TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3206c/moeB1:

update plot	correlation	link to info on gene
Rv1638/uvrA	(cc=0.4533)	info on Rv1638/uvrA
Rv0819/mshD	(cc=0.4428)	info on Rv0819/mshD
Rv0179c/lprO	(cc=0.4401)	info on Rv0179c/lprO
Rv3232c/ppk2	(cc=0.4164)	info on Rv3232c/ppk2
Rv3433c/-	(cc=0.4145)	info on Rv3433c/-
Rv3269/-	(cc=0.4116)	info on Rv3269/-
Rv3417c/groEL1	(cc=0.4095)	info on Rv3417c/groEL1
Rv1748/-	(cc=0.409)	info on Rv1748/-
Rv0805/-	(cc=0.4041)	info on Rv0805/-
Rv1665/pks11	(cc=0.3996)	info on Rv1665/pks11

Correlation of Rv3206c/moeB1 with Rv1638/uvrA

Normalized LFCs for Rv3206c/moeB1:
(description and provenance of datasets)

	Rv3206c/moeB1	Rv1638/uvrA
Fe_supp_jason_reseq	0.688	2.005
low_pH_jason_reseq	-0.303	-0.842
NO_jason_reseq	-1.016	-0.874
B6_jason_reseq	0.413	-1.019
MHCII_jason_reseq	-0.085	-1.251
Isoniazid02	1.736	-0.061
Rifampicin4	-0.769	-1.11
Ethambutol3	0.34	0.542
Meropenem3	-0.128	-0.628
Vancomycin16	-0.284	-0.764
Rv2680_day32	1.001	0.0
H37Rv_KO_MarP	0.505	-0.563
hypoxia_3wks	0.187	-1.204
hypoxia_6wks	-0.8	-1.817
glycerol	-0.471	1.654
cholesterol	0.435	0.773
AJ	0.442	-0.242
Bibs02	1.507	-0.294
Bibs02c	1.516	0.382
BL6	0.084	0.63
BL6a	0.696	0.997
BXD01	1.031	0.486
BXD010	0.316	-0.206
BXD011	0.83	0.475
BXD03	0.091	0.189
BXD04	0.434	0.372
BXD05	0.661	0.3
BXD06	0.535	0.498
BXD07	1.05	0.194
BXD08	0.765	0.297
BXD09	0.863	0.572
CAST	-0.537	-0.809
CCcont	0.917	2.708
DS01	0.31	-0.12
DS02	0.285	0.0
DS04	1.036	0.094
DS0c	1.332	0.652
GP01	-0.147	-0.28
GP02	0.409	0.339
GP0c	0.17	0.942
NOD	-0.727	-1.126
NZO	0.493	-0.701
PWK	-0.293	-0.433
H37Rv_KO_CtpC	0.401	1.331
H37Rv_KO_CtpD	0.166	0.558
H37Rv_KO_Rv1272	0.185	0.71
H37Rv_KO_SugABC	1.82	1.472
H37Rv_KO_MbtN	0.506	1.713
Trans05	0.249	0.344
macrophage_unactivated	0.234	1.382
IL1	-0.736	-0.436
Rapamycin	-0.491	-0.295
Tcell	-0.254	0.0
GMCSF	0.0	-0.671
IFNab	1.019	0.771
IFNg	0.198	-0.679
IFNg_GMCSF1	-0.245	-0.625
Rv1432_day32	-0.494	-1.562
Rv1565c_day32	-0.182	-0.269
secA2_input	0.938	0.783
delta_Rv3594	0.26	0.39
delta_Rv3717	-0.424	-0.415
delta_Rv3811	0.33	0.095
delta_Rv0954	1.708	0.499
PonA1	-0.145	-0.504
EccD1_KO	-0.595	0.329
EspI_KO	0.456	-0.128
PE35_KO	0.89	0.817
PPE68_KO	0.134	1.161
glycerol2	-0.297	-1.562
lignocerate	-0.794	-1.816
oleate	0.6	-1.904
phosphatidylcholine	0.298	-2.088
acetate	-1.084	-0.143
glucAc	-0.785	0.356
Rv0950ko	0.669	-0.302
Rv1096ko	-0.92	-0.663
Rv3684ko	0.327	-0.72
delta_otsA_trehalose	0.321	0.081