TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1312/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv3283/sseA	(cc=0.5351)	info on Rv3283/sseA
Rv0307c/-	(cc=0.507)	info on Rv0307c/-
Rv1158c/-	(cc=0.5038)	info on Rv1158c/-
Rv2470/glbO	(cc=0.5023)	info on Rv2470/glbO
Rv0411c/glnH	(cc=0.5015)	info on Rv0411c/glnH
Rv1685c/-	(cc=0.4868)	info on Rv1685c/-
Rv1348/irtA	(cc=0.4856)	info on Rv1348/irtA
Rv3005c/-	(cc=0.4849)	info on Rv3005c/-
Rv1432/-	(cc=0.4832)	info on Rv1432/-
Rv1010/ksgA	(cc=0.4763)	info on Rv1010/ksgA

Correlation of Rv1312/- with Rv3283/sseA

Normalized LFCs for Rv1312/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv1312/-	Rv3283/sseA
Fe_supp_jason_reseq	2.455	3.375
low_pH_jason_reseq	-0.156	-0.979
NO_jason_reseq	-1.089	-1.173
B6_jason_reseq	-0.752	-0.649
MHCII_jason_reseq	0.085	0.406
Isoniazid02	-1.214	-1.008
Rifampicin4	-1.933	-2.258
Ethambutol3	-0.49	-1.254
Meropenem3	0.0	-2.709
Vancomycin16	0.355	-2.735
Rv2680_day32	0.0	-2.317
H37Rv_KO_MarP	-1.291	-1.319
hypoxia_3wks	-0.522	-2.181
hypoxia_6wks	-1.094	-1.934
glycerol	-0.856	3.882
cholesterol	0.998	6.0
AJ	-0.541	-1.793
Bibs02	1.922	-0.796
Bibs02c	1.028	0.235
BL6	-0.53	-1.937
BL6a	0.133	-0.725
BXD01	0.171	-1.887
BXD010	0.45	-1.856
BXD011	-0.092	-1.346
BXD03	0.177	-2.094
BXD04	0.083	-1.915
BXD05	-0.436	-1.95
BXD06	0.09	-2.067
BXD07	-0.207	-2.006
BXD08	-0.096	-1.927
BXD09	-0.102	-2.176
CAST	0.155	0.537
CCcont	1.322	0.199
DS01	0.83	2.616
DS02	0.972	0.852
DS04	0.254	1.186
DS0c	0.536	2.855
GP01	-0.32	-1.529
GP02	-0.353	-1.289
GP0c	-0.421	-2.014
NOD	-0.163	0.952
NZO	-0.298	-1.542
PWK	-0.458	-0.59
H37Rv_KO_CtpC	0.213	0.554
H37Rv_KO_CtpD	0.241	-0.229
H37Rv_KO_Rv1272	0.811	-0.956
H37Rv_KO_SugABC	-0.231	-0.926
H37Rv_KO_MbtN	-0.075	-0.797
Trans05	-0.305	-1.893
macrophage_unactivated	-0.246	0.0
IL1	-0.475	-0.955
Rapamycin	-1.679	-1.372
Tcell	0.469	-1.049
GMCSF	-1.751	-1.18
IFNab	-0.75	-1.351
IFNg	0.0	-1.195
IFNg_GMCSF1	-1.386	-1.405
Rv1432_day32	-0.999	-0.999
Rv1565c_day32	0.532	1.848
secA2_input	-0.266	0.881
delta_Rv3594	1.234	-0.569
delta_Rv3717	0.214	-1.432
delta_Rv3811	0.617	-1.487
delta_Rv0954	1.477	3.34
PonA1	1.469	4.717
EccD1_KO	-0.28	1.085
EspI_KO	1.708	0.665
PE35_KO	1.902	4.078
PPE68_KO	2.086	3.072
glycerol2	-0.82	-1.401
lignocerate	-1.762	-1.494
oleate	-0.142	-2.752
phosphatidylcholine	-2.027	-1.162
acetate	-0.637	-0.377
glucAc	-0.938	-1.463
Rv0950ko	0.232	-0.585
Rv1096ko	0.522	-0.148
Rv3684ko	-0.642	0.039
delta_otsA_trehalose	1.129	-0.281