TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1156/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2636/-	(cc=0.6014)	info on Rv2636/-
Rv1181/pks4	(cc=0.5943)	info on Rv1181/pks4
Rv0359/-	(cc=0.5907)	info on Rv0359/-
Rv1736c/narX	(cc=0.5821)	info on Rv1736c/narX
Rv1439c/-	(cc=0.5815)	info on Rv1439c/-
Rv0233/nrdB	(cc=0.5751)	info on Rv0233/nrdB
Rv1180/pks3	(cc=0.5742)	info on Rv1180/pks3
Rv1864c/-	(cc=0.5581)	info on Rv1864c/-
Rv2687c/-	(cc=0.5382)	info on Rv2687c/-
Rv2644c/-	(cc=0.5382)	info on Rv2644c/-

Correlation of Rv1156/- with Rv2636/-

Normalized LFCs for Rv1156/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv1156/-	Rv2636/-
Fe_supp_jason_reseq	1.078	-0.073
low_pH_jason_reseq	0.117	-0.942
NO_jason_reseq	0.911	0.071
B6_jason_reseq	2.32	1.243
MHCII_jason_reseq	2.087	1.783
Isoniazid02	0.451	-0.55
Rifampicin4	0.019	0.162
Ethambutol3	1.796	0.417
Meropenem3	-0.156	-1.06
Vancomycin16	0.17	-0.642
Rv2680_day32	0.014	1.092
H37Rv_KO_MarP	-0.531	0.013
hypoxia_3wks	-0.295	0.056
hypoxia_6wks	-0.05	-0.186
glycerol	-0.053	0.263
cholesterol	-0.077	0.048
AJ	0.666	0.345
Bibs02	0.889	0.177
Bibs02c	0.171	0.358
BL6	-0.456	-0.987
BL6a	-0.201	-0.442
BXD01	-1.023	-1.222
BXD010	-0.631	-0.989
BXD011	-0.029	-1.507
BXD03	-0.81	-1.037
BXD04	-0.038	-1.588
BXD05	0.529	-0.968
BXD06	-0.372	-1.495
BXD07	-0.527	-1.077
BXD08	-0.753	-0.781
BXD09	-0.565	-1.87
CAST	0.717	0.174
CCcont	-1.017	-1.767
DS01	0.527	0.399
DS02	1.152	0.578
DS04	0.028	-0.409
DS0c	0.646	0.083
GP01	0.388	-0.456
GP02	1.962	-0.744
GP0c	-0.588	-0.677
NOD	1.752	0.574
NZO	0.692	0.126
PWK	0.681	-0.057
H37Rv_KO_CtpC	-1.423	-1.77
H37Rv_KO_CtpD	-0.751	-0.581
H37Rv_KO_Rv1272	-0.96	-1.089
H37Rv_KO_SugABC	-0.64	-1.719
H37Rv_KO_MbtN	-0.224	-0.848
Trans05	0.186	-0.088
macrophage_unactivated	-0.657	-0.653
IL1	-0.377	-0.445
Rapamycin	0.064	-0.546
Tcell	-0.596	-0.867
GMCSF	-0.462	-0.446
IFNab	-0.408	-1.155
IFNg	0.366	-0.136
IFNg_GMCSF1	0.22	-0.079
Rv1432_day32	-0.284	-0.16
Rv1565c_day32	0.463	0.062
secA2_input	0.033	1.133
delta_Rv3594	-0.742	-0.601
delta_Rv3717	-0.302	-0.271
delta_Rv3811	-0.897	-0.458
delta_Rv0954	-0.265	0.151
PonA1	-0.918	-0.324
EccD1_KO	0.033	-0.151
EspI_KO	0.168	0.271
PE35_KO	-0.029	-0.079
PPE68_KO	0.429	-0.266
glycerol2	-0.256	0.534
lignocerate	0.42	0.498
oleate	-0.493	0.303
phosphatidylcholine	0.048	0.709
acetate	0.559	0.156
glucAc	0.818	0.155
Rv0950ko	0.136	-0.027
Rv1096ko	1.312	-0.25
Rv3684ko	0.668	-0.662
delta_otsA_trehalose	0.81	0.719