TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2070c/cobK:

update plot	correlation	link to info on gene
Rv3829c/-	(cc=0.4855)	info on Rv3829c/-
Rv2977c/thiL	(cc=0.4358)	info on Rv2977c/thiL
Rv1215c/-	(cc=0.419)	info on Rv1215c/-
Rv1785c/cyp143	(cc=0.418)	info on Rv1785c/cyp143
Rv1508A/-	(cc=0.3987)	info on Rv1508A/-
Rv0467/icl1	(cc=0.3931)	info on Rv0467/icl1
Rv0844c/narL	(cc=0.3848)	info on Rv0844c/narL
Rv1627c/-	(cc=0.3742)	info on Rv1627c/-
Rv1932/tpx	(cc=0.3709)	info on Rv1932/tpx
Rv3657c/-	(cc=0.362)	info on Rv3657c/-

Correlation of Rv2070c/cobK with Rv0467/icl1

Normalized LFCs for Rv2070c/cobK:
(description and provenance of datasets)

	Rv2070c/cobK	Rv0467/icl1
Fe_supp_jason_reseq	-1.768	0.182
low_pH_jason_reseq	0.301	-0.211
NO_jason_reseq	0.034	-0.69
B6_jason_reseq	-1.547	-0.292
MHCII_jason_reseq	-1.779	-0.257
Isoniazid02	-0.383	0.201
Rifampicin4	0.065	0.712
Ethambutol3	2.239	0.59
Meropenem3	-0.576	0.165
Vancomycin16	-0.13	0.366
Rv2680_day32	0.443	0.0
H37Rv_KO_MarP	0.594	0.586
hypoxia_3wks	0.319	0.0
hypoxia_6wks	-0.269	0.0
glycerol	0.573	0.554
cholesterol	-0.315	0.0
AJ	0.734	0.0
Bibs02	-1.874	0.0
Bibs02c	-1.426	0.0
BL6	0.972	0.0
BL6a	-0.54	0.0
BXD01	-1.001	0.0
BXD010	-0.722	0.0
BXD011	-0.582	0.0
BXD03	0.573	0.0
BXD04	-0.113	0.0
BXD05	0.93	0.0
BXD06	-0.219	0.0
BXD07	-0.416	0.0
BXD08	-0.09	0.0
BXD09	-0.031	0.0
CAST	0.577	0.0
CCcont	0.064	1.765
DS01	0.592	0.0
DS02	0.268	0.0
DS04	0.122	0.194
DS0c	1.548	0.0
GP01	0.247	0.0
GP02	1.263	0.0
GP0c	0.659	0.0
NOD	0.361	0.0
NZO	0.321	0.0
PWK	-0.479	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	1.398	0.537
H37Rv_KO_Rv1272	0.975	0.0
H37Rv_KO_SugABC	-1.204	0.0
H37Rv_KO_MbtN	-0.119	0.196
Trans05	0.135	0.0
macrophage_unactivated	-0.189	0.0
IL1	-0.558	0.0
Rapamycin	0.264	0.0
Tcell	-0.196	0.0
GMCSF	0.895	0.0
IFNab	1.363	0.0
IFNg	0.649	0.0
IFNg_GMCSF1	-0.591	0.0
Rv1432_day32	-0.591	0.0
Rv1565c_day32	-0.948	0.0
secA2_input	0.678	1.77
delta_Rv3594	-0.136	-0.193
delta_Rv3717	-1.078	-0.159
delta_Rv3811	0.031	-0.391
delta_Rv0954	-0.205	0.65
PonA1	0.416	-0.304
EccD1_KO	0.362	0.0
EspI_KO	0.961	1.859
PE35_KO	1.07	2.917
PPE68_KO	2.109	2.678
glycerol2	-0.604	-1.073
lignocerate	-0.179	-0.933
oleate	-0.611	-1.086
phosphatidylcholine	-0.206	-1.073
acetate	-0.078	0.136
glucAc	0.556	0.451
Rv0950ko	-1.432	-1.182
Rv1096ko	0.296	-2.434
Rv3684ko	-0.812	-1.284
delta_otsA_trehalose	-0.254	0.0