TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2323c/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2633c/-	(cc=0.6728)	info on Rv2633c/-
Rv1956/higA	(cc=0.6395)	info on Rv1956/higA
Rv3295/-	(cc=0.6384)	info on Rv3295/-
Rv0008c/-	(cc=0.6099)	info on Rv0008c/-
Rv0228/-	(cc=0.6041)	info on Rv0228/-
Rv0758/phoR	(cc=0.6016)	info on Rv0758/phoR
Rv2499c/-	(cc=0.5901)	info on Rv2499c/-
Rv1880c/cyp140	(cc=0.58)	info on Rv1880c/cyp140
Rv3353c/-	(cc=0.5777)	info on Rv3353c/-
Rv3059/cyp136	(cc=0.5764)	info on Rv3059/cyp136

Correlation of Rv2323c/- with Rv2633c/-

Normalized LFCs for Rv2323c/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2323c/-	Rv2633c/-
Fe_supp_jason_reseq	-0.036	-0.311
low_pH_jason_reseq	-0.437	-1.37
NO_jason_reseq	0.286	1.982
B6_jason_reseq	0.255	2.097
MHCII_jason_reseq	0.484	2.688
Isoniazid02	0.522	-1.835
Rifampicin4	0.91	0.788
Ethambutol3	0.62	-1.015
Meropenem3	0.73	1.543
Vancomycin16	0.608	0.992
Rv2680_day32	0.87	-1.492
H37Rv_KO_MarP	-0.02	-0.251
hypoxia_3wks	-0.251	-1.635
hypoxia_6wks	-0.065	-0.935
glycerol	-0.489	-3.439
cholesterol	-0.506	-1.698
AJ	-0.482	-1.847
Bibs02	-0.956	-2.015
Bibs02c	-1.263	-1.479
BL6	-0.472	-4.097
BL6a	-1.125	-2.705
BXD01	-0.517	-3.305
BXD010	-0.534	-2.545
BXD011	-0.651	-3.454
BXD03	-1.272	-4.022
BXD04	-0.455	-3.05
BXD05	-0.383	-3.466
BXD06	-0.889	-3.175
BXD07	-0.457	-3.925
BXD08	-0.515	-3.425
BXD09	-0.953	-3.938
CAST	-0.095	-1.121
CCcont	-0.764	-3.226
DS01	-0.198	-2.479
DS02	-0.562	-2.478
DS04	-0.28	-1.739
DS0c	-0.798	-3.309
GP01	-0.054	-2.635
GP02	-0.667	-2.268
GP0c	-0.723	-3.348
NOD	0.285	-0.823
NZO	0.23	-1.331
PWK	-0.122	-1.07
H37Rv_KO_CtpC	0.095	-4.742
H37Rv_KO_CtpD	0.106	-1.586
H37Rv_KO_Rv1272	-0.588	-3.011
H37Rv_KO_SugABC	-1.975	-1.628
H37Rv_KO_MbtN	-0.97	-2.419
Trans05	-1.187	-2.951
macrophage_unactivated	-0.631	-5.293
IL1	-0.831	-4.974
Rapamycin	-1.396	-5.146
Tcell	-1.189	-4.558
GMCSF	0.217	-4.605
IFNab	-1.521	-6.0
IFNg	-1.97	-4.145
IFNg_GMCSF1	-0.946	-4.452
Rv1432_day32	0.296	-1.082
Rv1565c_day32	0.13	-0.234
secA2_input	-0.706	-0.355
delta_Rv3594	-0.309	0.136
delta_Rv3717	0.016	-1.179
delta_Rv3811	-0.324	-0.013
delta_Rv0954	0.377	0.286
PonA1	0.362	0.524
EccD1_KO	-0.401	-0.987
EspI_KO	0.074	-0.337
PE35_KO	-0.356	0.435
PPE68_KO	-0.083	0.701
glycerol2	0.646	2.304
lignocerate	0.738	2.288
oleate	0.451	1.324
phosphatidylcholine	0.422	6.0
acetate	0.472	1.057
glucAc	0.696	0.245
Rv0950ko	0.036	-1.291
Rv1096ko	0.075	-1.846
Rv3684ko	-0.21	-0.55
delta_otsA_trehalose	0.317	-0.497