TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3206c/moeB1:

update plot	correlation	link to info on gene
Rv1638/uvrA	(cc=0.4533)	info on Rv1638/uvrA
Rv0819/mshD	(cc=0.4428)	info on Rv0819/mshD
Rv0179c/lprO	(cc=0.4401)	info on Rv0179c/lprO
Rv3232c/ppk2	(cc=0.4164)	info on Rv3232c/ppk2
Rv3433c/-	(cc=0.4145)	info on Rv3433c/-
Rv3269/-	(cc=0.4116)	info on Rv3269/-
Rv3417c/groEL1	(cc=0.4095)	info on Rv3417c/groEL1
Rv1748/-	(cc=0.409)	info on Rv1748/-
Rv0805/-	(cc=0.4041)	info on Rv0805/-
Rv1665/pks11	(cc=0.3996)	info on Rv1665/pks11

Correlation of Rv3206c/moeB1 with Rv0819/mshD

Normalized LFCs for Rv3206c/moeB1:
(description and provenance of datasets)

	Rv3206c/moeB1	Rv0819/mshD
Fe_supp_jason_reseq	0.688	2.234
low_pH_jason_reseq	-0.303	0.219
NO_jason_reseq	-1.016	-1.536
B6_jason_reseq	0.413	0.461
MHCII_jason_reseq	-0.085	-0.789
Isoniazid02	1.736	4.505
Rifampicin4	-0.769	0.655
Ethambutol3	0.34	1.105
Meropenem3	-0.128	-0.999
Vancomycin16	-0.284	0.355
Rv2680_day32	1.001	3.755
H37Rv_KO_MarP	0.505	-0.872
hypoxia_3wks	0.187	-2.831
hypoxia_6wks	-0.8	-0.232
glycerol	-0.471	0.424
cholesterol	0.435	1.943
AJ	0.442	0.373
Bibs02	1.507	0.294
Bibs02c	1.516	1.576
BL6	0.084	-0.425
BL6a	0.696	1.254
BXD01	1.031	1.185
BXD010	0.316	1.0
BXD011	0.83	0.847
BXD03	0.091	1.472
BXD04	0.434	1.095
BXD05	0.661	0.895
BXD06	0.535	1.397
BXD07	1.05	0.587
BXD08	0.765	0.564
BXD09	0.863	2.443
CAST	-0.537	0.692
CCcont	0.917	2.248
DS01	0.31	0.811
DS02	0.285	-0.922
DS04	1.036	0.498
DS0c	1.332	-1.116
GP01	-0.147	0.561
GP02	0.409	0.627
GP0c	0.17	0.551
NOD	-0.727	-1.155
NZO	0.493	-0.525
PWK	-0.293	-0.666
H37Rv_KO_CtpC	0.401	0.179
H37Rv_KO_CtpD	0.166	1.023
H37Rv_KO_Rv1272	0.185	0.938
H37Rv_KO_SugABC	1.82	2.66
H37Rv_KO_MbtN	0.506	-0.127
Trans05	0.249	0.503
macrophage_unactivated	0.234	-1.496
IL1	-0.736	-1.649
Rapamycin	-0.491	-1.215
Tcell	-0.254	-0.391
GMCSF	0.0	-2.49
IFNab	1.019	0.795
IFNg	0.198	-1.97
IFNg_GMCSF1	-0.245	-0.578
Rv1432_day32	-0.494	0.0
Rv1565c_day32	-0.182	-0.218
secA2_input	0.938	0.064
delta_Rv3594	0.26	1.508
delta_Rv3717	-0.424	1.464
delta_Rv3811	0.33	1.591
delta_Rv0954	1.708	0.68
PonA1	-0.145	-0.291
EccD1_KO	-0.595	-2.259
EspI_KO	0.456	-0.901
PE35_KO	0.89	1.622
PPE68_KO	0.134	1.001
glycerol2	-0.297	-2.128
lignocerate	-0.794	-1.972
oleate	0.6	-1.839
phosphatidylcholine	0.298	-2.196
acetate	-1.084	-0.028
glucAc	-0.785	-0.562
Rv0950ko	0.669	-1.402
Rv1096ko	-0.92	2.31
Rv3684ko	0.327	0.593
delta_otsA_trehalose	0.321	-0.867