76.5 68 32 72.719848850072 -0.160036987938998 0.418791915389023 -0.382139630824385 0.70235779730306 0.836781472602569 Hypothetical protein VI - Unknowns Rv3173c - 811.7 461.4 354.1 189 83.7 394.83222205134 -1.15256216581257 0.281258628788722 -4.0978730884675 4.1696377226347e-05 0.000436372797143511 Probable transcriptional regulatory protein (probably TetR/AcrR-family) I.J.1 - Repressors/activators Rv3174 - 2.6 2 0 0 0 0.76906704559774 -1.80044755322574 3.24851379446115 -0.554237311934948 0.579416446070366 NA Probable short-chain dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3175 - 2.4 0 1.8 0.3 0 1.9769740557598 -2.27054789116266 2.14056042289294 -1.06072590471146 0.288814483822447 NA Possible amidase (aminohydrolase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3176c mesT 33.4 39.3 17 17.9 8.6 41.2814673210887 -0.457423567711144 0.545982119384376 -0.837799538612938 0.402143297932344 0.600502344551586 Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase) II.B.5 - Esterases and lipases Rv3177 - 2.1 2 2.5 0.8 0 1.77843528038565 -1.43682267199877 2.05788588852551 -0.698203277455907 0.485050077116205 NA Possible peroxidase (non-haem peroxidase) III.F - Detoxification Rv3178 - 0.3 0 1.2 1.1 0 0.0854208528060269 2.09694716487919 4.43926588087807 0.472363499089273 0.636667353215063 NA hypothetical protein V - Conserved hypotheticals Rv3179 - 5.3 3.4 2.9 13.5 1.8 13.0411076976549 1.72861199689534 0.822656713105064 2.10125556548467 0.0356185380658781 0.108292585261236 hypothetical protein V - Conserved hypotheticals Rv3180c - 13.8 13.6 11 4.8 4.5 7.14398958454011 -1.04025339025301 1.14364419084173 -0.909595308211536 0.363035973852231 NA Hypothetical alanine rich protein VI - Unknowns Rv3181c - 27.3 20.9 2.9 16.7 0 9.23171600637306 -0.275585547960536 1.09602947224921 -0.251439906442475 0.801474017592526 0.896375424790883 hypothetical protein V - Conserved hypotheticals Rv3182 - 199.1 140.6 87.7 141.2 43.5 78.0256483539095 0.12809373070003 0.395076901372102 0.32422480346272 0.745767845033778 0.864934416211408 hypothetical protein V - Conserved hypotheticals Rv3183 - 18.9 10 5.6 13.9 2.5 4.56837243527411 0.0485190096933676 1.37986435500607 0.0351621588870988 0.971950436393055 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3184 - 9 17.1 6.4 14.1 0 4.88835318664618 0.0419214044374569 1.36021725193321 0.0308196388318675 0.975413378335797 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3185 - 6.5 8.3 2.4 5.2 0 6.65806309698146 -0.305960096285725 1.19946436538359 -0.255080605239888 0.798660843566713 NA Probable transposase IV.B.1.a - IS6110 Rv3186 - 16.3 11 6.9 8 5.6 5.26760139558633 -0.118292857703494 1.25023757029405 -0.0946163037443134 0.924619599418792 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3187 - 5.7 8 5.3 4.4 0 7.58226129156632 -0.858094940881883 1.14572879526871 -0.748951186725328 0.453886627016183 0.64825259390779 Probable transposase IV.B.1.a - IS6110 Rv3188 - 7.5 8.7 7.3 25.3 11.2 9.39442424654096 2.15385648442166 0.972268006771498 2.2152909171348 0.026740102881905 0.0869728598785193 hypothetical protein V - Conserved hypotheticals Rv3189 - 9.4 12.4 5.9 23.8 22.5 24.6327027822374 2.39167645650678 0.701803613976425 3.40789988663 0.00065464908307141 0.00435040722746517 hypothetical protein V - Conserved hypotheticals Rv3190c - 33.4 30 11.9 20.5 13 56.3170778322514 0.348483582310605 0.497915683764257 0.699884726819727 0.483999296358409 0.672020975186784 Hypothetical protein VI - Unknowns Rv3190A - 502.1 423.6 245.7 184.3 90.9 112.05107236006 -0.700345839937255 0.386784762016225 -1.81068622322789 0.070189436632138 0.178856823418009 hypothetical protein ? Rv3191c - 0.5 7 5.2 0 0 5.01920352634147 -4.59938366750249 1.88710261072124 -2.43727269591591 0.014798514750498 NA Probable transposase IV.B.1.c - Others Rv3192 - 2.9 3.7 0 3.5 0 1.15815846604253 0.840130382279022 2.55212469515809 0.32918861052241 0.742013131125496 NA Conserved hypothetical alanine and proline-rich protein VI - Unknowns Rv3193c - 172 107.8 107.7 116 63.7 696.948865669525 0.383304152808707 0.291391526475488 1.31542655836614 0.188366584628514 0.363197845810667 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3194c - 32.9 9.9 12.4 29.4 5.7 31.7431175882012 0.632437846760221 0.592844887223777 1.06678468582542 0.286069075464884 0.482942013169372 Possible conserved secreted protein V - Conserved hypotheticals Rv3195 - 23.1 11.2 9.8 15.9 1 27.8651589689354 -0.138518855141793 0.64828824568935 -0.213668620498434 0.830805483425565 0.910774689660585 hypothetical protein V - Conserved hypotheticals Rv3196 - 2.4 0.3 2.9 2.2 2.7 4.86338303573319 1.28340730760509 1.41160909838753 0.909180387878709 0.363254914800257 NA hypothetical protein VI - Unknowns Rv3196A - 29.5 11.3 36.8 25.8 15.5 9.55083924574494 0.259293016164118 0.995812428131601 0.260383390324439 0.794568053798772 0.89373135806772 hypothetical protein ? Rv3197 - 657.3 443.2 332.7 428.3 158.1 1037.56150710642 0.092633983039635 0.236871348820526 0.391072974848564 0.695743296052053 0.831137522636213 Probable conserved ATP-binding protein ABC transporter II.C.5 - Other membrane proteins Rv3197A whiB7 18.9 7.5 5.5 31.4 15.5 9.32600962411079 1.89117888063501 0.967232871499833 1.9552467005205 0.0505539588622954 0.140993797078937 Probable transcriptional regulatory protein WhiB-like WhiB7 ? Rv3198c uvrD2 44.6 26.2 20.8 30.4 5.7 94.779793908073 -0.0602130820278454 0.386419619561162 -0.15582304567306 0.876172504691899 0.93588751858224 Probable ATP-dependent DNA helicase II UvrD2 II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3198A - 33.4 9.4 13.7 49 17 12.2471852372531 1.54234536546763 0.849128063726252 1.81638722279336 0.0693109938053545 0.17712809528035 Possible glutaredoxin protein ? Rv3199c nudC 49.1 15.5 26.8 28.5 6.3 42.1802701191166 -0.0933919022191518 0.530898562136192 -0.175912893497711 0.860362375767046 0.925137685175129 Probable NADH pyrophosphatase NudC (NAD+ diphosphatase) (NAD+ pyrophosphatase) (NADP pyrophosphatase) V - Conserved hypotheticals Rv3200c - 85 67.6 50 31.9 6.9 88.8732074370358 -1.09638286203963 0.408968893365029 -2.68084658717807 0.00734361739622997 0.031654189330797 Possible transmembrane cation transporter II.C.5 - Other membrane proteins Rv3201c - 8.7 3.7 4.1 1.9 0.9 21.1346951419737 -1.26409535752875 0.701049277716135 -1.80314764982984 0.0713650294690465 0.180553524556688 Probable ATP-dependent DNA helicase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3202c - 13.4 6 4.8 2.5 0 25.1942683835742 -1.84520904406641 0.735334544749761 -2.50934633391166 0.012095482915543 0.0466690637111692 Possible ATP-dependent DNA helicase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3203 lipV 17.6 1.9 8.4 18.6 11.2 17.3292905501376 1.55515233021141 0.788701429343562 1.97178840097421 0.048633767001894 0.137150320637507 Possible lipase LipV II.B.5 - Esterases and lipases Rv3204 - 30.4 1.8 8.2 23.6 7.4 6.63239582220447 0.917095044784954 1.23278561433061 0.743920949534222 0.456924300487277 NA Possible DNA-methyltransferase (modification methylase) IV.H - Miscellaneous transferases Rv3205c - 203 115 107.7 133.2 35.4 191.403331898066 -0.0321303397537411 0.307805062815193 -0.104385351754374 0.916863546780586 0.959388680264944 hypothetical protein VI - Unknowns Rv3206c moeB1 177.4 85.5 78.2 130.9 56 247.330602910776 0.567822912332347 0.297236953964577 1.91033754302306 0.0560897668641252 0.152940688400871 Probable molybdenum cofactor biosynthesis protein MoeB1 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) I.G.4 - Molybdopterin Rv3207c - 400.2 319.5 222 262.5 107.2 435.937670572192 0.0328117975497851 0.276522007951875 0.118658900941785 0.905545598727206 0.953325419995372 hypothetical protein VI - Unknowns Rv3208 - 165 112.7 82.8 84.2 23 114.353179510093 -0.429731510001193 0.354673507780593 -1.21162562349323 0.225655721504087 0.409463404491534 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3208A TB9.4 81.4 36.9 32.5 48.6 21.3 21.6539782798495 0.234382752713148 0.652518588319298 0.359197051101412 0.719447682510639 0.848914653385803 Conserved protein TB9.4 ? Rv3209 - 182.4 79.9 70.2 131.6 32.7 100.754936705848 0.314923588952492 0.375396975614024 0.838908167646748 0.401520844096147 0.600078831134411 Conserved hypothetical threonine and proline rich protein V - Conserved hypotheticals Rv3210c - 64.5 32.6 27.7 21.5 14.2 41.6897988502487 -0.392623997777784 0.530356677972956 -0.740301789502128 0.459116895376546 0.652503806127907 hypothetical protein VI - Unknowns Rv3211 rhlE 665.5 440.3 367 288 107.8 1084.20024271727 -0.522492321301538 0.23948464552986 -2.18173620336086 0.0291290073658759 0.0926166464002983 Probable ATP-dependent RNA helicase RhlE II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3212 - 531.3 300.4 216.2 128.3 32.2 488.434532268858 -1.37927713638648 0.273330417231326 -5.04618970094049 4.50707925315817e-07 8.02214809783227e-06 Conserved alanine valine rich protein VI - Unknowns Rv3213c - 611.5 373.5 223.9 179.9 56.7 392.959309477088 -0.974426279751141 0.28357492147284 -3.43622163303489 0.000589888193781238 0.00397516361838301 Possible SOJ/para-related protein III.C - Cell division Rv3214 gpm2 79.3 45.5 39.3 62.9 9.5 49.3706422526991 0.0506613125346767 0.497164184868961 0.101900567411206 0.91883559957952 0.960690356564489 Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) I.G.14 - Iron utilisation Rv3215 entC 33.8 17.4 23.8 18.9 3.7 37.9005470364775 -0.490643812837822 0.554083000996978 -0.885505983679326 0.375883793793152 0.576611261816926 Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis) I.G.14 - Iron utilisation Rv3217c - 92.4 77.8 51.4 33.4 0 35.384434242193 -1.44575447806291 0.653281404078267 -2.21306540954242 0.0268931364479461 0.0873102560024061 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3218 - 7 3.6 2.1 3.5 0 4.63786047659276 -0.435323740334253 1.3748366733525 -0.316636694941172 0.751519288815336 NA hypothetical protein V - Conserved hypotheticals Rv3219 whiB1 5251.2 3617.7 2887.9 4886.9 2087 1966.11878895574 0.673933170474876 0.24140110038696 2.79175682875752 0.00524227364757966 0.0238972114024802 Transcriptional regulatory protein WhiB-like WhiB1 Contains [4FE-4S]2+ cluster I.J.1 - Repressors/activators Rv3220c - 264 172.1 116 118.5 32.3 372.343892550977 -0.54670203323322 0.273850306756599 -1.99635355427641 0.0458954525625632 0.131628901195626 Probable two component sensor kinase I.J.2 - Two component systems Rv3221c TB7.3 365.9 236.5 158.9 204.2 111.7 91.811938400666 0.175744772477236 0.394603731553173 0.44537027509978 0.656052189806324 0.805868918214254 Biotinylated protein TB7.3 I.H.1 - Synthesis of fatty and mycolic acids Rv3221A rshA 157.1 84.5 72.5 89.7 14.8 42.9229992321584 -0.337366102064077 0.521419964186031 -0.647014163699556 0.517622776734167 0.701653224336939 Anti-sigma factor RshA ? Rv3222c - 188.5 84.4 94.4 90.6 23.5 94.1729208668147 -0.358720627138106 0.385057896687072 -0.931601793456091 0.35154235593213 0.552178724927541 hypothetical protein V - Conserved hypotheticals Rv3223c sigH 187.8 152.3 123.8 135.2 56.1 167.257453600792 0.0637952811530379 0.332580342569554 0.191819157621128 0.847883864008345 0.91718647671135 Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3224 - 234.3 178.6 80.4 81.6 10.5 161.143138693747 -1.18290133408804 0.408324889028857 -2.8969611352896 0.00376796430799808 0.0181499864125725 Possible iron-regulated short-chain dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3224A - 177.7 59.6 45.5 64.1 1.6 18.875532658173 -0.782718119426327 0.815472029848454 -0.959834415868053 0.337138558176832 0.538630930564881 hypothetical protein ? Rv3224B - 138.1 67.7 40 27.2 5.3 18.8127647083689 -1.47979746155417 0.756527967659045 -1.9560380115664 0.0504606764735719 0.140892068046728 hypothetical protein ? Rv3225c - 57.6 28.9 33.3 55.1 14.8 102.549620143813 0.511451789503809 0.369114796943211 1.38561714062765 0.165863841469534 0.332858198963511 GCN5-related N-acetyltransferase, phosphorylase IV.D - Antibiotic production and resistance Rv3226c - 35.4 21.8 14.9 26.7 3.1 26.2427201317799 0.0175003472239017 0.625082895431834 0.0279968422617158 0.977664669671182 0.992231593116139 hypothetical protein V - Conserved hypotheticals Rv3227 aroA 30.8 27 20.5 18.1 5.2 49.3452066045829 -0.515477353697415 0.487456624179151 -1.05748353418204 0.290290965487756 0.486151583809755 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) I.D.4 - Aromatic amino acid family Rv3228 - 27 19.8 16.9 21.1 8.9 36.6726198511727 0.22627529537372 0.525306149027016 0.430749374993672 0.666650613305197 0.813625205151562 hypothetical protein V - Conserved hypotheticals Rv3229c desA3 868.1 369 571.6 1075.4 447.1 1847.81164783586 1.16574540540377 0.293249652331331 3.9752661124612 7.03006034625901e-05 0.000662246642192804 Possible linoleoyl-CoA desaturase (delta(6)-desaturase) I.H.2 - Modification of fatty and mycolic acids Rv3230c - 105.1 44.8 41.8 168.2 47.6 191.97305035083 1.52470075029716 0.314080698779149 4.85448725828671 1.20698629813874e-06 1.95212121826824e-05 Hypothetical oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3231c - 32.9 17 19.1 22.8 2 14.9277440959448 -0.381156319211749 0.852755833386754 -0.446970052022947 0.654896683219617 0.805711723502565 hypothetical protein VI - Unknowns Rv3232c ppk2 70.9 53.1 42.3 57.6 19.2 83.0212599002463 0.210572580034496 0.387884004103113 0.542875132274128 0.587215778849645 0.754961266310505 Polyphosphate kinase Ppk2 (polyphosphoric acid kinase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3233c - 69.5 77.6 37.4 39.7 24.5 58.7036262317597 -0.109969816612706 0.495142873932623 -0.222097140850038 0.824238263554267 0.906099295316329 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3234c tgs3 87.4 82.7 53.3 49.1 17.8 88.3805529050818 -0.420084116775514 0.402994853305603 -1.04240566183348 0.297223642621353 0.493329963526163 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3 V - Conserved hypotheticals Rv3235 - 7.3 6.7 2.5 15.1 8.1 11.5847697140694 1.97253264077459 0.884075972795549 2.23118001333892 0.0256692073379366 0.0842635147274989 Hypothetical alanine arginine proline rich protein VI - Unknowns Rv3236c - 94.2 52 34.1 36.5 8.6 87.756888982622 -0.657690202520659 0.400618955190701 -1.6416851823888 0.100655264035895 0.234091231264044 Probable conserved integral membrane transport protein III.A.2 - Cations Rv3237c - 77.9 41.1 46.2 86.1 22.9 51.0551309099183 0.693832466800084 0.458579074026835 1.51300507610926 0.130278369470868 0.281541174292748 hypothetical protein III.A.2 - Cations Rv3238c - 43.5 11.8 10.6 79.3 14.4 45.2944175049697 1.82099713821012 0.541678763586963 3.36176579297957 0.000774457813697445 0.00496045131304946 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3239c - 14.2 10.4 6.2 13.2 5 61.1538502031787 0.631914729170351 0.428860165189438 1.47347499362926 0.140623001799949 0.297365177537563 Probable conserved transmembrane transport protein II.C.5 - Other membrane proteins Rv3240c secA1 119.3 69.6 60.6 201.2 58.1 602.890095038399 1.37309724919414 0.244945574078091 5.60572386074787 2.07386381630365e-08 4.83264844562338e-07 Probable preprotein translocase SecA1 1 subunit III.D - Protein and peptide secretion Rv3241c - 190.8 148 87.6 192.9 75 181.025214867002 0.715961903854613 0.317983496485161 2.25156937944426 0.0243494979194883 0.080754608268565 hypothetical protein II.A.1 - Ribosomal protein synthesis and modification Rv3242c - 26.4 19.5 7.3 7.9 3.1 13.1328345696659 -1.06704752459411 0.869434655793719 -1.22728892560647 0.219714016467606 0.40280903019061 hypothetical protein V - Conserved hypotheticals Rv3243c - 56.2 21.9 12.4 34.6 9.4 39.0779672407492 0.349764923499502 0.549517081409744 0.636495088746297 0.524453781044984 0.706143777984214 hypothetical protein VI - Unknowns Rv3244c lpqB 164.8 92.8 68.1 78.5 18.8 256.998466422781 -0.434973701374974 0.29863089037646 -1.45655963730556 0.14523797616503 0.304073036187314 Probable conserved lipoprotein LpqB II.C.1 - Lipoproteins(lppA-lpr0) Rv3245c mtrB 195.1 96.1 92 135.9 39.6 355.039148864301 0.214427524813507 0.271169284384033 0.790751523722842 0.429089003094799 0.623393457326405 Two component sensory transduction histidine kinase MtrB I.J.2 - Two component systems Rv3246c mtrA 617 374.2 245.5 545.6 145.7 498.798749125926 0.484243997363342 0.262615135635143 1.84393026773641 0.065193303325512 0.169292287667862 Two component sensory transduction transcriptional regulatory protein MtrA I.J.2 - Two component systems Rv3247c tmk 148.5 79.4 64.3 35.7 11.8 73.1421971399476 -1.27231928139412 0.422562712414223 -3.01095966117076 0.00260423447064428 0.0137469426155321 Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) I.F.3 - 2'-deoxyribonucleotide metabolism Rv3248c sahH 751.3 682.6 345.7 189 94.8 1089.43426776339 -1.17476929218134 0.300910123535161 -3.90405373664362 9.45947630393608e-05 0.00086354291413767 Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) I.C.5 - Sulphur metabolism Rv3249c - 532 472.4 204.6 105.1 34.5 286.014108336718 -1.7706013202144 0.344656923572236 -5.13728638282616 2.78734024027956e-07 5.16898383825665e-06 Possible transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3250c rubB 635.7 467.3 168.9 102.4 20.5 79.8873023651186 -1.99181578303853 0.48940211839967 -4.06989612049843 4.7034104886944e-05 0.000477348995729386 Probable rubredoxin RubB I.B.6.c - Electron transport Rv3251c rubA 1005.5 953.3 482.3 133.1 65 149.343450989069 -2.29263635992233 0.401755124353026 -5.70655163045977 1.15287947241196e-08 2.81620626985045e-07 Probable rubredoxin RubA I.B.6.c - Electron transport Rv3252c alkB 699.2 528.9 289 93.6 35.9 677.679188640535 -2.17447978608613 0.285301942292293 -7.62167887331929 2.50397342737158e-14 1.92805953907612e-12 Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (fatty acid omega-hydroxylase) (alkane hydroxylase-rubredoxin) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3253c - 16.1 9.2 5 4.5 2 18.0787405571473 -0.907994216873713 0.739349955325473 -1.22809802088106 0.219410173896966 0.40280903019061 Possible cationic amino acid transport integral membrane protein III.A.1 - Amino acids Rv3254 - 46.4 33.7 19.4 21 8.3 64.2763224602935 -0.409601310532663 0.434635245439397 -0.942402427853209 0.345986644700367 0.547015054800113 hypothetical protein I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3255c manA 121.1 86.3 60.2 40.4 11.9 135.690747272288 -1.02963009576855 0.346447505581841 -2.97196567785742 0.00295899760743713 0.0151456207016507 Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (phosphohexomutase) I.A.1 - Carbon compounds Rv3256c - 94.2 48 42.7 24.7 13.5 82.1019305741672 -0.91429083915737 0.41496245797472 -2.20330977317729 0.0275729226121553 0.0890276133931214 hypothetical protein VI - Unknowns Rv3257c pmmA 305.2 224.5 149.9 141.6 38 424.689085715524 -0.629438885843867 0.273993861235151 -2.29727367980577 0.0216031622795659 0.0738739489879065 Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase) I.A.1 - Carbon compounds Rv3258c - 154.8 72.7 56.3 122 12 68.8732804198783 0.156815152540041 0.473728570408857 0.331023211044036 0.740626953118564 0.862360508857973 hypothetical protein VI - Unknowns Rv3259 - 10.3 17 0.5 7.1 0 4.18293488984052 -0.493536495444693 1.61817670047229 -0.304995428064591 0.760369634412367 NA hypothetical protein VI - Unknowns Rv3260c whiB2 294.9 127.3 96 679.1 169.4 154.076313974428 2.03900358336203 0.345325508147653 5.90458432769526 3.53536999736559e-09 9.55899277150298e-08 Probable transcriptional regulatory protein WhiB-like WhiB2 I.J.1 - Repressors/activators Rv3261 fbiA 77.8 46.7 40.1 27.6 15.6 77.7292521501729 -0.536016678524967 0.422161707761367 -1.26969516341818 0.20419323630065 0.383891954870967 Probable F420 biosynthesis protein FbiA V - Conserved hypotheticals Rv3262 fbiB 121.4 61.3 89.3 51 18.9 169.417421405492 -0.647332342318937 0.359238887656786 -1.80195509050065 0.0715524715756703 0.1808985398437 Probable F420 biosynthesis protein FbiB V - Conserved hypotheticals Rv3263 - 21.7 13.5 6.5 7.5 1.2 25.8599192257952 -0.943289757315062 0.669929804545283 -1.40804267986752 0.159118432425467 0.324652930674542 Probable DNA methylase (modification methylase) (methyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3264c manB 248.1 