TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2314c/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv1808/PPE32	(cc=0.532)	info on Rv1808/PPE32
Rv1809/PPE33	(cc=0.4839)	info on Rv1809/PPE33
Rv3287c/rsbW	(cc=0.4453)	info on Rv3287c/rsbW
Rv2240c/-	(cc=0.4417)	info on Rv2240c/-
Rv1220c/-	(cc=0.4211)	info on Rv1220c/-
Rv2463/lipP	(cc=0.4076)	info on Rv2463/lipP
Rv3094c/-	(cc=0.3947)	info on Rv3094c/-
Rv2147c/-	(cc=0.3945)	info on Rv2147c/-
Rv0098/fcoT	(cc=0.3906)	info on Rv0098/fcoT
Rv2887/-	(cc=0.3901)	info on Rv2887/-

Correlation of Rv2314c/- with Rv1808/PPE32

Normalized LFCs for Rv2314c/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv2314c/-	Rv1808/PPE32
Fe_supp_jason_reseq	-0.791	-0.447
low_pH_jason_reseq	-0.838	-1.273
NO_jason_reseq	-0.94	-1.979
B6_jason_reseq	-1.175	-1.203
MHCII_jason_reseq	0.226	-0.609
Isoniazid02	-0.077	0.406
Rifampicin4	0.255	-0.246
Ethambutol3	-0.094	-0.503
Meropenem3	-0.036	-0.171
Vancomycin16	-0.225	0.048
Rv2680_day32	-0.64	-0.217
H37Rv_KO_MarP	-0.47	0.164
hypoxia_3wks	-0.299	0.315
hypoxia_6wks	-0.324	0.269
glycerol	0.285	1.286
cholesterol	0.587	1.71
AJ	-0.338	-0.61
Bibs02	-0.216	0.768
Bibs02c	0.082	0.584
BL6	0.945	0.839
BL6a	0.0	0.824
BXD01	-0.706	-0.11
BXD010	-0.518	0.402
BXD011	0.189	0.343
BXD03	-0.515	0.536
BXD04	-0.214	0.103
BXD05	-0.021	0.714
BXD06	-0.509	0.561
BXD07	0.5	0.373
BXD08	-0.111	0.266
BXD09	-0.635	0.308
CAST	-0.984	-0.956
CCcont	0.36	0.894
DS01	-0.135	1.244
DS02	0.367	0.896
DS04	-0.031	1.204
DS0c	0.322	1.461
GP01	-0.509	0.445
GP02	-0.609	-0.297
GP0c	-0.25	0.413
NOD	-0.83	-0.459
NZO	-0.481	-2.123
PWK	-0.961	-0.53
H37Rv_KO_CtpC	0.53	0.873
H37Rv_KO_CtpD	-0.072	0.862
H37Rv_KO_Rv1272	0.129	0.646
H37Rv_KO_SugABC	0.685	1.25
H37Rv_KO_MbtN	-0.393	0.747
Trans05	-0.397	1.311
macrophage_unactivated	-0.496	0.092
IL1	-0.142	0.733
Rapamycin	0.709	0.991
Tcell	0.15	0.499
GMCSF	0.082	0.618
IFNab	0.342	1.128
IFNg	0.123	0.398
IFNg_GMCSF1	0.622	0.368
Rv1432_day32	-0.89	0.008
Rv1565c_day32	0.753	-0.581
secA2_input	0.152	0.139
delta_Rv3594	-0.233	-0.286
delta_Rv3717	-0.294	-0.132
delta_Rv3811	0.421	-0.14
delta_Rv0954	-0.18	-0.336
PonA1	0.054	-0.766
EccD1_KO	-0.072	0.405
EspI_KO	0.0	0.208
PE35_KO	0.283	0.035
PPE68_KO	0.07	0.368
glycerol2	0.468	1.737
lignocerate	0.347	1.254
oleate	-0.315	-0.23
phosphatidylcholine	-0.034	1.464
acetate	0.841	0.652
glucAc	0.441	0.587
Rv0950ko	-0.778	0.024
Rv1096ko	-0.808	0.081
Rv3684ko	0.344	-0.187
delta_otsA_trehalose	0.169	0.025