TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3206c/moeB1:

update plot	correlation	link to info on gene
Rv1638/uvrA	(cc=0.4533)	info on Rv1638/uvrA
Rv0819/mshD	(cc=0.4428)	info on Rv0819/mshD
Rv0179c/lprO	(cc=0.4401)	info on Rv0179c/lprO
Rv3232c/ppk2	(cc=0.4164)	info on Rv3232c/ppk2
Rv3433c/-	(cc=0.4145)	info on Rv3433c/-
Rv3269/-	(cc=0.4116)	info on Rv3269/-
Rv3417c/groEL1	(cc=0.4095)	info on Rv3417c/groEL1
Rv1748/-	(cc=0.409)	info on Rv1748/-
Rv0805/-	(cc=0.4041)	info on Rv0805/-
Rv1665/pks11	(cc=0.3996)	info on Rv1665/pks11

Correlation of Rv3206c/moeB1 with Rv3417c/groEL1

Normalized LFCs for Rv3206c/moeB1:
(description and provenance of datasets)

	Rv3206c/moeB1	Rv3417c/groEL1
Fe_supp_jason_reseq	0.688	1.528
low_pH_jason_reseq	-0.303	0.0
NO_jason_reseq	-1.016	0.16
B6_jason_reseq	0.413	0.133
MHCII_jason_reseq	-0.085	0.631
Isoniazid02	1.736	0.585
Rifampicin4	-0.769	0.523
Ethambutol3	0.34	0.946
Meropenem3	-0.128	0.839
Vancomycin16	-0.284	0.936
Rv2680_day32	1.001	0.632
H37Rv_KO_MarP	0.505	0.432
hypoxia_3wks	0.187	1.156
hypoxia_6wks	-0.8	-0.867
glycerol	-0.471	1.24
cholesterol	0.435	0.68
AJ	0.442	1.76
Bibs02	1.507	0.183
Bibs02c	1.516	1.325
BL6	0.084	-0.091
BL6a	0.696	1.291
BXD01	1.031	0.582
BXD010	0.316	0.762
BXD011	0.83	0.383
BXD03	0.091	0.604
BXD04	0.434	0.465
BXD05	0.661	-0.314
BXD06	0.535	0.627
BXD07	1.05	-0.1
BXD08	0.765	0.292
BXD09	0.863	0.916
CAST	-0.537	-0.082
CCcont	0.917	1.662
DS01	0.31	2.091
DS02	0.285	2.113
DS04	1.036	1.228
DS0c	1.332	1.534
GP01	-0.147	0.188
GP02	0.409	0.479
GP0c	0.17	0.17
NOD	-0.727	1.38
NZO	0.493	1.706
PWK	-0.293	0.831
H37Rv_KO_CtpC	0.401	-1.294
H37Rv_KO_CtpD	0.166	2.216
H37Rv_KO_Rv1272	0.185	1.29
H37Rv_KO_SugABC	1.82	1.777
H37Rv_KO_MbtN	0.506	0.196
Trans05	0.249	-1.041
macrophage_unactivated	0.234	-0.328
IL1	-0.736	-3.275
Rapamycin	-0.491	-1.307
Tcell	-0.254	-2.74
GMCSF	0.0	-1.125
IFNab	1.019	0.828
IFNg	0.198	-1.021
IFNg_GMCSF1	-0.245	-0.804
Rv1432_day32	-0.494	-0.391
Rv1565c_day32	-0.182	1.655
secA2_input	0.938	0.283
delta_Rv3594	0.26	0.45
delta_Rv3717	-0.424	0.058
delta_Rv3811	0.33	0.409
delta_Rv0954	1.708	1.085
PonA1	-0.145	-0.027
EccD1_KO	-0.595	0.0
EspI_KO	0.456	-0.528
PE35_KO	0.89	0.295
PPE68_KO	0.134	0.323
glycerol2	-0.297	-0.262
lignocerate	-0.794	-1.173
oleate	0.6	0.155
phosphatidylcholine	0.298	-1.183
acetate	-1.084	-0.871
glucAc	-0.785	-1.156
Rv0950ko	0.669	-0.145
Rv1096ko	-0.92	0.093
Rv3684ko	0.327	-0.052
delta_otsA_trehalose	0.321	0.861