118.3 90.9 100.1 27.3 216.188569118247 -0.488712101620881 0.313153831309287 -1.56061351565647 0.118614967855997 0.26423535606663 D-alpha-D-mannose-1-phosphate guanylyltransferase ManB (D-alpha-D-heptose-1-phosphate guanylyltransferase) I.C.3 - Sugar nucleotides Rv3265c wbbL1 143.3 102.7 75.1 48.6 10.5 117.080051763798 -1.13347753046519 0.37130471850211 -3.0526881937773 0.00226801466898787 0.0122458962767607 dTDP-RHA:a-D-GlcNAc-diphosphoryl polyprenol,a-3-L-rhamnosyl transferase WbbL1 (alpha-L-rhamnose-(1->3)-alpha-D-GlcNAc(1->P)-P- decaprenyl) I.C.3 - Sugar nucleotides Rv3266c rmlD 145.5 70.6 43.5 55.5 16.1 102.596558711193 -0.466467298317856 0.389682650697404 -1.19704404977494 0.231289385876374 0.415851271458942 dTDP-6-deoxy-L-lyxo-4-hexulose reductase RmlD (dTDP-rhamnose modification protein) (dTDP-rhamnose biosynthesis protein) (dTDP-rhamnose synthase) I.C.3 - Sugar nucleotides Rv3267 - 206.6 101.6 112.2 79 29.3 285.71994208632 -0.586171149577642 0.295288881106033 -1.98507694357499 0.0471359115671925 0.13431649136846 Conserved protein (CPSA-related protein) V - Conserved hypotheticals Rv3268 - 243.2 118 100.3 91.5 21.5 133.629621723628 -0.698174719878957 0.353437496867845 -1.97538384032867 0.0482246052356899 0.136598145413889 hypothetical protein VI - Unknowns Rv3269 - 1398.4 712.8 733.7 837.3 169.6 383.933398080724 -0.261947023401771 0.294989354852795 -0.887988054797733 0.374547176793648 0.575801258768707 hypothetical protein III.B - Chaperones/Heat shock Rv3270 ctpC 626.2 157.7 270.4 115 11.6 787.819520166391 -1.9578651519002 0.711818081337607 -2.75051337305326 0.0059501962782458 0.0265435708029555 Probable metal cation-transporting P-type ATPase C CtpC III.A.2 - Cations Rv3271c - 93 57.1 33.4 20.9 0.6 41.4991368251477 -1.76163971974661 0.62871175336072 -2.8019831191797 0.00507895311537795 0.0233328818867298 Probable conserved integral membrane protein VI - Unknowns Rv3272 - 197.2 123.6 116.5 39.9 19.5 205.673535550445 -1.52707645280438 0.333260043099821 -4.58223685804115 4.60028404896484e-06 6.49171557826034e-05 hypothetical protein V - Conserved hypotheticals Rv3273 - 179.9 96.5 108 79.9 23.9 403.157344758588 -0.584967428939075 0.280110258449465 -2.08834703940202 0.0367665411131243 0.111210152538588 Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3274c fadE25 102.7 58.4 36.5 80.5 16 121.799243704786 0.254526938632617 0.369495011234945 0.688850812307113 0.490917155767772 0.679229908488066 Probable acyl-CoA dehydrogenase FadE25 I.A.3 - Fatty acids Rv3275c purE 81.7 55.5 52.9 36.6 7.1 42.5949776867512 -0.841358693036955 0.521654258689278 -1.61286652801604 0.1067735085881 0.243680262512276 Probable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AIRC) I.F.1 - Purine ribonucleotide biosynthesis Rv3276c purK 50.1 26.7 23.9 28.6 16.3 74.6354546864892 0.26389654094243 0.418754699981938 0.630193621597114 0.528567911939192 0.708455963476312 Probable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AIRC) I.F.1 - Purine ribonucleotide biosynthesis Rv3277 - 162.2 104.8 76.4 132.7 26.6 148.361495817754 0.159839099670319 0.340864146284446 0.468923180723547 0.639124546363678 0.792118010272337 Probable conserved transmembrane protein V - Conserved hypotheticals Rv3278c - 12.2 1.7 6.6 11 7.6 8.63819487810641 1.3568894992106 1.07358483377894 1.26388661288596 0.206270727438594 0.386362198089635 Probable conserved transmembrane protein V - Conserved hypotheticals Rv3279c birA 17.8 21.2 8.7 7.7 7 19.228729789837 -0.369970561081627 0.756319631487646 -0.489172230468105 0.624719767776753 0.781527727842713 Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligase) I.G.1 - Biotin Rv3280 accD5 174.6 133.5 109.3 113.7 57.1 388.916039094277 0.1439406114091 0.297618544550082 0.48364127183909 0.628640478959992 0.784029780449398 Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) I.H.1 - Synthesis of fatty and mycolic acids Rv3281 accE5 226.4 216.7 209.1 138.2 41.2 166.295259746271 -0.638844290318216 0.370087736563425 -1.72619686415557 0.0843120020173082 0.206325763174091 Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (epsilon chain) AccE5 V - Conserved hypotheticals Rv3282 - 144 109.5 102.5 33.6 8.2 90.3653137146603 -1.84246746229256 0.429755714166737 -4.28724366321683 1.80903825006266e-05 0.000212877524309699 hypothetical protein V - Conserved hypotheticals Rv3283 sseA 480.5 288 258.7 314.7 106 490.14347490128 0.0634265442296873 0.253818735665254 0.249889134714376 0.802673085964555 0.896651270000447 Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) I.C.5 - Sulphur metabolism Rv3284 - 450.9 269.9 235.1 308.6 96.6 220.691045186268 0.0986406229871705 0.291394111324293 0.338512753531224 0.734976817864761 0.858428075587582 hypothetical protein V - Conserved hypotheticals Rv3285 accA3 573.8 257.4 271.3 412.5 129.2 1121.94763191951 0.335874331659262 0.246902434800461 1.36035244824826 0.173718418522133 0.343592386212569 Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP) I.H.1 - Synthesis of fatty and mycolic acids Rv3286c sigF 93.1 47.2 55.5 152.7 33.9 118.384615755819 1.18497653970308 0.362657884332977 3.2674776721939 0.00108510425322598 0.00664954890125676 Alternative RNA polymerase sigma factor SigF II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3287c rsbW 128.5 73.5 91.7 256.2 44.1 101.33308049777 1.20451977871529 0.401832368336481 2.99756782586182 0.00272143293712424 0.0142172794443865 Anti-sigma factor RsbW (sigma negative effector) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3288c usfY 249.5 62.4 139.1 1150.8 241.5 332.050669520049 2.8416948378019 0.365799059985452 7.76845855731534 7.94469904440188e-15 6.90255127016423e-13 Putative protein UsfY V - Conserved hypotheticals Rv3289c - 393.5 80.7 184.7 1482.5 356.1 415.592198045672 2.77315561291766 0.371355897089594 7.46764932145026 8.16400610782082e-14 5.66998228115712e-12 Possible transmembrane protein VI - Unknowns Rv3290c lat 1201.2 417.8 756.4 2587.2 919.5 3584.89960805189 1.93414649313499 0.306629815069102 6.30775742632566 2.8310745666525e-10 9.64198664911843e-09 Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) IV.D - Antibiotic production and resistance Rv3291c lrpA 37.9 27.8 12.6 34.2 30 30.0665618833855 1.29196823217938 0.626334267800111 2.06274556351067 0.0391368084693823 0.116882441482759 Probable transcriptional regulatory protein LrpA (Lrp/AsnC-family) I.J.1 - Repressors/activators Rv3292 - 35.5 16.5 22 49.7 8.1 60.6718635321404 0.854385599389546 0.4664557325949 1.83165419500064 0.0670029570144673 0.17285103695939 hypothetical protein V - Conserved hypotheticals Rv3293 pcd 65.9 28.2 33.2 44.8 7.7 92.7546661884436 -0.0298275868044762 0.411306043950393 -0.0725192037491034 0.942188723322576 0.973691654363404 Probable piperideine-6-carboxilic acid dehydrogenase Pcd (piperideine-6-carboxylate dehydrogenase) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3294c - 1.1 0 1.3 0 0 0.460544931099306 -1.047364495413 3.97249754708454 -0.263653906138136 0.79204661658992 NA hypothetical protein ? Rv3295 - 610.6 458.4 277.1 181.6 82.9 381.831635362531 -0.928584775282075 0.295258284045757 -3.14499143786316 0.00166091690895024 0.00945814741398993 Probable transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3296 lhr 51 44.8 22.1 11.7 3.5 203.361356673426 -1.63048842421711 0.350427364887643 -4.65285701857185 3.27367254100722e-06 4.78667622164462e-05 Probable ATP-dependent helicase Lhr (large helicase-related protein) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3297 nei 38.9 30 17.6 7.2 0 22.5700466304605 -2.18119208436982 0.77138902004772 -2.82761619323398 0.00468959934390591 0.0217012918068902 Probable endonuclease VIII Nei II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3298c lpqC 25.6 25 13.8 4.5 0.6 20.0995886017382 -2.44987911644315 0.827458710037737 -2.96072672475877 0.00306914129677404 0.0155298549616766 Possible esterase lipoprotein LpqC II.C.1 - Lipoproteins(lppA-lpr0) Rv3299c atsB 70.4 47.6 40.5 21.7 8.1 194.832819882672 -1.06770312791392 0.317478064937686 -3.36307684161892 0.000770789054865389 0.00494589643538625 Probable arylsulfatase AtsB (aryl-sulfate sulphohydrolase) (sulfatase) I.C.5 - Sulphur metabolism Rv3300c - 56.1 30.8 24.4 30.3 2 41.9124768159328 -0.574057012207138 0.578509906381908 -0.992302821221128 0.32104982750622 0.519962729321916 hypothetical protein I.G.9 - Riboflavin Rv3301c phoY1 138.1 94.1 79.8 115.1 40 121.006483560972 0.327900481400461 0.3424457753066 0.957525263983426 0.338302200965054 0.53947231466201 Probable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1 III.A.4 - Anions Rv3302c glpD2 56.1 39.7 26.5 39 16.4 121.945307136687 0.25231715401239 0.348399922101793 0.724217021893219 0.468932509953958 0.660421053780088 Probable glycerol-3-phosphate dehydrogenase GlpD2 I.B.6.a - aerobic Rv3303c lpdA 45.1 34.5 23.2 35.1 1.3 67.3492377118137 -0.421401020824828 0.545532579525682 -0.772458028430161 0.439843196438997 0.633906393910052 NAD(P)H quinone reductase LpdA I.B.2 - Pyruvate dehydrogenase Rv3304 - 30.5 7.2 14 21.9 0 10.8079277719499 0.0112448781327816 0.989349701991959 0.0113659286601503 0.990931496254736 0.996155108273772 hypothetical protein V - Conserved hypotheticals Rv3305c amiA1 70.8 26.6 30.9 31 5.1 64.2635625372203 -0.51775552678776 0.463738406088415 -1.11648187855514 0.264215922794175 0.4582617803998 Possible N-acyl-L-amino acid amidohydrolase AmiA1 (N-acyl-L-amino acid aminohydrolase) II.B.3 - Proteins, peptides and glycopeptides Rv3306c amiB1 127.1 43.8 63.1 39 8.3 110.978585950223 -0.996992305903696 0.409360710985443 -2.43548606192241 0.014871797536838 0.0550427449064578 Probable amidohydrolase AmiB1 (aminohydrolase) II.B.3 - Proteins, peptides and glycopeptides Rv3307 deoD 159.5 79.3 82.4 54.1 31.2 122.498645156695 -0.474437487613125 0.379029347672628 -1.2517170254133 0.21067299401958 0.391502489410993 Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) I.F.4 - Salvage of nucleosides and nucleotides Rv3308 pmmB 32.9 16 17.7 4.7 4.9 43.3109997793477 -1.52179137236901 0.587917864965354 -2.58844213291374 0.00964111444192034 0.0384558866591012 Probable phosphomannomutase PmmB (phosphomannose mutase) I.A.1 - Carbon compounds Rv3309c upp 6.9 2.4 4.3 6.8 0.2 3.89059409274949 0.266958441891384 1.47902304028662 0.18049647275248 0.856762823257547 NA Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv3310 sapM 51.6 43 23.5 41.6 26 70.6460592548366 0.666039729055639 0.443729285694402 1.50100466777472 0.133354354268033 0.286607375355952 Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3311 - 51.6 39.3 18.1 26.7 19.3 79.2243082323201 0.288089197131086 0.453833637011142 0.634790314416498 0.525565181062071 0.706862515996735 hypothetical protein V - Conserved hypotheticals Rv3312c - 35.1 18.9 23.8 12.9 2.1 28.171938014027 -1.16423880350779 0.647964854129751 -1.79676227203931 0.0723733682224093 0.182582956014084 hypothetical protein V - Conserved hypotheticals Rv3312A - 278.1 173.9 187.2 73.3 50 88.7564067813764 -0.994392738438229 0.43943135039751 -2.26290804590683 0.0236413583150149 0.0791897547681659 Secreted protein antigen ? Rv3313c add 22.1 22.7 9.5 14.9 1.2 25.8061563764652 -0.486446723154443 0.679471082776885 -0.715919684420442 0.474040943070849 0.663395108793737 Probable adenosine deaminase Add (adenosine aminohydrolase) I.F.4 - Salvage of nucleosides and nucleotides Rv3314c deoA 26.3 17.2 9.2 11.3 4.4 30.5020825974864 -0.41883793388887 0.577148639684161 -0.725702020398202 0.468021462947566 0.660187981585137 Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) I.F.4 - Salvage of nucleosides and nucleotides Rv3315c cdd 14.7 27.8 1 8.5 0 6.19570781392977 -0.916379652021122 1.4483028537249 -0.632726538972343 0.526912236044098 NA Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) I.F.4 - Salvage of nucleosides and nucleotides Rv3316 sdhC 72.8 42.3 24.2 62.9 34.3 32.6863135031767 0.934122976450543 0.560652314613089 1.66613594932751 0.0956863397372891 0.226707605941319 Probable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3317 sdhD 59.8 54.3 27.9 47.4 21.3 35.2347274256437 0.32044468590474 0.540954368708675 0.592369161690442 0.553603412034569 0.729216543483244 Probable succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3318 sdhA 52 20.2 28.3 38.6 10.8 99.2326879725764 0.298803874403688 0.387025487526686 0.772052187862912 0.440083518527616 0.633906393910052 Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3319 sdhB 102 76.7 35.5 46.9 24.7 85.1103832407246 -0.129975627652388 0.421965145059523 -0.308024558838986 0.758063645028489 0.874043434469697 Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase) I.B.3 - TCA cycle Rv3320c vapC44 208.8 150.7 93.9 37.2 15.3 72.3271108572973 -1.79701703221675 0.443866604905218 -4.04855200269116 5.15354843291159e-05 0.000511312844520248 Possible toxin VapC44 Contains PIN domain V - Conserved hypotheticals Rv3321c vapB44 218.2 119.8 78.5 54.8 29.2 42.5907242515595 -0.90164904473907 0.528335266770275 -1.70658500662065 0.0878992139167614 0.212228367889004 Possible antitoxin VapB44 V - Conserved hypotheticals Rv3322c - 25.8 5 6.7 8.4 3.2 9.34162405850809 -0.426438168718483 1.00544270199132 -0.424129756846319 0.671471185099225 0.817302727704967 Possible methyltransferase I.G.4 - Molybdopterin Rv3323c moaX 54.5 18.1 17.3 40.5 11.8 33.9578283087816 0.593962415512782 0.560968676145533 1.05881565365459 0.28968374320933 0.485593856340486 Probable MoaD-MoaE fusion protein MoaX I.B.4 - Glyoxylate bypass Rv3324c moaC3 13.4 9.7 3.8 9 0 5.88718339274839 -0.291639042192747 1.24317608399855 -0.234591902101848 0.814525495366542 NA Probable molybdenum cofactor biosynthesis protein C 3 MoaC3 I.G.4 - Molybdopterin Rv3325 - 18.3 0.5 8.9 16.2 6 5.52085131683765 0.867666694505473 1.28716010102858 0.674093839462636 0.500251655904668 NA Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3326 - 5.3 3.5 7.5 4 0 6.76498988151999 -0.802334504083937 1.22404043457416 -0.655480392167818 0.512158506669306 NA Probable transposase IV.B.1.a - IS6110 Rv3327 - 5.8 5.8 2 3.7 1.2 10.4417554267885 -0.205673119597949 0.930492782518349 -0.221036770474782 0.825063802286166 0.906459844942564 Probable transposase fusion protein IV.B.1.c - Others Rv3328c sigJ 107.3 43 48.7 32.6 8.4 75.1251454875066 -0.959854462026505 0.430945005450403 -2.22732471634823 0.0259255798151339 0.0848691346628506 Probable alternative RNA polymerase sigma factor (fragment) SigJ II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3329 - 47.2 22.6 25.5 24.5 7.5 60.3457413330378 -0.252650818434996 0.440545054762814 -0.573495981179544 0.566308919414698 0.738415274699507 Probable aminotransferase IV.H - Miscellaneous transferases Rv3330 dacB1 38.1 20.9 16.5 10.6 3.2 36.1901544890232 -1.11867573105007 0.546675275941501 -2.04632581768666 0.040724325220739 0.120204633276548 Probable penicillin-binding protein DacB1 (D-alanyl-D-alanine carboxypeptidase) (DD-peptidase) (DD-carboxypeptidase) (PBP) (DD-transpeptidase) (serine-type D-ala-D-ala carboxypeptidase) (D-amino acid hydrolase) II.C.3 - Murein sacculus and peptidoglycan Rv3331 sugI 25.2 17.1 12.2 12.9 2.9 35.8311722790177 -0.495484645695978 0.54340174266744 -0.911820126420191 0.361863413671016 0.563013783263851 Probable sugar-transport integral membrane protein SugI III.A.3 - Carbohydrates, organic acids and alcohols Rv3332 nagA 32.2 19.5 13.5 5.8 3.1 28.9186053428365 -1.52534141542903 0.626983102642714 -2.43282699166814 0.0149814573440677 0.0553329738401333 Probable N-acetylglucosamine-6-phosphate deacetylase NagA (GlcNAc 6-P deacetylase) II.C.3 - Murein sacculus and peptidoglycan Rv3333c - 8 3.8 1.7 4.2 4.7 8.20249180366886 0.888708589879505 1.0697007926454 0.83080109502556 0.406086003963218 0.604543591096198 Hypothetical proline rich protein VI - Unknowns Rv3334 - 19.1 15.4 16.4 47.3 40.1 33.8577741888923 2.37555027612 0.617320370212208 3.84816440660041 0.000119006180380532 0.00104855694255682 Probable transcriptional regulatory protein (probably MerR-family) I.J.1 - Repressors/activators Rv3335c - 100 49.2 40.2 21.9 2.3 57.4573927149652 -1.67819165662501 0.528528134718895 -3.17521726164603 0.00149724352773732 0.00865128315700746 Probable conserved integral membrane protein V - Conserved hypotheticals Rv3336c trpS 323.7 214.1 156.2 65.1 25.2 269.227173963744 -1.58574962163158 0.299486382255419 -5.29489724938197 1.1908334969042e-07 2.33034930720148e-06 Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3337 - 64.6 41.1 22.8 40.8 12.8 25.3451438534604 0.124377315642324 0.611900061687528 0.203264100512281 0.838928613417211 0.91350881138875 hypothetical protein V - Conserved hypotheticals Rv3338 - 74.8 43.7 27.8 57.1 10.3 47.5123764009672 0.175016298131015 0.493734343441466 0.354474628827929 0.722983214533733 0.849919198764846 hypothetical protein V - Conserved hypotheticals Rv3339c icd1 438.4 332.1 223.2 171.1 57.7 537.043593625498 -0.772397440837667 0.263425520565632 -2.93212836470499 0.00336647568880777 0.0166336585505759 Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) I.B.3 - TCA cycle Rv3340 metC 45.2 23.5 23.4 52 20 91.4023993155253 1.01024067213506 0.37233042236958 2.71329069944298 0.00666186370977719 0.0292758328288223 Probable O-acetylhomoserine sulfhydrylase MetC (homocysteine synthase) (O-acetylhomoserine (thiol)-lyase) (OAH sulfhydrylase) (O-acetyl-L-homoserine sulfhydrylase) I.D.2 - Aspartate family Rv3341 metA 61.7 27.8 36.8 58.8 24 98.1022892970386 0.767841544008902 0.382952566718478 2.00505652851093 0.04495700413283 0.129672401171404 Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) I.D.2 - Aspartate family Rv3342 - 72.3 46.9 42.7 31.9 12.1 54.6980578707665 -0.568868102518233 0.456493302569894 -1.24616965750803 0.212702116033604 0.393575323989253 Possible methyltransferase (methylase) V - Conserved hypotheticals Rv3343c PPE54 17.4 21.2 14.5 3.1 2.1 160.17831688143 -2.04847005605107 0.433807348046178 -4.72207320894209 2.33452613644944e-06 3.56417740314823e-05 PPE family protein PPE54 IV.C.2 - PPE family Rv3344c PE_PGRS49 4.4 1.2 3.6 0.9 0 4.46085619069164 -1.89111629958902 1.50297758896064 -1.25824650578908 0.20830262080332 NA PE-PGRS family protein PE_PGRS49 IV.C.1.b - PE_PGRS subfamily Rv3345c PE_PGRS50 3.1 1.9 2.2 0.7 0.2 11.5297003149744 -1.94835052778595 0.993255206227115 -1.96158098701216 0.0498112876354424 0.139803154361915 PE-PGRS family protein PE_PGRS50 IV.C.1.b - PE_PGRS subfamily Rv3346c - 11.6 0 5.1 6.7 0 1.8152767031801 0.0307604556613872 2.12968759503437 0.0144436469147442 0.988476037812553 NA Conserved transmembrane protein V - Conserved hypotheticals Rv3347c PPE55 40.9 24.6 26.2 28.4 14 517.357445213602 0.331936378084901 0.289663433917997 1.14593814481559 0.251820746675524 0.444197751356925 PPE family protein PPE55 IV.C.2 - PPE family Rv3348 - 22 12.2 11.3 20.3 12.5 16.3714454435129 0.99816380686613 0.747185727834918 1.33589784933186 0.181582664015415 0.354204893095119 Probable transposase IV.B.1.c - Others Rv3349c - 1.7 4.7 0.3 2.3 0 1.99173775313922 0.0533759162474139 2.10649916509954 0.0253386837895526 0.979784818625542 NA Probable transposase IV.B.1.c - Others Rv3350c PPE56 8.7 5.7 4.3 2.4 1.4 91.2721598769636 -0.907378221712773 0.40998702932749 -2.21318762986518 0.0268847125766711 0.0873102560024061 PPE family protein PPE56 IV.C.2 - PPE family Rv3351c - 1.6 0 0 3.3 0 1.1257626601213 2.05256930865182 2.80006075524125 0.733044561554512 0.463531251082978 NA hypothetical protein V - Conserved hypotheticals Rv3352c - 2.4 5.9 0 0.9 0 1.00638646204462 -1.03304297647468 2.73783730502596 -0.377320805213036 0.705935212577832 NA Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3353c - 5.1 4.4 0 10.4 16.8 5.46231855257841 3.11665579549548 1.39440939376164 2.23510814645891 0.0254102496895 NA hypothetical protein V - Conserved hypotheticals Rv3354 - 6.4 4.4 8.8 20.9 10.1 9.02713348785065 2.11906581124299 1.01200788875265 2.09392222609533 0.0362669089905483 0.109980643531269 hypothetical protein V - Conserved hypotheticals Rv3355c - 30.9 23.8 11.2 21.9 6 9.1467106004046 0.0608597722658374 0.962090942525179 0.0632578164659778 0.94956120603677 0.977994521000095 Probable integral membrane protein V - Conserved hypotheticals Rv3356c folD 57.2 20.4 35.5 36.4 7 46.7783745376506 -0.104139180578841 0.518687076791549 -0.200774581127058 