TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2706c/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation. none

Correlation of Rv2706c/- with Rv2706c/-

Normalized LFCs for Rv2706c/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2706c/-	Rv2706c/-
Fe_supp_jason_reseq	1.006	1.006
low_pH_jason_reseq	2.789	2.789
NO_jason_reseq	3.035	3.035
B6_jason_reseq	0.1	0.1
MHCII_jason_reseq	-1.821	-1.821
Isoniazid02	-1.766	-1.766
Rifampicin4	1.887	1.887
Ethambutol3	-0.837	-0.837
Meropenem3	-1.756	-1.756
Vancomycin16	0.493	0.493
Rv2680_day32	-0.818	-0.818
H37Rv_KO_MarP	-1.008	-1.008
hypoxia_3wks	-1.212	-1.212
hypoxia_6wks	0.09	0.09
glycerol	-0.525	-0.525
cholesterol	-2.016	-2.016
AJ	-1.462	-1.462
Bibs02	-3.613	-3.613
Bibs02c	-2.574	-2.574
BL6	-0.093	-0.093
BL6a	0.773	0.773
BXD01	-1.547	-1.547
BXD010	1.252	1.252
BXD011	0.936	0.936
BXD03	1.289	1.289
BXD04	0.0	0.0
BXD05	0.614	0.614
BXD06	1.023	1.023
BXD07	0.13	0.13
BXD08	-0.167	-0.167
BXD09	0.592	0.592
CAST	0.189	0.189
CCcont	-1.601	-1.601
DS01	-1.518	-1.518
DS02	0.769	0.769
DS04	-2.798	-2.798
DS0c	0.757	0.757
GP01	-1.909	-1.909
GP02	0.828	0.828
GP0c	-0.501	-0.501
NOD	-1.993	-1.993
NZO	-0.946	-0.946
PWK	0.243	0.243
H37Rv_KO_CtpC	3.322	3.322
H37Rv_KO_CtpD	-0.829	-0.829
H37Rv_KO_Rv1272	0.989	0.989
H37Rv_KO_SugABC	0.905	0.905
H37Rv_KO_MbtN	2.999	2.999
Trans05	-2.64	-2.64
macrophage_unactivated	0.275	0.275
IL1	-0.047	-0.047
Rapamycin	0.221	0.221
Tcell	0.31	0.31
GMCSF	1.196	1.196
IFNab	-1.188	-1.188
IFNg	2.045	2.045
IFNg_GMCSF1	1.153	1.153
Rv1432_day32	-0.171	-0.171
Rv1565c_day32	-1.605	-1.605
secA2_input	-0.266	-0.266
delta_Rv3594	-1.066	-1.066
delta_Rv3717	2.134	2.134
delta_Rv3811	1.133	1.133
delta_Rv0954	-1.613	-1.613
PonA1	-2.44	-2.44
EccD1_KO	0.168	0.168
EspI_KO	-1.574	-1.574
PE35_KO	-1.19	-1.19
PPE68_KO	0.118	0.118
glycerol2	4.178	4.178
lignocerate	3.899	3.899
oleate	2.836	2.836
phosphatidylcholine	3.084	3.084
acetate	0.0	0.0
glucAc	2.029	2.029
Rv0950ko	0.096	0.096
Rv1096ko	-2.054	-2.054
Rv3684ko	-0.475	-0.475
delta_otsA_trehalose	-0.21	-0.21