TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2386c/mbtI:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2383c/mbtB	(cc=0.7913)	info on Rv2383c/mbtB
Rv2384/mbtA	(cc=0.7739)	info on Rv2384/mbtA
Rv2379c/mbtF	(cc=0.7404)	info on Rv2379c/mbtF
Rv2380c/mbtE	(cc=0.7261)	info on Rv2380c/mbtE
Rv2381c/mbtD	(cc=0.615)	info on Rv2381c/mbtD
Rv2378c/mbtG	(cc=0.5209)	info on Rv2378c/mbtG
Rv0470c/pcaA	(cc=0.5176)	info on Rv0470c/pcaA
Rv2382c/mbtC	(cc=0.5046)	info on Rv2382c/mbtC
Rv1592c/-	(cc=0.4891)	info on Rv1592c/-
Rv0681/-	(cc=0.4791)	info on Rv0681/-

Correlation of Rv2386c/mbtI with Rv2383c/mbtB

Normalized LFCs for Rv2386c/mbtI:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2386c/mbtI	Rv2383c/mbtB
Fe_supp_jason_reseq	0.508	1.163
low_pH_jason_reseq	0.979	1.506
NO_jason_reseq	-1.63	-0.541
B6_jason_reseq	-1.11	-0.649
MHCII_jason_reseq	-0.977	-0.572
Isoniazid02	-2.781	-0.076
Rifampicin4	0.72	0.512
Ethambutol3	-1.699	0.458
Meropenem3	-2.059	-0.612
Vancomycin16	-0.631	-0.207
Rv2680_day32	-1.705	-1.693
H37Rv_KO_MarP	0.502	1.146
hypoxia_3wks	-2.504	-2.759
hypoxia_6wks	-1.311	-2.234
glycerol	-0.094	1.271
cholesterol	-0.985	0.8
AJ	-0.595	-1.037
Bibs02	-0.694	-1.09
Bibs02c	-1.423	-1.423
BL6	-1.089	-1.089
BL6a	-1.027	-1.181
BXD01	-1.004	-1.004
BXD010	-0.987	-1.115
BXD011	-0.982	-1.109
BXD03	-1.177	-1.177
BXD04	-0.953	-0.953
BXD05	-1.172	-1.172
BXD06	-0.597	-0.796
BXD07	-1.206	-1.206
BXD08	-1.025	-1.158
BXD09	-1.083	-1.224
CAST	0.0	0.102
CCcont	0.0	-0.219
DS01	2.488	2.917
DS02	1.369	1.141
DS04	0.469	0.964
DS0c	-0.556	-0.101
GP01	-0.672	-0.761
GP02	-0.724	-0.724
GP0c	-1.132	-1.002
NOD	0.543	0.195
NZO	-0.292	-0.757
PWK	-0.745	-0.745
H37Rv_KO_CtpC	-1.105	-0.075
H37Rv_KO_CtpD	-0.657	-0.4
H37Rv_KO_Rv1272	-1.228	-1.228
H37Rv_KO_SugABC	-0.763	-0.674
H37Rv_KO_MbtN	-0.614	-0.614
Trans05	-1.007	-1.138
macrophage_unactivated	1.846	1.098
IL1	-0.374	0.0
Rapamycin	0.0	0.0
Tcell	3.06	2.809
GMCSF	-0.333	0.0
IFNab	-0.795	-0.417
IFNg	-0.337	-0.369
IFNg_GMCSF1	0.0	0.757
Rv1432_day32	0.0	-0.343
Rv1565c_day32	-0.599	1.3
secA2_input	1.169	1.586
delta_Rv3594	-1.19	-1.432
delta_Rv3717	-0.424	-1.178
delta_Rv3811	-1.008	-1.392
delta_Rv0954	-0.435	-0.087
PonA1	0.72	0.624
EccD1_KO	2.042	1.875
EspI_KO	0.981	0.582
PE35_KO	1.368	2.226
PPE68_KO	0.506	2.188
glycerol2	-1.24	-0.779
lignocerate	-0.505	-0.577
oleate	-1.418	-0.457
phosphatidylcholine	-0.819	-0.451
acetate	-0.56	0.185
glucAc	0.429	-0.49
Rv0950ko	0.172	-0.109
Rv1096ko	-0.76	0.208
Rv3684ko	-0.393	0.0
delta_otsA_trehalose	0.744	-0.539