0.840874839521926 0.91350881138875 Probable bifunctional protein FolD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase I.G.2 - Folic acid Rv3357 relJ 3.7 3.5 0 14.9 0 1.56422755912263 2.88437104341041 2.45938990206021 1.17279941704005 0.240876251979938 NA Antitoxin RelJ V - Conserved hypotheticals Rv3358 relK 5 3 0.7 17 0 1.72370862976349 2.67730040976072 2.372743165803 1.1283565993771 0.259169349083907 NA Toxin RelK VI - Unknowns Rv3359 - 14.4 7.9 10.4 18.2 8 30.3679050472596 1.03624677147768 0.572530501662097 1.80994159869104 0.0703048442755332 0.179022112454305 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3360 - 43.7 18.9 26.3 36 5.8 15.9217631364619 0.0859712188719017 0.784330825974572 0.109610914202024 0.912717954536601 0.957880591101819 hypothetical protein II.C.5 - Other membrane proteins Rv3361c - 69.1 34.4 38.3 9.7 1 25.9308694547741 -2.46355783597101 0.743124768209295 -3.31513352987472 0.000915993580608272 0.0057322425132765 hypothetical protein V - Conserved hypotheticals Rv3362c - 96.3 75.9 54 29.8 5.4 50.134031761261 -1.41950783815577 0.515132364567 -2.75561765440412 0.00585814315146687 0.026198917982949 Probable ATP/GTP-binding protein VI - Unknowns Rv3363c - 84.6 63.6 52.8 26 0 26.9080818048647 -1.62505096708386 0.710463072153464 -2.28731236115934 0.0221775974972648 0.0752423853786514 hypothetical protein VI - Unknowns Rv3364c - 78.5 33 72.9 21.4 0 26.6697669983874 -1.84964129040424 0.76821957670864 -2.40769871854717 0.0160534228989084 0.0584520071112423 hypothetical protein VI - Unknowns Rv3365c - 105.9 62.7 61.5 39.7 16.8 275.846480394029 -0.649929785492869 0.297456946707386 -2.18495413432794 0.0288922096908369 0.0921947808332832 hypothetical protein V - Conserved hypotheticals Rv3366 spoU 15.4 8.2 6.9 7 6.5 7.78667923559482 0.120960494862707 1.05851306006216 0.114273974905519 0.909020612351718 0.955699319961349 Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3367 PE_PGRS51 24.4 8.3 5.5 14 4.5 35.2170071293571 0.344502953429124 0.568815747367887 0.60564946561916 0.54474754760843 0.722928367789082 PE-PGRS family protein PE_PGRS51 IV.C.1.b - PE_PGRS subfamily Rv3368c - 16.3 6.2 8.7 5.8 3.1 8.24429770789574 -0.598186901031765 1.03913762290716 -0.575657052391423 0.564847009911094 0.737716854389784 Possible oxidoreductase V - Conserved hypotheticals Rv3369 - 51.4 36.9 17.3 24.2 0.3 17.263314404768 -0.787194727696767 0.822325762312547 -0.957278445810836 0.338426731558155 0.53947231466201 hypothetical protein V - Conserved hypotheticals Rv3370c dnaE2 15.6 3.7 6.9 13.1 1.8 45.9996876198056 0.461051075738984 0.550023831806029 0.838238361827161 0.401896845896108 0.600387443342056 Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3371 - 201.1 60.8 125.4 426.3 111.6 524.805821628276 1.7434703148278 0.342777599438036 5.08630178193125 3.65112930276411e-07 6.53146464161136e-06 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3372 otsB2 34.6 17.7 17.8 29.7 4.9 42.7274671060571 0.20376832797744 0.516693651931283 0.394369714463881 0.693308100111259 0.830220960237125 Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP) III.E - Adaptations and atypical conditions Rv3373 echA18 20.4 10.8 6.5 12 3.6 12.017940436161 0.176510343031638 0.848577641160074 0.208007298884678 0.8352232683152 0.913074326040876 Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3374 echA18.1 18.1 28.2 1.3 11.1 7.9 5.43923945642629 0.0176008018090412 1.37579510914147 0.0127931853312261 0.989792793369569 NA Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3375 amiD 20.3 12.5 9.9 3.9 1.4 21.8191953106211 -1.81552472073937 0.707802050436907 -2.56501760572564 0.0103170569932489 0.0406937815925251 Probable amidase AmiD (acylamidase) (acylase) IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3376 - 534.7 348.4 269.5 201.1 72 332.680164666324 -0.725881666753343 0.274664022711584 -2.64279849827863 0.00822239527017096 0.0343440142063037 hypothetical protein V - Conserved hypotheticals Rv3377c - 74.8 47.7 31.9 50.2 30.8 148.033099527049 0.594381638548317 0.362833125633165 1.63816806282802 0.10138663988225 0.234990650958649 Halimadienyl diphosphate synthase IV.J - Cyclases Rv3378c - 37 23.8 14.9 29.3 4 33.2530998587439 0.123804749491304 0.566389310456137 0.218585957054167 0.826972592927083 0.907781430302224 Diterpene synthase VI - Unknowns Rv3379c dxs2 4.4 1.1 2 3.1 1.4 6.31942809083281 0.430830260450251 1.16191256475393 0.370794045541192 0.710790936699922 NA Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) IV.H - Miscellaneous transferases Rv3380c - 4 8.8 1.7 4.8 3.7 9.90751041074706 0.803392350724057 1.02427995212723 0.784348408904783 0.432835701722038 0.628063930970691 Probable transposase IV.B.1.a - IS6110 Rv3381c - 15.5 29 14.8 13.3 5.6 9.21160021414949 -0.519404425670922 1.02210818288948 -0.508169716636626 0.611334326522742 0.770037761217479 Probable transposase for insertion sequence element IS6110 (fragment) IV.B.1.a - IS6110 Rv3382c lytB1 33.7 36.5 15.6 18.3 6.8 39.5664567330966 -0.454436567089655 0.542860780321214 -0.837114382845564 0.402528276541078 0.600823917197007 Probable LYTB-related protein LytB1 II.C.3 - Murein sacculus and peptidoglycan Rv3383c idsB 49.6 57.9 23.6 16.7 5.8 56.4751568060073 -1.20020827171948 0.510230063983019 -2.3522884213256 0.0186583011417234 0.0660196215686878 Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3384c vapC46 60.8 31.9 16.5 41.7 10.9 22.1014228976486 0.273223539964882 0.659305962888308 0.414410843135614 0.678573249236331 0.820589432842296 Possible toxin VapC46 Contains PIN domain V - Conserved hypotheticals Rv3385c vapB46 109.5 81.2 45.9 56.1 29.8 37.6166432161782 -0.118738205993554 0.532627162712032 -0.222929310230749 0.823590524089573 0.906045859973057 Possible antitoxin VapB46 V - Conserved hypotheticals Rv3386 - 12.1 7.3 4.6 7.5 0.1 6.92974148200251 -0.409092058048746 1.15070184868641 -0.355515252292108 0.722203620588332 NA Possible transposase IV.B.1.c - Others Rv3387 - 6.9 3 3 2.8 5.8 7.09852980530203 0.838131358395653 1.18134722829978 0.709470795984268 0.478032368120588 NA Possible transposase IV.B.1.c - Others Rv3388 PE_PGRS52 7.7 7.8 3.8 0.8 0 13.9280682085637 -3.06946132811243 0.996961912711585 -3.07881503693954 0.00207825667144107 0.0113629217363719 PE-PGRS family protein PE_PGRS52 IV.C.1.b - PE_PGRS subfamily Rv3389c htdY 95.4 57.8 39.5 44.7 21.9 85.3880228645493 -0.101948202564238 0.397893228727128 -0.256219998742812 0.797780967166607 0.895015969542792 Probable 3-hydroxyacyl-thioester dehydratase HtdY I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3390 lpqD 98.3 108 63 73.5 53.2 122.119895218081 0.424523631501712 0.424169074929788 1.00083588501114 0.316906157525225 0.514899821079976 Probable conserved lipoprotein LpqD II.C.1 - Lipoproteins(lppA-lpr0) Rv3391 acrA1 37.4 29.2 16.5 22 5.5 77.2418276401174 -0.270238920678237 0.411135727102064 -0.657298558271854 0.510988963340555 0.69558912688403 Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 I.H.2 - Modification of fatty and mycolic acids Rv3392c cmaA1 49.3 21.7 23.3 23.5 11.6 42.2408229311311 -0.0539765355054817 0.50713126597277 -0.106435037883032 0.915237194742759 0.958536411525385 Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic acid synthase 1) I.H.2 - Modification of fatty and mycolic acids Rv3393 iunH 28.9 13 9.8 14 0 18.4225154252756 -0.576512610175583 0.797730449138863 -0.722690992675432 0.469869750631624 0.660952603946471 Probable nucleoside hydrolase IunH (purine nucleosidase) I.F.4 - Salvage of nucleosides and nucleotides Rv3394c - 13 9.3 5.4 5.3 2.5 20.1779910187246 -0.49337151914941 0.687883186964839 -0.717231542358701 0.47323123968322 0.663310269472879 hypothetical protein VI - Unknowns Rv3395c - 36.7 36.4 31.8 9.5 6.4 27.192819319458 -1.54083553961052 0.676572505528711 -2.27741376869346 0.0227615286591172 0.076928754304001 hypothetical protein VI - Unknowns Rv3395A - 4.7 0.5 4.3 4.4 0 2.70774888742869 0.0994971010228832 1.8405340390625 0.0540588214676885 0.956888299954841 NA Probable membrane protein ? Rv3396c guaA 65.4 30 23.9 52.8 3.8 91.220582897715 0.104700317798954 0.47083625889607 0.222370974666302 0.824025105044006 0.906099295316329 Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase) I.F.1 - Purine ribonucleotide biosynthesis Rv3397c phyA 17.9 16 6.5 9.4 0 14.2365748183171 -0.827399819209719 0.887626491273617 -0.932148631596742 0.351259718252117 0.552178724927541 Probable phytoene synthase PhyA I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3398c idsA1 11.5 6.1 5.8 2.5 0 8.43991233115445 -1.74369746066893 1.11403821023135 -1.56520435713495 0.117535000215224 0.262660328939583 Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate synthase): dimethylallyltransferase (prenyltransferase) (geranyl-diphosphate synthase) + geranyltranstransferase (farnesyl-diphosphate synthase) (farnesyl-pyrophosphate synthetase) (farnesyl diphosphate synthetase) (FPP synthetase) + farnesyltranstransferase (geranylgeranyl-diphosphate synthase) I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3399 - 21.1 15.8 6.3 10 3.8 21.0672306176269 -0.301771166688574 0.684310841870833 -0.440985511589388 0.659223485922892 0.808783992197238 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv3400 - 91.3 37.1 54.6 58.7 0 61.4004611893077 -0.825268092859065 1.47345195773976 -0.560091619223884 0.575416946600337 0.745201764116414 Probable hydrolase I.C.3 - Sugar nucleotides Rv3401 - 104.8 72.1 74.3 39.6 12.1 256.510170260198 -0.997475273025359 0.313069037017677 -3.1861192104061 0.00144195168337566 0.00840031720808648 hypothetical protein V - Conserved hypotheticals Rv3402c - 11.3 8.8 12.2 15.5 4 25.2027770370957 0.514618537459426 0.641001621570004 0.80283500094582 0.422070108957989 0.616992292995954 hypothetical protein II.C.5 - Other membrane proteins Rv3403c - 33.7 17 17.8 21 6.3 56.0554474776147 -0.0153481134614225 0.445427965055525 -0.0344570046461031 0.972512727294164 0.989545807379404 Hypothetical protein VI - Unknowns Rv3404c - 61.3 58.8 25.6 47.4 8 49.0886835716442 -0.160802018051583 0.518511144489693 -0.310122588030082 0.756467735727877 0.873340521495482 hypothetical protein VI - Unknowns Rv3405c - 16.9 12.2 10.4 21.9 11.8 17.6159168128089 1.14073983306097 0.713120231014194 1.59964587098955 0.109677166228986 0.248704560040376 Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3406 - 6.3 4.7 3.8 4.9 2.7 8.15682751406841 0.399529002333554 1.01716363203748 0.392787344877105 0.694476552340101 0.830500653218631 Probable dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3407 vapB47 5708.3 3730.2 2707.7 4266.5 1170 1965.58514926872 0.136932060617924 0.228525982061723 0.599196902612761 0.549041588030206 0.726392246777547 Possible antitoxin VapB47 V - Conserved hypotheticals Rv3408 vapC47 2304.5 1538.5 1439.7 1180.8 637.3 1151.88050931713 -0.0501699097204687 0.280818602317013 -0.178655934138696 0.858207871863019 0.923101209273858 Possible toxin VapC47 Contains PIN domain V - Conserved hypotheticals Rv3409c choD 91 38.2 34.2 76.4 20.3 168.182891954502 0.585488828545756 0.329295382053923 1.7780049780652 0.0754030372997481 0.188348066372149 Cholesterol oxidase ChoD (cholesterol-O2 oxidoreductase) I.A.3 - Fatty acids Rv3410c guaB3 62.8 29.3 32.6 48.5 12.7 77.8109861718751 0.294289001863619 0.401528491414319 0.732921842798835 0.463606100001171 0.656310485457048 Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv3411c guaB2 212.2 142.2 134.6 180.3 82.6 493.246209518725 0.525555935420909 0.279800067137824 1.87832669518993 0.06033648680722 0.160685591181333 Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase) (imp oxidoreductase) (inosine-5'-monophosphate oxidoreductase) (IMPDH) (IMPD) I.F.1 - Purine ribonucleotide biosynthesis Rv3412 - 912.4 498.7 466.7 1129.7 399 580.987833489673 1.07825287290917 0.248123804250441 4.34562446020234 1.38879998222682e-05 0.000171997536260398 hypothetical protein V - Conserved hypotheticals Rv3413c - 107.5 59.1 37.7 118.3 27.4 117.856434393197 0.828911367497696 0.361421640409964 2.29347464240784 0.0218206936217109 0.074387773636285 Unknown alanine and proline rich protein VI - Unknowns Rv3414c sigD 259 96.9 80.4 257.4 63.3 181.767700400134 0.921319426763497 0.344010210994485 2.67817465097938 0.00740246084833675 0.0318584645501929 Probable alternative RNA polymerase sigma-D factor SigD II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3415c - 6 6.8 4.2 3.3 7.3 11.772003740492 0.991726868354387 0.983895457992534 1.00795959601016 0.313473859370442 0.511199083743142 hypothetical protein V - Conserved hypotheticals Rv3416 whiB3 348.6 156.4 202.8 499.2 190.8 185.439436886394 1.33554762410149 0.32416601364017 4.11994955641455 3.78955354860059e-05 0.000401874211650997 Transcriptional regulatory protein WhiB-like WhiB3 Contains [4FE-4S] cluster I.J.1 - Repressors/activators Rv3417c groEL1 106 74.4 46.3 241.8 74.8 382.305500909642 1.83304610688923 0.268416558800922 6.82910963123089 8.54432619285961e-12 3.83088650317832e-10 60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1) III.B - Chaperones/Heat shock Rv3418c groES 829.4 620.2 729.8 2042.7 1375.3 891.513675195186 2.18294846112143 0.342702132000114 6.36981289956113 1.89258934385173e-10 6.64403242172427e-09 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen) III.B - Chaperones/Heat shock Rv3419c gcp 134.2 78.1 59.9 24.1 12.8 109.625443129262 -1.50508539364649 0.390837573260311 -3.8509229834053 0.000117673503149756 0.00103940036946742 Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease) II.B.3 - Proteins, peptides and glycopeptides Rv3420c rimI 299 248 183.3 195.1 146 219.591581392635 0.448263674721715 0.369211020364707 1.21411239100859 0.22470480894329 0.408585427954563 Ribosomal-protein-alanine acetyltransferase RimI (acetylating enzyme for N-terminal of ribosomal protein S18) II.A.1 - Ribosomal protein synthesis and modification Rv3421c - 65.8 15 16.3 16.8 3.1 21.946625500795 -0.971968934010085 0.745823061977128 -1.30321651818256 0.19250085234338 0.36816307721396 hypothetical protein V - Conserved hypotheticals Rv3422c - 106.7 62.6 81 27.3 0.3 45.7608771091021 -1.93292037750246 0.62502896170294 -3.09252930014006 0.00198458641178655 0.0110006339132206 hypothetical protein V - Conserved hypotheticals Rv3423c alr 112.7 79.9 47.7 46.4 9.8 123.836260311109 -0.784356520169807 0.367894373848994 -2.13201553468647 0.0330055695044767 0.101834257129666 Alanine racemase Alr I.D.6 - Pyruvate family Rv3424c - 82.7 42.6 28.8 54.9 5.6 24.49559310821 -0.105964919681001 0.675859725971571 -0.156785373664147 0.875414000408201 0.93588751858224 Hypothetical protein VI - Unknowns Rv3425 PPE57 78.3 37.6 37.3 92.5 27.1 57.2686312802668 0.987976508670413 0.435245204827687 2.2699308291324 0.0232117802408933 0.0780779920353697 PPE family protein PPE57 IV.C.2 - PPE family Rv3426 PPE58 32.6 30.1 9.5 14.6 8.5 25.2109509507424 -0.196457321205897 0.667035695775289 -0.294522950496011 0.768358328750271 0.878478115052763 PPE family protein PPE58 IV.C.2 - PPE family Rv3427c - 48 32.3 39.5 5.9 10.3 38.9324553847611 -1.63692630651015 0.676980189758143 -2.41798258098949 0.0156068239050168 0.0571067874706297 Possible transposase IV.B.1.c - Others Rv3428c - 3.3 1.3 2.1 0 0 2.41375285576876 -3.6135669852668 2.07003888317121 -1.74565174337738 0.0808714851803111 NA Possible transposase IV.B.1.c - Others Rv3429 PPE59 829 705.2 342.2 380 164.1 481.602523979357 -0.353865296594083 0.303176805430585 -1.16719119093398 0.243133167557711 0.431451743231169 PPE family protein PPE59 IV.C.2 - PPE family Rv3430c - 22.4 5 17.6 11.7 2 22.3599684484764 -0.600508545497236 0.767177848253214 -0.782750110505058 0.433773869430984 0.628909965421427 Possible transposase IV.B.1.c - Others Rv3431c - 29.7 9.2 10.7 14.9 0 16.4097425011863 -0.45876940517034 0.843318720835866 -0.544004768109054 0.586438191713532 0.75450928988352 Possible transposase (fragment) IV.B.1.c - Others Rv3432c gadB 25.5 18.5 10.5 8.7 8.3 38.7037500602615 -0.227474866835827 0.576363122636173 -0.394672833673677 0.693084354154625 0.830220960237125 Probable glutamate decarboxylase GadB I.C.1 - General Rv3433c - 25.6 9.8 15.1 9.8 0.2 26.9676398842356 -1.12634396924924 0.720296102925022 -1.56372353630029 0.117882507938616 0.263100090181839 hypothetical protein V - Conserved hypotheticals Rv3434c - 37.4 30.3 21.8 46.3 9.5 38.1081888360895 0.577689879956868 0.524838067326313 1.10070117988925 0.27102673257527 0.466687742723192 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3435c - 58.9 41.1 23 61 13 61.9894269865683 0.571741945136145 0.440658121740016 1.29747284102815 0.194468543942549 0.370907260563207 Probable conserved transmembrane protein V - Conserved hypotheticals Rv3436c glmS 38.6 24.1 15.9 46 8.9 93.0597429642195 0.77026500591125 0.386369498375322 1.9935968267428 0.0461961324387637 0.132277042116492 Probable glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS (hexosephosphate aminotransferase) (D-fructose-6-phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (glucosamine-6-phosphate synthase) I.C.4 - Amino sugars Rv3437 - 44.5 38 21.5 36.6 8.3 25.1597094326777 0.114973309681945 0.620065564875005 0.185421213811675 0.852898670697831 0.919904717299549 Possible conserved transmembrane protein VI - Unknowns Rv3438 - 25.3 17.6 5.7 18.5 1.7 18.4921857671902 0.0353568222582228 0.767661483328716 0.0460578302104065 0.963264156932549 0.984610856411041 hypothetical protein V - Conserved hypotheticals Rv3439c - 27.7 21.1 18.3 6.8 4 38.5656162080845 -1.39869288161806 0.558072291639918 -2.50629336480395 0.0122004346294724 0.0469716733234686 Conserved hypothetical alanine and proline rich protein V - Conserved hypotheticals Rv3440c - 60 41.2 33.3 41.5 1 17.5585775524384 -0.483681442809259 0.801750069387464 -0.603282071654563 0.54632105765693 0.724202539753311 Hypothetical protein VI - Unknowns Rv3441c mrsA 171.4 109.9 82.1 87.7 28.7 234.91900368007 -0.29845729870914 0.289992987832175 -1.02918798464832 0.303391347344145 0.499819605717656 Probable phospho-sugar mutase / MrsA protein homolog I.A.1 - Carbon compounds Rv3442c rpsI 141.8 68 56.1 210.9 36.5 88.0061055423949 1.16375898665197 0.403453163408371 2.88449587758969 0.00392040891449201 0.0188158379066812 30S ribosomal protein S9 RpsI II.A.1 - Ribosomal protein synthesis and modification Rv3443c rplM 264.2 142.5 136.4 128.7 59.4 123.430830268672 -0.133981259094962 0.353917156828735 -0.378566725319273 0.70500963548774 0.838305512053535 50S ribosomal protein L13 RplM II.A.1 - Ribosomal protein synthesis and modification Rv3444c esxT 5.7 0 3.2 6.7 0 1.34140566777372 0.980514994288401 2.40337086948992 0.407974901724801 0.683292101237132 NA Putative ESAT-6 like protein EsxT V - Conserved hypotheticals Rv3445c esxU 7.2 0 10.2 2.3 6.2 3.48103806557573 -0.322320376507821 1.69041070762129 -0.190675777818151 0.848779616996935 NA ESAT-6 like protein EsxU VI - Unknowns Rv3446c - 1.2 1.4 1.4 0 0 1.27048234006567 -2.55866150767145 2.5183687220465 -1.01599955767883 0.309629597182303 NA Hypothetical alanine and valine rich protein VI - Unknowns Rv3447c eccC4 2.2 1.9 0.6 0.3 0.5 6.49448241214305 -1.64328747345702 1.27407424718797 -1.28978941147578 0.197123785313346 NA ESX conserved component EccC4 ESX-4 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv3448 eccD4 0.7 1.2 1.5 0 0 1.43478639982567 -2.71011603137551 2.44729115333367 -1.10739420100621 0.268123532032777 NA ESX conserved component EccD4 ESX-4 type VII secretion system protein Probable integral membrane protein II.C.5 - Other membrane proteins Rv3449 mycP4 2.1 1.3 0.6 0.6 0 1.5105612743934 -0.803728626486803 2.17185318314426 -0.370065818778422 0.711333449645523 NA Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3450c eccB4 8 8.9 2.7 3.5 0.8 11.6354465888791 -0.80305989925304 0.91669685322623 -0.876036496063824 0.381010193599545 0.581446835730111 ESX conserved component EccB4 ESX-4 type VII secretion system protein Probable membrane protein II.C.5 - Other membrane proteins Rv3451 cut3 42.4 16 15.8 55.6 27.5 55.6924766899117 1.62151744185046 0.467515281730212 3.46837313178178 0.000523619699381505 0.00361376285006291 Probable cutinase precursor Cut3 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3452 cut4 61.1 40.9 29.4 24.6 13.7 42.4376112818637 -0.447528975259793 0.509068650117368 -0.879113210284337 