TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1448c/tal:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv1106c/-	(cc=0.4871)	info on Rv1106c/-
Rv0922/-	(cc=0.4567)	info on Rv0922/-
Rv3272/-	(cc=0.4381)	info on Rv3272/-
Rv1391/dfp	(cc=0.4331)	info on Rv1391/dfp
Rv2948c/fadD22	(cc=0.4314)	info on Rv2948c/fadD22
Rv2199c/-	(cc=0.4313)	info on Rv2199c/-
Rv0464c/-	(cc=0.4282)	info on Rv0464c/-
Rv2127/ansP1	(cc=0.4279)	info on Rv2127/ansP1
Rv3253c/-	(cc=0.4139)	info on Rv3253c/-
Rv2685/arsB1	(cc=0.4115)	info on Rv2685/arsB1

Correlation of Rv1448c/tal with Rv1106c/-

Normalized LFCs for Rv1448c/tal:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv1448c/tal	Rv1106c/-
Fe_supp_jason_reseq	-0.957	-0.227
low_pH_jason_reseq	-0.718	0.035
NO_jason_reseq	-2.415	-0.079
B6_jason_reseq	-1.927	-1.55
MHCII_jason_reseq	-1.57	-1.269
Isoniazid02	0.918	-0.677
Rifampicin4	-0.398	-0.42
Ethambutol3	-0.179	-0.714
Meropenem3	-0.056	-0.527
Vancomycin16	-0.255	-0.284
Rv2680_day32	0.082	-1.111
H37Rv_KO_MarP	0.521	-0.217
hypoxia_3wks	-1.994	0.183
hypoxia_6wks	0.474	0.248
glycerol	-1.287	-0.667
cholesterol	-1.507	-1.683
AJ	-0.733	-0.555
Bibs02	0.234	0.348
Bibs02c	0.226	-0.203
BL6	-1.301	0.189
BL6a	-0.092	-0.095
BXD01	-0.83	-0.498
BXD010	-1.184	0.204
BXD011	0.285	-0.335
BXD03	0.303	-0.371
BXD04	-0.553	-0.348
BXD05	-0.649	-0.739
BXD06	-0.062	-0.102
BXD07	-0.619	-0.339
BXD08	-0.848	-1.02
BXD09	-0.956	0.076
CAST	-0.277	-0.524
CCcont	-0.472	0.475
DS01	0.395	-0.565
DS02	-1.049	-0.325
DS04	-1.793	-0.729
DS0c	-1.125	-0.889
GP01	-1.476	-0.345
GP02	-1.099	0.444
GP0c	-1.717	-0.551
NOD	-0.926	-0.844
NZO	-1.956	-0.331
PWK	-0.56	0.158
H37Rv_KO_CtpC	0.56	-0.118
H37Rv_KO_CtpD	-0.807	-0.085
H37Rv_KO_Rv1272	0.815	0.852
H37Rv_KO_SugABC	0.449	0.443
H37Rv_KO_MbtN	-0.844	0.083
Trans05	-0.061	0.388
macrophage_unactivated	0.609	0.23
IL1	-0.125	0.899
Rapamycin	-0.129	0.666
Tcell	1.183	0.479
GMCSF	-0.462	0.333
IFNab	0.583	1.333
IFNg	0.609	0.46
IFNg_GMCSF1	0.826	0.346
Rv1432_day32	-2.339	-1.201
Rv1565c_day32	-1.93	-0.842
secA2_input	-1.565	-0.365
delta_Rv3594	0.788	0.191
delta_Rv3717	0.142	0.388
delta_Rv3811	-0.28	0.25
delta_Rv0954	-0.425	-0.461
PonA1	0.337	-0.141
EccD1_KO	-0.993	0.546
EspI_KO	-0.077	0.53
PE35_KO	0.452	1.073
PPE68_KO	0.086	0.905
glycerol2	0.565	0.405
lignocerate	-0.525	0.381
oleate	-0.208	0.482
phosphatidylcholine	-1.098	0.202
acetate	-0.244	-0.078
glucAc	0.417	0.053
Rv0950ko	0.22	0.302
Rv1096ko	0.691	0.582
Rv3684ko	-0.517	0.793
delta_otsA_trehalose	2.36	0.395