TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0262c/aac:

update plot	correlation	link to info on gene
Rv2970A/-	(cc=0.5404)	info on Rv2970A/-
Rv0997/-	(cc=0.4982)	info on Rv0997/-
Rv2330c/lppP	(cc=0.4974)	info on Rv2330c/lppP
Rv3523/ltp3	(cc=0.461)	info on Rv3523/ltp3
Rv3528c/-	(cc=0.4357)	info on Rv3528c/-
Rv2548/vapC19	(cc=0.4309)	info on Rv2548/vapC19
Rv3741c/-	(cc=0.4295)	info on Rv3741c/-
Rv2737A/-	(cc=0.42)	info on Rv2737A/-
Rv3210c/-	(cc=0.4116)	info on Rv3210c/-
Rv1207/folP2	(cc=0.4107)	info on Rv1207/folP2

Correlation of Rv0262c/aac with Rv3741c/-

Normalized LFCs for Rv0262c/aac:
(description and provenance of datasets)

	Rv0262c/aac	Rv3741c/-
Fe_supp_jason_reseq	0.586	0.341
low_pH_jason_reseq	-0.368	-0.241
NO_jason_reseq	0.391	-0.801
B6_jason_reseq	-0.767	0.089
MHCII_jason_reseq	-0.603	-0.455
Isoniazid02	1.157	0.079
Rifampicin4	1.205	0.092
Ethambutol3	0.879	1.434
Meropenem3	0.041	-0.05
Vancomycin16	0.674	0.196
Rv2680_day32	2.426	0.399
H37Rv_KO_MarP	1.376	0.114
hypoxia_3wks	0.044	-0.439
hypoxia_6wks	0.495	0.301
glycerol	-0.123	-0.407
cholesterol	1.459	0.039
AJ	0.089	-0.113
Bibs02	0.902	-0.592
Bibs02c	-0.041	-0.696
BL6	-0.58	0.025
BL6a	1.53	-0.027
BXD01	0.877	-0.169
BXD010	2.333	-0.475
BXD011	1.184	0.018
BXD03	2.031	-0.228
BXD04	0.396	0.364
BXD05	2.602	0.483
BXD06	1.524	-0.037
BXD07	2.382	0.4
BXD08	1.136	-0.018
BXD09	1.659	0.324
CAST	0.0	-0.445
CCcont	0.623	0.303
DS01	0.578	0.505
DS02	0.083	0.03
DS04	1.307	-0.164
DS0c	-1.796	-0.509
GP01	-1.721	-0.973
GP02	-1.158	-0.626
GP0c	-2.018	-0.942
NOD	0.129	-0.967
NZO	-1.331	-1.263
PWK	0.112	-1.475
H37Rv_KO_CtpC	2.607	0.011
H37Rv_KO_CtpD	0.049	-0.107
H37Rv_KO_Rv1272	-1.592	-1.813
H37Rv_KO_SugABC	0.387	-0.184
H37Rv_KO_MbtN	0.88	0.232
Trans05	0.853	-0.536
macrophage_unactivated	0.085	-0.076
IL1	0.0	0.184
Rapamycin	0.826	0.675
Tcell	-0.427	-0.026
GMCSF	0.977	-0.127
IFNab	1.261	0.478
IFNg	0.679	-0.521
IFNg_GMCSF1	-0.113	0.05
Rv1432_day32	0.299	0.872
Rv1565c_day32	-0.194	-0.362
secA2_input	2.336	0.302
delta_Rv3594	-0.906	-2.14
delta_Rv3717	0.05	-1.552
delta_Rv3811	0.019	-0.669
delta_Rv0954	-0.282	-1.243
PonA1	-0.779	-0.21
EccD1_KO	0.97	1.006
EspI_KO	-0.271	0.707
PE35_KO	-0.403	0.117
PPE68_KO	-0.442	0.339
glycerol2	1.424	0.39
lignocerate	1.46	0.553
oleate	0.529	0.323
phosphatidylcholine	1.13	0.147
acetate	1.493	0.407
glucAc	0.412	0.021
Rv0950ko	-0.145	1.273
Rv1096ko	-0.193	0.492
Rv3684ko	0.052	1.601
delta_otsA_trehalose	-2.049	-0.527