TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2882c/frr:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv3673c/-	(cc=0.8128)	info on Rv3673c/-
Rv0701/rplC	(cc=0.7923)	info on Rv0701/rplC
Rv2678c/hemE	(cc=0.7708)	info on Rv2678c/hemE
Rv3489/-	(cc=0.6548)	info on Rv3489/-
Rv3670/ephE	(cc=0.651)	info on Rv3670/ephE
Rv2373c/dnaJ2	(cc=0.6505)	info on Rv2373c/dnaJ2
Rv3025c/iscS	(cc=0.6463)	info on Rv3025c/iscS
Rv3858c/gltD	(cc=0.6352)	info on Rv3858c/gltD
Rv3753c/-	(cc=0.6341)	info on Rv3753c/-
Rv0637/hadC	(cc=0.5599)	info on Rv0637/hadC

Correlation of Rv2882c/frr with Rv3673c/-

Normalized LFCs for Rv2882c/frr:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2882c/frr	Rv3673c/-
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.201	0.0
Rifampicin4	0.341	0.0
Ethambutol3	0.293	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.923	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	0.371	0.0
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	-0.202	0.0
cholesterol	-0.145	0.0
AJ	0.212	0.0
Bibs02	-0.183	0.0
Bibs02c	0.527	0.0
BL6	-0.125	0.0
BL6a	-0.198	0.0
BXD01	-0.13	0.0
BXD010	-0.128	0.0
BXD011	-0.127	0.0
BXD03	0.0	0.0
BXD04	-0.124	0.0
BXD05	-0.135	0.0
BXD06	0.762	0.0
BXD07	-0.138	0.0
BXD08	-0.133	0.0
BXD09	-0.14	0.0
CAST	-0.23	0.0
CCcont	-0.149	0.0
DS01	-0.236	0.0
DS02	-0.217	0.0
DS04	-0.194	0.0
DS0c	0.0	0.0
GP01	-0.099	0.0
GP02	-0.083	0.0
GP0c	-0.13	0.0
NOD	-0.225	0.0
NZO	0.182	0.0
PWK	1.009	0.0
H37Rv_KO_CtpC	-0.162	0.0
H37Rv_KO_CtpD	-0.127	0.0
H37Rv_KO_Rv1272	-0.141	0.0
H37Rv_KO_SugABC	-0.099	0.0
H37Rv_KO_MbtN	-0.103	0.0
Trans05	-0.131	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.568	0.593
delta_Rv3594	-0.176	0.0
delta_Rv3717	-0.477	0.0
delta_Rv3811	-0.564	0.0
delta_Rv0954	-0.49	0.0
PonA1	-0.437	0.0
EccD1_KO	-2.519	-1.595
EspI_KO	-2.185	-1.383
PE35_KO	-2.234	-1.415
PPE68_KO	-2.451	-0.71
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	1.462	0.0
Rv1096ko	1.143	0.0
Rv3684ko	0.0	0.0
delta_otsA_trehalose	0.0	0.0