0.379339895753844 0.579531154283012 Probable cutinase precursor Cut4 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3453 - 7.3 4.8 5.3 10.9 3.3 2.66386819357625 0.71572815228221 1.71872672108655 0.41642929239486 0.677095897505784 NA Possible conserved transmembrane protein VI - Unknowns Rv3454 - 4.8 4.1 1.7 5.3 3.1 10.2007386449196 1.0918727387746 0.924209782324615 1.18141222875641 0.23743900240598 0.423895638367934 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3455c truA 162.1 76.8 58.9 37.3 0.3 78.3422571602276 -2.01705056474552 1.16765112668928 -1.7274428282912 0.0840881645266954 0.206095433749154 Probable tRNA pseudouridine synthase a TruA (pseudouridylate synthase I) (pseudouridine synthase I) (uracil hydrolyase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3456c rplQ 735.7 405.2 310.7 284 81.9 342.308158131406 -0.641952640141148 0.275094457396397 -2.33357169830626 0.0196181599733642 0.0685281288221459 50S ribosomal protein L17 RplQ II.A.1 - Ribosomal protein synthesis and modification Rv3457c rpoA 406 198.1 210.7 278.2 87.5 464.708179157116 0.190690372423633 0.264946952493758 0.719730386135036 0.471691013606185 0.662119461726352 Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3458c rpsD 533.3 241.6 254.5 565 184.7 432.066580137997 0.911031432763074 0.267749184815842 3.40255539298721 0.000667588208529438 0.00442808508354171 30S ribosomal protein S4 RpsD II.A.1 - Ribosomal protein synthesis and modification Rv3459c rpsK 571.1 280.6 372.2 693 356 428.212936644689 1.2477713168536 0.313290728083024 3.98279044033161 6.81108096478766e-05 0.000648517440249406 30S ribosomal protein S11 RpsK II.A.1 - Ribosomal protein synthesis and modification Rv3460c rpsM 672.2 345.9 502.7 1003.5 538.4 536.405619186832 1.48750428837607 0.324745270912527 4.58052640519202 4.63807051413693e-06 6.51906577820357e-05 30S ribosomal protein S13 RpsM II.A.1 - Ribosomal protein synthesis and modification Rv3461c rpmJ 1879.4 1465.3 1343.6 2900.7 3920 777.443422732077 2.3662026763295 0.745832067631711 3.17256763153542 0.0015109736208116 0.00870222530880438 50S ribosomal protein L36 RpmJ II.A.1 - Ribosomal protein synthesis and modification Rv3462c infA 2110 1909.2 1903.4 2486 3003.3 1362.87859768087 1.63826609748457 0.703051529203459 2.33022193883952 0.0197944240237814 0.0688045631915934 Probable translation initiation factor if-1 InfA II.A.6 - Protein translation and modification Rv3463 - 10.7 12.5 6.9 8.1 0 10.6724682583683 -0.629753627664653 0.984598205763944 -0.639604687453225 0.522429634275527 0.704395037915461 hypothetical protein II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3464 rmlB 346.1 262 242.5 135.9 55.5 383.063880428041 -0.816586934898246 0.294770347277829 -2.77024789786128 0.00560136430839759 0.0252739265991647 dTDP-glucose 4,6-dehydratase RmlB I.C.3 - Sugar nucleotides Rv3465 rmlC 221.3 163.5 100.4 92.8 21.8 126.201698679687 -0.769348932294746 0.361079367656988 -2.13069203396191 0.0331145217855517 0.101856570706718 dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimerase) (dTDP-L-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase) I.C.3 - Sugar nucleotides Rv3466 - 80.2 42.7 39.4 32 15.1 50.9087860727401 -0.425275226026252 0.470919934378987 -0.903073314547773 0.366486985760368 0.567350045263647 hypothetical protein IV.B.2 - REP13E12 family Rv3467 - 12.7 4.5 13.6 2.5 1 10.6119672910821 -2.37336123147907 1.11577203321493 -2.1271022761169 0.0334115862068769 0.102639929180189 hypothetical protein IV.B.2 - REP13E12 family Rv3468c - 7 6.6 1 5.5 1.9 7.87806947671479 0.277064121874146 1.10339850417453 0.251100686493519 0.801736265161116 0.896385685353748 Possible dTDP-glucose 4,6-dehydratase I.C.3 - Sugar nucleotides Rv3469c mhpE 15.4 11.6 5.3 5.5 1.8 12.9210939429447 -0.897282176766145 0.857388961506737 -1.04652872505998 0.295316989826377 0.491085811251187 Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA) II.B.6 - Aromatic hydrocarbons Rv3470c ilvB2 9 10.6 3.2 5.7 1.2 16.4088691943218 -0.514010927442078 0.805674647028553 -0.637988211913862 0.523481353642254 0.70527613335902 Probable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS) I.D.7 - Branched amino acid family Rv3471c - 0.9 0 0 0 0 0.0987469571131013 0.126759651879696 4.45882529160685 0.0284289344366787 0.977320047179988 NA hypothetical protein V - Conserved hypotheticals Rv3472 - 17.3 9.7 8.5 9.9 5.3 9.39205652842958 0.176467919915175 0.949662753743688 0.185821671134849 0.852584609399989 0.919904717299549 hypothetical protein I.H.1 - Synthesis of fatty and mycolic acids Rv3473c bpoA 0.8 1.1 0 0.5 0 0.208854549197404 0.856351915824248 4.42645697911262 0.19346215717563 0.846597040357858 NA Possible peroxidase BpoA (non-haem peroxidase) III.F - Detoxification Rv3474 - 11 3.3 11.6 11.5 15.1 9.02877747096017 1.59296032645333 1.05824130340197 1.50529025972845 0.132249468281161 0.284758429575607 Possible transposase for insertion element IS6110 (fragment) IV.B.1.a - IS6110 Rv3475 - 4.7 7.3 3 5.1 1 6.46539217187441 -0.306831286656525 1.21694987559322 -0.252131408869207 0.800939493245496 NA Possible transposase for insertion element IS6110 [second part] IV.B.1.a - IS6110 Rv3476c kgtP 12.4 11.3 2.7 14.2 1.5 18.2105534758469 0.495750470030858 0.792914211953297 0.625225859944679 0.531822831724502 0.711987589353515 Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) III.A.3 - Carbohydrates, organic acids and alcohols Rv3477 PE31 844.4 651.6 468.1 1513.3 482.5 499.362072442922 1.34627523167791 0.259459056605882 5.18877717852377 2.11679502528564e-07 4.00945881259986e-06 PE family protein PE31 IV.C.1.a - PE subfamily Rv3478 PPE60 995.9 762.9 468.2 695.9 220.5 1398.18918123289 0.0547483063317047 0.243802583617263 0.22455999243081 0.822321591378064 0.906045859973057 PE family protein PPE60 IV.C.2 - PPE family Rv3479 - 104.6 89.6 48.3 35.8 6.1 291.988620650017 -1.32144740504651 0.345281315190329 -3.82716164156781 0.000129629394035022 0.0011281260778183 Possible transmembrane protein VI - Unknowns Rv3480c - 62.7 30.2 20.7 181.6 19.9 176.996301313547 1.97669622073583 0.404920485785893 4.8816898381897 1.05180599489403e-06 1.71281816896162e-05 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3481c - 12.2 2.6 3.9 9.1 2.9 6.75503547005087 0.623895557495253 1.13877996106572 0.547863133200365 0.583785884746245 NA Probable integral membrane protein II.C.5 - Other membrane proteins Rv3482c - 38.8 21.5 20.5 14 19.4 38.9627513610627 0.254670799084378 0.611989794665065 0.416135695896296 0.677310710844222 0.820502818639317 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv3483c - 58.8 41.6 28.7 37.4 5.4 38.9438211454185 -0.285765397438968 0.534819585614283 -0.534321115242523 0.593119385816281 0.759028225843 Possible exported protein V - Conserved hypotheticals Rv3484 cpsA 139.7 97.7 85.1 47.5 32.6 238.649396043568 -0.516563266940405 0.35229372269649 -1.46628575436025 0.14257045477434 0.300586042149234 Possible conserved protein CpsA V - Conserved hypotheticals Rv3485c - 102.7 159.9 55 15.4 8.8 112.605861526152 -2.39807193866822 0.510369144464912 -4.69870086128039 2.61821610771254e-06 3.96312882628966e-05 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3486 - 16.9 10.6 16.5 16.8 19.3 17.8998461486402 1.22758295464278 0.792831560669927 1.54835278455048 0.121537382330001 0.268215207609261 hypothetical protein V - Conserved hypotheticals Rv3487c lipF 800.8 730.9 440.6 455.3 103.9 755.296655714364 -0.604676108029116 0.286162884129991 -2.11304869206741 0.0345966004956889 0.105457107535052 Probable esterase/lipase LipF II.B.5 - Esterases and lipases Rv3488 - 23.5 33.4 0 16.9 0 7.24937572555211 -0.449957882269124 1.33782975470241 -0.336334186534231 0.736618872842877 0.859388684983357 hypothetical protein V - Conserved hypotheticals Rv3489 - 3351.8 2454.7 1518.3 2055.3 678.7 617.108802274223 -0.0675933508155367 0.257391789146693 -0.262608807528875 0.792852110846549 0.892935509258657 hypothetical protein VI - Unknowns Rv3490 otsA 573.4 411.7 246.2 248.7 75.2 827.855817191066 -0.5905304456045 0.255114255195884 -2.31476851480163 0.0206256038818179 0.07120457012612 Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase) III.E - Adaptations and atypical conditions Rv3491 - 479.2 344.4 220.7 429.6 172.6 383.85765720511 0.61857403612868 0.274543326320732 2.25310170317539 0.0242527371158453 0.0806602768679098 hypothetical protein VI - Unknowns Rv3492c - 152.6 118.4 104.9 36 12 70.1010768520226 -1.72828882108429 0.454189078195975 -3.80521880435568 0.000141678890432493 0.00120922079496841 Conserved hypothetical Mce associated protein V - Conserved hypotheticals Rv3493c - 107.6 44.1 61.1 25.3 8.3 61.1797274976408 -1.33681213990818 0.472256859675911 -2.83068866554015 0.00464479085993159 0.0215620566525264 Conserved hypothetical Mce associated alanine and valine rich protein VI - Unknowns Rv3494c mce4F 97.5 42 55.2 18.9 9.3 130.723659656275 -1.41772133279161 0.388571538558196 -3.64854651488913 0.000263728157991796 0.0020758336346821 Mce-family protein Mce4F IV.A - Virulence Rv3495c lprN 119.8 83.5 50 39.8 16.6 126.906986442486 -0.774166074478599 0.359142755603557 -2.15559429335439 0.031115358552536 0.0976178919336426 Possible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E) II.C.1 - Lipoproteins(lppA-lpr0) Rv3496c mce4D 127.9 69.2 69.5 40.1 25.1 168.152475396259 -0.580755284566481 0.359361393568211 -1.61607589173668 0.106077905882777 0.242875205324367 Mce-family protein Mce4D IV.A - Virulence Rv3497c mce4C 95.6 49.8 54.8 42.4 15 100.045661391023 -0.474839991666777 0.37524582845906 -1.26541044737712 0.205724232043334 0.385950863293162 Mce-family protein Mce4C IV.A - Virulence Rv3498c mce4B 77 38.3 27.8 33.8 7.7 64.7568692499608 -0.459529953624946 0.443828149357053 -1.03537811716233 0.300492361120761 0.496805773865977 Mce-family protein Mce4B IV.A - Virulence Rv3499c mce4A 65.7 31.6 33.1 38 25.7 97.6028682416414 0.489497997881364 0.412267695729393 1.1873304722926 0.235097292967242 0.420775448049506 Mce-family protein Mce4A IV.A - Virulence Rv3500c yrbE4B 24.5 10.6 12.1 17.8 8 23.4247448748668 0.483459924836706 0.630641686063736 0.766615870026463 0.443309936981246 0.637782814442989 Conserved integral membrane protein YrbE4B Possible ABC transporter IV.A - Virulence Rv3501c yrbE4A 18.4 11.5 10.5 30.1 6.4 22.6562369300363 1.17141170940292 0.633703334298424 1.84851750969528 0.0645275137436157 0.16830372141376 Conserved integral membrane protein YrbE4A Possible ABC transporter IV.A - Virulence Rv3502c - 32.6 9.6 13.3 58.7 13.4 47.6099654101059 1.68181748982555 0.505489751646826 3.32710501913519 0.000877532950299247 0.00552082008873878 Probable short-chain type dehydrogenase/reductase Possible 17-beta-hydroxysteroid dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3503c fdxD 116.8 27.1 31 167 36.2 26.9258414721185 1.49601295347102 0.6416547113796 2.33149219812397 0.0197274209880266 0.0688045631915934 Probable ferredoxin FdxD I.B.6.c - Electron transport Rv3504 fadE26 15 4.2 6.2 20.4 2.8 19.6640394152089 1.09347041407135 0.734265523723269 1.489202990938 0.136433923453092 0.290588669194739 Probable acyl-CoA dehydrogenase FadE26 I.A.3 - Fatty acids Rv3505 fadE27 15.2 3.1 8.9 13.5 5.3 20.8497939850414 0.852004196661354 0.702259106913536 1.21323338960452 0.225040601713808 0.408938184279759 Probable acyl-CoA dehydrogenase FadE27 I.A.3 - Fatty acids Rv3506 fadD17 9 0.6 4.6 11 2.6 15.3906657568598 1.27126166508057 0.874586078103047 1.45355808525778 0.146068864743807 0.305217169995245 Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) I.A.3 - Fatty acids Rv3507 PE_PGRS53 17.5 7 9.6 14.2 2.9 77.0774512502507 0.275806480782079 0.423372417654199 0.651451226582625 0.514755251783108 0.698835991497037 PE-PGRS family protein PE_PGRS53 IV.C.1.b - PE_PGRS subfamily Rv3508 PE_PGRS54 40.4 16.4 17.1 11.1 3.5 170.683705575898 -0.957279376220698 0.338615170850434 -2.82704219606135 0.00469801368923473 0.0217012918068902 PE-PGRS family protein PE_PGRS54 IV.C.1.b - PE_PGRS subfamily Rv3509c ilvX 38.3 25.8 18.9 24.4 5.5 62.127528403178 -0.15926667071462 0.43395242108087 -0.367014130991425 0.713608477431244 0.845351580957012 Probable acetohydroxyacid synthase IlvX (acetolactate synthase) I.D.7 - Branched amino acid family Rv3510c - 23 24.6 9.2 14.5 8.7 26.6227770915567 0.14786214327152 0.638203991552003 0.231684767298218 0.816782863439996 0.903511837071975 hypothetical protein V - Conserved hypotheticals Rv3511 PE_PGRS55 12.7 6.6 10.4 7.9 2.8 32.8526692887796 -0.162642480059651 0.575751419381381 -0.28248732801111 0.777569861872215 0.882503669048917 PE-PGRS family protein PE_PGRS55 IV.C.1.b - PE_PGRS subfamily Rv3512 PE_PGRS56 8.8 5.3 5.2 1 0 20.3260729527944 -2.88382774200474 0.833797945738681 -3.45866496402782 0.000542859721161019 0.00371916660029464 PE-PGRS family protein PE_PGRS56 IV.C.1.b - PE_PGRS subfamily Rv3513c fadD18 8.3 9.2 4.9 7.4 0 6.17777866868305 -0.24446527031246 1.2085088893248 -0.202286696003572 0.839692600037197 NA Probable fatty-acid-CoA ligase FadD18 (fragment) (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3514 PE_PGRS57 29.8 8.9 12.4 10.4 1.9 92.9228739408891 -0.731852596970175 0.439281509343336 -1.6660218593407 0.095709060670911 0.226707605941319 PE-PGRS family protein PE_PGRS57 IV.C.1.b - PE_PGRS subfamily Rv3515c fadD19 7.3 5.3 4.1 18.2 4.8 26.6375746102422 1.77259366386742 0.593395345608107 2.98720520305207 0.0028154067692808 0.0145579135427629 Fatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3516 echA19 34 17.9 22.8 22.4 14.6 36.5025395950738 0.346515928517753 0.554302510868504 0.625138659348336 0.531880056868831 0.711987589353515 Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3517 - 4.7 2.1 1.3 1.5 0 1.92827037278821 -0.592048434133109 1.99256348035646 -0.297129019963365 0.766368009571109 NA hypothetical protein V - Conserved hypotheticals Rv3518c cyp142 66.6 40.9 23.9 48.6 8.2 77.9830259166031 0.0793477617135857 0.425928756683959 0.186293506762358 0.852214599188703 0.919904717299549 Probable cytochrome P450 monooxygenase 142 Cyp142 IV.F - Cytochrome P450 enzymes Rv3519 - 339.2 221.3 158.2 250.9 83.6 285.732022016 0.258096539942754 0.276571199137791 0.933201073529596 0.350716160563141 0.551859902583139 hypothetical protein VI - Unknowns Rv3520c - 211.1 125.4 98.2 107.6 33.1 216.993888464137 -0.27857195130468 0.294456393509677 -0.946055026974736 0.344120520528704 0.54487031010848 Possible coenzyme F420-dependent oxidoreductase IV.G - Coenzyme F420-dependent enzymes Rv3521 - 23.7 10.3 10.5 18.9 5.3 23.185015984506 0.481366050842307 0.628210652768195 0.766249424012756 0.44352790543658 0.637830223733807 hypothetical protein V - Conserved hypotheticals Rv3522 ltp4 14.2 11.3 7.3 10.9 3.6 18.6935232122583 0.165158299393042 0.690553691372938 0.239167933581934 0.810975366477801 0.900180115344522 Possible lipid transfer protein or keto acyl-CoA thiolase Ltp4 I.J.1 - Repressors/activators Rv3523 ltp3 348.7 170.7 129.5 113.7 36.6 323.8548071011 -0.721051383224712 0.286477530962597 -2.51695614941213 0.0118373560738716 0.0457229173540382 Probable lipid carrier protein or keto acyl-CoA thiolase Ltp3 I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3524 - 102.8 80.5 51.8 22.7 2.5 87.343489862839 -1.92374258930235 0.459614909572098 -4.18555305591231 2.84472610060499e-05 0.000314875620260714 Probable conserved membrane protein II.C.5 - Other membrane proteins Rv3525c - 10.9 9.2 6.3 6.7 3.8 6.63289975409335 -0.153221654630323 1.11657640655964 -0.137224513907135 0.890853334901957 NA Possible siderophore-binding protein I.G.14 - Iron utilisation Rv3526 kshA 92.8 65.8 60.1 182.8 46.6 213.780025418671 1.32324591384064 0.30804400026454 4.29563930056832 1.74190613968545e-05 0.00020853145205658 Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3527 - 67 30.8 51.1 85.8 62.8 64.5369455088527 1.47816598020733 0.487094484659928 3.03465965384382 0.00240807264008327 0.0129626037859802 Hypothetical protein VI - Unknowns Rv3528c - 41.5 36.7 37.2 114 82.1 119.203375397163 2.29160462012279 0.429470194017633 5.33588745399339 9.50783656756597e-08 1.89195264732127e-06 hypothetical protein VI - Unknowns Rv3529c - 15.3 9.9 10 17 4.3 25.0742980967228 0.554473575182138 0.60958138537904 0.909597288370878 0.363034929179927 0.564225414284906 hypothetical protein V - Conserved hypotheticals Rv3530c - 16.6 19.9 13.4 27 8.8 26.8125469395418 0.775520046852599 0.61551546622202 1.25995216921627 0.207686617350742 0.388493701907954 Possible oxidoreductase II.B.6 - Aromatic hydrocarbons Rv3531c - 18.8 9.7 7.3 30 7.8 32.5952332848293 1.42864071327869 0.547209982704108 2.61077238799424 0.0090337997552389 0.0365270761792879 Hypothetical protein VI - Unknowns Rv3532 PPE61 6.4 6.7 5 3.1 1.6 9.46055732922813 -0.793575486289755 0.980939774118354 -0.808995115936656 0.418517955607584 0.614080612577491 PPE family protein PPE61 IV.C.2 - PPE family Rv3533c PPE62 15.4 12.6 20.1 17.5 9.6 57.8553123029837 0.496954904886467 0.523840157993426 0.948676609273441 0.34278511409851 0.54487031010848 PPE family protein PPE62 IV.C.2 - PPE family Rv3534c hsaF 28.6 13.8 13.7 66.8 17.8 61.2319272407334 1.90782089686387 0.432712268869357 4.40898267536729 1.03857332052228e-05 0.000134256448952186 Probable 4-hydroxy-2-oxovalerate aldolase (HOA) II.B.6 - Aromatic hydrocarbons Rv3535c hsaG 28.2 12 18.7 29.8 6.5 32.6952777953681 0.591513810348548 0.564091496228548 1.04861323792921 0.294356160632349 0.489999197151507 Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3536c hsaE 44.2 26.9 36.1 53 31.1 67.9660246693361 1.05034034450158 0.457226467388303 2.29719935178111 0.0216074000992296 0.0738739489879065 Probable hydratase II.B.6 - Aromatic hydrocarbons Rv3537 kstD 25.3 13 28.7 26 16 82.3662243728565 0.689462714471865 0.489552317461546 1.40835348925914 0.159026424238282 0.324652215937749 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3538 - 19.2 8.2 13.8 16.3 16.6 31.355857269635 1.252308814533 0.642722173125679 1.9484450154299 0.0513617379417628 0.142461453241757 Probable dehydrogenase Possible 2-enoyl acyl-CoA hydratase I.H.2 - Modification of fatty and mycolic acids Rv3539 PPE63 4.5 2.6 2.5 5 2.4 9.0052924448216 0.915724625250879 0.951250332625897 0.962653671534652 0.335721353394493 0.5370935111668 PPE family protein PPE63 IV.C.1.a - PE subfamily Rv3540c ltp2 42.3 12 25 27.2 0 39.3964432727807 -0.664257371894237 1.40176924074225 -0.473870700388966 0.635592113996177 0.789364399640414 Probable lipid transfer protein or keto acyl-CoA thiolase Ltp2 III.A.5 - Fatty acid transport Rv3541c - 39.2 27 19 21 3 14.3004838965633 -0.484438465706698 0.802407174970208 -0.603731473020147 0.546022185824234 0.724077342639249 hypothetical protein VI - Unknowns Rv3542c - 53.2 22.9 39.4 47.4 17.1 66.8584308790559 0.465221383708473 0.449406693590571 1.03519015257995 0.30058011671225 0.496805773865977 hypothetical protein VI - Unknowns Rv3543c fadE29 56.5 18.2 37.2 49.3 13.8 77.6945703989694 0.448594455228281 0.44609009021305 1.00561403418317 0.314601270268571 0.512329976685645 Probable acyl-CoA dehydrogenase FadE29 I.A.3 - Fatty acids Rv3544c fadE28 55.4 28.6 39.5 45.1 27.8 86.2677363923884 0.657091729597018 0.426896949550648 1.53922798063718 0.12374864895291 0.270900936088509 Probable acyl-CoA dehydrogenase FadE28 I.A.3 - Fatty acids Rv3545c cyp125 37.2 22.3 17.8 50 18.2 79.8195669400594 1.1959233037686 0.384926278033435 3.10688922013457 0.00189067234985611 0.0105294991559597 Probable cytochrome P450 125 Cyp125 IV.F - Cytochrome P450 enzymes Rv3546 fadA5 23.8 10.3 10 25.8 5.6 32.261553243262 0.805788480816487 0.557419130371665 1.44557019469213 0.148297791496388 0.307535584004804 Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv3547 ddn 100.1 70.1 66.3 143.8 37.3 75.5570890099371 0.895695146806508 0.40391420894878 2.21753809834427 0.0265863426044751 0.0866318541904792 Deazaflavin-dependent nitroreductase Ddn V - Conserved hypotheticals Rv3548c - 48.8 32.9 24.5 34.8 6.3 46.5086412137352 -0.120751328993793 0.498337441606625 -0.242308361588273 0.808541235193531 0.899451336386773 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3549c - 76.2 50.4 38.3 68.1 50 101.422617087104 1.07537041524932 0.414595035983893 2.59378507197346 0.00949258075809575 0.0380778267782278 Probable short-chain type dehydrogenase/reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3550 