TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3196/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2076c/-	(cc=0.6525)	info on Rv2076c/-
Rv3295/-	(cc=0.6419)	info on Rv3295/-
Rv0379/secE2	(cc=0.6375)	info on Rv0379/secE2
Rv1323/fadA4	(cc=0.6357)	info on Rv1323/fadA4
Rv3354/-	(cc=0.6226)	info on Rv3354/-
Rv2681/-	(cc=0.6173)	info on Rv2681/-
Rv1974/-	(cc=0.5914)	info on Rv1974/-
Rv0008c/-	(cc=0.591)	info on Rv0008c/-
Rv1834/lipZ	(cc=0.5865)	info on Rv1834/lipZ
Rv2872/vapC43	(cc=0.5857)	info on Rv2872/vapC43

Correlation of Rv3196/- with Rv2076c/-

Normalized LFCs for Rv3196/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv3196/-	Rv2076c/-
Fe_supp_jason_reseq	0.182	0.305
low_pH_jason_reseq	-1.014	-2.265
NO_jason_reseq	0.937	0.567
B6_jason_reseq	0.371	1.5
MHCII_jason_reseq	0.676	1.645
Isoniazid02	1.017	2.357
Rifampicin4	-0.179	0.834
Ethambutol3	0.238	0.362
Meropenem3	0.262	0.175
Vancomycin16	-0.297	0.417
Rv2680_day32	-1.033	0.027
H37Rv_KO_MarP	0.437	-0.444
hypoxia_3wks	-0.618	-0.582
hypoxia_6wks	-0.426	-0.787
glycerol	0.399	-0.467
cholesterol	0.242	-0.256
AJ	-0.195	0.03
Bibs02	0.507	-0.197
Bibs02c	-0.023	0.441
BL6	-0.425	-0.961
BL6a	-1.076	-0.502
BXD01	-0.504	-0.752
BXD010	-1.253	-2.255
BXD011	-0.267	-0.622
BXD03	-0.799	-0.844
BXD04	-1.527	-1.482
BXD05	-1.121	-0.751
BXD06	-0.7	-1.283
BXD07	-0.961	-1.076
BXD08	-1.099	-0.99
BXD09	-1.533	-1.085
CAST	0.417	0.184
CCcont	-0.53	-1.147
DS01	0.269	0.657
DS02	-0.164	0.399
DS04	0.347	0.582
DS0c	0.332	1.012
GP01	0.206	-0.398
GP02	-1.388	-1.033
GP0c	-1.051	-0.616
NOD	-0.103	-0.5
NZO	-0.266	-0.777
PWK	-0.318	-0.108
H37Rv_KO_CtpC	-1.181	-1.97
H37Rv_KO_CtpD	0.988	0.54
H37Rv_KO_Rv1272	0.011	-0.487
H37Rv_KO_SugABC	-0.154	-0.265
H37Rv_KO_MbtN	-1.502	0.274
Trans05	-0.68	-2.138
macrophage_unactivated	-0.521	0.224
IL1	-0.249	0.288
Rapamycin	-0.338	0.055
Tcell	-0.316	-0.567
GMCSF	-0.951	-0.224
IFNab	-0.499	-0.623
IFNg	-0.206	1.753
IFNg_GMCSF1	-0.814	-0.39
Rv1432_day32	0.345	0.304
Rv1565c_day32	1.488	0.461
secA2_input	0.546	0.185
delta_Rv3594	0.647	0.359
delta_Rv3717	-0.814	1.125
delta_Rv3811	0.077	1.087
delta_Rv0954	0.567	0.258
PonA1	-0.127	0.703
EccD1_KO	0.069	0.687
EspI_KO	0.833	-0.1
PE35_KO	-0.125	0.779
PPE68_KO	-0.256	0.371
glycerol2	0.765	0.94
lignocerate	1.058	1.515
oleate	0.262	0.116
phosphatidylcholine	0.658	1.237
acetate	0.569	1.639
glucAc	1.645	1.644
Rv0950ko	0.338	0.814
Rv1096ko	1.019	-0.133
Rv3684ko	0.416	-0.386
delta_otsA_trehalose	-0.251	-0.252