TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2878c/mpt53:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv0575c/-	(cc=0.4208)	info on Rv0575c/-
Rv0179c/lprO	(cc=0.4191)	info on Rv0179c/lprO
Rv0111/-	(cc=0.4065)	info on Rv0111/-
Rv0972c/fadE12	(cc=0.3975)	info on Rv0972c/fadE12
Rv3810/pirG	(cc=0.3886)	info on Rv3810/pirG
Rv0203/-	(cc=0.3836)	info on Rv0203/-
Rv0999/-	(cc=0.3765)	info on Rv0999/-
Rv2073c/-	(cc=0.3698)	info on Rv2073c/-
Rv2590/fadD9	(cc=0.3667)	info on Rv2590/fadD9
Rv2521/bcp	(cc=0.3645)	info on Rv2521/bcp

Correlation of Rv2878c/mpt53 with Rv0575c/-

Normalized LFCs for Rv2878c/mpt53:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2878c/mpt53	Rv0575c/-
Fe_supp_jason_reseq	-0.191	-0.022
low_pH_jason_reseq	-0.666	-0.652
NO_jason_reseq	0.677	0.247
B6_jason_reseq	0.032	-0.269
MHCII_jason_reseq	-0.256	0.348
Isoniazid02	1.166	1.046
Rifampicin4	-1.765	0.076
Ethambutol3	-0.197	0.592
Meropenem3	-0.304	-0.077
Vancomycin16	-0.814	-0.029
Rv2680_day32	-0.258	-0.104
H37Rv_KO_MarP	0.313	0.539
hypoxia_3wks	-0.068	-0.096
hypoxia_6wks	0.524	-0.338
glycerol	1.355	-0.69
cholesterol	1.535	-0.599
AJ	-0.649	-0.701
Bibs02	0.456	-1.062
Bibs02c	-1.334	-0.211
BL6	-0.426	-0.718
BL6a	-0.11	-0.379
BXD01	-0.695	0.084
BXD010	-0.314	-0.044
BXD011	-0.213	0.573
BXD03	0.471	-0.07
BXD04	-0.149	-0.274
BXD05	0.205	0.087
BXD06	0.053	-0.103
BXD07	-0.254	-0.3
BXD08	-0.42	0.613
BXD09	0.025	-0.18
CAST	0.0	-0.274
CCcont	-1.269	-0.804
DS01	0.197	-0.585
DS02	0.287	-0.362
DS04	-0.498	-0.977
DS0c	0.501	0.42
GP01	1.142	0.227
GP02	0.33	0.979
GP0c	0.357	0.247
NOD	-0.628	-0.957
NZO	-0.409	-0.191
PWK	-0.918	-0.774
H37Rv_KO_CtpC	-0.627	0.02
H37Rv_KO_CtpD	1.391	1.102
H37Rv_KO_Rv1272	0.676	0.223
H37Rv_KO_SugABC	0.822	0.446
H37Rv_KO_MbtN	-1.281	-0.458
Trans05	-0.018	0.235
macrophage_unactivated	0.388	-0.066
IL1	0.169	0.276
Rapamycin	-0.436	-0.086
Tcell	-0.508	0.241
GMCSF	-0.451	-0.092
IFNab	0.115	-0.021
IFNg	0.168	-0.131
IFNg_GMCSF1	-0.145	0.716
Rv1432_day32	0.568	-0.643
Rv1565c_day32	-1.047	-0.024
secA2_input	0.034	0.446
delta_Rv3594	0.719	0.162
delta_Rv3717	-0.14	0.048
delta_Rv3811	1.117	-0.028
delta_Rv0954	0.375	0.286
PonA1	-0.509	-0.337
EccD1_KO	-0.707	0.217
EspI_KO	0.231	0.262
PE35_KO	-0.627	0.096
PPE68_KO	-0.419	0.128
glycerol2	0.318	-0.256
lignocerate	-0.958	0.084
oleate	0.475	0.542
phosphatidylcholine	-0.193	0.242
acetate	-1.172	-0.73
glucAc	-0.452	-0.916
Rv0950ko	0.739	0.359
Rv1096ko	0.618	0.519
Rv3684ko	1.166	0.367
delta_otsA_trehalose	-2.398	-1.789