echA20 42.9 11.5 15 24.5 5.1 24.9452880412484 0.112097242245681 0.649144380583239 0.172684606997545 0.86289934385099 0.926740289848456 Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3551 - 47 25.8 20.4 22 5 35.0516914576942 -0.487473449171299 0.548440437499936 -0.888835716406044 0.374091377616665 0.575449954504683 Possible CoA-transferase (alpha subunit) I.A.2 - Amino acids and amines Rv3552 - 42.4 43.8 20.2 20.3 4.7 34.2504863388271 -0.737768509145725 0.576739855095253 -1.27920500486979 0.200824873886591 0.378967343263881 Possible CoA-transferase (beta subunit) VI - Unknowns Rv3553 - 34.4 18.6 18.2 17.1 5.5 36.4222971911731 -0.31233497880173 0.526923225893277 -0.592752346932967 0.553346903213588 0.729149825588738 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3554 fdxB 20 10.1 10.4 5.5 1.9 33.6211980091078 -1.14217349600938 0.565726184674937 -2.01895108791131 0.0434923035254078 0.126477618298025 Possible electron transfer protein FdxB I.B.6.c - Electron transport Rv3555c - 41.2 14.6 19.1 8 0 21.7764410429191 -1.82515415124424 0.780673043617436 -2.3379238801265 0.0193911972334351 0.0681385125008204 hypothetical protein V - Conserved hypotheticals Rv3556c fadA6 105.3 73.3 44.8 61.6 14.4 123.045396559723 -0.236743171054928 0.356799585183304 -0.663518627504297 0.506998453425844 0.691752127131873 Probable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase) I.A.3 - Fatty acids Rv3557c - 113.8 66.6 50.2 104.2 28.4 82.4620203690826 0.531270037089859 0.38341890498809 1.38561252504323 0.165865251600959 0.332858198963511 Transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3558 PPE64 8.9 4.9 3.7 5.1 5.9 21.6112214750859 0.933687387666843 0.72267839076177 1.2919818824009 0.196363418955306 0.373332919989101 PPE family protein PPE64 IV.C.2 - PPE family Rv3559c - 24.5 5.2 15.3 7.6 4.1 15.4577730270716 -0.755180542994888 0.825206840799639 -0.915140914565257 0.360117658214265 0.561360021694659 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3560c fadE30 13.3 11.4 8.6 10.5 0.7 16.2986617987989 -0.44154284599455 0.826943587592656 -0.53394554673305 0.593379208740617 0.759028225843 Probable acyl-CoA dehydrogenase FadE30 I.A.3 - Fatty acids Rv3561 fadD3 39.7 26.7 19.1 12.8 5.2 55.0742458510971 -0.941891124833414 0.461029844576972 -2.04301551388211 0.0410509023926305 0.120866414193431 Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) I.A.3 - Fatty acids Rv3562 fadE31 35.1 23.7 20.1 16 3.5 38.536691831512 -0.727399631247909 0.53230813249772 -1.36650106740765 0.17178174607282 0.341137575455343 Probable acyl-CoA dehydrogenase FadE31 I.A.3 - Fatty acids Rv3563 fadE32 22.3 11.8 14 8.5 0 17.2802481599844 -1.19742329432639 0.820198533498586 -1.45991884333021 0.144312379790639 0.303222333820855 Probable acyl-CoA dehydrogenase FadE32 I.A.3 - Fatty acids Rv3564 fadE33 14.8 13.1 12.1 5.1 2.1 15.7054681446525 -1.35111628548625 0.811089155238416 -1.66580489550386 0.0957522807702464 0.226707605941319 Probable acyl-CoA dehydrogenase FadE33 I.A.3 - Fatty acids Rv3565 aspB 12.3 3 8.6 6.6 1.7 12.4645447813132 -0.358788593375048 0.896270620222066 -0.400312790891385 0.688926148103941 0.827739625706974 Possible aspartate aminotransferase AspB (transaminase A) (ASPAT) (glutamic--oxaloacetic transaminase) (glutamic--aspartic transaminase) I.D.2 - Aspartate family Rv3566c nat 54.9 30 28.7 22.7 9.3 44.4010637346584 -0.5248875472383 0.492757701678025 -1.06520414688773 0.286783557448269 0.483018240837741 Arylamine N-acetyltransferase Nat (arylamine acetylase) I.C.1 - General Rv3566A - 106.1 76.2 40.3 50.2 0 22.4216598774429 -0.856014756666 0.74823956875871 -1.14403834334247 0.252607735719009 0.444696498197658 Hypothetical protein ? Rv3567c hsaB 76.5 48.3 35.9 53.5 24.5 52.650780299432 0.331721813505953 0.454418439191377 0.729991974129045 0.465395090468472 0.657923657604383 Possible oxidoreductase Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase V - Conserved hypotheticals Rv3568c hsaC 75.6 41.8 48.2 66.8 4.1 72.3244769627366 -0.114277095755046 0.503000695660339 -0.227190731028758 0.820275434834379 0.905041187604834 3,4-DHSA dioxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3569c hsaD 80 43.3 42.7 64.5 22.8 85.6490874245945 0.40840779280648 0.379747501222629 1.07547196885187 0.282163475549539 0.479109794053916 4,9-DHSA hydrolase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3570c hsaA 163.6 126.6 107.8 89.3 37.9 238.945333748275 -0.282759650722245 0.312541848496981 -0.904709727935766 0.365619186124949 0.566986642136875 Possible oxidoreductase Possible 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione hydroxylase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3571 kshB 32.9 19.6 15.5 24 8.8 41.6112357549931 0.334417167080043 0.491322017843789 0.680647630138098 0.496094481000563 0.683456496189807 Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3572 - 113.4 89.6 58.5 88.1 63.1 96.4808316343843 0.726815466424712 0.420088047373824 1.73015031246043 0.0836034231058966 0.205131049307984 hypothetical protein VI - Unknowns Rv3573c fadE34 4.6 2.4 2.4 2.7 0 8.23535058812973 -0.553502316261368 1.07325121605612 -0.515724844268359 0.606046600063429 0.76692285009813 Probable acyl-CoA dehydrogenase FadE34 I.A.3 - Fatty acids Rv3574 kstR 69.3 38 37.8 63.8 12.4 48.316928543983 0.336576748444315 0.478286037683352 0.703714350673026 0.481610681528878 0.669542764321112 Transcriptional regulatory protein KstR (probably TetR-family) I.J.1 - Repressors/activators Rv3575c - 11 4.8 5.5 3.8 0 8.39419042092615 -1.18241316006332 1.08956231641066 -1.08521847925004 0.277824901559386 0.473919913523427 Transcriptional regulatory protein (probably LacI-family) I.J.1 - Repressors/activators Rv3576 lppH 105.1 75.9 46.9 59.3 38.7 95.0615122740746 0.271196235798508 0.410250623247216 0.661050149423139 0.508580153078657 0.693109235169143 Possible conserved lipoprotein LppH V - Conserved hypotheticals Rv3577 - 43 33.8 20.7 12.6 4.5 33.901901107567 -1.19437662238643 0.569534339956296 -2.0971108124544 0.0359837670601927 0.109215512362641 hypothetical protein VI - Unknowns Rv3578 arsB2 14.4 9.5 7.4 3.6 0 13.5072199133591 -1.71191098656066 0.913074717776329 -1.87488597946266 0.0608084113036247 0.161456816219969 Possible arsenical pump integral membrane protein ArsB2 III.A.4 - Anions Rv3579c - 81.6 38.6 50.2 39 7.4 72.9652698684568 -0.602461371233998 0.439570865804731 -1.37056711010876 0.170509941659793 0.339105116989886 Possible tRNA/rRNA methyltransferase IV.H - Miscellaneous transferases Rv3580c cysS1 131.7 78.1 74.8 58.3 13.2 174.608167816962 -0.724628232994223 0.331544352014355 -2.18561477096991 0.0288438010355658 0.0921947808332832 Cysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3581c ispF 1131.3 526.1 441.7 584.5 113.5 460.258668686833 -0.315707175967066 0.295085589314924 -1.06988340806482 0.284671792332218 0.480916121351566 Probable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS) V - Conserved hypotheticals Rv3582c ispD 2362.6 1298.5 1234.8 1520.1 664.1 1938.12197411369 0.290222127015699 0.244029180402146 1.18929271711453 0.23432450021478 0.420241711271266 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT) V - Conserved hypotheticals Rv3583c - 12646.9 7846.1 6407.8 11840.5 5049.4 8838.52964342788 0.779260271360716 0.23034433638807 3.3830233622409 0.000716925333460674 0.00471122361988443 Possible transcription factor I.J.1 - Repressors/activators Rv3584 lpqE 276.1 243.8 124.3 328.7 160.3 269.981502629525 1.06955585193153 0.324260628713722 3.29844500756765 0.000972219214545092 0.00602028052083692 Possible conserved lipoprotein LpqE II.C.1 - Lipoproteins(lppA-lpr0) Rv3585 radA 68.2 42.6 29.1 25.9 9.4 89.1546912378785 -0.629804597116341 0.385016132990248 -1.63578755057595 0.101884058444692 0.235864924843855 DNA repair protein RadA (DNA repair protein SMS) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3586 - 38.6 18.3 15.5 14.4 5.8 35.0808220792374 -0.46944875305171 0.543600009706927 -0.863592245527748 0.387811925484752 0.5888863169926 hypothetical protein V - Conserved hypotheticals Rv3587c - 107.5 52.9 53.5 76.5 39 107.131003311731 0.554062421737076 0.374519924205273 1.47939371426711 0.139035119112291 0.29521584310508 Probable conserved membrane protein VI - Unknowns Rv3588c canB 75.8 46.1 26.5 34.9 10.5 41.5287349532706 -0.342926748902342 0.509743787621872 -0.672743360938663 0.501110576578926 0.686511020004468 Beta-carbonic anhydrase CanB IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3589 mutY 23.8 12.6 12.3 7.4 8.5 23.7326816375404 -0.231824462856501 0.698133403202845 -0.332063272997616 0.739841481985169 0.861879656654936 Probable adenine glycosylase MutY II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3590c PE_PGRS58 13.4 6.9 2.3 4.5 0 13.6355467673463 -0.917417773049624 0.930616382584766 -0.985817346672446 0.324222751873073 0.52390373500658 PE-PGRS family protein PE_PGRS58 IV.C.1.b - PE_PGRS subfamily Rv3591c - 5.3 0 0 0.9 0 1.03487758035169 -0.73609243440375 2.89919991589441 -0.253895024750877 0.799576658554945 NA Possible hydrolase V - Conserved hypotheticals Rv3592 mhuD 533.5 372.8 223.9 178.2 45.6 146.048311612004 -1.00245829331991 0.348158074047879 -2.87931938979549 0.00398534497313317 0.0190500565382425 Possible heme degrading protein MhuD V - Conserved hypotheticals Rv3593 lpqF 177.4 152 90.5 42.8 20 230.05310726598 -1.38195063976929 0.33303651561849 -4.14954689639013 3.33134035160303e-05 0.000358650684661943 Probable conserved lipoprotein LpqF II.C.1 - Lipoproteins(lppA-lpr0) Rv3594 - 49.2 28.3 18.4 14.4 6.8 32.8811123104971 -0.860669192262959 0.568521530516184 -1.51387264345384 0.130058143703353 0.281408640804689 hypothetical protein VI - Unknowns Rv3595c PE_PGRS59 50 25 29.5 42.1 11.8 79.2467050034228 0.361389957598602 0.399293998856909 0.905072349279433 0.365427059644032 0.566948158238792 PE-PGRS family protein PE_PGRS59 IV.C.1.b - PE_PGRS subfamily Rv3596c clpC1 879.9 536.6 479.3 555 162.6 2467.9609025719 -0.0982602175313979 0.224140426990683 -0.438386857965085 0.661105871551767 0.810241508491924 Probable ATP-dependent protease ATP-binding subunit ClpC1 II.B.3 - Proteins, peptides and glycopeptides Rv3597c lsr2 412.9 184.3 209.2 616.9 304.6 269.597755273881 1.67633348930986 0.313418169625816 5.34855235518477 8.86605297454345e-08 1.78429316112687e-06 Iron-regulated H-NS-like protein Lsr2 V - Conserved hypotheticals Rv3598c lysS 29 22.1 14.4 31.9 9.3 62.3378400061581 0.637956700144943 0.425104619846715 1.50070516847118 0.133431835675315 0.286607375355952 Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3599c - 43.6 38.2 24.9 20.5 14.1 4.64103774799411 -0.211886050368416 1.34834575815487 -0.157145190012961 0.875130423504585 NA Hypothetical short protein VI - Unknowns Rv3600c - 42.6 15.1 16.4 26.4 4.5 28.7684861216581 0.089114008472918 0.607003445270842 0.146809724338806 0.88328220894418 0.94007980290874 hypothetical protein V - Conserved hypotheticals Rv3601c panD 72.8 54.6 33.5 52.8 20.3 37.5732486427867 0.237416081840232 0.518361210962282 0.458012823528007 0.646943228361887 0.798422618417353 Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase) I.G.5 - Pantothenate Rv3602c panC 31 19.1 13.5 24.8 1.8 27.3446477217958 -0.0454460762585659 0.650447202613218 -0.0698689702653544 0.944297950893561 0.975168829392228 Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) I.G.5 - Pantothenate Rv3603c - 61.3 31.7 31.2 45 8.6 56.8024362257228 0.0554526011488103 0.458947087335018 0.120825695769873 0.903829096925702 0.952219708896739 Conserved hypothetical alanine and leucine rich protein VI - Unknowns Rv3604c - 101.1 57.8 49 26.4 13.2 104.602944991421 -1.02006934301756 0.38339766641181 -2.66060394306599 0.00780006475697043 0.0332464854021531 Probable conserved transmembrane protein rich in alanine and arginine and proline II.C.5 - Other membrane proteins Rv3605c - 91.8 52.1 42.7 18.5 12.9 36.8403297223969 -1.22958069626272 0.573565471152714 -2.14374950743041 0.0320529630530732 0.100027837122454 Probable conserved secreted protein VI - Unknowns Rv3606c folK 87.4 63.1 46.7 14.7 3.1 39.377273689603 -2.16708495101055 0.581120903909722 -3.72914644169677 0.000192129476545095 0.00155370457973225 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase FolK (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7,8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7,8-dihydropterin diphosphokinase) I.G.2 - Folic acid Rv3607c folB 161.8 111.3 87.8 56.1 14.9 59.9411045025367 -1.01225968110727 0.449503680360579 -2.25194970660811 0.0243254504447183 0.080754608268565 Probable dihydroneopterin aldolase FolB (DHNA) I.G.2 - Folic acid Rv3608c folP1 139.8 99 94.2 49 20.7 123.114993060141 -0.951663115713777 0.367933783427841 -2.58650648181214 0.00969543468326603 0.038629054722304 Dihydropteroate synthase 1 FolP (DHPS 1) (dihydropteroate pyrophosphorylase 1) (dihydropteroate diphosphorylase 1) I.G.2 - Folic acid Rv3609c folE 208.5 152.1 125.1 102.1 25.6 133.071797776437 -0.639562378925349 0.350106996915618 -1.82676263130924 0.0677354667132955 0.17398043734481 GTP cyclohydrolase I FolE (GTP-ch-I) I.G.2 - Folic acid Rv3610c ftsH 330.6 204.4 177.6 197.5 73.7 853.392551818358 -0.0131820066489168 0.241132952028225 -0.0546669650001787 0.956403788100986 0.980770763594005 Membrane-bound protease FtsH (cell division protein) III.C - Cell division Rv3611 - 7.3 2.6 3.2 2.3 3 4.05432585368017 -0.149328430947493 1.45370011371865 -0.102722995986774 0.91818282203145 NA Hypothetical arginine and proline rich protein VI - Unknowns Rv3612c - 425.8 182.8 328.9 1181.5 374.9 370.757813610615 2.01699018531934 0.327959114411835 6.15012694169709 7.74209566923981e-10 2.42677016464136e-08 hypothetical protein VI - Unknowns Rv3613c - 583.6 248.8 393.7 3589.5 1127.3 465.484566501508 3.24586360653928 0.298629953331936 10.8691829815592 1.6164182554523e-27 6.36150384534671e-25 Hypothetical protein VI - Unknowns Rv3614c espD 860.2 340.7 498.7 4863.6 1841 2352.41396308353 3.38365340329812 0.277519965434394 12.1924683797138 3.40935599769242e-34 3.01898473595664e-31 ESX-1 secretion-associated protein EspD V - Conserved hypotheticals Rv3615c espC 867.2 375.9 574.2 7113.2 2720.7 1882.05238394011 3.81724126397082 0.283201556478857 13.4788851849259 2.08229308843463e-41 7.37548211923545e-38 ESX-1 secretion-associated protein EspC V - Conserved hypotheticals Rv3616c espA 1075.3 437.5 802.8 5204.3 2589.6 6359.23474285482 3.21726234856022 0.325707985213233 9.87775091376392 5.19865817180134e-23 1.22757648296802e-20 ESX-1 secretion-associated protein A, EspA V - Conserved hypotheticals Rv3617 ephA 32.4 21.9 20.4 17.3 6.1 35.1482612846816 -0.333511192124281 0.538331615021694 -0.619527411762433 0.53556896944884 0.715303653766135 Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv3618 - 18.2 15.7 9.9 12.3 4.3 26.7630505825532 -0.0891641381747676 0.601649210785689 -0.148199543149618 0.882185292350796 0.940042209839506 Possible monooxygenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3619c esxV 19.6 11 12.2 32.4 13.8 10.7835172938789 1.45114308315385 0.881631066086902 1.64597544139944 0.0997688153045373 0.232487594610968 Putative ESAT-6 like protein EsxV (ESAT-6 like protein 1) V - Conserved hypotheticals Rv3620c esxW 27.3 44.1 23.1 35.2 18.5 17.8514834979312 0.52406203276963 0.75066294703394 0.698132277396044 0.485094474042733 0.672750441291841 Putative ESAT-6 like protein EsxW (ESAT-6 like protein 10) V - Conserved hypotheticals Rv3621c PPE65 3.3 4.3 2.4 3.1 0 5.1913825164405 -0.421899220156273 1.31813711841468 -0.320072331066505 0.748913499823575 NA PPE family protein PPE65 IV.C.2 - PPE family Rv3622c PE32 4 0.2 0 1.6 0 0.417709098394807 0.771261012707335 4.13260337268224 0.186628365500934 0.851952025025268 NA PE family protein PE32 IV.C.1.a - PE subfamily Rv3623 lpqG 41.4 37.5 31.2 15.9 5.6 34.0465351142898 -1.12711629524615 0.579267359778128 -1.94576179068308 0.0516833603677723 0.143017548767695 Probable conserved lipoprotein LpqG II.C.1 - Lipoproteins(lppA-lpr0) Rv3624c hpt 217.7 132.3 112.8 110.5 29.1 140.130164011326 -0.41074448916989 0.333842785431574 -1.23035304968146 0.218564926745965 0.401742070853248 Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphorylase) (imp diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase) I.F.4 - Salvage of nucleosides and nucleotides Rv3625c mesJ 42.9 14.9 21.1 37.3 15.2 51.2687753440564 0.789412596347676 0.472363405963265 1.67119761264713 0.0946826516651523 0.225228980656796 Possible cell cycle protein MesJ III.C - Cell division Rv3626c - 113 58 50 90.3 24.1 131.260262337687 0.377375922237827 0.336346673294196 1.12198500000547 0.261868817713805 0.455345779254933 hypothetical protein VI - Unknowns Rv3627c - 120 68.6 59.7 109 20.9 190.388526262466 0.30894727554948 0.325992990819323 0.947711405613348 0.343276392920097 0.54487031010848 hypothetical protein II.C.3 - Murein sacculus and peptidoglycan Rv3628 ppa 33.9 10 14 41 8.1 18.7247297859607 1.0733298678731 0.71725062660356 1.49645023379862 0.134536367362592 0.287932213412871 Inorganic pyrophosphatase Ppa (pyrophosphate phospho-hydrolase) (PPASE) (inorganic diphosphatase) (diphosphate phospho-hydrolase) I.A.4 - Phosphorous compounds Rv3629c - 33.6 30.3 12.9 24.6 0.9 35.6215027009704 -0.488175900297975 0.66915851364996 -0.729537008556006 0.465673238174531 0.657923657604383 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3630 - 28.2 8 8.3 12.3 0 21.772021532037 -0.559685579479706 0.777860157938748 -0.719519535442999 0.471820869959716 0.662119461726352 Probable conserved integral membrane protein II.C.5 - Other membrane proteins Rv3631 - 56.9 43.8 31.7 23.5 5.5 39.951518785959 -0.890789839330287 0.52840200847469 -1.68581842052736 0.0918307786832625 0.219476800334761 Possible transferase (possibly glycosyltransferase) IV.H - Miscellaneous transferases Rv3632 - 33 20.5 10.8 29.2 6.6 10.9217581780605 0.432600874425719 0.898993194087238 0.481205950468786 0.630370132140762 0.784685822827163 Possible conserved membrane protein VI - Unknowns Rv3633 - 108.6 46 50.4 319 89.7 237.092326531116 2.32520482323427 0.304082455737752 7.6466260363261 2.0632122882816e-14 1.62397731668743e-12 hypothetical protein V - Conserved hypotheticals Rv3634c galE1 28.3 14.6 6.8 23.2 6.3 27.5566332401539 0.642952318383495 0.603317821370273 1.06569422551318 0.286561888841817 0.483018240837741 UDP-glucose 4-epimerase GalE1 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase) I.C.3 - Sugar nucleotides Rv3635 - 8.6 6.8 3.3 4.8 1.1 14.2091951934902 -0.426809220276213 0.810728938407021 -0.52645119725816 0.598574751734054 0.762370287897167 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3636 - 31.6 30.3 14.4 89.3 14.3 24.1180527656556 1.74803465256559 0.647017951054162 2.7016787551529 0.00689903840163751 0.0300570652135302 Possible transposase IV.B.1.c - Others Rv3637 - 1.7 4.5 0 0 0 0.920965609238597 -1.96278788387943 3.05449632153166 -0.642589702938388 0.52049036632586 NA Possible transposase IV.B.1.c - Others Rv3638 - 0.7 0 0 0 0 0.0987469571131013 0.126759651879696 4.45882529160685 0.0284289344366787 0.977320047179988 NA Possible transposase IV.B.1.c - Others Rv3639c - 0.7 1.9 1.1 2 0 1.07756060235565 0.439133909239609 2.51487999773629 0.174614259779745 0.861382743050409 NA hypothetical protein V - Conserved hypotheticals Rv3640c - 2.9 4.1 0.3 1.1 1.6 3.95637525179498 -0.130565335060407 1.59008809749247 -0.0821120133320316 0.934557640128081 NA Probable transposase IV.B.1.c - Others Rv3641c fic 119 86.8 52.2 62.3 18 76.1533100260941 -0.362106292849006 0.407969814523397 -0.887581090458933 0.374766129003061 0.575887908428998 Possible cell filamentation protein Fic III.C - Cell division Rv3642c - 752.1 508.1 319.6 530.1 214.2 175.989920830352 0.328064036990175 0.317732354448366 1.03251693570756 0.301830018103002 0.498174242367584 Hypothetical protein VI - Unknowns Rv3643 - 0 0 0 0 0 0 NA NA NA NA NA Hypothetical protein VI - Unknowns Rv3644c - 30.6 15.5 24.1 27.3 22.3 67.4842052181376 0.980175127278533 0.49222974736647 1.99129600054176 0.0464483549053715 0.1328918199312 Possible DNA polymerase II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3645 - 275.8 166.2 111.9 109.4 38.8 412.386196599023 -0.506109723382842 0.268615709002887 -1.88414045202919 0.059545979736814 0.159298988087459 