TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3206c/moeB1:

update plot	correlation	link to info on gene
Rv1638/uvrA	(cc=0.4533)	info on Rv1638/uvrA
Rv0819/mshD	(cc=0.4428)	info on Rv0819/mshD
Rv0179c/lprO	(cc=0.4401)	info on Rv0179c/lprO
Rv3232c/ppk2	(cc=0.4164)	info on Rv3232c/ppk2
Rv3433c/-	(cc=0.4145)	info on Rv3433c/-
Rv3269/-	(cc=0.4116)	info on Rv3269/-
Rv3417c/groEL1	(cc=0.4095)	info on Rv3417c/groEL1
Rv1748/-	(cc=0.409)	info on Rv1748/-
Rv0805/-	(cc=0.4041)	info on Rv0805/-
Rv1665/pks11	(cc=0.3996)	info on Rv1665/pks11

Correlation of Rv3206c/moeB1 with Rv3269/-

Normalized LFCs for Rv3206c/moeB1:
(description and provenance of datasets)

	Rv3206c/moeB1	Rv3269/-
Fe_supp_jason_reseq	0.688	2.502
low_pH_jason_reseq	-0.303	-0.811
NO_jason_reseq	-1.016	-1.273
B6_jason_reseq	0.413	-0.119
MHCII_jason_reseq	-0.085	0.189
Isoniazid02	1.736	1.759
Rifampicin4	-0.769	-0.523
Ethambutol3	0.34	-0.399
Meropenem3	-0.128	-0.648
Vancomycin16	-0.284	-1.995
Rv2680_day32	1.001	0.0
H37Rv_KO_MarP	0.505	-1.411
hypoxia_3wks	0.187	-3.218
hypoxia_6wks	-0.8	-1.815
glycerol	-0.471	0.0
cholesterol	0.435	2.81
AJ	0.442	1.425
Bibs02	1.507	0.183
Bibs02c	1.516	0.0
BL6	0.084	0.125
BL6a	0.696	1.897
BXD01	1.031	1.247
BXD010	0.316	0.128
BXD011	0.83	0.987
BXD03	0.091	0.475
BXD04	0.434	0.0
BXD05	0.661	0.135
BXD06	0.535	0.366
BXD07	1.05	0.851
BXD08	0.765	0.133
BXD09	0.863	0.943
CAST	-0.537	0.439
CCcont	0.917	3.546
DS01	0.31	1.451
DS02	0.285	0.0
DS04	1.036	0.822
DS0c	1.332	0.0
GP01	-0.147	0.0
GP02	0.409	0.0
GP0c	0.17	0.0
NOD	-0.727	0.0
NZO	0.493	0.701
PWK	-0.293	0.374
H37Rv_KO_CtpC	0.401	2.984
H37Rv_KO_CtpD	0.166	0.537
H37Rv_KO_Rv1272	0.185	0.141
H37Rv_KO_SugABC	1.82	1.066
H37Rv_KO_MbtN	0.506	1.109
Trans05	0.249	0.249
macrophage_unactivated	0.234	-0.275
IL1	-0.736	-1.863
Rapamycin	-0.491	-1.188
Tcell	-0.254	-1.639
GMCSF	0.0	-1.328
IFNab	1.019	-0.547
IFNg	0.198	-1.034
IFNg_GMCSF1	-0.245	-2.407
Rv1432_day32	-0.494	0.0
Rv1565c_day32	-0.182	1.895
secA2_input	0.938	-1.691
delta_Rv3594	0.26	2.951
delta_Rv3717	-0.424	2.246
delta_Rv3811	0.33	2.342
delta_Rv0954	1.708	0.391
PonA1	-0.145	1.1
EccD1_KO	-0.595	-1.825
EspI_KO	0.456	-0.75
PE35_KO	0.89	0.548
PPE68_KO	0.134	-0.618
glycerol2	-0.297	-1.6
lignocerate	-0.794	-1.529
oleate	0.6	-1.187
phosphatidylcholine	0.298	-2.094
acetate	-1.084	-1.034
glucAc	-0.785	-0.899
Rv0950ko	0.669	0.862
Rv1096ko	-0.92	-1.559
Rv3684ko	0.327	0.0
delta_otsA_trehalose	0.321	-0.204