TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0262c/aac:

update plot	correlation	link to info on gene
Rv2970A/-	(cc=0.5404)	info on Rv2970A/-
Rv0997/-	(cc=0.4982)	info on Rv0997/-
Rv2330c/lppP	(cc=0.4974)	info on Rv2330c/lppP
Rv3523/ltp3	(cc=0.461)	info on Rv3523/ltp3
Rv3528c/-	(cc=0.4357)	info on Rv3528c/-
Rv2548/vapC19	(cc=0.4309)	info on Rv2548/vapC19
Rv3741c/-	(cc=0.4295)	info on Rv3741c/-
Rv2737A/-	(cc=0.42)	info on Rv2737A/-
Rv3210c/-	(cc=0.4116)	info on Rv3210c/-
Rv1207/folP2	(cc=0.4107)	info on Rv1207/folP2

Correlation of Rv0262c/aac with Rv3523/ltp3

Normalized LFCs for Rv0262c/aac:
(description and provenance of datasets)

	Rv0262c/aac	Rv3523/ltp3
Fe_supp_jason_reseq	0.586	1.209
low_pH_jason_reseq	-0.368	-0.458
NO_jason_reseq	0.391	0.0
B6_jason_reseq	-0.767	-0.432
MHCII_jason_reseq	-0.603	0.33
Isoniazid02	1.157	1.394
Rifampicin4	1.205	-0.141
Ethambutol3	0.879	1.557
Meropenem3	0.041	0.143
Vancomycin16	0.674	-0.082
Rv2680_day32	2.426	0.566
H37Rv_KO_MarP	1.376	0.353
hypoxia_3wks	0.044	0.227
hypoxia_6wks	0.495	-0.211
glycerol	-0.123	0.208
cholesterol	1.459	0.588
AJ	0.089	-0.242
Bibs02	0.902	0.579
Bibs02c	-0.041	-0.53
BL6	-0.58	0.638
BL6a	1.53	0.36
BXD01	0.877	0.877
BXD010	2.333	0.794
BXD011	1.184	1.443
BXD03	2.031	0.565
BXD04	0.396	0.896
BXD05	2.602	1.023
BXD06	1.524	0.867
BXD07	2.382	0.959
BXD08	1.136	1.21
BXD09	1.659	0.851
CAST	0.0	0.382
CCcont	0.623	1.048
DS01	0.578	-0.599
DS02	0.083	-0.629
DS04	1.307	0.167
DS0c	-1.796	-1.177
GP01	-1.721	-0.333
GP02	-1.158	0.855
GP0c	-2.018	0.367
NOD	0.129	-0.125
NZO	-1.331	-0.269
PWK	0.112	-0.072
H37Rv_KO_CtpC	2.607	0.1
H37Rv_KO_CtpD	0.049	-0.011
H37Rv_KO_Rv1272	-1.592	-1.154
H37Rv_KO_SugABC	0.387	1.007
H37Rv_KO_MbtN	0.88	-0.4
Trans05	0.853	0.36
macrophage_unactivated	0.085	0.133
IL1	0.0	-0.237
Rapamycin	0.826	-0.11
Tcell	-0.427	-0.117
GMCSF	0.977	0.665
IFNab	1.261	-0.175
IFNg	0.679	0.561
IFNg_GMCSF1	-0.113	-0.346
Rv1432_day32	0.299	-0.211
Rv1565c_day32	-0.194	0.117
secA2_input	2.336	-0.106
delta_Rv3594	-0.906	-0.473
delta_Rv3717	0.05	-0.341
delta_Rv3811	0.019	-0.159
delta_Rv0954	-0.282	-0.196
PonA1	-0.779	0.148
EccD1_KO	0.97	-0.924
EspI_KO	-0.271	-0.048
PE35_KO	-0.403	-0.939
PPE68_KO	-0.442	-0.835
glycerol2	1.424	-0.378
lignocerate	1.46	0.172
oleate	0.529	-0.869
phosphatidylcholine	1.13	-0.143
acetate	1.493	-0.55
glucAc	0.412	-0.098
Rv0950ko	-0.145	0.691
Rv1096ko	-0.193	0.404
Rv3684ko	0.052	0.596
delta_otsA_trehalose	-2.049	-2.137