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3646c topA 91.3 62.7 53.8 55.1 24.6 314.881874612288 0.0169895059703112 0.290290851325008 0.0585258057316105 0.953329807718919 0.979180506404631 DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-closing enzyme) (TOPO I) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3647c - 99.2 79.2 38.6 31.5 5.1 47.4917858919958 -1.26240079883569 0.535834681125435 -2.3559520189776 0.0184753038981011 0.0655050314385126 hypothetical protein VI - Unknowns Rv3648c cspA 4387.6 3527.7 1477.6 1770.5 609.8 849.079771651911 -0.583786617456068 0.299430017955558 -1.94965962812291 0.0512167012326531 0.142170498249261 Probable cold shock protein A CspA III.E - Adaptations and atypical conditions Rv3649 - 5.3 3.2 3.5 2.3 0 10.5067266055359 -1.09389547737438 0.98954565819385 -1.10545225307844 0.268963672699909 0.464263805410856 Probable helicase II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3650 PE33 9.1 9.8 5.3 2 0 2.03758391632754 -1.66663250494365 1.9432036517576 -0.857672587963803 0.391073280616698 NA PE family protein PE33 IV.C.1.a - PE subfamily Rv3651 - 67.8 57.6 42.3 19.2 15.2 79.741318281307 -0.883788237328151 0.464447967363357 -1.902878900182 0.0570563487817692 0.15506744486081 hypothetical protein VI - Unknowns Rv3652 PE_PGRS60 24.7 20.8 35.6 22.5 16.3 16.4366411838057 0.233006122261119 0.811104428758692 0.287270188646005 0.773905447091454 0.881423631580758 PE-PGRS family-related protein PE_PGRS60 IV.C.1.b - PE_PGRS subfamily Rv3653 PE_PGRS61 6.6 1.4 5.2 4.4 6.2 6.7215645106329 1.39525450653546 1.2403083673233 1.12492549699278 0.260620606491238 NA PE-PGRS family-related protein PE_PGRS61 IV.C.1.b - PE_PGRS subfamily Rv3654c - 14.6 6.8 7.2 5.4 7.2 3.45898659121829 0.0946028424128716 1.55746947478725 0.0607413782063333 0.951565177457882 NA hypothetical protein VI - Unknowns Rv3655c - 25.3 12.2 12.9 9.8 0 6.84079331382825 -0.957931240971003 1.17732659713013 -0.813649537270349 0.415845750612769 NA hypothetical protein VI - Unknowns Rv3656c - 21.8 17.5 5.2 11 0 3.14154591469436 -0.487691525532162 1.65666572865252 -0.294381369214919 0.768466501727428 NA hypothetical protein VI - Unknowns Rv3657c - 9.4 5 6.5 1.8 0 3.68880737235061 -1.86520221324005 1.55794242607342 -1.1972215288732 0.23122022066323 NA Possible conserved alanine rich membrane protein VI - Unknowns Rv3658c - 18.9 13.7 3.6 8 2.5 11.6636868945832 -0.480189578560028 0.918096773670713 -0.523027193135801 0.600955329802567 0.763754495213739 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3659c - 21.1 16.6 9.8 12.7 5.6 26.8268639655799 -0.00821068451439095 0.603752658858412 -0.0135994175659878 0.989149569143185 0.996155108273772 hypothetical protein II.C.5 - Other membrane proteins Rv3660c - 70.8 30.7 37.8 55.9 11.5 78.6193634694174 0.230421477220578 0.414838620826476 0.555448469965292 0.578587947162208 0.748214132474823 hypothetical protein IV.E - Bacteriocin-like proteins Rv3661 - 70.2 64.8 51.6 57.7 29.4 97.5932918556646 0.268106054871047 0.402542311373399 0.666031985448483 0.505390656164047 0.690090094114516 hypothetical protein IV.E - Bacteriocin-like proteins Rv3662c - 19.5 13.1 8.3 2.1 2.6 11.2829304189473 -2.31195417118121 1.01750467790574 -2.27218038539121 0.0230756174725961 0.077693761490433 hypothetical protein VI - Unknowns Rv3663c dppD 21.1 13.4 11.7 7.2 0 27.7803414244487 -1.37674177146635 0.69568463122243 -1.97897396273825 0.0478189378471977 0.135934733430798 Probable dipeptide-transport ATP-binding protein ABC transporter DppD III.A.1 - Amino acids Rv3664c dppC 13.9 5.9 5.5 1.3 0 5.93435378742815 -2.60668511620669 1.33247375592722 -1.95627501450697 0.0504327658594551 NA Probable dipeptide-transport integral membrane protein ABC transporter DppC III.A.1 - Amino acids Rv3665c dppB 5.1 7.1 2.3 3.8 2.1 6.60808876185506 -0.099046434739641 1.14712571153866 -0.0863431389806342 0.9311936465508 NA Probable dipeptide-transport integral membrane protein ABC transporter DppB III.A.1 - Amino acids Rv3666c dppA 11.4 8.5 4.6 4.2 0 14.3090731901196 -1.20045796324243 0.882497653538101 -1.36029592648725 0.173736296924537 0.343592386212569 Probable periplasmic dipeptide-binding lipoprotein DppA III.A.1 - Amino acids Rv3667 acs 22 20.1 14 17.5 6 60.3545411876241 0.0754983047600062 0.445206900583878 0.169580266300886 0.865340242960559 0.928798527444333 Acetyl-coenzyme A synthetase Acs (acetate--CoA ligase) (acetyl-CoA synthetase) (acetyl-CoA synthase) (acyl-activating enzyme) (acetate thiokinase) (acetyl-activating enzyme) (acetate--coenzyme A ligase) (acetyl-coenzyme A synthase) I.A.3 - Fatty acids Rv3668c - 20.8 4.8 13.2 28.5 9.9 21.6419441680824 1.24731260954579 0.680167226773223 1.83383227013621 0.0666788959282328 0.172391714874307 Possible protease II.B.3 - Proteins, peptides and glycopeptides Rv3669 - 66.4 40.2 38.6 48.2 4 33.812755494132 -0.324201211931534 0.612698048764353 -0.529137007348663 0.596710410965236 0.761090484565671 Probable conserved transmembrane protein VI - Unknowns Rv3670 ephE 20.9 8.7 4.2 7.2 6 17.966843448349 0.206698135572389 0.781171349642171 0.264600251490368 0.791317426374863 0.892058028077582 Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) III.F - Detoxification Rv3671c - 67.9 44.1 16.2 21.9 6.8 61.6590743675269 -0.783681781502419 0.486364766571309 -1.61130459146349 0.107113350516871 0.244284185198824 Membrane-associated serine protease II.B.3 - Proteins, peptides and glycopeptides Rv3672c - 73.6 33.4 36.6 32.5 4 47.8674848659207 -0.736063455673389 0.533020121942231 -1.38092996000095 0.167300497025899 0.334790034161432 hypothetical protein V - Conserved hypotheticals Rv3673c - 118.8 66.6 55.1 55.8 10.1 70.3284787093041 -0.602913063428787 0.437707664289974 -1.37743318798587 0.168378357961005 0.336187228803765 Possible membrane-anchored thioredoxin-like protein (thiol-disulfide interchange related protein) I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3674c nth 78.8 57.8 38 90.6 39.6 94.562487627645 0.978518888142385 0.374776770892478 2.61093793463287 0.00902942793577012 0.0365270761792879 Probable endonuclease III Nth (DNA-(apurinic or apyrimidinic site)lyase) (AP lyase) (AP endonuclease class I) (endodeoxyribonuclease (apurinic or apyrimidinic)) (deoxyribonuclease (apurinic or apyrimidinic)) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3675 - 67.8 29.6 9.2 283.2 78.3 80.3223350083807 3.17219247154668 0.476414936469635 6.65846561204293 2.76701009790714e-11 1.12652296169966e-09 Possible membrane protein VI - Unknowns Rv3676 crp 121.4 56.2 85.1 213.7 75.8 162.585859718059 1.47389176477584 0.346820058289425 4.24973045689839 2.14027907482127e-05 0.000247377419135755 Transcriptional regulatory protein Crp (Crp/Fnr-family) I.J.1 - Repressors/activators Rv3677c - 276.4 171.6 130.6 101.9 24 191.581881975745 -0.885668164534055 0.317935114422159 -2.78568841363666 0.00534141879049618 0.0243178732081459 Possible hydrolase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3678c - 363.9 195 203.9 90.8 46.8 146.626454398791 -1.07495235120424 0.361303238960943 -2.97520817775023 0.00292789777729932 0.0150516892992659 hypothetical protein I.J.1 - Repressors/activators Rv3678A - 846.2 507.8 332.3 217.5 85.5 109.451619505841 -1.10877931510461 0.37303027231022 -2.97235746642708 0.00295522389660412 0.0151456207016507 hypothetical protein ? Rv3679 - 480.6 333.5 250.1 822.3 365.5 1045.17142143066 1.60980947702699 0.252731046338645 6.36965462039018 1.89454340653346e-10 6.64403242172427e-09 Probable anion transporter ATPase III.A.4 - Anions Rv3680 - 329.8 184.9 150.6 413 133.2 573.246289385386 1.07859349549547 0.244456726615758 4.41220624372845 1.02322571773681e-05 0.000132756977737135 Probable anion transporter ATPase III.A.4 - Anions Rv3681c whiB4 145.3 83.5 59.4 251.9 65.3 87.032110042527 1.45874818766036 0.380296283449949 3.83582025684547 0.000125145911819074 0.00109448597447694 Probable transcriptional regulatory protein WhiB-like WhiB4 I.J.1 - Repressors/activators Rv3682 ponA2 367.6 242.2 213.2 158.5 66.3 947.682713620869 -0.47115428152868 0.252065247528644 -1.86917588262594 0.0615983484716028 0.162216617313321 Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase)] II.C.3 - Murein sacculus and peptidoglycan Rv3683 - 131.4 88.1 72.5 45.6 14.1 117.952290607884 -0.978035339218369 0.357633305854623 -2.7347434458913 0.00624289124343119 0.0276777596582065 hypothetical protein V - Conserved hypotheticals Rv3684 - 134.5 74.9 58.9 76.8 16.5 131.473661965514 -0.228195922215095 0.349706594137185 -0.652535371196281 0.514055862452929 0.698421889071068 Probable lyase IV.I - Miscellaneous phosphatases, lyases, and hydrolases Rv3685c cyp137 91.6 69.3 46.4 46.7 11.5 133.487238815093 -0.549105009224152 0.351254265324411 -1.56326929928384 0.117989266223584 0.263172532093158 Probable cytochrome P450 137 Cyp137 IV.F - Cytochrome P450 enzymes Rv3686c - 325.2 270.2 126 273.8 84.4 136.052779803228 0.330529977616961 0.357254188862847 0.925195527221247 0.354864209682131 0.554445977368376 hypothetical protein V - Conserved hypotheticals Rv3687c rsfB 185.7 169.9 74.7 102.7 60.7 85.684868403371 0.0470521064201366 0.434262289317504 0.10834951037099 0.913718450150259 0.95801370906451 Anti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B) V - Conserved hypotheticals Rv3688c - 403.7 313.9 184.7 110.7 41.7 170.017806787514 -1.21264850748044 0.339892253668246 -3.56774387881181 0.00036006819774391 0.00264597833279861 hypothetical protein V - Conserved hypotheticals Rv3689 - 40.5 27.7 22.9 25.2 5.8 58.7308224118414 -0.286603786658244 0.447752051468922 -0.640094859907387 0.522110930505272 0.704395037915461 Probable conserved transmembrane protein VI - Unknowns Rv3690 - 50.2 36 40.2 27.2 0 32.9499618588732 -1.03821273916767 0.673056263507613 -1.54253484509163 0.122943677162393 0.269906518364127 Probable conserved membrane protein VI - Unknowns Rv3691 - 46.4 33.1 17.1 22.6 3.9 41.1856202969483 -0.550550505226046 0.535270896947637 -1.02854556144476 0.303693270493337 0.499852027921654 hypothetical protein VI - Unknowns Rv3692 moxR2 64.3 36.7 22.9 12.8 2.7 47.4034204088831 -1.65092800842905 0.52547754061947 -3.14176702296891 0.00167931602800612 0.00951701979391628 Probable methanol dehydrogenase transcriptional regulatory protein MoxR2 I.J.1 - Repressors/activators Rv3693 - 44.2 22.5 20.3 6.8 3 41.7892228984408 -1.85278644993826 0.543657504046694 -3.4080030830939 0.000654401553053943 0.00435040722746517 Possible conserved membrane protein V - Conserved hypotheticals Rv3694c - 108.1 63.4 43.3 64.9 13 99.9314365955144 -0.1720689486889 0.386249761134435 -0.445486226796686 0.655968411074206 0.805868918214254 Possible conserved transmembrane protein V - Conserved hypotheticals Rv3695 - 53.9 34.9 23.4 30.3 10.2 52.0668070877606 -0.0910850752557924 0.456192498619155 -0.199663684807394 0.841743617160921 0.91350881138875 Possible conserved membrane protein V - Conserved hypotheticals Rv3696c glpK 23.8 26 13.2 10 2.5 40.7166595062509 -1.04013189846838 0.553493710860634 -1.87921177433267 0.0602155825609686 0.160605115535355 Probable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK) I.A.1 - Carbon compounds Rv3697c vapC48 56.8 36.5 35.4 62.5 21.9 37.7798678691559 0.736275972942751 0.511538253182712 1.43933707471876 0.150055043378917 0.310452665682316 Possible toxin VapC48 Contains PIN domain V - Conserved hypotheticals Rv3697A vapB48 86.7 80.8 48.8 104.4 37 32.6944996785763 0.761441308147716 0.548974722425998 1.38702435110819 0.165434337596297 0.332631377435323 Possible antitoxin VapB48 ? Rv3698 - 21.9 19.6 16.1 12.4 5.8 44.6147291521343 -0.37094832918335 0.510907151061571 -0.72605820531693 0.467803089271372 0.66014284549769 hypothetical protein VI - Unknowns Rv3699 - 83 54.9 37.4 80.7 8.4 64.0852815361649 0.243747313337437 0.471976079884484 0.516439971697493 0.605547154377555 0.76692285009813 hypothetical protein IV.H - Miscellaneous transferases Rv3700c - 28.5 20.2 9.6 7.3 0.1 23.2341214964321 -1.61958131513733 0.755873615074085 -2.14266152811616 0.0321402866997884 0.100212055889657 hypothetical protein IV.D - Antibiotic production and resistance Rv3701c - 83.5 45.4 39.5 22.6 4.8 61.5221441679051 -1.33405428524836 0.467188354257995 -2.85549558992572 0.00429697196301587 0.0202661447310282 hypothetical protein V - Conserved hypotheticals Rv3702c - 61.3 57.2 40 14.6 14.8 49.6863314871144 -1.11909675550193 0.559046321559403 -2.0017961166086 0.0453066637937547 0.130199350841148 hypothetical protein V - Conserved hypotheticals Rv3703c - 68.2 50.5 23.3 32.4 1.5 70.894559423239 -0.899009723891632 0.54221734620157 -1.65802464673903 0.0973124917423881 0.22856820010049 hypothetical protein V - Conserved hypotheticals Rv3704c gshA 78.8 52.9 39.4 53.6 12.2 110.501179931543 -0.0880610367644414 0.3617691042752 -0.243417792519542 0.807681761815713 0.898777505608312 Glutamate--cysteine ligase GshA (gamma-glutamylcysteine synthetase) (gamma-ECS) (GCS) (gamma-glutamyl-L-cysteine synthetase) I.D.1 - Glutamate family Rv3705c - 62.7 30.4 46.9 41 14.9 48.885179520562 -0.0236160268167487 0.493017151410271 -0.0479010248410128 0.961795122625055 0.984368768463478 hypothetical protein VI - Unknowns Rv3705A - 24.5 7.3 15.9 4.4 9.6 9.86179939189787 -0.275610597198285 1.0767862386036 -0.255956648884836 0.797984311636403 0.895015969542792 Conserved hypothetical proline rich protein ? Rv3706c - 91 122 84.6 34 7.6 38.5395699745529 -1.58487951411124 0.603609291527091 -2.62567116901332 0.00864783161172407 0.035528959966192 Conserved hypothetical proline rich protein VI - Unknowns Rv3707c - 91.3 45.6 44.5 32.4 10.3 78.2344766674142 -0.766211061259181 0.405843389600393 -1.88794761943423 0.0590329828032301 0.158521489957456 hypothetical protein V - Conserved hypotheticals Rv3708c asd 226.3 116.6 114.2 125.6 38.3 235.446386172941 -0.147292071622741 0.293275115970614 -0.502231739420741 0.615504519051483 0.774334706627567 Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic semialdehyde dehydrogenase) (L-aspartate-beta-semialdehyde dehydrogenase) I.D.2 - Aspartate family Rv3709c ask 382.1 245.5 188.2 170.1 67.5 491.035091404818 -0.38061916758194 0.260156023291869 -1.46304191909839 0.143455908947777 0.302093239888839 Aspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); and aspartokinase beta subunit (Ask-beta)] I.D.2 - Aspartate family Rv3710 leuA 291.1 158.7 156.3 141.1 55.7 580.049047756505 -0.223670208243132 0.25952130842522 -0.861856814765489 0.388766315822979 0.589473583324055 2-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS) I.D.7 - Branched amino acid family Rv3711c dnaQ 135.3 96.4 80.4 59.3 10.6 129.480963661144 -0.930329176360746 0.377730451176124 -2.46294460365591 0.0137801204869642 0.0515408519163962 Probable DNA polymerase III (epsilon subunit) DnaQ II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3712 - 12.7 4.3 6.7 5.3 0 10.9262746136236 -0.861116794520037 0.9788451995251 -0.879727248943775 0.379007084154183 0.579461267126646 Possible ligase V - Conserved hypotheticals Rv3713 cobQ2 19.7 8.6 11.2 5.4 1.5 9.54228392574839 -1.48143066123215 1.0544669823501 -1.40490948131014 0.160048196833997 0.325799260451735 Possible cobyric acid synthase CobQ2 I.G.13 - Cobalamin Rv3714c - 24.5 11.2 16.5 11 1.7 19.096610105587 -0.755975149459778 0.737952976774246 -1.02442184428107 0.305636068625469 0.501651044982118 hypothetical protein V - Conserved hypotheticals Rv3715c recR 86.8 58.6 42.4 119.6 49.6 93.5077974247213 1.24829955662991 0.370354177624407 3.37055616501205 0.000750166122764451 0.0048487014723206 Probable recombination protein RecR II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3716c - 136 75.5 60.9 94.6 33.7 60.9893234615481 0.270573080507257 0.425170520885025 0.636387207523322 0.524524076757896 0.706143777984214 hypothetical protein V - Conserved hypotheticals Rv3717 - 131.2 88.2 55.3 90.6 38.6 113.765449919445 0.316548476643675 0.35618666172402 0.888715133552481 0.374156195715495 0.575449954504683 hypothetical protein II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3718c - 43.5 27.2 28.9 14.9 15.7 22.7851214403155 -0.424042070788561 0.699850473890193 -0.605903813183805 0.544578627195663 0.722928367789082 hypothetical protein VI - Unknowns Rv3719 - 134.6 78.9 67.4 142.3 75.2 308.404383000269 1.12720982321327 0.300627596620241 3.74952211934548 0.000177171869838591 0.00145601569134174 hypothetical protein V - Conserved hypotheticals Rv3720 - 172.7 110 99.9 224.6 66.4 342.944797671077 0.903229806065861 0.270033207440141 3.34488418897918 0.000823169347430399 0.00524390925000069 Possible fatty acid synthase I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3721c dnaZX 48.3 26 15.1 33.8 3.4 72.6036873733465 -0.000246218552655094 0.473614441000998 -0.000519871294749171 0.999585202738999 0.999585202738999 DNA polymerase III (subunit gamma/tau) DnaZ/X II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3722c - 206.8 98.2 115.9 182.6 91.8 386.113825202811 0.860128795392902 0.302019342078553 2.84792619397597 0.00440051286434613 0.0206737099185333 hypothetical protein VI - Unknowns Rv3723 - 211.8 118.1 73.7 207.1 55.3 192.96004897175 0.723243553856892 0.316040351373927 2.28845320134826 0.0221111424761664 0.07516090849384 Probable conserved transmembrane protein VI - Unknowns Rv3724A cut5a 68.3 43.3 32.9 93 36.6 27.6537177453428 1.20758714425246 0.577627558987169 2.09059821586401 0.0365640958270477 0.110727817312671 Probable cutinase precursor [first part] Cut5a ? Rv3724B cut5b 60.7 25.6 24.9 65.8 12 37.996558702026 0.746622957359234 0.533154672595306 1.40038715917991 0.161397413159328 0.327416745366748 Probable cutinase [second part] Cut5b ? Rv3725 - 120.2 61.6 59.7 57.2 9.5 96.9474766738067 -0.591288788978611 0.402376301910676 -1.46949208035087 0.141699368334022 0.29943817289329 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3726 - 67 32.8 35.1 31.8 7 72.0372382319558 -0.481358288955912 0.423379954368185 -1.13694161471166 0.255562693915083 0.447579484765417 Possible dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3727 - 31.6 16.9 25.1 8.7 1.1 50.0432229088133 -1.7117586822071 0.570738586708264 -2.99919914663501 0.00270690311807307 0.0141832113080101 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3728 - 14.4 9.5 7.4 3.3 0.6 36.0470008414689 -1.71395217740867 0.589856902074807 -2.90570843772427 0.00366422706807284 0.0178034187587298 Probable conserved two-domain membrane protein II.C.5 - Other membrane proteins Rv3729 - 32 27.8 22 12.1 5.8 86.0345308910078 -0.871490689982996 0.418086108104786 -2.08447655420441 0.0371168407170923 0.112117463956123 Possible transferase IV.H - Miscellaneous transferases Rv3730c - 17.3 11.6 8.4 9.8 1.9 16.5258871911382 -0.430549524587601 0.75828454687738 -0.567794143188869 0.570174757188873 0.741939379119394 hypothetical protein V - Conserved hypotheticals Rv3731 ligC 28.1 13.7 9.6 12.3 7.3 28.7003632651801 -0.00224391589245146 0.597683294399363 -0.00375435605023303 0.997004464308871 0.999433305040629 Possible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase) II.A.5 - DNA replication, repair, recombination and restriction/modification Rv3732 - 43.6 42.2 17.8 22.4 19.7 64.6096761718899 0.236097800685011 0.507146876398094 0.465541269546697 0.641543890016079 0.794249723326443 hypothetical protein V - Conserved hypotheticals Rv3733c - 101.2 53.8 43.8 133.1 48.2 79.5021928958676 1.24048560534698 0.386916252963852 3.20608295941208 0.00134555190011573 0.00798315716953085 hypothetical protein VI - Unknowns Rv3734c tgs2 87 56.2 36.1 161.7 58.8 238.762582695551 1.69596035599445 0.29133011370626 5.82143855442433 5.8343255114851e-09 1.55377300463761e-07 Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2 V - Conserved hypotheticals Rv3735 - 79.4 45.4 42.6 72.3 9.2 41.5850482595268 0.157255461883258 0.537466420287771 0.292586580197997 0.7698381725547 0.879602195867338 hypothetical protein V - Conserved hypotheticals Rv3736 - 34.7 24.9 22.3 30.3 10.5 50.4562821435162 0.319238538057526 0.461171632395967 0.692233684016852 0.488790588503423 0.676816366098172 Transcriptional regulatory protein (probably AraC/XylS-family) I.J.1 - Repressors/activators Rv3737 - 54.9 33.5 18.9 21.9 1.2 64.5226984874341 -0.997944723042798 0.537055156859012 -1.85817920244788 0.0631435704003044 0.165485050649362 