TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2644c/-:

update plot	correlation	link to info on gene
Rv3081/-	(cc=0.5601)	info on Rv3081/-
Rv1156/-	(cc=0.5382)	info on Rv1156/-
Rv0740/-	(cc=0.5214)	info on Rv0740/-
Rv1574/-	(cc=0.5195)	info on Rv1574/-
Rv0378/-	(cc=0.5177)	info on Rv0378/-
Rv1439c/-	(cc=0.5163)	info on Rv1439c/-
Rv0327c/cyp135A1	(cc=0.5009)	info on Rv0327c/cyp135A1
Rv2426c/-	(cc=0.4974)	info on Rv2426c/-
Rv1289/-	(cc=0.4964)	info on Rv1289/-
Rv2402/-	(cc=0.4819)	info on Rv2402/-

Correlation of Rv2644c/- with Rv3081/-

Normalized LFCs for Rv2644c/-:
(description and provenance of datasets)

	Rv2644c/-	Rv3081/-
Fe_supp_jason_reseq	1.624	0.111
low_pH_jason_reseq	0.99	0.338
NO_jason_reseq	0.793	-0.614
B6_jason_reseq	0.809	0.927
MHCII_jason_reseq	1.643	-0.023
Isoniazid02	-0.351	-0.493
Rifampicin4	0.493	0.853
Ethambutol3	1.667	0.1
Meropenem3	-0.121	0.973
Vancomycin16	0.284	0.382
Rv2680_day32	-1.817	-0.806
H37Rv_KO_MarP	-0.107	0.652
hypoxia_3wks	-1.18	-0.526
hypoxia_6wks	-0.593	-0.779
glycerol	-1.912	-0.724
cholesterol	-0.064	-0.663
AJ	0.175	-0.76
Bibs02	-0.132	0.232
Bibs02c	0.158	0.047
BL6	0.83	-1.009
BL6a	-0.607	-0.588
BXD01	0.05	-1.148
BXD010	-0.647	-1.706
BXD011	-0.616	-0.826
BXD03	-0.702	-0.849
BXD04	-0.772	0.194
BXD05	-0.605	-0.379
BXD06	-0.213	-0.457
BXD07	-1.09	-0.61
BXD08	-1.085	-1.44
BXD09	-0.398	-0.669
CAST	0.923	-0.304
CCcont	-0.194	-0.968
DS01	0.467	0.69
DS02	1.115	-0.232
DS04	1.488	1.827
DS0c	0.925	0.828
GP01	-0.32	0.652
GP02	-0.753	0.983
GP0c	-0.075	-0.075
NOD	0.958	0.171
NZO	0.769	-0.477
PWK	0.402	0.021
H37Rv_KO_CtpC	-1.404	-1.759
H37Rv_KO_CtpD	0.175	-0.028
H37Rv_KO_Rv1272	-1.232	-0.646
H37Rv_KO_SugABC	-2.224	-1.012
H37Rv_KO_MbtN	-0.234	-1.022
Trans05	-1.029	-0.428
macrophage_unactivated	0.297	-0.767
IL1	-0.205	-0.721
Rapamycin	-0.276	0.077
Tcell	-0.394	-0.251
GMCSF	0.525	-0.721
IFNab	0.0	-0.154
IFNg	0.0	0.318
IFNg_GMCSF1	0.38	0.374
Rv1432_day32	-0.541	-0.164
Rv1565c_day32	-0.818	0.54
secA2_input	-1.288	-0.404
delta_Rv3594	-2.276	-1.1
delta_Rv3717	-1.793	-0.905
delta_Rv3811	-1.728	-1.069
delta_Rv0954	-1.593	-1.222
PonA1	-1.322	-1.175
EccD1_KO	0.829	0.678
EspI_KO	-0.148	0.231
PE35_KO	-0.05	0.671
PPE68_KO	0.71	0.506
glycerol2	0.336	0.478
lignocerate	1.37	1.0
oleate	-1.799	-0.634
phosphatidylcholine	0.623	0.864
acetate	1.12	1.026
glucAc	1.148	0.957
Rv0950ko	0.911	0.078
Rv1096ko	-0.368	0.311
Rv3684ko	-0.521	1.294
delta_otsA_trehalose	-0.11	-0.405