TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3252c/alkB:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation. none

Correlation of Rv3252c/alkB with Rv3252c/alkB

Normalized LFCs for Rv3252c/alkB:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv3252c/alkB	Rv3252c/alkB
Fe_supp_jason_reseq	-0.139	-0.139
low_pH_jason_reseq	-0.32	-0.32
NO_jason_reseq	-0.063	-0.063
B6_jason_reseq	-0.569	-0.569
MHCII_jason_reseq	0.247	0.247
Isoniazid02	-0.701	-0.701
Rifampicin4	0.298	0.298
Ethambutol3	-0.328	-0.328
Meropenem3	-0.229	-0.229
Vancomycin16	-0.287	-0.287
Rv2680_day32	-0.311	-0.311
H37Rv_KO_MarP	0.134	0.134
hypoxia_3wks	-0.084	-0.084
hypoxia_6wks	0.205	0.205
glycerol	-0.124	-0.124
cholesterol	-0.653	-0.653
AJ	-0.247	-0.247
Bibs02	0.155	0.155
Bibs02c	0.468	0.468
BL6	0.41	0.41
BL6a	0.547	0.547
BXD01	0.534	0.534
BXD010	0.356	0.356
BXD011	0.711	0.711
BXD03	0.569	0.569
BXD04	0.686	0.686
BXD05	0.45	0.45
BXD06	0.672	0.672
BXD07	0.673	0.673
BXD08	0.522	0.522
BXD09	0.451	0.451
CAST	0.255	0.255
CCcont	0.215	0.215
DS01	-0.327	-0.327
DS02	0.027	0.027
DS04	-0.254	-0.254
DS0c	-0.171	-0.171
GP01	0.61	0.61
GP02	0.928	0.928
GP0c	0.114	0.114
NOD	0.415	0.415
NZO	0.384	0.384
PWK	0.212	0.212
H37Rv_KO_CtpC	0.514	0.514
H37Rv_KO_CtpD	0.645	0.645
H37Rv_KO_Rv1272	0.323	0.323
H37Rv_KO_SugABC	0.7	0.7
H37Rv_KO_MbtN	0.013	0.013
Trans05	0.504	0.504
macrophage_unactivated	0.511	0.511
IL1	0.172	0.172
Rapamycin	-0.037	-0.037
Tcell	0.443	0.443
GMCSF	0.275	0.275
IFNab	0.0	0.0
IFNg	0.267	0.267
IFNg_GMCSF1	0.302	0.302
Rv1432_day32	-0.059	-0.059
Rv1565c_day32	0.074	0.074
secA2_input	0.51	0.51
delta_Rv3594	-0.294	-0.294
delta_Rv3717	-0.361	-0.361
delta_Rv3811	-0.175	-0.175
delta_Rv0954	0.101	0.101
PonA1	-0.178	-0.178
EccD1_KO	0.0	0.0
EspI_KO	-0.328	-0.328
PE35_KO	-0.271	-0.271
PPE68_KO	-0.525	-0.525
glycerol2	0.769	0.769
lignocerate	0.424	0.424
oleate	0.58	0.58
phosphatidylcholine	0.592	0.592
acetate	-0.364	-0.364
glucAc	-0.314	-0.314
Rv0950ko	0.202	0.202
Rv1096ko	-0.1	-0.1
Rv3684ko	0.835	0.835
delta_otsA_trehalose	0.57	0.57