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3738c PPE66 10.1 12.7 1.8 2.3 0.7 7.50813393625254 -1.85202301864299 1.27279868002269 -1.4550793049298 0.145647307731294 0.304535279801796 PPE family protein PPE66 IV.C.2 - PPE family Rv3739c PPE67 21.8 4.2 13.7 10.2 7.4 4.5860449250905 0.0504461892865564 1.43089186446538 0.0352550675137177 0.971876351967818 NA PPE family protein PPE67 IV.C.2 - PPE family Rv3740c - 33.3 44 16.5 21.3 10.3 64.9435385324512 -0.20965860166771 0.49211668611379 -0.426034328003322 0.670082832281912 0.81645455519179 Possible triacylglycerol synthase (diacylglycerol acyltransferase) V - Conserved hypotheticals Rv3741c - 41.9 26.6 37.6 50.1 12.5 44.4885983169087 0.48480566486521 0.511979944601783 0.946923155832386 0.343677937535924 0.54487031010848 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3742c - 66.7 70.5 30 66.2 12.3 35.2668075212381 0.202532709538316 0.567650164396927 0.356791422325204 0.721247958202226 0.849224787904526 Possible oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3743c ctpJ 2.6 1.7 0.5 0.2 1 3.87396472947277 -1.43626947095947 1.64578023857447 -0.872698211641868 0.382827592734276 NA Probable cation transporter P-type ATPase CtpJ III.A.2 - Cations Rv3744 nmtR 170.4 80.4 109 30.4 5.4 46.4686639934003 -2.06976456690146 0.568296879944428 -3.64204809131426 0.000270477526556828 0.00211020131952486 Metal sensor transcriptional regulator (ArsR-SmtB family) I.J.1 - Repressors/activators Rv3745c - 5.5 4 2.5 4.5 3.6 0.503129951200834 1.06644310803735 3.82832226054155 0.278566702450617 0.780577369114619 NA hypothetical protein V - Conserved hypotheticals Rv3746c PE34 8.1 7.9 5.2 21.7 0 4.36863368136854 1.38657263677276 1.39143012891533 0.996508993127555 0.319002899709803 NA Probable PE family protein PE34 (PE family-related protein) IV.C.1.a - PE subfamily Rv3747 - 59.3 58.9 22 86 57.6 51.2783788309666 1.578284616416 0.511166872218469 3.0876113108939 0.00201772190637721 0.0111494087244744 hypothetical protein V - Conserved hypotheticals Rv3748 - 44.4 23.8 17.5 37.1 5.5 14.9188082945661 0.23022154778059 0.792717447133457 0.290420689759123 0.771494417317993 0.880642354540874 hypothetical protein V - Conserved hypotheticals Rv3749c - 129.4 103.5 98.5 178.8 85.4 134.017687253139 1.04622313889313 0.364108972679573 2.87337917325601 0.00406106385901243 0.0193597418420216 hypothetical protein VI - Unknowns Rv3750c - 384.4 331 283.2 537 629 471.492948399371 1.98523434703206 0.694381260452876 2.85899758547242 0.00424982019444587 0.0201241485678172 Possible excisionase IV.B.3 - Phage-related functions Rv3751 - 0.1 4 5 1.3 4 0.373158608957406 0.689815501671121 4.41343979630867 0.156298835717227 0.875797474024338 NA Probable integrase (fragment) IV.B.3 - Phage-related functions Rv3752c - 51.1 25.9 23.9 17.5 0 16.7759753457332 -1.20705661947601 0.826461683914479 -1.46051128923348 0.144149607178329 0.303193532438029 Possible cytidine/deoxycytidylate deaminase I.F.3 - 2'-deoxyribonucleotide metabolism Rv3753c - 143.1 88.7 63.3 72.9 11.8 64.429155992718 -0.485212391627769 0.446839465004779 -1.08587631493691 0.277533717009255 0.473746711155076 hypothetical protein VI - Unknowns Rv3754 tyrA 45.6 31 25.1 27.7 12.3 49.3775941828551 0.001687514987366 0.469275264350307 0.00359600242237847 0.997130811370267 0.999433305040629 Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase) I.D.4 - Aromatic amino acid family Rv3755c - 382.3 229.7 155.7 310.4 118.4 283.394374514332 0.577580251258168 0.282914925675164 2.04153333331495 0.0411978441302648 0.121097729385393 hypothetical protein VI - Unknowns Rv3756c proZ 68.2 31.4 44.8 9.4 5.5 38.9918946269913 -2.06322674860224 0.597756894917437 -3.45161514011013 0.00055724194268661 0.00381033004053276 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProZ III.E - Adaptations and atypical conditions Rv3757c proW 105.8 74.3 60.9 19.4 5.7 61.2233838449753 -1.96895238385201 0.473496010801504 -4.15832940285831 3.20583516069189e-05 0.000346191101803984 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter ProW III.E - Adaptations and atypical conditions Rv3758c proV 141.9 84.3 66.6 69.1 7.1 137.620717387523 -0.767350486823181 0.409473374067951 -1.87399361086623 0.0609313057380093 0.161661936272681 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter ProV III.E - Adaptations and atypical conditions Rv3759c proX 274.4 185 104.9 117.4 23.6 225.649349789779 -0.722682879708017 0.332770505769384 -2.17171554323041 0.0298771254090253 0.0945910924602623 Possible osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein ProX III.E - Adaptations and atypical conditions Rv3760 - 59 38.3 23.8 101.7 27.5 30.9159223338027 1.45473943644739 0.554200403905714 2.62493391595377 0.00866657860270747 0.035528959966192 Possible conserved membrane protein V - Conserved hypotheticals Rv3761c fadE36 18.4 9.8 7.2 7.2 5.7 20.1877725683101 0.00540760911759511 0.710848992957281 0.00760725438337941 0.993930347719577 0.997874515766084 Possible acyl-CoA dehydrogenase FadE36 I.A.3 - Fatty acids Rv3762c - 22.1 14.7 12.7 15.2 10.1 59.8707194817002 0.49543920915261 0.467291757979983 1.06023528275847 0.289037573310306 0.485199566191992 Possible hydrolase I.C.5 - Sulphur metabolism Rv3763 lpqH 513.3 308 231.7 573.6 173.3 342.200354127658 0.852016953979906 0.265023674264146 3.21487111046054 0.00130503104337474 0.00778185177716048 19 kDa lipoprotein antigen precursor LpqH II.C.1 - Lipoproteins(lppA-lpr0) Rv3764c tcrY 28.8 13.9 16.3 14.8 7.3 43.9889258768339 -0.0943662679993173 0.499501374563241 -0.188920937568651 0.850154783259756 0.918623624864569 Possible two component sensor kinase TcrY I.J.2 - Two component systems Rv3765c tcrX 40.6 27.1 16.5 35.4 6.2 30.6496864083519 0.250228287859301 0.580281302894029 0.431218939178878 0.666309184231464 0.813535722353618 Probable two component transcriptional regulatory protein TcrX I.J.2 - Two component systems Rv3766 - 56.7 41.8 23.9 53.2 26.7 57.8854811547549 0.82832679701218 0.449300150197499 1.84359341221691 0.0652424168237545 0.16929570724523 Hypothetical protein VI - Unknowns Rv3767c - 86.3 71.1 28.9 57.7 12.2 84.5470032901137 -0.126728005822256 0.43310567419478 -0.29260296821986 0.769825644713167 0.879602195867338 Possible S-adenosylmethionine-dependent methyltransferase V - Conserved hypotheticals Rv3768 - 26.6 14.4 19.2 24.2 7.7 12.3712067372188 0.352032413833134 0.831391173771952 0.42342572899348 0.671984676232395 0.817591999101511 hypothetical protein VI - Unknowns Rv3769 - 503.7 331.2 257.1 307.5 102.7 152.531154858475 -0.0767279245953752 0.320558379003632 -0.239357101922785 0.810828690975306 0.900180115344522 Hypothetical protein V - Conserved hypotheticals Rv3770c - 19.9 3 3.1 7 9.2 9.95437006551306 1.03902375486096 1.07810603258096 0.963749133629801 0.335171714377114 0.536699010996264 Hypothetical leucine rich protein VI - Unknowns Rv3770A - 9.8 0 8.7 6 0 1.287460012701 -0.131203460198797 2.42570145145561 -0.0540888740121191 0.956864356524297 NA Probable remnant of a transposase ? Rv3770B - 31.4 17.9 28.2 28.4 25.2 11.7565166681909 0.921372025730291 0.90331136691915 1.01999383542879 0.307731384388268 0.503922590616387 Probable remnant of a transposase ? Rv3771c - 19.2 14 20.8 26.5 5 9.98886014016819 0.416870596290043 0.945983874965818 0.440674103779101 0.659448946771774 0.808783992197238 hypothetical protein V - Conserved hypotheticals Rv3772 hisC2 30.1 14.8 14.6 11.7 3.8 27.5279063869807 -0.644012937508421 0.599680900277619 -1.07392604501874 0.282855829037477 0.479672311253634 Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase) I.D.5 - Histidine Rv3773c - 37.3 15 18.5 13.7 0 15.0203855882499 -1.04503987782784 0.865461682296381 -1.20749410309532 0.227241914684836 0.410658602966168 hypothetical protein V - Conserved hypotheticals Rv3774 echA21 327.2 218.1 105.3 84.3 16.7 200.148279453739 -1.37399488430417 0.363232471745256 -3.7826873729169 0.000155144223906551 0.0013052751569525 Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) I.A.3 - Fatty acids Rv3775 lipE 91.5 68.6 48.6 21.2 7 100.557066154929 -1.56890217000618 0.390254744741135 -4.02020011581632 5.81487262275568e-05 0.000568706477583478 Probable lipase LipE II.B.5 - Esterases and lipases Rv3776 - 73.7 43.2 42.3 9 11.4 102.67946746047 -1.44365323697048 0.496585276751885 -2.90716077289539 0.00364725691249096 0.0177697166217923 hypothetical protein V - Conserved hypotheticals Rv3777 - 75.7 50.6 34.9 35.7 16.5 78.3781488040825 -0.255503602175504 0.403133489360202 -0.633794038250218 0.526215244421829 0.707123046963007 Probable oxidoreductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3778c - 88 43.2 31.7 72.2 16.6 109.174107221546 0.436950695379136 0.369077703580764 1.18389892193398 0.236453076987928 0.422774759561455 Possible aminotransferase V - Conserved hypotheticals Rv3779 - 39.8 18.5 17 27.9 5.3 76.2948548863729 0.136869885665298 0.415495148819616 0.329413919883621 0.741842847849374 0.862925243705248 Probable conserved transmembrane protein alanine and leucine rich II.C.5 - Other membrane proteins Rv3780 - 142 82.6 68.1 91.2 29.2 82.1013821374197 0.0772974458954184 0.383841164784081 0.201378728982599 0.840402446324553 0.91350881138875 hypothetical protein VI - Unknowns Rv3781 rfbE 101.1 51.3 45.6 60.9 16.8 81.1668831016819 -0.0234838946485679 0.391936862660534 -0.0599175451095752 0.952221306023636 0.978748655233813 Probable O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter RfbE II.C.5 - Other membrane proteins Rv3782 glfT1 362.4 243.2 155.4 141.2 33.9 294.089799792494 -0.813421579991661 0.296638957961688 -2.74212660933335 0.00610428076516183 0.0271625156660844 UDP-galactofuranosyl transferase GlfT1 II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3783 rfbD 152 88.3 66.3 63.3 14.6 110.425424540237 -0.649104511241449 0.367285259866238 -1.76730346183195 0.0771774204003417 0.192508748632402 Probable O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter RfbD II.C.5 - Other membrane proteins Rv3784 - 67 68.1 37.7 23 7.6 70.1004537075478 -1.18874817439877 0.453766610860433 -2.61973478424221 0.00879981746258328 0.0358676104171116 Possible dTDP-glucose 4,6-dehydratase I.C.3 - Sugar nucleotides Rv3785 - 157.1 103 65.4 60.2 11 142.804630465392 -0.885730552314432 0.360646047852209 -2.45595524362269 0.0140510655923273 0.0524434924425957 Hypothetical protein VI - Unknowns Rv3786c - 24.4 16.2 12.9 13.5 3.2 30.0320164462556 -0.378097758904786 0.575047795662604 -0.657506665979164 0.510855186195562 0.69558912688403 hypothetical protein VI - Unknowns Rv3787c - 8.7 6.5 6 3.8 0 7.09626182370135 -1.0928835114917 1.16516867611866 -0.937961630699041 0.348264128706242 NA hypothetical protein V - Conserved hypotheticals Rv3788 - 10.6 6.6 3.9 21.1 16.8 14.1504038941258 2.38113036410393 0.837393519984768 2.8435022570359 0.00446206933638563 0.0208514367584066 Hypothetical protein VI - Unknowns Rv3789 - 15.6 17.1 13.9 18.9 0 7.8600736991359 -0.0692944256616589 1.09889038016918 -0.063058542428036 0.949719886913441 0.977994521000095 GTRA family protein V - Conserved hypotheticals Rv3790 dprE1 14.9 14.3 8.4 12.3 7.5 33.0486730296796 0.444352246075103 0.569051832756018 0.780864273686681 0.434882326482688 0.630001308957742 Decaprenylphosphoryl-beta-D-ribose 2'-oxidase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3791 dprE2 35.7 34.2 22.5 22.4 1.9 29.9804176740559 -0.687993242077218 0.637150342631888 -1.07979733517102 0.28023243812079 0.476745098858712 Decaprenylphosphoryl-D-2-keto erythro pentose reductase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3792 aftA 17.5 10.9 6.5 2.5 1.5 24.4996239953869 -1.84805860422484 0.686594829834206 -2.69162907135653 0.00711039787022052 0.0307885443231309 Arabinofuranosyltransferase AftA II.C.5 - Other membrane proteins Rv3793 embC 43.1 21.8 24.3 3.7 2.1 103.954851561225 -2.6197483950393 0.440091811221494 -5.95273151701704 2.63703706729705e-09 7.35463408847728e-08 Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3794 embA 38.2 20.3 16.3 8.7 0.6 86.0925014081612 -1.74385946341348 0.490884606391446 -3.55248349756332 0.000381612954379324 0.00277550941357611 Integral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3795 embB 61.1 36.3 28.1 7.5 2.4 143.872454313154 -2.33456786376532 0.363191130506044 -6.42793192805259 1.29351638510244e-10 4.72333508869367e-09 Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylindolylacetylinositol synthase) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3796 - 46.9 28.6 19.9 7.5 7 43.4185468883536 -1.41589752354948 0.567990229149514 -2.49282021218849 0.012673299924024 0.0482675573450461 hypothetical protein I.C.5 - Sulphur metabolism Rv3797 fadE35 28.1 31.6 11.2 8.1 2.4 48.7150317771242 -1.48111866550203 0.551412352687976 -2.6860454944145 0.00723032432188806 0.0312696077510714 Probable acyl-CoA dehydrogenase FadE35 I.A.3 - Fatty acids Rv3798 - 30.7 15.6 12.7 28.9 5.9 44.9411174607446 0.51929747508569 0.490855037325141 1.0579446793814 0.290080664024204 0.486029192040553 Probable transposase IV.B.1.c - Others Rv3799c accD4 762.9 427.4 393.5 437.4 148 1268.90581123132 -0.0731557472486911 0.230989541205108 -0.316705885760136 0.751466782341457 0.86982375430424 Probable propionyl-CoA carboxylase beta chain 4 AccD4 (pccase) (propanoyl-CoA:carbon dioxide ligase) I.H.1 - Synthesis of fatty and mycolic acids Rv3800c pks13 573 291.3 263.2 427 114.2 3226.08308494266 0.248973765485726 0.228712850875518 1.08858669083372 0.276336188490534 0.472157636099117 Polyketide synthase Pks13 I.I - Polyketide and non-ribosomal peptide synthesis Rv3801c fadD32 544.1 345.2 333.2 798.7 397.8 2112.76814341269 1.44672252718135 0.26447448329946 5.47017810237388 4.49583559274985e-08 9.62158970108042e-07 Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Also shown to have acyl-ACP ligase activity I.A.3 - Fatty acids Rv3802c - 234 157.5 115.7 252.8 120.6 382.510330713962 1.02735706939045 0.283158420466072 3.62820596222937 0.000285397546910771 0.00219279416737083 Probable conserved membrane protein VI - Unknowns Rv3803c fbpD 163.1 75.3 81 141.4 37.4 169.033239638266 0.474076591339543 0.322671701641662 1.46922270818165 0.141772392981945 0.29943817289329 Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) (85C) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3804c fbpA 1063.9 628.8 599.9 550.9 254 1214.19752340646 -0.0581316739317452 0.256686850776217 -0.226469231890749 0.820836487001112 0.905069083762199 Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) I.H.3 - Acyltransferases, Mycoloyltransferases, and phospholipid synthesis Rv3805c aftB 122.4 75.6 53.7 15.2 6 167.584012807027 -2.23750443528138 0.348466578074597 -6.42100154237 1.35380656424772e-10 4.89304372506678e-09 Possible arabinofuranosyltransferase AftB II.C.5 - Other membrane proteins Rv3806c ubiA 105.2 78 42.3 20.2 5.4 74.5539399214105 -1.77381358945728 0.447188562382585 -3.96658979828675 7.29083139767252e-05 0.00068499004802536 Decaprenylphosphoryl-5-phosphoribose (DPPR) synthase (decaprenyl-phosphate 5-phosphoribosyltransferase) II.C.5 - Other membrane proteins Rv3807c - 119.6 89.3 43.1 18.5 10.3 46.7231492928338 -1.82404933783146 0.545513481771308 -3.34372916304229 0.000826603924247546 0.00524700913922009 Possible conserved transmembrane protein II.C.5 - Other membrane proteins Rv3808c glfT2 170 111.2 82.6 62.3 28 316.97406175847 -0.592151246478517 0.28865026814422 -2.05144880095056 0.0402232607592997 0.11932226935464 Bifunctional UDP-galactofuranosyl transferase GlfT2 VI - Unknowns Rv3809c glf 54.8 31.8 23.9 51.9 16 82.622655621161 0.662574214231181 0.380725931505607 1.74029179365583 0.0818077942902842 0.201644542363387 UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) II.C.3 - Murein sacculus and peptidoglycan Rv3810 pirG 350.1 127.4 128.2 428.4 126.7 398.105169128923 1.25897013598834 0.292849083396301 4.29904072564444 1.71538952721081e-05 0.000206663595421112 Exported repetitive protein precursor PirG (cell surface protein) (EXP53) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3811 - 180.8 102.4 89.9 120.9 50.1 344.147953971799 0.286223022225749 0.274146617592919 1.04405089779646 0.29646184180103 0.492296223000116 hypothetical protein II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3812 PE_PGRS62 40 25.7 19.2 15 5.2 55.4365585032848 -0.758388944094358 0.453703844161455 -1.6715506246063 0.0946129680739663 0.225214471047035 PE-PGRS family protein PE_PGRS62 IV.C.1.b - PE_PGRS subfamily Rv3813c - 60.5 29.7 34.5 64.4 10 58.1586572236099 0.449354491180988 0.474292403864196 0.947420805224727 0.34342439361564 0.54487031010848 hypothetical protein V - Conserved hypotheticals Rv3814c - 66.9 28.5 29.2 68.4 29.4 72.49486525519 1.06673662942117 0.412917764693678 2.58341180891678 0.0097828474648682 0.0388462395970439 Possible acyltransferase IV.H - Miscellaneous transferases Rv3815c - 80.1 34.3 51.7 51 23.5 72.4225104004422 0.223332311247849 0.434901173106019 0.513524278752417 0.607584632036191 0.767777226974057 Possible acyltransferase IV.H - Miscellaneous transferases Rv3816c - 133 81.5 63.1 77 40 121.532973420124 0.192420486571644 0.359621629700461 0.535063718864508 0.592605796957524 0.758861074773517 Possible acyltransferase IV.H - Miscellaneous transferases Rv3817 - 17.3 17.2 7.7 13.4 7.8 19.8568933580532 0.458218788989502 0.700883083114701 0.653773503782105 0.513257739393459 0.697776102596014 Possible phosphotransferase IV.D - Antibiotic production and resistance Rv3818 - 76.3 62 36.9 71.2 25.9 168.339513031086 0.519378930648934 0.324420383331145 1.60094419874595 0.109389278944029 0.248369760269072 hypothetical protein VI - Unknowns Rv3819 - 43.4 45.3 34.1 33.9 0 17.1932260120263 -0.636216875694419 0.823013319834061 -0.773033510347919 0.43950254886437 0.633842845308469 hypothetical protein VI - Unknowns Rv3820c papA2 8.6 15.9 6.8 11.8 3.5 25.4541255245411 0.297686093422897 0.67100128379902 0.443644595935022 0.657299557903557 0.806706526020235 Possible conserved polyketide synthase associated protein PapA2 I.I - Polyketide and non-ribosomal peptide synthesis Rv3821 - 85.3 56.1 46.7 74.4 12.4 69.5810830167618 0.131217609203764 0.433820925251116 0.302469525018437 0.7622941616336 0.875802258232129 Probable conserved integral membrane protein V - Conserved hypotheticals Rv3822 - 332.1 315.1 214.8 178.4 108.1 560.924991384907 -0.09132871840276 0.323889572024297 -0.281974865173828 0.77796278328999 0.882621453687747 hypothetical protein V - Conserved hypotheticals Rv3823c mmpL8 137.4 120.3 82.8 28.7 5.7 411.824070328326 -2.09125997590515 0.321196123515788 -6.51085060745558 7.47264342411908e-11 2.87696771828584e-09 Conserved integral membrane transport protein MmpL8 II.C.4 - Conserved membrane proteins Rv3824c papA1 102.8 91.4 60.5 45.9 9.9 166.038000084763 -0.953357759252777 0.356291785252398 -2.67577810860112 0.00745559878736909 0.0320093707937713 Conserved polyketide synthase associated protein PapA1 I.I - Polyketide and non-ribosomal peptide synthesis Rv3825c pks2 166.4 113.6 79.5 186.1 29 1333.37099774308 0.38498846477285 0.299255308217416 1.28648834022736 0.198272685472605 0.375953882196985 Polyketide synthase Pks2 I.I - Polyketide and non-ribosomal peptide synthesis Rv3826 fadD23 49.9 49.1 28 35.1 9 110.018522584341 -0.249137638235941 0.384801913731314 -0.647443864870954 0.51734471421951 0.701544784749428 Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) I.A.3 - Fatty acids Rv3827c - 77.8 44.4 33.3 36.8 7.9 84.1752174516103 -0.471723976339252 0.398802473378935 -1.18285118029102 0.236868132684763 0.423089725652764 Possible transposase IV.B.1.c - Others Rv3828c - 31.2 29 11.8 27.2 11.3 25.8074175715096 0.421310722169439 0.618139108521268 0.681579140296287 0.495505108742328 0.683456496189807 Possible resolvase IV.B.1.c - Others Rv3829c - 9.2 2.7 4.8 3.1 0 9.84217636541594 -1.11259288185362 1.03777755893377 -1.07209186812318 0.283678770984308 0.480071766281136 Probable dehydrogenase I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3830c - 9.8 4.5 3.5 5.7 3.1 5.4326995038913 0.244451254092853 1.22252111577117 0.199956672272815 0.841514467250928 NA Transcriptional regulatory protein (probably TetR-family) I.J.1 - Repressors/activators Rv3831 - 10.4 7.5 6.7 6.1 7.4 8.54924901661509 0.641268927706341 1.04699139245987 0.612487296767268 0.540215400180148 0.719339453924092 