TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2378c/mbtG:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2380c/mbtE	(cc=0.784)	info on Rv2380c/mbtE
Rv2383c/mbtB	(cc=0.7445)	info on Rv2383c/mbtB
Rv2379c/mbtF	(cc=0.7282)	info on Rv2379c/mbtF
Rv2384/mbtA	(cc=0.6739)	info on Rv2384/mbtA
Rv2381c/mbtD	(cc=0.6427)	info on Rv2381c/mbtD
Rv2564/glnQ	(cc=0.6017)	info on Rv2564/glnQ
Rv2563/-	(cc=0.6004)	info on Rv2563/-
Rv1592c/-	(cc=0.5764)	info on Rv1592c/-
Rv2859c/-	(cc=0.5338)	info on Rv2859c/-
Rv2382c/mbtC	(cc=0.5333)	info on Rv2382c/mbtC

Correlation of Rv2378c/mbtG with Rv2380c/mbtE

Normalized LFCs for Rv2378c/mbtG:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2378c/mbtG	Rv2380c/mbtE
Fe_supp_jason_reseq	1.645	0.863
low_pH_jason_reseq	0.137	0.647
NO_jason_reseq	-0.735	-0.302
B6_jason_reseq	-0.85	-0.421
MHCII_jason_reseq	-0.614	-0.37
Isoniazid02	0.764	0.493
Rifampicin4	-0.712	0.379
Ethambutol3	2.112	-0.073
Meropenem3	-0.587	-0.533
Vancomycin16	0.385	-0.08
Rv2680_day32	-3.19	-1.96
H37Rv_KO_MarP	1.565	1.04
hypoxia_3wks	-2.46	-1.782
hypoxia_6wks	-1.718	-1.222
glycerol	1.862	0.607
cholesterol	0.435	0.371
AJ	-0.983	-0.788
Bibs02	-1.673	-0.94
Bibs02c	-1.707	-0.887
BL6	0.053	-0.768
BL6a	-0.377	-0.839
BXD01	-1.062	-0.8
BXD010	-0.179	-0.659
BXD011	-0.923	-0.54
BXD03	-1.237	-0.695
BXD04	0.559	-0.76
BXD05	0.314	-0.827
BXD06	0.111	-0.566
BXD07	-0.264	-0.851
BXD08	-0.4	-0.817
BXD09	-0.901	-0.863
CAST	0.192	0.0
CCcont	0.399	-0.285
DS01	2.779	2.522
DS02	1.479	0.837
DS04	0.932	0.967
DS0c	0.181	0.0
GP01	-0.903	-0.607
GP02	-0.761	-0.511
GP0c	-1.19	-0.799
NOD	-0.809	0.0
NZO	-0.718	-0.678
PWK	-0.706	-0.516
H37Rv_KO_CtpC	-0.585	-0.2
H37Rv_KO_CtpD	-0.456	-0.333
H37Rv_KO_Rv1272	-0.508	-0.866
H37Rv_KO_SugABC	-0.42	-0.42
H37Rv_KO_MbtN	-0.747	-0.53
Trans05	-1.066	-0.803
macrophage_unactivated	-0.193	0.83
IL1	1.231	0.0
Rapamycin	-0.592	0.0
Tcell	0.375	1.235
GMCSF	-0.694	0.0
IFNab	0.0	0.0
IFNg	0.454	0.0
IFNg_GMCSF1	2.083	0.434
Rv1432_day32	-1.027	-0.18
Rv1565c_day32	1.93	0.0
secA2_input	1.758	1.005
delta_Rv3594	-1.172	-0.635
delta_Rv3717	0.413	-0.522
delta_Rv3811	-1.709	-0.617
delta_Rv0954	0.509	0.0
PonA1	0.945	0.971
EccD1_KO	1.684	1.365
EspI_KO	2.031	0.719
PE35_KO	2.444	2.383
PPE68_KO	3.248	2.086
glycerol2	1.073	0.0
lignocerate	1.464	0.0
oleate	0.373	0.0
phosphatidylcholine	1.073	0.122
acetate	1.127	0.412
glucAc	1.825	0.256
Rv0950ko	1.58	0.0
Rv1096ko	0.347	0.561
Rv3684ko	0.468	0.465
delta_otsA_trehalose	0.492	-1.258