TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2633c/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv3295/-	(cc=0.8202)	info on Rv3295/-
Rv3059/cyp136	(cc=0.7624)	info on Rv3059/cyp136
Rv0228/-	(cc=0.7434)	info on Rv0228/-
Rv0758/phoR	(cc=0.7415)	info on Rv0758/phoR
Rv2499c/-	(cc=0.7387)	info on Rv2499c/-
Rv3354/-	(cc=0.726)	info on Rv3354/-
Rv1974/-	(cc=0.692)	info on Rv1974/-
Rv3395c/-	(cc=0.6905)	info on Rv3395c/-
Rv0089/-	(cc=0.6866)	info on Rv0089/-
Rv0850/-	(cc=0.6767)	info on Rv0850/-

Correlation of Rv2633c/- with Rv3295/-

Normalized LFCs for Rv2633c/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2633c/-	Rv3295/-
Fe_supp_jason_reseq	-0.311	-0.311
low_pH_jason_reseq	-1.37	-1.467
NO_jason_reseq	1.982	0.399
B6_jason_reseq	2.097	1.709
MHCII_jason_reseq	2.688	2.745
Isoniazid02	-1.835	-0.08
Rifampicin4	0.788	-0.736
Ethambutol3	-1.015	-0.766
Meropenem3	1.543	1.594
Vancomycin16	0.992	-2.144
Rv2680_day32	-1.492	-0.028
H37Rv_KO_MarP	-0.251	0.872
hypoxia_3wks	-1.635	0.04
hypoxia_6wks	-0.935	0.069
glycerol	-3.439	-1.066
cholesterol	-1.698	-0.911
AJ	-1.847	-0.094
Bibs02	-2.015	-0.197
Bibs02c	-1.479	-0.488
BL6	-4.097	-1.617
BL6a	-2.705	-1.21
BXD01	-3.305	-2.04
BXD010	-2.545	-1.261
BXD011	-3.454	-1.45
BXD03	-4.022	-1.975
BXD04	-3.05	-1.206
BXD05	-3.466	-1.799
BXD06	-3.175	-1.84
BXD07	-3.925	-1.907
BXD08	-3.425	-2.202
BXD09	-3.938	-1.692
CAST	-1.121	-0.377
CCcont	-3.226	-2.55
DS01	-2.479	-0.573
DS02	-2.478	-0.243
DS04	-1.739	-1.214
DS0c	-3.309	-0.159
GP01	-2.635	-0.495
GP02	-2.268	-1.862
GP0c	-3.348	-3.192
NOD	-0.823	0.265
NZO	-1.331	0.438
PWK	-1.07	-0.034
H37Rv_KO_CtpC	-4.742	-1.189
H37Rv_KO_CtpD	-1.586	-0.309
H37Rv_KO_Rv1272	-3.011	-0.822
H37Rv_KO_SugABC	-1.628	-1.536
H37Rv_KO_MbtN	-2.419	-2.764
Trans05	-2.951	-1.09
macrophage_unactivated	-5.293	-3.033
IL1	-4.974	-2.637
Rapamycin	-5.146	-2.998
Tcell	-4.558	-2.77
GMCSF	-4.605	-2.389
IFNab	-6.0	-4.099
IFNg	-4.145	-1.86
IFNg_GMCSF1	-4.452	-1.555
Rv1432_day32	-1.082	0.528
Rv1565c_day32	-0.234	1.414
secA2_input	-0.355	0.819
delta_Rv3594	0.136	-0.159
delta_Rv3717	-1.179	-0.35
delta_Rv3811	-0.013	-0.437
delta_Rv0954	0.286	-0.012
PonA1	0.524	0.697
EccD1_KO	-0.987	-0.536
EspI_KO	-0.337	-0.442
PE35_KO	0.435	-0.096
PPE68_KO	0.701	0.067
glycerol2	2.304	2.42
lignocerate	2.288	1.125
oleate	1.324	-0.113
phosphatidylcholine	6.0	2.459
acetate	1.057	0.436
glucAc	0.245	0.323
Rv0950ko	-1.291	1.019
Rv1096ko	-1.846	0.338
Rv3684ko	-0.55	0.907
delta_otsA_trehalose	-0.497	0.261