Hypothetical protein VI - Unknowns Rv3832c - 4.1 0 0 6.6 0 1.77504757765591 1.86811782962798 2.32929664159436 0.802009411883792 0.422547513909029 NA hypothetical protein VI - Unknowns Rv3833 - 13.4 14 4.8 17.3 6.2 17.4036364862901 1.02206465393438 0.731299547856199 1.3976005549717 0.162233051618817 0.328359696476486 Transcriptional regulatory protein (probably AraC-family) I.J.1 - Repressors/activators Rv3834c serS 10.7 3.5 3.2 6.9 0 9.10082174925877 -0.0453813649205908 1.04155171645187 -0.0435709184707466 0.96524643337286 0.98505723293217 SERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase) II.A.3 - Aminoacyl tRNA synthases and their modification Rv3835 - 66.3 37.4 47.4 22.6 20.4 106.013777306175 -0.298793764281671 0.453435801171112 -0.658954946896475 0.50992469998336 0.694674341285023 hypothetical protein VI - Unknowns Rv3836 - 66.2 35.7 31.2 25.8 5.5 21.8574434620645 -0.886916717035678 0.688965155954355 -1.28731723131502 0.197983739985423 0.375607073930566 hypothetical protein VI - Unknowns Rv3837c - 195.6 110.2 97.6 150.1 67.9 175.862860074895 0.537745618060731 0.318791119778051 1.68682747008487 0.0916365317265525 0.219160429017859 Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) I.B.1 - Glycolysis Rv3838c pheA 76.6 36.5 35.4 51.3 19.4 80.5320326727982 0.282932837816656 0.390627821846378 0.724302832500049 0.468879838425757 0.660421053780088 Prephenate dehydratase PheA I.D.4 - Aromatic amino acid family Rv3839 - 4.3 0 1.5 2.7 0 1.68702001766958 0.362883821743489 2.21606322820791 0.163751564993454 0.869926722397773 NA hypothetical protein VI - Unknowns Rv3840 - 6.1 8.3 5.7 4.6 4.8 4.41885709448964 -0.0360650915843862 1.38485237464056 -0.0260425531593192 0.979223397435946 NA Possible transcriptional regulatory protein I.J.1 - Repressors/activators Rv3841 bfrB 14818.5 5482.3 4878.8 13225.1 5649.8 9905.3844788977 1.13624875102747 0.271450122998408 4.18584725059837 2.84104365259137e-05 0.000314875620260714 Bacterioferritin BfrB I.G.14 - Iron utilisation Rv3842c glpQ1 117.1 158.2 82.6 77.8 24.5 142.482926657893 -0.532354791046906 0.39996555828884 -1.33100158254741 0.183188490208403 0.355926293098279 Probable glycerophosphoryl diester phosphodiesterase GlpQ1 (glycerophosphodiester phosphodiesterase) I.C.1 - General Rv3843c - 137.6 95.6 68.4 121.9 32.5 177.285708298772 0.339240747801284 0.311624059552765 1.08862181016496 0.276320694832723 0.472157636099117 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3844 - 23.2 13.4 10.4 18 4.2 11.0701294263331 0.174436991197382 0.884173208675851 0.197288256967909 0.843601968337169 0.914892275520591 Possible transposase IV.B.1.c - Others Rv3845 - 11.7 9.2 10.7 1.5 0 3.90822850797424 -2.68230031841024 1.57824947304891 -1.69954139964229 0.089217221029626 NA Hypothetical protein VI - Unknowns Rv3846 sodA 117.2 100.6 59 162.5 101.4 158.430143975573 1.4612971365273 0.369563118884274 3.95412058686758 7.68166626430461e-05 0.000716012155478077 Superoxide dismutase [FE] SodA III.F - Detoxification Rv3847 - 175.5 116.4 59.5 130.4 74.1 123.620105314963 0.735749587831805 0.382241619451646 1.92482856494615 0.0542508091229382 0.148958423188719 Hypothetical protein VI - Unknowns Rv3848 - 145.7 55.5 83.3 131.8 64.5 185.23034588217 0.917678750474149 0.353861531495669 2.59332724468634 0.0095052279339143 0.0380854268573806 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3849 espR 400.8 379.2 194.5 238.8 58.8 181.340809612714 -0.44497717599623 0.349880012104224 -1.27179936150133 0.203444415896696 0.383094163267463 ESX-1 transcriptional regulatory protein EspR VI - Unknowns Rv3850 - 74.4 74.1 35.4 52.3 3 51.7081046935047 -0.608924210340899 0.576618183628763 -1.05602672206559 0.290956006560859 0.486804995389023 hypothetical protein VI - Unknowns Rv3851 - 22.9 11.3 14.2 6.4 3.4 4.82906755756988 -1.53902473153926 1.38847002128386 -1.10843209284143 0.267675251269299 NA Possible membrane protein VI - Unknowns Rv3852 hns 277.6 173.4 163 203.8 89.2 146.162948789576 0.316621602430006 0.334510150595593 0.946523152933517 0.343881818859094 0.54487031010848 Possible histone-like protein Hns II.A.4 - Nucleoproteins Rv3853 rraA 96.8 57.6 32.3 87 12.1 45.7388347833241 0.336493385982837 0.523938768582439 0.642237998331844 0.520718664488139 0.70315879131414 Regulator of RNase E activity a RraA I.G.11 - Menaquinone, PQQ, ubiquinone and other terpenoids Rv3854c ethA 542.8 409.6 256 739.2 242.6 1325.50114815506 1.05051518649914 0.241063671795814 4.35783284421616 1.31356643010153e-05 0.00016440467474981 Monooxygenase EthA I.B.7 - Miscellaneous oxidoreductases and oxygenases Rv3855 ethR 157.5 100 59.5 139.2 36.3 119.979876101807 0.496639077417473 0.350810462395507 1.41569060975598 0.15686610889104 0.321353243315247 Transcriptional regulatory repressor protein (TetR-family) EthR I.J.1 - Repressors/activators Rv3856c - 285.8 196.8 141.9 127.3 46.7 292.502253970326 -0.484370515653611 0.282257906509493 -1.71605650181254 0.0861517015423695 0.209436737723454 hypothetical protein V - Conserved hypotheticals Rv3857c - 600.4 304.5 302.9 285.2 120.7 119.525502770892 -0.18746779962282 0.354616166633965 -0.528649896033433 0.597048340423028 0.761247380049808 Possible membrane protein VI - Unknowns Rv3858c gltD 243.9 120.7 131.8 96 37.1 335.851992428094 -0.513129163285707 0.287491573867817 -1.78484940056586 0.0742857479129915 0.18595061421047 Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT) I.D.1 - Glutamate family Rv3859c gltB 251.2 141.7 138.1 174.4 51 1298.93669100193 0.069513228172436 0.235512170224294 0.295157690178957 0.767873421230677 0.878421529255059 Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH))(NADPH-GOGAT) I.D.1 - Glutamate family Rv3860 - 22.3 21.3 12.4 11.2 5.6 31.9257733051608 -0.428870654172693 0.579540055105774 -0.740019003681149 0.459288463384235 0.652503806127907 hypothetical protein V - Conserved hypotheticals Rv3861 - 5.3 0 2.6 0.5 4 1.95039078616076 0.368710916738557 2.2962586104047 0.160570292504456 0.872431854388043 NA Hypothetical protein VI - Unknowns Rv3862c whiB6 10 3.8 0 2.1 0 1.37094395391168 -0.686295205478197 2.41127110762306 -0.284619677691374 0.775935533911531 NA Possible transcriptional regulatory protein WhiB-like WhiB6 VI - Unknowns Rv3863 - 55.7 43.1 27.3 39.8 21.5 90.3777788111612 0.389584944900564 0.398382137542229 0.977917703097989 0.328115028653437 0.528605826962998 Unknown alanine rich protein VI - Unknowns Rv3864 espE 270.8 184.9 161.5 373.7 185 640.383016015246 1.32143227219958 0.277101945551561 4.7687585504653 1.85364663175558e-06 2.86708138413897e-05 ESX-1 secretion-associated protein EspE V - Conserved hypotheticals Rv3865 espF 546.5 435.8 416 876.3 375 365.58974378617 1.20666934667358 0.300929936455511 4.00980161989292 6.07697820851406e-05 0.000589716625056351 ESX-1 secretion-associated protein EspF V - Conserved hypotheticals Rv3866 espG1 244.6 139.8 157 268.5 92.5 312.600356232437 0.744864778218906 0.286322060657084 2.60149279629207 0.00928190144751236 0.037342459803427 ESX-1 secretion-associated protein EspG1 V - Conserved hypotheticals Rv3867 espH 386.1 182.3 222.2 479.2 178 336.428972283536 1.1124148316793 0.288014529534935 3.86235664386635 0.000112298464064315 0.00100191727888112 ESX-1 secretion-associated protein EspH V - Conserved hypotheticals Rv3868 eccA1 344.6 195.6 218.7 285.6 117 809.027266028694 0.47908660092042 0.265681331074808 1.80323773214431 0.0713508870239603 0.180553524556688 ESX conserved component EccA1 ESX-1 type VII secretion system protein V - Conserved hypotheticals Rv3869 eccB1 787.7 542.3 456.7 300.6 139.3 1191.97627347411 -0.587799386208034 0.2584070121094 -2.27470369867201 0.0229237104705586 0.077255739759009 ESX conserved component EccB1 ESX-1 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv3870 eccCa1 973.5 674.7 537.4 445.6 164.9 2309.14571129553 -0.46840371652846 0.230055684825991 -2.0360449553018 0.0417458412707059 0.122201462628794 ESX conserved component EccCa1 ESX-1 type VII secretion system protein Possible transmembrane protein V - Conserved hypotheticals Rv3871 eccCb1 648.5 443 299 284.7 68.3 1077.91215628951 -0.712989981625172 0.252339959603669 -2.82551357599094 0.00472048875880566 0.0217707958120959 ESX conserved component EccCb1 ESX-1 type VII secretion system protein V - Conserved hypotheticals Rv3872 PE35 715 498 383.6 314 135.4 228.075924632967 -0.442324488669463 0.304758161613556 -1.45139505477903 0.146669885991179 0.305628951189143 PE family-related protein PE35 IV.C.1.a - PE subfamily Rv3873 PPE68 627.1 365.4 307.1 250.4 95.3 659.046411749575 -0.512576356533901 0.248288903367649 -2.06443521873756 0.0389764701365048 0.116501820441772 PPE family protein PPE68 IV.C.2 - PPE family Rv3874 esxB 6111.3 5590.3 5007.5 4111.7 3826.4 3389.64561916417 0.58860377121358 0.369150468244966 1.5944819845738 0.110828122633483 0.250832722279742 10 kDa culture filtrate antigen EsxB (LHP) (CFP10) V - Conserved hypotheticals Rv3875 esxA 4119.9 2561 1881.1 3833.4 1600.7 1652.25781155849 0.794512543692776 0.237669854615329 3.3429251891398 0.000829002457551877 0.00525282058076699 6 kDa early secretory antigenic target EsxA (ESAT-6) II.C.2 - Surface polysaccharides, lipopolysaccharides, proteins and antigens Rv3876 espI 133.4 88.3 66.1 130.3 80.2 445.55189033027 1.10961207310529 0.308479008779966 3.59704239680296 0.000321856038996799 0.00240002966342455 ESX-1 secretion-associated protein EspI Conserved proline and alanine rich protein V - Conserved hypotheticals Rv3877 eccD1 191 78.2 69.3 196.9 61.9 362.986927362734 1.01161614513094 0.285025326242588 3.54921493632443 0.000386381559874113 0.00280366963056016 ESX conserved component EccD1 ESX-1 type VII secretion system protein Probable transmembrane protein V - Conserved hypotheticals Rv3878 espJ 436.6 286.9 208.5 240.3 100.9 407.332644438062 -0.0377405916032698 0.26988624630202 -0.139838884420348 0.888787289803759 0.943105027107524 ESX-1 secretion-associated protein EspJ Conserved alanine rich protein VI - Unknowns Rv3879c espK 220.7 158.2 127.9 140.4 54.4 590.662086978939 -0.0104114551652216 0.258105218956704 -0.0403380265122344 0.967823637664732 0.986483834419707 ESX-1 secretion-associated protein EspK Alanine and proline rich protein VI - Unknowns Rv3880c espL 255 180.1 149.3 308.8 128.6 149.888085914966 0.961834430381845 0.328039484112244 2.93206908608825 0.00336711834578288 0.0166336585505759 ESX-1 secretion-associated protein EspL V - Conserved hypotheticals Rv3881c espB 379.7 304.5 223.9 349.3 164.5 820.445017321652 0.616914068576081 0.272786311586413 2.26152868517618 0.0237265384661888 0.0792418664353221 Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein V - Conserved hypotheticals Rv3882c eccE1 117.1 51.6 51.6 22.8 9.8 117.991314573591 -1.38705531788673 0.377554537965752 -3.67378796546885 0.00023898106777116 0.00189367101128736 ESX conserved component EccE1 ESX-1 type VII secretion system protein Possible membrane protein V - Conserved hypotheticals Rv3883c mycP1 169.7 84.3 77.9 49.8 20.6 189.410629348719 -0.841511524156861 0.319878138907578 -2.63072533506267 0.00852028650868231 0.0352969062149155 Membrane-anchored mycosin MycP1 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-1) II.B.3 - Proteins, peptides and glycopeptides Rv3884c eccA2 83.6 51.4 54.7 14.6 6.6 135.758305980451 -1.85755340657261 0.377858721804353 -4.91599981522833 8.83304804645912e-07 1.48984077050277e-05 ESX conserved component EccA2 ESX-2 type VII secretion system protein Probable CbxX/CfqX family protein V - Conserved hypotheticals Rv3885c eccE2 63.3 44.1 26.8 10.8 3.6 79.2136546390943 -1.8485778719542 0.431014461383799 -4.28889988057296 1.79560285509281e-05 0.000212668197852107 ESX conserved component EccE2 ESX-2 type VII secretion system protein Possible membrane protein VI - Unknowns Rv3886c mycP2 39.7 17.8 16.9 4.2 4.4 47.1136519853324 -1.75634395270578 0.584762433012518 -3.0035170755714 0.00266878572205309 0.0140249837203443 Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2) II.B.3 - Proteins, peptides and glycopeptides Rv3887c eccD2 37.5 19 23.9 13.7 4.5 52.6534342563728 -0.881731536019363 0.479380747226628 -1.83931361682851 0.0658690713726014 0.170671726994699 ESX conserved component EccD2 ESX-2 type VII secretion system protein Probable transmembrane protein II.C.5 - Other membrane proteins Rv3888c - 71.7 50.6 40.4 40.8 28 98.5667895382061 0.236095770568991 0.410359320713378 0.57533912025821 0.565061968965053 0.737725578353932 Probable conserved membrane protein V - Conserved hypotheticals Rv3889c espG2 25.2 12.3 14.2 9.6 3.6 18.3571502851423 -0.700497568595813 0.720612423564481 -0.972086444375784 0.331007545305044 0.530991270593507 ESX-2 secretion-associated protein EspG2 VI - Unknowns Rv3890c esxC 132.4 142.4 58.9 83 61.4 56.6450184628694 0.250063833579819 0.510116115121645 0.490209632997357 0.623985564958979 0.780974159393888 ESAT-6 like protein EsxC (ESAT-6 like protein 11) VI - Unknowns Rv3891c esxD 106.4 53.5 81.9 86.8 37.1 47.8500338882541 0.370583301481399 0.498239654626994 0.743785240777023 0.457006410587451 0.650871212827001 Possible ESAT-6 like protein EsxD VI - Unknowns Rv3892c PPE69 9.8 6.5 4.8 1.9 1.6 9.78738134785333 -1.56349967703096 1.00721353818805 -1.55230208664952 0.120589958882807 0.267290134144495 PPE family protein PPE69 IV.C.2 - PPE family Rv3893c PE36 93.7 77.3 31.6 29.7 5.4 17.9237650306905 -1.14494062061598 0.765382623316411 -1.4959062117911 0.13467809734662 0.288061485991382 PE family protein PE36 IV.C.1.a - PE subfamily Rv3894c eccC2 45.6 33.9 23.1 17.9 4.2 181.122417993925 -0.909440113269664 0.328526769282559 -2.76823747195917 0.0056360372331771 0.0253335582232402 ESX conserved component EccC2 ESX-2 type VII secretion system protein Possible membrane protein II.C.5 - Other membrane proteins Rv3895c eccB2 22.5 16.6 8.2 15 3.8 34.1973858598865 -0.0173989944767955 0.550870670917998 -0.0315845358907944 0.974803375809182 0.99017882337715 ESX conserved component EccB2 ESX-2 type VII secretion system protein Probable membrane protein V - Conserved hypotheticals Rv3896c - 54.8 35.9 27.1 38.9 4.7 49.4221939386029 -0.212415881424547 0.510013177220431 -0.416490967120129 0.67705077580346 0.820502818639317 hypothetical protein IV.A - Virulence Rv3897c - 60.9 33.8 32.8 39.3 6.8 37.4884988931658 -0.217925163754028 0.541842817694795 -0.402192585446023 0.687542298539095 0.827240874741502 hypothetical protein V - Conserved hypotheticals Rv3898c - 99.1 73.4 39.1 72.5 28.6 40.1537303919079 0.339670108363596 0.508226962009231 0.668343346092344 0.503914450275096 0.688605317466971 hypothetical protein V - Conserved hypotheticals Rv3899c - 23.1 9.7 13.6 5.6 1.7 21.4025002089508 -1.47146715014825 0.718918640662297 -2.04677840707076 0.0406798467095557 0.120173492114467 hypothetical protein V - Conserved hypotheticals Rv3900c - 81.9 35.3 45.7 31.2 14.1 71.4588423084893 -0.468733610484086 0.435468072480294 -1.07639030300045 0.281752737332961 0.478641820447649 Conserved hypothetical alanine rich protein V - Conserved hypotheticals Rv3901c - 22.6 11.4 23.1 6.3 1 9.58626262150326 -1.92009558810054 1.10305093998585 -1.74071343262276 0.0817338225295644 0.201644542363387 Possible membrane protein II.C.5 - Other membrane proteins Rv3902c - 34.1 10.3 9.8 35.7 14.8 22.3796335127025 1.28098966921919 0.662790978148647 1.93272043744068 0.0532706461283521 0.14706518206284 Hypothetical protein VI - Unknowns Rv3903c - 12.4 8.1 6.9 6.8 1.8 31.4724198837454 -0.410681679979809 0.566715115795915 -0.724670418227742 0.468654247166691 0.660421053780088 Hypothetical alanine and proline rich protein VI - Unknowns Rv3904c esxE 21.1 21.3 13.8 5 0 4.97052609442747 -1.99737712589301 1.3902435850723 -1.43671019045856 0.150800358195259 NA Putative ESAT-6 like protein EsxE (hypothetical alanine rich protein) (ESAT-6 like protein 12) VI - Unknowns Rv3905c esxF 15.5 10.9 9.4 6.5 0 3.9933985481773 -1.03742481453089 1.47782745208623 -0.701993194852598 0.48268340737171 NA Putative ESAT-6 like protein EsxF (hypothetical alanine and glycine rich protein) (ESAT-6 like protein 13) VI - Unknowns Rv3906c - 104.3 34.2 60.4 69.8 22.4 54.9807801629511 0.209286121051663 0.480771802323112 0.435312803372374 0.663335392734017 0.811587316217242 hypothetical protein V - Conserved hypotheticals Rv3907c pcnA 54.5 34.4 32.6 34.2 7.9 84.6965206484522 -0.270469953378682 0.397810907891063 -0.67989576960707 0.496570460452247 0.683846256190458 Probable poly(A) polymerase PcnA (polynucleotide adenylyltransferase) (NTP polymerase) (RNA adenylating enzyme) (poly(A) polymerase) II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3908 mutT4 70.4 48.7 30.7 30.1 13.3 52.6676546396716 -0.415780307831013 0.465844415579374 -0.892530411283141 0.37210869984008 0.57379582709341 Possible mutator protein MutT4 V - Conserved hypotheticals Rv3909 - 61.2 32.8 30.8 27.7 6.5 133.38747721922 -0.559050739039277 0.347108334724488 -1.61059439694243 0.10726815585588 0.244336854045999 hypothetical protein V - Conserved hypotheticals Rv3910 - 95.4 62 38.8 26.7 7.3 274.511436021212 -1.20070960287017 0.301872836115903 -3.97753444238077 6.9633539031146e-05 0.000659470575530265 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3911 sigM 21.2 14.2 14.1 4.2 2.2 12.6634917933567 -1.77603293514001 0.907773732111938 -1.95647094899745 0.0504097014341324 0.140892068046728 Possible alternative RNA polymerase sigma factor SigM II.A.7 - RNA synthesis, RNA modification and DNA transcription Rv3912 - 11.5 4 3.4 5.7 3.9 8.27166009336943 0.340092091543011 1.01933979436901 0.333639570849417 0.738651554359396 0.860909445719309 Hypothetical alanine rich protein VI - Unknowns Rv3913 trxB2 45.6 20 29.2 50.3 38.7 90.2601304422944 1.47784513505778 0.449801720375159 3.2855479828427 0.0010178420461082 0.00625902174881118 Probable thioredoxin reductase TrxB2 (TRXR) (TR) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv3914 trxC 100.4 34.7 59.7 113 92.8 69.6329891010014 1.65953962054867 0.494018494142149 3.35926618178621 0.000781497530569919 0.00499650587234414 Thioredoxin TrxC (TRX) (MPT46) I.G.10 - Thioredoxin, glutaredoxin and mycothiol Rv3915 - 202.5 106.3 80 232.7 52.9 312.393528118887 0.848508411812897 0.289888816898319 2.9270132628487 0.00342234285990091 0.0168555928835658 Probable peptidoglycan hydrolase II.B.4 - Polysaccharides, lipopolysaccharides and phospholipids Rv3916c - 164.5 75.3 51.3 203.8 36.3 143.244116180449 1.00213368525135 0.37215912497871 2.69275591538613 0.00708641272049566 0.0307598944313672 hypothetical protein V - Conserved hypotheticals Rv3917c parB 275.7 199.9 126.7 122 33.3 276.202581584278 -0.636369158037423 0.294626154225777 -2.15992079762804 0.0307788014419772 0.0968192848201451 Probable chromosome partitioning protein ParB III.C - Cell division Rv3918c parA 169.2 150.3 75.6 32.7 6.2 147.942804772172 -2.05087266866809 0.399895325495673 -5.12852373587017 2.92023084094324e-07 5.27727430541885e-06 Probable chromosome partitioning protein ParA III.C - Cell division Rv3919c gid 176.9 196.7 148.6 34.6 14.2 136.634184130006 -2.15852129310168 0.417720440867467 -5.16738249298778 2.3739512294345e-07 4.44896045219947e-06 Probable glucose-inhibited division protein B Gid III.C - Cell division Rv3920c - 440.6 364.2 260.2 156.4 47.3 252.32662038258 -1.09502516434243 0.309249355830981 -3.54091332348938 0.000398744547167295 0.00287648306734534 Conserved protein similar to jag protein V - Conserved hypotheticals Rv3921c - 440.7 391.3 254.3 268.4 99.2 607.207133299131 -0.216278554166255 0.274229902334649 -0.78867604271078 0.430301373662647 0.624898509845467 Probable conserved transmembrane protein II.C.5 - Other membrane proteins Rv3922c - 291.3 252.5 126.2 306.2 113.8 158.830558572442 0.702181194096571 0.339467000988988 2.06848144900938 0.0385947732568152 0.11565371140071 Possible hemolysin IV.A - Virulence Rv3923c rnpA 243 173.3 158.3 380.4 138 177.081519418743 1.1952561363654 0.316907638106767 3.7716229987575 0.000162189176104104 0.00135601710426296 Ribonuclease P protein component RnpA (RNaseP protein) (RNase P protein) (protein C5) II.B.1 - RNA Rv3924c rpmH 264.6 155.8 78.8 773.4 114.2 76.6102661126134 2.06598124365111 0.454271835510579 4.5478963962823 5.41847967206818e-06 7.52637450920215e-05 50S ribosomal protein L34 RpmH II.A.1 - Ribosomal protein synthesis and modification