TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2910c/-:

update plot	correlation	link to info on gene
Rv2340c/PE_PGRS39	(cc=0.4796)	info on Rv2340c/PE_PGRS39
Rv1378c/-	(cc=0.4735)	info on Rv1378c/-
Rv1145/mmpL13a	(cc=0.4587)	info on Rv1145/mmpL13a
Rv2920c/amt	(cc=0.4539)	info on Rv2920c/amt
Rv1192/-	(cc=0.4341)	info on Rv1192/-
Rv2478c/-	(cc=0.4301)	info on Rv2478c/-
Rv0840c/pip	(cc=0.4281)	info on Rv0840c/pip
Rv1140/-	(cc=0.4225)	info on Rv1140/-
Rv3482c/-	(cc=0.4182)	info on Rv3482c/-
Rv1453/-	(cc=0.414)	info on Rv1453/-

Correlation of Rv2910c/- with Rv1192/-

Normalized LFCs for Rv2910c/-:
(description and provenance of datasets)

	Rv2910c/-	Rv1192/-
Fe_supp_jason_reseq	0.275	1.031
low_pH_jason_reseq	-0.967	-1.225
NO_jason_reseq	0.137	-0.189
B6_jason_reseq	0.127	1.83
MHCII_jason_reseq	1.187	1.815
Isoniazid02	0.841	0.377
Rifampicin4	0.203	-0.125
Ethambutol3	0.951	1.46
Meropenem3	1.054	1.205
Vancomycin16	0.761	0.119
Rv2680_day32	-0.397	1.037
H37Rv_KO_MarP	1.229	0.203
hypoxia_3wks	0.738	-0.861
hypoxia_6wks	-0.66	-1.207
glycerol	-0.434	-1.119
cholesterol	0.521	-0.023
AJ	-0.039	0.266
Bibs02	0.931	0.485
Bibs02c	1.206	0.377
BL6	-0.485	-0.701
BL6a	0.367	-0.218
BXD01	0.121	-0.434
BXD010	-0.096	-1.013
BXD011	-0.555	-0.527
BXD03	0.373	-0.481
BXD04	1.308	-0.115
BXD05	-1.224	-1.431
BXD06	-0.172	-0.467
BXD07	-0.784	-0.623
BXD08	-0.564	-0.793
BXD09	-0.169	-0.899
CAST	0.018	0.469
CCcont	0.024	-0.592
DS01	0.469	1.167
DS02	1.204	0.429
DS04	0.278	1.526
DS0c	0.25	0.947
GP01	-1.505	-0.602
GP02	-0.46	0.033
GP0c	-0.229	-1.353
NOD	-0.417	0.731
NZO	0.5	0.025
PWK	0.695	0.374
H37Rv_KO_CtpC	-1.19	-0.644
H37Rv_KO_CtpD	0.533	-0.502
H37Rv_KO_Rv1272	-0.144	-0.653
H37Rv_KO_SugABC	-0.174	-0.293
H37Rv_KO_MbtN	0.902	-1.325
Trans05	-0.979	-0.495
macrophage_unactivated	-0.139	0.092
IL1	-0.602	-0.329
Rapamycin	-0.135	-1.04
Tcell	0.046	0.248
GMCSF	-0.364	-0.465
IFNab	-0.986	-0.305
IFNg	-1.392	-0.81
IFNg_GMCSF1	-0.434	-0.418
Rv1432_day32	-0.464	-0.92
Rv1565c_day32	-0.019	-0.573
secA2_input	0.131	-0.177
delta_Rv3594	-0.22	0.659
delta_Rv3717	-0.011	0.02
delta_Rv3811	-0.14	0.946
delta_Rv0954	0.158	1.187
PonA1	-0.286	0.372
EccD1_KO	-0.691	-0.957
EspI_KO	-0.288	-0.2
PE35_KO	0.306	-0.277
PPE68_KO	-0.25	-0.035
glycerol2	0.188	0.935
lignocerate	0.045	1.103
oleate	-0.394	0.669
phosphatidylcholine	-0.027	1.139
acetate	0.293	0.618
glucAc	-0.09	0.666
Rv0950ko	0.259	0.648
Rv1096ko	-0.926	0.682
Rv3684ko	-0.065	0.383
delta_otsA_trehalose	-0.447	-0.476