TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3770A/-:
none

Correlation of Rv3770A/- with Rv3770A/-

Normalized LFCs for Rv3770A/-:
(description and provenance of datasets)

	Rv3770A/-	Rv3770A/-
Fe_supp_jason_reseq	-2.153	-2.153
low_pH_jason_reseq	0.964	0.964
NO_jason_reseq	-0.074	-0.074
B6_jason_reseq	-3.075	-3.075
MHCII_jason_reseq	-1.826	-1.826
Isoniazid02	-0.109	-0.109
Rifampicin4	-1.486	-1.486
Ethambutol3	-0.803	-0.803
Meropenem3	0.337	0.337
Vancomycin16	-1.6	-1.6
Rv2680_day32	-1.545	-1.545
H37Rv_KO_MarP	1.264	1.264
hypoxia_3wks	0.383	0.383
hypoxia_6wks	0.297	0.297
glycerol	1.043	1.043
cholesterol	-3.135	-3.135
AJ	-2.469	-2.469
Bibs02	-2.285	-2.285
Bibs02c	-2.439	-2.439
BL6	-0.832	-0.832
BL6a	-1.636	-1.636
BXD01	-2.732	-2.732
BXD010	-2.387	-2.387
BXD011	-1.926	-1.926
BXD03	-3.129	-3.129
BXD04	-2.441	-2.441
BXD05	-3.01	-3.01
BXD06	-0.589	-0.589
BXD07	-0.727	-0.727
BXD08	-1.623	-1.623
BXD09	-0.935	-0.935
CAST	0.137	0.137
CCcont	-1.483	-1.483
DS01	-1.61	-1.61
DS02	-0.561	-0.561
DS04	-3.164	-3.164
DS0c	-1.046	-1.046
GP01	-1.457	-1.457
GP02	-1.801	-1.801
GP0c	0.614	0.614
NOD	-0.338	-0.338
NZO	-1.428	-1.428
PWK	-1.404	-1.404
H37Rv_KO_CtpC	-1.938	-1.938
H37Rv_KO_CtpD	-2.576	-2.576
H37Rv_KO_Rv1272	-3.263	-3.263
H37Rv_KO_SugABC	0.219	0.219
H37Rv_KO_MbtN	1.028	1.028
Trans05	-1.005	-1.005
macrophage_unactivated	-1.215	-1.215
IL1	-0.756	-0.756
Rapamycin	-1.396	-1.396
Tcell	-1.971	-1.971
GMCSF	-1.811	-1.811
IFNab	0.339	0.339
IFNg	0.136	0.136
IFNg_GMCSF1	2.011	2.011
Rv1432_day32	-0.705	-0.705
Rv1565c_day32	0.0	0.0
secA2_input	-1.639	-1.639
delta_Rv3594	-0.104	-0.104
delta_Rv3717	1.062	1.062
delta_Rv3811	-0.971	-0.971
delta_Rv0954	-0.749	-0.749
PonA1	0.619	0.619
EccD1_KO	0.802	0.802
EspI_KO	0.533	0.533
PE35_KO	-1.321	-1.321
PPE68_KO	-0.368	-0.368
glycerol2	-1.77	-1.77
lignocerate	0.072	0.072
oleate	-1.791	-1.791
phosphatidylcholine	-0.95	-0.95
acetate	1.225	1.225
glucAc	0.061	0.061
Rv0950ko	-1.833	-1.833
Rv1096ko	-1.191	-1.191
Rv3684ko	-1.526	-1.526
delta_otsA_trehalose	1.507	1.507